TTD_Target_ID	Target_Name	TTD_Drug_ID	Drug_Name	Drug_Highest_Status	Drug_PubchemID	Molecular_Formula	Molecular_Weight	Canonical_SMILES	Activity	Binder_Type
T11388	Cathepsin K	B06KHG	Arylaminoethyl carbamate, 17	Investigative	23648378	C27H40FN3O4	489.6	C[C@@H](CN1C2=C(CC1(C)C)C=C(C=C2)F)NC(=O)O[C@@H](CC3CCCCC3)C(=O)N4CCOCC4	Ki ~ 100000 nM	Poor binder
T11388	Cathepsin K	B0LA8M	(2S)-2-[[2-(3,5-Dichlorophenyl)acetyl]amino]-3,3-dimethyl-N-[2-[[(E)-3-methylsulfonylprop-2-enyl]amino]-2-oxoethyl]butanamide	Investigative	118720237	C20H27Cl2N3O5S	492.4	CC(C)(C)[C@@H](C(=O)NCC(=O)NC/C=C/S(=O)(=O)C)NC(=O)CC1=CC(=CC(=C1)Cl)Cl	IC50 = 95000 nM	Poor binder
T11388	Cathepsin K	B1ITE4	Benzyl N-[(2S)-5-(diaminomethylideneamino)-1-[[(2S)-1-[[(2S)-1,6-diamino-1-oxohexan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-1-oxopentan-2-yl]carbamate	Investigative	73348857	C29H42N8O5	582.7	C1=CC=C(C=C1)C[C@@H](C(=O)N[C@@H](CCCCN)C(=O)N)NC(=O)[C@H](CCCN=C(N)N)NC(=O)OCC2=CC=CC=C2	Ki = 147000 nM	Poor binder
T11388	Cathepsin K	B1MF2O	Succinamide peptidomimetic, 6	Investigative	11327594	C23H34FN3O3	419.5	C1CCC(CC1)C[C@H](CC(=O)NCCNC2=CC=C(C=C2)F)C(=O)N3CCOCC3	Ki ~ 100000 nM	Poor binder
T11388	Cathepsin K	B1UH0O	Arylaminoethyl amide, 5h	Investigative	23648318	C26H28ClN3O3	466	CC1=CC(=CC=C1)C(=O)N[C@@H](CC2=CC(=CC=C2)Cl)C(=O)NCCNC3=CC=C(C=C3)OC	Ki ~ 100000 nM	Poor binder
T11388	Cathepsin K	B20WVX	Arylaminoethyl amide, 11	Investigative	23648336	C31H37N3O4	515.6	COC1=CC=C(C=C1)NCCNC(=O)[C@H](CC2CCCCC2)NC(=O)C3=CC(=CC=C3)OC4=CC=CC=C4	Ki ~ 100000 nM	Poor binder
T11388	Cathepsin K	B20ZUP	5-((2,3-Dimethylphenoxy)methyl)-3-methyloxazolidin-2-one	Investigative	44426056	C13H17NO3	235.28	CC1=C(C(=CC=C1)OCC2CN(C(=O)O2)C)C	IC50 ~ 100000 nM	Poor binder
T11388	Cathepsin K	B23OLG	Arylaminoethyl amide, 8i	Investigative	23648352	C29H38FN3O4	511.6	COC1=CC=CC(=C1)C(=O)N[C@@H](CCC2CCCCC2)C(=O)N[C@H](CN3CCC4=C3C=CC(=C4)F)CO	Ki ~ 100000 nM	Poor binder
T11388	Cathepsin K	B24QDK	Arylaminoethyl carbamate, 24	Investigative	23648381	C29H44FN3O4	517.7	C[C@@H]1CN(C[C@@H](O1)C)C(=O)[C@H](CC2CCCCC2)OC(=O)N[C@@H](C)CN3CC(C4=C3C=CC(=C4)F)(C)C	Ki ~ 100000 nM	Poor binder
T11388	Cathepsin K	B2AX8H	Dipeptide-derived nitrile, 22	Investigative	11631355	C17H23N3O4	333.4	CC(C)(C)OC(=O)N[C@@H](COCC1=CC=CC=C1)C(=O)NCC#N	Ki ~ 100000 nM	Poor binder
T11388	Cathepsin K	B2VAN9	(3R,4R)-4-(2,3-Dimethylphenoxy)piperidin-3-ol	Investigative	13186896	C13H19NO2	221.29	CC1=C(C(=CC=C1)O[C@@H]2CCNC[C@H]2O)C	IC50 ~ 100000 nM	Poor binder
T11388	Cathepsin K	B2Z3PS	Arylaminoethyl carbamate, 26	Investigative	23648383	C25H38FN3O3	447.6	C[C@@H](CN1CC(C2=C1C=CC(=C2)F)(C)C)NC(=O)O[C@@H](CC3CCCCC3)C(=O)N(C)C	Ki ~ 100000 nM	Poor binder
T11388	Cathepsin K	B30PIS	Succinamide peptidomimetic, 36	Investigative	11376611	C27H31F6N3O4	575.5	CC(C)[C@@H](CNC1=CC=C(C=C1)OC(F)(F)F)NC(=O)[C@@H](CC(=O)N2CCOCC2)C3=CC=C(C=C3)C(F)(F)F	Ki ~ 100000 nM	Poor binder
T11388	Cathepsin K	B31MBQ	Arylaminoethyl amide, 5r	Investigative	23648328	C30H31N3O3	481.6	CC1=CC(=CC=C1)C(=O)N[C@@H](CC2=CC3=CC=CC=C3C=C2)C(=O)NCCNC4=CC=C(C=C4)OC	Ki ~ 100000 nM	Poor binder
T11388	Cathepsin K	B3SJ4D	Arylaminoethyl carbamate, 27	Investigative	23648384	C26H38FN3O3	459.6	C[C@@H](CN1CC(C2=C1C=CC(=C2)F)(C)C)NC(=O)O[C@@H](CC3CCCCC3)C(=O)N4CCC4	Ki ~ 100000 nM	Poor binder
T11388	Cathepsin K	B45BIF	Arylaminoethyl amide, 8g	Investigative	23644741	C36H44FN3O3S	617.8	COC1=CC=CC(=C1)C(=O)N[C@@H](CCC2CCCCC2)C(=O)N[C@H](CN3CCC4=C3C=CC(=C4)F)CSCC5=CC=CC=C5	Ki ~ 100000 nM	Poor binder
T11388	Cathepsin K	B4MAI0	Tert-butyl N-[(3S)-1-[methyl-[(1R)-1-phenylethyl]amino]-1,2-dioxoheptan-3-yl]carbamate	Investigative	44376143	C21H32N2O4	376.5	CCCC[C@@H](C(=O)C(=O)N(C)[C@H](C)C1=CC=CC=C1)NC(=O)OC(C)(C)C	IC50 ~ 100000 nM	Poor binder
T11388	Cathepsin K	B4OK1I	Arylaminoethyl carbamate, 15	Investigative	23644742	C24H28F3N3O5	495.5	C[C@@H](CNC1=CC=C(C=C1)OC(F)(F)F)NC(=O)O[C@@H](CC2=CC=CC=C2)C(=O)N3CCOCC3	Ki ~ 100000 nM	Poor binder
T11388	Cathepsin K	B4VL8N	3-[2-(3,5-Dichlorophenyl)-2-methylpropanoyl]-4-methoxy-N-[2-[[(E)-3-methylsulfonylprop-2-enyl]amino]-2-oxoethyl]benzamide	Investigative	118720236	C24H26Cl2N2O6S	541.4	CC(C)(C1=CC(=CC(=C1)Cl)Cl)C(=O)C2=C(C=CC(=C2)C(=O)NCC(=O)NC/C=C/S(=O)(=O)C)OC	IC50 ~ 100000 nM	Poor binder
T11388	Cathepsin K	B59BKW	Diethylcyanamide	Investigative	12050	C5H10N2	98.15	CCN(CC)C#N	IC50 ~ 100000 nM	Poor binder
T11388	Cathepsin K	B5LTK3	Arylaminoethyl amide, 5t	Investigative	23648330	C32H33N3O3	507.6	CC1=CC(=CC=C1)C(=O)N[C@@H](CC2=CC=C(C=C2)C3=CC=CC=C3)C(=O)NCCNC4=CC=C(C=C4)OC	Ki ~ 100000 nM	Poor binder
T11388	Cathepsin K	B5RKW8	Arylaminoethyl carbamate, 29	Investigative	23648386	C28H42FN3O3	487.6	C[C@@H](CN1CC(C2=C1C=CC(=C2)F)(C)C)NC(=O)O[C@@H](CC3CCCCC3)C(=O)N4CCCCC4	Ki ~ 100000 nM	Poor binder
T11388	Cathepsin K	B5T0WC	N-[2-(Cyanomethylamino)-2-oxoethyl]-3-[2-(3,5-dichlorophenyl)-2-methylpropanoyl]-4-[2-(dimethylamino)ethoxy]benzamide	Investigative	118720233	C25H28Cl2N4O4	519.4	CC(C)(C1=CC(=CC(=C1)Cl)Cl)C(=O)C2=C(C=CC(=C2)C(=O)NCC(=O)NCC#N)OCCN(C)C	IC50 ~ 100000 nM	Poor binder
T11388	Cathepsin K	B5VEA8	Succinamide peptidomimetic, 8	Investigative	11397590	C24H34F3N3O4	485.5	C1CCC(CC1)C[C@H](CC(=O)N2CCOCC2)C(=O)NCCNC3=CC=C(C=C3)OC(F)(F)F	Ki ~ 100000 nM	Poor binder
T11388	Cathepsin K	B5YS4X	N-[(2S)-1-[5-(Furan-2-yl)-1,3,4-oxadiazol-2-yl]-1-oxopentan-2-yl]-2-phenylacetamide	Investigative	44412437	C19H19N3O4	353.4	CCC[C@@H](C(=O)C1=NN=C(O1)C2=CC=CO2)NC(=O)CC3=CC=CC=C3	Ki = 52000 nM	Poor binder
T11388	Cathepsin K	B69UDS	Tert-butyl (2S)-2-[(cyanomethyl)carbamoyl]pyrrolidine-1-carboxylate	Investigative	11514361	C12H19N3O3	253.3	CC(C)(C)OC(=O)N1CCC[C@H]1C(=O)NCC#N	Ki ~ 100000 nM	Poor binder
T11388	Cathepsin K	B6O5BP	Dipeptide-derived nitrile, 27	Investigative	11646851	C16H16F5N3O3	393.31	CC(C)(C)OC(=O)N[C@@H](CC1=C(C(=C(C(=C1F)F)F)F)F)C(=O)NCC#N	Ki ~ 100000 nM	Poor binder
T11388	Cathepsin K	B7PCJ5	Succinamide peptidomimetic, 33	Investigative	11238059	C26H31ClF3N3O4	542	CC(C)[C@@H](CNC1=CC=C(C=C1)OC(F)(F)F)NC(=O)[C@@H](CC(=O)N2CCOCC2)C3=CC=C(C=C3)Cl	Ki ~ 100000 nM	Poor binder
T11388	Cathepsin K	B7PW2U	Arylaminoethyl amide deriv. 32	Investigative	23648405	C23H27F3N4O4	480.5	C1COCCN1C(=O)N[C@@H](CC2=CC=CC=C2)C(=O)NCCNC3=CC=C(C=C3)OC(F)(F)F	Ki ~ 100000 nM	Poor binder
T11388	Cathepsin K	B7X3FI	2,4-Dimethylpentan-3-yl N-[(3S)-1-[[(1R)-1-(1,3,4-oxadiazol-2-yl)ethyl]amino]-1,2-dioxoheptan-3-yl]carbamate	Investigative	44319483	C19H32N4O5	396.5	CCCC[C@@H](C(=O)C(=O)N[C@H](C)C1=NN=CO1)NC(=O)OC(C(C)C)C(C)C	IC50 = 59000 nM	Poor binder
T11388	Cathepsin K	B81UVG	Succinamide peptidomimetic, 7	Investigative	23648362	C23H34FN3O3	419.5	C1CCC(CC1)C[C@@H](CC(=O)NCCNC2=CC=C(C=C2)F)C(=O)N3CCOCC3	Ki ~ 100000 nM	Poor binder
T11388	Cathepsin K	B8CV9U	Dipeptide-derived nitrile, 40	Investigative	11603305	C22H25N3O3	379.5	CC(C)(C)OC(=O)N[C@@H](CC1=CC=CC=C1C2=CC=CC=C2)C(=O)NCC#N	Ki ~ 100000 nM	Poor binder
T11388	Cathepsin K	B8IW1R	Carbamic acid, [2-[(cyanomethyl)amino]-1-methyl-2-oxoethyl]-, 1,1-dimethylethyl ester, (s)-	Investigative	15283376	C10H17N3O3	227.26	C[C@@H](C(=O)NCC#N)NC(=O)OC(C)(C)C	Ki = 136000 nM	Poor binder
T11388	Cathepsin K	B8M4GW	N-[(1-Cyanoazetidin-3-yl)methyl]cyclohexanecarboxamide	Investigative	10198366	C12H19N3O	221.3	C1CCC(CC1)C(=O)NCC2CN(C2)C#N	IC50 ~ 100000 nM	Poor binder
T11388	Cathepsin K	B8T0MK	N-[(1S)-2-[2-(4-Methoxyanilino)ethylamino]-2-oxo-1-pyridin-4-ylethyl]-3-methylbenzamide	Investigative	44404574	C24H26N4O3	418.5	CC1=CC(=CC=C1)C(=O)N[C@@H](C2=CC=NC=C2)C(=O)NCCNC3=CC=C(C=C3)OC	Ki ~ 100000 nM	Poor binder
T11388	Cathepsin K	B9OH0B	Phenylalanine derivative, 37	Investigative	11616689	C17H23N3O3	317.4	CC(C)(C)OC(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N(C)CC#N	Ki ~ 100000 nM	Poor binder
T11388	Cathepsin K	BA1US8	Arylaminoethyl amide, 16	Investigative	23648341	C28H39BrN6O3	587.6	COC1=CC=C(C=C1)NCCNC(=O)[C@H](CC2CCCCC2)NC(=O)C3CCN(CC3)C4=NC=C(C=N4)Br	Ki ~ 100000 nM	Poor binder
T11388	Cathepsin K	BA48JM	Arylaminoethyl amide, 8j	Investigative	23648353	C30H40FN3O4	525.7	COC1=CC=CC(=C1)C(=O)N[C@@H](CCC2CCCCC2)C(=O)N[C@@H](CCO)CN3CCC4=C3C=CC(=C4)F	Ki ~ 100000 nM	Poor binder
T11388	Cathepsin K	BA7P0H	Arylaminoethyl amide, 17	Investigative	23648342	C28H39BrN6O3	587.6	COC1=CC=C(C=C1)NCCNC(=O)[C@H](CC2CCCCC2)NC(=O)C3CCCN(C3)C4=NC=C(C=N4)Br	Ki ~ 100000 nM	Poor binder
T11388	Cathepsin K	BAE10O	(2S)-2-(3,5-Dichlorophenyl)-N-[(3S)-1-[2-[[(E)-3-methylsulfonylprop-2-enyl]amino]-2-oxoethyl]-2-oxopyrrolidin-3-yl]butanamide	Investigative	118720239	C20H25Cl2N3O5S	490.4	CC[C@@H](C1=CC(=CC(=C1)Cl)Cl)C(=O)N[C@H]2CCN(C2=O)CC(=O)NC/C=C/S(=O)(=O)C	IC50 ~ 100000 nM	Poor binder
T11388	Cathepsin K	BB84EI	Succinamide peptidomimetic, 41	Investigative	23648369	C24H25F6N3O4	533.5	C1COCCN1C(=O)C[C@@H](C2=CC=C(C=C2)C(F)(F)F)C(=O)NCCNC3=CC=C(C=C3)OC(F)(F)F	Ki ~ 100000 nM	Poor binder
T11388	Cathepsin K	BBS35I	Azetidine-1-carbonitrile	Investigative	9812750	C4H6N2	82.1	C1CN(C1)C#N	IC50 ~ 100000 nM	Poor binder
T11388	Cathepsin K	BD5WT8	2-[2-Imino-4-(4-methylphenyl)-1,3-thiazol-3-yl]-1-morpholin-4-ylethanone	Investigative	73354067	C16H19N3O2S	317.4	CC1=CC=C(C=C1)C2=CSC(=N)N2CC(=O)N3CCOCC3	Ki = 51240 nM	Poor binder
T11388	Cathepsin K	BE3M2G	Arylaminoethyl amide, 5u	Investigative	23648331	C26H24F5N3O3	521.5	CC1=CC(=CC=C1)C(=O)N[C@@H](CC2=C(C(=C(C(=C2F)F)F)F)F)C(=O)NCCNC3=CC=C(C=C3)OC	Ki ~ 100000 nM	Poor binder
T11388	Cathepsin K	BF0CU8	N-[(1R)-1-[(Benzylsulfonyl)methyl]-2-{[(1S)-1-methyl-2-{[4-(trifluoromethoxy)phenyl]amino}ethyl]amino}-2-oxoethyl]morpholine-4-carboxamide	Investigative	9547980	C25H31F3N4O6S	572.6	C[C@@H](CNC1=CC=C(C=C1)OC(F)(F)F)NC(=O)[C@H](CS(=O)(=O)CC2=CC=CC=C2)NC(=O)N3CCOCC3	Ki ~ 100000 nM	Poor binder
T11388	Cathepsin K	BF8LE3	Arylaminoethyl carbamate, 25	Investigative	23648382	C27H42FN3O4	491.6	C[C@@H](CN1CC(C2=C1C=CC(=C2)F)(C)C)NC(=O)O[C@@H](CC3CCCCC3)C(=O)N(C)CCOC	Ki ~ 100000 nM	Poor binder
T11388	Cathepsin K	BF9C4I	(3S,4R)-4-(2,3-Dimethylphenoxy)piperidin-3-ol	Investigative	6917747	C13H19NO2	221.29	CC1=C(C(=CC=C1)O[C@@H]2CCNC[C@@H]2O)C	IC50 ~ 100000 nM	Poor binder
T11388	Cathepsin K	BF9R4A	Arylaminoethyl amide, 5s	Investigative	23648329	C28H30N4O3	470.6	CC1=CC(=CC=C1)C(=O)N[C@@H](CC2=CC3=CC=CC=C3N2)C(=O)NCCNC4=CC=C(C=C4)OC	Ki ~ 100000 nM	Poor binder
T11388	Cathepsin K	BFW54L	Tert-butyl N-[(S)-[(cyanomethyl)carbamoyl](phenyl)methyl]carbamate	Investigative	11659287	C15H19N3O3	289.33	CC(C)(C)OC(=O)N[C@@H](C1=CC=CC=C1)C(=O)NCC#N	Ki = 90000 nM	Poor binder
T11388	Cathepsin K	BFXT28	N-[2-(Cyanomethylamino)-2-oxoethyl]-3-[2-(3,5-dichlorophenyl)-2-methylpropanoyl]-4-methoxybenzamide	Investigative	118720232	C22H21Cl2N3O4	462.3	CC(C)(C1=CC(=CC(=C1)Cl)Cl)C(=O)C2=C(C=CC(=C2)C(=O)NCC(=O)NCC#N)OC	IC50 ~ 100000 nM	Poor binder
T11388	Cathepsin K	BH9RJ8	Succinamide peptidomimetic, 39	Investigative	11432773	C25H27F6N3O4	547.5	C[C@@H](CNC1=CC=C(C=C1)OC(F)(F)F)NC(=O)[C@@H](CC(=O)N2CCOCC2)C3=CC=C(C=C3)C(F)(F)F	Ki ~ 100000 nM	Poor binder
T11388	Cathepsin K	BHD6A5	Arylaminoethyl amide, 20	Investigative	11649751	C30H34F3N3O4	557.6	COC1=CC=C(C=C1)NCCNC(=O)[C@H](CC2CCCCC2)NC(=O)C3=CC=C(O3)C4=CC(=CC=C4)C(F)(F)F	Ki ~ 65000 nM	Poor binder
T11388	Cathepsin K	BHS06D	(3S)-3-[(2S)-2-[(6-Chloro-1,3-benzoxazol-2-yl)amino]-3-cyclohexylpropanamido]-4-(5-fluoro-2,3-dihydro-1H-indol-1-yl)butanoic acid	Investigative	11376188	C28H32ClFN4O4	543	C1CCC(CC1)C[C@@H](C(=O)N[C@@H](CC(=O)O)CN2CCC3=C2C=CC(=C3)F)NC4=NC5=C(O4)C=C(C=C5)Cl	Ki ~ 100000 nM	Poor binder
T11388	Cathepsin K	BI6C1A	Arylaminoethyl carbamate, 33	Investigative	23648390	C28H43FN4O5S	566.7	C[C@@H](CN1CC(C2=C1C=CC(=C2)F)(C)C)NC(=O)O[C@@H](CC3CCCCC3)C(=O)N4CCN(CC4)S(=O)(=O)C	Ki ~ 100000 nM	Poor binder
T11388	Cathepsin K	BJ1D9C	Phenylalanine derivative, 36	Investigative	10902758	C16H21N3O3	303.36	CC(C)(C)OC(=O)N[C@H](CC1=CC=CC=C1)C(=O)NCC#N	Ki ~ 100000 nM	Poor binder
T11388	Cathepsin K	BJ25BX	Arylaminoethyl amide, 5m	Investigative	23648323	C28H32N4O4	488.6	CC1=CC(=CC=C1)C(=O)N[C@@H](CC2=CC=C(C=C2)NC(=O)C)C(=O)NCCNC3=CC=C(C=C3)OC	Ki ~ 100000 nM	Poor binder
T11388	Cathepsin K	BJ4IA0	Succinamide peptidomimetic, 5	Investigative	23648361	C23H34FN3O3	419.5	C1CCC(CC1)C[C@@H](CC(=O)N2CCOCC2)C(=O)NCCNC3=CC=C(C=C3)F	Ki ~ 100000 nM	Poor binder
T11388	Cathepsin K	BJ9FH1	Arylaminoethyl amide, 5g	Investigative	23648317	C26H28ClN3O3	466	CC1=CC(=CC=C1)C(=O)N[C@@H](CC2=CC=C(C=C2)Cl)C(=O)NCCNC3=CC=C(C=C3)OC	Ki ~ 100000 nM	Poor binder
T11388	Cathepsin K	BJT97U	Ethyl (3S)-3-[(2S)-2-[(6-chloro-1,3-benzoxazol-2-yl)amino]-3-cyclohexylpropanamido]-4-(5-fluoro-2,3-dihydro-1H-indol-1-yl)butanoate	Investigative	11238468	C30H36ClFN4O4	571.1	CCOC(=O)C[C@@H](CN1CCC2=C1C=CC(=C2)F)NC(=O)[C@H](CC3CCCCC3)NC4=NC5=C(O4)C=C(C=C5)Cl	Ki ~ 100000 nM	Poor binder
T11388	Cathepsin K	BK36QG	Arylaminoethyl carbamate, 31	Investigative	23648388	C27H40FN3O5S	537.7	C[C@@H](CN1CC(C2=C1C=CC(=C2)F)(C)C)NC(=O)O[C@@H](CC3CCCCC3)C(=O)N4CCS(=O)(=O)CC4	Ki ~ 100000 nM	Poor binder
T11388	Cathepsin K	BK9V8A	Arylaminoethyl amide, 8c	Investigative	11226457	C32H44FN3O3	537.7	CC(C)C[C@@H](CN1CCC2=C1C=CC(=C2)F)NC(=O)[C@H](CCC3CCCCC3)NC(=O)C4=CC(=CC=C4)OC	Ki ~ 100000 nM	Poor binder
T11388	Cathepsin K	BKU07J	Heterocyclic arylaminoethyl amide, 12e	Investigative	11353015	C29H36ClFN4O2	527.1	C[C@@H](CN1C2=C(CC1(C)C)C=C(C=C2)F)NC(=O)[C@H](CC3CCCCC3)NC4=NC5=C(O4)C(=CC=C5)Cl	Ki ~ 100000 nM	Poor binder
T11388	Cathepsin K	BKYI81	Arylaminoethyl carbamate, 18	Investigative	16046125	C27H40FN3O4	489.6	C[C@@H](CN1CC(C2=C1C=CC(=C2)F)(C)C)NC(=O)O[C@@H](CC3CCCCC3)C(=O)N4CCOCC4	Ki ~ 100000 nM	Poor binder
T11388	Cathepsin K	BMY40E	Arylaminoethyl amide, 5d	Investigative	23648314	C27H37N3O3	451.6	CC1=CC(=CC=C1)C(=O)N[C@@H](CCC2CCCCC2)C(=O)NCCNC3=CC=C(C=C3)OC	Ki ~ 100000 nM	Poor binder
T11388	Cathepsin K	BNET60	Succinamide peptidomimetic, 38	Investigative	23648368	C27H31F6N3O4	575.5	CC(C)[C@@H](CNC1=CC=C(C=C1)OC(F)(F)F)NC(=O)[C@@H](CC(=O)N2CCOCC2)C3=CC=CC=C3C(F)(F)F	Ki ~ 100000 nM	Poor binder
T11388	Cathepsin K	BO1ZP0	Succinamide peptidomimetic, 40	Investigative	11410560	C27H29F6N3O4	573.5	C1CC1[C@@H](CNC2=CC=C(C=C2)OC(F)(F)F)NC(=O)[C@@H](CC(=O)N3CCOCC3)C4=CC=C(C=C4)C(F)(F)F	Ki ~ 100000 nM	Poor binder
T11388	Cathepsin K	BOCP70	(2S)-2-[[(2S)-2-(3,5-Dichlorophenyl)-2-(ethylamino)acetyl]amino]-3,3-dimethyl-N-[2-[[(E)-3-methylsulfonylprop-2-enyl]amino]-2-oxoethyl]butanamide	Investigative	118720238	C22H32Cl2N4O5S	535.5	CCN[C@@H](C1=CC(=CC(=C1)Cl)Cl)C(=O)N[C@H](C(=O)NCC(=O)NC/C=C/S(=O)(=O)C)C(C)(C)C	IC50 = 73000 nM	Poor binder
T11388	Cathepsin K	BOI7E8	Arylaminoethyl amide, 5k	Investigative	23648321	C27H28F3N3O3	499.5	CC1=CC(=CC=C1)C(=O)N[C@@H](CC2=CC=C(C=C2)C(F)(F)F)C(=O)NCCNC3=CC=C(C=C3)OC	Ki ~ 100000 nM	Poor binder
T11388	Cathepsin K	BOX7D8	(S)-Tert-Butyl (3,3-dimethyl-1-oxobutan-2-yl)carbamate	Investigative	10059139	C11H21NO3	215.29	CC(C)(C)[C@@H](C=O)NC(=O)OC(C)(C)C	IC50 = 52000 nM	Poor binder
T11388	Cathepsin K	BP36GN	Arylaminoethyl amide, 5q	Investigative	23648327	C23H26N4O3S	438.5	CC1=CC(=CC=C1)C(=O)N[C@@H](CC2=CN=CS2)C(=O)NCCNC3=CC=C(C=C3)OC	Ki ~ 100000 nM	Poor binder
T11388	Cathepsin K	BQ3K5V	Succinamide peptidomimetic, 37	Investigative	23648367	C27H31F6N3O4	575.5	CC(C)[C@@H](CNC1=CC=C(C=C1)OC(F)(F)F)NC(=O)[C@@H](CC(=O)N2CCOCC2)C3=CC(=CC=C3)C(F)(F)F	Ki ~ 100000 nM	Poor binder
T11388	Cathepsin K	BQ3Z6S	Arylaminoethyl amide, 8a	Investigative	11784942	C28H36FN3O3	481.6	COC1=CC=CC(=C1)C(=O)N[C@@H](CCC2CCCCC2)C(=O)NCCN3CCC4=C3C=CC(=C4)F	Ki ~ 100000 nM	Poor binder
T11388	Cathepsin K	BQN5E0	Dipeptide-derived nitrile, 34	Investigative	11523212	C20H23N3O3	353.4	CC(C)(C)OC(=O)N[C@@H](CC1=CC2=CC=CC=C2C=C1)C(=O)NCC#N	Ki = 83000 nM	Poor binder
T11388	Cathepsin K	BQV2N6	Succinamide peptidomimetic, 24	Investigative	23648364	C24H36F3N3O4	487.6	C[C@@H](CNC1=CC=C(C=C1)OC(F)(F)F)NC(=O)[C@H](CCC(C)(C)C)CC(=O)N2CCOCC2	Ki ~ 100000 nM	Poor binder
T11388	Cathepsin K	BR4W8P	Arylaminoethyl carbamate, 32	Investigative	23648389	C29H43FN4O4	530.7	C[C@@H](CN1CC(C2=C1C=CC(=C2)F)(C)C)NC(=O)O[C@@H](CC3CCCCC3)C(=O)N4CCN(CC4)C(=O)C	Ki ~ 100000 nM	Poor binder
T11388	Cathepsin K	BT5V2L	Phenylalanine derivative, 48	Investigative	11652420	C15H20N4O3	304.34	CC(C)(C)OC(=O)NN(CC1=CC=CC=C1)C(=O)NCC#N	Ki ~ 100000 nM	Poor binder
T11388	Cathepsin K	BTPX91	Arylaminoethyl amide, 8o	Investigative	23648357	C35H42FN3O4	587.7	COC1=CC=CC(=C1)C(=O)N[C@@H](CCC2CCCCC2)C(=O)N[C@@H](CC3=CC=C(C=C3)O)CN4CCC5=C4C=CC(=C5)F	Ki ~ 100000 nM	Poor binder
T11388	Cathepsin K	BUX23V	Arylaminoethyl amide, 5j	Investigative	23648320	C27H31N3O3	445.6	CC1=CC=C(C=C1)C[C@@H](C(=O)NCCNC2=CC=C(C=C2)OC)NC(=O)C3=CC=CC(=C3)C	Ki ~ 65000 nM	Poor binder
T11388	Cathepsin K	BUZ56D	Arylaminoethyl amide, 10	Investigative	23648335	C31H36ClN3O3	534.1	COC1=CC=C(C=C1)NCCNC(=O)[C@H](CC2CCCCC2)NC(=O)C3=CC=C(C=C3)C4=CC(=CC=C4)Cl	Ki ~ 100000 nM	Poor binder
T11388	Cathepsin K	BVI9X2	Tert-butyl (3S)-3-[(2S)-2-[(6-chloro-1,3-benzoxazol-2-yl)amino]-3-cyclohexylpropanamido]-4-(5-fluoro-2,3-dihydro-1H-indol-1-yl)butanoate	Investigative	11456165	C32H40ClFN4O4	599.1	CC(C)(C)OC(=O)C[C@@H](CN1CCC2=C1C=CC(=C2)F)NC(=O)[C@H](CC3CCCCC3)NC4=NC5=C(O4)C=C(C=C5)Cl	Ki ~ 100000 nM	Poor binder
T11388	Cathepsin K	BW0Z3C	(3S)-N-Tert-Butyl-2-oxo-3-(tert-butoxycarbonylamino)heptanamide	Investigative	44375719	C16H30N2O4	314.42	CCCC[C@@H](C(=O)C(=O)NC(C)(C)C)NC(=O)OC(C)(C)C	IC50 ~ 100000 nM	Poor binder
T11388	Cathepsin K	BX24RV	Arylaminoethyl carbamate, 28	Investigative	23648385	C27H40FN3O3	473.6	C[C@@H](CN1CC(C2=C1C=CC(=C2)F)(C)C)NC(=O)O[C@@H](CC3CCCCC3)C(=O)N4CCCC4	Ki ~ 100000 nM	Poor binder
T11388	Cathepsin K	BX37CB	Dipeptide-derived nitrile, 33	Investigative	11710096	C20H23N3O3	353.4	CC(C)(C)OC(=O)N[C@@H](CC1=CC=CC2=CC=CC=C21)C(=O)NCC#N	Ki = 66000 nM	Poor binder
T11388	Cathepsin K	BY0G8F	Arylaminoethyl amide, 8e	Investigative	23648350	C35H42FN3O3	571.7	COC1=CC=CC(=C1)C(=O)N[C@@H](CCC2CCCCC2)C(=O)N[C@@H](CC3=CC=CC=C3)CN4CCC5=C4C=CC(=C5)F	Ki ~ 100000 nM	Poor binder
T11388	Cathepsin K	BY43HB	Heterocyclic arylaminoethyl amide, 12g	Investigative	23648360	C27H30ClFN4O3	513	C[C@@H](CN1C(=O)CC2=C1C=CC(=C2)F)NC(=O)[C@H](CC3CCCCC3)NC4=NC5=C(O4)C(=CC=C5)Cl	Ki ~ 100000 nM	Poor binder
T11388	Cathepsin K	BY9GH7	Arylaminoethyl amide, 8d	Investigative	11295906	C34H40FN3O3	557.7	COC1=CC=CC(=C1)C(=O)N[C@@H](CCC2CCCCC2)C(=O)N[C@H](CN3CCC4=C3C=CC(=C4)F)C5=CC=CC=C5	Ki ~ 100000 nM	Poor binder
T11388	Cathepsin K	BYQL19	N-[(1S)-2-[2-(4-Methoxyanilino)ethylamino]-2-oxo-1-pyridin-3-ylethyl]-3-methylbenzamide	Investigative	44404573	C24H26N4O3	418.5	CC1=CC(=CC=C1)C(=O)N[C@@H](C2=CN=CC=C2)C(=O)NCCNC3=CC=C(C=C3)OC	Ki ~ 100000 nM	Poor binder
T11388	Cathepsin K	BZ2Q1A	Arylaminoethyl carbamate, 30	Investigative	23648387	C27H40FN3O3S	505.7	C[C@@H](CN1CC(C2=C1C=CC(=C2)F)(C)C)NC(=O)O[C@@H](CC3CCCCC3)C(=O)N4CCSCC4	Ki ~ 100000 nM	Poor binder
T11388	Cathepsin K	BZD9Q8	Arylaminoethyl amide, 5l	Investigative	23648322	C27H31N3O4	461.6	CC1=CC(=CC=C1)C(=O)N[C@@H](CC2=CC=C(C=C2)OC)C(=O)NCCNC3=CC=C(C=C3)OC	Ki ~ 100000 nM	Poor binder
T11388	Cathepsin K	D07SOQ	N-(2-naphthylsulfonyl)-glycyl-glycine-nitrile	Investigative	11652399	C14H13N3O3S	303.34	C1=CC=C2C=C(C=CC2=C1)S(=O)(=O)NCC(=O)NCC#N	Ki ~ 100000 nM	Poor binder