TTD_Target_ID	Target_Name	TTD_Drug_ID	Drug_Name	Drug_Highest_Status	Drug_PubchemID	Molecular_Formula	Molecular_Weight	Canonical_SMILES	Activity	Binder_Type
T13726	Retinoic acid receptor RXR-alpha	D0Z5IU	Sulindac	Approved	1548887	C20H17FO3S	356.4	CC\\1=C(C2=C(/C1=C\\C3=CC=C(C=C3)S(=O)C)C=CC(=C2)F)CC(=O)O	IC50 = 82900 nM	Poor binder
T13726	Retinoic acid receptor RXR-alpha	B07JKC	2-[(3Z)-2,6-Dimethyl-3-[(4-propan-2-ylphenyl)methylidene]inden-1-yl]acetic acid	Investigative	54588851	C23H24O2	332.4	CC1=CC2=C(C=C1)/C(=C\\C3=CC=C(C=C3)C(C)C)/C(=C2CC(=O)O)C	IC50 ~ 100000 nM	Poor binder
T13726	Retinoic acid receptor RXR-alpha	B0DM4T	2-[(3Z)-3-[[4-(Dimethylamino)phenyl]methylidene]-6-fluoro-2-methylinden-1-yl]acetic acid	Investigative	10286680	C21H20FNO2	337.4	CC\\1=C(C2=C(/C1=C\\C3=CC=C(C=C3)N(C)C)C=CC(=C2)F)CC(=O)O	IC50 ~ 100000 nM	Poor binder
T13726	Retinoic acid receptor RXR-alpha	B0GDZ8	4-[5,7,7,10,10-Pentamethyl-2-(methylamino)-8,9-dihydronaphtho[2,3-b][1,5]benzodiazepin-12-yl]benzoic acid	Investigative	44433353	C30H33N3O2	467.6	CC1(CCC(C2=C1C=C3C(=C2)N(C4=C(C=C(C=C4)NC)N=C3C5=CC=C(C=C5)C(=O)O)C)(C)C)C	IC50 ~ 100000 nM	Poor binder
T13726	Retinoic acid receptor RXR-alpha	B0ZD8Y	2-[(3Z)-3-[(3-Cyanophenyl)methylidene]-6-fluoro-2-methylinden-1-yl]acetic acid	Investigative	54588816	C20H14FNO2	319.3	CC\\1=C(C2=C(/C1=C\\C3=CC(=CC=C3)C#N)C=CC(=C2)F)CC(=O)O	IC50 ~ 100000 nM	Poor binder
T13726	Retinoic acid receptor RXR-alpha	B1RL4V	2-[(3Z)-6-Fluoro-2-methyl-3-[(4-pyridin-2-ylphenyl)methylidene]inden-1-yl]acetic acid	Investigative	54588856	C24H18FNO2	371.4	CC\\1=C(C2=C(/C1=C\\C3=CC=C(C=C3)C4=CC=CC=N4)C=CC(=C2)F)CC(=O)O	IC50 ~ 100000 nM	Poor binder
T13726	Retinoic acid receptor RXR-alpha	B3L4EI	2-[(3Z)-6-Fluoro-2-methyl-3-[(4-propan-2-ylphenyl)methylidene]inden-1-yl]acetamide	Investigative	54589363	C22H22FNO	335.4	CC\\1=C(C2=C(/C1=C\\C3=CC=C(C=C3)C(C)C)C=CC(=C2)F)CC(=O)N	IC50 ~ 100000 nM	Poor binder
T13726	Retinoic acid receptor RXR-alpha	B59JQP	4-[2-(Butylamino)-5,7,7,10,10-pentamethyl-8,9-dihydronaphtho[2,3-b][1,5]benzodiazepin-12-yl]benzoic acid	Investigative	44433354	C33H39N3O2	509.7	CCCCNC1=CC2=C(C=C1)N(C3=CC4=C(C=C3C(=N2)C5=CC=C(C=C5)C(=O)O)C(CCC4(C)C)(C)C)C	IC50 ~ 100000 nM	Poor binder
T13726	Retinoic acid receptor RXR-alpha	B5OHR7	2-[3-[(4-Methylphenyl)carbamoyl]-4-piperidin-1-ylphenyl]indazole-6-carboxylic acid	Investigative	102004339	C27H26N4O3	454.5	CC1=CC=C(C=C1)NC(=O)C2=C(C=CC(=C2)N3C=C4C=CC(=CC4=N3)C(=O)O)N5CCCCC5	EC50 ~ 100000 nM	Poor binder
T13726	Retinoic acid receptor RXR-alpha	B5RVP2	4-[(Z)-N-Ethoxy-C-(3,5,5,8,8-pentamethyl-6,7-dihydronaphthalen-2-yl)carbonimidoyl]benzoic acid	Investigative	10644298	C25H31NO3	393.5	CCO/N=C(/C1=CC=C(C=C1)C(=O)O)\\C2=CC3=C(C=C2C)C(CCC3(C)C)(C)C	EC50 ~ 100000 nM	Poor binder
T13726	Retinoic acid receptor RXR-alpha	B87SPI	2-[(3Z)-6-Chloro-2-methyl-3-[(4-propan-2-ylphenyl)methylidene]inden-1-yl]acetic acid	Investigative	54588894	C22H21ClO2	352.9	CC\\1=C(C2=C(/C1=C\\C3=CC=C(C=C3)C(C)C)C=CC(=C2)Cl)CC(=O)O	IC50 ~ 100000 nM	Poor binder
T13726	Retinoic acid receptor RXR-alpha	B8JK1P	2-[(3Z)-6-Ethyl-2-methyl-3-[(4-propan-2-ylphenyl)methylidene]inden-1-yl]acetic acid	Investigative	54588891	C24H26O2	346.5	CCC1=CC2=C(C=C1)/C(=C\\C3=CC=C(C=C3)C(C)C)/C(=C2CC(=O)O)C	IC50 ~ 100000 nM	Poor binder
T13726	Retinoic acid receptor RXR-alpha	BC10WA	2-[(3Z)-3-[(4-Tert-butylphenyl)methylidene]-6-fluoro-2-methylinden-1-yl]acetic acid	Investigative	54588776	C23H23FO2	350.4	CC\\1=C(C2=C(/C1=C\\C3=CC=C(C=C3)C(C)(C)C)C=CC(=C2)F)CC(=O)O	IC50 ~ 100000 nM	Poor binder
T13726	Retinoic acid receptor RXR-alpha	BK6M3I	2-[(3Z)-3-[(4-Cyanophenyl)methylidene]-6-fluoro-2-methylinden-1-yl]acetic acid	Investigative	54588815	C20H14FNO2	319.3	CC\\1=C(C2=C(/C1=C\\C3=CC=C(C=C3)C#N)C=CC(=C2)F)CC(=O)O	IC50 ~ 100000 nM	Poor binder
T13726	Retinoic acid receptor RXR-alpha	BR65OL	4-[(Z)-N-[(2-Methylpropan-2-yl)oxy]-C-(3,5,5,8,8-pentamethyl-6,7-dihydronaphthalen-2-yl)carbonimidoyl]benzoic acid	Investigative	10645862	C27H35NO3	421.6	CC1=CC2=C(C=C1/C(=N\\OC(C)(C)C)/C3=CC=C(C=C3)C(=O)O)C(CCC2(C)C)(C)C	EC50 ~ 100000 nM	Poor binder
T13726	Retinoic acid receptor RXR-alpha	BS3U7Q	2-[(3Z)-3-[(4-Ethoxyphenyl)methylidene]-6-fluoro-2-methylinden-1-yl]acetic acid	Investigative	54588812	C21H19FO3	338.4	CCOC1=CC=C(C=C1)/C=C\\2/C(=C(C3=C2C=CC(=C3)F)CC(=O)O)C	IC50 ~ 100000 nM	Poor binder
T13726	Retinoic acid receptor RXR-alpha	BSG3K7	2-[(3Z)-2-Methyl-3-[(4-propan-2-ylphenyl)methylidene]inden-1-yl]acetic acid	Investigative	54588850	C22H22O2	318.4	CC\\1=C(C2=CC=CC=C2/C1=C\\C3=CC=C(C=C3)C(C)C)CC(=O)O	IC50 ~ 100000 nM	Poor binder
T13726	Retinoic acid receptor RXR-alpha	BSMY03	4-[[(E)-Tert-Butoxyimino]-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydro-naphthalen-2-yl)-methyl]-benzoic acid	Investigative	10598286	C27H35NO3	421.6	CC1=CC2=C(C=C1/C(=N/OC(C)(C)C)/C3=CC=C(C=C3)C(=O)O)C(CCC2(C)C)(C)C	EC50 ~ 100000 nM	Poor binder
T13726	Retinoic acid receptor RXR-alpha	BTO28X	1-[(Z)-3-Methoxybenzylidene]-2-methyl-5-fluoro-1H-indene-3-acetic acid	Investigative	44375294	C20H17FO3	324.3	CC\\1=C(C2=C(/C1=C\\C3=CC(=CC=C3)OC)C=CC(=C2)F)CC(=O)O	IC50 ~ 100000 nM	Poor binder
T13726	Retinoic acid receptor RXR-alpha	BU1Q6D	2-[(3Z)-6-Methoxy-2-methyl-3-[(4-propan-2-ylphenyl)methylidene]inden-1-yl]acetic acid	Investigative	54588852	C23H24O3	348.4	CC\\1=C(C2=C(/C1=C\\C3=CC=C(C=C3)C(C)C)C=CC(=C2)OC)CC(=O)O	IC50 ~ 100000 nM	Poor binder
T13726	Retinoic acid receptor RXR-alpha	BV85PO	4-[2-(Benzylamino)-5,7,7,10,10-pentamethyl-8,9-dihydronaphtho[2,3-b][1,5]benzodiazepin-12-yl]benzoic acid	Investigative	44433355	C36H37N3O2	543.7	CC1(CCC(C2=C1C=C3C(=C2)N(C4=C(C=C(C=C4)NCC5=CC=CC=C5)N=C3C6=CC=C(C=C6)C(=O)O)C)(C)C)C	IC50 ~ 100000 nM	Poor binder
T13726	Retinoic acid receptor RXR-alpha	BWN8Z9	1-[(Z)-4-Methoxybenzylidene]-2-methyl-5-fluoro-1H-indene-3-acetic acid	Investigative	9858424	C20H17FO3	324.3	CC\\1=C(C2=C(/C1=C\\C3=CC=C(C=C3)OC)C=CC(=C2)F)CC(=O)O	IC50 ~ 100000 nM	Poor binder
T13726	Retinoic acid receptor RXR-alpha	BWU5L1	3-[(3Z)-6-Fluoro-2-methyl-3-[(4-propan-2-ylphenyl)methylidene]inden-1-yl]propanenitrile	Investigative	54589361	C23H22FN	331.4	CC\\1=C(C2=C(/C1=C\\C3=CC=C(C=C3)C(C)C)C=CC(=C2)F)CCC#N	IC50 ~ 100000 nM	Poor binder
T13726	Retinoic acid receptor RXR-alpha	BX3KC2	2-[(3E)-6-Fluoro-2-methyl-3-[(4-propan-2-ylphenyl)methylidene]inden-1-yl]acetamide	Investigative	54588811	C22H22FNO	335.4	CC\\1=C(C2=C(/C1=C/C3=CC=C(C=C3)C(C)C)C=CC(=C2)F)CC(=O)N	IC50 ~ 100000 nM	Poor binder
T13726	Retinoic acid receptor RXR-alpha	BXK05L	2-[(3Z)-3-[(4-Acetamidophenyl)methylidene]-6-fluoro-2-methylinden-1-yl]acetic acid	Investigative	54588890	C21H18FNO3	351.4	CC\\1=C(C2=C(/C1=C\\C3=CC=C(C=C3)NC(=O)C)C=CC(=C2)F)CC(=O)O	IC50 ~ 100000 nM	Poor binder
T13726	Retinoic acid receptor RXR-alpha	BYGP36	2-[(3Z)-2-Methyl-6-propan-2-yl-3-[(4-propan-2-ylphenyl)methylidene]inden-1-yl]acetic acid	Investigative	54588893	C25H28O2	360.5	CC\\1=C(C2=C(/C1=C\\C3=CC=C(C=C3)C(C)C)C=CC(=C2)C(C)C)CC(=O)O	IC50 ~ 100000 nM	Poor binder