TTD_Target_ID	Target_Name	TTD_Drug_ID	Drug_Name	Drug_Highest_Status	Drug_PubchemID	Molecular_Formula	Molecular_Weight	Canonical_SMILES	Activity	Binder_Type
T14597	Erbb2 tyrosine kinase receptor	D01PZD	Romiplostim	Approved	5329098	C15H14N2O	238.28	CC1=CC(=C(N1)/C=C\\2/C3=CC=CC=C3NC2=O)C	IC50 ~ 100000 nM	Poor binder
T14597	Erbb2 tyrosine kinase receptor	D02TUL	PF-06651600	Phase 2	118115473	C15H19N5O	285.34	C[C@H]1CC[C@H](CN1C(=O)C=C)NC2=NC=NC3=C2C=CN3	IC50 ~ 50000 nM	Poor binder
T14597	Erbb2 tyrosine kinase receptor	B03LKR	2-(1H-Benzimidazol-2-ylmethyl)-5-(2,3-dimethoxyphenyl)-1,3,4-oxadiazole	Investigative	137633149	C18H16N4O3	336.3	COC1=CC=CC(=C1OC)C2=NN=C(O2)CC3=NC4=CC=CC=C4N3	IC50 ~ 100000 nM	Poor binder
T14597	Erbb2 tyrosine kinase receptor	B06VHA	1-(4-Fluorobenzyl)-1-(2-hydroxy-3,5-dimethylbenzyl)-3-phenylurea	Investigative	46229380	C23H23FN2O2	378.4	CC1=CC(=C(C(=C1)CN(CC2=CC=C(C=C2)F)C(=O)NC3=CC=CC=C3)O)C	IC50 ~ 50000 nM	Poor binder
T14597	Erbb2 tyrosine kinase receptor	B0AF9K	1-Butyl-1-(5-chloro-2-hydroxybenzyl)-3-phenylurea	Investigative	46229459	C18H21ClN2O2	332.8	CCCCN(CC1=C(C(=CC=C1)Cl)O)C(=O)NC2=CC=CC=C2	IC50 ~ 50000 nM	Poor binder
T14597	Erbb2 tyrosine kinase receptor	B0D2BC	N-(3-Chloro-4-(3-fluorobenzyloxy)phenyl)-6-phenoxypyrimidin-4-amine	Investigative	53321087	C23H17ClFN3O2	421.8	C1=CC=C(C=C1)OC2=NC=NC(=C2)NC3=CC(=C(C=C3)OCC4=CC(=CC=C4)F)Cl	IC50 ~ 100000 nM	Poor binder
T14597	Erbb2 tyrosine kinase receptor	B0IQ9N	3-[(Z)-(4-Bromo-2-thienyl)methylidene]-1H-indol-2-one	Investigative	6036100	C13H8BrNOS	306.18	C1=CC=C2C(=C1)/C(=C/C3=CC(=CS3)Br)/C(=O)N2	IC50 ~ 100000 nM	Poor binder
T14597	Erbb2 tyrosine kinase receptor	B0SHG1	(Z)-1-Methyl-3-(4-dimethylaminobenzylidene)indoline-2-one	Investigative	5293755	C18H18N2O	278.3	CN1C2=CC=CC=C2/C(=C/C3=CC=C(C=C3)N(C)C)/C1=O	IC50 ~ 100000 nM	Poor binder
T14597	Erbb2 tyrosine kinase receptor	B13UPZ	2-(6-Amino-9H-purine-9-yl)-1-(1H-indole-3-yl)ethanone	Investigative	42603880	C15H12N6O	292.3	C1=CC=C2C(=C1)C(=CN2)C(=O)CN3C=NC4=C(N=CN=C43)N	IC50 = 95000 nM	Poor binder
T14597	Erbb2 tyrosine kinase receptor	B17HJV	2-(5-Isoquinolin-4-yl-1H-pyrazolo[3,4-b]pyridin-3-yl)-1H-benzoimidazole-4-carboxylic acid	Investigative	136118033	C23H14N6O2	406.4	C1=CC=C2C(=C1)C=NC=C2C3=CC4=C(NN=C4N=C3)C5=NC6=C(C=CC=C6N5)C(=O)O	IC50 ~ 100000 nM	Poor binder
T14597	Erbb2 tyrosine kinase receptor	B1IR3H	4-[4-(5-Bromo-2-oxo-1,2-dihydro-indol-3-ylidenemethyl)-phenyl]-piperazine-1-carbaldehyde	Investigative	44321734	C20H18BrN3O2	412.3	C1CN(CCN1C=O)C2=CC=C(C=C2)/C=C\\3/C4=C(C=CC(=C4)Br)NC3=O	IC50 ~ 50000 nM	Poor binder
T14597	Erbb2 tyrosine kinase receptor	B1QHW6	Methyl 5-(2-(3-(6-methoxy-1H-benzo[d]imidazol-2-yl)-1H-pyrazol-4-yl)vinyl)nicotinate	Investigative	135620676	C20H17N5O3	375.4	COC1=CC2=C(C=C1)N=C(N2)C3=C(C=NN3)/C=C/C4=CC(=CN=C4)C(=O)OC	IC50 ~ 100000 nM	Poor binder
T14597	Erbb2 tyrosine kinase receptor	B25WIS	2-[3-Methyl-4-hydroxy-5-methoxybenzylidene]propanedinitrile	Investigative	44345337	C12H10N2O2	214.22	CC1=CC(=CC(=C1O)OC)C=C(C#N)C#N	IC50 = 112201.85 nM	Poor binder
T14597	Erbb2 tyrosine kinase receptor	B26WGE	4-(3-(4-(Isopropoxymethyl)-1H-benzo[d]imidazol-2-yl)-1H-pyrazolo[3,4-b]pyridin-5-yl)isoquinoline	Investigative	135497877	C26H22N6O	434.5	CC(C)OCC1=C2C(=CC=C1)NC(=N2)C3=C4C=C(C=NC4=NN3)C5=CN=CC6=CC=CC=C65	IC50 ~ 100000 nM	Poor binder
T14597	Erbb2 tyrosine kinase receptor	B2D0IS	N-(3-Chloro-4-(3-fluorobenzyloxy)phenyl)-6-(pyridin-3-yl)pyrimidin-4-amine	Investigative	53324027	C22H16ClFN4O	406.8	C1=CC(=CC(=C1)F)COC2=C(C=C(C=C2)NC3=NC=NC(=C3)C4=CN=CC=C4)Cl	IC50 ~ 100000 nM	Poor binder
T14597	Erbb2 tyrosine kinase receptor	B36RXA	5-(2-(3-(6-Methoxy-1H-benzo[d]imidazol-2-yl)-1H-pyrazol-4-yl)vinyl)nicotinonitrile	Investigative	135620674	C19H14N6O	342.4	COC1=CC2=C(C=C1)N=C(N2)C3=C(C=NN3)/C=C/C4=CC(=CN=C4)C#N	IC50 ~ 100000 nM	Poor binder
T14597	Erbb2 tyrosine kinase receptor	B45GIE	1-Butyl-1-(2-hydroxy-5-methylbenzyl)-3-phenylurea	Investigative	46229461	C19H24N2O2	312.4	CCCCN(CC1=CC=CC(=C1O)C)C(=O)NC2=CC=CC=C2	IC50 ~ 50000 nM	Poor binder
T14597	Erbb2 tyrosine kinase receptor	B49VLE	3-(4-(Dimethylamino)benzylidene)-1,3-dihydro-2H-indol-2-one	Investigative	6450842	C17H16N2O	264.32	CN(C)C1=CC=C(C=C1)/C=C\\2/C3=CC=CC=C3NC2=O	IC50 ~ 100000 nM	Poor binder
T14597	Erbb2 tyrosine kinase receptor	B4JU8K	4-Amino-6-(4-(benzyloxy)-3-chlorophenylamino)-N-(2-methoxyethyl)pyrimidine-5-carboxamide	Investigative	25271513	C21H22ClN5O3	427.9	COCCNC(=O)C1=C(N=CN=C1NC2=CC(=C(C=C2)OCC3=CC=CC=C3)Cl)N	IC50 ~ 100000 nM	Poor binder
T14597	Erbb2 tyrosine kinase receptor	B5YNV2	6,6-Dimethyl-8-(1-(oxetan-3-yl)piperidin-4-yl)-11-oxo-6,11-dihydro-5H-benzo[b]carbazole-3-carbonitrile	Investigative	53357328	C27H27N3O2	425.5	CC1(C2=C(C=CC(=C2)C3CCN(CC3)C4COC4)C(=O)C5=C1NC6=C5C=CC(=C6)C#N)C	IC50 ~ 50000 nM	Poor binder
T14597	Erbb2 tyrosine kinase receptor	B5ZV0X	Tyrphostin deriv. 64	Investigative	5328778	C18H16N2O5	340.3	COC1=CC(=C(C=C1)NC(=O)/C(=C/C2=CC(=C(C=C2)O)O)/C#N)OC	IC50 = 165958.69 nM	Poor binder
T14597	Erbb2 tyrosine kinase receptor	B63CRF	3-(4-(Methoxymethyl)-1H-benzo[d]imidazol-2-yl)-5-(pyrimidin-5-yl)-1H-pyrazolo[3,4-b]pyridine	Investigative	136118034	C19H15N7O	357.4	COCC1=C2C(=CC=C1)NC(=N2)C3=C4C=C(C=NC4=NN3)C5=CN=CN=C5	IC50 ~ 100000 nM	Poor binder
T14597	Erbb2 tyrosine kinase receptor	B6C9FG	(3Z)-3-[(4-Bromophenyl)methylidene]-1H-indol-2-one	Investigative	964113	C15H10BrNO	300.15	C1=CC=C2C(=C1)/C(=C/C3=CC=C(C=C3)Br)/C(=O)N2	IC50 ~ 100000 nM	Poor binder
T14597	Erbb2 tyrosine kinase receptor	B6EQL2	(E)-N-[4-(3-Bromoanilino)quinazolin-6-yl]but-2-enamide	Investigative	5328982	C18H15BrN4O	383.2	C/C=C/C(=O)NC1=CC2=C(C=C1)N=CN=C2NC3=CC(=CC=C3)Br	IC50 = 91325 nM	Poor binder
T14597	Erbb2 tyrosine kinase receptor	B6JQ1V	3-[1-(4-Piperidin-1-yl-phenyl)-ethylidene]-1,3-dihydro-indol-2-one	Investigative	10663368	C21H22N2O	318.4	C/C(=C\\1/C2=CC=CC=C2NC1=O)/C3=CC=C(C=C3)N4CCCCC4	IC50 ~ 100000 nM	Poor binder
T14597	Erbb2 tyrosine kinase receptor	B6LZ5N	3-(4-Dimethylamino-benzylidene)-4-methyl-1,3-dihydro-indol-2-one	Investigative	10755069	C18H18N2O	278.3	CC1=C\\2C(=CC=C1)NC(=O)/C2=C\\C3=CC=C(C=C3)N(C)C	IC50 ~ 100000 nM	Poor binder
T14597	Erbb2 tyrosine kinase receptor	B6PE8I	2-[(6-Chloro-1H-benzimidazol-2-yl)methyl]-5-(2,4-dichlorophenyl)-1,3,4-oxadiazole	Investigative	137656424	C16H9Cl3N4O	379.6	C1=CC(=C(C=C1Cl)Cl)C2=NN=C(O2)CC3=NC4=C(N3)C=C(C=C4)Cl	IC50 = 52600 nM	Poor binder
T14597	Erbb2 tyrosine kinase receptor	B6Y0JZ	3-[5-[(E)-3-Amino-2-cyano-3-oxoprop-1-enyl]-2-hydroxy-3-methoxyphenyl]sulfanylpropanoic acid	Investigative	44361708	C14H14N2O5S	322.34	COC1=C(C(=CC(=C1)/C=C(\\C#N)/C(=O)N)SCCC(=O)O)O	IC50 = 91201.08 nM	Poor binder
T14597	Erbb2 tyrosine kinase receptor	B73KFE	6-Bromo-N-(3-methoxyphenyl)-9H-pyrido[2,3-b]indol-4-amine	Investigative	76318470	C18H14BrN3O	368.2	COC1=CC=CC(=C1)NC2=C3C4=C(C=CC(=C4)Br)NC3=NC=C2	IC50 = 91200 nM	Poor binder
T14597	Erbb2 tyrosine kinase receptor	B74OWN	3-[1-(4-Piperidin-1-yl-phenyl)-meth-(Z)-ylidene]-1,3-dihydro-indol-2-one	Investigative	9948410	C20H20N2O	304.4	C1CCN(CC1)C2=CC=C(C=C2)/C=C\\3/C4=CC=CC=C4NC3=O	IC50 = 92600 nM	Poor binder
T14597	Erbb2 tyrosine kinase receptor	B78RHA	(3Z)-3-[4-(Morpholin-4-yl)benzylidene]-1,3-dihydro-2H-indol-2-one	Investigative	2379240	C19H18N2O2	306.4	C1COCCN1C2=CC=C(C=C2)/C=C\\3/C4=CC=CC=C4NC3=O	IC50 ~ 100000 nM	Poor binder
T14597	Erbb2 tyrosine kinase receptor	B7BQL9	3-(4-(Methoxymethyl)-1H-benzo[d]imidazol-2-yl)-5-(pyridin-3-yl)-1H-pyrazolo[3,4-b]pyridine	Investigative	135497879	C20H16N6O	356.4	COCC1=C2C(=CC=C1)NC(=N2)C3=C4C=C(C=NC4=NN3)C5=CN=CC=C5	IC50 ~ 100000 nM	Poor binder
T14597	Erbb2 tyrosine kinase receptor	B7SR2T	1-Butyl-1-(2-hydroxy-3,5-dimethylbenzyl)-3-phenylurea	Investigative	46229464	C20H26N2O2	326.4	CCCCN(CC1=CC(=CC(=C1O)C)C)C(=O)NC2=CC=CC=C2	IC50 ~ 50000 nM	Poor binder
T14597	Erbb2 tyrosine kinase receptor	B7TOG3	5-Nitro-3-(1H-pyrrol-2-ylmethylene)-1,3-dihydro-indol-2-one	Investigative	10658651	C13H9N3O3	255.23	C1=CNC(=C1)/C=C\\2/C3=C(C=CC(=C3)[N+](=O)[O-])NC2=O	IC50 ~ 100000 nM	Poor binder
T14597	Erbb2 tyrosine kinase receptor	B81XSU	1-Butyl-1-(3,5-dibromo-2-hydroxybenzyl)-3-phenylthiourea	Investigative	46229566	C18H20Br2N2OS	472.2	CCCCN(CC1=C(C(=CC(=C1)Br)Br)O)C(=S)NC2=CC=CC=C2	IC50 ~ 50000 nM	Poor binder
T14597	Erbb2 tyrosine kinase receptor	B8A6BQ	4-(3,4-Dimethoxyphenyl)-5-cyano-2H-1,2,3-triazole	Investigative	44437846	C11H10N4O2	230.22	COC1=C(C=C(C=C1)C2=NNN=C2C#N)OC	IC50 ~ 50000 nM	Poor binder
T14597	Erbb2 tyrosine kinase receptor	B8AK4E	N-((2-(5-(Isoquinolin-4-yl)-1H-pyrazolo[3,4-b]pyridin-3-yl)-1H-benzo[d]imidazol-4-yl)methyl)propan-2-amine	Investigative	135497865	C26H23N7	433.5	CC(C)NCC1=C2C(=CC=C1)NC(=N2)C3=C4C=C(C=NC4=NN3)C5=CN=CC6=CC=CC=C65	IC50 ~ 100000 nM	Poor binder
T14597	Erbb2 tyrosine kinase receptor	B8LI9R	N-(3-Ethoxyphenyl)-6-morpholin-4-ylsulfonyl-9H-pyrido[2,3-b]indol-4-amine	Investigative	76318467	C23H24N4O4S	452.5	CCOC1=CC=CC(=C1)NC2=C3C4=C(C=CC(=C4)S(=O)(=O)N5CCOCC5)NC3=NC=C2	IC50 = 54800 nM	Poor binder
T14597	Erbb2 tyrosine kinase receptor	B8LJS5	3-(5-Methyl-furan-2-ylmethylene)-1,3-dihydro-indol-2-one	Investigative	2358462	C14H11NO2	225.24	CC1=CC=C(O1)/C=C/2\\C3=CC=CC=C3NC2=O	IC50 ~ 100000 nM	Poor binder
T14597	Erbb2 tyrosine kinase receptor	B8N9VS	(3Z)-4-Methyl-3-(1H-pyrrol-2-ylmethylidene)-2,3-dihydro-1H-indol-2-one	Investigative	10489322	C14H12N2O	224.26	CC1=C\\2C(=CC=C1)NC(=O)/C2=C\\C3=CC=CN3	IC50 ~ 100000 nM	Poor binder
T14597	Erbb2 tyrosine kinase receptor	B8USO3	3-[(Z)-(3-Bromo-2-thienyl)methylidene]-1H-indol-2-one	Investigative	5707304	C13H8BrNOS	306.18	C1=CC=C2C(=C1)/C(=C/C3=C(C=CS3)Br)/C(=O)N2	IC50 ~ 100000 nM	Poor binder
T14597	Erbb2 tyrosine kinase receptor	B8YTQ3	CID 49806721	Investigative	49806721	C28H30N4O2	454.6	CCC1=CC2=C(C=C1N3CCN(CC3)C4COC4)C(C5=C(C2=O)C6=C(N5)C=C(C=C6)C#N)(C)C	IC50 ~ 50000 nM	Poor binder
T14597	Erbb2 tyrosine kinase receptor	B97WVX	N-((5-(3-(4-(Methoxymethyl)-1H-benzo[d]imidazol-2-yl)-1H-pyrazolo[3,4-b]pyridin-5-yl)-4-methylpyridin-3-yl)methyl)ethanamine	Investigative	135497794	C24H25N7O	427.5	CCNCC1=CN=CC(=C1C)C2=CC3=C(NN=C3N=C2)C4=NC5=C(C=CC=C5N4)COC	IC50 ~ 100000 nM	Poor binder
T14597	Erbb2 tyrosine kinase receptor	B9BWT8	N-(3-Chloro-4-(3-fluorobenzyloxy)phenyl)-5-methyl-6-phenylpyrimidin-4-amine	Investigative	53324200	C24H19ClFN3O	419.9	CC1=C(N=CN=C1NC2=CC(=C(C=C2)OCC3=CC(=CC=C3)F)Cl)C4=CC=CC=C4	IC50 = 65000 nM	Poor binder
T14597	Erbb2 tyrosine kinase receptor	B9CR8E	4-(2,3-Dimethoxyphenyl)-5-cyano-2H-1,2,3-triazole	Investigative	44437845	C11H10N4O2	230.22	COC1=CC=CC(=C1OC)C2=NNN=C2C#N	IC50 ~ 50000 nM	Poor binder
T14597	Erbb2 tyrosine kinase receptor	BACY73	(3Z)-3-(4-Hydroxybenzylidene)-1,3-dihydro-2H-indol-2-one	Investigative	5874584	C15H11NO2	237.25	C1=CC=C2C(=C1)/C(=C/C3=CC=C(C=C3)O)/C(=O)N2	IC50 ~ 100000 nM	Poor binder
T14597	Erbb2 tyrosine kinase receptor	BBET67	5-Phenyl-3H-[1,2,3]triazole-4-carbonitrile	Investigative	12175099	C9H6N4	170.17	C1=CC=C(C=C1)C2=NNN=C2C#N	IC50 = 53500 nM	Poor binder
T14597	Erbb2 tyrosine kinase receptor	BBT6N5	5-(4-Methoxyphenyl)-2H-1,2,3-triazole-4-carbonitrile	Investigative	5076757	C10H8N4O	200.2	COC1=CC=C(C=C1)C2=NNN=C2C#N	IC50 ~ 50000 nM	Poor binder
T14597	Erbb2 tyrosine kinase receptor	BC5JX0	Tyrphostin deriv. 54	Investigative	5328774	C16H11ClN2O3	314.72	C1=CC=C(C(=C1)NC(=O)/C(=C/C2=CC(=C(C=C2)O)O)/C#N)Cl	IC50 = 57000 nM	Poor binder
T14597	Erbb2 tyrosine kinase receptor	BC87JM	(Z)-4-Methyl-3-(4-morpholinobenzylidene)indolin-2-one	Investigative	10663503	C20H20N2O2	320.4	CC1=C\\2C(=CC=C1)NC(=O)/C2=C\\C3=CC=C(C=C3)N4CCOCC4	IC50 = 66600 nM	Poor binder
T14597	Erbb2 tyrosine kinase receptor	BC8U1N	4-Amino-6-(4-(benzyloxy)-3-chlorophenylamino)-N-(4-methoxyphenyl)pyrimidine-5-carboxamide	Investigative	25271518	C25H22ClN5O3	475.9	COC1=CC=C(C=C1)NC(=O)C2=C(N=CN=C2NC3=CC(=C(C=C3)OCC4=CC=CC=C4)Cl)N	IC50 ~ 100000 nM	Poor binder
T14597	Erbb2 tyrosine kinase receptor	BC9U7X	(3Z)-3-[(4-Methoxyphenyl)methylidene]-1H-indol-2-one	Investigative	727518	C16H13NO2	251.28	COC1=CC=C(C=C1)/C=C\\2/C3=CC=CC=C3NC2=O	IC50 ~ 100000 nM	Poor binder
T14597	Erbb2 tyrosine kinase receptor	BCU8O3	(E)-2-(2-Methyl-5-nitro-1H-imidazol-1-yl)ethyl 3-(2-methoxyphenyl)acrylate	Investigative	49799785	C16H17N3O5	331.32	CC1=NC=C(N1CCOC(=O)/C=C/C2=CC=CC=C2OC)[N+](=O)[O-]	IC50 ~ 50000 nM	Poor binder
T14597	Erbb2 tyrosine kinase receptor	BCV80X	3-(3,5-Di-tert-butyl-4-hydroxybenzylidene)indolin-2-one	Investigative	9884745	C23H27NO2	349.5	CC(C)(C)C1=CC(=CC(=C1O)C(C)(C)C)/C=C\\2/C3=CC=CC=C3NC2=O	IC50 = 64800 nM	Poor binder
T14597	Erbb2 tyrosine kinase receptor	BCX9K5	4-(3-(4-(Methoxymethyl)-1H-benzo[d]imidazol-2-yl)-1-methyl-1H-pyrazolo[3,4-b]pyridin-5-yl)isoquinoline	Investigative	136118031	C25H20N6O	420.5	CN1C2=C(C=C(C=N2)C3=CN=CC4=CC=CC=C43)C(=N1)C5=NC6=C(C=CC=C6N5)COC	IC50 ~ 100000 nM	Poor binder
T14597	Erbb2 tyrosine kinase receptor	BD01AP	4-Methyl-3-(5-methylsulfanyl-thiophen-2-ylmethylene)-1,3-dihydro-indol-2-one	Investigative	10779668	C15H13NOS2	287.4	CC1=C\\2C(=CC=C1)NC(=O)/C2=C\\C3=CC=C(S3)SC	IC50 = 91400 nM	Poor binder
T14597	Erbb2 tyrosine kinase receptor	BD05ME	(Z)-4-(4-((4-Methyl-2-oxoindolin-3-ylidene)methyl)phenyl)piperazine-1-carbaldehyde	Investigative	10593765	C21H21N3O2	347.4	CC1=C\\2C(=CC=C1)NC(=O)/C2=C\\C3=CC=C(C=C3)N4CCN(CC4)C=O	IC50 ~ 100000 nM	Poor binder
T14597	Erbb2 tyrosine kinase receptor	BD17KR	(3Z)-3-[(4-Chloro-1-methylpyrazol-3-yl)methylidene]-1H-indol-2-one	Investigative	136026516	C13H10ClN3O	259.69	CN1C=C(C(=N1)/C=C\\2/C3=CC=CC=C3NC2=O)Cl	IC50 ~ 100000 nM	Poor binder
T14597	Erbb2 tyrosine kinase receptor	BD26EW	3-Fluorobenzyl 4-amino-6-(4-(benzyloxy)-3-chlorophenylamino)pyrimidine-5-carboxylate	Investigative	25271180	C25H20ClFN4O3	478.9	C1=CC=C(C=C1)COC2=C(C=C(C=C2)NC3=NC=NC(=C3C(=O)OCC4=CC(=CC=C4)F)N)Cl	IC50 ~ 100000 nM	Poor binder
T14597	Erbb2 tyrosine kinase receptor	BD2QN0	2-(1H-Benzimidazol-2-ylmethyl)-5-(phenoxymethyl)-1,3,4-oxadiazole	Investigative	137642492	C17H14N4O2	306.32	C1=CC=C(C=C1)OCC2=NN=C(O2)CC3=NC4=CC=CC=C4N3	IC50 = 52400 nM	Poor binder
T14597	Erbb2 tyrosine kinase receptor	BD60GI	2-(3,4-Dihydroxy-5-methylbenzylidene)malononitrile	Investigative	9899125	C11H8N2O2	200.19	CC1=CC(=CC(=C1O)O)C=C(C#N)C#N	IC50 = 58884.37 nM	Poor binder
T14597	Erbb2 tyrosine kinase receptor	BDB2U4	3-[1-(5-Ethyl-thiophen-2-yl)-meth-(Z)-ylidene]-1,3-dihydro-indol-2-one	Investigative	10682457	C15H13NOS	255.3	CCC1=CC=C(S1)/C=C\\2/C3=CC=CC=C3NC2=O	IC50 ~ 100000 nM	Poor binder
T14597	Erbb2 tyrosine kinase receptor	BDXT45	3-(1H-Indol-3-yl)-4-(3,4,5-trimethoxyphenyl)pyrrole-2,5-dione	Investigative	11530963	C21H18N2O5	378.4	COC1=CC(=CC(=C1OC)OC)C2=C(C(=O)NC2=O)C3=CNC4=CC=CC=C43	IC50 = 50000 nM	Poor binder
T14597	Erbb2 tyrosine kinase receptor	BE0BU2	1-(5-Bromo-2-hydroxybenzyl)-1-butyl-3-phenylurea	Investigative	46229460	C18H21BrN2O2	377.3	CCCCN(CC1=C(C(=CC=C1)Br)O)C(=O)NC2=CC=CC=C2	IC50 ~ 50000 nM	Poor binder
T14597	Erbb2 tyrosine kinase receptor	BEJA95	1-Butyl-1-(2-hydroxy-5-methylbenzyl)-3-phenylthiourea	Investigative	46229539	C19H24N2OS	328.5	CCCCN(CC1=CC=CC(=C1O)C)C(=S)NC2=CC=CC=C2	IC50 ~ 50000 nM	Poor binder
T14597	Erbb2 tyrosine kinase receptor	BEW72O	2-Methoxy-6-(decahydronaphthalene-1-ylidenemethyl)-1,4-benzoquinone	Investigative	11129889	C18H22O3	286.4	COC1=CC(=O)C=C(C1=O)/C=C/2\\CCCC3C2CCCC3	IC50 ~ 100000 nM	Poor binder
T14597	Erbb2 tyrosine kinase receptor	BF21PJ	1-Butyl-1-(3,5-dichloro-2-hydroxybenzyl)-3-phenylturea	Investigative	46229462	C18H20Cl2N2O2	367.3	CCCCN(CC1=C(C(=CC(=C1)Cl)Cl)O)C(=O)NC2=CC=CC=C2	IC50 ~ 50000 nM	Poor binder
T14597	Erbb2 tyrosine kinase receptor	BFK2W1	(3E)-3-(Furan-2-ylmethylidene)-1H-indol-2-one	Investigative	5713379	C13H9NO2	211.22	C1=CC=C2C(=C1)/C(=C\\C3=CC=CO3)/C(=O)N2	IC50 ~ 100000 nM	Poor binder
T14597	Erbb2 tyrosine kinase receptor	BFQR96	3-(3,5-Dimethyl-1H-pyrrol-2-ylmethylene)-4-methyl-1,3-dihydro-indol-2-one	Investigative	10264222	C16H16N2O	252.31	CC1=C\\2C(=CC=C1)NC(=O)/C2=C\\C3=C(C=C(N3)C)C	IC50 ~ 100000 nM	Poor binder
T14597	Erbb2 tyrosine kinase receptor	BFS3W8	3-(3-(4-(Methoxymethyl)-1H-benzo[d]imidazol-2-yl)-1H-pyrazolo[3,4-b]pyridin-5-yl)quinoline	Investigative	135497878	C24H18N6O	406.4	COCC1=C2C(=CC=C1)NC(=N2)C3=C4C=C(C=NC4=NN3)C5=CC6=CC=CC=C6N=C5	IC50 ~ 100000 nM	Poor binder
T14597	Erbb2 tyrosine kinase receptor	BG3H5V	4-(Bis(2-chloroethyl)amino)-N-(3-morpholinopropyl)benzamide	Investigative	46207015	C18H27Cl2N3O2	388.3	C1COCCN1CCCNC(=O)C2=CC=C(C=C2)N(CCCl)CCCl	IC50 ~ 50000 nM	Poor binder
T14597	Erbb2 tyrosine kinase receptor	BG5LM7	4-Amino-6-(4-(benzyloxy)-3-chlorophenylamino)-N,N-diethylpyrimidine-5-carboxamide	Investigative	25271181	C22H24ClN5O2	425.9	CCN(CC)C(=O)C1=C(N=CN=C1NC2=CC(=C(C=C2)OCC3=CC=CC=C3)Cl)N	IC50 ~ 100000 nM	Poor binder
T14597	Erbb2 tyrosine kinase receptor	BI4HE0	N-(4-Bromo-2-fluorophenyl)-6-methoxy-7-[2-(triazol-1-yl)ethoxy]quinazolin-4-amine	Investigative	5329032	C19H16BrFN6O2	459.3	COC1=C(C=C2C(=C1)C(=NC=N2)NC3=C(C=C(C=C3)Br)F)OCCN4C=CN=N4	IC50 ~ 100000 nM	Poor binder
T14597	Erbb2 tyrosine kinase receptor	BI4JU2	6-Fluoro-3-[1-(1H-pyrrol-2-yl)-meth-(Z)-ylidene]-1,3-dihydro-indol-2-one	Investigative	10728035	C13H9FN2O	228.22	C1=CNC(=C1)/C=C\\2/C3=C(C=C(C=C3)F)NC2=O	IC50 ~ 100000 nM	Poor binder
T14597	Erbb2 tyrosine kinase receptor	BL0BS7	4-(3,4,5-Trimethoxyphenyl)-5-cyano-2H-1,2,3-triazole	Investigative	44437847	C12H12N4O3	260.25	COC1=CC(=CC(=C1OC)OC)C2=NNN=C2C#N	IC50 ~ 50000 nM	Poor binder
T14597	Erbb2 tyrosine kinase receptor	BL3J7V	3-(3,5-Dimethyl-1H-pyrrol-2-ylmethylene)-5-methyl-1,3-dihydro-indol-2-one	Investigative	10562777	C16H16N2O	252.31	CC1=CC\\2=C(C=C1)NC(=O)/C2=C\\C3=C(C=C(N3)C)C	IC50 ~ 100000 nM	Poor binder
T14597	Erbb2 tyrosine kinase receptor	BL9GC2	4-(Bis(2-chloroethyl)amino)-N-dodecylbenzamide	Investigative	46207037	C23H38Cl2N2O	429.5	CCCCCCCCCCCCNC(=O)C1=CC=C(C=C1)N(CCCl)CCCl	IC50 ~ 50000 nM	Poor binder
T14597	Erbb2 tyrosine kinase receptor	BLB49J	4-[[6-Amino-4-butoxy-5-(2,6-difluorobenzoyl)pyridin-2-yl]amino]benzenesulfonamide	Investigative	5330847	C22H22F2N4O4S	476.5	CCCCOC1=CC(=NC(=C1C(=O)C2=C(C=CC=C2F)F)N)NC3=CC=C(C=C3)S(=O)(=O)N	IC50 ~ 100000 nM	Poor binder
T14597	Erbb2 tyrosine kinase receptor	BLN69O	3-Acyl-2,6-diaminopyridine deriv. 2p	Investigative	5330830	C20H18F2N4O3S	432.4	CN(C)S(=O)(=O)C1=CC=C(C=C1)NC2=NC(=C(C=C2)C(=O)C3=C(C=CC=C3F)F)N	IC50 ~ 100000 nM	Poor binder
T14597	Erbb2 tyrosine kinase receptor	BM59RL	3-[1-(4-Chloro-1H-pyrazol-3-yl)-meth-(Z)-ylidene]-1,3-dihydro-indol-2-one	Investigative	135536640	C12H8ClN3O	245.66	C1=CC=C2C(=C1)/C(=C/C3=C(C=NN3)Cl)/C(=O)N2	IC50 ~ 100000 nM	Poor binder
T14597	Erbb2 tyrosine kinase receptor	BMBP07	4-[2-Oxo-1,2-dihydro-indol-(3Z)-ylidenemethyl]-benzoic acid	Investigative	2365265	C16H11NO3	265.26	C1=CC=C2C(=C1)/C(=C/C3=CC=C(C=C3)C(=O)O)/C(=O)N2	IC50 ~ 100000 nM	Poor binder
T14597	Erbb2 tyrosine kinase receptor	BMWZ60	Tyrphostin deriv. 39	Investigative	5328767	C19H17NO3	307.3	CC1=CC(=C(C(=C1)C)C(=O)/C(=C/C2=CC(=C(C=C2)O)O)/C#N)C	IC50 = 50000 nM	Poor binder
T14597	Erbb2 tyrosine kinase receptor	BN3Y0E	3-[[5-Cyano-6-(cyclopentylamino)pyrimidin-4-yl]amino]-4-methyl-N-(1,2-oxazol-3-yl)benzamide	Investigative	11235063	C21H21N7O2	403.4	CC1=C(C=C(C=C1)C(=O)NC2=NOC=C2)NC3=C(C(=NC=N3)NC4CCCC4)C#N	IC50 ~ 50000 nM	Poor binder
T14597	Erbb2 tyrosine kinase receptor	BN47UZ	3-[1-(3,4-Dimethyl-1H-pyrrol-2-yl)-meth-(Z)-ylidene]-1,3-dihydro-indol-2-one	Investigative	10236164	C15H14N2O	238.28	CC1=CNC(=C1C)/C=C\\2/C3=CC=CC=C3NC2=O	IC50 ~ 100000 nM	Poor binder
T14597	Erbb2 tyrosine kinase receptor	BNF30J	1-Butyl-1-(2-hydroxy-3,5-dimethylbenzyl)-3-phenylthiourea	Investigative	46229567	C23H24N2OS	376.5	CC1=CC(=C(C(=C1)CN(CC2=CC=CC=C2)C(=S)NC3=CC=CC=C3)O)C	IC50 ~ 50000 nM	Poor binder
T14597	Erbb2 tyrosine kinase receptor	BO3X7G	4-(2-(3-(6-Methoxy-1H-benzo[d]imidazol-2-yl)-1H-pyrazol-4-yl)vinyl)isoquinoline	Investigative	135620680	C22H17N5O	367.4	COC1=CC2=C(C=C1)N=C(N2)C3=C(C=NN3)/C=C/C4=CN=CC5=CC=CC=C54	IC50 ~ 100000 nM	Poor binder
T14597	Erbb2 tyrosine kinase receptor	BO4LZ9	3-(2-(3-(4-(Trifluoromethyl)-1H-imidazol-2-yl)-1H-pyrazol-4-yl)vinyl)pyridine	Investigative	136104460	C14H10F3N5	305.26	C1=CC(=CN=C1)/C=C/C2=C(NN=C2)C3=NC=C(N3)C(F)(F)F	IC50 ~ 100000 nM	Poor binder
T14597	Erbb2 tyrosine kinase receptor	BO5R7P	3-(5-Ethyl-furan-2-ylmethylene)-1,3-dihydro-indol-2-one	Investigative	10537949	C15H13NO2	239.27	CCC1=CC=C(O1)/C=C/2\\C3=CC=CC=C3NC2=O	IC50 ~ 100000 nM	Poor binder
T14597	Erbb2 tyrosine kinase receptor	BPLJ98	(3Z)-3-[[4-(Dimethylamino)phenyl]methylidene]-6-fluoro-1H-indol-2-one	Investigative	44321717	C17H15FN2O	282.31	CN(C)C1=CC=C(C=C1)/C=C\\2/C3=C(C=C(C=C3)F)NC2=O	IC50 ~ 100000 nM	Poor binder
T14597	Erbb2 tyrosine kinase receptor	BQ4YP0	Methyl 3-[4-methyl-5-[(Z)-(2-oxo-1H-indol-3-ylidene)methyl]-1H-pyrrol-3-yl]propanoate	Investigative	10215023	C18H18N2O3	310.3	CC1=C(NC=C1CCC(=O)OC)/C=C\\2/C3=CC=CC=C3NC2=O	IC50 ~ 100000 nM	Poor binder
T14597	Erbb2 tyrosine kinase receptor	BQ75AN	4-(3-(5-Morpholino-1H-benzo[d]imidazol-2-yl)-1H-pyrazolo[3,4-b]pyridin-5-yl)isoquinoline	Investigative	135497787	C26H21N7O	447.5	C1COCCN1C2=CC3=C(C=C2)N=C(N3)C4=C5C=C(C=NC5=NN4)C6=CN=CC7=CC=CC=C76	IC50 ~ 100000 nM	Poor binder
T14597	Erbb2 tyrosine kinase receptor	BQTO97	N-(4-Methoxyphenethyl)-4-amino-6-(4-(benzyloxy)-3-chlorophenylamino)pyrimidine-5-carboxamide	Investigative	25271516	C27H26ClN5O3	504	COC1=CC=C(C=C1)CCNC(=O)C2=C(N=CN=C2NC3=CC(=C(C=C3)OCC4=CC=CC=C4)Cl)N	IC50 ~ 100000 nM	Poor binder
T14597	Erbb2 tyrosine kinase receptor	BQW0B2	(3Z)-3-[(5-Methylsulfanylthiophen-2-yl)methylidene]-1H-indol-2-one	Investigative	10636005	C14H11NOS2	273.4	CSC1=CC=C(S1)/C=C\\2/C3=CC=CC=C3NC2=O	IC50 ~ 100000 nM	Poor binder
T14597	Erbb2 tyrosine kinase receptor	BQW81G	(3Z)-3-[(3,5-Dimethyl-1H-pyrrol-2-yl)methylidene]-6-fluoro-1H-indol-2-one	Investigative	10753550	C15H13FN2O	256.269	CC1=CC(=C(N1)/C=C\\2/C3=C(C=C(C=C3)F)NC2=O)C	IC50 ~ 100000 nM	Poor binder
T14597	Erbb2 tyrosine kinase receptor	BQX9A6	N-Cyclopropyl-2,4-difluoro-5-((2-(pyridin-2-ylamino)thiazol-5-yl)methylamino)benzamide	Investigative	11632737	C19H17F2N5OS	401.4	C1CC1NC(=O)C2=CC(=C(C=C2F)F)NCC3=CN=C(S3)NC4=CC=CC=N4	IC50 ~ 50000 nM	Poor binder
T14597	Erbb2 tyrosine kinase receptor	BRP6V7	4-[[6-Amino-5-(2,6-difluorobenzoyl)pyridin-2-yl]amino]benzenesulfonamide	Investigative	5330832	C18H14F2N4O3S	404.4	C1=CC(=C(C(=C1)F)C(=O)C2=C(N=C(C=C2)NC3=CC=C(C=C3)S(=O)(=O)N)N)F	IC50 ~ 100000 nM	Poor binder
T14597	Erbb2 tyrosine kinase receptor	BRY87X	2-(4-Methoxyphenyl)-N-(4-methylphenyl)sulfonylacetamide	Investigative	56670200	C16H17NO4S	319.4	CC1=CC=C(C=C1)S(=O)(=O)NC(=O)CC2=CC=C(C=C2)OC	IC50 ~ 50000 nM	Poor binder
T14597	Erbb2 tyrosine kinase receptor	BSC9A5	5-Chloro-3-(1H-pyrrol-2-ylmethylene)-1,3-dihydro-indol-2-one	Investigative	10562306	C13H9ClN2O	244.67	C1=CNC(=C1)/C=C\\2/C3=C(C=CC(=C3)Cl)NC2=O	IC50 ~ 100000 nM	Poor binder
T14597	Erbb2 tyrosine kinase receptor	BT1HK6	1-Butyl-1-(3,5-dibromo-2-hydroxybenzyl)-3-phenylurea	Investigative	46229463	C18H20Br2N2O2	456.2	CCCCN(CC1=C(C(=CC(=C1)Br)Br)O)C(=O)NC2=CC=CC=C2	IC50 ~ 50000 nM	Poor binder
T14597	Erbb2 tyrosine kinase receptor	BT9P8Q	2-(4-(2-(Pyridin-3-yl)vinyl)-1H-pyrazol-3-yl)-1H-imidazole-4-carbonitrile	Investigative	135922390	C14H10N6	262.27	C1=CC(=CN=C1)/C=C/C2=C(NN=C2)C3=NC=C(N3)C#N	IC50 ~ 100000 nM	Poor binder
T14597	Erbb2 tyrosine kinase receptor	BTQ1Z0	(5-(3-(4-(Methoxymethyl)-1H-benzo[d]imidazol-2-yl)-1H-pyrazolo[3,4-b]pyridin-5-yl)pyridin-3-yl)-N-methylmethanamine	Investigative	135497791	C22H21N7O	399.4	CNCC1=CC(=CN=C1)C2=CC3=C(NN=C3N=C2)C4=NC5=C(C=CC=C5N4)COC	IC50 ~ 100000 nM	Poor binder
T14597	Erbb2 tyrosine kinase receptor	BTQK89	3-[1-(4-Pyrrolidin-1-yl-phenyl)-meth-(Z)-ylidene]-1,3-dihydro-indol-2-one	Investigative	5427216	C19H18N2O	290.4	C1CCN(C1)C2=CC=C(C=C2)/C=C\\3/C4=CC=CC=C4NC3=O	IC50 ~ 100000 nM	Poor binder
T14597	Erbb2 tyrosine kinase receptor	BU5E9W	(3Z)-3-[(1-Methylpyrrol-2-yl)methylidene]-1H-indol-2-one	Investigative	6536705	C14H12N2O	224.26	CN1C=CC=C1/C=C\\2/C3=CC=CC=C3NC2=O	IC50 ~ 100000 nM	Poor binder
T14597	Erbb2 tyrosine kinase receptor	BUSW18	N-(4-(4-Amino-7-((1s,4s)-4-(4-methylpiperazin-1-yl)cyclohexyl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-2-fluorophenyl)-5,7-dimethylbenzo[d]oxazol-2-amine	Investigative	52950015	C31H34BrFN8O	633.6	CC1=CC2=C(C(=C1)Br)OC(=N2)NC3=C(C=C(C=C3)C4=CN(C5=NC=NC(=C45)N)C6CCC(CC6)N7CCN(CC7)C)F	IC50 ~ 62500 nM	Poor binder
T14597	Erbb2 tyrosine kinase receptor	BV3L0I	N-(3-Chloro-4-(3-fluorobenzyloxy)phenyl)-6-(pyrrolidin-1-yl)pyrimidin-4-amine	Investigative	53317172	C21H20ClFN4O	398.9	C1CCN(C1)C2=NC=NC(=C2)NC3=CC(=C(C=C3)OCC4=CC(=CC=C4)F)Cl	IC50 ~ 100000 nM	Poor binder
T14597	Erbb2 tyrosine kinase receptor	BV95PD	(3Z)-3-[(3-Ethyl-4,5-dimethyl-1H-pyrrol-2-yl)methylidene]-1H-indol-2-one	Investigative	10635478	C17H18N2O	266.34	CCC1=C(NC(=C1C)C)/C=C\\2/C3=CC=CC=C3NC2=O	IC50 ~ 100000 nM	Poor binder
T14597	Erbb2 tyrosine kinase receptor	BX1A9W	(5-(3-(4-(Methoxymethyl)-1H-benzo[d]imidazol-2-yl)-1H-pyrazolo[3,4-b]pyridin-5-yl)pyridin-3-yl)-N,N-dimethylmethanamine	Investigative	136118035	C23H23N7O	413.5	CN(C)CC1=CC(=CN=C1)C2=CC3=C(NN=C3N=C2)C4=NC5=C(C=CC=C5N4)COC	IC50 ~ 100000 nM	Poor binder
T14597	Erbb2 tyrosine kinase receptor	BX5E6T	2-(5-Isoquinolin-4-yl-1H-pyrazolo[3,4-b]pyridin-3-yl)-1H-benzoimidazole-4-carboxylic acid methyl ester	Investigative	136118032	C24H16N6O2	420.4	COC(=O)C1=C2C(=CC=C1)NC(=N2)C3=C4C=C(C=NC4=NN3)C5=CN=CC6=CC=CC=C65	IC50 ~ 100000 nM	Poor binder
T14597	Erbb2 tyrosine kinase receptor	BXT54C	(3Z)-3-[(4-Ethyl-3,5-dimethyl-1H-pyrrol-2-yl)methylidene]-1H-indol-2-one	Investigative	10587839	C17H18N2O	266.34	CCC1=C(NC(=C1C)/C=C\\2/C3=CC=CC=C3NC2=O)C	IC50 ~ 100000 nM	Poor binder
T14597	Erbb2 tyrosine kinase receptor	BXZ23Y	N-((5-(2-(3-(4-(Trifluoromethyl)-1H-imidazol-2-yl)-1H-pyrazol-4-yl)vinyl)pyridin-3-yl)methyl)ethanamine	Investigative	135823061	C17H17F3N6	362.4	CCNCC1=CC(=CN=C1)/C=C/C2=C(NN=C2)C3=NC=C(N3)C(F)(F)F	IC50 ~ 100000 nM	Poor binder
T14597	Erbb2 tyrosine kinase receptor	BY47PQ	3-(4-(Methoxymethyl)-1H-benzo[d]imidazol-2-yl)-5-(pyridin-4-yl)-1H-pyrazolo[3,4-b]pyridine	Investigative	135497800	C20H16N6O	356.4	COCC1=C2C(=CC=C1)NC(=N2)C3=C4C=C(C=NC4=NN3)C5=CC=NC=C5	IC50 ~ 100000 nM	Poor binder
T14597	Erbb2 tyrosine kinase receptor	BY7MP5	5-(1H-Indol-3-yl)-3-(3,4,5-trimethoxyphenyl)-1H-pyrazin-2-one	Investigative	118723185	C21H19N3O4	377.4	COC1=CC(=CC(=C1OC)OC)C2=NC(=CNC2=O)C3=CNC4=CC=CC=C43	IC50 ~ 100000 nM	Poor binder
T14597	Erbb2 tyrosine kinase receptor	BZ87CG	8-(2,5-Dichlorophenylthio)-9H-purin-6-amine	Investigative	11289919	C11H7Cl2N5S	312.2	C1=CC(=C(C=C1Cl)SC2=NC3=NC=NC(=C3N2)N)Cl	IC50 = 120000 nM	Poor binder
T14597	Erbb2 tyrosine kinase receptor	BZ8WM4	4-Methyl-5-[2-oxo-1,2-dihydro-indol-(3Z)-ylidenemethyl]-1H-pyrrole-3-carboxylic acid ethyl ester	Investigative	10613858	C17H16N2O3	296.32	CCOC(=O)C1=CNC(=C1C)/C=C\\2/C3=CC=CC=C3NC2=O	IC50 ~ 100000 nM	Poor binder
T14597	Erbb2 tyrosine kinase receptor	BZYF42	2-Benzhydryl-5-(1H-benzimidazol-2-ylmethyl)-1,3,4-oxadiazole	Investigative	137661754	C23H18N4O	366.4	C1=CC=C(C=C1)C(C2=CC=CC=C2)C3=NN=C(O3)CC4=NC5=CC=CC=C5N4	IC50 = 57600 nM	Poor binder
T14597	Erbb2 tyrosine kinase receptor	D00ATA	(Z)-3-((1H-pyrrol-2-yl)methylene)indolin-2-one	Investigative	5908088	C13H10N2O	210.23	C1=CC=C2C(=C1)/C(=C/C3=CC=CN3)/C(=O)N2	IC50 ~ 100000 nM	Poor binder
T14597	Erbb2 tyrosine kinase receptor	D03ATU	PD-158780	Investigative	4707	C14H12BrN5	330.18	CNC1=NC=C2C(=C1)C(=NC=N2)NC3=CC(=CC=C3)Br	IC50 = 52000 nM	Poor binder
T14597	Erbb2 tyrosine kinase receptor	D07OSK	VEGF receptor 2 kinase inhibitor I	Investigative	6419834	C18H18N2O3	310.3	CCOC(=O)C1=C(NC(=C1C)/C=C\\2/C3=CC=CC=C3NC2=O)C	IC50 ~ 100000 nM	Poor binder
T14597	Erbb2 tyrosine kinase receptor	D0A4XJ	SU5402	Investigative	5289418	C17H16N2O3	296.32	CC1=CNC(=C1CCC(=O)O)/C=C\\2/C3=CC=CC=C3NC2=O	IC50 ~ 100000 nM	Poor binder
T14597	Erbb2 tyrosine kinase receptor	D0HE0E	SU4984	Investigative	5941540	C20H19N3O2	333.4	C1CN(CCN1C=O)C2=CC=C(C=C2)/C=C\\3/C4=CC=CC=C4NC3=O	IC50 = 90200 nM	Poor binder