TTD_Target_ID	Target_Name	TTD_Drug_ID	Drug_Name	Drug_Highest_Status	Drug_PubchemID	Molecular_Formula	Molecular_Weight	Canonical_SMILES	Activity	Binder_Type
T15776	Pyruvate dehydrogenase kinase 1	B2EW8I	3-(Phenylethynyl)-1H-indazole	Investigative	20644743	C15H10N2	218.25	C1=CC=C(C=C1)C#CC2=C3C=CC=CC3=NN2	IC50 ~ 50000 nM	Poor binder
T15776	Pyruvate dehydrogenase kinase 1	B3Q7NC	3-((3,5-Bis(trifluoromethyl)phenyl)ethynyl)-1Hindazole	Investigative	42606083	C17H8F6N2	354.25	C1=CC2=C(NN=C2C=C1)C#CC3=CC(=CC(=C3)C(F)(F)F)C(F)(F)F	IC50 ~ 100000 nM	Poor binder
T15776	Pyruvate dehydrogenase kinase 1	B61VGT	3-((3,5-Difluorophenyl)ethynyl)-1H-indazole	Investigative	42606079	C15H8F2N2	254.23	C1=CC2=C(NN=C2C=C1)C#CC3=CC(=CC(=C3)F)F	IC50 ~ 100000 nM	Poor binder
T15776	Pyruvate dehydrogenase kinase 1	B6JS7B	4-((1H-Indazol-3-yl)ethynyl)benzonitrile	Investigative	42606194	C16H9N3	243.26	C1=CC2=C(NN=C2C=C1)C#CC3=CC=C(C=C3)C#N	IC50 ~ 100000 nM	Poor binder
T15776	Pyruvate dehydrogenase kinase 1	B7MO4E	4-[6-(Cyclopropylmethylamino)imidazo[1,2-b]pyridazin-3-yl]-N-[2-(dimethylamino)ethyl]benzamide	Investigative	24959046	C21H26N6O	378.5	CN(C)CCNC(=O)C1=CC=C(C=C1)C2=CN=C3N2N=C(C=C3)NCC4CC4	IC50 ~ 100000 nM	Poor binder
T15776	Pyruvate dehydrogenase kinase 1	BA59TB	3-(Thiophen-3-ylethynyl)-1H-indazole	Investigative	42606190	C13H8N2S	224.28	C1=CC2=C(NN=C2C=C1)C#CC3=CSC=C3	IC50 ~ 100000 nM	Poor binder
T15776	Pyruvate dehydrogenase kinase 1	BGEP17	3-[3-(Dimethylamino)-1-propynyl]-1H-indazole	Investigative	49852123	C12H13N3	199.25	CN(C)CC#CC1=C2C=CC=CC2=NN1	IC50 ~ 100000 nM	Poor binder
T15776	Pyruvate dehydrogenase kinase 1	BGO48R	3-(Pyridin-4-ylethynyl)-1H-pyrazolo[3,4-b]pyridine	Investigative	42606431	C13H8N4	220.23	C1=CC2=C(NN=C2N=C1)C#CC3=CC=NC=C3	IC50 ~ 50000 nM	Poor binder
T15776	Pyruvate dehydrogenase kinase 1	BNMX13	2-((1H-Indazol-3-yl)ethynyl)aniline	Investigative	21048651	C15H11N3	233.27	C1=CC=C(C(=C1)C#CC2=C3C=CC=CC3=NN2)N	IC50 ~ 100000 nM	Poor binder
T15776	Pyruvate dehydrogenase kinase 1	BPO9D8	4-[6-[(3,4-Dichlorophenyl)methylamino]imidazo[1,2-b]pyridazin-3-yl]-N-(2-pyrrolidin-1-ylethyl)benzamide	Investigative	49864785	C26H26Cl2N6O	509.4	C1CCN(C1)CCNC(=O)C2=CC=C(C=C2)C3=CN=C4N3N=C(C=C4)NCC5=CC(=C(C=C5)Cl)Cl	IC50 ~ 100000 nM	Poor binder
T15776	Pyruvate dehydrogenase kinase 1	BQTP35	3-(Cyclopropylethynyl)-1H-indazole	Investigative	42606195	C12H10N2	182.22	C1CC1C#CC2=C3C=CC=CC3=NN2	IC50 ~ 100000 nM	Poor binder
T15776	Pyruvate dehydrogenase kinase 1	BQUZ09	4-[6-[(3-Chlorophenyl)methylamino]imidazo[1,2-b]pyridazin-3-yl]-N-[[(2S)-pyrrolidin-2-yl]methyl]benzamide	Investigative	49865153	C25H25ClN6O	461	C1C[C@H](NC1)CNC(=O)C2=CC=C(C=C2)C3=CN=C4N3N=C(C=C4)NCC5=CC(=CC=C5)Cl	IC50 ~ 100000 nM	Poor binder
T15776	Pyruvate dehydrogenase kinase 1	BT5H2Q	3-(Cyclopentylethynyl)-1H-indazole	Investigative	42606196	C14H14N2	210.27	C1CCC(C1)C#CC2=C3C=CC=CC3=NN2	IC50 ~ 100000 nM	Poor binder
T15776	Pyruvate dehydrogenase kinase 1	BTPM76	3-(Pyridin-2-ylethynyl)-1H-pyrazolo[3,4-b]pyridine	Investigative	49850583	C13H8N4	220.23	C1=CC(=CN=C1)C#CC2=C3C=CC=NC3=NN2	IC50 ~ 50000 nM	Poor binder
T15776	Pyruvate dehydrogenase kinase 1	BVDF78	(S)-4-(6-(Cyclopropylmethylamino)imidazo[1,2-b]pyridazin-3-yl)-N-(pyrrolidin-2-ylmethyl)benzamide	Investigative	46933384	C22H26N6O	390.5	C1C[C@H](NC1)CNC(=O)C2=CC=C(C=C2)C3=CN=C4N3N=C(C=C4)NCC5CC5	IC50 ~ 100000 nM	Poor binder
T15776	Pyruvate dehydrogenase kinase 1	BWX5H0	4-{5-[(Z)-(2-Imino-4-Oxo-1,3-Thiazolidin-5-Ylidene)methyl]furan-2-Yl}benzenesulfonamide	Investigative	137349062	C14H11N3O4S2	349.4	C1=CC(=CC=C1C2=CC=C(O2)/C=C\\3/C(=O)NC(=N)S3)S(=O)(=O)N	IC50 = 67000 nM	Poor binder
T15776	Pyruvate dehydrogenase kinase 1	BWY3P1	4-[6-[(3,4-Dichlorophenyl)methylamino]imidazo[1,2-b]pyridazin-3-yl]-N-[[(2S)-pyrrolidin-2-yl]methyl]benzamide	Investigative	49864850	C25H24Cl2N6O	495.4	C1C[C@H](NC1)CNC(=O)C2=CC=C(C=C2)C3=CN=C4N3N=C(C=C4)NCC5=CC(=C(C=C5)Cl)Cl	IC50 ~ 100000 nM	Poor binder