TTD_Target_ID	Target_Name	TTD_Drug_ID	Drug_Name	Drug_Highest_Status	Drug_PubchemID	Molecular_Formula	Molecular_Weight	Canonical_SMILES	Activity	Binder_Type
T15855	Dipeptidyl peptidase 8	D02EYG	Linagliptin	Approved	10096344	C25H28N8O2	472.5	CC#CCN1C2=C(N=C1N3CCC[C@H](C3)N)N(C(=O)N(C2=O)CC4=NC5=CC=CC=C5C(=N4)C)C	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	D0NJ5H	Alogliptin	Approved	11450633	C18H21N5O2	339.4	CN1C(=O)C=C(N(C1=O)CC2=CC=CC=C2C#N)N3CCC[C@H](C3)N	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	D0U2JP	Sitagliptin	Approved	4369359	C16H15F6N5O	407.31	C1CN2C(=NN=C2C(F)(F)F)CN1C(=O)C[C@@H](CC3=CC(=C(C=C3F)F)F)N	IC50 ~ 50000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	D0M3XR	MK-3102	Phase 3	46209133	C17H20F2N4O3S	398.4	CS(=O)(=O)N1C=C2CN(CC2=N1)[C@@H]3C[C@@H]([C@H](OC3)C4=C(C=CC(=C4)F)F)N	IC50 ~ 67000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	D04MAZ	Pyrimidine derivative 33	Patented	71731606	C23H24ClN5O2	437.9	CC#CCN1C(=CC(=O)N(C1=O)CC2=NC3=C(C=CC(=C3)Cl)C=C2)N4CCC[C@H](C4)N	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	D0SH7G	US8470836, 6	Patented	44126288	C22H23F5N6O3	514.4	C1CC([C@@H](N(C1=O)C[C@H](CC(=O)N2CCC3=C(C2)N=C(N=C3C(F)(F)F)C4=CC=NC=C4)N)O)(F)F	IC50 ~ 127000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	D0Q4YP	TAK-100	Discontinued in Phase 1	53326686	C22H32N2O3	372.5	CCC1=C(C(=C(C(=N1)CC(C)(C)C)CN)C2=CC=C(C=C2)C)CC(=O)O.O	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	B02HGP	(R)-3-Amino-1-((S)-8-methyl-2-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[1,5-a]pyrazin-7(8H)-yl)-4-(2,4,5-trifluorophenyl)butan-1-one	Investigative	44444353	C17H17F6N5O	421.34	C[C@H]1C2=NC(=NN2CCN1C(=O)C[C@@H](CC3=CC(=C(C=C3F)F)F)N)C(F)(F)F	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	B03NWM	(R)-3-Amino-4-(2-chloro-4,5-difluorophenyl)-1-(3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)butan-1-one	Investigative	44431206	C16H15ClF5N5O	423.77	C1CN2C(=NN=C2C(F)(F)F)CN1C(=O)C[C@@H](CC3=CC(=C(C=C3Cl)F)F)N	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	B04ZSR	(3R)-4-[(3R)-3-Amino-4-(2,4,5-trifluorophenyl)butanoyl]-1-tert-butyl-3-methyl-1,4-diazepan-2-one	Investigative	10318743	C20H28F3N3O2	399.4	C[C@@H]1C(=O)N(CCCN1C(=O)C[C@@H](CC2=CC(=C(C=C2F)F)F)N)C(C)(C)C	IC50 = 55000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	B05HAY	CID 53312239	Investigative	53312239	C21H24N6O2	392.5	CN1C2=NC(=CC(=C2N(C1=O)CC3=CC=CC=C3C#N)N4CCC[C@H](C4)N)CO	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	B05ITZ	N-[4-[(2S,3S)-3-Amino-4-[(3S)-3-fluoropyrrolidin-1-yl]-4-oxobutan-2-yl]phenyl]acetamide;2,2,2-trifluoroacetic acid	Investigative	49797350	C18H23F4N3O4	421.4	C[C@@H](C1=CC=C(C=C1)NC(=O)C)[C@@H](C(=O)N2CC[C@@H](C2)F)N.C(=O)(C(F)(F)F)O	IC50 = 82000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	B05VRP	(2R,3R)-7-Fluoro-3-(2,4,5-trifluorophenyl)-1,2,3,4-tetrahydropyrido[1,2-a]benzimidazol-2-amine;2,2,2-trifluoroacetic acid	Investigative	49797627	C19H14F7N3O2	449.3	C1[C@@H]([C@H](CN2C1=NC3=C2C=CC(=C3)F)N)C4=CC(=C(C=C4F)F)F.C(=O)(C(F)(F)F)O	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	B07WZD	N-[4-[4-[(2S,3S)-3-Amino-4-[(3S)-3-fluoropyrrolidin-1-yl]-4-oxobutan-2-yl]phenyl]phenyl]methanesulfonamide;2,2,2-trifluoroacetic acid	Investigative	49797092	C23H27F4N3O5S	533.5	C[C@@H](C1=CC=C(C=C1)C2=CC=C(C=C2)NS(=O)(=O)C)[C@@H](C(=O)N3CC[C@@H](C3)F)N.C(=O)(C(F)(F)F)O	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	B09NLJ	(3R)-3-Amino-1-{2-cyclopropyl-4H,5H,6H,7H-pyrido[3,4-d][1,3]oxazol-5-yl}-4-(2,5-difluorophenyl)butan-1-one	Investigative	23645945	C19H21F2N3O2	361.4	C1CC1C2=NC3=C(O2)CCN(C3)C(=O)C[C@@H](CC4=C(C=CC(=C4)F)F)N	IC50 = 51000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	B09OXH	2-((2-(3-(R)-Aminopiperidin-1-yl)-5-bromo-6-oxopyrimidin-1(6H)-yl)methyl)-4-fluorobenzonitrile	Investigative	11373129	C17H17BrFN5O	406.3	C1C[C@H](CN(C1)C2=NC=C(C(=O)N2CC3=C(C=CC(=C3)F)C#N)Br)N	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	B0AWM2	(2R,3R)-6,8-Difluoro-3-(2,4,5-trifluorophenyl)-1,2,3,4-tetrahydropyrido[1,2-a]benzimidazol-2-amine;2,2,2-trifluoroacetic acid	Investigative	49797642	C19H13F8N3O2	467.3	C1[C@@H]([C@H](CN2C1=NC3=C2C=C(C=C3F)F)N)C4=CC(=C(C=C4F)F)F.C(=O)(C(F)(F)F)O	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	B0BV3Q	(S)-2-(1-Hydroxy-2-methylpropan-2-ylamino)-1-(2-(5-methyl-1,2,4-oxadiazole-3-carbonyl)pyrrolidin-1-yl)ethanone	Investigative	44432858	C14H22N4O4	310.35	CC1=NC(=NO1)C(=O)[C@@H]2CCCN2C(=O)CNC(C)(C)CO	IC50 = 67300 nM	Poor binder
T15855	Dipeptidyl peptidase 8	B0DKU3	(3R,4R)-1-(3-Methyl-[1,2,4]triazolo[4,3-b]pyridazin-6-yl)-4-(2,4,5-trifluorophenyl)piperidin-3-amine;2,2,2-trifluoroacetic acid	Investigative	23661718	C19H18F6N6O2	476.4	CC1=NN=C2N1N=C(C=C2)N3CC[C@@H]([C@H](C3)N)C4=CC(=C(C=C4F)F)F.C(=O)(C(F)(F)F)O	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	B0DT7K	(2R,3S,5R)-5-(9-Methyl-4,7,8,12-tetrazatricyclo[6.4.0.02,6]dodeca-1,6,9,11-tetraen-4-yl)-2-(2,4,5-trifluorophenyl)oxan-3-amine	Investigative	127050761	C20H20F3N5O	403.4	CC1=CC=NC2=C3CN(CC3=NN12)[C@@H]4C[C@@H]([C@H](OC4)C5=CC(=C(C=C5F)F)F)N	IC50 = 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	B0FSW7	(2S,3S)-3-Amino-4-[(3S)-3-fluoropyrrolidin-1-yl]-2-(4-imidazo[1,2-a]pyridin-6-ylphenyl)-N,N-dimethyl-4-oxobutanamide;2,2,2-trifluoroacetic acid	Investigative	11584650	C25H27F4N5O4	537.5	CN(C)C(=O)[C@@H](C1=CC=C(C=C1)C2=CN3C=CN=C3C=C2)[C@@H](C(=O)N4CC[C@@H](C4)F)N.C(=O)(C(F)(F)F)O	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	B0HWB9	2-[[3-Methyl-2-oxo-7-(piperidin-4-ylamino)imidazo[4,5-b]pyridin-1-yl]methyl]benzonitrile	Investigative	118712516	C20H22N6O	362.4	CN1C2=NC=CC(=C2N(C1=O)CC3=CC=CC=C3C#N)NC4CCNCC4	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	B0J6OQ	(2S,3S)-3-Amino-2-[4-(4-fluorophenyl)phenyl]-N,N-dimethyl-4-oxo-4-piperidin-1-ylbutanamide;2,2,2-trifluoroacetic acid	Investigative	49796994	C25H29F4N3O4	511.5	CN(C)C(=O)[C@@H](C1=CC=C(C=C1)C2=CC=C(C=C2)F)[C@@H](C(=O)N3CCCCC3)N.C(=O)(C(F)(F)F)O	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	B0JN3R	N-[4-[(1R)-1-Amino-2-(2,5-difluorophenyl)ethyl]cyclohexyl]-N-(4,4,4-trifluorobutyl)acetamide	Investigative	53326713	C20H27F5N2O	406.4	CC(=O)N(CCCC(F)(F)F)C1CCC(CC1)[C@@H](CC2=C(C=CC(=C2)F)F)N	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	B0KJ5P	2-[[7-[(3R)-3-Aminopiperidin-1-yl]-3-methyl-2-oxoimidazo[4,5-b]pyridin-1-yl]methyl]benzonitrile	Investigative	53311227	C20H22N6O	362.4	CN1C2=NC=CC(=C2N(C1=O)CC3=CC=CC=C3C#N)N4CCC[C@H](C4)N	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	B0M5SP	(3R)-3-Amino-1-[(6S)-6-methyl-3-(trifluoromethyl)-6,8-dihydro-5H-[1,2,4]triazolo[4,3-a]pyrazin-7-yl]-4-(2,4,5-trifluorophenyl)butan-1-one;hydrochloride	Investigative	45263683	C17H18ClF6N5O	457.8	C[C@H]1CN2C(=NN=C2C(F)(F)F)CN1C(=O)C[C@@H](CC3=CC(=C(C=C3F)F)F)N.Cl	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	B0OZ6X	2-[2-(3-(r)-Aminopiperidin-1-yl)-5-ethynyl-6-oxo-6h-pyrimidin-1-ylmethyl]benzonitrile	Investigative	11416338	C19H19N5O	333.4	C#CC1=CN=C(N(C1=O)CC2=CC=CC=C2C#N)N3CCC[C@H](C3)N	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	B0P9NA	(3R,4R)-1-(2-Cyclopropyl-3-methylimidazo[4,5-b]pyridin-5-yl)-4-(2,4,5-trifluorophenyl)piperidin-3-amine;2,2,2-trifluoroacetic acid	Investigative	49797245	C23H23F6N5O2	515.5	CN1C(=NC2=C1N=C(C=C2)N3CC[C@@H]([C@H](C3)N)C4=CC(=C(C=C4F)F)F)C5CC5.C(=O)(C(F)(F)F)O	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	B0R5AG	(2R,3S,5R)-2-(2,5-Difluorophenyl)-5-(11-methyl-1,4,8,12-tetrazatricyclo[7.3.0.02,6]dodeca-2(6),7,9,11-tetraen-4-yl)oxan-3-amine	Investigative	127052289	C20H21F2N5O	385.4	CC1=NN2C3=C(CN(C3)[C@@H]4C[C@@H]([C@H](OC4)C5=C(C=CC(=C5)F)F)N)C=NC2=C1	IC50 = 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	B0RN4O	(3S)-1-[(2S,3S)-2-Amino-3-(4-fluorophenyl)-1-oxobutanyl]-3-fluoropyrrolidine trifluoroacetic acid salt	Investigative	49797053	C16H19F5N2O3	382.33	C[C@@H](C1=CC=C(C=C1)F)[C@@H](C(=O)N2CC[C@@H](C2)F)N.C(=O)(C(F)(F)F)O	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	B0RP1O	(2S,3S)-3-Amino-4-(3,3-difluoroazetidin-1-yl)-2-[4-(4-fluorophenyl)phenyl]-N,N-dimethyl-4-oxobutanamide;2,2,2-trifluoroacetic acid	Investigative	49797012	C23H23F6N3O4	519.4	CN(C)C(=O)[C@@H](C1=CC=C(C=C1)C2=CC=C(C=C2)F)[C@@H](C(=O)N3CC(C3)(F)F)N.C(=O)(C(F)(F)F)O	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	B0RX3J	(2S,4S)-4-(4-Chlorobenzylamino)-2-amino-1-(piperidin-1-yl)pentan-1-one	Investigative	16046127	C17H26ClN3O	323.9	C[C@@H](C[C@@H](C(=O)N1CCCCC1)N)NCC2=CC=C(C=C2)Cl	IC50 = 148000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	B0UQK5	(2S,3S)-2-Amino-1-[(3S)-3-fluoropyrrolidin-1-yl]-3-[4-(2-methylphenyl)phenyl]butan-1-one;2,2,2-trifluoroacetic acid	Investigative	49797086	C23H26F4N2O3	454.5	CC1=CC=CC=C1C2=CC=C(C=C2)[C@H](C)[C@@H](C(=O)N3CC[C@@H](C3)F)N.C(=O)(C(F)(F)F)O	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	B0V4GL	(2S,3S)-3-Amino-4-[(3S)-3-fluoropyrrolidin-1-yl]-N,N-dimethyl-2-[4-(2-methyl-[1,2,4]triazolo[1,5-a]pyridin-6-yl)phenyl]-4-oxobutanamide;2,2,2-trifluoroacetic acid	Investigative	11628195	C25H28F4N6O4	552.5	CC1=NN2C=C(C=CC2=N1)C3=CC=C(C=C3)[C@@H]([C@@H](C(=O)N4CC[C@@H](C4)F)N)C(=O)N(C)C.C(=O)(C(F)(F)F)O	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	B0VUR5	5-[4-[(2S,3S)-3-Amino-4-[(3S)-3-fluoropyrrolidin-1-yl]-4-oxobutan-2-yl]phenyl]-1,4-dimethylpyridin-2-one;2,2,2-trifluoroacetic acid	Investigative	49797128	C23H27F4N3O4	485.5	CC1=CC(=O)N(C=C1C2=CC=C(C=C2)[C@H](C)[C@@H](C(=O)N3CC[C@@H](C3)F)N)C.C(=O)(C(F)(F)F)O	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	B0Y9DQ	(R)-3-Amino-4-(2-fluorophenyl)-1-(3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)butan-1-one	Investigative	44431164	C16H17F4N5O	371.33	C1CN2C(=NN=C2C(F)(F)F)CN1C(=O)C[C@@H](CC3=CC=CC=C3F)N	IC50 = 75000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	B0YFZ2	1-((2S,4S)-2-(5-Tert-butyl-1,2,4-oxadiazole-3-carbonyl)-4-fluoropyrrolidin-1-yl)-2-(1-hydroxy-2-methylpropan-2-ylamino)ethanone	Investigative	44432859	C17H27FN4O4	370.4	CC(C)(C)C1=NC(=NO1)C(=O)[C@@H]2C[C@@H](CN2C(=O)CNC(C)(C)CO)F	IC50 = 69900 nM	Poor binder
T15855	Dipeptidyl peptidase 8	B0Z4NF	5-[4-[(2S,3S)-3-Amino-4-[(3S)-3-fluoropyrrolidin-1-yl]-4-oxobutan-2-yl]phenyl]-1-(cyclopropylmethyl)pyridin-2-one;2,2,2-trifluoroacetic acid	Investigative	49797127	C25H29F4N3O4	511.5	C[C@@H](C1=CC=C(C=C1)C2=CN(C(=O)C=C2)CC3CC3)[C@@H](C(=O)N4CC[C@@H](C4)F)N.C(=O)(C(F)(F)F)O	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	B10BFT	[3-Benzyl-5-(2-chlorophenyl)benzimidazol-4-yl]methanamine	Investigative	11551987	C21H18ClN3	347.8	C1=CC=C(C=C1)CN2C=NC3=C2C(=C(C=C3)C4=CC=CC=C4Cl)CN	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	B12BGJ	(2R,3S,5R)-2-(2-Chloro-5-fluorophenyl)-5-(4,6-dihydro-1H-pyrrolo[3,4-c]pyrazol-5-yl)oxan-3-amine	Investigative	73349220	C16H18ClFN4O	336.79	C1[C@H](CO[C@@H]([C@H]1N)C2=C(C=CC(=C2)F)Cl)N3CC4=C(C3)NN=C4	IC50 = 50000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	B13FAL	4-[(3R,5S,6R)-5-Amino-6-(2,4,5-trifluorophenyl)oxan-3-yl]-9-methyl-4,7,8,12-tetrazatricyclo[6.4.0.02,6]dodeca-1,6,9-trien-11-one	Investigative	137225025	C20H20F3N5O2	419.4	CC1=CC(=O)NC2=C3CN(CC3=NN12)[C@@H]4C[C@@H]([C@H](OC4)C5=CC(=C(C=C5F)F)F)N	IC50 = 92000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	B14KHA	(2S)-1-[(2S)-2-Amino-3-pyridin-2-ylpropanoyl]pyrrolidine-2-carbonitrile	Investigative	76336484	C13H16N4O	244.29	C1C[C@H](N(C1)C(=O)[C@H](CC2=CC=CC=N2)N)C#N	IC50 = 125100 nM	Poor binder
T15855	Dipeptidyl peptidase 8	B16DLO	2-[[2-[(3R)-3-Aminopiperidin-1-yl]-4,5-dimethyl-6-oxopyrimidin-1-yl]methyl]benzonitrile	Investigative	11348315	C19H23N5O	337.4	CC1=C(N=C(N(C1=O)CC2=CC=CC=C2C#N)N3CCC[C@H](C3)N)C	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	B16QZU	(2S,3S)-3-Amino-2-[4-(4-fluorophenyl)phenyl]-N,N-dimethyl-4-morpholin-4-yl-4-oxobutanamide;2,2,2-trifluoroacetic acid	Investigative	49797006	C24H27F4N3O5	513.5	CN(C)C(=O)[C@@H](C1=CC=C(C=C1)C2=CC=C(C=C2)F)[C@@H](C(=O)N3CCOCC3)N.C(=O)(C(F)(F)F)O	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	B18IJR	(2R,3R,5S)-2-(2,5-Difluorophenyl)-5-(4,6-dihydro-1H-pyrrolo[3,4-c]pyrazol-5-yl)oxan-3-amine	Investigative	72188903	C16H18F2N4O	320.34	C1[C@@H](CO[C@@H]([C@@H]1N)C2=C(C=CC(=C2)F)F)N3CC4=C(C3)NN=C4	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	B1B6OU	(S)-1-((2S,4R)-4-(2-(Isoindolin-2-yl)-2-oxoethyl)-5-oxopyrrolidine-2-carbonyl)pyrrolidine-2-carbonitrile	Investigative	46916388	C20H22N4O3	366.4	C1C[C@H](N(C1)C(=O)[C@@H]2C[C@@H](C(=O)N2)CC(=O)N3CC4=CC=CC=C4C3)C#N	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	B1FN5T	1-Pentanone, 2-amino-3-methyl-1-(1-piperidinyl)-, (2S,3S)-	Investigative	10821833	C11H22N2O	198.31	CC[C@H](C)[C@@H](C(=O)N1CCCCC1)N	IC50 = 76000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	B1G6EF	(3R)-3-Amino-1-[(8R)-8-[cyclopropyl(hydroxy)methyl]-2-(trifluoromethyl)-6,8-dihydro-5H-[1,2,4]triazolo[1,5-a]pyrazin-7-yl]-4-(2,4,5-trifluorophenyl)butan-1-one	Investigative	44444379	C20H21F6N5O2	477.4	C1CC1C([C@H]2C3=NC(=NN3CCN2C(=O)C[C@@H](CC4=CC(=C(C=C4F)F)F)N)C(F)(F)F)O	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	B1HQR8	4-[4-[(2S,3S)-3-Amino-4-[(3S)-3-fluoropyrrolidin-1-yl]-4-oxobutan-2-yl]phenyl]benzoic acid;2,2,2-trifluoroacetic acid	Investigative	49797082	C23H24F4N2O5	484.4	C[C@@H](C1=CC=C(C=C1)C2=CC=C(C=C2)C(=O)O)[C@@H](C(=O)N3CC[C@@H](C3)F)N.C(=O)(C(F)(F)F)O	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	B1K9VQ	(2S,3S)-3-Amino-4-[(3S)-3-fluoropyrrolidin-1-yl]-N,N-dimethyl-2-[4-(8-methyl-[1,2,4]triazolo[1,5-a]pyridin-6-yl)phenyl]-4-oxobutanamide;2,2,2-trifluoroacetic acid	Investigative	11526865	C25H28F4N6O4	552.5	CC1=CC(=CN2C1=NC=N2)C3=CC=C(C=C3)[C@@H]([C@@H](C(=O)N4CC[C@@H](C4)F)N)C(=O)N(C)C.C(=O)(C(F)(F)F)O	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	B1M7LE	(3R,4R)-1-Pyrido[2,3-b]pyrazin-3-yl-4-(2,4,5-trifluorophenyl)piperidin-3-amine;2,2,2-trifluoroacetic acid	Investigative	49797240	C20H17F6N5O2	473.4	C1CN(C[C@@H]([C@H]1C2=CC(=C(C=C2F)F)F)N)C3=CN=C4C=CC=NC4=N3.C(=O)(C(F)(F)F)O	IC50 = 66000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	B1O7FB	(2S,3S)-3-Amino-N-ethyl-2-[4-(4-fluorophenyl)phenyl]-4-[(3S)-3-fluoropyrrolidin-1-yl]-4-oxobutanamide;2,2,2-trifluoroacetic acid	Investigative	49797028	C24H26F5N3O4	515.5	CCNC(=O)[C@@H](C1=CC=C(C=C1)C2=CC=C(C=C2)F)[C@@H](C(=O)N3CC[C@@H](C3)F)N.C(=O)(C(F)(F)F)O	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	B1OWR7	(R)-3-Amino-1-(3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)-4-(2-(trifluoromethyl)phenyl)butan-1-one	Investigative	44431188	C17H17F6N5O	421.34	C1CN2C(=NN=C2C(F)(F)F)CN1C(=O)C[C@@H](CC3=CC=CC=C3C(F)(F)F)N	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	B1QJ5Z	6-[(3R)-3-Aminopiperidin-1-yl]-3-[(6-bromoquinolin-2-yl)methyl]-1-but-2-ynylpyrimidine-2,4-dione	Investigative	71731476	C23H24BrN5O2	482.4	CC#CCN1C(=CC(=O)N(C1=O)CC2=NC3=C(C=C2)C=C(C=C3)Br)N4CCC[C@H](C4)N	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	B1S9AZ	6-[(3R)-3-Aminopiperidin-1-yl]-1-but-2-ynyl-3-[(6-chloroquinolin-2-yl)methyl]pyrimidine-2,4-dione	Investigative	71731477	C23H24ClN5O2	437.9	CC#CCN1C(=CC(=O)N(C1=O)CC2=NC3=C(C=C2)C=C(C=C3)Cl)N4CCC[C@H](C4)N	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	B1SG4T	Chembl4213950	Investigative	145965136	C17H18N6O3	354.4	C1CN(CCN1)C2=CC(=O)N3C(=CC=N3)N2CC4=CC=CC=C4[N+](=O)[O-]	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	B1XA3I	(2S,3S)-2-Amino-1-(pyrrolidin-1-yl)-3-{3-[4-(trifluoromethyl)phenyl]-1,2,4-oxadiazol-5-yl}butan-1-one	Investigative	23645695	C17H19F3N4O2	368.35	C[C@H](C1=NC(=NO1)C2=CC=C(C=C2)C(F)(F)F)[C@@H](C(=O)N3CCCC3)N	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	B1XK5P	(R)-1-((R)-8-((1H-1,2,4-Triazol-1-yl)methyl)-2-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[1,5-a]pyrazin-7(8H)-yl)-3-amino-4-(2,4,5-trifluorophenyl)butan-1-one	Investigative	44444391	C19H18F6N8O	488.4	C1CN2C(=NC(=N2)C(F)(F)F)[C@H](N1C(=O)C[C@@H](CC3=CC(=C(C=C3F)F)F)N)CN4C=NC=N4	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	B1YQ9O	(R)-3-Amino-4-(2-chlorophenyl)-1-(3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)butan-1-one	Investigative	44431199	C16H17ClF3N5O	387.79	C1CN2C(=NN=C2C(F)(F)F)CN1C(=O)C[C@@H](CC3=CC=CC=C3Cl)N	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	B1YZ3X	(1S,2R,5R)-2-(2,5-Difluorophenyl)-5-(4,7,8,12-tetrazatricyclo[6.4.0.02,6]dodeca-1,6,9,11-tetraen-4-yl)cyclohexan-1-amine	Investigative	127052590	C20H21F2N5	369.4	C1C[C@@H]([C@H](C[C@@H]1N2CC3=C4N=CC=CN4N=C3C2)N)C5=C(C=CC(=C5)F)F	IC50 = 65000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	B20ICK	5-[4-[(2S,3S)-3-Amino-4-[(3S)-3-fluoropyrrolidin-1-yl]-4-oxobutan-2-yl]phenyl]-4-(hydroxymethyl)-1-methylpyridin-2-one;2,2,2-trifluoroacetic acid	Investigative	49797110	C23H27F4N3O5	501.5	C[C@@H](C1=CC=C(C=C1)C2=CN(C(=O)C=C2CO)C)[C@@H](C(=O)N3CC[C@@H](C3)F)N.C(=O)(C(F)(F)F)O	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	B20OJE	2,2,2-Trifluoroacetic acid;(3R,4R)-1-[6-(trifluoromethyl)pyridin-2-yl]-4-(2,4,5-trifluorophenyl)piperidin-3-amine	Investigative	49797227	C19H16F9N3O2	489.3	C1CN(C[C@@H]([C@H]1C2=CC(=C(C=C2F)F)F)N)C3=CC=CC(=N3)C(F)(F)F.C(=O)(C(F)(F)F)O	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	B21XNZ	trans-N-(4-((R)-1-Amino-2-(2,5-difluorophenyl)ethyl)cyclohexyl)-N-ethylacetamide	Investigative	53320181	C18H26F2N2O	324.4	CCN(C1CCC(CC1)[C@@H](CC2=C(C=CC(=C2)F)F)N)C(=O)C	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	B28JTM	(2S,4S)-1-{(2S,4S)-4-[2-(5-Chloro-1,3-dihydroisoindol-2-yl)-2-oxoethyl]-5-oxopyrrolidine-2-carbonyl}-4-fluoropyrrolidine-2-carbonitrile	Investigative	46916435	C20H20ClFN4O3	418.8	C1[C@@H](CN([C@@H]1C#N)C(=O)[C@@H]2C[C@H](C(=O)N2)CC(=O)N3CC4=C(C3)C=C(C=C4)Cl)F	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	B29JLM	(2S,3S)-2-Amino-3-[3-(2,4-dichlorophenyl)-1,2,4-oxadiazol-5-yl]-1-pyrrolidin-1-ylbutan-1-one;2,2,2-trifluoroacetic acid	Investigative	49797191	C18H19Cl2F3N4O4	483.3	C[C@H](C1=NC(=NO1)C2=C(C=C(C=C2)Cl)Cl)[C@@H](C(=O)N3CCCC3)N.C(=O)(C(F)(F)F)O	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	B2BP1T	5-[4-[(2S,3S)-3-Amino-4-[(3S)-3-fluoropyrrolidin-1-yl]-4-oxobutan-2-yl]phenyl]-3-chloro-4-fluoro-1-methylpyridin-2-one;2,2,2-trifluoroacetic acid	Investigative	49797119	C22H23ClF5N3O4	523.9	C[C@@H](C1=CC=C(C=C1)C2=CN(C(=O)C(=C2F)Cl)C)[C@@H](C(=O)N3CC[C@@H](C3)F)N.C(=O)(C(F)(F)F)O	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	B2CZ9O	(2R,3S,5R)-5-(1-Cyclopropylsulfonyl-4,6-dihydropyrrolo[3,4-c]pyrazol-5-yl)-2-(2,5-difluorophenyl)oxan-3-amine	Investigative	46209246	C19H22F2N4O3S	424.5	C1CC1S(=O)(=O)N2C3=C(CN(C3)[C@@H]4C[C@@H]([C@H](OC4)C5=C(C=CC(=C5)F)F)N)C=N2	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	B2DF8Z	(R)-3-Amino-4-(3,4-dichlorophenyl)-1-(3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)butan-1-one	Investigative	44431203	C16H16Cl2F3N5O	422.2	C1CN2C(=NN=C2C(F)(F)F)CN1C(=O)C[C@@H](CC3=CC(=C(C=C3)Cl)Cl)N	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	B2DW5B	2-[2-(3-(R)-Aminopiperidin-1-yl)-5-furan-3-yl-4-methyl-6-oxo-6H-pyrimidin-1-ylmethyl]benzonitrile	Investigative	11165177	C22H23N5O2	389.4	CC1=C(C(=O)N(C(=N1)N2CCC[C@H](C2)N)CC3=CC=CC=C3C#N)C4=COC=C4	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	B2EIL4	3-(4-((R)-1-Amino-2-(2,5-difluorophenyl)ethyl)piperidin-1-yl)cyclohexanecarboxylic acid	Investigative	53318866	C20H28F2N2O2	366.4	C1CC(CC(C1)N2CCC(CC2)[C@@H](CC3=C(C=CC(=C3)F)F)N)C(=O)O	IC50 = 72000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	B2F9CA	alpha-Amino acid pyrrolidide 29	Investigative	23645705	C17H21FN4O4S	396.4	C[C@H](C1=NC(=NO1)C2=C(C=C(C=C2)S(=O)(=O)C)F)[C@@H](C(=O)N3CCCC3)N	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	B2GOI5	N-[4-[(1R)-1-Amino-2-(2,5-difluorophenyl)ethyl]cyclohexyl]-N-methylthiadiazole-4-carboxamide	Investigative	53320178	C18H22F2N4OS	380.5	CN(C1CCC(CC1)[C@@H](CC2=C(C=CC(=C2)F)F)N)C(=O)C3=CSN=N3	IC50 = 70000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	B2GP8T	(3R)-3-Amino-1-(2-cyclopropyl-1,4-dimethyl-6,7-dihydro-1H-imidazo[4,5-c]pyridin-5(4H)-yl)-4-(2,4,5-trifluorophenyl)butan-1-one	Investigative	44443736	C21H25F3N4O	406.4	CC1C2=C(CCN1C(=O)C[C@@H](CC3=CC(=C(C=C3F)F)F)N)N(C(=N2)C4CC4)C	IC50 = 65000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	B2JE7O	(2S,3S)-2-Amino-1-((S)-3-fluoropyrrolidin-1-yl)-3-(4-(pyridin-4-yl)phenyl)butan-1-one	Investigative	23645622	C19H22FN3O	327.4	C[C@@H](C1=CC=C(C=C1)C2=CC=NC=C2)[C@@H](C(=O)N3CC[C@@H](C3)F)N	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	B2K3JS	(2S,3S)-2-((1r,4S)-4-([1,2,4]Triazolo[1,5-a]pyridin-5-yl)cyclohexyl)-3-amino-4-(3,3-difluoropyrrolidin-1-yl)-N,N-dimethyl-4-oxobutanamide	Investigative	11518007	C22H30F2N6O2	448.5	CN(C)C(=O)[C@@H](C1CCC(CC1)C2=CC=CC3=NC=NN32)[C@@H](C(=O)N4CCC(C4)(F)F)N	IC50 = 95000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	B2K9RS	Chembl4207996	Investigative	145977953	C19H23N5O	337.4	CC1=CC=C(C=C1)CN2C3=CC=NN3C(=O)C=C2N4CCC[C@H](C4)N	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	B2LBR3	(2S,3R)-2-Amino-1-(4,6-dihydro-1H-pyrrolo[3,4-c]pyrazol-5-yl)-3-methylpentan-1-one;2,2,2-trifluoroacetic acid	Investigative	127045827	C13H19F3N4O3	336.31	CC[C@@H](C)[C@@H](C(=O)N1CC2=C(C1)NN=C2)N.C(=O)(C(F)(F)F)O	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	B2M8CF	(2s)-1-({(2s,4s)-4-[2-[4-(4-Chlorophenyl)-3,6-dihydropyridin-1(2h)-yl]-2-oxoethyl]-5-oxopyrrolidin-2-yl}carbonyl)pyrrolidine-2-carbonitrile	Investigative	46916345	C23H25ClN4O3	440.9	C1C[C@H](N(C1)C(=O)[C@@H]2C[C@H](C(=O)N2)CC(=O)N3CCC(=CC3)C4=CC=C(C=C4)Cl)C#N	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	B2MZ1W	(R)-3-Amino-1-(3-(difluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)-4-(2,4,5-trifluorophenyl)butan-1-one	Investigative	44431219	C16H16F5N5O	389.32	C1CN2C(=NN=C2C(F)F)CN1C(=O)C[C@@H](CC3=CC(=C(C=C3F)F)F)N	IC50 = 86000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	B2NE7J	(2S,4S)-1-(2-((1,1-Dimethyl-3-oxo-3-(1-pyrrolidinyl)propyl)amino)acetyl)-4-fluoro-2-pyrrolidinecarbonitrile	Investigative	44201003	C16H25FN4O2	324.39	CC(C)(CC(=O)N1CCCC1)NCC(=O)N2C[C@H](C[C@H]2C#N)F	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	B2P5LC	(2S)-2,6-Diamino-1-(3-hydroxypyrrolidin-1-yl)hexan-1-one	Investigative	11310450	C10H21N3O2	215.29	C1CN(CC1O)C(=O)[C@H](CCCCN)N	IC50 = 139000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	B2PT7E	7-[(3R)-3-Aminopiperidin-1-yl]-1-[(2-chlorophenyl)methyl]-3-methylimidazo[4,5-b]pyridin-2-one	Investigative	53311223	C19H22ClN5O	371.9	CN1C2=NC=CC(=C2N(C1=O)CC3=CC=CC=C3Cl)N4CCC[C@H](C4)N	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	B2QCV9	5-[4-[(2S,3S)-3-Amino-4-[(3S)-3-fluoropyrrolidin-1-yl]-4-oxobutan-2-yl]phenyl]-1,6-dimethylpyridin-2-one;2,2,2-trifluoroacetic acid	Investigative	49797112	C23H27F4N3O4	485.5	CC1=C(C=CC(=O)N1C)C2=CC=C(C=C2)[C@H](C)[C@@H](C(=O)N3CC[C@@H](C3)F)N.C(=O)(C(F)(F)F)O	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	B2TVX7	2-[2-(3-(R)-Aminopiperidin-1-yl)-6-oxo-5-((E)-2-pyridin-3-ylvinyl)-6H-pyrimidin-1-ylmethyl]benzonitrile	Investigative	11361944	C24H24N6O	412.5	C1C[C@H](CN(C1)C2=NC=C(C(=O)N2CC3=CC=CC=C3C#N)/C=C/C4=CN=CC=C4)N	IC50 = 84000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	B2U1YG	(3-Methyl-5-phenylbenzimidazol-4-yl)methanamine	Investigative	11514208	C15H15N3	237.3	CN1C=NC2=C1C(=C(C=C2)C3=CC=CC=C3)CN	IC50 = 63000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	B2VLQ4	2-[[2-(3-Aminopiperidin-1-yl)-8-methoxy-4-oxoquinazolin-3-yl]methyl]benzonitrile	Investigative	11153488	C22H23N5O2	389.4	COC1=CC=CC2=C1N=C(N(C2=O)CC3=CC=CC=C3C#N)N4CCCC(C4)N	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	B2YIT4	(R)-3-Amino-4-(2,5-difluoro-phenyl)-1-[3-(4-fluoro-benzyl)-2-trifluoromethyl-1,4,6,7-tetrahydro-imidazo[4,5-c]pyridin-5-yl]-butan-1-one	Investigative	44443715	C24H22F6N4O	496.4	C1CN(CC2=C1N=C(N2CC3=CC=C(C=C3)F)C(F)(F)F)C(=O)C[C@@H](CC4=C(C=CC(=C4)F)F)N	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	B2YK3M	N-[3-[4-[(2S,3S)-3-Amino-4-[(3S)-3-fluoropyrrolidin-1-yl]-4-oxobutan-2-yl]phenyl]phenyl]-1,1,1-trifluoromethanesulfonamide;2,2,2-trifluoroacetic acid	Investigative	49797075	C23H24F7N3O5S	587.5	C[C@@H](C1=CC=C(C=C1)C2=CC(=CC=C2)NS(=O)(=O)C(F)(F)F)[C@@H](C(=O)N3CC[C@@H](C3)F)N.C(=O)(C(F)(F)F)O	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	B31BTC	(2R,3S,5R)-5-[11-(Trifluoromethyl)-4,7,8,12-tetrazatricyclo[6.4.0.02,6]dodeca-1,6,9,11-tetraen-4-yl]-2-(2,4,5-trifluorophenyl)oxan-3-amine	Investigative	127050760	C20H17F6N5O	457.4	C1[C@H](CO[C@@H]([C@H]1N)C2=CC(=C(C=C2F)F)F)N3CC4=C5N=C(C=CN5N=C4C3)C(F)(F)F	IC50 = 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	B32RLA	Unii-625uxd6cji	Investigative	11278798	C17H19N5O2	325.4	C1C[C@H](CN(C1)C2=CC(=O)NC(=O)N2CC3=CC=CC=C3C#N)N	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	B32ZGH	5-[4-[(2S,3S)-3-Amino-4-(3-fluoroazetidin-1-yl)-4-oxobutan-2-yl]phenyl]-1-methylpyridin-2-one;2,2,2-trifluoroacetic acid	Investigative	49797108	C21H23F4N3O4	457.4	C[C@@H](C1=CC=C(C=C1)C2=CN(C(=O)C=C2)C)[C@@H](C(=O)N3CC(C3)F)N.C(=O)(C(F)(F)F)O	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	B34XWR	3-[[7-[(3R)-3-Aminopiperidin-1-yl]-3-methyl-2-oxoimidazo[4,5-b]pyridin-1-yl]methyl]benzonitrile	Investigative	53311142	C20H22N6O	362.4	CN1C2=NC=CC(=C2N(C1=O)CC3=CC(=CC=C3)C#N)N4CCC[C@H](C4)N	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	B36ZLH	2-[[6-[(3R)-3-Amino-3-methylpiperidin-1-yl]-3-methyl-2,4-dioxopyrimidin-1-yl]methyl]-4-fluorobenzonitrile	Investigative	11440163	C19H22FN5O2	371.4	C[C@]1(CCCN(C1)C2=CC(=O)N(C(=O)N2CC3=C(C=CC(=C3)F)C#N)C)N	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	B38SRY	US9051329, Example 5	Investigative	71203758	C17H21N7O2	355.4	CC#CCN1C2=C(N=C3N(C(=O)CN3C2=O)C)N=C1N4CCC[C@H](C4)N	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	B39DFE	Chembl4215849	Investigative	145973710	C19H20N6O	348.4	C1C[C@H](CN(C1)C2=CC(=O)N3C(=CC=N3)N2CC4=CC=CC=C4C#N)N	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	B3AS4R	(2S,3S)-3-Amino-4-[(3S)-3-fluoropyrrolidin-1-yl]-N,N-dimethyl-4-oxo-2-(4-pyrazolo[1,5-a]pyrimidin-5-ylphenyl)butanamide;2,2,2-trifluoroacetic acid	Investigative	11591936	C24H26F4N6O4	538.5	CN(C)C(=O)[C@@H](C1=CC=C(C=C1)C2=NC3=CC=NN3C=C2)[C@@H](C(=O)N4CC[C@@H](C4)F)N.C(=O)(C(F)(F)F)O	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	B3BIF6	(S)-2-Amino-3-(4-hydroxyphenyl)-1-(pyrrolidin-1-yl)propan-1-one	Investigative	11817181	C13H18N2O2	234.29	C1CCN(C1)C(=O)[C@H](CC2=CC=C(C=C2)O)N	IC50 = 95000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	B3C0AY	(2S,3S)-3-Amino-2-[4-(4-fluorophenyl)phenyl]-4-[(3S)-3-fluoropyrrolidin-1-yl]-4-oxobutanoic acid;2,2,2-trifluoroacetic acid	Investigative	49796990	C22H21F5N2O5	488.4	C1CN(C[C@H]1F)C(=O)[C@H]([C@H](C2=CC=C(C=C2)C3=CC=C(C=C3)F)C(=O)O)N.C(=O)(C(F)(F)F)O	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	B3FTC1	Diphenyl 1-((2S,3S)-2-amino-3-methylpentanoyl)pyrrolidin-2-ylphosphonate	Investigative	10341846	C22H29N2O4P	416.4	CC[C@H](C)[C@@H](C(=O)N1CCCC1P(=O)(OC2=CC=CC=C2)OC3=CC=CC=C3)N	IC50 = 71000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	B3GC9X	(2S,3S)-2-Amino-1-[(3S)-3-fluoropyrrolidin-1-yl]-3-phenylbutan-1-one;2,2,2-trifluoroacetic acid	Investigative	49797058	C16H20F4N2O3	364.33	C[C@@H](C1=CC=CC=C1)[C@@H](C(=O)N2CC[C@@H](C2)F)N.C(=O)(C(F)(F)F)O	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	B3HXC4	(R)-3-Amino-4-(2,5-difluorophenyl)-1-(3-(hydroxymethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)butan-1-one	Investigative	44431216	C16H19F2N5O2	351.35	C1CN2C(=NN=C2CO)CN1C(=O)C[C@@H](CC3=C(C=CC(=C3)F)F)N	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	B3KG1J	(2S,3S)-3-Amino-2-[4-[(2,4-difluorophenyl)sulfonylamino]cyclohexyl]-4-[(3S)-3-fluoropyrrolidin-1-yl]-N,N-dimethyl-4-oxobutanamide;hydrochloride	Investigative	49797354	C22H32ClF3N4O4S	541	CN(C)C(=O)[C@@H](C1CCC(CC1)NS(=O)(=O)C2=C(C=C(C=C2)F)F)[C@@H](C(=O)N3CC[C@@H](C3)F)N.Cl	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	B3KX5B	2-[(3R)-3-Aminopiperidino]-3-(2-cyanobenzyl)-6-fluoroquinazoline-4(3H)-one	Investigative	9799867	C21H20FN5O	377.4	C1C[C@H](CN(C1)C2=NC3=C(C=C(C=C3)F)C(=O)N2CC4=CC=CC=C4C#N)N	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	B3LEO0	(3R,4R)-1-Pyrazino[2,3-b]pyrazin-3-yl-4-(2,4,5-trifluorophenyl)piperidin-3-amine;2,2,2-trifluoroacetic acid	Investigative	49797242	C19H16F6N6O2	474.4	C1CN(C[C@@H]([C@H]1C2=CC(=C(C=C2F)F)F)N)C3=NC4=NC=CN=C4N=C3.C(=O)(C(F)(F)F)O	IC50 = 54000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	B3OJ9A	(R)-3-Amino-1-(2-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[1,5-a]pyrazin-7(8H)-yl)-4-(2,4,5-trifluorophenyl)butan-1-one	Investigative	9953181	C16H15F6N5O	407.31	C1CN2C(=NC(=N2)C(F)(F)F)CN1C(=O)C[C@@H](CC3=CC(=C(C=C3F)F)F)N	IC50 = 62000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	B3P0VM	(2S,3S)-2-Amino-3-[3-(2-chlorophenyl)-1,2,4-oxadiazol-5-yl]-1-(pyrrolidin-1-yl)butan-1-one	Investigative	23645691	C16H19ClN4O2	334.8	C[C@H](C1=NC(=NO1)C2=CC=CC=C2Cl)[C@@H](C(=O)N3CCCC3)N	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	B3RA9E	2,2,2-Trifluoroacetic acid;(2R,3R)-6,7,8-trifluoro-3-(2,4,5-trifluorophenyl)-1,2,3,4-tetrahydropyrido[1,2-a]benzimidazol-2-amine	Investigative	49797604	C19H12F9N3O2	485.3	C1[C@@H]([C@H](CN2C1=NC3=C(C(=C(C=C32)F)F)F)N)C4=CC(=C(C=C4F)F)F.C(=O)(C(F)(F)F)O	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	B3TEZ7	6-[(3R)-3-Aminopiperidin-1-yl]-1-[(2-chloro-5-fluorophenyl)methyl]-3-methylpyrimidine-2,4-dione	Investigative	11303089	C17H20ClFN4O2	366.8	CN1C(=O)C=C(N(C1=O)CC2=C(C=CC(=C2)F)Cl)N3CCC[C@H](C3)N	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	B3VR6Z	(2S,3S)-2-Amino-3-phenyl-1-(1,3-thiazolidin-3-yl)butan-1-one	Investigative	23645582	C13H18N2OS	250.36	C[C@@H](C1=CC=CC=C1)[C@@H](C(=O)N2CCSC2)N	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	B3VYO1	(2R,3R)-8-Fluoro-3-(2,4,5-trifluorophenyl)-1,2,3,4-tetrahydropyrido[1,2-a]benzimidazol-2-amine;2,2,2-trifluoroacetic acid	Investigative	49797596	C19H14F7N3O2	449.3	C1[C@@H]([C@H](CN2C1=NC3=C2C=C(C=C3)F)N)C4=CC(=C(C=C4F)F)F.C(=O)(C(F)(F)F)O	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	B3WV0Q	5-[4-[(2S,3S)-3-Amino-4-oxo-4-(1,3-thiazolidin-3-yl)butan-2-yl]phenyl]-1-methylpyridin-2-one;2,2,2-trifluoroacetic acid	Investigative	49797107	C21H24F3N3O4S	471.5	C[C@@H](C1=CC=C(C=C1)C2=CN(C(=O)C=C2)C)[C@@H](C(=O)N3CCSC3)N.C(=O)(C(F)(F)F)O	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	B3XG5Y	(2R,3S,5R)-2-(2,5-Difluorophenyl)-5-(3-propan-2-ylsulfonyl-4,6-dihydro-1H-pyrrolo[3,4-c]pyrazol-5-yl)oxan-3-amine	Investigative	127035753	C19H24F2N4O3S	426.5	CC(C)S(=O)(=O)C1=NNC2=C1CN(C2)[C@@H]3C[C@@H]([C@H](OC3)C4=C(C=CC(=C4)F)F)N	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	B3ZRL2	(2S,3S)-3-Amino-4-(3,3-difluoropyrrolidin-1-yl)-N,N-dimethyl-4-oxo-2-[4-([1,2,4]triazolo[1,5-a]pyridin-6-yl)phenyl]butanamide;hydrochloride	Investigative	11576569	C22H25ClF2N6O2	478.9	CN(C)C(=O)[C@@H](C1=CC=C(C=C1)C2=CN3C(=NC=N3)C=C2)[C@@H](C(=O)N4CCC(C4)(F)F)N.Cl	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	B40GUH	CID 53311141	Investigative	53311141	C20H21ClN6O	396.9	CN1C2=NC=CC(=C2N(C1=O)CC3=C(C=C(C=C3)Cl)C#N)N4CCC[C@H](C4)N	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	B40WAX	CID 53311071	Investigative	53311071	C24H24N6O	412.5	CN1C2=NC=CC(=C2N(C1=O)CC3=C(C4=CC=CC=C4C=C3)C#N)N5CCC[C@H](C5)N	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	B41BNM	(3R)-3-Amino-1-(2-benzoyldiazepan-1-yl)-4-(2,4,5-trifluorophenyl)butan-1-one;hydrochloride	Investigative	16739330	C22H25ClF3N3O2	455.9	C1CCN(N(CC1)C(=O)C2=CC=CC=C2)C(=O)C[C@@H](CC3=CC(=C(C=C3F)F)F)N.Cl	IC50 = 89120 nM	Poor binder
T15855	Dipeptidyl peptidase 8	B45EFX	(1S,2R,5R)-5-(11-Methyl-4,7,8,12-tetrazatricyclo[6.4.0.02,6]dodeca-1,6,9,11-tetraen-4-yl)-2-(2,4,5-trifluorophenyl)cyclohexan-1-amine	Investigative	127051639	C21H22F3N5	401.4	CC1=NC2=C3CN(CC3=NN2C=C1)[C@@H]4CC[C@@H]([C@H](C4)N)C5=CC(=C(C=C5F)F)F	IC50 = 79000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	B45OBY	trans-N-(4-((R)-1-Amino-2-(2,5-difluorophenyl)ethyl)cyclohexyl)-N-ethylmethanesulfonamide	Investigative	53321487	C17H26F2N2O2S	360.5	CCN(C1CCC(CC1)[C@@H](CC2=C(C=CC(=C2)F)F)N)S(=O)(=O)C	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	B46LRO	(2S)-1-({(2S,4S)-4-[2-[4-(4-Fluorophenyl)piperazin-1-yl]-2-oxoethyl]-5-oxopyrrolidin-2-yl}carbonyl)pyrrolidine-2-carbonitrile	Investigative	46916343	C22H26FN5O3	427.5	C1C[C@H](N(C1)C(=O)[C@@H]2C[C@H](C(=O)N2)CC(=O)N3CCN(CC3)C4=CC=C(C=C4)F)C#N	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	B46PGE	(3R)-3-Amino-4-(2,5-difluorophenyl)-1-[1-methyl-3-(trifluoromethyl)-1H,4H,5H,6H,7H-pyrazolo[4,3-c]pyridin-5-yl]butan-1-one	Investigative	23645919	C18H19F5N4O	402.4	CN1C2=C(CN(CC2)C(=O)C[C@@H](CC3=C(C=CC(=C3)F)F)N)C(=N1)C(F)(F)F	IC50 = 68000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	B47WRK	(R)-3-Amino-1-(3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)-4-(3-(trifluoromethyl)phenyl)butan-1-one	Investigative	44431191	C17H17F6N5O	421.34	C1CN2C(=NN=C2C(F)(F)F)CN1C(=O)C[C@@H](CC3=CC(=CC=C3)C(F)(F)F)N	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	B47ZBC	(2s,3s)-3-Amino-4-[(3s)-3-Fluoropyrrolidin-1-Yl]-N,N-Dimethyl-4-Oxo-2-(trans-4-[1,2,4]triazolo[1,5-A]pyridin-5-Ylcyclohexyl)butanamide	Investigative	11495704	C22H31FN6O2	430.5	CN(C)C(=O)[C@@H](C1CCC(CC1)C2=CC=CC3=NC=NN32)[C@@H](C(=O)N4CC[C@@H](C4)F)N	IC50 = 53000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	B48UHG	Ethyl 2-[5-[4-[(2S,3S)-3-amino-4-[(3S)-3-fluoropyrrolidin-1-yl]-4-oxobutan-2-yl]phenyl]-2-oxopyridin-1-yl]acetate;2,2,2-trifluoroacetic acid	Investigative	49797122	C25H29F4N3O6	543.5	CCOC(=O)CN1C=C(C=CC1=O)C2=CC=C(C=C2)[C@H](C)[C@@H](C(=O)N3CC[C@@H](C3)F)N.C(=O)(C(F)(F)F)O	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	B4DQU6	Methyl (2S,3S)-3-amino-2-[4-(4-fluorophenyl)phenyl]-4-[(3S)-3-fluoropyrrolidin-1-yl]-4-oxobutanoate;2,2,2-trifluoroacetic acid	Investigative	49796982	C23H23F5N2O5	502.4	COC(=O)[C@@H](C1=CC=C(C=C1)C2=CC=C(C=C2)F)[C@@H](C(=O)N3CC[C@@H](C3)F)N.C(=O)(C(F)(F)F)O	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	B4DTJ0	5-(Aminomethyl)-N-cyclopropyl-4-(4-fluorophenyl)-6-methylpicolinamide	Investigative	51356957	C17H18FN3O	299.34	CC1=C(C(=CC(=N1)C(=O)NC2CC2)C3=CC=C(C=C3)F)CN	Ki = 106000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	B4E9DC	(2S,3S)-2-(4-Acetamidophenyl)-3-amino-4-[(3S)-3-fluoropyrrolidin-1-yl]-N,N-dimethyl-4-oxobutanamide;2,2,2-trifluoroacetic acid	Investigative	49797349	C20H26F4N4O5	478.4	CC(=O)NC1=CC=C(C=C1)[C@@H]([C@@H](C(=O)N2CC[C@@H](C2)F)N)C(=O)N(C)C.C(=O)(C(F)(F)F)O	IC50 = 60000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	B4G7MW	(2R,3S,5R)-2-(2,4-Difluorophenyl)-5-(4,6-dihydro-1H-pyrrolo[3,4-c]pyrazol-5-yl)oxan-3-amine	Investigative	73350799	C16H18F2N4O	320.34	C1[C@H](CO[C@@H]([C@H]1N)C2=C(C=C(C=C2)F)F)N3CC4=C(C3)NN=C4	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	B4GUY6	(3R,4R)-1-Pyridin-3-yl-4-(2,4,5-trifluorophenyl)piperidin-3-amine;2,2,2-trifluoroacetic acid	Investigative	49797225	C18H17F6N3O2	421.3	C1CN(C[C@@H]([C@H]1C2=CC(=C(C=C2F)F)F)N)C3=CN=CC=C3.C(=O)(C(F)(F)F)O	IC50 = 54000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	B4I9KH	N-[5-[(3R,5S,6R)-5-Amino-6-(2,5-difluorophenyl)oxan-3-yl]-4,6-dihydro-1H-pyrrolo[3,4-c]pyrazol-3-yl]ethanesulfonamide	Investigative	127035742	C18H23F2N5O3S	427.5	CCS(=O)(=O)NC1=NNC2=C1CN(C2)[C@@H]3C[C@@H]([C@H](OC3)C4=C(C=CC(=C4)F)F)N	IC50 = 89000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	B4JER3	cis-(R)-2-(2,5-Difluorophenyl)-1-(4-(piperidin-1-yl)cyclohexyl)ethanamine	Investigative	53321497	C19H28F2N2	322.4	C1CCN(CC1)C2CCC(CC2)[C@@H](CC3=C(C=CC(=C3)F)F)N	IC50 = 56000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	B4LA8P	2,2,2-Trifluoroacetic acid;(2R,3R)-7-(trifluoromethyl)-3-(2,4,5-trifluorophenyl)-1,2,3,4-tetrahydropyrido[1,2-a]benzimidazol-2-amine	Investigative	49797630	C20H14F9N3O2	499.3	C1[C@@H]([C@H](CN2C1=NC3=C2C=CC(=C3)C(F)(F)F)N)C4=CC(=C(C=C4F)F)F.C(=O)(C(F)(F)F)O	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	B4MH8I	2,2,2-Trifluoroacetic acid;(3R,4R)-1-[3-(trifluoromethyl)-[1,2,4]triazolo[4,3-b]pyridazin-6-yl]-4-(2,4,5-trifluorophenyl)piperidin-3-amine	Investigative	49797252	C19H15F9N6O2	530.3	C1CN(C[C@@H]([C@H]1C2=CC(=C(C=C2F)F)F)N)C3=NN4C(=NN=C4C(F)(F)F)C=C3.C(=O)(C(F)(F)F)O	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	B4N6ZF	(3R)-3-Amino-4-(2,5-difluorophenyl)-1-[3-(4-fluorophenyl)-1-methyl-1H,4H,5H,6H,7H-pyrazolo[4,3-c]pyridin-5-yl]butan-1-one	Investigative	23645929	C23H23F3N4O	428.4	CN1C2=C(CN(CC2)C(=O)C[C@@H](CC3=C(C=CC(=C3)F)F)N)C(=N1)C4=CC=C(C=C4)F	IC50 = 62000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	B4NG8J	(2R,3S,5R)-2-(2,5-Difluorophenyl)-5-(11-methyl-4,7,8,12-tetrazatricyclo[6.4.0.02,6]dodeca-1,6,9,11-tetraen-4-yl)oxan-3-amine	Investigative	127049204	C20H21F2N5O	385.4	CC1=NC2=C3CN(CC3=NN2C=C1)[C@@H]4C[C@@H]([C@H](OC4)C5=C(C=CC(=C5)F)F)N	IC50 = 59000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	B4QZL7	(2R,3S,5R)-5-(2-Cyclopropyl-5,5-dimethyl-7H-pyrrolo[3,4-d]pyrimidin-6-yl)-2-(2,5-difluorophenyl)oxan-3-amine	Investigative	73352283	C22H26F2N4O	400.5	CC1(C2=CN=C(N=C2CN1[C@@H]3C[C@@H]([C@H](OC3)C4=C(C=CC(=C4)F)F)N)C5CC5)C	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	B4RS3Z	2-({2-[(3R)-3-Aminopiperidin-1-yl]-6,7-dimethoxy-4-oxo-3,4-dihydroquinazolin-3-yl}methyl)benzonitrile	Investigative	16658105	C23H25N5O3	419.5	COC1=C(C=C2C(=C1)C(=O)N(C(=N2)N3CCC[C@H](C3)N)CC4=CC=CC=C4C#N)OC	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	B4U6AP	(2R,3R)-6-Fluoro-3-(2,4,5-trifluorophenyl)-1,2,3,4-tetrahydropyrido[1,2-a]benzimidazol-2-amine;2,2,2-trifluoroacetic acid	Investigative	49797653	C19H14F7N3O2	449.3	C1[C@@H]([C@H](CN2C1=NC3=C2C=CC=C3F)N)C4=CC(=C(C=C4F)F)F.C(=O)(C(F)(F)F)O	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	B4US5K	N-[4-[(1R)-1-Amino-2-(2,5-difluorophenyl)ethyl]cyclohexyl]-N,5-dimethyl-1H-pyrazole-4-sulfonamide	Investigative	53325446	C19H26F2N4O2S	412.5	CC1=C(C=NN1)S(=O)(=O)N(C)C2CCC(CC2)[C@@H](CC3=C(C=CC(=C3)F)F)N	IC50 = 71000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	B4UZI7	2,2,2-Trifluoroacetic acid;(3R,4R)-1-[3-(trifluoromethyl)pyridin-2-yl]-4-(2,4,5-trifluorophenyl)piperidin-3-amine	Investigative	49797230	C19H16F9N3O2	489.3	C1CN(C[C@@H]([C@H]1C2=CC(=C(C=C2F)F)F)N)C3=C(C=CC=N3)C(F)(F)F.C(=O)(C(F)(F)F)O	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	B4W3OE	(2S,3S)-2-Amino-3-[3-(2-chloro-4-methylsulfonylphenyl)-1,2,4-oxadiazol-5-yl]-1-[(3S)-3-fluoropyrrolidin-1-yl]-5-methylhexan-1-one;2,2,2-trifluoroacetic acid	Investigative	49797196	C22H27ClF4N4O6S	587	CC(C)C[C@H](C1=NC(=NO1)C2=C(C=C(C=C2)S(=O)(=O)C)Cl)[C@@H](C(=O)N3CC[C@@H](C3)F)N.C(=O)(C(F)(F)F)O	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	B4WF7G	(2S,3S)-2-Amino-1-(5-azidoisoindolin-2-yl)-3-methylpentan-1-one	Investigative	44560554	C14H19N5O	273.33	CC[C@H](C)[C@@H](C(=O)N1CC2=C(C1)C=C(C=C2)N=[N+]=[N-])N	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	B4X2WT	(2S,3S)-2-Amino-3-[3-(4-chlorophenyl)-1,2,4-oxadiazol-5-yl]-1-(pyrrolidin-1-yl)butan-1-one	Investigative	23645693	C16H19ClN4O2	334.8	C[C@H](C1=NC(=NO1)C2=CC=C(C=C2)Cl)[C@@H](C(=O)N3CCCC3)N	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	B4XLG5	(2S,3S)-2-Amino-1-[(3S)-3-fluoropyrrolidin-1-yl]-3-[4-[3-(2H-tetrazol-5-yl)phenyl]phenyl]butan-1-one;2,2,2-trifluoroacetic acid	Investigative	49797060	C23H24F4N6O3	508.5	C[C@@H](C1=CC=C(C=C1)C2=CC(=CC=C2)C3=NNN=N3)[C@@H](C(=O)N4CC[C@@H](C4)F)N.C(=O)(C(F)(F)F)O	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	B4Z2RF	N-[4-[5-[(2S,3S)-3-Amino-4-(3,3-difluoropyrrolidin-1-yl)-4-oxobutan-2-yl]-1,2,4-oxadiazol-3-yl]-3-chlorophenyl]methanesulfonamide;2,2,2-trifluoroacetic acid	Investigative	49797193	C19H21ClF5N5O6S	577.9	C[C@H](C1=NC(=NO1)C2=C(C=C(C=C2)NS(=O)(=O)C)Cl)[C@@H](C(=O)N3CCC(C3)(F)F)N.C(=O)(C(F)(F)F)O	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	B50ABY	(3R)-3-Amino-1-[(6R)-6-methyl-3-(trifluoromethyl)-6,8-dihydro-5H-[1,2,4]triazolo[4,3-a]pyrazin-7-yl]-4-(2,4,5-trifluorophenyl)butan-1-one;hydrochloride	Investigative	45266006	C17H18ClF6N5O	457.8	C[C@@H]1CN2C(=NN=C2C(F)(F)F)CN1C(=O)C[C@@H](CC3=CC(=C(C=C3F)F)F)N.Cl	IC50 = 75000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	B52SDG	(2S,3S)-3-Amino-4-[(3S)-3-fluoropyrrolidin-1-yl]-N,N-dimethyl-4-oxo-2-[4-[3-(tetrazol-1-yl)phenyl]phenyl]butanamide;2,2,2-trifluoroacetic acid	Investigative	49797014	C25H27F4N7O4	565.5	CN(C)C(=O)[C@@H](C1=CC=C(C=C1)C2=CC(=CC=C2)N3C=NN=N3)[C@@H](C(=O)N4CC[C@@H](C4)F)N.C(=O)(C(F)(F)F)O	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	B56PFV	(2R,3R)-7-Ethylsulfonyl-3-(2,4,5-trifluorophenyl)-1,2,3,4-tetrahydropyrido[1,2-a]benzimidazol-2-amine;2,2,2-trifluoroacetic acid	Investigative	49797612	C21H19F6N3O4S	523.5	CCS(=O)(=O)C1=CC2=C(C=C1)N3C[C@@H]([C@H](CC3=N2)C4=CC(=C(C=C4F)F)F)N.C(=O)(C(F)(F)F)O	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	B56VPF	(2S,3S)-2-Amino-3-[4-(4-fluorophenyl)phenyl]-1-[(3S)-3-fluoropyrrolidin-1-yl]butan-1-one	Investigative	9884543	C20H22F2N2O	344.4	C[C@@H](C1=CC=C(C=C1)C2=CC=C(C=C2)F)[C@@H](C(=O)N3CC[C@@H](C3)F)N	IC50 = 88000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	B57CZO	(2S,3S)-3-{3-[4-(Methylsulfonyl)phenyl]-1,2,4-oxadiazol-5-yl}-1-oxo-1-pyrrolidin-1-ylbutan-2-amine	Investigative	23645698	C17H22N4O4S	378.4	C[C@H](C1=NC(=NO1)C2=CC=C(C=C2)S(=O)(=O)C)[C@@H](C(=O)N3CCCC3)N	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	B57JVO	(2S,3S)-2-Amino-3-(2-fluorophenyl)-1-[(3S)-3-fluoropyrrolidin-1-yl]butan-1-one;2,2,2-trifluoroacetic acid	Investigative	49797059	C16H19F5N2O3	382.33	C[C@@H](C1=CC=CC=C1F)[C@@H](C(=O)N2CC[C@@H](C2)F)N.C(=O)(C(F)(F)F)O	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	B58LGR	(2S,4S)-4-[[(3R)-3-Amino-4-(2,4,5-trifluorophenyl)butanoyl]amino]-1-[(2S)-2-[[(1S)-1-carboxy-3-phenylpropyl]amino]butanoyl]pyrrolidine-2-carboxylic acid	Investigative	53354470	C29H35F3N4O6	592.6	CC[C@@H](C(=O)N1C[C@H](C[C@H]1C(=O)O)NC(=O)C[C@@H](CC2=CC(=C(C=C2F)F)F)N)N[C@@H](CCC3=CC=CC=C3)C(=O)O	IC50 = 69000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	B59DXB	(2S,3S)-3-Amino-2-(4''-fluorobiphenyl-4-yl)-4-((S)-3-fluoropyrrolidin-1-yl)-N,N-dimethyl-4-oxobutanamide	Investigative	10250452	C22H25F2N3O2	401.4	CN(C)C(=O)[C@@H](C1=CC=C(C=C1)C2=CC=C(C=C2)F)[C@@H](C(=O)N3CC[C@@H](C3)F)N	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	B5AFQ3	6-[(3R)-3-Aminopiperidin-1-yl]-1-[(2-bromophenyl)methyl]-3-methylpyrimidine-2,4-dione	Investigative	11234761	C17H21BrN4O2	393.3	CN1C(=O)C=C(N(C1=O)CC2=CC=CC=C2Br)N3CCC[C@H](C3)N	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	B5CFR9	N-[5-[[4-[(1R)-1-Amino-2-(2,5-difluorophenyl)ethyl]cyclohexyl]-methylsulfamoyl]-4-methyl-1,3-thiazol-2-yl]acetamide	Investigative	53326704	C21H28F2N4O3S2	486.6	CC1=C(SC(=N1)NC(=O)C)S(=O)(=O)N(C)C2CCC(CC2)[C@@H](CC3=C(C=CC(=C3)F)F)N	IC50 = 62000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	B5HGW3	(2R,3S,5R)-2-(2,5-Difluorophenyl)-5-(pyrrolo[3,4-c]pyrazol-5(1H,4H,6H)-yl)tetrahydro-2H-pyran-3-amine	Investigative	24769723	C16H18F2N4O	320.34	C1[C@H](CO[C@@H]([C@H]1N)C2=C(C=CC(=C2)F)F)N3CC4=C(C3)NN=C4	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	B5L6RD	2-[3-[2-[2-Cyano-(S)-pyrrolidin-1-yl]-2-oxoethylamino]-3-methyl-1-oxobutyl]-1,3-dihydroisoindole	Investigative	10383508	C20H26N4O2	354.4	CC(C)(CC(=O)N1CC2=CC=CC=C2C1)NCC(=O)N3CCC[C@H]3C#N	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	B5LR8J	DPP-4 ligand 3	Investigative	23647136	C16H16ClF4N5O	405.78	C1CN2C(=NN=C2C(F)(F)F)CN1C(=O)C[C@@H](CC3=C(C=CC(=C3)Cl)F)N	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	B5N7EQ	Trelagliptin	Investigative	15983988	C18H20FN5O2	357.4	CN1C(=O)C=C(N(C1=O)CC2=C(C=CC(=C2)F)C#N)N3CCC[C@H](C3)N	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	B5NA0M	N-[4-[(1R)-1-Amino-2-(2,5-difluorophenyl)ethyl]cyclohexyl]-N-ethyl-3,5-dimethyl-1,2-oxazole-4-sulfonamide	Investigative	53321486	C21H29F2N3O3S	441.5	CCN(C1CCC(CC1)[C@@H](CC2=C(C=CC(=C2)F)F)N)S(=O)(=O)C3=C(ON=C3C)C	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	B5SVJ0	(2S,3S)-3-Amino-4-(3-fluoroazetidin-1-yl)-N,N-dimethyl-4-oxo-2-[4-([1,2,4]triazolo[1,5-a]pyridin-6-yl)phenyl]butanamide;2,2,2-trifluoroacetic acid	Investigative	11540951	C23H24F4N6O4	524.5	CN(C)C(=O)[C@@H](C1=CC=C(C=C1)C2=CN3C(=NC=N3)C=C2)[C@@H](C(=O)N4CC(C4)F)N.C(=O)(C(F)(F)F)O	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	B5US6T	(2S)-1-[(2S)-4-[2-(1,3-Dihydroisoindol-2-yl)-2-oxoethyl]-5-oxopyrrolidine-2-carbonyl]pyrrolidine-2-carbonitrile	Investigative	52946866	C20H22N4O3	366.4	C1C[C@H](N(C1)C(=O)[C@@H]2CC(C(=O)N2)CC(=O)N3CC4=CC=CC=C4C3)C#N	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	B5VGF4	(2S,3S)-3-Amino-2-[4-(benzenesulfonamido)phenyl]-4-[(3S)-3-fluoropyrrolidin-1-yl]-N,N-dimethyl-4-oxobutanamide;2,2,2-trifluoroacetic acid	Investigative	49797344	C24H28F4N4O6S	576.6	CN(C)C(=O)[C@@H](C1=CC=C(C=C1)NS(=O)(=O)C2=CC=CC=C2)[C@@H](C(=O)N3CC[C@@H](C3)F)N.C(=O)(C(F)(F)F)O	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	B5VPI4	N-[4-[(1R)-1-Amino-2-(2,5-difluorophenyl)ethyl]cyclohexyl]-N,5-dimethyl-1,2-oxazole-4-sulfonamide	Investigative	53321485	C19H25F2N3O3S	413.5	CC1=C(C=NO1)S(=O)(=O)N(C)C2CCC(CC2)[C@@H](CC3=C(C=CC(=C3)F)F)N	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	B5Y9FD	5-Aminomethyl-4-(2,4-dichlorophenyl)-6-methyl-pyridine-2-carboxylic acid cyanomethyl-amide	Investigative	49837961	C16H14Cl2N4O	349.2	CC1=C(C(=CC(=N1)C(=O)NCC#N)C2=C(C=C(C=C2)Cl)Cl)CN	Ki = 66000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	B61OJB	trans-(R)-2-(2,5-Difluorophenyl)-1-(4-(3,3-difluoropyrrolidin-1-yl)cyclohexyl)ethanamine	Investigative	53321496	C18H24F4N2	344.4	C1CC(CCC1[C@@H](CC2=C(C=CC(=C2)F)F)N)N3CCC(C3)(F)F	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	B62ECO	(2S,3S)-2-Amino-3-(3-chlorophenyl)-1-[(3S)-3-fluoropyrrolidin-1-yl]butan-1-one;2,2,2-trifluoroacetic acid	Investigative	49797040	C16H19ClF4N2O3	398.78	C[C@@H](C1=CC(=CC=C1)Cl)[C@@H](C(=O)N2CC[C@@H](C2)F)N.C(=O)(C(F)(F)F)O	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	B62XNL	(2S)-1-[(2S,4S)-4-[2-(5,7-Dihydro-4H-thieno[2,3-c]pyridin-6-yl)-2-oxoethyl]-5-oxopyrrolidine-2-carbonyl]pyrrolidine-2-carbonitrile	Investigative	46938706	C19H22N4O3S	386.5	C1C[C@H](N(C1)C(=O)[C@@H]2C[C@H](C(=O)N2)CC(=O)N3CCC4=C(C3)SC=C4)C#N	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	B63GSY	(2S,3S)-2-Amino-3-methyl-1-(4-methylisoindolin-2-yl)pentan-1-one	Investigative	44560397	C15H22N2O	246.35	CC[C@H](C)[C@@H](C(=O)N1CC2=CC=CC(=C2C1)C)N	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	B64JCW	5-(Aminomethyl)-4-(2,4-difluorophenyl)-6-methyl-N-(5-methylisoxazol-3-yl)picolinamide	Investigative	51356959	C18H16F2N4O2	358.3	CC1=CC(=NO1)NC(=O)C2=NC(=C(C(=C2)C3=C(C=C(C=C3)F)F)CN)C	Ki = 179000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	B65QFW	5-[4-[(2S,3S)-3-Amino-4-[(3S)-3-fluoropyrrolidin-1-yl]-4-oxobutan-2-yl]phenyl]-4-methoxy-1-methylpyridin-2-one;2,2,2-trifluoroacetic acid	Investigative	49797118	C23H27F4N3O5	501.5	C[C@@H](C1=CC=C(C=C1)C2=CN(C(=O)C=C2OC)C)[C@@H](C(=O)N3CC[C@@H](C3)F)N.C(=O)(C(F)(F)F)O	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	B65YCI	(R)-2-(2,5-Difluorophenyl)-1-(1-(methylsulfonyl)piperidin-4-yl)ethanamine	Investigative	53324155	C14H20F2N2O2S	318.38	CS(=O)(=O)N1CCC(CC1)[C@@H](CC2=C(C=CC(=C2)F)F)N	IC50 = 95000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	B67QTG	(3R)-3-Amino-1-[8-(2,2,2-trifluoroethyl)-3-(trifluoromethyl)-6,8-dihydro-5H-[1,2,4]triazolo[4,3-a]pyrazin-7-yl]-4-(2,4,5-trifluorophenyl)butan-1-one;hydrochloride	Investigative	45263686	C18H17ClF9N5O	525.8	C1CN2C(=NN=C2C(F)(F)F)C(N1C(=O)C[C@@H](CC3=CC(=C(C=C3F)F)F)N)CC(F)(F)F.Cl	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	B68RTY	N-[4-[(1R)-1-Amino-2-(2,5-difluorophenyl)ethyl]cyclohexyl]-4-cyano-N-methylbenzenesulfonamide	Investigative	53317565	C22H25F2N3O2S	433.5	CN(C1CCC(CC1)[C@@H](CC2=C(C=CC(=C2)F)F)N)S(=O)(=O)C3=CC=C(C=C3)C#N	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	B69EXM	(2S,4R)-4-(4-Chlorobenzylamino)-2-amino-5-methyl-1-(piperidin-1-yl)heptan-1-one	Investigative	44415929	C20H32ClN3O	365.9	CCC(C)[C@@H](C[C@@H](C(=O)N1CCCCC1)N)NCC2=CC=C(C=C2)Cl	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	B6APY3	(2R,3R)-3-(3-(2,4-Dichlorophenyl)-1,2,4-oxadiazol-5-yl)-1-(2,4,5-trifluorophenyl)butan-2-amine	Investigative	44561154	C18H14Cl2F3N3O	416.2	C[C@@H](C1=NC(=NO1)C2=C(C=C(C=C2)Cl)Cl)[C@@H](CC3=CC(=C(C=C3F)F)F)N	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	B6CME5	6-[(3R)-3-Aminopiperidin-1-yl]-1-but-2-ynyl-3-[(6-fluoroquinolin-2-yl)methyl]pyrimidine-2,4-dione	Investigative	71731478	C23H24FN5O2	421.5	CC#CCN1C(=CC(=O)N(C1=O)CC2=NC3=C(C=C2)C=C(C=C3)F)N4CCC[C@H](C4)N	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	B6DO2S	2-[[7-[(3R)-3-Aminopiperidin-1-yl]-3-methyl-2-oxobenzimidazol-1-yl]methyl]benzonitrile	Investigative	56652661	C21H23N5O	361.4	CN1C2=C(C(=CC=C2)N3CCC[C@H](C3)N)N(C1=O)CC4=CC=CC=C4C#N	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	B6EPR5	(2S)-1-[(2S,4S)-5-Oxo-4-[2-oxo-2-[2-(trifluoromethyl)-6,8-dihydro-5H-imidazo[1,2-a]pyrazin-7-yl]ethyl]pyrrolidine-2-carbonyl]pyrrolidine-2-carbonitrile	Investigative	46916384	C19H21F3N6O3	438.4	C1C[C@H](N(C1)C(=O)[C@@H]2C[C@H](C(=O)N2)CC(=O)N3CCN4C=C(N=C4C3)C(F)(F)F)C#N	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	B6F4WY	Bis(4-acetamidophenyl) 1-(pyrrolidine-2-carbonyl)pyrrolidin-2-ylphosphonate	Investigative	10415172	C25H31N4O6P	514.5	CC(=O)NC1=CC=C(C=C1)OP(=O)(C2CCCN2C(=O)C3CCCN3)OC4=CC=C(C=C4)NC(=O)C	IC50 = 56000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	B6HGC1	(2s)-1-({(2s,4s)-4-[2-(1,3-Dihydro-2h-isoindol-2-yl)-2-oxoethyl]-5-oxopyrrolidin-2-yl}carbonyl)-4,4-difluoropyrrolidine-2-carbonitrile	Investigative	46917048	C20H20F2N4O3	402.4	C1[C@H](C(=O)N[C@@H]1C(=O)N2CC(C[C@H]2C#N)(F)F)CC(=O)N3CC4=CC=CC=C4C3	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	B6IGR3	N-[4-[(1R)-1-Amino-2-(2,5-difluorophenyl)ethyl]cyclohexyl]-N,3,5-trimethyl-1,2-oxazole-4-sulfonamide	Investigative	51346970	C20H27F2N3O3S	427.5	CC1=C(C(=NO1)C)S(=O)(=O)N(C)C2CCC(CC2)[C@@H](CC3=C(C=CC(=C3)F)F)N	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	B6ISN7	(2S,3S)-2-Amino-1-[(3S)-3-fluoropyrrolidin-1-yl]-3-[4-(2-methoxyphenyl)phenyl]butan-1-one;2,2,2-trifluoroacetic acid	Investigative	49797085	C23H26F4N2O4	470.5	C[C@@H](C1=CC=C(C=C1)C2=CC=CC=C2OC)[C@@H](C(=O)N3CC[C@@H](C3)F)N.C(=O)(C(F)(F)F)O	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	B6JK8S	2[2-(3-(R)-Aminopiperidin-1-yl)-5-bromo-4-methyl-6-oxo-6Hpyrimidin-1-ylmethyl]benzonitrile	Investigative	11418204	C18H20BrN5O	402.3	CC1=C(C(=O)N(C(=N1)N2CCC[C@H](C2)N)CC3=CC=CC=C3C#N)Br	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	B6L7QG	CID 44123747	Investigative	44123747	C22H25FN6O2	424.5	C[C@]1(CCCN(C1)C2=CC3=C(N2CC4=C(C=CC(=C4)F)C#N)C(=O)N(C(=O)N3C)C)N	IC50 ~ 50000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	B6M4CL	4-[[5-(Aminomethyl)-2-methyl-4-(4-methylphenyl)-6-(2-methylpropyl)pyridine-3-carbonyl]oxymethyl]benzoic acid;dihydrochloride	Investigative	69446993	C27H32Cl2N2O4	519.5	CC1=CC=C(C=C1)C2=C(C(=NC(=C2C(=O)OCC3=CC=C(C=C3)C(=O)O)C)CC(C)C)CN.Cl.Cl	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	B6R8UY	(2R,3R)-8-Methylsulfonyl-3-(2,4,5-trifluorophenyl)-1,2,3,4-tetrahydropyrido[1,2-a]benzimidazol-2-amine;2,2,2-trifluoroacetic acid	Investigative	49797631	C20H17F6N3O4S	509.4	CS(=O)(=O)C1=CC2=C(C=C1)N=C3N2C[C@@H]([C@H](C3)C4=CC(=C(C=C4F)F)F)N.C(=O)(C(F)(F)F)O	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	B6RS4Q	2-[[2-[(3R)-3-Aminopiperidin-1-yl]-6-oxopyrimidin-1-yl]methyl]benzonitrile	Investigative	11392716	C17H19N5O	309.4	C1C[C@H](CN(C1)C2=NC=CC(=O)N2CC3=CC=CC=C3C#N)N	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	B6TD4U	5-[4-[(2S,3S)-3-Amino-4-[(3S)-3-fluoropyrrolidin-1-yl]-4-oxobutan-2-yl]phenyl]-4-fluoro-1-methylpyridin-2-one;2,2,2-trifluoroacetic acid	Investigative	49797125	C22H24F5N3O4	489.4	C[C@@H](C1=CC=C(C=C1)C2=CN(C(=O)C=C2F)C)[C@@H](C(=O)N3CC[C@@H](C3)F)N.C(=O)(C(F)(F)F)O	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	B6VAC3	(2S,4S)-1-[(2S)-2-Amino-3-(4-nitrophenyl)propanoyl]-4-fluoropyrrolidine-2-carbonitrile	Investigative	72697359	C14H15FN4O3	306.29	C1[C@@H](CN([C@@H]1C#N)C(=O)[C@H](CC2=CC=C(C=C2)[N+](=O)[O-])N)F	IC50 ~ 58000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	B6YX3Z	N-[[(2S,3As,7aS)-1-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)butanoyl]-2,3,3a,4,5,6,7,7a-octahydroindol-2-yl]methyl]-1,1,1-trifluoromethanesulfonamide	Investigative	101879512	C20H25F6N3O3S	501.5	C1CC[C@H]2[C@@H](C1)C[C@H](N2C(=O)C[C@@H](CC3=CC(=C(C=C3F)F)F)N)CNS(=O)(=O)C(F)(F)F	IC50 = 56330 nM	Poor binder
T15855	Dipeptidyl peptidase 8	B70WEH	(2S,3S)-2-Amino-1-[(3S)-3-fluoropyrrolidin-1-yl]-3-[4-(trifluoromethyl)phenyl]butan-1-one;2,2,2-trifluoroacetic acid	Investigative	49797044	C17H19F7N2O3	432.33	C[C@@H](C1=CC=C(C=C1)C(F)(F)F)[C@@H](C(=O)N2CC[C@@H](C2)F)N.C(=O)(C(F)(F)F)O	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	B71PAI	(2S,3S)-2-Amino-3-[5-(2,4-dichlorophenyl)-1,2,4-oxadiazol-3-yl]-1-pyrrolidin-1-ylbutan-1-one;2,2,2-trifluoroacetic acid	Investigative	49797201	C18H19Cl2F3N4O4	483.3	C[C@H](C1=NOC(=N1)C2=C(C=C(C=C2)Cl)Cl)[C@@H](C(=O)N3CCCC3)N.C(=O)(C(F)(F)F)O	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	B72UBN	US9051329, Example 2	Investigative	71203783	C21H22N8O2	418.5	CN1C(=O)CN2C1=NC3=C(C2=O)N(C(=N3)N4CCC[C@H](C4)N)CC5=CC=CC=C5C#N	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	B75PXL	(2S,3S)-2-Amino-1-[(3S)-3-fluoropyrrolidin-1-yl]-3-[4-(1,3-thiazol-2-yl)phenyl]butan-1-one;2,2,2-trifluoroacetic acid	Investigative	49797067	C19H21F4N3O3S	447.4	C[C@@H](C1=CC=C(C=C1)C2=NC=CS2)[C@@H](C(=O)N3CC[C@@H](C3)F)N.C(=O)(C(F)(F)F)O	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	B76BRW	trans-4-(((4-((R)-1-Amino-2-(2,5-difluorophenyl)ethyl)cyclohexyl)(methyl)amino)methyl)benzonitrile	Investigative	53322821	C23H27F2N3	383.5	CN(CC1=CC=C(C=C1)C#N)C2CCC(CC2)[C@@H](CC3=C(C=CC(=C3)F)F)N	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	B76FAH	trans-N-(4-((R)-1-Amino-2-(2,5-difluorophenyl)ethyl)cyclohexyl)-N-benzylacetamide	Investigative	53318863	C23H28F2N2O	386.5	CC(=O)N(CC1=CC=CC=C1)C2CCC(CC2)[C@@H](CC3=C(C=CC(=C3)F)F)N	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	B78ELA	(3R)-4-[(3R)-3-Amino-4-(2,4,5-trifluorophenyl)butanoyl]-1-(2-hydroxyethyl)-3-methyl-1,4-diazepan-2-one	Investigative	23647119	C18H24F3N3O3	387.4	C[C@@H]1C(=O)N(CCCN1C(=O)C[C@@H](CC2=CC(=C(C=C2F)F)F)N)CCO	IC50 = 53000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	B79LVS	7-[(3R)-3-Aminopiperidin-1-yl]-1-[(2-cyanophenyl)methyl]-3-methyl-2-oxoimidazo[4,5-b]pyridine-5-carboxamide	Investigative	118712520	C21H23N7O2	405.5	CN1C2=C(C(=CC(=N2)C(=O)N)N3CCC[C@H](C3)N)N(C1=O)CC4=CC=CC=C4C#N	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	B7DV5T	(3R)-3-Amino-1-[8-ethyl-3-(trifluoromethyl)-6,8-dihydro-5H-[1,2,4]triazolo[4,3-a]pyrazin-7-yl]-4-(2,4,5-trifluorophenyl)butan-1-one;hydrochloride	Investigative	45265953	C18H20ClF6N5O	471.8	CCC1C2=NN=C(N2CCN1C(=O)C[C@@H](CC3=CC(=C(C=C3F)F)F)N)C(F)(F)F.Cl	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	B7GCH2	(R)-3-Amino-4-(2,5-difluorophenyl)-1-(3-ethyl-2-(trifluoromethyl)-6,7-dihydro-3H-imidazo[4,5-c]pyridin-5(4H)-yl)butan-1-one	Investigative	44443711	C19H21F5N4O	416.4	CCN1C2=C(CCN(C2)C(=O)C[C@@H](CC3=C(C=CC(=C3)F)F)N)N=C1C(F)(F)F	IC50 = 77000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	B7H4VB	2-[[7-[(3S)-3-Aminopiperidin-1-yl]-3-methyl-2-oxoimidazo[4,5-b]pyridin-1-yl]methyl]benzonitrile	Investigative	118712518	C20H22N6O	362.4	CN1C2=NC=CC(=C2N(C1=O)CC3=CC=CC=C3C#N)N4CCC[C@@H](C4)N	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	B7JV8T	2-(3,4-Difluorophenyl)-1,2,3,4-tetrahydroisoquinoline	Investigative	23646029	C15H13F2N	245.27	C1CN(CC2=CC=CC=C21)C3=CC(=C(C=C3)F)F	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	B7M2VT	alpha-Amino acid pyrrolidide 21	Investigative	23645699	C17H23N5O4S	393.5	C[C@H](C1=NC(=NO1)C2=CC=C(C=C2)NS(=O)(=O)C)[C@@H](C(=O)N3CCCC3)N	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	B7NOD4	(3R)-1-(4-(4-Fluorobenzyl)-1-methyl-2-(trifluoromethyl)-6,7-dihydro-1H-imidazo[4,5-c]pyridin-5(4H)-yl)-3-amino-4-(2,4,5-trifluorophenyl)butan-1-one	Investigative	10324641	C25H23F7N4O	528.5	CN1C2=C(C(N(CC2)C(=O)C[C@@H](CC3=CC(=C(C=C3F)F)F)N)CC4=CC=C(C=C4)F)N=C1C(F)(F)F	IC50 = 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	B7RWG9	6-[(3R)-3-Aminopiperidin-1-yl]-1-but-2-ynyl-3-[(6-methoxyquinolin-2-yl)methyl]pyrimidine-2,4-dione	Investigative	71731604	C24H27N5O3	433.5	CC#CCN1C(=CC(=O)N(C1=O)CC2=NC3=C(C=C2)C=C(C=C3)OC)N4CCC[C@H](C4)N	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	B7SQI1	2-[2-(3-(r)-Aminopiperidin-1-yl)-5-fluoro-6-oxo-6h-pyrimidin-1-ylmethyl]benzonitrile	Investigative	11151568	C17H18FN5O	327.36	C1C[C@H](CN(C1)C2=NC=C(C(=O)N2CC3=CC=CC=C3C#N)F)N	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	B7VOK6	(3R)-4-[(3R)-3-Amino-4-(2,4,5-trifluorophenyl)butanoyl]-3-(pyridin-2-ylmethyl)-1,4-diazepan-2-one	Investigative	23646451	C21H23F3N4O2	420.4	C1CNC(=O)[C@H](N(C1)C(=O)C[C@@H](CC2=CC(=C(C=C2F)F)F)N)CC3=CC=CC=N3	IC50 = 53000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	B7WOM8	3-[3-[4-[(2S,3S)-3-Amino-4-[(3S)-3-fluoropyrrolidin-1-yl]-4-oxobutan-2-yl]phenyl]phenyl]-4H-1,2,4-oxadiazol-5-one;2,2,2-trifluoroacetic acid	Investigative	135518358	C24H24F4N4O5	524.5	C[C@@H](C1=CC=C(C=C1)C2=CC(=CC=C2)C3=NOC(=O)N3)[C@@H](C(=O)N4CC[C@@H](C4)F)N.C(=O)(C(F)(F)F)O	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	B7Y9IF	(3R)-3-Amino-4-(2,5-difluorophenyl)-1-[3-(trifluoromethyl)-1H,4H,5H,6H,7H-pyrazolo[4,3-b]pyridin-4-yl]butan-1-one	Investigative	23645937	C17H17F5N4O	388.33	C1CC2=C(C(=NN2)C(F)(F)F)N(C1)C(=O)C[C@@H](CC3=C(C=CC(=C3)F)F)N	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	B7Z1KR	trans-N-(4-((R)-1-Amino-2-(2,5-difluorophenyl)ethyl)cyclohexyl)-N-methylpivalamide	Investigative	53326706	C20H30F2N2O	352.5	CC(C)(C)C(=O)N(C)C1CCC(CC1)[C@@H](CC2=C(C=CC(=C2)F)F)N	IC50 = 50000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	B80MYL	N-[4-[(1R)-1-Amino-2-(2,5-difluorophenyl)ethyl]cyclohexyl]-3,5-dimethyl-N-(4,4,4-trifluorobutyl)-1,2-oxazole-4-sulfonamide	Investigative	53325447	C23H30F5N3O3S	523.6	CC1=C(C(=NO1)C)S(=O)(=O)N(CCCC(F)(F)F)C2CCC(CC2)[C@@H](CC3=C(C=CC(=C3)F)F)N	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	B81BDG	2-[[2-(3-Aminopiperidin-1-yl)-8-chloro-4-oxoquinazolin-3-yl]methyl]benzonitrile	Investigative	11432169	C21H20ClN5O	393.9	C1CC(CN(C1)C2=NC3=C(C=CC=C3Cl)C(=O)N2CC4=CC=CC=C4C#N)N	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	B83NFQ	(2S,3S)-2-Amino-1-(pyrrolidin-1-yl)-3-{3-[2-(trifluoromethoxy)phenyl]-1,2,4-oxadiazol-5-yl}butan-1-one	Investigative	23645688	C17H19F3N4O3	384.35	C[C@H](C1=NC(=NO1)C2=CC=CC=C2OC(F)(F)F)[C@@H](C(=O)N3CCCC3)N	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	B86TRF	2-[2-(3-(R)-Aminopiperidin-1-yl)-6-oxo-5-phenyl-6H-pyrimidin-1-ylmethyl]benzonitrile	Investigative	11246131	C23H23N5O	385.5	C1C[C@H](CN(C1)C2=NC=C(C(=O)N2CC3=CC=CC=C3C#N)C4=CC=CC=C4)N	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	B87FLV	5-(Aminomethyl)-N-cyclopropyl-4-(2,4-difluorophenyl)-6-methylpicolinamide	Investigative	51356962	C17H17F2N3O	317.33	CC1=C(C(=CC(=N1)C(=O)NC2CC2)C3=C(C=C(C=C3)F)F)CN	Ki = 182000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	B87XOA	5-[4-[(2S,3S)-3-Amino-4-[(3S)-3-fluoropyrrolidin-1-yl]-4-oxobutan-2-yl]phenyl]-1H-pyridin-2-one;2,2,2-trifluoroacetic acid	Investigative	49797114	C21H23F4N3O4	457.4	C[C@@H](C1=CC=C(C=C1)C2=CNC(=O)C=C2)[C@@H](C(=O)N3CC[C@@H](C3)F)N.C(=O)(C(F)(F)F)O	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	B89OCN	(2s)-1-({(2s,4s)-4-[2-(5-Trifluoromethyl-1,3-dihydro-2h-isoindol-2-yl)-2-oxoethyl]-5-oxopyrrolidin-2-yl}carbonyl)pyrrolidine-2-carbonitrile	Investigative	46916433	C21H21F3N4O3	434.4	C1C[C@H](N(C1)C(=O)[C@@H]2C[C@H](C(=O)N2)CC(=O)N3CC4=C(C3)C=C(C=C4)C(F)(F)F)C#N	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	B89PFI	(3R)-3-Amino-4-(2,5-difluorophenyl)-1-[2-methyl-3-(1,1,2,2,2-pentafluoroethyl)-2H,4H,5H,6H,7H-pyrazolo[4,3-c]pyridin-5-yl]butan-1-one	Investigative	23645927	C19H19F7N4O	452.4	CN1C(=C2CN(CCC2=N1)C(=O)C[C@@H](CC3=C(C=CC(=C3)F)F)N)C(C(F)(F)F)(F)F	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	B8C1GN	(2S,3S)-3-Amino-4-(1,1-dioxo-1,3-thiazolidin-3-yl)-2-[4-(4-fluorophenyl)phenyl]-N,N-dimethyl-4-oxobutanamide;2,2,2-trifluoroacetic acid	Investigative	49797029	C23H25F4N3O6S	547.5	CN(C)C(=O)[C@@H](C1=CC=C(C=C1)C2=CC=C(C=C2)F)[C@@H](C(=O)N3CCS(=O)(=O)C3)N.C(=O)(C(F)(F)F)O	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	B8CHM9	2-({2-[(3R)-3-Aminopiperidin-1-yl]-6-fluoro-7-(morpholin-4-yl)-4-oxo-3,4-dihydroquinazolin-3-yl}methyl)benzonitrile	Investigative	23647314	C25H27FN6O2	462.5	C1C[C@H](CN(C1)C2=NC3=CC(=C(C=C3C(=O)N2CC4=CC=CC=C4C#N)F)N5CCOCC5)N	IC50 ~ 50000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	B8CN3T	(2S)-1-(2-{[4-(6-Fluoro-1,2,3,4-tetrahydroisoquinolin-2-yl)-2-methyl-4-oxobutan-2-yl]amino}acetyl)pyrrolidine-2-carbonitrile	Investigative	11545508	C21H27FN4O2	386.5	CC(C)(CC(=O)N1CCC2=C(C1)C=CC(=C2)F)NCC(=O)N3CCC[C@H]3C#N	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	B8GN5O	(3R)-3-Amino-1-[3-(trifluoromethyl)-8-[[2-(trifluoromethyl)phenyl]methyl]-6,8-dihydro-5H-[1,2,4]triazolo[4,3-a]pyrazin-7-yl]-4-(2,4,5-trifluorophenyl)butan-1-one;hydrochloride	Investigative	45263674	C24H21ClF9N5O	601.9	C1CN2C(=NN=C2C(F)(F)F)C(N1C(=O)C[C@@H](CC3=CC(=C(C=C3F)F)F)N)CC4=CC=CC=C4C(F)(F)F.Cl	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	B8H1NF	(3R)-4-[(3R)-3-Amino-4-(2,4,5-trifluorophenyl)butanoyl]-1-cyclopropyl-3-methyl-1,4-diazepan-2-one	Investigative	23647122	C19H24F3N3O2	383.4	C[C@@H]1C(=O)N(CCCN1C(=O)C[C@@H](CC2=CC(=C(C=C2F)F)F)N)C3CC3	IC50 = 58000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	B8IG1M	(2S,3S)-2-Amino-4-cyclopropyl-1-[(3S)-3-fluoropyrrolidin-1-yl]-3-[3-(4-methylsulfonylphenyl)-1,2,4-oxadiazol-5-yl]butan-1-one;2,2,2-trifluoroacetic acid	Investigative	49797198	C22H26F4N4O6S	550.5	CS(=O)(=O)C1=CC=C(C=C1)C2=NOC(=N2)[C@@H](CC3CC3)[C@@H](C(=O)N4CC[C@@H](C4)F)N.C(=O)(C(F)(F)F)O	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	B8IRZ9	(3R)-3-Amino-1-[8-prop-2-enyl-3-(trifluoromethyl)-6,8-dihydro-5H-[1,2,4]triazolo[4,3-a]pyrazin-7-yl]-4-(2,4,5-trifluorophenyl)butan-1-one;hydrochloride	Investigative	45263688	C19H20ClF6N5O	483.8	C=CCC1C2=NN=C(N2CCN1C(=O)C[C@@H](CC3=CC(=C(C=C3F)F)F)N)C(F)(F)F.Cl	IC50 = 72000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	B8KWG1	2-({2-[(3R)-3-Aminopiperidin-1-yl]-6,8-dichloro-4-oxo-3,4-dihydroquinazolin-3-yl}methyl)benzonitrile	Investigative	16658101	C21H19Cl2N5O	428.3	C1C[C@H](CN(C1)C2=NC3=C(C=C(C=C3Cl)Cl)C(=O)N2CC4=CC=CC=C4C#N)N	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	B8L0CX	1-[[(S)-2-Pyrrolidinyl]carbonyl]-2-pyrrolidinylphosphonic acid diphenyl ester	Investigative	10340933	C21H25N2O4P	400.4	C1C[C@H](NC1)C(=O)N2CCCC2P(=O)(OC3=CC=CC=C3)OC4=CC=CC=C4	IC50 = 71000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	B8LUM3	6-[(3R)-3-Aminopiperidin-1-yl]-3-(1H-benzimidazol-2-ylmethyl)-1-but-2-ynylpyrimidine-2,4-dione	Investigative	71731355	C21H24N6O2	392.5	CC#CCN1C(=CC(=O)N(C1=O)CC2=NC3=CC=CC=C3N2)N4CCC[C@H](C4)N	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	B8M7VO	6-[(3R)-3-Aminopiperidin-1-yl]-3-benzyl-1-but-2-ynylpyrimidine-2,4-dione	Investigative	71731241	C20H24N4O2	352.4	CC#CCN1C(=CC(=O)N(C1=O)CC2=CC=CC=C2)N3CCC[C@H](C3)N	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	B8OT2D	(2S,3S)-2-Amino-3-[4-[3-(5-cyclopropyl-1,2,4-oxadiazol-3-yl)phenyl]phenyl]-1-[(3S)-3-fluoropyrrolidin-1-yl]butan-1-one;2,2,2-trifluoroacetic acid	Investigative	49797064	C27H28F4N4O4	548.5	C[C@@H](C1=CC=C(C=C1)C2=CC(=CC=C2)C3=NOC(=N3)C4CC4)[C@@H](C(=O)N5CC[C@@H](C5)F)N.C(=O)(C(F)(F)F)O	IC50 = 55000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	B8PXB5	(2S,3S)-2-Amino-3-(4-bromophenyl)-1-((S)-3-fluoropyrrolidin-1-yl)butan-1-one	Investigative	10087948	C14H18BrFN2O	329.21	C[C@@H](C1=CC=C(C=C1)Br)[C@@H](C(=O)N2CC[C@@H](C2)F)N	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	B8R9GA	(2S,3S)-3-Amino-4-(3,3-difluoropyrrolidin-1-yl)-N,N-dimethyl-4-oxo-2-(4-pyrazolo[1,5-a]pyrimidin-5-ylphenyl)butanamide;2,2,2-trifluoroacetic acid	Investigative	11541314	C24H25F5N6O4	556.5	CN(C)C(=O)[C@@H](C1=CC=C(C=C1)C2=NC3=CC=NN3C=C2)[C@@H](C(=O)N4CCC(C4)(F)F)N.C(=O)(C(F)(F)F)O	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	B8S4DO	(2R,3S,5R)-5-(2-Cyclopentylsulfonyl-4,6-dihydropyrrolo[3,4-c]pyrazol-5-yl)-2-(2,5-difluorophenyl)oxan-3-amine	Investigative	46209244	C21H26F2N4O3S	452.5	C1CCC(C1)S(=O)(=O)N2C=C3CN(CC3=N2)[C@@H]4C[C@@H]([C@H](OC4)C5=C(C=CC(=C5)F)F)N	IC50 = 60000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	B8S9CW	5-[4-[(2S,3S)-3-Amino-4-[(3S)-3-fluoropyrrolidin-1-yl]-4-oxobutan-2-yl]phenyl]-6-fluoro-1-methylpyridin-2-one;2,2,2-trifluoroacetic acid	Investigative	49797111	C22H24F5N3O4	489.4	C[C@@H](C1=CC=C(C=C1)C2=C(N(C(=O)C=C2)C)F)[C@@H](C(=O)N3CC[C@@H](C3)F)N.C(=O)(C(F)(F)F)O	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	B8UP0B	2-[[6-[(3R)-3-Aminopiperidin-1-yl]-9-methyl-8-oxopurin-7-yl]methyl]benzonitrile	Investigative	56962798	C19H21N7O	363.4	CN1C2=C(C(=NC=N2)N3CCC[C@H](C3)N)N(C1=O)CC4=CC=CC=C4C#N	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	B8UX4E	(2S)-1-[(2S)-2-Amino-3-[4-(trifluoromethyl)phenyl]propanoyl]pyrrolidine-2-carbonitrile	Investigative	72697208	C15H16F3N3O	311.3	C1C[C@H](N(C1)C(=O)[C@H](CC2=CC=C(C=C2)C(F)(F)F)N)C#N	IC50 = 52120 nM	Poor binder
T15855	Dipeptidyl peptidase 8	B8W1MK	(1S,2R,5S)-2-(2,5-Difluorophenyl)-5-(4,7,8,12-tetrazatricyclo[6.4.0.02,6]dodeca-1,6,9,11-tetraen-4-yl)cyclohexan-1-amine	Investigative	24952087	C20H21F2N5	369.4	C1C[C@@H]([C@H](C[C@H]1N2CC3=C4N=CC=CN4N=C3C2)N)C5=C(C=CC(=C5)F)F	IC50 = 79000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	B8W6KN	2-[2-(3-(R)-Aminopiperidin-1-yl)-5-furan-3-yl-6-oxo-6H-pyrimidin-1-ylmethyl]benzonitrile	Investigative	11280296	C21H21N5O2	375.4	C1C[C@H](CN(C1)C2=NC=C(C(=O)N2CC3=CC=CC=C3C#N)C4=COC=C4)N	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	B8WDF1	(2S,3S)-2-Amino-3-[3-(2,4-difluorophenyl)-1,2,4-oxadiazol-5-yl]-1-(pyrrolidin-1-yl)butan-1-one	Investigative	23645700	C16H18F2N4O2	336.34	C[C@H](C1=NC(=NO1)C2=C(C=C(C=C2)F)F)[C@@H](C(=O)N3CCCC3)N	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	B8XN4U	(2S,3S)-2-Amino-3-(4-(3-chloropyridin-4-yl)phenyl)-1-((S)-3-fluoropyrrolidin-1-yl)butan-1-one	Investigative	44561011	C19H21ClFN3O	361.8	C[C@@H](C1=CC=C(C=C1)C2=C(C=NC=C2)Cl)[C@@H](C(=O)N3CC[C@@H](C3)F)N	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	B8Y3OT	N-[5-[(3R,5S,6R)-5-Amino-6-(2,5-difluorophenyl)oxan-3-yl]-4,6-dihydro-1H-pyrrolo[3,4-c]pyrazol-3-yl]cyclopropanesulfonamide	Investigative	127035744	C19H23F2N5O3S	439.5	C1CC1S(=O)(=O)NC2=NNC3=C2CN(C3)[C@@H]4C[C@@H]([C@H](OC4)C5=C(C=CC(=C5)F)F)N	IC50 = 91000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	B8Y6QH	(3R)-3-Amino-1-(1-methyl-4-(trifluoromethyl)-6,7-dihydro-1H-imidazo[4,5-c]pyridin-5(4H)-yl)-4-(2,4,5-trifluorophenyl)butan-1-one	Investigative	44443727	C18H18F6N4O	420.4	CN1C=NC2=C1CCN(C2C(F)(F)F)C(=O)C[C@@H](CC3=CC(=C(C=C3F)F)F)N	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	B8YMS5	N-[5-[(3R,5S,6R)-5-Amino-6-(2,5-difluorophenyl)oxan-3-yl]-4,6-dihydro-1H-pyrrolo[3,4-c]pyrazol-3-yl]-1H-imidazole-5-sulfonamide	Investigative	127035569	C19H21F2N7O3S	465.5	C1[C@H](CO[C@@H]([C@H]1N)C2=C(C=CC(=C2)F)F)N3CC4=C(C3)NN=C4NS(=O)(=O)C5=CN=CN5	IC50 = 62000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	B8ZLX7	(3R)-3-Amino-4-(2,5-difluorophenyl)-1-[3-(trifluoromethyl)-6,8-dihydro-5H-[1,2,4]triazolo[4,3-a]pyrazin-7-yl]butan-1-one;hydrochloride	Investigative	11418876	C16H17ClF5N5O	425.78	C1CN2C(=NN=C2C(F)(F)F)CN1C(=O)C[C@@H](CC3=C(C=CC(=C3)F)F)N.Cl	IC50 = 69000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	B90ANV	(2S,3S)-2-Amino-3-[4-(2,5-difluorophenyl)phenyl]-1-[(3S)-3-fluoropyrrolidin-1-yl]butan-1-one;2,2,2-trifluoroacetic acid	Investigative	49797083	C22H22F6N2O3	476.4	C[C@@H](C1=CC=C(C=C1)C2=C(C=CC(=C2)F)F)[C@@H](C(=O)N3CC[C@@H](C3)F)N.C(=O)(C(F)(F)F)O	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	B90XAK	(2R,3S,5R)-5-(1-Cyclopentylsulfonyl-4,6-dihydropyrrolo[3,4-c]pyrazol-5-yl)-2-(2,5-difluorophenyl)oxan-3-amine	Investigative	89488720	C21H26F2N4O3S	452.5	C1CCC(C1)S(=O)(=O)N2C3=C(CN(C3)[C@@H]4C[C@@H]([C@H](OC4)C5=C(C=CC(=C5)F)F)N)C=N2	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	B91SRQ	(2S,3S)-3-Amino-4-[(3S)-3-fluoropyrrolidin-1-yl]-N,N-dimethyl-4-oxo-2-[4-([1,2,4]triazolo[1,5-a]pyridin-7-yl)phenyl]butanamide;2,2,2-trifluoroacetic acid	Investigative	11720809	C24H26F4N6O4	538.5	CN(C)C(=O)[C@@H](C1=CC=C(C=C1)C2=CC3=NC=NN3C=C2)[C@@H](C(=O)N4CC[C@@H](C4)F)N.C(=O)(C(F)(F)F)O	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	B92INU	(2S)-2-Amino-3-[4-(4-fluorophenyl)phenyl]-1-[(3S)-3-fluoropyrrolidin-1-yl]propan-1-one;2,2,2-trifluoroacetic acid	Investigative	49796973	C21H21F5N2O3	444.4	C1CN(C[C@H]1F)C(=O)[C@H](CC2=CC=C(C=C2)C3=CC=C(C=C3)F)N.C(=O)(C(F)(F)F)O	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	B93HKQ	5-[4-[(2S,3S)-3-Amino-4-(3,3-difluoropyrrolidin-1-yl)-4-oxobutan-2-yl]phenyl]-1-methylpyridin-2-one;2,2,2-trifluoroacetic acid	Investigative	49797121	C22H24F5N3O4	489.4	C[C@@H](C1=CC=C(C=C1)C2=CN(C(=O)C=C2)C)[C@@H](C(=O)N3CCC(C3)(F)F)N.C(=O)(C(F)(F)F)O	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	B93KYB	3-[4-[(2S,3S)-3-Amino-4-[(3S)-3-fluoropyrrolidin-1-yl]-4-oxobutan-2-yl]phenyl]benzoic acid;2,2,2-trifluoroacetic acid	Investigative	49797089	C23H24F4N2O5	484.4	C[C@@H](C1=CC=C(C=C1)C2=CC(=CC=C2)C(=O)O)[C@@H](C(=O)N3CC[C@@H](C3)F)N.C(=O)(C(F)(F)F)O	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	B96ILJ	N-[4-[5-[(2S,3S)-3-Amino-4-[(3R)-3-fluoropyrrolidin-1-yl]-4-oxobutan-2-yl]-1,2,4-oxadiazol-3-yl]-3-chlorophenyl]methanesulfonamide;2,2,2-trifluoroacetic acid	Investigative	49797205	C19H22ClF4N5O6S	559.9	C[C@H](C1=NC(=NO1)C2=C(C=C(C=C2)NS(=O)(=O)C)Cl)[C@@H](C(=O)N3CC[C@H](C3)F)N.C(=O)(C(F)(F)F)O	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	B96ZUE	N-[4-[(1R)-1-Amino-2-(2,5-difluorophenyl)ethyl]cyclohexyl]-N,1-dimethylpyrazole-3-carboxamide	Investigative	53320180	C20H26F2N4O	376.4	CN1C=CC(=N1)C(=O)N(C)C2CCC(CC2)[C@@H](CC3=C(C=CC(=C3)F)F)N	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	B97IYO	(3S)-2-[(2S)-2-Amino-3-(1H-indol-3-yl)propanoyl]-3,4-dihydro-1H-isoquinoline-3-carbonitrile	Investigative	44390794	C21H20N4O	344.4	C1[C@H](N(CC2=CC=CC=C21)C(=O)[C@H](CC3=CNC4=CC=CC=C43)N)C#N	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	B97XNY	(S)-1-((3R,4R)-1-(4-(1-Methyl-1H-pyrazol-5-yl)benzyl)-3-aminopyrrolidine-4-carbonyl)pyrrolidine-2-carbonitrile	Investigative	44443348	C21H26N6O	378.5	CN1C(=CC=N1)C2=CC=C(C=C2)CN3C[C@H]([C@H](C3)N)C(=O)N4CCC[C@H]4C#N	IC50 = 148000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	B98DCM	(2R,3R)-2-Amino-N,N-dimethyl-3-(2,4,5-trifluorophenyl)-1,2,3,4-tetrahydropyrido[1,2-a]benzimidazole-7-carboxamide;2,2,2-trifluoroacetic acid	Investigative	49797599	C22H20F6N4O3	502.4	CN(C)C(=O)C1=CC2=C(C=C1)N3C[C@@H]([C@H](CC3=N2)C4=CC(=C(C=C4F)F)F)N.C(=O)(C(F)(F)F)O	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	B98HGU	5-[4-[(2S,3S)-3-Amino-4-(4-fluoropiperidin-1-yl)-4-oxobutan-2-yl]phenyl]-1-methylpyridin-2-one;2,2,2-trifluoroacetic acid	Investigative	49797109	C23H27F4N3O4	485.5	C[C@@H](C1=CC=C(C=C1)C2=CN(C(=O)C=C2)C)[C@@H](C(=O)N3CCC(CC3)F)N.C(=O)(C(F)(F)F)O	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	B9A2LO	trans-4-((4-((R)-1-Amino-2-(2,5-difluorophenyl)ethyl)cyclohexyl)(methyl)amino)-4-oxobutanoic acid	Investigative	53324144	C19H26F2N2O3	368.4	CN(C1CCC(CC1)[C@@H](CC2=C(C=CC(=C2)F)F)N)C(=O)CCC(=O)O	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	B9AE7Y	(2S,4S)-4-[[(3R)-3-Amino-4-(2,4,5-trifluorophenyl)butanoyl]amino]-1-[(2S)-2-[[(1S)-1-carboxy-3-phenylpropyl]amino]hexanoyl]pyrrolidine-2-carboxylic acid	Investigative	53354369	C31H39F3N4O6	620.7	CCCC[C@@H](C(=O)N1C[C@H](C[C@H]1C(=O)O)NC(=O)C[C@@H](CC2=CC(=C(C=C2F)F)F)N)N[C@@H](CCC3=CC=CC=C3)C(=O)O	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	B9B6PJ	CID 53312243	Investigative	53312243	C22H26N6O	390.5	CCC1=CC(=C2C(=N1)N(C(=O)N2CC3=CC=CC=C3C#N)C)N4CCC[C@H](C4)N	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	B9CJ4F	(2S,3S)-3-Amino-4-[(3S)-3-fluoropyrrolidin-1-yl]-N,N-dimethyl-2-[4-(3-methylsulfonylphenyl)phenyl]-4-oxobutanamide;2,2,2-trifluoroacetic acid	Investigative	49797039	C25H29F4N3O6S	575.6	CN(C)C(=O)[C@@H](C1=CC=C(C=C1)C2=CC(=CC=C2)S(=O)(=O)C)[C@@H](C(=O)N3CC[C@@H](C3)F)N.C(=O)(C(F)(F)F)O	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	B9D4VO	(2S,3S)-2-Amino-1-[(3S)-3-fluoropyrrolidin-1-yl]-3-[4-(4-methylsulfonylphenyl)phenyl]butan-1-one;2,2,2-trifluoroacetic acid	Investigative	49797093	C23H26F4N2O5S	518.5	C[C@@H](C1=CC=C(C=C1)C2=CC=C(C=C2)S(=O)(=O)C)[C@@H](C(=O)N3CC[C@@H](C3)F)N.C(=O)(C(F)(F)F)O	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	B9DG1Q	(2r)-4-[(8r)-8-Methyl-2-(Trifluoromethyl)-5,6-Dihydro[1,2,4]triazolo[1,5-A]pyrazin-7(8h)-Yl]-4-Oxo-1-(2,4,5-Trifluorophenyl)butan-2-Amine	Investigative	23661697	C17H17F6N5O	421.34	C[C@@H]1C2=NC(=NN2CCN1C(=O)C[C@@H](CC3=CC(=C(C=C3F)F)F)N)C(F)(F)F	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	B9FH4L	(R)-3-Amino-4-(2,5-difluorophenyl)-1-(3-methyl-2-(trifluoromethyl)-6,7-dihydro-3H-imidazo[4,5-c]pyridin-5(4H)-yl)butan-1-one	Investigative	44443709	C18H19F5N4O	402.4	CN1C2=C(CCN(C2)C(=O)C[C@@H](CC3=C(C=CC(=C3)F)F)N)N=C1C(F)(F)F	IC50 = 50000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	B9FUR8	2-[(3S,5S)-5-[(2S)-2-Cyanopyrrolidine-1-carbonyl]-2-oxopyrrolidin-3-yl]-N-phenylacetamide	Investigative	46916346	C18H20N4O3	340.4	C1C[C@H](N(C1)C(=O)[C@@H]2C[C@H](C(=O)N2)CC(=O)NC3=CC=CC=C3)C#N	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	B9HU0F	2-[[7-[(3R)-3-Aminopiperidin-1-yl]-5-methoxy-3-methyl-2-oxoimidazo[4,5-b]pyridin-1-yl]methyl]benzonitrile	Investigative	118712519	C21H24N6O2	392.5	CN1C2=C(C(=CC(=N2)OC)N3CCC[C@H](C3)N)N(C1=O)CC4=CC=CC=C4C#N	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	B9JP6T	2-[(3R,5S,6R)-5-Amino-6-(2,5-difluorophenyl)oxan-3-yl]-3H-isoindol-1-one	Investigative	73347698	C19H18F2N2O2	344.4	C1[C@H](CO[C@@H]([C@H]1N)C2=C(C=CC(=C2)F)F)N3CC4=CC=CC=C4C3=O	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	B9NAD3	(2S,4R)-4-(4-Chlorobenzylamino)-2-amino-5-methyl-1-(piperidin-1-yl)hexan-1-one	Investigative	44415906	C19H30ClN3O	351.9	CC(C)[C@@H](C[C@@H](C(=O)N1CCCCC1)N)NCC2=CC=C(C=C2)Cl	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	B9RV5B	2-[2-(3-(R)-Aminopiperidin-1-yl)-6-oxo-5-vinyl-6H-pyrimidin-1-ylmethyl]benzonitrile	Investigative	11461807	C19H21N5O	335.4	C=CC1=CN=C(N(C1=O)CC2=CC=CC=C2C#N)N3CCC[C@H](C3)N	IC50 = 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	B9T1CX	2-[[7-[(3R)-3-Aminopiperidin-1-yl]-2-oxo-3H-imidazo[4,5-b]pyridin-1-yl]methyl]benzonitrile	Investigative	53312328	C19H20N6O	348.4	C1C[C@H](CN(C1)C2=C3C(=NC=C2)NC(=O)N3CC4=CC=CC=C4C#N)N	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	B9TY0I	Sitagliptin Analog 13	Investigative	9843297	C16H16F5N5O	389.32	C1CN2C(=NN=C2C(F)(F)F)CN1C(=O)C[C@@H](CC3=C(C=CC(=C3)F)F)N	IC50 = 69000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	B9X8KE	(2S,3S)-2-Amino-1-[(3S)-3-fluoropyrrolidin-1-yl]-3-[4-[3-(tetrazol-1-yl)phenyl]phenyl]butan-1-one;2,2,2-trifluoroacetic acid	Investigative	49797077	C23H24F4N6O3	508.5	C[C@@H](C1=CC=C(C=C1)C2=CC(=CC=C2)N3C=NN=N3)[C@@H](C(=O)N4CC[C@@H](C4)F)N.C(=O)(C(F)(F)F)O	IC50 = 58000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	B9XMI1	2-({2-[(3R)-3-Aminopiperidin-1-yl]-7-fluoro-6-methoxy-4-oxo-3,4-dihydroquinazolin-3-yl}methyl)benzonitrile	Investigative	16658104	C22H22FN5O2	407.4	COC1=C(C=C2C(=C1)C(=O)N(C(=N2)N3CCC[C@H](C3)N)CC4=CC=CC=C4C#N)F	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	B9Z0PU	(3R,4R)-1-Isoquinolin-1-yl-4-(2,4,5-trifluorophenyl)piperidin-3-amine;2,2,2-trifluoroacetic acid	Investigative	49797237	C22H19F6N3O2	471.4	C1CN(C[C@@H]([C@H]1C2=CC(=C(C=C2F)F)F)N)C3=NC=CC4=CC=CC=C43.C(=O)(C(F)(F)F)O	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	B9Z4EB	(R)-3-Amino-4-(2,5-difluorophenyl)-1-(3-methyl-1,2,4-oxadiazol-5-yl)butan-1-one	Investigative	44561120	C13H13F2N3O2	281.26	CC1=NOC(=N1)C(=O)C[C@@H](CC2=C(C=CC(=C2)F)F)N	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	BA27WY	(3R)-3-Amino-4-(2,5-difluorophenyl)-1-[3-(trifluoromethyl)-4H,5H,6H,7H-pyrido[4,3-c][1,2]oxazol-5-yl]butan-1-one	Investigative	23645931	C17H16F5N3O2	389.32	C1CN(CC2=C(ON=C21)C(F)(F)F)C(=O)C[C@@H](CC3=C(C=CC(=C3)F)F)N	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	BA3XW8	4'-[(1r)-1-Amino-2-(2,5-Difluorophenyl)ethyl]biphenyl-3-Carboxamide	Investigative	24832041	C21H18F2N2O	352.4	C1=CC(=CC(=C1)C(=O)N)C2=CC=C(C=C2)[C@@H](CC3=C(C=CC(=C3)F)F)N	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	BA75NW	(3R)-1-(8-((1H-Imidazol-1-yl)methyl)-2-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[1,5-a]pyrazin-7(8H)-yl)-3-amino-4-(2,4,5-trifluorophenyl)butan-1-one	Investigative	44444386	C20H19F6N7O	487.4	C1CN2C(=NC(=N2)C(F)(F)F)C(N1C(=O)C[C@@H](CC3=CC(=C(C=C3F)F)F)N)CN4C=CN=C4	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	BA84EQ	(2R,3S,5S)-5-(9-Methyl-4,7,8,12-tetrazatricyclo[6.4.0.02,6]dodeca-1,6,9,11-tetraen-4-yl)-2-(2,4,5-trifluorophenyl)oxan-3-amine	Investigative	127048876	C20H20F3N5O	403.4	CC1=CC=NC2=C3CN(CC3=NN12)[C@H]4C[C@@H]([C@H](OC4)C5=CC(=C(C=C5F)F)F)N	IC50 = 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	BA9RN4	(2S,3S)-2-Amino-3-methyl-1-(5-nitroisoindolin-2-yl)pentan-1-one	Investigative	44560553	C14H19N3O3	277.32	CC[C@H](C)[C@@H](C(=O)N1CC2=C(C1)C=C(C=C2)[N+](=O)[O-])N	IC50 ~ 50000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	BAH72I	2-[2-(3-(R)-Aminopiperidin-1-yl)-6-oxo-4-phenyl-6H-pyrimidin-1-ylmethyl]benzonitrile	Investigative	11188314	C23H23N5O	385.5	C1C[C@H](CN(C1)C2=NC(=CC(=O)N2CC3=CC=CC=C3C#N)C4=CC=CC=C4)N	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	BAI82F	alpha-Amino acid pyrrolidide 28	Investigative	11603996	C17H21ClN4O4S	412.9	C[C@H](C1=NC(=NO1)C2=C(C=C(C=C2)S(=O)(=O)C)Cl)[C@@H](C(=O)N3CCCC3)N	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	BAL6F0	(2S,3S)-3-Amino-4-(3,3-difluoropyrrolidin-1-yl)-N,N-dimethyl-4-oxo-2-((1r,4S)-4-(5,6,7,8-tetrahydro-[1,2,4]triazolo[1,5-a]pyridin-6-yl)cyclohexyl)butanamide	Investigative	44433661	C22H34F2N6O2	452.5	CN(C)C(=O)[C@@H](C1CCC(CC1)C2CCC3=NC=NN3C2)[C@@H](C(=O)N4CCC(C4)(F)F)N	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	BAS40I	(2S,3S)-2-Amino-3-methyl-1-(5H-pyrrolo[3,4-b]pyridin-6(7H)-yl)pentan-1-one	Investigative	44560555	C13H19N3O	233.31	CC[C@H](C)[C@@H](C(=O)N1CC2=C(C1)N=CC=C2)N	IC50 = 56900 nM	Poor binder
T15855	Dipeptidyl peptidase 8	BAWY80	CID 53312238	Investigative	53312238	C21H22N6O3	406.4	CN1C2=C(C(=CC(=N2)C(=O)O)N3CCC[C@H](C3)N)N(C1=O)CC4=CC=CC=C4C#N	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	BAX78R	(2S,3R)-2-Amino-3-methyl-1-(5-(trifluoromethyl)isoindolin-2-yl)pentan-1-one	Investigative	44560597	C15H19F3N2O	300.32	CC[C@@H](C)[C@@H](C(=O)N1CC2=C(C1)C=C(C=C2)C(F)(F)F)N	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	BAZ27J	2-[(3R)-3-Aminopiperidin-1-yl]-3-[(2-chloro-5-fluorophenyl)methyl]-5-methyl-4-oxoimidazo[4,5-c]quinoline-7-carboxylic acid;hydrochloride	Investigative	71461809	C24H24Cl2FN5O3	520.4	CN1C2=C(C=CC(=C2)C(=O)O)C3=C(C1=O)N(C(=N3)N4CCC[C@H](C4)N)CC5=C(C=CC(=C5)F)Cl.Cl	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	BB06EK	(R)-3-Amino-4-(3-fluorophenyl)-1-(3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)butan-1-one	Investigative	44431165	C16H17F4N5O	371.33	C1CN2C(=NN=C2C(F)(F)F)CN1C(=O)C[C@@H](CC3=CC(=CC=C3)F)N	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	BB0E9I	(R)-3-Amino-4-(2,5-difluorophenyl)-1-(3-isobutyl-2-(trifluoromethyl)-6,7-dihydro-3H-imidazo[4,5-c]pyridin-5(4H)-yl)butan-1-one	Investigative	44443713	C21H25F5N4O	444.4	CC(C)CN1C2=C(CCN(C2)C(=O)C[C@@H](CC3=C(C=CC(=C3)F)F)N)N=C1C(F)(F)F	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	BB2M4K	5-[4-[(2S,3S)-3-Amino-4-[(3S)-3-fluoropyrrolidin-1-yl]-4-oxobutan-2-yl]phenyl]-1-ethylpyridin-2-one;2,2,2-trifluoroacetic acid	Investigative	49797117	C23H27F4N3O4	485.5	CCN1C=C(C=CC1=O)C2=CC=C(C=C2)[C@H](C)[C@@H](C(=O)N3CC[C@@H](C3)F)N.C(=O)(C(F)(F)F)O	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	BB2RX3	4-[[4-[(1R)-1-Amino-2-(2,5-difluorophenyl)ethyl]cyclohexyl]-methylsulfamoyl]benzamide	Investigative	53318841	C22H27F2N3O3S	451.5	CN(C1CCC(CC1)[C@@H](CC2=C(C=CC(=C2)F)F)N)S(=O)(=O)C3=CC=C(C=C3)C(=O)N	IC50 = 65000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	BB3P5E	(3R,4R)-1-Pteridin-7-yl-4-(2,4,5-trifluorophenyl)piperidin-3-amine;2,2,2-trifluoroacetic acid	Investigative	49797241	C19H16F6N6O2	474.4	C1CN(C[C@@H]([C@H]1C2=CC(=C(C=C2F)F)F)N)C3=NC4=NC=NC=C4N=C3.C(=O)(C(F)(F)F)O	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	BB78DK	(2S,3S)-2-Amino-3-(3-fluorophenyl)-1-[(3S)-3-fluoropyrrolidin-1-yl]butan-1-one;2,2,2-trifluoroacetic acid	Investigative	49797050	C16H19F5N2O3	382.33	C[C@@H](C1=CC(=CC=C1)F)[C@@H](C(=O)N2CC[C@@H](C2)F)N.C(=O)(C(F)(F)F)O	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	BB7GH4	(R)-3-Amino-4-(3-chlorophenyl)-1-(3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)butan-1-one	Investigative	44431200	C16H17ClF3N5O	387.79	C1CN2C(=NN=C2C(F)(F)F)CN1C(=O)C[C@@H](CC3=CC(=CC=C3)Cl)N	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	BB7XV5	(3s,5s)-3-[2-(1,3-Dihydro-2h-isoindol-2-yl)-2-oxoethyl]-5-(1,3-thiazolidin-3-ylcarbonyl)pyrrolidin-2-one	Investigative	46916387	C18H21N3O3S	359.4	C1CSCN1C(=O)[C@@H]2C[C@H](C(=O)N2)CC(=O)N3CC4=CC=CC=C4C3	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	BBGZ83	(2S,3S)-2-Amino-3-[4-(4-fluorophenyl)phenyl]-1-[(3S)-3-fluoropyrrolidin-1-yl]-4-hydroxybutan-1-one;2,2,2-trifluoroacetic acid	Investigative	49796985	C22H23F5N2O4	474.4	C1CN(C[C@H]1F)C(=O)[C@H]([C@@H](CO)C2=CC=C(C=C2)C3=CC=C(C=C3)F)N.C(=O)(C(F)(F)F)O	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	BBI25Z	(3R,4R)-1-Pyrazin-2-yl-4-(2,4,5-trifluorophenyl)piperidin-3-amine;2,2,2-trifluoroacetic acid	Investigative	49797234	C17H16F6N4O2	422.32	C1CN(C[C@@H]([C@H]1C2=CC(=C(C=C2F)F)F)N)C3=NC=CN=C3.C(=O)(C(F)(F)F)O	IC50 = 76000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	BBL4E3	2-[2-(3-(R)-Aminopiperidin-1-yl)-5-(2-fluorophenyl)-6-oxo-6Hpyrimidin-1-ylmethyl]benzonitrile	Investigative	11304224	C23H22FN5O	403.5	C1C[C@H](CN(C1)C2=NC=C(C(=O)N2CC3=CC=CC=C3C#N)C4=CC=CC=C4F)N	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	BBL8H4	(2R,3R,5R)-2-(2,5-Difluorophenyl)-5-(4,6-dihydro-1H-pyrrolo[3,4-c]pyrazol-5-yl)oxan-3-amine	Investigative	72188904	C16H18F2N4O	320.34	C1[C@H](CO[C@@H]([C@@H]1N)C2=C(C=CC(=C2)F)F)N3CC4=C(C3)NN=C4	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	BBQ08T	(1S,2R,5S)-5-(3-(Trifluoromethyl)-5,6-dihydroimidazo[1,2-a]pyrazin-7(8H)-yl)-2-(2,4,5-trifluorophenyl)cyclohexanamine	Investigative	44431316	C19H20F6N4	418.4	C1CC([C@H](C[C@H]1N2CCN3C(=NC=C3C(F)(F)F)C2)N)C4=CC(=C(C=C4F)F)F	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	BBV1F3	2-[[7-[(3R)-3-Aminopiperidin-1-yl]-3-methyl-2-oxo-5-(trifluoromethyl)imidazo[4,5-b]pyridin-1-yl]methyl]benzonitrile	Investigative	68305755	C21H21F3N6O	430.4	CN1C2=C(C(=CC(=N2)C(F)(F)F)N3CCC[C@H](C3)N)N(C1=O)CC4=CC=CC=C4C#N	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	BBV3X6	CID 53311222	Investigative	53311222	C21H24N6O	376.5	CN[C@@H]1CCCN(C1)C2=C3C(=NC=C2)N(C(=O)N3CC4=CC=CC=C4C#N)C	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	BBXW20	(2S,3S)-2-Amino-3-[3-(2-chloro-4-methylsulfonylphenyl)-1,2,4-oxadiazol-5-yl]-1-[(3S)-3-fluoropyrrolidin-1-yl]-5-hydroxypentan-1-one;2,2,2-trifluoroacetic acid	Investigative	49797197	C20H23ClF4N4O7S	574.9	CS(=O)(=O)C1=CC(=C(C=C1)C2=NOC(=N2)[C@@H](CCO)[C@@H](C(=O)N3CC[C@@H](C3)F)N)Cl.C(=O)(C(F)(F)F)O	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	BBZ48I	(3R)-3-Amino-1-[8-[[3,5-bis(trifluoromethyl)phenyl]methyl]-3-(trifluoromethyl)-6,8-dihydro-5H-[1,2,4]triazolo[4,3-a]pyrazin-7-yl]-4-(2,4,5-trifluorophenyl)butan-1-one;hydrochloride	Investigative	45263677	C25H20ClF12N5O	669.9	C1CN2C(=NN=C2C(F)(F)F)C(N1C(=O)C[C@@H](CC3=CC(=C(C=C3F)F)F)N)CC4=CC(=CC(=C4)C(F)(F)F)C(F)(F)F.Cl	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	BC0L9S	(2S,3S)-3-Amino-2-(4-(1,8a-dihydro-[1,2,4]triazolo[1,5-a]pyridin-6-yl)phenyl)-4-((S)-3-fluoropyrrolidin-1-yl)-N,N-dimethyl-4-oxobutanamide	Investigative	44590696	C22H27FN6O2	426.5	CN(C)C(=O)[C@@H](C1=CC=C(C=C1)C2=CN3C(C=C2)N=CN3)[C@@H](C(=O)N4CC[C@@H](C4)F)N	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	BC0PZ2	(1S,2R,5S)-5-(9-Methyl-4,7,8,12-tetrazatricyclo[6.4.0.02,6]dodeca-1,6,9,11-tetraen-4-yl)-2-(2,4,5-trifluorophenyl)cyclohexan-1-amine	Investigative	127049823	C21H22F3N5	401.4	CC1=CC=NC2=C3CN(CC3=NN12)[C@H]4CC[C@@H]([C@H](C4)N)C5=CC(=C(C=C5F)F)F	IC50 = 50000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	BC35UT	(2s)-1-({(2s,4s)-5-Oxo-4-[2-oxo-2-(pyrrolidin-1-yl)ethyl]pyrrolidin-2-yl}carbonyl)pyrrolidine-2-carbonitrile	Investigative	46916385	C16H22N4O3	318.37	C1CCN(C1)C(=O)C[C@@H]2C[C@H](NC2=O)C(=O)N3CCC[C@H]3C#N	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	BC7UG1	(2S,3S)-3-Amino-4-(3,3-difluoropyrrolidin-1-yl)-2-((1s,4R)-4-(2,6-dimethoxypyrimidin-4-yl)cyclohexyl)-N,N-dimethyl-4-oxobutanamide	Investigative	44433646	C22H33F2N5O4	469.5	CN(C)C(=O)[C@@H](C1CCC(CC1)C2=CC(=NC(=N2)OC)OC)[C@@H](C(=O)N3CCC(C3)(F)F)N	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	BC9MF7	(2S,3S)-2-Amino-3-[4-(4-fluorophenyl)phenyl]-1-[(3S)-3-fluoropyrrolidin-1-yl]butan-1-one;2,2,2-trifluoroacetic acid	Investigative	49796972	C22H23F5N2O3	458.4	C[C@@H](C1=CC=C(C=C1)C2=CC=C(C=C2)F)[C@@H](C(=O)N3CC[C@@H](C3)F)N.C(=O)(C(F)(F)F)O	IC50 = 87000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	BC9YH5	(R)-3-Amino-1-(2-cyclopropyl-5,6-dihydro-[1,2,4]triazolo[1,5-a]pyrazin-7(8H)-yl)-4-(2,4,5-trifluorophenyl)butan-1-one	Investigative	10429788	C18H20F3N5O	379.4	C1CC1C2=NN3CCN(CC3=N2)C(=O)C[C@@H](CC4=CC(=C(C=C4F)F)F)N	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	BCF37O	(R)-3-Amino-1-(5,6-dihydro-[1,2,4]triazolo[1,5-a]pyrazin-7(8H)-yl)-4-(2,4,5-trifluorophenyl)butan-1-one	Investigative	44444344	C15H16F3N5O	339.32	C1CN2C(=NC=N2)CN1C(=O)C[C@@H](CC3=CC(=C(C=C3F)F)F)N	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	BCJM04	(2R,3S,5R)-2-(2,5-Difluorophenyl)-5-[3-(trifluoromethyl)-6,8-dihydro-5H-[1,2,4]triazolo[4,3-a]pyrazin-7-yl]oxan-3-amine	Investigative	73353756	C17H18F5N5O	403.35	C1CN2C(=NN=C2C(F)(F)F)CN1[C@@H]3C[C@@H]([C@H](OC3)C4=C(C=CC(=C4)F)F)N	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	BCLU72	(R)-2-((2-(3-Aminopiperidin-1-yl)-5-fluoro-6-oxopyrimidin-1 (6H)-yl)methyl)-4-fluorobenzonitrile	Investigative	11233253	C17H17F2N5O	345.35	C1C[C@H](CN(C1)C2=NC=C(C(=O)N2CC3=C(C=CC(=C3)F)C#N)F)N	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	BCU2D7	(2R,3S,5R)-5-(2-Cyclopropyl-7,7-dimethyl-5H-pyrrolo[3,4-d]pyrimidin-6-yl)-2-(2,5-difluorophenyl)oxan-3-amine	Investigative	73353757	C22H26F2N4O	400.5	CC1(C2=NC(=NC=C2CN1[C@@H]3C[C@@H]([C@H](OC3)C4=C(C=CC(=C4)F)F)N)C5CC5)C	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	BCU5K0	(2R,3R)-7-Methoxy-3-(2,4,5-trifluorophenyl)-1,2,3,4-tetrahydropyrido[1,2-a]benzimidazol-2-amine;2,2,2-trifluoroacetic acid	Investigative	49797614	C20H17F6N3O3	461.4	COC1=CC2=C(C=C1)N3C[C@@H]([C@H](CC3=N2)C4=CC(=C(C=C4F)F)F)N.C(=O)(C(F)(F)F)O	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	BD17ZX	(2S,3S)-2-Amino-3-[4-(2-chlorophenyl)phenyl]-1-[(3S)-3-fluoropyrrolidin-1-yl]butan-1-one;2,2,2-trifluoroacetic acid	Investigative	49797091	C22H23ClF4N2O3	474.9	C[C@@H](C1=CC=C(C=C1)C2=CC=CC=C2Cl)[C@@H](C(=O)N3CC[C@@H](C3)F)N.C(=O)(C(F)(F)F)O	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	BD40BK	(2S,3S)-3-Amino-4-[(3S)-3-fluoropyrrolidin-1-yl]-N,N-dimethyl-4-oxo-2-[4-([1,2,4]triazolo[1,5-a]pyridin-6-yl)phenyl]butanamide;2,2,2-trifluoroacetic acid	Investigative	11570138	C24H26F4N6O4	538.5	CN(C)C(=O)[C@@H](C1=CC=C(C=C1)C2=CN3C(=NC=N3)C=C2)[C@@H](C(=O)N4CC[C@@H](C4)F)N.C(=O)(C(F)(F)F)O	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	BD51QE	(2S,3S)-2-Amino-3-(2-chloro-4-fluorophenyl)-1-[(3S)-3-fluoropyrrolidin-1-yl]butan-1-one;2,2,2-trifluoroacetic acid	Investigative	49797054	C16H18ClF5N2O3	416.77	C[C@@H](C1=C(C=C(C=C1)F)Cl)[C@@H](C(=O)N2CC[C@@H](C2)F)N.C(=O)(C(F)(F)F)O	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	BD5I2R	alpha-Amino acid pyrrolidide 18	Investigative	23645696	C17H19F3N4O4S	432.4	C[C@H](C1=NC(=NO1)C2=CC=C(C=C2)S(=O)(=O)C(F)(F)F)[C@@H](C(=O)N3CCCC3)N	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	BD5S0L	(2S,3S)-2-Amino-3-(3-(2-chloro-4-(methylsulfonyl)phenyl)-1,2,4-oxadiazol-5-yl)-1-((S)-3-fluoropyrrolidin-1-yl)butan-1-one	Investigative	23645721	C17H20ClFN4O4S	430.9	C[C@H](C1=NC(=NO1)C2=C(C=C(C=C2)S(=O)(=O)C)Cl)[C@@H](C(=O)N3CC[C@@H](C3)F)N	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	BD69UM	2-[[7-[(3R)-3-Aminopiperidin-1-yl]-3-methyl-5-morpholin-4-yl-2-oxoimidazo[4,5-b]pyridin-1-yl]methyl]benzonitrile	Investigative	118712522	C24H29N7O2	447.5	CN1C2=C(C(=CC(=N2)N3CCOCC3)N4CCC[C@H](C4)N)N(C1=O)CC5=CC=CC=C5C#N	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	BD70UI	(2R,3S,5R)-2-(2-Chlorophenyl)-5-(4,6-dihydro-1H-pyrrolo[3,4-c]pyrazol-5-yl)oxan-3-amine	Investigative	73353758	C16H19ClN4O	318.8	C1[C@H](CO[C@@H]([C@H]1N)C2=CC=CC=C2Cl)N3CC4=C(C3)NN=C4	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	BD78HT	Chembl4208513	Investigative	145964231	C17H19N5O	309.4	C1CN(CCN1)C2=CC(=O)N3C(=CC=N3)N2CC4=CC=CC=C4	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	BD89OJ	N-[4-[(1R)-1-Amino-2-(2,5-difluorophenyl)ethyl]cyclohexyl]-N-benzyl-3,5-dimethyl-1,2-oxazole-4-sulfonamide	Investigative	53324143	C26H31F2N3O3S	503.6	CC1=C(C(=NO1)C)S(=O)(=O)N(CC2=CC=CC=C2)C3CCC(CC3)[C@@H](CC4=C(C=CC(=C4)F)F)N	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	BD8HB2	(2S,3S)-3-Amino-N,N-dimethyl-4-oxo-4-pyrrolidin-1-yl-2-[4-([1,2,4]triazolo[1,5-a]pyridin-6-yl)phenyl]butanamide;2,2,2-trifluoroacetic acid	Investigative	11678025	C24H27F3N6O4	520.5	CN(C)C(=O)[C@@H](C1=CC=C(C=C1)C2=CN3C(=NC=N3)C=C2)[C@@H](C(=O)N4CCCC4)N.C(=O)(C(F)(F)F)O	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	BD9VO1	(2S,3S)-2-Amino-1-[(3S)-3-fluoropyrrolidin-1-yl]-3-[4-[3-(1,3,4-oxadiazol-2-yl)phenyl]phenyl]butan-1-one;2,2,2-trifluoroacetic acid	Investigative	49797069	C24H24F4N4O4	508.5	C[C@@H](C1=CC=C(C=C1)C2=CC(=CC=C2)C3=NN=CO3)[C@@H](C(=O)N4CC[C@@H](C4)F)N.C(=O)(C(F)(F)F)O	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	BDA9K4	[6-Bromo-5-(2-chlorophenyl)-3-methylbenzimidazol-4-yl]methanamine	Investigative	11559371	C15H13BrClN3	350.64	CN1C=NC2=CC(=C(C(=C21)CN)C3=CC=CC=C3Cl)Br	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	BDF92Z	2-({2-[(3R)-3-Aminopiperidin-1-yl]-7-chloro-4-oxo-3,4-dihydroquinazolin-3-yl}methyl)benzonitrile	Investigative	16658024	C21H20ClN5O	393.9	C1C[C@H](CN(C1)C2=NC3=C(C=CC(=C3)Cl)C(=O)N2CC4=CC=CC=C4C#N)N	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	BDJQ81	(R)-1-(4-(1-Amino-2-(2,5-difluorophenyl)ethyl)piperidin-1-yl)ethanone	Investigative	53317581	C15H20F2N2O	282.33	CC(=O)N1CCC(CC1)[C@@H](CC2=C(C=CC(=C2)F)F)N	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	BDQ72X	(2S,3S)-2-Amino-3-methyl-1-(5-(trifluoromethyl)isoindolin-2-yl)pentan-1-one	Investigative	44560550	C15H19F3N2O	300.32	CC[C@H](C)[C@@H](C(=O)N1CC2=C(C1)C=C(C=C2)C(F)(F)F)N	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	BDV19Y	(2S,3S)-2-Amino-3-(3-chloro-4-fluorophenyl)-1-[(3S)-3-fluoropyrrolidin-1-yl]butan-1-one;2,2,2-trifluoroacetic acid	Investigative	49797051	C16H18ClF5N2O3	416.77	C[C@@H](C1=CC(=C(C=C1)F)Cl)[C@@H](C(=O)N2CC[C@@H](C2)F)N.C(=O)(C(F)(F)F)O	IC50 = 57000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	BE1A6T	Imigliptin	Investigative	53311070	C21H24N6O	376.5	CC1=CC(=C2C(=N1)N(C(=O)N2CC3=CC=CC=C3C#N)C)N4CCC[C@H](C4)N	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	BE4N7Q	2-[[7-[(3R)-3-Aminopiperidin-1-yl]-3-methyl-2-oxo-5-pyrrolidin-1-ylimidazo[4,5-b]pyridin-1-yl]methyl]benzonitrile	Investigative	118712521	C24H29N7O	431.5	CN1C2=C(C(=CC(=N2)N3CCCC3)N4CCC[C@H](C4)N)N(C1=O)CC5=CC=CC=C5C#N	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	BE5GK7	6-[(3R)-3-Aminopiperidin-1-yl]-3-(benzo[f]quinolin-3-ylmethyl)-1-but-2-ynylpyrimidine-2,4-dione	Investigative	71731243	C27H27N5O2	453.5	CC#CCN1C(=CC(=O)N(C1=O)CC2=NC3=C(C=C2)C4=CC=CC=C4C=C3)N5CCC[C@H](C5)N	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	BE7KO5	Diphenyl 1-((S)-2,4-diaminobutanoyl)pyrrolidin-2-ylphosphonate	Investigative	44435310	C20H26N3O4P	403.4	C1CC(N(C1)C(=O)[C@H](CCN)N)P(=O)(OC2=CC=CC=C2)OC3=CC=CC=C3	IC50 = 86000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	BE8I5O	2-[7-[(3R)-3-Amino-4-(2,4,5-trifluorophenyl)butanoyl]-3-(trifluoromethyl)-6,8-dihydro-5H-[1,2,4]triazolo[4,3-a]pyrazin-8-yl]-N,N-dimethylacetamide;hydrochloride	Investigative	45263693	C20H23ClF6N6O2	528.9	CN(C)C(=O)CC1C2=NN=C(N2CCN1C(=O)C[C@@H](CC3=CC(=C(C=C3F)F)F)N)C(F)(F)F.Cl	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	BEH42K	2-[[7-[(3R)-3-Aminopyrrolidin-1-yl]-3-methyl-2-oxoimidazo[4,5-b]pyridin-1-yl]methyl]benzonitrile	Investigative	53312326	C19H20N6O	348.4	CN1C2=NC=CC(=C2N(C1=O)CC3=CC=CC=C3C#N)N4CC[C@H](C4)N	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	BEJ2I4	N-[5-[(3R,5S,6R)-5-Amino-6-(2,5-difluorophenyl)oxan-3-yl]-4,6-dihydro-1H-pyrrolo[3,4-c]pyrazol-3-yl]-2,2,2-trifluoroethanesulfonamide	Investigative	127035743	C18H20F5N5O3S	481.4	C1[C@H](CO[C@@H]([C@H]1N)C2=C(C=CC(=C2)F)F)N3CC4=C(C3)NN=C4NS(=O)(=O)CC(F)(F)F	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	BEK3T0	(3R)-4-[(3R)-3-Amino-4-(2,4,5-trifluorophenyl)butanoyl]-3-(pyrazin-2-ylmethyl)-1,4-diazepan-2-one	Investigative	44418114	C20H22F3N5O2	421.4	C1CNC(=O)[C@H](N(C1)C(=O)C[C@@H](CC2=CC(=C(C=C2F)F)F)N)CC3=NC=CN=C3	IC50 = 80000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	BEMP08	(3R)-3-Amino-1-[8-[(4-methoxyphenyl)methyl]-3-(trifluoromethyl)-6,8-dihydro-5H-[1,2,4]triazolo[4,3-a]pyrazin-7-yl]-4-(2,4,5-trifluorophenyl)butan-1-one;hydrochloride	Investigative	45265945	C24H24ClF6N5O2	563.9	COC1=CC=C(C=C1)CC2C3=NN=C(N3CCN2C(=O)C[C@@H](CC4=CC(=C(C=C4F)F)F)N)C(F)(F)F.Cl	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	BEO4P7	(2S)-N-Tert-butyl-1-[(2S,4S)-4-[2-(1,3-dihydroisoindol-2-yl)-2-oxoethyl]-5-oxopyrrolidine-2-carbonyl]pyrrolidine-2-carboxamide	Investigative	46938499	C24H32N4O4	440.5	CC(C)(C)NC(=O)[C@@H]1CCCN1C(=O)[C@@H]2C[C@H](C(=O)N2)CC(=O)N3CC4=CC=CC=C4C3	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	BEV48M	(2S,4R)-4-(4-Chlorobenzylamino)-2-amino-1-(piperidin-1-yl)pentan-1-one	Investigative	44415883	C17H26ClN3O	323.9	C[C@H](C[C@@H](C(=O)N1CCCCC1)N)NCC2=CC=C(C=C2)Cl	IC50 = 65000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	BF0D1S	US9051329, Example 1	Investigative	71203752	C21H21F4N7O2	479.4	CN1C(=O)CN2C1=NC3=C(C2=O)N(C(=N3)N4CCC[C@H](C4)N)CC5=C(C=CC(=C5)F)C(F)(F)F	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	BF0LN1	(2S)-1-({(2S,4S)-5-Oxo-4-[2-oxo-2-[3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]ethyl]pyrrolidin-2-yl}carbonyl)pyrrolidine-2-carbonitrile	Investigative	46916386	C18H20F3N7O3	439.4	C1C[C@H](N(C1)C(=O)[C@@H]2C[C@H](C(=O)N2)CC(=O)N3CCN4C(=NN=C4C(F)(F)F)C3)C#N	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	BF1KC2	(2S,3S)-2-Amino-3-(3-phenyl-1,2,4-oxadiazol-5-yl)-1-(pyrrolidin-1-yl)butan-1-one	Investigative	23645686	C16H20N4O2	300.36	C[C@H](C1=NC(=NO1)C2=CC=CC=C2)[C@@H](C(=O)N3CCCC3)N	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	BF21GD	trans-N-(4-((R)-1-Amino-2-(2,5-difluorophenyl)ethyl)cyclohexyl)-N-benzylmethanesulfonamide	Investigative	53326705	C22H28F2N2O2S	422.5	CS(=O)(=O)N(CC1=CC=CC=C1)C2CCC(CC2)[C@@H](CC3=C(C=CC(=C3)F)F)N	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	BF2NY7	1-[6-[(3R,4R)-3-Amino-4-(2,4,5-trifluorophenyl)piperidin-1-yl]pyridin-3-yl]-4-phenylmethoxypyridin-2-one	Investigative	57404374	C28H25F3N4O2	506.5	C1CN(C[C@@H]([C@H]1C2=CC(=C(C=C2F)F)F)N)C3=NC=C(C=C3)N4C=CC(=CC4=O)OCC5=CC=CC=C5	IC50 ~ 50000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	BF3IO2	(3R,6R)-4-[(3R)-3-Amino-4-(2,4,5-trifluorophenyl)butanoyl]-3,6-dimethyl-1,4-diazepan-2-one	Investigative	23647123	C17H22F3N3O2	357.37	C[C@@H]1CNC(=O)[C@H](N(C1)C(=O)C[C@@H](CC2=CC(=C(C=C2F)F)F)N)C	IC50 = 93000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	BF41BR	1-Isoleucylazetidine	Investigative	10607253	C9H18N2O	170.25	CC[C@H](C)[C@@H](C(=O)N1CCC1)N	IC50 = 127000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	BF4H8B	6-[(3R)-3-Aminopiperidin-1-yl]-1-but-2-ynyl-3-[(4-chloroquinolin-2-yl)methyl]pyrimidine-2,4-dione	Investigative	72707537	C23H24ClN5O2	437.9	CC#CCN1C(=CC(=O)N(C1=O)CC2=NC3=CC=CC=C3C(=C2)Cl)N4CCC[C@H](C4)N	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	BF5N8E	(R)-3-Amino-4-(2,5-difluorophenyl)-1-(1-isobutyl-2-(trifluoromethyl)-6,7-dihydro-1H-imidazo[4,5-c]pyridin-5(4H)-yl)butan-1-one	Investigative	44443712	C21H25F5N4O	444.4	CC(C)CN1C2=C(CN(CC2)C(=O)C[C@@H](CC3=C(C=CC(=C3)F)F)N)N=C1C(F)(F)F	IC50 = 54000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	BF81CI	(3R)-3-Amino-1-[8-(pyridin-2-ylmethyl)-3-(trifluoromethyl)-6,8-dihydro-5H-[1,2,4]triazolo[4,3-a]pyrazin-7-yl]-4-(2,4,5-trifluorophenyl)butan-1-one;hydrochloride	Investigative	45263687	C22H21ClF6N6O	534.9	C1CN2C(=NN=C2C(F)(F)F)C(N1C(=O)C[C@@H](CC3=CC(=C(C=C3F)F)F)N)CC4=CC=CC=N4.Cl	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	BFEW57	(2R,3S,5R)-5-(11-Methyl-4,7,8,12-tetrazatricyclo[6.4.0.02,6]dodeca-1,6,9,11-tetraen-4-yl)-2-(2,4,5-trifluorophenyl)oxan-3-amine	Investigative	127050132	C20H20F3N5O	403.4	CC1=NC2=C3CN(CC3=NN2C=C1)[C@@H]4C[C@@H]([C@H](OC4)C5=CC(=C(C=C5F)F)F)N	IC50 = 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	BFI0Y3	(2r,3s,5r)-2-(2,5-Difluorophenyl)-5-(7h-Pyrrolo[3',4':3,4]pyrazolo[1,5-A]pyrimidin-8(9h)-Yl)oxan-3-Amine	Investigative	24951732	C19H19F2N5O	371.4	C1[C@H](CO[C@@H]([C@H]1N)C2=C(C=CC(=C2)F)F)N3CC4=C5N=CC=CN5N=C4C3	IC50 = 91000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	BFO13R	4-[(1R)-1-Amino-2-(2,5-difluorophenyl)ethyl]-N-benzyl-N-(4,4,4-trifluorobutyl)cyclohexan-1-amine	Investigative	53322824	C25H31F5N2	454.5	C1CC(CCC1[C@@H](CC2=C(C=CC(=C2)F)F)N)N(CCCC(F)(F)F)CC3=CC=CC=C3	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	BFQT80	(2S,3S)-2-Amino-1-(5-tert-butylisoindolin-2-yl)-3-methylpentan-1-one	Investigative	44560549	C18H28N2O	288.4	CC[C@H](C)[C@@H](C(=O)N1CC2=C(C1)C=C(C=C2)C(C)(C)C)N	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	BFU9M0	IP5Pms7gwy	Investigative	11957945	C16H16F5N5O	389.32	C1CN2C(=NN=C2C(F)(F)F)CN1C(=O)C[C@@H](CC3=C(C=C(C=C3)F)F)N	IC50 = 83000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	BFX7G6	(2R,3S,5R)-2-(2,5-Difluorophenyl)-5-[2-(trifluoromethylsulfonyl)-4,6-dihydropyrrolo[3,4-c]pyrazol-5-yl]oxan-3-amine	Investigative	127035239	C17H17F5N4O3S	452.4	C1[C@H](CO[C@@H]([C@H]1N)C2=C(C=CC(=C2)F)F)N3CC4=CN(N=C4C3)S(=O)(=O)C(F)(F)F	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	BFZ06R	(S)-N-(2-(2-Cyanopyrrolidin-1-yl)-2-oxoethyl)-1-naphthamide	Investigative	16040457	C18H17N3O2	307.3	C1C[C@H](N(C1)C(=O)CNC(=O)C2=CC=CC3=CC=CC=C32)C#N	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	BG25IT	2-[2-(3-(R)-Aminopiperidin-1-yl)-6-oxo-5-(1H-pyrrol-3-yl)-6Hpyrimidin-1-ylmethyl]benzonitrile	Investigative	11164704	C21H22N6O	374.4	C1C[C@H](CN(C1)C2=NC=C(C(=O)N2CC3=CC=CC=C3C#N)C4=CNC=C4)N	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	BG26SJ	(3R)-3-Amino-1-(4-ethyl-1-methyl-2-(trifluoromethyl)-6,7-dihydro-1H-imidazo[4,5-c]pyridin-5(4H)-yl)-4-(2,4,5-trifluorophenyl)butan-1-one	Investigative	44443723	C20H22F6N4O	448.4	CCC1C2=C(CCN1C(=O)C[C@@H](CC3=CC(=C(C=C3F)F)F)N)N(C(=N2)C(F)(F)F)C	IC50 = 55000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	BG31QW	(2S,3S)-2-Amino-3-[3-(4-bromo-2-chlorophenyl)-1,2,4-oxadiazol-5-yl]-1-(pyrrolidin-1-yl)butan-1-one	Investigative	23645702	C16H18BrClN4O2	413.7	C[C@H](C1=NC(=NO1)C2=C(C=C(C=C2)Br)Cl)[C@@H](C(=O)N3CCCC3)N	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	BG6J2Y	[5-(2-Chlorophenyl)-3-methylbenzimidazol-4-yl]methanamine	Investigative	11708829	C15H14ClN3	271.74	CN1C=NC2=C1C(=C(C=C2)C3=CC=CC=C3Cl)CN	IC50 = 50000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	BG8E7P	(R)-3-Amino-1-((R)-8-(cyclopropylfluoromethyl)-2-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[1,5-a]pyrazin-7(8H)-yl)-4-(2,4,5-trifluorophenyl)butan-1-one	Investigative	44444383	C20H20F7N5O	479.4	C1CC1C([C@H]2C3=NC(=NN3CCN2C(=O)C[C@@H](CC4=CC(=C(C=C4F)F)F)N)C(F)(F)F)F	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	BGB94E	(2S,3S)-2-Amino-3-[4-(2,4-difluorophenyl)phenyl]-1-[(3S)-3-fluoropyrrolidin-1-yl]butan-1-one;2,2,2-trifluoroacetic acid	Investigative	49797090	C22H22F6N2O3	476.4	C[C@@H](C1=CC=C(C=C1)C2=C(C=C(C=C2)F)F)[C@@H](C(=O)N3CC[C@@H](C3)F)N.C(=O)(C(F)(F)F)O	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	BGBA76	N-[4-[(1R)-1-Amino-2-(2,5-difluorophenyl)ethyl]cyclohexyl]-N-methyl-4-(trifluoromethoxy)benzenesulfonamide	Investigative	53317566	C22H25F5N2O3S	492.5	CN(C1CCC(CC1)[C@@H](CC2=C(C=CC(=C2)F)F)N)S(=O)(=O)C3=CC=C(C=C3)OC(F)(F)F	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	BGCW21	3-[2-(2-Cyanopyrrolidin-1-yl)-2-oxo-ethylamino]-3-methyl-N-(1-methyl-1-phenylethyl)butyramide	Investigative	11624893	C21H30N4O2	370.5	CC(C)(CC(=O)NC(C)(C)C1=CC=CC=C1)NCC(=O)N2CCC[C@H]2C#N	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	BGE06L	N-[4-[(2S,3S)-3-Amino-1-(dimethylamino)-4-[(3S)-3-fluoropyrrolidin-1-yl]-1,4-dioxobutan-2-yl]cyclohexyl]-3-fluoro-N-methylbenzamide;hydrochloride	Investigative	49797358	C24H35ClF2N4O3	501	CN(C)C(=O)[C@@H](C1CCC(CC1)N(C)C(=O)C2=CC(=CC=C2)F)[C@@H](C(=O)N3CC[C@@H](C3)F)N.Cl	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	BGE0F8	2-[2-(3-(R)-Aminopyrimidin-1-yl)-5-bromo-6-oxo-6H-pyrimidin-1-ylmethyl]thiophene-3-carbonitrile	Investigative	11234800	C15H16BrN5OS	394.3	C1C[C@H](CN(C1)C2=NC=C(C(=O)N2CC3=C(C=CS3)C#N)Br)N	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	BGH23B	N-[4-[(1R)-1-Amino-2-(2,5-difluorophenyl)ethyl]cyclohexyl]-N-methyl-4-(1,3-oxazol-5-yl)benzenesulfonamide	Investigative	53324130	C24H27F2N3O3S	475.6	CN(C1CCC(CC1)[C@@H](CC2=C(C=CC(=C2)F)F)N)S(=O)(=O)C3=CC=C(C=C3)C4=CN=CO4	IC50 = 76000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	BGJ52O	(2S,3S)-2-Amino-3-(4-chloro-2-fluorophenyl)-1-[(3S)-3-fluoropyrrolidin-1-yl]butan-1-one;2,2,2-trifluoroacetic acid	Investigative	49797043	C16H18ClF5N2O3	416.77	C[C@@H](C1=C(C=C(C=C1)Cl)F)[C@@H](C(=O)N2CC[C@@H](C2)F)N.C(=O)(C(F)(F)F)O	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	BGM51N	(R)-3-Amino-1-((R)-8-(cyclopropylmethyl)-2-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[1,5-a]pyrazin-7(8H)-yl)-4-(2,4,5-trifluorophenyl)butan-1-one	Investigative	44444375	C20H21F6N5O	461.4	C1CC1C[C@@H]2C3=NC(=NN3CCN2C(=O)C[C@@H](CC4=CC(=C(C=C4F)F)F)N)C(F)(F)F	IC50 = 71000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	BGQ0I1	(2S,3S)-3-Amino-4-(3,3-difluoropyrrolidin-1-yl)-N,N-dimethyl-4-oxo-2-[4-([1,2,4]triazolo[1,5-a]pyridin-6-yl)phenyl]butanamide;2,2,2-trifluoroacetic acid	Investigative	11649741	C24H25F5N6O4	556.5	CN(C)C(=O)[C@@H](C1=CC=C(C=C1)C2=CN3C(=NC=N3)C=C2)[C@@H](C(=O)N4CCC(C4)(F)F)N.C(=O)(C(F)(F)F)O	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	BGU6X1	2-[4-[[[(4R)-3-[3-Amino-4-(2-fluorophenyl)butanoyl]-1,3-thiazolidine-4-carbonyl]amino]methyl]phenyl]acetic acid;2,2,2-trifluoroacetic acid	Investigative	49796940	C25H27F4N3O6S	573.6	C1[C@H](N(CS1)C(=O)CC(CC2=CC=CC=C2F)N)C(=O)NCC3=CC=C(C=C3)CC(=O)O.C(=O)(C(F)(F)F)O	IC50 ~ 50000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	BH0DP8	(2S,3S)-3-Amino-2-[4-(4-fluorophenyl)phenyl]-4-[(3S)-3-fluoropyrrolidin-1-yl]-N,N-dimethyl-4-oxobutanamide;2,2,2-trifluoroacetic acid	Investigative	49796999	C24H26F5N3O4	515.5	CN(C)C(=O)[C@@H](C1=CC=C(C=C1)C2=CC=C(C=C2)F)[C@@H](C(=O)N3CC[C@@H](C3)F)N.C(=O)(C(F)(F)F)O	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	BH0K1R	(3R,7S)-4-[(3R)-3-Amino-4-(2,4,5-trifluorophenyl)butanoyl]-3,7-dimethyl-1,4-diazepan-2-one	Investigative	23647124	C17H22F3N3O2	357.37	C[C@H]1CCN([C@@H](C(=O)N1)C)C(=O)C[C@@H](CC2=CC(=C(C=C2F)F)F)N	IC50 = 70000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	BH23IQ	(2S,3S)-2-Amino-3-(3,5-difluorophenyl)-1-[(3S)-3-fluoropyrrolidin-1-yl]butan-1-one;2,2,2-trifluoroacetic acid	Investigative	49797046	C16H18F6N2O3	400.32	C[C@@H](C1=CC(=CC(=C1)F)F)[C@@H](C(=O)N2CC[C@@H](C2)F)N.C(=O)(C(F)(F)F)O	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	BH26MI	cis-(R)-2-(2,5-Difluorophenyl)-1-(4-(3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)cyclohexyl)ethanamine	Investigative	53317579	C20H24F5N5	429.4	C1CC(CCC1[C@@H](CC2=C(C=CC(=C2)F)F)N)N3CCN4C(=NN=C4C(F)(F)F)C3	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	BH2RU0	(2S,3S)-3-Amino-4-[(3S)-3-fluoropyrrolidin-1-yl]-N,N-dimethyl-4-oxo-2-[4-(4-pyridin-1-ium-1-ylphenyl)phenyl]butanamide;2,2,2-trifluoroacetate	Investigative	45266135	C29H30F4N4O4	574.6	CN(C)C(=O)[C@@H](C1=CC=C(C=C1)C2=CC=C(C=C2)[N+]3=CC=CC=C3)[C@@H](C(=O)N4CC[C@@H](C4)F)N.C(=O)(C(F)(F)F)[O-]	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	BH3WU2	2-[[7-(3-Aminoazetidin-1-yl)-3-methyl-2-oxoimidazo[4,5-b]pyridin-1-yl]methyl]benzonitrile	Investigative	53312327	C18H18N6O	334.4	CN1C2=NC=CC(=C2N(C1=O)CC3=CC=CC=C3C#N)N4CC(C4)N	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	BH43EZ	4-[[7-[(3R)-3-Aminopiperidin-1-yl]-3-methyl-2-oxoimidazo[4,5-b]pyridin-1-yl]methyl]benzonitrile	Investigative	53311143	C20H22N6O	362.4	CN1C2=NC=CC(=C2N(C1=O)CC3=CC=C(C=C3)C#N)N4CCC[C@H](C4)N	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	BH50EA	(2S,3S,5R)-2-(2,5-Difluorophenyl)-5-(4,6-dihydro-1H-pyrrolo[3,4-c]pyrazol-5-yl)oxan-3-amine	Investigative	72193504	C16H18F2N4O	320.34	C1[C@H](CO[C@H]([C@H]1N)C2=C(C=CC(=C2)F)F)N3CC4=C(C3)NN=C4	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	BH50KZ	(3R)-3-Amino-1-(2-benzoyldiazinan-1-yl)-4-(2,4,5-trifluorophenyl)butan-1-one;hydrochloride	Investigative	23628283	C21H23ClF3N3O2	441.9	C1CCN(N(C1)C(=O)C[C@@H](CC2=CC(=C(C=C2F)F)F)N)C(=O)C3=CC=CC=C3.Cl	IC50 = 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	BHC0V1	N-[4-[(1R)-1-Amino-2-(2,5-difluorophenyl)ethyl]cyclohexyl]-N-methyl-4-(thiadiazol-4-yl)benzenesulfonamide	Investigative	51346971	C23H26F2N4O2S2	492.6	CN(C1CCC(CC1)[C@@H](CC2=C(C=CC(=C2)F)F)N)S(=O)(=O)C3=CC=C(C=C3)C4=CSN=N4	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	BHC67B	(3R)-3-Amino-4-(2,5-difluorophenyl)-1-[3-(1,1,2,2,2-pentafluoroethyl)-1H,4H,5H,6H,7H-pyrazolo[4,3-c]pyridin-5-yl]butan-1-one	Investigative	23645925	C18H17F7N4O	438.3	C1CN(CC2=C1NN=C2C(C(F)(F)F)(F)F)C(=O)C[C@@H](CC3=C(C=CC(=C3)F)F)N	IC50 = 72000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	BHC7X8	7-[(3R,4R)-3-Amino-4-(2,4,5-trifluorophenyl)piperidin-1-yl]-2-methylpyrimido[1,2-b]pyridazin-4-one;2,2,2-trifluoroacetic acid	Investigative	49797248	C21H19F6N5O3	503.4	CC1=CC(=O)N2C(=N1)C=CC(=N2)N3CC[C@@H]([C@H](C3)N)C4=CC(=C(C=C4F)F)F.C(=O)(C(F)(F)F)O	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	BHEK84	(2S,3S)-2-Amino-1-(3-hydroxypyrrolidin-1-yl)-3-methylpentan-1-one	Investigative	10845727	C10H20N2O2	200.28	CC[C@H](C)[C@@H](C(=O)N1CCC(C1)O)N	IC50 = 130000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	BHF51R	2-[2-(3-(R)-Aminopiperidin-1-yl)-5-methoxy-6-oxo-6H-pyrimidin-1-ylmethyl]benzonitrile	Investigative	11484559	C18H21N5O2	339.4	COC1=CN=C(N(C1=O)CC2=CC=CC=C2C#N)N3CCC[C@H](C3)N	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	BHM07N	(3R)-3-Amino-4-(2,5-difluorophenyl)-1-[2-(2,2,2-trifluoroethyl)-3-(trifluoromethyl)-2H,4H,5H,6H,7H-pyrazolo[4,3-c]pyridin-5-yl]butan-1-one	Investigative	23645922	C19H18F8N4O	470.4	C1CN(CC2=C(N(N=C21)CC(F)(F)F)C(F)(F)F)C(=O)C[C@@H](CC3=C(C=CC(=C3)F)F)N	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	BHO96J	(R)-3-Amino-1-((S)-2-(3-tert-butyl-1,2,4-oxadiazol-5-yl)pyrrolidin-1-yl)-4-(2,4,5-trifluorophenyl)butan-1-one	Investigative	45487888	C20H25F3N4O2	410.4	CC(C)(C)C1=NOC(=N1)[C@@H]2CCCN2C(=O)C[C@@H](CC3=CC(=C(C=C3F)F)F)N	IC50 = 52000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	BHPD40	cis-1-(4-((R)-1-Amino-2-(2,5-difluorophenyl)ethyl)cyclohexyl)piperidine-3-carboxamide	Investigative	53317580	C20H29F2N3O	365.5	C1CC(CN(C1)C2CCC(CC2)[C@@H](CC3=C(C=CC(=C3)F)F)N)C(=O)N	IC50 = 68000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	BHSQ63	6-[(3R)-3-Aminopiperidin-1-yl]-1-but-2-ynyl-3-[(7-fluoroquinolin-2-yl)methyl]pyrimidine-2,4-dione	Investigative	71731605	C23H24FN5O2	421.5	CC#CCN1C(=CC(=O)N(C1=O)CC2=NC3=C(C=CC(=C3)F)C=C2)N4CCC[C@H](C4)N	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	BI09LO	(2R,3R)-7-Methyl-3-(2,4,5-trifluorophenyl)-1,2,3,4-tetrahydropyrido[1,2-a]benzimidazol-2-amine;2,2,2-trifluoroacetic acid	Investigative	49797644	C20H17F6N3O2	445.4	CC1=CC2=C(C=C1)N3C[C@@H]([C@H](CC3=N2)C4=CC(=C(C=C4F)F)F)N.C(=O)(C(F)(F)F)O	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	BI1ZT8	(2S,3R)-2-Amino-3-[4-(4-fluorophenyl)phenyl]-1-[(3S)-3-fluoropyrrolidin-1-yl]-4-(tetrazol-1-yl)butan-1-one;2,2,2-trifluoroacetic acid	Investigative	49797001	C23H23F5N6O3	526.5	C1CN(C[C@H]1F)C(=O)[C@H]([C@@H](CN2C=NN=N2)C3=CC=C(C=C3)C4=CC=C(C=C4)F)N.C(=O)(C(F)(F)F)O	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	BI24DG	2-({2-[(3R)-3-Aminopiperidin-1-yl]-6-chloro-4-oxo-3,4-dihydroquinazolin-3-yl}methyl)benzonitrile	Investigative	16658023	C21H20ClN5O	393.9	C1C[C@H](CN(C1)C2=NC3=C(C=C(C=C3)Cl)C(=O)N2CC4=CC=CC=C4C#N)N	IC50 ~ 50000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	BI30SK	N-[4-[(1R)-1-Amino-2-(2,5-difluorophenyl)ethyl]cyclohexyl]-N-methylpyridine-3-sulfonamide	Investigative	53318856	C20H25F2N3O2S	409.5	CN(C1CCC(CC1)[C@@H](CC2=C(C=CC(=C2)F)F)N)S(=O)(=O)C3=CN=CC=C3	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	BI6H3W	(3R)-3-Amino-4-(2,5-difluorophenyl)-1-(1,4-dimethyl-2-(trifluoromethyl)-6,7-dihydro-1H-imidazo[4,5-c]pyridin-5(4H)-yl)butan-1-one	Investigative	44443720	C19H21F5N4O	416.4	CC1C2=C(CCN1C(=O)C[C@@H](CC3=C(C=CC(=C3)F)F)N)N(C(=N2)C(F)(F)F)C	IC50 = 64000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	BI7JG0	(2R,3S,5R)-2-(2,5-Difluorophenyl)-5-(2-propan-2-ylsulfonyl-4,6-dihydropyrrolo[3,4-c]pyrazol-5-yl)oxan-3-amine	Investigative	127035242	C19H24F2N4O3S	426.5	CC(C)S(=O)(=O)N1C=C2CN(CC2=N1)[C@@H]3C[C@@H]([C@H](OC3)C4=C(C=CC(=C4)F)F)N	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	BI7RW2	(2S)-1-[(2S)-2-Amino-3-thiophen-3-ylpropanoyl]pyrrolidine-2-carbonitrile	Investigative	76311138	C12H15N3OS	249.33	C1C[C@H](N(C1)C(=O)[C@H](CC2=CSC=C2)N)C#N	IC50 = 55700 nM	Poor binder
T15855	Dipeptidyl peptidase 8	BI9J3L	US9051329, Example 7	Investigative	71203742	C21H23F2N7O2	443.4	CCN1C(=O)CN2C1=NC3=C(C2=O)N(C(=N3)N4CCC[C@H](C4)N)CC5=C(C=CC(=C5)F)F	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	BIA7D0	(R)-3-Amino-4-(2,5-difluorophenyl)-1-(1-methyl-2-(trifluoromethyl)-6,7-dihydro-1H-imidazo[4,5-c]pyridin-5(4H)-yl)butan-1-one	Investigative	44443708	C18H19F5N4O	402.4	CN1C2=C(CN(CC2)C(=O)C[C@@H](CC3=C(C=CC(=C3)F)F)N)N=C1C(F)(F)F	IC50 = 68000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	BID3T2	(3R)-3-Amino-1-[8-benzyl-3-(trifluoromethyl)-6,8-dihydro-5H-[1,2,4]triazolo[4,3-a]pyrazin-7-yl]-4-(2,4,5-trifluorophenyl)butan-1-one;hydrochloride	Investigative	45265943	C23H22ClF6N5O	533.9	C1CN2C(=NN=C2C(F)(F)F)C(N1C(=O)C[C@@H](CC3=CC(=C(C=C3F)F)F)N)CC4=CC=CC=C4.Cl	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	BIG41S	trans-(R)-1-(4-((R)-1-Amino-2-(2,5-difluorophenyl)ethyl)cyclohexyl)piperidin-3-yl carbamate	Investigative	53318864	C20H29F2N3O2	381.5	C1C[C@H](CN(C1)C2CCC(CC2)[C@@H](CC3=C(C=CC(=C3)F)F)N)OC(=O)N	IC50 = 58000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	BIJ47Q	6-[(3R)-3-Aminopiperidin-1-yl]-1-[(2,5-dichlorophenyl)methyl]-3-methylpyrimidine-2,4-dione	Investigative	11222807	C17H20Cl2N4O2	383.3	CN1C(=O)C=C(N(C1=O)CC2=C(C=CC(=C2)Cl)Cl)N3CCC[C@H](C3)N	IC50 = 86000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	BIM9C6	(11R,12R)-11-(2,4,5-Trifluorophenyl)-1,5,8-triazatricyclo[7.4.0.02,7]trideca-2(7),3,5,8-tetraen-12-amine;hydrochloride	Investigative	45270905	C16H14ClF3N4	354.76	C1[C@@H]([C@H](CN2C1=NC3=C2C=CN=C3)N)C4=CC(=C(C=C4F)F)F.Cl	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	BIQ86J	4-{5-[(2S,3S)-3-Amino-4-oxo-4-(pyrrolidin-1-yl)butan-2-yl]-1,2,4-oxadiazol-3-yl}benzene-1-sulfonamide	Investigative	23645697	C16H21N5O4S	379.4	C[C@H](C1=NC(=NO1)C2=CC=C(C=C2)S(=O)(=O)N)[C@@H](C(=O)N3CCCC3)N	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	BJ1X8B	(R)-3-Amino-1-((R)-8-(cyclopropyl(hydroxy)methyl)-2-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[1,5-a]pyrazin-7(8H)-yl)-4-(2,4,5-trifluorophenyl)butan-1-one	Investigative	44444377	C20H21F6N5O2	477.4	C1CC1C([C@H]2C3=NC(=NN3CCN2C(=O)CC(CC4=CC(=C(C=C4F)F)F)N)C(F)(F)F)O	IC50 = 86000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	BJ1ZB7	(2S)-1-[(2S,4S)-4-[2-(1,3-Dihydroisoindol-2-yl)-2-oxoethyl]-5-oxopyrrolidine-2-carbonyl]pyrrolidine-2-carboxamide	Investigative	46938602	C20H24N4O4	384.4	C1C[C@H](N(C1)C(=O)[C@@H]2C[C@H](C(=O)N2)CC(=O)N3CC4=CC=CC=C4C3)C(=O)N	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	BJ29TQ	trans-3-(((4-((R)-1-Amino-2-(2,5-difluorophenyl)ethyl)cyclohexyl)(methyl)amino)methyl)benzonitrile	Investigative	53322822	C23H27F2N3	383.5	CN(CC1=CC(=CC=C1)C#N)C2CCC(CC2)[C@@H](CC3=C(C=CC(=C3)F)F)N	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	BJ63OZ	(2S,3S)-3-Amino-4-[(3S)-3-fluoropyrrolidin-1-yl]-N,N-dimethyl-4-oxo-2-[4-[[4-(trifluoromethoxy)phenyl]sulfonylamino]cyclohexyl]butanamide;hydrochloride	Investigative	49797356	C23H33ClF4N4O5S	589	CN(C)C(=O)[C@@H](C1CCC(CC1)NS(=O)(=O)C2=CC=C(C=C2)OC(F)(F)F)[C@@H](C(=O)N3CC[C@@H](C3)F)N.Cl	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	BJ9P6U	(2S)-1-(2-{[4-(6,8-Difluoro-1,2,3,4-tetrahydroisoquinolin-2-yl)-2-methyl-4-oxobutan-2-yl]amino}acetyl)pyrrolidine-2-carbonitrile	Investigative	11538673	C21H26F2N4O2	404.5	CC(C)(CC(=O)N1CCC2=C(C1)C(=CC(=C2)F)F)NCC(=O)N3CCC[C@H]3C#N	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	BJF84U	(2S)-1-[3-Amino-4-(2-fluorophenyl)butanoyl]-N-[4-(2H-tetrazol-5-yl)butyl]pyrrolidine-2-carboxamide;2,2,2-trifluoroacetic acid	Investigative	49796942	C22H29F4N7O4	531.5	C1C[C@H](N(C1)C(=O)CC(CC2=CC=CC=C2F)N)C(=O)NCCCCC3=NNN=N3.C(=O)(C(F)(F)F)O	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	BJMX76	1-[6-[(3R)-3-Aminopyrrolidin-1-yl]pyridin-3-yl]-4-phenylmethoxypyridin-2-one	Investigative	24963343	C21H22N4O2	362.4	C1CN(C[C@@H]1N)C2=NC=C(C=C2)N3C=CC(=CC3=O)OCC4=CC=CC=C4	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	BJU0F1	(2R,3R)-7-Methylsulfonyl-3-(2,4,5-trifluorophenyl)-1,2,3,4-tetrahydropyrido[1,2-a]benzimidazol-2-amine;2,2,2-trifluoroacetic acid	Investigative	49797605	C20H17F6N3O4S	509.4	CS(=O)(=O)C1=CC2=C(C=C1)N3C[C@@H]([C@H](CC3=N2)C4=CC(=C(C=C4F)F)F)N.C(=O)(C(F)(F)F)O	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	BJXK70	(2S)-1-({(2S,4S)-4-[2-(1,3-Dihydro-2H-isoindol-2-yl)-2-oxoethyl]-5-oxopyrrolidin-2-yl}carbonyl)pyrrolidine-2-carbonitrile	Investigative	46893990	C20H22N4O3	366.4	C1C[C@H](N(C1)C(=O)[C@@H]2C[C@H](C(=O)N2)CC(=O)N3CC4=CC=CC=C4C3)C#N	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	BK47RM	(2S)-2-Amino-4-[4-[bis(4-fluorophenyl)methyl]piperazin-1-yl]-1-(4,6-dihydro-1H-pyrrolo[3,4-c]pyrazol-5-yl)butane-1,4-dione;2,2,2-trifluoroacetic acid	Investigative	127047762	C28H29F5N6O4	608.6	C1CN(CCN1C(C2=CC=C(C=C2)F)C3=CC=C(C=C3)F)C(=O)C[C@@H](C(=O)N4CC5=C(C4)NN=C5)N.C(=O)(C(F)(F)F)O	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	BK4A8W	(2S,3S)-2-Amino-1-[(3S)-3-fluoropyrrolidin-1-yl]-3-[4-[2-(trifluoromethyl)phenyl]phenyl]butan-1-one;2,2,2-trifluoroacetic acid	Investigative	49797080	C23H23F7N2O3	508.4	C[C@@H](C1=CC=C(C=C1)C2=CC=CC=C2C(F)(F)F)[C@@H](C(=O)N3CC[C@@H](C3)F)N.C(=O)(C(F)(F)F)O	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	BK82BX	(2R,3R)-1-(2,5-Difluorophenyl)-3-(3-(4-(trifluoromethoxy)phenyl)-1,2,4-oxadiazol-5-yl)butan-2-amine	Investigative	44561152	C19H16F5N3O2	413.3	C[C@@H](C1=NC(=NO1)C2=CC=C(C=C2)OC(F)(F)F)[C@@H](CC3=C(C=CC(=C3)F)F)N	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	BK86NO	(3R)-3-Amino-1-[8-[(4-fluorophenyl)-hydroxymethyl]-3-(trifluoromethyl)-6,8-dihydro-5H-[1,2,4]triazolo[4,3-a]pyrazin-7-yl]-4-(2,4,5-trifluorophenyl)butan-1-one;hydrochloride	Investigative	45263680	C23H21ClF7N5O2	567.9	C1CN2C(=NN=C2C(F)(F)F)C(N1C(=O)C[C@@H](CC3=CC(=C(C=C3F)F)F)N)C(C4=CC=C(C=C4)F)O.Cl	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	BKB15R	(1S,2R,5R)-5-(3-(Trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)-2-(2,4,5-trifluorophenyl)cyclohexanamine	Investigative	44431317	C18H19F6N5	419.4	C1CC([C@H](C[C@@H]1N2CCN3C(=NN=C3C(F)(F)F)C2)N)C4=CC(=C(C=C4F)F)F	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	BKJ3G5	N-[4-[5-[(2S,3S)-3-Amino-4-oxo-4-pyrrolidin-1-ylbutan-2-yl]-1,2,4-oxadiazol-3-yl]-3-chlorophenyl]methanesulfonamide;2,2,2-trifluoroacetic acid	Investigative	49797192	C19H23ClF3N5O6S	541.9	C[C@H](C1=NC(=NO1)C2=C(C=C(C=C2)NS(=O)(=O)C)Cl)[C@@H](C(=O)N3CCCC3)N.C(=O)(C(F)(F)F)O	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	BKO4P9	(2S,3S)-2-Amino-3-[3-(2-chloro-4-fluorophenyl)-1,2,4-oxadiazol-5-yl]-1-(pyrrolidin-1-yl)butan-1-one	Investigative	23645703	C16H18ClFN4O2	352.79	C[C@H](C1=NC(=NO1)C2=C(C=C(C=C2)F)Cl)[C@@H](C(=O)N3CCCC3)N	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	BKP69A	(S)-1-((3R,4R)-1-(4-(1,2,3-Thiadiazol-4-yl)benzyl)-3-aminopyrrolidine-4-carbonyl)pyrrolidine-2-carbonitrile	Investigative	44443356	C19H22N6OS	382.5	C1C[C@H](N(C1)C(=O)[C@@H]2CN(C[C@@H]2N)CC3=CC=C(C=C3)C4=CSN=N4)C#N	IC50 = 190000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	BKTJ82	(2S,3S)-2-Amino-1-(pyrrolidin-1-yl)-3-{3-[4-(trifluoromethoxy)phenyl]-1,2,4-oxadiazol-5-yl}butan-1-one	Investigative	23645694	C17H19F3N4O3	384.35	C[C@H](C1=NC(=NO1)C2=CC=C(C=C2)OC(F)(F)F)[C@@H](C(=O)N3CCCC3)N	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	BKTP80	(3S,5S)-3-[2-(1,3-Dihydroisoindol-2-yl)-2-oxoethyl]-5-(pyrrolidine-1-carbonyl)pyrrolidin-2-one	Investigative	46938802	C19H23N3O3	341.4	C1CCN(C1)C(=O)[C@@H]2C[C@H](C(=O)N2)CC(=O)N3CC4=CC=CC=C4C3	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	BKX07S	(1S,2R,5S)-2-(2,5-Difluorophenyl)-5-(11-methyl-1,5,8,12-tetrazatricyclo[7.3.0.03,7]dodeca-2,7,9,11-tetraen-5-yl)cyclohexan-1-amine	Investigative	127052286	C21H23F2N5	383.4	CC1=NN2C=C3CN(CC3=NC2=C1)[C@H]4CC[C@@H]([C@H](C4)N)C5=C(C=CC(=C5)F)F	IC50 = 63000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	BKZ7S0	5-[4-[(2S,3S)-3-Amino-4-[(3S)-3-fluoropyrrolidin-1-yl]-4-oxobutan-2-yl]phenyl]-3-bromo-1,6-dimethylpyridin-2-one;2,2,2-trifluoroacetic acid	Investigative	49797113	C23H26BrF4N3O4	564.4	CC1=C(C=C(C(=O)N1C)Br)C2=CC=C(C=C2)[C@H](C)[C@@H](C(=O)N3CC[C@@H](C3)F)N.C(=O)(C(F)(F)F)O	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	BL2ZD8	(2S,3S)-2-Amino-1-[(3S)-3-fluoropyrrolidin-1-yl]-3-(4-piperidin-1-ylphenyl)butan-1-one;2,2,2-trifluoroacetic acid	Investigative	49797041	C21H29F4N3O3	447.5	C[C@@H](C1=CC=C(C=C1)N2CCCCC2)[C@@H](C(=O)N3CC[C@@H](C3)F)N.C(=O)(C(F)(F)F)O	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	BL3AK0	(2S)-2-[4-[[[(2S)-1-[(3R)-3-Amino-4-(2,5-difluorophenyl)butanoyl]pyrrolidine-2-carbonyl]amino]methyl]phenoxy]-3-methylbutanoic acid;2,2,2-trifluoroacetic acid	Investigative	44590735	C29H34F5N3O7	631.6	CC(C)[C@@H](C(=O)O)OC1=CC=C(C=C1)CNC(=O)[C@@H]2CCCN2C(=O)C[C@@H](CC3=C(C=CC(=C3)F)F)N.C(=O)(C(F)(F)F)O	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	BL7B5H	6-[(3R,4R)-3-Amino-4-(2,4,5-trifluorophenyl)piperidin-1-yl]-2-methyl-[1,2,4]triazolo[4,3-b]pyridazin-3-one;2,2,2-trifluoroacetic acid	Investigative	49797249	C19H18F6N6O3	492.4	CN1C(=O)N2C(=N1)C=CC(=N2)N3CC[C@@H]([C@H](C3)N)C4=CC(=C(C=C4F)F)F.C(=O)(C(F)(F)F)O	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	BL82BN	(3R)-3-Amino-4-(2,5-difluorophenyl)-1-[3-(4-fluorophenyl)-2-methyl-2H,4H,5H,6H,7H-pyrazolo[4,3-c]pyridin-5-yl]butan-1-one	Investigative	23645930	C23H23F3N4O	428.4	CN1C(=C2CN(CCC2=N1)C(=O)C[C@@H](CC3=C(C=CC(=C3)F)F)N)C4=CC=C(C=C4)F	IC50 = 58000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	BLC51D	(2S,3S)-2-Amino-3-[3-(2,4-dichlorophenyl)-1H-1,2,4-triazol-5-yl]-1-pyrrolidin-1-ylbutan-1-one;2,2,2-trifluoroacetic acid	Investigative	49797203	C18H20Cl2F3N5O3	482.3	C[C@H](C1=NC(=NN1)C2=C(C=C(C=C2)Cl)Cl)[C@@H](C(=O)N3CCCC3)N.C(=O)(C(F)(F)F)O	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	BLF7O5	(R)-3-Amino-4-(perfluorophenyl)-1-(3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)butan-1-one	Investigative	44431185	C16H13F8N5O	443.29	C1CN2C(=NN=C2C(F)(F)F)CN1C(=O)C[C@@H](CC3=C(C(=C(C(=C3F)F)F)F)F)N	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	BLI7U0	6-[(3R)-3-Aminopiperidin-1-yl]-1,3-bis(but-2-ynyl)pyrimidine-2,4-dione	Investigative	72707536	C17H22N4O2	314.4	CC#CCN1C(=CC(=O)N(C1=O)CC#CC)N2CCC[C@H](C2)N	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	BLP38T	N-[4-[(1R)-1-Amino-2-(2,5-difluorophenyl)ethyl]cyclohexyl]-N-methyl-1,2-oxazole-5-carboxamide	Investigative	53324153	C19H23F2N3O2	363.4	CN(C1CCC(CC1)[C@@H](CC2=C(C=CC(=C2)F)F)N)C(=O)C3=CC=NO3	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	BLW9G8	(2S,4S)-4-[[(3R)-3-Amino-4-(2,4,5-trifluorophenyl)butanoyl]amino]-1-[(2S)-2-[[(1S)-1-carboxy-3-phenylpropyl]amino]pentanoyl]pyrrolidine-2-carboxylic acid	Investigative	53354365	C30H37F3N4O6	606.6	CCC[C@@H](C(=O)N1C[C@H](C[C@H]1C(=O)O)NC(=O)C[C@@H](CC2=CC(=C(C=C2F)F)F)N)N[C@@H](CCC3=CC=CC=C3)C(=O)O	IC50 = 57000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	BLX1U3	Ethyl 4-[4-[(2S,3S)-3-amino-4-[(3S)-3-fluoropyrrolidin-1-yl]-4-oxobutan-2-yl]phenyl]benzoate;2,2,2-trifluoroacetic acid	Investigative	49797087	C25H28F4N2O5	512.5	CCOC(=O)C1=CC=C(C=C1)C2=CC=C(C=C2)[C@H](C)[C@@H](C(=O)N3CC[C@@H](C3)F)N.C(=O)(C(F)(F)F)O	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	BM04GD	(2R,3S,5R)-5-(2-Cyclopropylsulfonyl-4,6-dihydropyrrolo[3,4-c]pyrazol-5-yl)-2-(2,5-difluorophenyl)oxan-3-amine	Investigative	46209134	C19H22F2N4O3S	424.5	C1CC1S(=O)(=O)N2C=C3CN(CC3=N2)[C@@H]4C[C@@H]([C@H](OC4)C5=C(C=CC(=C5)F)F)N	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	BM19LG	2-({2-[(3R)-3-Aminopiperidin-1-yl]-6-methoxy-4-oxo-3,4-dihydroquinazolin-3-yl}methyl)benzonitrile	Investigative	16658103	C22H23N5O2	389.4	COC1=CC2=C(C=C1)N=C(N(C2=O)CC3=CC=CC=C3C#N)N4CCC[C@H](C4)N	IC50 ~ 50000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	BM23RN	N-[4-[(1R)-1-Amino-2-(2,5-difluorophenyl)ethyl]cyclohexyl]-2,4-difluoro-N-methylbenzenesulfonamide	Investigative	53318842	C21H24F4N2O2S	444.5	CN(C1CCC(CC1)[C@@H](CC2=C(C=CC(=C2)F)F)N)S(=O)(=O)C3=C(C=C(C=C3)F)F	IC50 = 55000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	BM52VH	N-[4-[(1R)-1-Amino-2-(2,5-difluorophenyl)ethyl]cyclohexyl]-N-(4,4,4-trifluorobutyl)methanesulfonamide	Investigative	53324293	C19H27F5N2O2S	442.5	CS(=O)(=O)N(CCCC(F)(F)F)C1CCC(CC1)[C@@H](CC2=C(C=CC(=C2)F)F)N	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	BM7EP3	(R)-3-Amino-4-(4-fluorophenyl)-1-(3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)butan-1-one	Investigative	44431166	C16H17F4N5O	371.33	C1CN2C(=NN=C2C(F)(F)F)CN1C(=O)C[C@@H](CC3=CC=C(C=C3)F)N	IC50 = 65000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	BM95IQ	(3R,6R)-4-[(3R)-3-Amino-4-(2,4,5-trifluorophenyl)butanoyl]-6-methyl-3-(2,2,2-trifluoroethyl)-1,4-diazepan-2-one	Investigative	23647128	C18H21F6N3O2	425.4	C[C@@H]1CNC(=O)[C@H](N(C1)C(=O)C[C@@H](CC2=CC(=C(C=C2F)F)F)N)CC(F)(F)F	IC50 = 89000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	BM9TH5	Ethyl 2-[5-[4-[(2S,3S)-3-amino-4-[(3S)-3-fluoropyrrolidin-1-yl]-4-oxobutan-2-yl]phenyl]-2-oxopyridin-1-yl]-2,2-difluoroacetate;2,2,2-trifluoroacetic acid	Investigative	49797124	C25H27F6N3O6	579.5	CCOC(=O)C(N1C=C(C=CC1=O)C2=CC=C(C=C2)[C@H](C)[C@@H](C(=O)N3CC[C@@H](C3)F)N)(F)F.C(=O)(C(F)(F)F)O	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	BM9XC7	6-[(3R,4R)-3-Amino-4-(2,4,5-trifluorophenyl)piperidin-1-yl]-2-methyl-3H-pyrido[3,2-d]pyrimidin-4-one;2,2,2-trifluoroacetic acid	Investigative	136177302	C21H19F6N5O3	503.4	CC1=NC2=C(C(=O)N1)N=C(C=C2)N3CC[C@@H]([C@H](C3)N)C4=CC(=C(C=C4F)F)F.C(=O)(C(F)(F)F)O	IC50 = 80000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	BMK76N	(2S,3S)-2-Amino-1-[(3S)-3-fluoropyrrolidin-1-yl]-3-[4-(4-methylphenyl)phenyl]butan-1-one;2,2,2-trifluoroacetic acid	Investigative	49797079	C23H26F4N2O3	454.5	CC1=CC=C(C=C1)C2=CC=C(C=C2)[C@H](C)[C@@H](C(=O)N3CC[C@@H](C3)F)N.C(=O)(C(F)(F)F)O	IC50 = 77000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	BMN1I4	2-({2-[(3r)-3-Aminopiperidin-1-Yl]-5-Bromo-6-Oxopyrimidin-1(6h)-Yl}methyl)benzonitrile	Investigative	11246214	C17H18BrN5O	388.3	C1C[C@H](CN(C1)C2=NC=C(C(=O)N2CC3=CC=CC=C3C#N)Br)N	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	BN25GB	(2S,3S)-3-Amino-4-(3-fluoroazetidin-1-yl)-2-[4-(4-fluorophenyl)phenyl]-N,N-dimethyl-4-oxobutanamide;2,2,2-trifluoroacetic acid	Investigative	49797016	C23H24F5N3O4	501.4	CN(C)C(=O)[C@@H](C1=CC=C(C=C1)C2=CC=C(C=C2)F)[C@@H](C(=O)N3CC(C3)F)N.C(=O)(C(F)(F)F)O	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	BN29ML	(2R,3S,5R)-5-[9-(Trifluoromethyl)-4,7,8,12-tetrazatricyclo[6.4.0.02,6]dodeca-1,6,9,11-tetraen-4-yl]-2-(2,4,5-trifluorophenyl)oxan-3-amine	Investigative	127049179	C20H17F6N5O	457.4	C1[C@H](CO[C@@H]([C@H]1N)C2=CC(=C(C=C2F)F)F)N3CC4=C5N=CC=C(N5N=C4C3)C(F)(F)F	IC50 = 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	BN2US1	(R)-1-(4-Bromophenyl)-2-(2,5-difluorophenyl)ethanamine	Investigative	44561008	C14H12BrF2N	312.15	C1=CC(=CC=C1[C@@H](CC2=C(C=CC(=C2)F)F)N)Br	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	BN2VT4	(2S,3S)-3-Amino-4-(azetidin-1-yl)-2-[4-(4-fluorophenyl)phenyl]-N,N-dimethyl-4-oxobutanamide;2,2,2-trifluoroacetic acid	Investigative	49797022	C23H25F4N3O4	483.5	CN(C)C(=O)[C@@H](C1=CC=C(C=C1)C2=CC=C(C=C2)F)[C@@H](C(=O)N3CCC3)N.C(=O)(C(F)(F)F)O	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	BN2ZW1	(2S,3S)-2-Amino-3-(3-(2,4-dichlorophenyl)-1,2,4-oxadiazol-5-yl)-1-((S)-3-fluoropyrrolidin-1-yl)butan-1-one	Investigative	44561153	C16H17Cl2FN4O2	387.2	C[C@H](C1=NC(=NO1)C2=C(C=C(C=C2)Cl)Cl)[C@@H](C(=O)N3CC[C@@H](C3)F)N	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	BN4VB2	(2S,3S)-2-[4-[Acetyl(methyl)amino]cyclohexyl]-3-amino-4-[(3S)-3-fluoropyrrolidin-1-yl]-N,N-dimethyl-4-oxobutanamide;hydrochloride	Investigative	49797361	C19H34ClFN4O3	420.9	CC(=O)N(C)C1CCC(CC1)[C@@H]([C@@H](C(=O)N2CC[C@@H](C2)F)N)C(=O)N(C)C.Cl	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	BN52FT	(R)-2-(2,5-Difluorophenyl)-1-(4-(pyridin-4-yl)phenyl)ethanamine	Investigative	44561009	C19H16F2N2	310.3	C1=CC(=CC=C1C2=CC=NC=C2)[C@@H](CC3=C(C=CC(=C3)F)F)N	IC50 = 64000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	BN6U7T	3-[4-[(2S,3S)-3-Amino-4-[(3S)-3-fluoropyrrolidin-1-yl]-4-oxobutan-2-yl]phenyl]benzenesulfonamide;2,2,2-trifluoroacetic acid	Investigative	49797074	C22H25F4N3O5S	519.5	C[C@@H](C1=CC=C(C=C1)C2=CC(=CC=C2)S(=O)(=O)N)[C@@H](C(=O)N3CC[C@@H](C3)F)N.C(=O)(C(F)(F)F)O	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	BN6W3U	(2S,4S)-4-(4-Chlorobenzylamino)-2-amino-1-(piperidin-1-yl)hexan-1-one	Investigative	44415905	C18H28ClN3O	337.9	CC[C@@H](C[C@@H](C(=O)N1CCCCC1)N)NCC2=CC=C(C=C2)Cl	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	BN71BJ	2-[2-(3-(R)-Aminopiperidin-1-yl)-5-iodo-6-oxo-6H-pyrimidin-1-ylmethyl]benzonitrile	Investigative	11419146	C17H18IN5O	435.26	C1C[C@H](CN(C1)C2=NC=C(C(=O)N2CC3=CC=CC=C3C#N)I)N	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	BN71KS	(R)-3-Amino-4-(2,5-difluorophenyl)-1-(1-ethyl-2-(trifluoromethyl)-6,7-dihydro-1H-imidazo[4,5-c]pyridin-5(4H)-yl)butan-1-one	Investigative	44443710	C19H21F5N4O	416.4	CCN1C2=C(CN(CC2)C(=O)C[C@@H](CC3=C(C=CC(=C3)F)F)N)N=C1C(F)(F)F	IC50 = 58000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	BNH8A6	[(2R)-1-[(2S)-3-Methyl-2-(pyridine-3-carbonylamino)butanoyl]pyrrolidin-2-yl]boronic acid	Investigative	71655395	C15H22BN3O4	319.17	B([C@@H]1CCCN1C(=O)[C@H](C(C)C)NC(=O)C2=CN=CC=C2)(O)O	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	BNI5M3	7-(Aminomethyl)-6-(2-Chlorophenyl)-1-Methyl-1h-Benzimidazole-5-Carbonitrile	Investigative	11572962	C16H13ClN4	296.75	CN1C=NC2=C1C(=C(C(=C2)C#N)C3=CC=CC=C3Cl)CN	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	BNI7A8	(2S,3S)-3-Amino-4-[(3S)-3-fluoropyrrolidin-1-yl]-N,N-dimethyl-4-oxo-2-[4-([1,2,4]triazolo[4,3-a]pyridin-6-yl)phenyl]butanamide;2,2,2-trifluoroacetic acid	Investigative	11577431	C24H26F4N6O4	538.5	CN(C)C(=O)[C@@H](C1=CC=C(C=C1)C2=CN3C=NN=C3C=C2)[C@@H](C(=O)N4CC[C@@H](C4)F)N.C(=O)(C(F)(F)F)O	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	BNO3Q4	(3R)-3-Amino-4-(2,5-difluorophenyl)-1-[2-methyl-3-(trifluoromethyl)-2H,4H,5H,6H,7H-pyrazolo[4,3-c]pyridin-5-yl]butan-1-one	Investigative	23645920	C18H19F5N4O	402.4	CN1C(=C2CN(CCC2=N1)C(=O)C[C@@H](CC3=C(C=CC(=C3)F)F)N)C(F)(F)F	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	BNQS12	(R)-3-Amino-4-(2,5-dichlorophenyl)-1-(3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)butan-1-one	Investigative	44431205	C16H16Cl2F3N5O	422.2	C1CN2C(=NN=C2C(F)(F)F)CN1C(=O)C[C@@H](CC3=C(C=CC(=C3)Cl)Cl)N	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	BNRT25	2-[2-(3-(R)-Aminopiperidin-1-yl)-5-(3-hydroxyprop-1-ynyl)-6-oxo-6H-pyrimidin-1-ylmethyl]benzonitrile	Investigative	11360493	C20H21N5O2	363.4	C1C[C@H](CN(C1)C2=NC=C(C(=O)N2CC3=CC=CC=C3C#N)C#CCO)N	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	BNS3C1	(2S,3S)-2-Amino-1-[(3S)-3-fluoropyrrolidin-1-yl]-3-(4-methylsulfanylphenyl)butan-1-one;2,2,2-trifluoroacetic acid	Investigative	49797056	C17H22F4N2O3S	410.4	C[C@@H](C1=CC=C(C=C1)SC)[C@@H](C(=O)N2CC[C@@H](C2)F)N.C(=O)(C(F)(F)F)O	IC50 = 61000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	BNU6E3	(2S,3S)-2-Amino-3-[3-(2-fluorophenyl)-1,2,4-oxadiazol-5-yl]-1-(pyrrolidin-1-yl)butan-1-one	Investigative	23645689	C16H19FN4O2	318.35	C[C@H](C1=NC(=NO1)C2=CC=CC=C2F)[C@@H](C(=O)N3CCCC3)N	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	BNV4S9	US9051329, Example 8	Investigative	71203746	C22H23F4N7O2	493.5	CCN1C(=O)CN2C1=NC3=C(C2=O)N(C(=N3)N4CCC[C@H](C4)N)CC5=C(C=CC(=C5)F)C(F)(F)F	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	BNX0V1	N-[(2R,3R)-2-Amino-3-(2,4,5-trifluorophenyl)-1,2,3,4-tetrahydropyrido[1,2-a]benzimidazol-7-yl]methanesulfonamide;2,2,2-trifluoroacetic acid	Investigative	49797607	C20H18F6N4O4S	524.4	CS(=O)(=O)NC1=CC2=C(C=C1)N3C[C@@H]([C@H](CC3=N2)C4=CC(=C(C=C4F)F)F)N.C(=O)(C(F)(F)F)O	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	BNXL30	(2S,3S)-2-Amino-3-[3-(2-chloro-4-methylsulfonylphenyl)-1,2,4-oxadiazol-5-yl]-1-[(3S)-3-fluoropyrrolidin-1-yl]butan-1-one;2,2,2-trifluoroacetic acid	Investigative	49797194	C19H21ClF4N4O6S	544.9	C[C@H](C1=NC(=NO1)C2=C(C=C(C=C2)S(=O)(=O)C)Cl)[C@@H](C(=O)N3CC[C@@H](C3)F)N.C(=O)(C(F)(F)F)O	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	BNZ7Y3	(3R)-3-Amino-4-(2,5-difluorophenyl)-1-[2-methyl-3-(trifluoromethyl)-2H,4H,5H,6H,7H-pyrazolo[3,4-c]pyridin-6-yl]butan-1-one	Investigative	23645935	C18H19F5N4O	402.4	CN1C(=C2CCN(CC2=N1)C(=O)C[C@@H](CC3=C(C=CC(=C3)F)F)N)C(F)(F)F	IC50 = 65000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	BO0T5X	(2S,3S)-2-Amino-1-[(3S)-3-fluoropyrrolidin-1-yl]-3-(4-methylsulfonylphenyl)butan-1-one;2,2,2-trifluoroacetic acid	Investigative	49797055	C17H22F4N2O5S	442.4	C[C@@H](C1=CC=C(C=C1)S(=O)(=O)C)[C@@H](C(=O)N2CC[C@@H](C2)F)N.C(=O)(C(F)(F)F)O	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	BO24TP	(3R)-3-Amino-4-(2,5-difluorophenyl)-1-[1-(2,2,2-trifluoroethyl)-3-(trifluoromethyl)-1H,4H,5H,6H,7H-pyrazolo[4,3-c]pyridin-5-yl]butan-1-one	Investigative	23645921	C19H18F8N4O	470.4	C1CN(CC2=C1N(N=C2C(F)(F)F)CC(F)(F)F)C(=O)C[C@@H](CC3=C(C=CC(=C3)F)F)N	IC50 = 71000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	BO34KM	(2R,3S,5R)-2-(2,5-Difluorophenyl)-5-(2-methyl-4,6-dihydropyrrolo[3,4-d][1,3]oxazol-5-yl)oxan-3-amine	Investigative	73355285	C17H19F2N3O2	335.35	CC1=NC2=C(O1)CN(C2)[C@@H]3C[C@@H]([C@H](OC3)C4=C(C=CC(=C4)F)F)N	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	BO3K8F	(2s,4s)-1-({(2s,4s)-4-[2-(1,3-Dihydro-2h-isoindol-2-yl)-2-oxoethyl]-5-oxopyrrolidin-2-yl}carbonyl)-4-fluoropyrrolidine-2-carbonitrile	Investigative	46917047	C20H21FN4O3	384.4	C1[C@@H](CN([C@@H]1C#N)C(=O)[C@@H]2C[C@H](C(=O)N2)CC(=O)N3CC4=CC=CC=C4C3)F	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	BO45VH	(3R,4R)-1-([1,2,4]Triazolo[4,3-b]pyridazin-6-yl)-4-(2,4,5-trifluorophenyl)piperidin-3-amine;2,2,2-trifluoroacetic acid	Investigative	49797250	C18H16F6N6O2	462.3	C1CN(C[C@@H]([C@H]1C2=CC(=C(C=C2F)F)F)N)C3=NN4C=NN=C4C=C3.C(=O)(C(F)(F)F)O	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	BO75ZR	(2S,3S)-2-Amino-3-[3-(2-chloro-4-methylsulfonylphenyl)-1,2,4-oxadiazol-5-yl]-4-cyclopropyl-1-[(3S)-3-fluoropyrrolidin-1-yl]butan-1-one;2,2,2-trifluoroacetic acid	Investigative	49797195	C22H25ClF4N4O6S	585	CS(=O)(=O)C1=CC(=C(C=C1)C2=NOC(=N2)[C@@H](CC3CC3)[C@@H](C(=O)N4CC[C@@H](C4)F)N)Cl.C(=O)(C(F)(F)F)O	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	BO7A3J	4-(Aminomethyl)-5-(2-chlorophenyl)-3-methyl-1H-benzimidazol-2-one	Investigative	11529375	C15H14ClN3O	287.74	CN1C2=C(C=CC(=C2CN)C3=CC=CC=C3Cl)NC1=O	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	BO7R2A	4-[(3R,5S,6R)-5-Amino-6-(2,4,5-trifluorophenyl)oxan-3-yl]-11-methyl-4,7,8,12-tetrazatricyclo[6.4.0.02,6]dodeca-1(12),2(6),10-trien-9-one	Investigative	127049507	C20H20F3N5O2	419.4	CC1=CC(=O)N2C(=N1)C3=C(N2)CN(C3)[C@@H]4C[C@@H]([C@H](OC4)C5=CC(=C(C=C5F)F)F)N	IC50 = 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	BOB84S	(2R,3S,5R)-2-(2,5-Difluorophenyl)-5-(2-ethylsulfonyl-4,6-dihydropyrrolo[3,4-c]pyrazol-5-yl)oxan-3-amine	Investigative	127035240	C18H22F2N4O3S	412.5	CCS(=O)(=O)N1C=C2CN(CC2=N1)[C@@H]3C[C@@H]([C@H](OC3)C4=C(C=CC(=C4)F)F)N	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	BOC90L	(2S,4S)-4-(4-Chlorobenzylamino)-2-amino-5-phenyl-1-(piperidin-1-yl)pentan-1-one	Investigative	44415930	C23H30ClN3O	400	C1CCN(CC1)C(=O)[C@H](C[C@H](CC2=CC=CC=C2)NCC3=CC=C(C=C3)Cl)N	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	BOMJ65	2-[4-[Amino-[2-[(4R)-4-cyano-1,3-thiazolidin-3-yl]-2-oxoethyl]amino]piperidin-1-yl]-N-(5-chloropyridin-2-yl)acetamide;trihydrochloride	Investigative	90664925	C18H27Cl4N7O2S	547.3	C1CN(CCC1N(CC(=O)N2CSC[C@H]2C#N)N)CC(=O)NC3=NC=C(C=C3)Cl.Cl.Cl.Cl	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	BOY06Z	N-[4-[(1R)-1-Amino-2-(2,5-difluorophenyl)ethyl]cyclohexyl]-N-methylpyridine-3-carboxamide	Investigative	53324145	C21H25F2N3O	373.4	CN(C1CCC(CC1)[C@@H](CC2=C(C=CC(=C2)F)F)N)C(=O)C3=CN=CC=C3	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	BP27EJ	2-[(3R)-4-[(3R)-3-Amino-4-(2,5-difluorophenyl)butanoyl]-3-methyl-2-oxo-1,4-diazepan-1-yl]acetic acid	Investigative	23647116	C18H23F2N3O4	383.4	C[C@@H]1C(=O)N(CCCN1C(=O)C[C@@H](CC2=C(C=CC(=C2)F)F)N)CC(=O)O	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	BP37WX	Chembl4205581	Investigative	145978547	C19H19ClN6	366.8	C1C[C@H](CN(C1)C2=C(C(=NC3=CC=NN32)Cl)CC4=CC=CC=C4C#N)N	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	BP4E3S	(2S,3S)-2-Amino-3-(3-fluoro-4-phenylphenyl)-1-[(3S)-3-fluoropyrrolidin-1-yl]butan-1-one;2,2,2-trifluoroacetic acid	Investigative	49797045	C22H23F5N2O3	458.4	C[C@@H](C1=CC(=C(C=C1)C2=CC=CC=C2)F)[C@@H](C(=O)N3CC[C@@H](C3)F)N.C(=O)(C(F)(F)F)O	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	BP4K9O	6-[(3R)-3-Aminopiperidin-1-yl]-1-[(2-bromophenyl)methyl]pyrimidine-2,4-dione	Investigative	11291901	C16H19BrN4O2	379.25	C1C[C@H](CN(C1)C2=CC(=O)NC(=O)N2CC3=CC=CC=C3Br)N	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	BP4L3F	(3R)-4-[(3R)-3-Amino-4-(2,4,5-trifluorophenyl)butanoyl]-1,3-dimethyl-1,4-diazepan-2-one	Investigative	23647118	C17H22F3N3O2	357.37	C[C@@H]1C(=O)N(CCCN1C(=O)C[C@@H](CC2=CC(=C(C=C2F)F)F)N)C	IC50 = 58000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	BP6I9S	CID 16035093	Investigative	16035093	C13H22N4O2	266.34	CCN(CC#N)C(=O)[C@@H]1C[C@@H]([C@@H](N1)C)C(=O)N(C)C	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	BPAF38	(R)-3-Amino-1-(3-cyclopropyl-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)-4-(2,4,5-trifluorophenyl)butan-1-one	Investigative	44431218	C18H20F3N5O	379.4	C1CC1C2=NN=C3N2CCN(C3)C(=O)C[C@@H](CC4=CC(=C(C=C4F)F)F)N	IC50 = 54000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	BPL02K	(3R)-3-Amino-1-(4-benzyl-1-methyl-2-(trifluoromethyl)-6,7-dihydro-1H-imidazo[4,5-c]pyridin-5(4H)-yl)-4-(2,4,5-trifluorophenyl)butan-1-one	Investigative	10255762	C25H24F6N4O	510.5	CN1C2=C(C(N(CC2)C(=O)C[C@@H](CC3=CC(=C(C=C3F)F)F)N)CC4=CC=CC=C4)N=C1C(F)(F)F	IC50 = 70000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	BPN96G	(2S,3S)-2-Amino-3-{3-[2-(difluoromethyl)phenyl]-1,2,4-oxadiazol-5-yl}-1-(pyrrolidin-1-yl)butan-1-one	Investigative	23645687	C17H20F2N4O2	350.36	C[C@H](C1=NC(=NO1)C2=CC=CC=C2C(F)F)[C@@H](C(=O)N3CCCC3)N	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	BPNR09	(2S)-1-(2-{[2-Methyl-4-oxo-4-(1,2,3,4-tetrahydroisoquinolin-2-yl)butan-2-yl]amino}acetyl)pyrrolidine-2-carbonitrile	Investigative	11581458	C21H28N4O2	368.5	CC(C)(CC(=O)N1CCC2=CC=CC=C2C1)NCC(=O)N3CCC[C@H]3C#N	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	BPO3Y7	(3R,6R)-4-[(3R)-3-Amino-4-(2,4,5-trifluorophenyl)butanoyl]-3-ethyl-6-methyl-1,4-diazepan-2-one	Investigative	23647126	C18H24F3N3O2	371.4	CC[C@@H]1C(=O)NC[C@H](CN1C(=O)C[C@@H](CC2=CC(=C(C=C2F)F)F)N)C	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	BPQ2K7	4-[(3R)-3-Amino-4-(2,4,5-trifluorophenyl)butanoyl]-5-methyl-1,4-diazepan-2-one	Investigative	21045424	C16H20F3N3O2	343.34	CC1CCNC(=O)CN1C(=O)C[C@@H](CC2=CC(=C(C=C2F)F)F)N	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	BPS40F	(2R,3R)-3-(3-(2-Chloro-4-(methylsulfonyl)phenyl)-1,2,4-oxadiazol-5-yl)-1-(2,4,5-trifluorophenyl)butan-2-amine	Investigative	44561155	C19H17ClF3N3O3S	459.9	C[C@@H](C1=NC(=NO1)C2=C(C=C(C=C2)S(=O)(=O)C)Cl)[C@@H](CC3=CC(=C(C=C3F)F)F)N	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	BPS6R2	(2S,3S)-3-Amino-4-[(3S)-3-fluoropyrrolidin-1-yl]-2-(4-imidazo[1,2-b]pyridazin-6-ylphenyl)-N,N-dimethyl-4-oxobutanamide;2,2,2-trifluoroacetic acid	Investigative	11533932	C24H26F4N6O4	538.5	CN(C)C(=O)[C@@H](C1=CC=C(C=C1)C2=NN3C=CN=C3C=C2)[C@@H](C(=O)N4CC[C@@H](C4)F)N.C(=O)(C(F)(F)F)O	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	BQ1T2X	(2S,3S)-2-Amino-1-(pyrrolidin-1-yl)-3-{3-[2-(trifluoromethyl)phenyl]-1,2,4-oxadiazol-5-yl}butan-1-one	Investigative	23645690	C17H19F3N4O2	368.35	C[C@H](C1=NC(=NO1)C2=CC=CC=C2C(F)(F)F)[C@@H](C(=O)N3CCCC3)N	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	BQ3V5R	[5-(2,4-Dichlorophenyl)-3-ethylbenzimidazol-4-yl]methanamine	Investigative	11631125	C16H15Cl2N3	320.2	CCN1C=NC2=C1C(=C(C=C2)C3=C(C=C(C=C3)Cl)Cl)CN	IC50 = 50000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	BQ4WR0	N-[4-[(2S,3S)-3-Amino-4-[(3S)-3-fluoropyrrolidin-1-yl]-4-oxobutan-2-yl]phenyl]-N-methylacetamide;2,2,2-trifluoroacetic acid	Investigative	49797352	C19H25F4N3O4	435.4	C[C@@H](C1=CC=C(C=C1)N(C)C(=O)C)[C@@H](C(=O)N2CC[C@@H](C2)F)N.C(=O)(C(F)(F)F)O	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	BQ5I2G	CID 53311226	Investigative	53311226	C22H26N6O	390.5	CC(C)N1C2=NC=CC(=C2N(C1=O)CC3=CC=CC=C3C#N)N4CCC[C@H](C4)N	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	BQ7KD9	(2S,3S)-2-Amino-3-(4-chlorophenyl)-1-[(3S)-3-fluoropyrrolidin-1-yl]butan-1-one;2,2,2-trifluoroacetic acid	Investigative	49797042	C16H19ClF4N2O3	398.78	C[C@@H](C1=CC=C(C=C1)Cl)[C@@H](C(=O)N2CC[C@@H](C2)F)N.C(=O)(C(F)(F)F)O	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	BQ7M5N	(2S)-1-[(2S,4S)-4-[2-(3,4-Dihydro-1H-isoquinolin-2-yl)-2-oxoethyl]-5-oxopyrrolidine-2-carbonyl]pyrrolidine-2-carbonitrile	Investigative	46938705	C21H24N4O3	380.4	C1C[C@H](N(C1)C(=O)[C@@H]2C[C@H](C(=O)N2)CC(=O)N3CCC4=CC=CC=C4C3)C#N	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	BQ8B6M	N-[3-[4-[(2S,3S)-3-Amino-4-[(3S)-3-fluoropyrrolidin-1-yl]-4-oxobutan-2-yl]phenyl]phenyl]methanesulfonamide;2,2,2-trifluoroacetic acid	Investigative	49797094	C23H27F4N3O5S	533.5	C[C@@H](C1=CC=C(C=C1)C2=CC(=CC=C2)NS(=O)(=O)C)[C@@H](C(=O)N3CC[C@@H](C3)F)N.C(=O)(C(F)(F)F)O	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	BQ94KU	(2S)-1-[{(2S,4S)-5-Oxo-4-(2-oxo-2-(piperidin-1-yl)ethyl)pyrrolidine-2-yl}carbonyl]pyrrolidine-2-carbonitrile	Investigative	46938799	C17H24N4O3	332.4	C1CCN(CC1)C(=O)C[C@@H]2C[C@H](NC2=O)C(=O)N3CCC[C@H]3C#N	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	BQF2I5	CID 53311144	Investigative	53311144	C22H25N5O	375.5	CC1(C2=NC=CC(=C2N(C1=O)CC3=CC=CC=C3C#N)N4CCC[C@H](C4)N)C	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	BQK9T2	(2S)-1-[(2S,4S)-4-[2-(5-Fluoro-1,3-dihydroisoindol-2-yl)-2-oxoethyl]-5-oxopyrrolidine-2-carbonyl]pyrrolidine-2-carbonitrile	Investigative	46916389	C20H21FN4O3	384.4	C1C[C@H](N(C1)C(=O)[C@@H]2C[C@H](C(=O)N2)CC(=O)N3CC4=C(C3)C=C(C=C4)F)C#N	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	BR8GC9	Ethyl N-[5-[4-[(2S,3S)-3-amino-4-[(3S)-3-fluoropyrrolidin-1-yl]-4-oxobutan-2-yl]phenyl]-3-fluoro-1-methyl-2-oxopyridin-4-yl]carbamate;2,2,2-trifluoroacetic acid	Investigative	49797120	C25H29F5N4O6	576.5	CCOC(=O)NC1=C(C(=O)N(C=C1C2=CC=C(C=C2)[C@H](C)[C@@H](C(=O)N3CC[C@@H](C3)F)N)C)F.C(=O)(C(F)(F)F)O	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	BRF0W5	3,4-Dihydro-1H-isoquinolin-2-yl-[(2S)-pyrrolidin-2-yl]methanone	Investigative	22691359	C14H18N2O	230.31	C1C[C@H](NC1)C(=O)N2CCC3=CC=CC=C3C2	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	BRF68C	(R)-3-Amino-1-(3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)-4-(4-(trifluoromethyl)phenyl)butan-1-one	Investigative	44431197	C17H17F6N5O	421.34	C1CN2C(=NN=C2C(F)(F)F)CN1C(=O)C[C@@H](CC3=CC=C(C=C3)C(F)(F)F)N	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	BRFD05	6-(4-{(1S,2S)-2-Amino-1-[(dimethylamino)carbonyl]-3-[(3S)-3-fluoropyrrolidin-1-YL]-3-oxopropyl}phenyl)-1H-[1,2,4]triazolo[1,5-A]pyridin-4-ium	Investigative	10320144	C22H25FN6O2	424.5	CN(C)C(=O)[C@@H](C1=CC=C(C=C1)C2=CN3C(=NC=N3)C=C2)[C@@H](C(=O)N4CC[C@@H](C4)F)N	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	BRFO98	N-[4-[(1R)-1-Amino-2-(2,5-difluorophenyl)ethyl]cyclohexyl]-3-cyano-N-methylbenzenesulfonamide	Investigative	53317564	C22H25F2N3O2S	433.5	CN(C1CCC(CC1)[C@@H](CC2=C(C=CC(=C2)F)F)N)S(=O)(=O)C3=CC=CC(=C3)C#N	IC50 ~ 69000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	BRI61C	(3R)-3-Amino-1-(6,8-dihydro-5H-[1,2,4]triazolo[4,3-a]pyrazin-7-yl)-4-(2,4,5-trifluorophenyl)butan-1-one;hydrochloride	Investigative	23645411	C15H17ClF3N5O	375.77	C1CN2C=NN=C2CN1C(=O)C[C@@H](CC3=CC(=C(C=C3F)F)F)N.Cl	IC50 = 72000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	BRJ89X	3-(4-((R)-1-Amino-2-(2,5-difluorophenyl)ethyl)piperidin-1-yl)cyclohexanecarboxamide	Investigative	53322826	C20H29F2N3O	365.5	C1CC(CC(C1)N2CCC(CC2)[C@@H](CC3=C(C=CC(=C3)F)F)N)C(=O)N	IC50 = 58000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	BRN8T6	5-[4-[(2S,3S)-3-Amino-4-[(3S)-3-fluoropyrrolidin-1-yl]-4-oxobutan-2-yl]phenyl]-3-bromo-1-methylpyridin-2-one;2,2,2-trifluoroacetic acid	Investigative	49797123	C22H24BrF4N3O4	550.3	C[C@@H](C1=CC=C(C=C1)C2=CN(C(=O)C(=C2)Br)C)[C@@H](C(=O)N3CC[C@@H](C3)F)N.C(=O)(C(F)(F)F)O	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	BRT85J	Pyrrolidine, 1-(N-phenylalanyl)-	Investigative	7020797	C13H18N2O	218.29	C1CCN(C1)C(=O)[C@H](CC2=CC=CC=C2)N	IC50 = 115000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	BRX26E	(3R,7R)-4-[(3R)-3-Amino-4-(2,4,5-trifluorophenyl)butanoyl]-3,7-dimethyl-1,4-diazepan-2-one	Investigative	11417008	C17H22F3N3O2	357.37	C[C@@H]1CCN([C@@H](C(=O)N1)C)C(=O)C[C@@H](CC2=CC(=C(C=C2F)F)F)N	IC50 = 58000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	BS09KC	4-[(3R)-3-Amino-4-(2,5-difluorophenyl)butanoyl]-3-methyl-1,4-diazepan-2-one	Investigative	10426457	C16H21F2N3O2	325.35	CC1C(=O)NCCCN1C(=O)C[C@@H](CC2=C(C=CC(=C2)F)F)N	IC50 = 58000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	BS2MI3	(2S,3S)-3-Amino-4-(3,3-difluoropyrrolidin-1-yl)-2-((1r,4S)-4-(4-fluorophenyl)cyclohexyl)-N,N-dimethyl-4-oxobutanamide	Investigative	11676224	C22H30F3N3O2	425.5	CN(C)C(=O)[C@@H](C1CCC(CC1)C2=CC=C(C=C2)F)[C@@H](C(=O)N3CCC(C3)(F)F)N	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	BS38NJ	4-[(1R)-1-Amino-2-(2,5-difluorophenyl)ethyl]-N-(4,4,4-trifluorobutyl)cyclohexan-1-amine	Investigative	53324154	C18H25F5N2	364.4	C1CC(CCC1[C@@H](CC2=C(C=CC(=C2)F)F)N)NCCCC(F)(F)F	IC50 = 75000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	BS3NO2	(2S,3S)-2-Amino-1-(pyrrolidin-1-yl)-3-{3-[3-(trifluoromethyl)phenyl]-1,2,4-oxadiazol-5-yl}butan-1-one	Investigative	23645692	C17H19F3N4O2	368.35	C[C@H](C1=NC(=NO1)C2=CC(=CC=C2)C(F)(F)F)[C@@H](C(=O)N3CCCC3)N	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	BS4JE3	4-[(3R)-3-Amino-4-(2,4,5-trifluorophenyl)butanoyl]-1,4-diazepan-2-one	Investigative	23646448	C15H18F3N3O2	329.32	C1CNC(=O)CN(C1)C(=O)C[C@@H](CC2=CC(=C(C=C2F)F)F)N	IC50 = 82000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	BS74NP	(5-(Aminomethyl)-4-(4-fluorophenyl)-6-methylpyridin-2-yl)(pyrrolidin-1-yl)methanone	Investigative	51356958	C18H20FN3O	313.4	CC1=C(C(=CC(=N1)C(=O)N2CCCC2)C3=CC=C(C=C3)F)CN	Ki = 137000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	BS94PE	Chembl4204176	Investigative	145975568	C18H18N6O	334.4	C1CN(CCN1)C2=CC(=O)N3C(=CC=N3)N2CC4=CC=CC=C4C#N	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	BSAY01	(2R,3S,5R)-2-(4-Chloro-2,5-difluorophenyl)-5-(4,6-dihydro-1H-pyrrolo[3,4-c]pyrazol-5-yl)oxan-3-amine	Investigative	73346173	C16H17ClF2N4O	354.78	C1[C@H](CO[C@@H]([C@H]1N)C2=CC(=C(C=C2F)Cl)F)N3CC4=C(C3)NN=C4	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	BSJ8D4	N-[(2R,3R)-2-Amino-3-(2,4,5-trifluorophenyl)-1,2,3,4-tetrahydropyrido[1,2-a]benzimidazol-7-yl]acetamide;2,2,2-trifluoroacetic acid	Investigative	49797650	C21H18F6N4O3	488.4	CC(=O)NC1=CC2=C(C=C1)N3C[C@@H]([C@H](CC3=N2)C4=CC(=C(C=C4F)F)F)N.C(=O)(C(F)(F)F)O	IC50 = 53000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	BSN76O	2-[2-(3-(r)-Aminopiperidin-1-yl)-5-chloro-6-oxo-6h-pyrimidin-1-ylmethyl]benzonitrile	Investigative	11439333	C17H18ClN5O	343.8	C1C[C@H](CN(C1)C2=NC=C(C(=O)N2CC3=CC=CC=C3C#N)Cl)N	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	BSP3F8	(3R)-3-Amino-1-[(5S,8S)-5,8-dimethyl-3-(trifluoromethyl)-6,8-dihydro-5H-[1,2,4]triazolo[4,3-a]pyrazin-7-yl]-4-(2,4,5-trifluorophenyl)butan-1-one;hydrochloride	Investigative	24777439	C18H20ClF6N5O	471.8	C[C@H]1CN([C@H](C2=NN=C(N12)C(F)(F)F)C)C(=O)C[C@@H](CC3=CC(=C(C=C3F)F)F)N.Cl	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	BSPH26	(S)-3-(2-(2-Cyanopyrrolidin-1-yl)-2-oxoethylamino)-N-(3,4-dimethoxyphenyl)-3-methylbutanamide	Investigative	11596219	C20H28N4O4	388.5	CC(C)(CC(=O)NC1=CC(=C(C=C1)OC)OC)NCC(=O)N2CCC[C@H]2C#N	IC50 ~ 50000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	BSUJ28	(2R,3S,5R)-2-(2,5-Difluorophenyl)-5-(3-methylsulfonyl-4,6-dihydro-1H-pyrrolo[3,4-c]pyrazol-5-yl)oxan-3-amine	Investigative	127035752	C17H20F2N4O3S	398.4	CS(=O)(=O)C1=NNC2=C1CN(C2)[C@@H]3C[C@@H]([C@H](OC3)C4=C(C=CC(=C4)F)F)N	IC50 = 60000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	BSUR86	(2s,3s)-3-Amino-4-(3,3-Difluoropyrrolidin-1-Yl)-N,N-Dimethyl-4-Oxo-2-(trans-4-[1,2,4]triazolo[1,5-A]pyridin-6-Ylcyclohexyl)butanamide	Investigative	11554165	C22H30F2N6O2	448.5	CN(C)C(=O)[C@@H](C1CCC(CC1)C2=CN3C(=NC=N3)C=C2)[C@@H](C(=O)N4CCC(C4)(F)F)N	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	BT2J1C	2-[(3-Methyl-2-oxo-7-piperazin-1-ylimidazo[4,5-b]pyridin-1-yl)methyl]benzonitrile	Investigative	53312323	C19H20N6O	348.4	CN1C2=NC=CC(=C2N(C1=O)CC3=CC=CC=C3C#N)N4CCNCC4	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	BT41RH	(2s)-1-({(2s,4s)-4-[2-[4-(Pyridine-4-yl)-piperazin-1-yl]-2-oxoethyl]-5-oxopyrrolidin-2-yl}carbonyl)pyrrolidine-2-carbonitrile	Investigative	46916347	C21H26N6O3	410.5	C1C[C@H](N(C1)C(=O)[C@@H]2C[C@H](C(=O)N2)CC(=O)N3CCN(CC3)C4=CC=NC=C4)C#N	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	BT5CH8	[3-Methyl-5-(2-methylphenyl)benzimidazol-4-yl]methanamine	Investigative	11680394	C16H17N3	251.33	CC1=CC=CC=C1C2=C(C3=C(C=C2)N=CN3C)CN	IC50 = 80000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	BT82FY	2-(S)-Amino-4-(2-chloro-benzylamino)-1-piperidin-1-yl-butan-1-one	Investigative	11232123	C16H24ClN3O	309.83	C1CCN(CC1)C(=O)[C@H](CCNCC2=CC=CC=C2Cl)N	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	BT8HB5	(2S,3S)-2-Amino-1-[(3S)-3-fluoropyrrolidin-1-yl]-3-(4-pyridin-4-ylphenyl)butan-1-one;2,2,2-trifluoroacetic acid	Investigative	49797072	C21H23F4N3O3	441.4	C[C@@H](C1=CC=C(C=C1)C2=CC=NC=C2)[C@@H](C(=O)N3CC[C@@H](C3)F)N.C(=O)(C(F)(F)F)O	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	BT94PM	(2S)-2-Amino-2-phenyl-1-(1,2,3,4-tetrahydroisoquinolin-2-yl)ethan-1-one	Investigative	22691666	C17H18N2O	266.34	C1CN(CC2=CC=CC=C21)C(=O)[C@H](C3=CC=CC=C3)N	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	BT97SU	(3R)-3-Amino-1-[(8S)-8-methyl-3-(trifluoromethyl)-6,8-dihydro-5H-[1,2,4]triazolo[4,3-a]pyrazin-7-yl]-4-(2,4,5-trifluorophenyl)butan-1-one;hydrochloride	Investigative	24777691	C17H18ClF6N5O	457.8	C[C@H]1C2=NN=C(N2CCN1C(=O)C[C@@H](CC3=CC(=C(C=C3F)F)F)N)C(F)(F)F.Cl	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	BTC89V	2,2,2-Trifluoroacetic acid;(3R,4R)-1-[4-(trifluoromethyl)pyridin-2-yl]-4-(2,4,5-trifluorophenyl)piperidin-3-amine	Investigative	49797229	C19H16F9N3O2	489.3	C1CN(C[C@@H]([C@H]1C2=CC(=C(C=C2F)F)F)N)C3=NC=CC(=C3)C(F)(F)F.C(=O)(C(F)(F)F)O	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	BTD5R8	5-[4-[(2S,3S)-3-Amino-4-[(3S)-3-fluoropyrrolidin-1-yl]-4-oxobutan-2-yl]phenyl]-1-(4-fluorophenyl)pyridin-2-one;2,2,2-trifluoroacetic acid	Investigative	49797126	C27H26F5N3O4	551.5	C[C@@H](C1=CC=C(C=C1)C2=CN(C(=O)C=C2)C3=CC=C(C=C3)F)[C@@H](C(=O)N4CC[C@@H](C4)F)N.C(=O)(C(F)(F)F)O	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	BTK9S0	2-[5-(Aminomethyl)-6-(2,2-dimethylpropyl)-2-methyl-4-(4-methylphenyl)pyridin-3-yl]acetic acid;dihydrochloride	Investigative	51051331	C21H30Cl2N2O2	413.4	CC1=CC=C(C=C1)C2=C(C(=NC(=C2CC(=O)O)C)CC(C)(C)C)CN.Cl.Cl	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	BTKM76	(2S,3S)-2-Amino-1-[(3S)-3-fluoropyrrolidin-1-yl]-3-(4-pyridin-2-ylphenyl)butan-1-one;2,2,2-trifluoroacetic acid	Investigative	49797062	C21H23F4N3O3	441.4	C[C@@H](C1=CC=C(C=C1)C2=CC=CC=N2)[C@@H](C(=O)N3CC[C@@H](C3)F)N.C(=O)(C(F)(F)F)O	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	BTN0W1	N-[4-[(2S,3S)-3-Amino-1-(dimethylamino)-4-[(3S)-3-fluoropyrrolidin-1-yl]-1,4-dioxobutan-2-yl]phenyl]-N,4-dimethylbenzamide;2,2,2-trifluoroacetic acid	Investigative	49797346	C27H32F4N4O5	568.6	CC1=CC=C(C=C1)C(=O)N(C)C2=CC=C(C=C2)[C@@H]([C@@H](C(=O)N3CC[C@@H](C3)F)N)C(=O)N(C)C.C(=O)(C(F)(F)F)O	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	BTYI62	5-[4-[(2S,3S)-3-Amino-4-[(3S)-3-fluoropyrrolidin-1-yl]-4-oxobutan-2-yl]phenyl]-1-methylpyridin-2-one;2,2,2-trifluoroacetic acid	Investigative	49797115	C22H25F4N3O4	471.4	C[C@@H](C1=CC=C(C=C1)C2=CN(C(=O)C=C2)C)[C@@H](C(=O)N3CC[C@@H](C3)F)N.C(=O)(C(F)(F)F)O	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	BTYU35	(3R)-3-Amino-1-(1,4-dimethyl-2-(trifluoromethyl)-6,7-dihydro-1H-imidazo[4,5-c]pyridin-5(4H)-yl)-4-(2,4,5-trifluorophenyl)butan-1-one	Investigative	10433039	C19H20F6N4O	434.4	CC1C2=C(CCN1C(=O)C[C@@H](CC3=CC(=C(C=C3F)F)F)N)N(C(=N2)C(F)(F)F)C	IC50 = 58000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	BU1R5L	N-[5-[(3R,5S,6R)-5-Amino-6-(2,5-difluorophenyl)oxan-3-yl]-4,6-dihydro-1H-pyrrolo[3,4-c]pyrazol-3-yl]methanesulfonamide	Investigative	127035741	C17H21F2N5O3S	413.4	CS(=O)(=O)NC1=NNC2=C1CN(C2)[C@@H]3C[C@@H]([C@H](OC3)C4=C(C=CC(=C4)F)F)N	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	BU1VT2	(2S,3S)-3-Amino-4-[(3S)-3-fluoropyrrolidin-1-yl]-N,N-dimethyl-2-[4-(1-methyl-6-oxopyridin-3-yl)phenyl]-4-oxobutanamide;2,2,2-trifluoroacetic acid	Investigative	11577331	C24H28F4N4O5	528.5	CN1C=C(C=CC1=O)C2=CC=C(C=C2)[C@@H]([C@@H](C(=O)N3CC[C@@H](C3)F)N)C(=O)N(C)C.C(=O)(C(F)(F)F)O	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	BU3ZH9	(3R,7S)-4-[(3R)-3-Amino-4-(2,4,5-trifluorophenyl)butanoyl]-3-methyl-7-(trifluoromethyl)-1,4-diazepan-2-one	Investigative	44426070	C17H19F6N3O2	411.34	C[C@@H]1C(=O)N[C@@H](CCN1C(=O)C[C@@H](CC2=CC(=C(C=C2F)F)F)N)C(F)(F)F	IC50 = 76000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	BU5SB3	CID 16035094	Investigative	16035094	C12H20N4O2	252.31	C[C@H]1[C@H](C[C@H](N1)C(=O)N(C)CC#N)C(=O)N(C)C	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	BU69XW	(2S,3S)-2-Amino-1-[(3S)-3-fluoropyrrolidin-1-yl]-3-[4-(pyrazol-2-ium-1-carbonyl)phenyl]butan-1-one;2,2,2-trifluoroacetate	Investigative	45266134	C20H22F4N4O4	458.4	C[C@@H](C1=CC=C(C=C1)C(=O)N2C=CC=[NH+]2)[C@@H](C(=O)N3CC[C@@H](C3)F)N.C(=O)(C(F)(F)F)[O-]	IC50 = 63000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	BU6NL8	N-[5-[(3R,5S,6R)-5-Amino-6-(2,5-difluorophenyl)oxan-3-yl]-4,6-dihydro-1H-pyrrolo[3,4-c]pyrazol-3-yl]-1-pyridin-4-ylmethanesulfonamide	Investigative	127035745	C22H24F2N6O3S	490.5	C1[C@H](CO[C@@H]([C@H]1N)C2=C(C=CC(=C2)F)F)N3CC4=C(C3)NN=C4NS(=O)(=O)CC5=CC=NC=C5	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	BU7GI8	6-[(3R)-3-Aminopiperidin-1-yl]-1-but-2-ynyl-3-(quinolin-2-ylmethyl)pyrimidine-2,4-dione	Investigative	71731356	C23H25N5O2	403.5	CC#CCN1C(=CC(=O)N(C1=O)CC2=NC3=CC=CC=C3C=C2)N4CCC[C@H](C4)N	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	BU7V1J	(2S,3S)-2-[4-[Acetyl(methyl)amino]phenyl]-3-amino-4-[(3S)-3-fluoropyrrolidin-1-yl]-N,N-dimethyl-4-oxobutanamide;2,2,2-trifluoroacetic acid	Investigative	49797351	C21H28F4N4O5	492.5	CC(=O)N(C)C1=CC=C(C=C1)[C@@H]([C@@H](C(=O)N2CC[C@@H](C2)F)N)C(=O)N(C)C.C(=O)(C(F)(F)F)O	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	BU8OS2	(2R,3S,5R)-2-(2,5-Difluorophenyl)-5-(4,7,8,10,12-pentazatricyclo[6.4.0.02,6]dodeca-1,6,9,11-tetraen-4-yl)oxan-3-amine	Investigative	24952089	C18H18F2N6O	372.4	C1[C@H](CO[C@@H]([C@H]1N)C2=C(C=CC(=C2)F)F)N3CC4=C5N=CN=CN5N=C4C3	IC50 = 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	BUAE40	2-((2-(3-(R)-Aminopiperidin-1-yl)-5-chloro-6-oxopyrimidin-1(6H)-yl)methyl)-4-fluorobenzonitrile	Investigative	11451290	C17H17ClFN5O	361.8	C1C[C@H](CN(C1)C2=NC=C(C(=O)N2CC3=C(C=CC(=C3)F)C#N)Cl)N	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	BUCW67	N-[4-[(2S,3S)-3-Amino-4-[(3S)-3-fluoropyrrolidin-1-yl]-4-oxobutan-2-yl]phenyl]-4-fluoro-N-methylbenzamide;2,2,2-trifluoroacetic acid	Investigative	49797348	C24H26F5N3O4	515.5	C[C@@H](C1=CC=C(C=C1)N(C)C(=O)C2=CC=C(C=C2)F)[C@@H](C(=O)N3CC[C@@H](C3)F)N.C(=O)(C(F)(F)F)O	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	BUE26X	(3R)-3-Amino-1-[(8S)-8-[(4-fluorophenyl)methyl]-3-(trifluoromethyl)-6,8-dihydro-5H-[1,2,4]triazolo[4,3-a]pyrazin-7-yl]-4-(2,4,5-trifluorophenyl)butan-1-one;hydrochloride	Investigative	24776704	C23H21ClF7N5O	551.9	C1CN2C(=NN=C2C(F)(F)F)[C@@H](N1C(=O)C[C@@H](CC3=CC(=C(C=C3F)F)F)N)CC4=CC=C(C=C4)F.Cl	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	BUE29R	N-[5-[(3R,5S,6R)-5-Amino-6-(2,5-difluorophenyl)oxan-3-yl]-4,6-dihydro-1H-pyrrolo[3,4-c]pyrazol-3-yl]propanamide	Investigative	127035376	C19H23F2N5O2	391.4	CCC(=O)NC1=NNC2=C1CN(C2)[C@@H]3C[C@@H]([C@H](OC3)C4=C(C=CC(=C4)F)F)N	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	BUEI96	2-[[7-[(3R)-3-Aminopiperidin-1-yl]-3-methyl-2-sulfanylideneimidazo[4,5-b]pyridin-1-yl]methyl]benzonitrile	Investigative	53311074	C20H22N6S	378.5	CN1C2=NC=CC(=C2N(C1=S)CC3=CC=CC=C3C#N)N4CCC[C@H](C4)N	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	BUL31R	(2S,3S)-2-Amino-1-[(3S)-3-fluoropyrrolidin-1-yl]-3-(4-pyridin-3-ylphenyl)butan-1-one;2,2,2-trifluoroacetic acid	Investigative	49797073	C21H23F4N3O3	441.4	C[C@@H](C1=CC=C(C=C1)C2=CN=CC=C2)[C@@H](C(=O)N3CC[C@@H](C3)F)N.C(=O)(C(F)(F)F)O	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	BUMC70	2-({2-[(3r)-3-Aminopiperidin-1-Yl]-4-Oxoquinazolin-3(4h)-Yl}methyl)benzonitrile	Investigative	23647311	C21H21N5O	359.4	C1C[C@H](CN(C1)C2=NC3=CC=CC=C3C(=O)N2CC4=CC=CC=C4C#N)N	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	BUMZ62	(2S,3S)-2-Amino-1-[(3S)-3-fluoropyrrolidin-1-yl]-3-[4-[3-(1H-1,2,4-triazol-5-yl)phenyl]phenyl]butan-1-one;2,2,2-trifluoroacetic acid	Investigative	49797063	C24H25F4N5O3	507.5	C[C@@H](C1=CC=C(C=C1)C2=CC(=CC=C2)C3=NC=NN3)[C@@H](C(=O)N4CC[C@@H](C4)F)N.C(=O)(C(F)(F)F)O	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	BUP8W9	(R)-7-(3-Amino-4-(2,4,5-trifluorophenyl)butanoyl)-N-tert-butyl-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine-3-carboxamide	Investigative	10026124	C20H25F3N6O2	438.4	CC(C)(C)NC(=O)C1=NN=C2N1CCN(C2)C(=O)C[C@@H](CC3=CC(=C(C=C3F)F)F)N	IC50 = 63000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	BUQY47	(2R,3S,5R)-2-(2,5-Difluorophenyl)-5-(9-methyl-4,7,8,12-tetrazatricyclo[6.4.0.02,6]dodeca-1,6,9,11-tetraen-4-yl)oxan-3-amine	Investigative	127050762	C20H21F2N5O	385.4	CC1=CC=NC2=C3CN(CC3=NN12)[C@@H]4C[C@@H]([C@H](OC4)C5=C(C=CC(=C5)F)F)N	IC50 = 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	BUS09Q	(2S,3R,5S)-2-(2,5-Difluorophenyl)-5-(4,6-dihydro-1H-pyrrolo[3,4-c]pyrazol-5-yl)oxan-3-amine	Investigative	72193502	C16H18F2N4O	320.34	C1[C@@H](CO[C@H]([C@@H]1N)C2=C(C=CC(=C2)F)F)N3CC4=C(C3)NN=C4	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	BUTA70	2-[[2-[(3R)-3-Aminopiperidin-1-yl]-6-oxo-5-prop-1-ynylpyrimidin-1-yl]methyl]benzonitrile	Investigative	11256520	C20H21N5O	347.4	CC#CC1=CN=C(N(C1=O)CC2=CC=CC=C2C#N)N3CCC[C@H](C3)N	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	BUV27B	(2S,3S)-2-Amino-4-cyclopropyl-3-[3-(2-fluoro-4-methylsulfonylphenyl)-1,2,4-oxadiazol-5-yl]-1-[(3S)-3-fluoropyrrolidin-1-yl]butan-1-one;2,2,2-trifluoroacetic acid	Investigative	11527019	C22H25F5N4O6S	568.5	CS(=O)(=O)C1=CC(=C(C=C1)C2=NOC(=N2)[C@@H](CC3CC3)[C@@H](C(=O)N4CC[C@@H](C4)F)N)F.C(=O)(C(F)(F)F)O	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	BV2MF8	(R)-4-((R)-3-Amino-4-(2-fluorophenyl)butanoyl)-3-methyl-1,4-diazepan-2-one	Investigative	44561192	C16H22FN3O2	307.36	C[C@@H]1C(=O)NCCCN1C(=O)C[C@@H](CC2=CC=CC=C2F)N	IC50 = 87000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	BV2UR3	(2s)-1-({(2s,4s)-4-[2-(5-Chloro-1,3-dihydro-2h-isoindol-2-yl)-2-oxoethyl]-5-oxopyrrolidin-2-yl}carbonyl)pyrrolidine-2-carbonitrile	Investigative	46938704	C20H21ClN4O3	400.9	C1C[C@H](N(C1)C(=O)[C@@H]2C[C@H](C(=O)N2)CC(=O)N3CC4=C(C3)C=C(C=C4)Cl)C#N	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	BV3G9D	4-[[[(2S)-1-[3-Amino-4-(3,4-difluorophenyl)butanoyl]pyrrolidine-2-carbonyl]amino]methyl]benzoic acid;2,2,2-trifluoroacetic acid	Investigative	49796939	C25H26F5N3O6	559.5	C1C[C@H](N(C1)C(=O)CC(CC2=CC(=C(C=C2)F)F)N)C(=O)NCC3=CC=C(C=C3)C(=O)O.C(=O)(C(F)(F)F)O	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	BV3J9P	(2S,3S)-3-Amino-4-(3,3-difluoropyrrolidin-1-yl)-N,N-dimethyl-4-oxo-2-[4-([1,2,4]triazolo[1,5-a]pyridin-7-yl)phenyl]butanamide;2,2,2-trifluoroacetic acid	Investigative	11613750	C24H25F5N6O4	556.5	CN(C)C(=O)[C@@H](C1=CC=C(C=C1)C2=CC3=NC=NN3C=C2)[C@@H](C(=O)N4CCC(C4)(F)F)N.C(=O)(C(F)(F)F)O	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	BV56JW	2-[[9-[(3R)-3-Aminopiperidin-1-yl]-3-methyl-2-oxoimidazo[4,5-b]quinolin-1-yl]methyl]benzonitrile	Investigative	53311069	C24H24N6O	412.5	CN1C2=NC3=CC=CC=C3C(=C2N(C1=O)CC4=CC=CC=C4C#N)N5CCC[C@H](C5)N	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	BV7Q2F	(2R)-2-[4-[[[(2S)-1-[3-Amino-4-(2,3,4,5,6-pentafluorophenyl)butanoyl]pyrrolidine-2-carbonyl]amino]methyl]phenoxy]-3-methylbutanoic acid;2,2,2-trifluoroacetic acid	Investigative	49796955	C29H31F8N3O7	685.6	CC(C)[C@H](C(=O)O)OC1=CC=C(C=C1)CNC(=O)[C@@H]2CCCN2C(=O)CC(CC3=C(C(=C(C(=C3F)F)F)F)F)N.C(=O)(C(F)(F)F)O	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	BV8IR6	(R)-3-Amino-1-((S)-2-(5-(3-methyloxetan-3-yl)-1,2,4-oxadiazol-3-yl)pyrrolidin-1-yl)-4-(2,4,5-trifluorophenyl)butan-1-one	Investigative	45487917	C20H23F3N4O3	424.4	CC1(COC1)C2=NC(=NO2)[C@@H]3CCCN3C(=O)C[C@@H](CC4=CC(=C(C=C4F)F)F)N	IC50 = 72000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	BV9NG7	(2S,3As,6aS)-1-[(3R)-3-amino-4-(2-methylphenyl)butanoyl]-3,3a,4,5,6,6a-hexahydro-2H-cyclopenta[b]pyrrole-2-carbonitrile	Investigative	118712779	C19H25N3O	311.4	CC1=CC=CC=C1C[C@H](CC(=O)N2[C@H]3CCC[C@H]3C[C@H]2C#N)N	IC50 = 76720 nM	Poor binder
T15855	Dipeptidyl peptidase 8	BVD8U1	(2S,3S)-2-Amino-3-[4-(2-fluorophenyl)phenyl]-1-[(3S)-3-fluoropyrrolidin-1-yl]butan-1-one;2,2,2-trifluoroacetic acid	Investigative	49797061	C22H23F5N2O3	458.4	C[C@@H](C1=CC=C(C=C1)C2=CC=CC=C2F)[C@@H](C(=O)N3CC[C@@H](C3)F)N.C(=O)(C(F)(F)F)O	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	BVEU96	2-({2-[(3R)-3-Aminopiperidin-1-yl]-6-bromo-4-oxo-3,4-dihydroquinazolin-3-yl}methyl)benzonitrile	Investigative	16658102	C21H20BrN5O	438.3	C1C[C@H](CN(C1)C2=NC3=C(C=C(C=C3)Br)C(=O)N2CC4=CC=CC=C4C#N)N	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	BVHL24	(2S,3S)-3-Amino-4-[(3S)-3-fluoropyrrolidin-1-yl]-N,N-dimethyl-2-[4-(5-methyl-[1,2,4]triazolo[1,5-a]pyridin-6-yl)phenyl]-4-oxobutanamide;2,2,2-trifluoroacetic acid	Investigative	11541277	C25H28F4N6O4	552.5	CC1=C(C=CC2=NC=NN12)C3=CC=C(C=C3)[C@@H]([C@@H](C(=O)N4CC[C@@H](C4)F)N)C(=O)N(C)C.C(=O)(C(F)(F)F)O	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	BVKQ09	N-[5-[(3R,5S,6R)-5-Amino-6-(2,5-difluorophenyl)oxan-3-yl]-4,6-dihydro-1H-pyrrolo[3,4-c]pyrazol-3-yl]cyclopropanecarboxamide	Investigative	127035377	C20H23F2N5O2	403.4	C1CC1C(=O)NC2=NNC3=C2CN(C3)[C@@H]4C[C@@H]([C@H](OC4)C5=C(C=CC(=C5)F)F)N	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	BVN3I5	(2S,3S)-2-Amino-3-(3,4-difluorophenyl)-1-[(3S)-3-fluoropyrrolidin-1-yl]butan-1-one;2,2,2-trifluoroacetic acid	Investigative	49797049	C16H18F6N2O3	400.32	C[C@@H](C1=CC(=C(C=C1)F)F)[C@@H](C(=O)N2CC[C@@H](C2)F)N.C(=O)(C(F)(F)F)O	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	BVO2Q3	2-({2-[(3R)-3-Aminopiperidin-1-yl]-5-fluoro-4-oxo-3,4-dihydroquinazolin-3-yl}methyl)benzonitrile	Investigative	16658022	C21H20FN5O	377.4	C1C[C@H](CN(C1)C2=NC3=C(C(=CC=C3)F)C(=O)N2CC4=CC=CC=C4C#N)N	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	BW05BP	N-[4-[(2S,3S)-3-Amino-1-(dimethylamino)-4-[(3S)-3-fluoropyrrolidin-1-yl]-1,4-dioxobutan-2-yl]phenyl]-4-fluoro-N-methylbenzamide;2,2,2-trifluoroacetic acid	Investigative	49797347	C26H29F5N4O5	572.5	CN(C)C(=O)[C@@H](C1=CC=C(C=C1)N(C)C(=O)C2=CC=C(C=C2)F)[C@@H](C(=O)N3CC[C@@H](C3)F)N.C(=O)(C(F)(F)F)O	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	BW1L0O	(3R)-3-Amino-1-[5,8-dimethyl-3-(trifluoromethyl)-6,8-dihydro-5H-[1,2,4]triazolo[4,3-a]pyrazin-7-yl]-4-(2,4,5-trifluorophenyl)butan-1-one;hydrochloride	Investigative	45263673	C18H20ClF6N5O	471.8	CC1CN(C(C2=NN=C(N12)C(F)(F)F)C)C(=O)C[C@@H](CC3=CC(=C(C=C3F)F)F)N.Cl	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	BW1P0Q	N-[5-[(3R,5S,6R)-5-Amino-6-(2,5-difluorophenyl)oxan-3-yl]-4,6-dihydro-1H-pyrrolo[3,4-c]pyrazol-3-yl]-1,3-thiazole-2-carboxamide	Investigative	127035378	C20H20F2N6O2S	446.5	C1[C@H](CO[C@@H]([C@H]1N)C2=C(C=CC(=C2)F)F)N3CC4=C(C3)NN=C4NC(=O)C5=NC=CS5	IC50 = 55000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	BW2SM9	(3R)-3-Amino-1-[(5R,8R)-5,8-dimethyl-3-(trifluoromethyl)-6,8-dihydro-5H-[1,2,4]triazolo[4,3-a]pyrazin-7-yl]-4-(2,4,5-trifluorophenyl)butan-1-one;hydrochloride	Investigative	24777568	C18H20ClF6N5O	471.8	C[C@@H]1CN([C@@H](C2=NN=C(N12)C(F)(F)F)C)C(=O)C[C@@H](CC3=CC(=C(C=C3F)F)F)N.Cl	IC50 = 70000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	BW48BG	(2S,3S)-3-Amino-N,N-diethyl-2-[4-(4-fluorophenyl)phenyl]-4-[(3S)-3-fluoropyrrolidin-1-yl]-4-oxobutanamide;2,2,2-trifluoroacetic acid	Investigative	49797007	C26H30F5N3O4	543.5	CCN(CC)C(=O)[C@@H](C1=CC=C(C=C1)C2=CC=C(C=C2)F)[C@@H](C(=O)N3CC[C@@H](C3)F)N.C(=O)(C(F)(F)F)O	IC50 = 52000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	BW4OD5	cis-N-(4-((R)-1-Amino-2-(2,5-difluorophenyl)ethyl)cyclohexyl)-N-methylacetamide	Investigative	53317575	C17H24F2N2O	310.4	CC(=O)N(C)C1CCC(CC1)[C@@H](CC2=C(C=CC(=C2)F)F)N	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	BW69DB	(2S,3S)-2-Amino-1-[(3S)-3-fluoropyrrolidin-1-yl]-3-(4-pyrimidin-5-ylphenyl)butan-1-one;2,2,2-trifluoroacetic acid	Investigative	49797065	C20H22F4N4O3	442.4	C[C@@H](C1=CC=C(C=C1)C2=CN=CN=C2)[C@@H](C(=O)N3CC[C@@H](C3)F)N.C(=O)(C(F)(F)F)O	IC50 = 57000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	BW71JF	(2S)-2-Amino-1-(2-diphenoxyphosphorylpyrrolidin-1-yl)-3-methyl-butan-1-one	Investigative	11825584	C21H27N2O4P	402.4	CC(C)[C@@H](C(=O)N1CCCC1P(=O)(OC2=CC=CC=C2)OC3=CC=CC=C3)N	IC50 = 126000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	BW7AS9	(3R,4R)-1-Pyrimidin-4-yl-4-(2,4,5-trifluorophenyl)piperidin-3-amine;2,2,2-trifluoroacetic acid	Investigative	49797232	C17H16F6N4O2	422.32	C1CN(C[C@@H]([C@H]1C2=CC(=C(C=C2F)F)F)N)C3=NC=NC=C3.C(=O)(C(F)(F)F)O	IC50 = 60000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	BW8D1L	3-Amino-N-[4-[(1R)-1-amino-2-(2,5-difluorophenyl)ethyl]cyclohexyl]-N-methylpropanamide	Investigative	53322758	C18H27F2N3O	339.4	CN(C1CCC(CC1)[C@@H](CC2=C(C=CC(=C2)F)F)N)C(=O)CCN	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	BWEZ83	5-[4-[(2S,3S)-3-Amino-4-oxo-4-pyrrolidin-1-ylbutan-2-yl]phenyl]-1-methylpyridin-2-one;2,2,2-trifluoroacetic acid	Investigative	49797106	C22H26F3N3O4	453.5	C[C@@H](C1=CC=C(C=C1)C2=CN(C(=O)C=C2)C)[C@@H](C(=O)N3CCCC3)N.C(=O)(C(F)(F)F)O	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	BWF68C	(3R)-3-Amino-1-(2-tert-butyl-1,4-dimethyl-6,7-dihydro-1H-imidazo[4,5-c]pyridin-5(4H)-yl)-4-(2,4,5-trifluorophenyl)butan-1-one	Investigative	44443737	C22H29F3N4O	422.5	CC1C2=C(CCN1C(=O)C[C@@H](CC3=CC(=C(C=C3F)F)F)N)N(C(=N2)C(C)(C)C)C	IC50 = 80000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	BWG4K1	(2S,3S)-2-Amino-4-cyclopropyl-1-[(3S)-3-fluoropyrrolidin-1-yl]-3-[3-(2-methyl-4-methylsulfonylphenyl)-1,2,4-oxadiazol-5-yl]butan-1-one;2,2,2-trifluoroacetic acid	Investigative	49797199	C23H28F4N4O6S	564.6	CC1=C(C=CC(=C1)S(=O)(=O)C)C2=NOC(=N2)[C@@H](CC3CC3)[C@@H](C(=O)N4CC[C@@H](C4)F)N.C(=O)(C(F)(F)F)O	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	BWIO37	(3R,4R)-1-(3-Ethyl-[1,2,4]triazolo[4,3-b]pyridazin-6-yl)-4-(2,4,5-trifluorophenyl)piperidin-3-amine;2,2,2-trifluoroacetic acid	Investigative	49797251	C20H20F6N6O2	490.4	CCC1=NN=C2N1N=C(C=C2)N3CC[C@@H]([C@H](C3)N)C4=CC(=C(C=C4F)F)F.C(=O)(C(F)(F)F)O	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	BWJ1G7	N-[4-[(1R)-1-Amino-2-(2,5-difluorophenyl)ethyl]cyclohexyl]-N,2-dimethylpropanamide	Investigative	53322814	C19H28F2N2O	338.4	CC(C)C(=O)N(C)C1CCC(CC1)[C@@H](CC2=C(C=CC(=C2)F)F)N	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	BWJN10	2-[[7-(1,4-Diazepan-1-yl)-3-methyl-2-oxoimidazo[4,5-b]pyridin-1-yl]methyl]benzonitrile	Investigative	53311073	C20H22N6O	362.4	CN1C2=NC=CC(=C2N(C1=O)CC3=CC=CC=C3C#N)N4CCCNCC4	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	BWKU19	(2S,3S)-3-Amino-4-[(3S)-3-fluoropyrrolidin-1-yl]-N,N-dimethyl-2-[4-[methyl-(4-methylphenyl)sulfonylamino]phenyl]-4-oxobutanamide;2,2,2-trifluoroacetic acid	Investigative	49797345	C26H32F4N4O6S	604.6	CC1=CC=C(C=C1)S(=O)(=O)N(C)C2=CC=C(C=C2)[C@@H]([C@@H](C(=O)N3CC[C@@H](C3)F)N)C(=O)N(C)C.C(=O)(C(F)(F)F)O	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	BWY96R	(2S,3S)-2-Amino-3-[4-(2,4-dichlorophenyl)-1,3-oxazol-2-yl]-1-pyrrolidin-1-ylbutan-1-one;2,2,2-trifluoroacetic acid	Investigative	49797202	C19H20Cl2F3N3O4	482.3	C[C@H](C1=NC(=CO1)C2=C(C=C(C=C2)Cl)Cl)[C@@H](C(=O)N3CCCC3)N.C(=O)(C(F)(F)F)O	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	BX0H4O	(2S,3As,6aS)-1-[(3R)-3-amino-4-(4-fluorophenyl)butanoyl]-3,3a,4,5,6,6a-hexahydro-2H-cyclopenta[b]pyrrole-2-carbonitrile	Investigative	118712781	C18H22FN3O	315.4	C1C[C@H]2C[C@H](N([C@H]2C1)C(=O)C[C@@H](CC3=CC=C(C=C3)F)N)C#N	IC50 = 51600 nM	Poor binder
T15855	Dipeptidyl peptidase 8	BX1BH7	(3R)-1-(8-((1H-Pyrazol-1-yl)methyl)-2-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[1,5-a]pyrazin-7(8H)-yl)-3-amino-4-(2,4,5-trifluorophenyl)butan-1-one	Investigative	44444390	C20H19F6N7O	487.4	C1CN2C(=NC(=N2)C(F)(F)F)C(N1C(=O)C[C@@H](CC3=CC(=C(C=C3F)F)F)N)CN4C=CC=N4	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	BX36TG	trans-N-(4-((R)-1-Amino-2-(2,5-difluorophenyl)ethyl)cyclohexyl)-N-methylbenzenesulfonamide	Investigative	53321621	C21H26F2N2O2S	408.5	CN(C1CCC(CC1)[C@@H](CC2=C(C=CC(=C2)F)F)N)S(=O)(=O)C3=CC=CC=C3	IC50 = 61000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	BX4AI2	trans-4-((R)-1-Amino-2-(2,5-difluorophenyl)ethyl)-N-benzyl-N-ethylcyclohexanamine	Investigative	53322823	C23H30F2N2	372.5	CCN(CC1=CC=CC=C1)C2CCC(CC2)[C@@H](CC3=C(C=CC(=C3)F)F)N	IC50 = 76000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	BX5EA9	(1S,2R,5S)-5-[3-(Trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-A]pyrazin-7(8H)-YL]-2-(2,4,5-trifluorophenyl)cyclohexanamine	Investigative	11538992	C18H19F6N5	419.4	C1C[C@@H]([C@H](C[C@H]1N2CCN3C(=NN=C3C(F)(F)F)C2)N)C4=CC(=C(C=C4F)F)F	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	BX65PY	(3R)-3-Amino-1-[8-[(2-fluorophenyl)methyl]-3-(trifluoromethyl)-6,8-dihydro-5H-[1,2,4]triazolo[4,3-a]pyrazin-7-yl]-4-(2,4,5-trifluorophenyl)butan-1-one;hydrochloride	Investigative	45265965	C23H21ClF7N5O	551.9	C1CN2C(=NN=C2C(F)(F)F)C(N1C(=O)C[C@@H](CC3=CC(=C(C=C3F)F)F)N)CC4=CC=CC=C4F.Cl	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	BXA17V	2,2,2-Trifluoroacetic acid;(2R,3R)-3-(2,4,5-trifluorophenyl)-1,2,3,4-tetrahydropyrido[1,2-a]benzimidazol-2-amine	Investigative	49797636	C19H15F6N3O2	431.3	C1[C@@H]([C@H](CN2C1=NC3=CC=CC=C32)N)C4=CC(=C(C=C4F)F)F.C(=O)(C(F)(F)F)O	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	BXC53F	(2R,3S,5R)-5-(4,6-Dihydro-1H-pyrrolo[3,4-c]pyrazol-5-yl)-2-(2,4,5-trifluorophenyl)oxan-3-amine	Investigative	73346174	C16H17F3N4O	338.33	C1[C@H](CO[C@@H]([C@H]1N)C2=CC(=C(C=C2F)F)F)N3CC4=C(C3)NN=C4	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	BXC8H5	(2R,3S,5R)-2-(2,5-Difluorophenyl)-5-(2-propylsulfonyl-4,6-dihydropyrrolo[3,4-c]pyrazol-5-yl)oxan-3-amine	Investigative	127035241	C19H24F2N4O3S	426.5	CCCS(=O)(=O)N1C=C2CN(CC2=N1)[C@@H]3C[C@@H]([C@H](OC3)C4=C(C=CC(=C4)F)F)N	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	BXF60I	(2S,3S)-3-Amino-2-[4-(4-fluorophenyl)phenyl]-4-[(3S)-3-fluoropyrrolidin-1-yl]-4-oxobutanamide;2,2,2-trifluoroacetic acid	Investigative	49797035	C22H22F5N3O4	487.4	C1CN(C[C@H]1F)C(=O)[C@H]([C@H](C2=CC=C(C=C2)C3=CC=C(C=C3)F)C(=O)N)N.C(=O)(C(F)(F)F)O	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	BXH5N6	(2R)-1-[2-[2-[3-(3,4-Dimethoxyphenyl)-2-oxoimidazolidin-1-yl]ethylamino]acetyl]pyrrolidine-2-carbonitrile;oxalic acid	Investigative	49859910	C22H29N5O8	491.5	COC1=C(C=C(C=C1)N2CCN(C2=O)CCNCC(=O)N3CCC[C@@H]3C#N)OC.C(=O)(C(=O)O)O	IC50 = 53000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	BXP65Y	(3R)-3-Amino-4-(2,5-difluorophenyl)-1-[2-(trifluoromethyl)-4H,5H,6H,7H-pyrido[3,4-d][1,3]thiazol-5-yl]butan-1-one	Investigative	11269712	C17H16F5N3OS	405.4	C1CN(CC2=C1SC(=N2)C(F)(F)F)C(=O)C[C@@H](CC3=C(C=CC(=C3)F)F)N	IC50 = 63000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	BXT1B4	(2S,3S,5S)-2-(2,5-Difluorophenyl)-5-(4,6-dihydro-1H-pyrrolo[3,4-c]pyrazol-5-yl)oxan-3-amine	Investigative	72193505	C16H18F2N4O	320.34	C1[C@@H](CO[C@H]([C@H]1N)C2=C(C=CC(=C2)F)F)N3CC4=C(C3)NN=C4	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	BXT7N1	(2S,3S)-2-Amino-1-[(3S)-3-fluoropyrrolidin-1-yl]-3-(4-phenylphenyl)butan-1-one;2,2,2-trifluoroacetic acid	Investigative	49797052	C22H24F4N2O3	440.4	C[C@@H](C1=CC=C(C=C1)C2=CC=CC=C2)[C@@H](C(=O)N3CC[C@@H](C3)F)N.C(=O)(C(F)(F)F)O	IC50 = 85000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	BXU15A	(2S,3S)-2-Amino-1-[(3S)-3-fluoropyrrolidin-1-yl]-3-[4-(4-methoxyphenyl)phenyl]butan-1-one;2,2,2-trifluoroacetic acid	Investigative	49797066	C23H26F4N2O4	470.5	C[C@@H](C1=CC=C(C=C1)C2=CC=C(C=C2)OC)[C@@H](C(=O)N3CC[C@@H](C3)F)N.C(=O)(C(F)(F)F)O	IC50 = 74000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	BXZ92E	7-[(3R,4R)-3-Amino-4-(2,4,5-trifluorophenyl)piperidin-1-yl]pyrimido[1,2-b]pyridazin-2-one;2,2,2-trifluoroacetic acid	Investigative	23661716	C20H17F6N5O3	489.4	C1CN(C[C@@H]([C@H]1C2=CC(=C(C=C2F)F)F)N)C3=NN4C=CC(=O)N=C4C=C3.C(=O)(C(F)(F)F)O	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	BXZQ41	Ethyl 3-[4-[(2S,3S)-3-amino-4-[(3S)-3-fluoropyrrolidin-1-yl]-4-oxobutan-2-yl]phenyl]benzoate;2,2,2-trifluoroacetic acid	Investigative	49797081	C25H28F4N2O5	512.5	CCOC(=O)C1=CC=CC(=C1)C2=CC=C(C=C2)[C@H](C)[C@@H](C(=O)N3CC[C@@H](C3)F)N.C(=O)(C(F)(F)F)O	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	BY1AK2	2-({2-[(3r)-3-Aminopiperidin-1-Yl]-5-Methyl-6,9-Dioxo-5,6,7,9-Tetrahydro-1h-Imidazo[1,2-A]purin-1-Yl}methyl)-4-Fluorobenzonitrile	Investigative	71203748	C21H21FN8O2	436.4	CN1C(=O)CN2C1=NC3=C(C2=O)N(C(=N3)N4CCC[C@H](C4)N)CC5=C(C=CC(=C5)F)C#N	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	BY3P4Q	6-[(3R)-3-Aminopiperidin-1-yl]-1-but-2-ynyl-3-(pyrimidin-2-ylmethyl)pyrimidine-2,4-dione	Investigative	71731357	C18H22N6O2	354.4	CC#CCN1C(=CC(=O)N(C1=O)CC2=NC=CC=N2)N3CCC[C@H](C3)N	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	BY3SR5	6-[(3R)-3-Aminopiperidin-1-yl]-1-[(2-bromo-5-fluorophenyl)methyl]-3-methylpyrimidine-2,4-dione	Investigative	11464036	C17H20BrFN4O2	411.3	CN1C(=O)C=C(N(C1=O)CC2=C(C=CC(=C2)F)Br)N3CCC[C@H](C3)N	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	BY5MT1	(2S,3S)-2-Amino-3-[3-(3,5-dichlorophenyl)-1,2,4-oxadiazol-5-yl]-1-(pyrrolidin-1-yl)butan-1-one	Investigative	23644665	C16H18Cl2N4O2	369.2	C[C@H](C1=NC(=NO1)C2=CC(=CC(=C2)Cl)Cl)[C@@H](C(=O)N3CCCC3)N	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	BY6TK4	(3R)-3-Amino-1-[3-(1,1,2,2,2-pentafluoroethyl)-6,8-dihydro-5H-[1,2,4]triazolo[4,3-a]pyrazin-7-yl]-4-(2,4,5-trifluorophenyl)butan-1-one;hydrochloride	Investigative	11306467	C17H16ClF8N5O	493.8	C1CN2C(=NN=C2C(C(F)(F)F)(F)F)CN1C(=O)C[C@@H](CC3=CC(=C(C=C3F)F)F)N.Cl	IC50 = 80000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	BY70NV	1-[3-(Aminomethyl)-4-(4-methylphenyl)-2-(2-methylpropyl)quinolin-6-yl]piperazine-2,5-dione;dihydrochloride	Investigative	53357353	C25H30Cl2N4O2	489.4	CC1=CC=C(C=C1)C2=C(C(=NC3=C2C=C(C=C3)N4CC(=O)NCC4=O)CC(C)C)CN.Cl.Cl	IC50 ~ 60000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	BY8A7O	(2R,3R)-2-Amino-3-(2,4,5-trifluorophenyl)-1,2,3,4-tetrahydropyrido[1,2-a]benzimidazole-7-carboxylic acid;2,2,2-trifluoroacetic acid	Investigative	49797616	C20H15F6N3O4	475.3	C1[C@@H]([C@H](CN2C1=NC3=C2C=CC(=C3)C(=O)O)N)C4=CC(=C(C=C4F)F)F.C(=O)(C(F)(F)F)O	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	BY93LZ	(2S,3S)-2-Amino-1-[(3S)-3-fluoropyrrolidin-1-yl]-3-[4-fluoro-2-(trifluoromethyl)phenyl]butan-1-one;2,2,2-trifluoroacetic acid	Investigative	49797048	C17H18F8N2O3	450.32	C[C@@H](C1=C(C=C(C=C1)F)C(F)(F)F)[C@@H](C(=O)N2CC[C@@H](C2)F)N.C(=O)(C(F)(F)F)O	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	BYO83J	2,2,2-Trifluoroacetic acid;(3R,4R)-1-[2-(trifluoromethyl)-[1,2,4]triazolo[1,5-b]pyridazin-6-yl]-4-(2,4,5-trifluorophenyl)piperidin-3-amine	Investigative	49797244	C19H15F9N6O2	530.3	C1CN(C[C@@H]([C@H]1C2=CC(=C(C=C2F)F)F)N)C3=NN4C(=NC(=N4)C(F)(F)F)C=C3.C(=O)(C(F)(F)F)O	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	BYQ93J	(2S,3S)-2-Amino-1-[(3S)-3-fluoropyrrolidin-1-yl]-3-(4-methoxyphenyl)butan-1-one;2,2,2-trifluoroacetic acid	Investigative	49797057	C17H22F4N2O4	394.4	C[C@@H](C1=CC=C(C=C1)OC)[C@@H](C(=O)N2CC[C@@H](C2)F)N.C(=O)(C(F)(F)F)O	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	BYQE45	(3R)-3-Amino-1-[5,5-dimethyl-3-(trifluoromethyl)-6,8-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7-yl]-4-(2,4,5-trifluorophenyl)butan-1-one;hydrochloride	Investigative	24777686	C18H20ClF6N5O	471.8	CC1(CN(CC2=NN=C(N21)C(F)(F)F)C(=O)C[C@@H](CC3=CC(=C(C=C3F)F)F)N)C.Cl	IC50 = 66000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	BYT61V	Methyl 2-[4-[[[(4R)-3-[3-amino-4-(2-fluorophenyl)butanoyl]-1,3-thiazolidine-4-carbonyl]amino]methyl]phenyl]acetate;2,2,2-trifluoroacetic acid	Investigative	49796933	C26H29F4N3O6S	587.6	COC(=O)CC1=CC=C(C=C1)CNC(=O)[C@@H]2CSCN2C(=O)CC(CC3=CC=CC=C3F)N.C(=O)(C(F)(F)F)O	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	BYTZ29	(2S,3S)-2-Amino-3-(4-bromophenyl)-1-[(3S)-3-fluoropyrrolidin-1-yl]butan-1-one;2,2,2-trifluoroacetic acid	Investigative	49797047	C16H19BrF4N2O3	443.23	C[C@@H](C1=CC=C(C=C1)Br)[C@@H](C(=O)N2CC[C@@H](C2)F)N.C(=O)(C(F)(F)F)O	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	BYVZ67	Chembl4212894	Investigative	145964407	C18H21N5O	323.4	CC1=CC=C(C=C1)CN2C3=CC=NN3C(=O)C=C2N4CCNCC4	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	BZ08GA	US9051329, Example 3	Investigative	71203769	C20H21F2N7O2	429.4	CN1C(=O)CN2C1=NC3=C(C2=O)N(C(=N3)N4CCC[C@H](C4)N)CC5=C(C=CC(=C5)F)F	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	BZ08SH	2-[[7-(3-Aminoazepan-1-yl)-3-methyl-2-oxoimidazo[4,5-b]pyridin-1-yl]methyl]benzonitrile	Investigative	53311072	C21H24N6O	376.5	CN1C2=NC=CC(=C2N(C1=O)CC3=CC=CC=C3C#N)N4CCCCC(C4)N	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	BZ0KU1	trans-(R)-1-(4-((R)-1-Amino-2-(2,5-difluorophenyl)ethyl)cyclohexyl)piperidine-3-carboxamide	Investigative	53322952	C20H29F2N3O	365.5	C1C[C@H](CN(C1)C2CCC(CC2)[C@@H](CC3=C(C=CC(=C3)F)F)N)C(=O)N	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	BZ19FJ	7-[(3R)-3-Aminopiperidin-1-yl]-1-[(2-fluorophenyl)methyl]-3-methylimidazo[4,5-b]pyridin-2-one	Investigative	53311225	C19H22FN5O	355.4	CN1C2=NC=CC(=C2N(C1=O)CC3=CC=CC=C3F)N4CCC[C@H](C4)N	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	BZ43AV	(R)-1-(4-(3-Chloropyridin-4-yl)phenyl)-2-(2,5-difluorophenyl)ethanamine	Investigative	44561010	C19H15ClF2N2	344.8	C1=CC(=CC=C1C2=C(C=NC=C2)Cl)[C@@H](CC3=C(C=CC(=C3)F)F)N	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	BZ4JS9	N-[4-[5-[(2S,3S)-3-Amino-4-[(3S)-3-fluoropyrrolidin-1-yl]-4-oxobutan-2-yl]-1,2,4-oxadiazol-3-yl]-3-chlorophenyl]methanesulfonamide;2,2,2-trifluoroacetic acid	Investigative	49797204	C19H22ClF4N5O6S	559.9	C[C@H](C1=NC(=NO1)C2=C(C=C(C=C2)NS(=O)(=O)C)Cl)[C@@H](C(=O)N3CC[C@@H](C3)F)N.C(=O)(C(F)(F)F)O	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	BZ51JA	N-[4-[(1R)-1-Amino-2-(2,5-difluorophenyl)ethyl]cyclohexyl]-N-methyl-2-(trifluoromethyl)benzenesulfonamide	Investigative	53326691	C22H25F5N2O2S	476.5	CN(C1CCC(CC1)[C@@H](CC2=C(C=CC(=C2)F)F)N)S(=O)(=O)C3=CC=CC=C3C(F)(F)F	IC50 = 65000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	BZ51VL	CID 53311140	Investigative	53311140	C19H19N5O2	349.4	C1C[C@H](CN(C1)C2=C3C(=NC=C2)OC(=O)N3CC4=CC=CC=C4C#N)N	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	BZ5V2N	(3R)-3-Amino-4-(2,5-difluorophenyl)-1-[1-methyl-3-(1,1,2,2,2-pentafluoroethyl)-1H,4H,5H,6H,7H-pyrazolo[4,3-c]pyridin-5-yl]butan-1-one	Investigative	23645926	C19H19F7N4O	452.4	CN1C2=C(CN(CC2)C(=O)C[C@@H](CC3=C(C=CC(=C3)F)F)N)C(=N1)C(C(F)(F)F)(F)F	IC50 = 56000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	BZ78WO	(3R)-1-(8-((1H-1,2,4-Triazol-1-yl)methyl)-2-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[1,5-a]pyrazin-7(8H)-yl)-3-amino-4-(2,4,5-trifluorophenyl)butan-1-one	Investigative	10254918	C19H18F6N8O	488.4	C1CN2C(=NC(=N2)C(F)(F)F)C(N1C(=O)C[C@@H](CC3=CC(=C(C=C3F)F)F)N)CN4C=NC=N4	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	BZ8U3A	2,2,2-Trifluoroacetic acid;(2R,3R)-8-(trifluoromethyl)-3-(2,4,5-trifluorophenyl)-1,2,3,4-tetrahydropyrido[1,2-a]benzimidazol-2-amine	Investigative	49797615	C20H14F9N3O2	499.3	C1[C@@H]([C@H](CN2C1=NC3=C2C=C(C=C3)C(F)(F)F)N)C4=CC(=C(C=C4F)F)F.C(=O)(C(F)(F)F)O	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	BZB1I0	4-Amino-N-[4-[(1R)-1-amino-2-(2,5-difluorophenyl)ethyl]cyclohexyl]-N-methylbenzenesulfonamide	Investigative	53321472	C21H27F2N3O2S	423.5	CN(C1CCC(CC1)[C@@H](CC2=C(C=CC(=C2)F)F)N)S(=O)(=O)C3=CC=C(C=C3)N	IC50 = 69000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	BZB9H1	(2S,3S)-2-Amino-3-[5-(2,4-dichlorophenyl)-1,3,4-oxadiazol-2-yl]-1-pyrrolidin-1-ylbutan-1-one;2,2,2-trifluoroacetic acid	Investigative	49797200	C18H19Cl2F3N4O4	483.3	C[C@H](C1=NN=C(O1)C2=C(C=C(C=C2)Cl)Cl)[C@@H](C(=O)N3CCCC3)N.C(=O)(C(F)(F)F)O	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	BZCI06	N-[(3R)-1-[1-[(2-Cyanophenyl)methyl]-3-methyl-2-oxoimidazo[4,5-b]pyridin-7-yl]piperidin-3-yl]acetamide	Investigative	118712517	C22H24N6O2	404.5	CC(=O)N[C@@H]1CCCN(C1)C2=C3C(=NC=C2)N(C(=O)N3CC4=CC=CC=C4C#N)C	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	BZD8S1	N-[4-[(1R)-1-Amino-2-(2,5-difluorophenyl)ethyl]cyclohexyl]-N,1-dimethylimidazole-4-sulfonamide	Investigative	53324142	C19H26F2N4O2S	412.5	CN1C=C(N=C1)S(=O)(=O)N(C)C2CCC(CC2)[C@@H](CC3=C(C=CC(=C3)F)F)N	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	BZEX51	(3R)-3-Amino-1-(4-cyclopropyl-1-methyl-2-(trifluoromethyl)-6,7-dihydro-1H-imidazo[4,5-c]pyridin-5(4H)-yl)-4-(2,4,5-trifluorophenyl)butan-1-one	Investigative	44443729	C21H22F6N4O	460.4	CN1C2=C(C(N(CC2)C(=O)C[C@@H](CC3=CC(=C(C=C3F)F)F)N)C4CC4)N=C1C(F)(F)F	IC50 = 85000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	BZL0I7	(2S,3S)-2-Amino-1-[(3S)-3-fluoropyrrolidin-1-yl]-3-[4-[4-(trifluoromethyl)phenyl]phenyl]butan-1-one;2,2,2-trifluoroacetic acid	Investigative	49797076	C23H23F7N2O3	508.4	C[C@@H](C1=CC=C(C=C1)C2=CC=C(C=C2)C(F)(F)F)[C@@H](C(=O)N3CC[C@@H](C3)F)N.C(=O)(C(F)(F)F)O	IC50 = 64000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	BZNV25	6-[(3R)-3-Aminopiperidin-1-yl]-1-but-2-ynyl-3-[(6-methylquinolin-2-yl)methyl]pyrimidine-2,4-dione	Investigative	71731479	C24H27N5O2	417.5	CC#CCN1C(=CC(=O)N(C1=O)CC2=NC3=C(C=C2)C=C(C=C3)C)N4CCC[C@H](C4)N	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	BZOW38	N-[4-[(1R)-1-Amino-2-(2,5-difluorophenyl)ethyl]cyclohexyl]-N,3,5-trimethyl-1,2-oxazole-4-carboxamide	Investigative	53321495	C21H27F2N3O2	391.5	CC1=C(C(=NO1)C)C(=O)N(C)C2CCC(CC2)[C@@H](CC3=C(C=CC(=C3)F)F)N	IC50 = 58000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	BZYP13	(2R)-2-[4-[[[(2S)-1-[3-Amino-4-(2,5-difluorophenyl)butanoyl]pyrrolidine-2-carbonyl]amino]methyl]phenoxy]-3-methylbutanoic acid;2,2,2-trifluoroacetic acid	Investigative	49796953	C29H34F5N3O7	631.6	CC(C)[C@H](C(=O)O)OC1=CC=C(C=C1)CNC(=O)[C@@H]2CCCN2C(=O)CC(CC3=C(C=CC(=C3)F)F)N.C(=O)(C(F)(F)F)O	IC50 ~ 100000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	D07ALM	N4-(4-chlorobenzyl)-2,4-diaminobutanoylpiperidine	Investigative	11232124	C16H24ClN3O	309.83	C1CCN(CC1)C(=O)[C@H](CCNCC2=CC=C(C=C2)Cl)N	IC50 = 142000 nM	Poor binder
T15855	Dipeptidyl peptidase 8	D07IJU	(S)-pyrrolidin-1-yl(pyrrolidin-2-yl)methanone	Investigative	13578534	C9H16N2O	168.24	C1CCN(C1)C(=O)[C@@H]2CCCN2	IC50 = 50000 nM	Poor binder