TTD_Target_ID	Target_Name	TTD_Drug_ID	Drug_Name	Drug_Highest_Status	Drug_PubchemID	Molecular_Formula	Molecular_Weight	Canonical_SMILES	Activity	Binder_Type
T16514	Fatty acid synthase	D04AIT	B-Lactams	Approved	5280445	C15H10O6	286.24	C1=CC(=C(C=C1C2=CC(=O)C3=C(C=C(C=C3O2)O)O)O)O	IC50 = 62500 nM	Poor binder
T16514	Fatty acid synthase	D0KL4J	Rabeprazole	Approved	5029	C18H21N3O3S	359.4	CC1=C(C=CN=C1CS(=O)C2=NC3=CC=CC=C3N2)OCCCOC	IC50 = 52000 nM	Poor binder
T16514	Fatty acid synthase	D05TPI	EPICATECHIN	Phase 2	72276	C15H14O6	290.27	C1[C@H]([C@H](OC2=CC(=CC(=C21)O)O)C3=CC(=C(C=C3)O)O)O	IC50 ~ 100000 nM	Poor binder
T16514	Fatty acid synthase	D09CKU	PMID26394986-Compound-44	Patented	65064	C22H18O11	458.4	C1[C@H]([C@H](OC2=CC(=CC(=C21)O)O)C3=CC(=C(C(=C3)O)O)O)OC(=O)C4=CC(=C(C(=C4)O)O)O	IC50 = 51970 nM	Poor binder
T16514	Fatty acid synthase	B0MA8U	Egonol	Investigative	485186	C19H18O5	326.3	COC1=CC(=CC2=C1OC(=C2)C3=CC4=C(C=C3)OCO4)CCCO	IC50 = 91070 nM	Poor binder
T16514	Fatty acid synthase	B0WNL8	N-[3-[4-(4-Cyanophenyl)-4-fluoropiperidine-1-carbonyl]-2,4-dimethylphenyl]-6-(propan-2-ylamino)pyridine-3-carboxamide	Investigative	68288723	C30H32FN5O2	513.6	CC1=C(C(=C(C=C1)NC(=O)C2=CN=C(C=C2)NC(C)C)C)C(=O)N3CCC(CC3)(C4=CC=C(C=C4)C#N)F	IC50 ~ 50000 nM	Poor binder
T16514	Fatty acid synthase	B0WS1Y	4-[1-[2-Cyclobutyl-5-[5-(methoxymethyl)-1H-1,2,4-triazol-3-yl]-4-methylbenzoyl]piperidin-4-yl]benzonitrile	Investigative	68289165	C28H31N5O2	469.6	CC1=CC(=C(C=C1C2=NNC(=N2)COC)C(=O)N3CCC(CC3)C4=CC=C(C=C4)C#N)C5CCC5	IC50 ~ 50000 nM	Poor binder
T16514	Fatty acid synthase	B3C6OZ	4-[1-[5-[3-(2-Methoxyethoxy)-4-methyl-1H-pyrazol-5-yl]-2,4-dimethylbenzoyl]azetidin-3-yl]benzonitrile	Investigative	72947528	C26H28N4O3	444.5	CC1=CC(=C(C=C1C2=C(C(=NN2)OCCOC)C)C(=O)N3CC(C3)C4=CC=C(C=C4)C#N)C	IC50 = 50000 nM	Poor binder
T16514	Fatty acid synthase	B5D6MP	N-[2-[4-(4-Cyanophenyl)piperidine-1-carbonyl]-5-methylpyridin-4-yl]-6-(propan-2-ylamino)pyridine-3-carboxamide	Investigative	68288688	C28H30N6O2	482.6	CC1=CN=C(C=C1NC(=O)C2=CN=C(C=C2)NC(C)C)C(=O)N3CCC(CC3)C4=CC=C(C=C4)C#N	IC50 ~ 50000 nM	Poor binder
T16514	Fatty acid synthase	B5RHN6	1-[5-[4-(4-Cyanophenyl)piperidine-1-carbonyl]pyridazin-3-yl]-3-(2-methylpropyl)urea	Investigative	70872774	C22H26N6O2	406.5	CC(C)CNC(=O)NC1=NN=CC(=C1)C(=O)N2CCC(CC2)C3=CC=C(C=C3)C#N	IC50 ~ 50000 nM	Poor binder
T16514	Fatty acid synthase	B5V0OL	Albaspidin PP	Investigative	14378645	C23H28O8	432.5	CCC(=O)C1=C(C(=C(C(C1=O)(C)C)O)CC2=C(C(C(=O)C(=C2O)C(=O)CC)(C)C)O)O	IC50 = 60200 nM	Poor binder
T16514	Fatty acid synthase	B6DO8J	5-(4-(4-Cyanophenyl)piperidine-1-carbonyl)-2-cyclobutyl-4-methylbenzoic acid	Investigative	68288275	C25H26N2O3	402.5	CC1=CC(=C(C=C1C(=O)N2CCC(CC2)C3=CC=C(C=C3)C#N)C(=O)O)C4CCC4	IC50 ~ 50000 nM	Poor binder
T16514	Fatty acid synthase	B6E9DI	4-(1-(4-Cyclobutyl-5-(5-ethyl-4H-1,2,4-triazol-3-yl)-2-methylbenzoyl)piperidin-4-yl)benzonitrile	Investigative	68288884	C28H31N5O	453.6	CCC1=NC(=NN1)C2=C(C=C(C(=C2)C(=O)N3CCC(CC3)C4=CC=C(C=C4)C#N)C)C5CCC5	IC50 ~ 50000 nM	Poor binder
T16514	Fatty acid synthase	B6EUT7	4-[1-[2-Chloro-3-(3,4,6,7-tetrahydropyrano[3,4-d]imidazol-2-yl)benzoyl]piperidin-4-yl]benzonitrile	Investigative	70872346	C25H23ClN4O2	446.9	C1CN(CCC1C2=CC=C(C=C2)C#N)C(=O)C3=CC=CC(=C3Cl)C4=NC5=C(N4)COCC5	IC50 ~ 50000 nM	Poor binder
T16514	Fatty acid synthase	B6KNG4	3-[5-(6-Cyanospiro[1H-2-benzofuran-3,4'-piperidine]-1'-carbonyl)-2-methylphenyl]-1-methyl-1-(oxolan-3-ylmethyl)urea	Investigative	70872591	C28H32N4O4	488.6	CC1=C(C=C(C=C1)C(=O)N2CCC3(CC2)C4=C(CO3)C=C(C=C4)C#N)NC(=O)N(C)CC5CCOC5	IC50 ~ 50000 nM	Poor binder
T16514	Fatty acid synthase	B6KUW5	4-[1-[5-[3-(Cyclopropylmethoxy)-4-methyl-1H-pyrazol-5-yl]-2,4-dimethylbenzoyl]azetidin-3-yl]benzonitrile	Investigative	90066823	C27H28N4O2	440.5	CC1=CC(=C(C=C1C2=C(C(=NN2)OCC3CC3)C)C(=O)N4CC(C4)C5=CC=C(C=C5)C#N)C	IC50 = 50000 nM	Poor binder
T16514	Fatty acid synthase	B6RG8B	1-(3-(4-(4-Cyanophenyl)piperidine-1-carbonyl)-1-methyl-1H-pyrazol-5-yl)-3-isobutylurea	Investigative	68288331	C22H28N6O2	408.5	CC(C)CNC(=O)NC1=CC(=NN1C)C(=O)N2CCC(CC2)C3=CC=C(C=C3)C#N	IC50 ~ 50000 nM	Poor binder
T16514	Fatty acid synthase	B78FJT	4-[1-[2-Methyl-4-methylsulfonyl-5-(5-methyl-1H-1,2,4-triazol-3-yl)benzoyl]piperidin-4-yl]benzonitrile	Investigative	70907847	C24H25N5O3S	463.6	CC1=CC(=C(C=C1C(=O)N2CCC(CC2)C3=CC=C(C=C3)C#N)C4=NNC(=N4)C)S(=O)(=O)C	IC50 ~ 50000 nM	Poor binder
T16514	Fatty acid synthase	B94HTR	5-[4-(4-Cyanophenyl)piperidine-1-carbonyl]-2-methyl-N-[(1-methylpiperidin-4-yl)methyl]benzamide	Investigative	68352607	C28H34N4O2	458.6	CC1=C(C=C(C=C1)C(=O)N2CCC(CC2)C3=CC=C(C=C3)C#N)C(=O)NCC4CCN(CC4)C	IC50 ~ 50000 nM	Poor binder
T16514	Fatty acid synthase	B97CJG	3-Hydroxyflavone	Investigative	11349	C15H10O3	238.24	C1=CC=C(C=C1)C2=C(C(=O)C3=CC=CC=C3O2)O	IC50 ~ 100000 nM	Poor binder
T16514	Fatty acid synthase	B9G1HM	4-[1-[3-[5-(2-Methoxyethyl)-1H-1,2,4-triazol-3-yl]-2-methylbenzoyl]piperidin-4-yl]benzonitrile	Investigative	70907834	C25H27N5O2	429.5	CC1=C(C=CC=C1C(=O)N2CCC(CC2)C3=CC=C(C=C3)C#N)C4=NNC(=N4)CCOC	IC50 ~ 50000 nM	Poor binder
T16514	Fatty acid synthase	B9RI4T	4-[1-[2,3-Dimethyl-5-(3,4,6,7-tetrahydropyrano[3,4-d]imidazol-2-yl)benzoyl]piperidin-4-yl]benzonitrile	Investigative	70874632	C27H28N4O2	440.5	CC1=CC(=CC(=C1C)C(=O)N2CCC(CC2)C3=CC=C(C=C3)C#N)C4=NC5=C(N4)COCC5	IC50 ~ 50000 nM	Poor binder
T16514	Fatty acid synthase	B9X4JK	(10E,12Z)-Octadeca-10,12-dienoic acid	Investigative	5282800	C18H32O2	280.4	CCCCC/C=C\\C=C\\CCCCCCCCC(=O)O	IC50 = 100000 nM	Poor binder
T16514	Fatty acid synthase	BA0O6P	4-[1-[2-Methyl-3-(6-pyrrolidin-1-yl-3H-imidazo[4,5-c]pyridin-2-yl)benzoyl]piperidin-4-yl]benzonitrile	Investigative	71541606	C30H30N6O	490.6	CC1=C(C=CC=C1C(=O)N2CCC(CC2)C3=CC=C(C=C3)C#N)C4=NC5=CC(=NC=C5N4)N6CCCC6	IC50 ~ 50000 nM	Poor binder
T16514	Fatty acid synthase	BBSC56	5-[4-(4-Cyanophenyl)piperidine-1-carbonyl]-2-methyl-N-(oxolan-3-ylmethyl)benzamide	Investigative	70872385	C26H29N3O3	431.5	CC1=C(C=C(C=C1)C(=O)N2CCC(CC2)C3=CC=C(C=C3)C#N)C(=O)NCC4CCOC4	IC50 ~ 50000 nM	Poor binder
T16514	Fatty acid synthase	BF6Q5A	Albaspidin AP	Investigative	25096734	C22H26O8	418.4	CCC(=O)C1=C(C(=C(C(C1=O)(C)C)O)CC2=C(C(C(=O)C(=C2O)C(=O)C)(C)C)O)O	IC50 = 71700 nM	Poor binder
T16514	Fatty acid synthase	BHU91A	Cnc(=O)C1=C(C=C(C)C(=C1)C(=O)N1ccc(CC1)C1=CC=CC2=C1OC=C2)C1ccc1	Investigative	118250864	C27H30N2O3	430.5	CC1=CC(=C(C=C1C(=O)N2CCC(CC2)C3=CC=CC4=C3OC=C4)C(=O)NC)C5CCC5	IC50 = 50000 nM	Poor binder
T16514	Fatty acid synthase	BJ13LB	4-[1-[3-Methyl-5-(6-pyrrolidin-1-yl-3H-imidazo[4,5-c]pyridin-2-yl)benzoyl]piperidin-4-yl]benzonitrile	Investigative	71541605	C30H30N6O	490.6	CC1=CC(=CC(=C1)C(=O)N2CCC(CC2)C3=CC=C(C=C3)C#N)C4=NC5=CC(=NC=C5N4)N6CCCC6	IC50 ~ 50000 nM	Poor binder
T16514	Fatty acid synthase	BJ6KM5	3-[5-(6-Cyanospiro[1H-2-benzofuran-3,4'-piperidine]-1'-carbonyl)-2-methylphenyl]-1-(2-methoxyethyl)-1-methylurea	Investigative	70907804	C26H30N4O4	462.5	CC1=C(C=C(C=C1)C(=O)N2CCC3(CC2)C4=C(CO3)C=C(C=C4)C#N)NC(=O)N(C)CCOC	IC50 ~ 50000 nM	Poor binder
T16514	Fatty acid synthase	BJW59X	4-[1-[3-(1H-Imidazol-2-ylamino)-4-methylbenzoyl]piperidin-4-yl]benzonitrile	Investigative	70872581	C23H23N5O	385.5	CC1=C(C=C(C=C1)C(=O)N2CCC(CC2)C3=CC=C(C=C3)C#N)NC4=NC=CN4	IC50 ~ 50000 nM	Poor binder
T16514	Fatty acid synthase	BK09MP	N-[5-[7-(4-Cyanophenyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyridin-3-yl]-2-methylphenyl]pyrrolidine-1-carboxamide	Investigative	70872622	C25H26N6O	426.5	CC1=C(C=C(C=C1)C2=NN=C3N2CCC(C3)C4=CC=C(C=C4)C#N)NC(=O)N5CCCC5	IC50 ~ 50000 nM	Poor binder
T16514	Fatty acid synthase	BLX7M6	1-[2-[4-(4-Cyanophenyl)piperidine-1-carbonyl]-5-methylpyridin-4-yl]-3-(oxolan-3-yl)urea	Investigative	68352722	C24H27N5O3	433.5	CC1=CN=C(C=C1NC(=O)NC2CCOC2)C(=O)N3CCC(CC3)C4=CC=C(C=C4)C#N	IC50 ~ 50000 nM	Poor binder
T16514	Fatty acid synthase	BN6AT4	Lansoprazole	Investigative	3883	C16H14F3N3O2S	369.4	CC1=C(C=CN=C1CS(=O)C2=NC3=CC=CC=C3N2)OCC(F)(F)F	IC50 = 93000 nM	Poor binder
T16514	Fatty acid synthase	BN8F5H	1-[6-[4-(4-Cyanophenyl)piperidine-1-carbonyl]-3-methylpyridin-2-yl]-3-(oxolan-3-yl)urea	Investigative	70872473	C24H27N5O3	433.5	CC1=C(N=C(C=C1)C(=O)N2CCC(CC2)C3=CC=C(C=C3)C#N)NC(=O)NC4CCOC4	IC50 ~ 50000 nM	Poor binder
T16514	Fatty acid synthase	BPXV31	4-[1-[5-[5-(Methoxymethyl)-1H-1,2,4-triazol-3-yl]-4-methyl-2-propan-2-ylbenzoyl]piperidin-4-yl]benzonitrile	Investigative	68289075	C27H31N5O2	457.6	CC1=CC(=C(C=C1C2=NNC(=N2)COC)C(=O)N3CCC(CC3)C4=CC=C(C=C4)C#N)C(C)C	IC50 ~ 50000 nM	Poor binder
T16514	Fatty acid synthase	BQ9WV4	1-[5-[4-(4-Cyanophenyl)piperidine-1-carbonyl]pyridazin-3-yl]-3-(2-methoxyethyl)urea	Investigative	70872501	C21H24N6O3	408.5	COCCNC(=O)NC1=NN=CC(=C1)C(=O)N2CCC(CC2)C3=CC=C(C=C3)C#N	IC50 ~ 50000 nM	Poor binder
T16514	Fatty acid synthase	BQN2S5	2-Amino-4-[(2S,3S,4R,5R)-5-(6-amino-purin-9-yl)-3,4-dihydroxy-tetrahydro-furan-2-ylmethanesulfonyl]-butyric acid	Investigative	15788084	C14H20N6O7S	416.41	C1=NC(=C2C(=N1)N(C=N2)[C@H]3[C@@H]([C@@H]([C@H](O3)CS(=O)(=O)CC[C@@H](C(=O)O)N)O)O)N	Ki = 100000 nM	Poor binder
T16514	Fatty acid synthase	BSG42X	N-[5-[4-(4-Cyanophenyl)piperidine-1-carbonyl]-1-methylpyrazol-3-yl]-6-(2-methylpropylamino)pyridine-3-carboxamide	Investigative	70872646	C27H31N7O2	485.6	CC(C)CNC1=NC=C(C=C1)C(=O)NC2=NN(C(=C2)C(=O)N3CCC(CC3)C4=CC=C(C=C4)C#N)C	IC50 ~ 50000 nM	Poor binder
T16514	Fatty acid synthase	BTW36E	5-[4-(4-Cyanophenyl)piperidine-1-carbonyl]-2-methyl-N-(piperidin-4-ylmethyl)benzamide	Investigative	68352712	C27H32N4O2	444.6	CC1=C(C=C(C=C1)C(=O)N2CCC(CC2)C3=CC=C(C=C3)C#N)C(=O)NCC4CCNCC4	IC50 ~ 50000 nM	Poor binder
T16514	Fatty acid synthase	BU20DI	Albaspidin PB	Investigative	25096732	C24H30O8	446.5	CCCC(=O)C1=C(C(=C(C(C1=O)(C)C)O)CC2=C(C(C(=O)C(=C2O)C(=O)CC)(C)C)O)O	IC50 = 56100 nM	Poor binder
T16514	Fatty acid synthase	BU3O2V	4-[1-[3-[5-(Methoxymethyl)-1H-1,2,4-triazol-3-yl]benzoyl]piperidin-4-yl]benzonitrile	Investigative	68289034	C23H23N5O2	401.5	COCC1=NC(=NN1)C2=CC(=CC=C2)C(=O)N3CCC(CC3)C4=CC=C(C=C4)C#N	IC50 ~ 50000 nM	Poor binder
T16514	Fatty acid synthase	BU80WD	4-[1-[3-(3,5-Dimethyl-1H-pyrazol-4-yl)benzoyl]azetidin-3-yl]benzonitrile	Investigative	90030011	C22H20N4O	356.4	CC1=C(C(=NN1)C)C2=CC(=CC=C2)C(=O)N3CC(C3)C4=CC=C(C=C4)C#N	IC50 = 50000 nM	Poor binder
T16514	Fatty acid synthase	BUC49X	N-[5-[4-(4-Cyanophenyl)piperidine-1-carbonyl]-2-methylpyrazol-3-yl]-6-(2-methylpropylamino)pyridine-3-carboxamide	Investigative	70872525	C27H31N7O2	485.6	CC(C)CNC1=NC=C(C=C1)C(=O)NC2=CC(=NN2C)C(=O)N3CCC(CC3)C4=CC=C(C=C4)C#N	IC50 ~ 50000 nM	Poor binder
T16514	Fatty acid synthase	BUQ15N	N-[4-[4-(4-Cyanophenyl)piperidine-1-carbonyl]pyridin-2-yl]pyrrolidine-1-carboxamide	Investigative	68289180	C23H25N5O2	403.5	C1CCN(C1)C(=O)NC2=NC=CC(=C2)C(=O)N3CCC(CC3)C4=CC=C(C=C4)C#N	IC50 ~ 50000 nM	Poor binder
T16514	Fatty acid synthase	BW6MO8	2-Amino-4-[(2S,3S,4R,5R)-5-(6-amino-purin-9-yl)-3,4-dihydroxy-tetrahydro-furan-2-ylmethanesulfinyl]-butyric acid	Investigative	10092378	C14H20N6O6S	400.41	C1=NC(=C2C(=N1)N(C=N2)[C@H]3[C@@H]([C@@H]([C@H](O3)CS(=O)CC[C@@H](C(=O)O)N)O)O)N	Ki = 50000 nM	Poor binder
T16514	Fatty acid synthase	BWK63U	4-[1-[3-(1H-Imidazo[4,5-b]pyridin-2-ylamino)-4-methylbenzoyl]piperidin-4-yl]benzonitrile	Investigative	70872451	C26H24N6O	436.5	CC1=C(C=C(C=C1)C(=O)N2CCC(CC2)C3=CC=C(C=C3)C#N)NC4=NC5=C(N4)C=CC=N5	IC50 ~ 50000 nM	Poor binder
T16514	Fatty acid synthase	BWT98Y	1-[5-[4-(4-Cyanophenyl)piperidine-1-carbonyl]-2-methylpyrazol-3-yl]-3-propan-2-ylurea	Investigative	68352667	C21H26N6O2	394.5	CC(C)NC(=O)NC1=CC(=NN1C)C(=O)N2CCC(CC2)C3=CC=C(C=C3)C#N	IC50 ~ 50000 nM	Poor binder
T16514	Fatty acid synthase	BXLM60	4-[1-[2,4-Dimethyl-5-[5-(oxetan-3-ylmethyl)-1H-1,2,4-triazol-3-yl]benzoyl]piperidin-4-yl]benzonitrile	Investigative	68288925	C27H29N5O2	455.6	CC1=CC(=C(C=C1C2=NNC(=N2)CC3COC3)C(=O)N4CCC(CC4)C5=CC=C(C=C5)C#N)C	IC50 ~ 50000 nM	Poor binder
T16514	Fatty acid synthase	BY7DT6	4-[1-[3-[[5-(Dimethylamino)-1H-imidazo[4,5-b]pyridin-2-yl]amino]-4-methylbenzoyl]piperidin-4-yl]benzonitrile	Investigative	70872294	C28H29N7O	479.6	CC1=C(C=C(C=C1)C(=O)N2CCC(CC2)C3=CC=C(C=C3)C#N)NC4=NC5=C(N4)C=CC(=N5)N(C)C	IC50 ~ 50000 nM	Poor binder
T16514	Fatty acid synthase	BZ3YB1	[3-(2,5-Dimethyl-1H-imidazol-4-yl)-4-methylphenyl]-[4-([1,2,4]triazolo[4,3-a]pyridin-7-yl)piperidin-1-yl]methanone	Investigative	90030559	C24H26N6O	414.5	CC1=C(C=C(C=C1)C(=O)N2CCC(CC2)C3=CC4=NN=CN4C=C3)C5=C(NC(=N5)C)C	IC50 = 50000 nM	Poor binder
T16514	Fatty acid synthase	BZ7TA5	Schembl21318035	Investigative	70872253	C25H27N7O2	457.5	CC(C)NC1=NC=C(C=C1)C(=O)NC2=NNC(=C2)C(=O)N3CCC(CC3)C4=CC=C(C=C4)C#N	IC50 ~ 50000 nM	Poor binder
T16514	Fatty acid synthase	BZBK25	2-Cyclobutyl-5-(4-imidazo[1,2-a]pyridin-7-ylpiperidine-1-carbonyl)-N,4-dimethylbenzamide	Investigative	90066766	C26H30N4O2	430.5	CC1=CC(=C(C=C1C(=O)N2CCC(CC2)C3=CC4=NC=CN4C=C3)C(=O)NC)C5CCC5	IC50 = 50000 nM	Poor binder
T16514	Fatty acid synthase	D09CLP	(L-)-S-adenosyl-L-homocysteine	Investigative	439155	C14H20N6O5S	384.41	C1=NC(=C2C(=N1)N(C=N2)[C@H]3[C@@H]([C@@H]([C@H](O3)CSCC[C@@H](C(=O)O)N)O)O)N	Ki = 150000 nM	Poor binder