TTD_Target_ID	Target_Name	TTD_Drug_ID	Drug_Name	Drug_Highest_Status	Drug_PubchemID	Molecular_Formula	Molecular_Weight	Canonical_SMILES	Activity	Binder_Type
T16739	Lysine-specific histone demethylase 1	D0E7PQ	Vorinostat	Approved	5311	C14H20N2O3	264.32	C1=CC=C(C=C1)NC(=O)CCCCCCC(=O)NO	IC50 ~ 100000 nM	Poor binder
T16739	Lysine-specific histone demethylase 1	B09JNS	[1-[(4-Methylphenyl)methyl]triazol-4-yl]methyl 4-methylpiperazine-1-carbodithioate	Investigative	72713759	C17H23N5S2	361.5	CC1=CC=C(C=C1)CN2C=C(N=N2)CSC(=S)N3CCN(CC3)C	IC50 ~ 125000 nM	Poor binder
T16739	Lysine-specific histone demethylase 1	B0GE4R	4-Phenyl-2-prop-2-ynylsulfanyl-6-[3-(trifluoromethyl)anilino]pyrimidine-5-carbonitrile	Investigative	118713037	C21H13F3N4S	410.4	C#CCSC1=NC(=C(C(=N1)NC2=CC=CC(=C2)C(F)(F)F)C#N)C3=CC=CC=C3	IC50 ~ 125000 nM	Poor binder
T16739	Lysine-specific histone demethylase 1	B0JYM4	[1-[(2-Chlorophenyl)methyl]triazol-4-yl]methyl piperazine-1-carbodithioate	Investigative	71652980	C15H18ClN5S2	367.9	C1CN(CCN1)C(=S)SCC2=CN(N=N2)CC3=CC=CC=C3Cl	IC50 ~ 125000 nM	Poor binder
T16739	Lysine-specific histone demethylase 1	B0RZQ6	[1-[(4-Methylphenyl)methyl]triazol-4-yl]methyl morpholine-4-carbodithioate	Investigative	72713113	C16H20N4OS2	348.5	CC1=CC=C(C=C1)CN2C=C(N=N2)CSC(=S)N3CCOCC3	IC50 ~ 125000 nM	Poor binder
T16739	Lysine-specific histone demethylase 1	B0VX3J	Tert-butyl 4-[[1-(4-methylphenyl)triazol-4-yl]methylsulfanylcarbothioyl]piperazine-1-carboxylate	Investigative	71653425	C20H27N5O2S2	433.6	CC1=CC=C(C=C1)N2C=C(N=N2)CSC(=S)N3CCN(CC3)C(=O)OC(C)(C)C	IC50 ~ 125000 nM	Poor binder
T16739	Lysine-specific histone demethylase 1	B10NSQ	1-(4-Acetyl-1,3-thiazol-2-yl)-3-phenylurea	Investigative	64545027	C12H11N3O2S	261.3	CC(=O)C1=CSC(=N1)NC(=O)NC2=CC=CC=C2	IC50 ~ 188000 nM	Poor binder
T16739	Lysine-specific histone demethylase 1	B1A9JW	[1-[(3,4,5-Trimethoxyphenyl)methyl]triazol-4-yl]methyl piperazine-1-carbodithioate	Investigative	71653123	C18H25N5O3S2	423.6	COC1=CC(=CC(=C1OC)OC)CN2C=C(N=N2)CSC(=S)N3CCNCC3	IC50 ~ 125000 nM	Poor binder
T16739	Lysine-specific histone demethylase 1	B1GTV2	N-[4-(4-Chlorophenyl)-1,3-thiazol-2-yl]methanesulfonamide	Investigative	76314915	C10H9ClN2O2S2	288.8	CS(=O)(=O)NC1=NC(=CS1)C2=CC=C(C=C2)Cl	IC50 ~ 188000 nM	Poor binder
T16739	Lysine-specific histone demethylase 1	B1RNJ0	[1-[(4-Fluorophenyl)methyl]triazol-4-yl]methyl morpholine-4-carbodithioate	Investigative	72714195	C15H17FN4OS2	352.5	C1COCCN1C(=S)SCC2=CN(N=N2)CC3=CC=C(C=C3)F	IC50 ~ 125000 nM	Poor binder
T16739	Lysine-specific histone demethylase 1	B1WOD6	Oc1ccc(Cl)cc1Nc1nc2cc(ccc2[nH]1)S(=O)(=O)N1CCOCC1	Investigative	117926025	C17H17ClN4O4S	408.9	C1COCCN1S(=O)(=O)C2=CC3=C(C=C2)N=C(N3)NC4=C(C=CC(=C4)Cl)O	IC50 = 90000 nM	Poor binder
T16739	Lysine-specific histone demethylase 1	B1Y0VS	Benzyl 4-[[1-[(2-chlorophenyl)methyl]triazol-4-yl]methylsulfanylcarbothioyl]piperazine-1-carboxylate	Investigative	71653126	C23H24ClN5O2S2	502.1	C1CN(CCN1C(=O)OCC2=CC=CC=C2)C(=S)SCC3=CN(N=N3)CC4=CC=CC=C4Cl	IC50 = 53200 nM	Poor binder
T16739	Lysine-specific histone demethylase 1	B1YH7D	N-(4-Acetyl-1,3-thiazol-2-yl)benzamide	Investigative	24632452	C12H10N2O2S	246.29	CC(=O)C1=CSC(=N1)NC(=O)C2=CC=CC=C2	IC50 ~ 188000 nM	Poor binder
T16739	Lysine-specific histone demethylase 1	B26SVY	Tert-butyl 4-[[1-(naphthalen-2-ylmethyl)triazol-4-yl]methylsulfanylcarbothioyl]piperazine-1-carboxylate	Investigative	72713538	C24H29N5O2S2	483.7	CC(C)(C)OC(=O)N1CCN(CC1)C(=S)SCC2=CN(N=N2)CC3=CC4=CC=CC=C4C=C3	IC50 ~ 125000 nM	Poor binder
T16739	Lysine-specific histone demethylase 1	B2KGF6	Tert-butyl 4-[[1-[(2-methylphenyl)methyl]triazol-4-yl]methylsulfanylcarbothioyl]piperazine-1-carboxylate	Investigative	72713116	C21H29N5O2S2	447.6	CC1=CC=CC=C1CN2C=C(N=N2)CSC(=S)N3CCN(CC3)C(=O)OC(C)(C)C	IC50 ~ 125000 nM	Poor binder
T16739	Lysine-specific histone demethylase 1	B2KY3P	1-[2-(3-Chloroanilino)-1,3-thiazol-4-yl]ethanone	Investigative	76333040	C11H9ClN2OS	252.72	CC(=O)C1=CSC(=N1)NC2=CC(=CC=C2)Cl	IC50 = 123000 nM	Poor binder
T16739	Lysine-specific histone demethylase 1	B2NXU0	1-[2-(4-Chloroanilino)-1,3-thiazol-4-yl]ethanone	Investigative	2744807	C11H9ClN2OS	252.72	CC(=O)C1=CSC(=N1)NC2=CC=C(C=C2)Cl	IC50 = 121000 nM	Poor binder
T16739	Lysine-specific histone demethylase 1	B2OM0B	Tert-butyl 4-[[1-[(4-hydroxyphenyl)methyl]triazol-4-yl]methylsulfanylcarbothioyl]piperazine-1-carboxylate	Investigative	72713319	C20H27N5O3S2	449.6	CC(C)(C)OC(=O)N1CCN(CC1)C(=S)SCC2=CN(N=N2)CC3=CC=C(C=C3)O	IC50 = 70700 nM	Poor binder
T16739	Lysine-specific histone demethylase 1	B38BWP	[1-[(2,6-Difluorophenyl)methyl]triazol-4-yl]methyl piperazine-1-carbodithioate	Investigative	71760961	C15H17F2N5S2	369.5	C1CN(CCN1)C(=S)SCC2=CN(N=N2)CC3=C(C=CC=C3F)F	IC50 ~ 125000 nM	Poor binder
T16739	Lysine-specific histone demethylase 1	B39LYE	4-(4-Nitroanilino)-6-phenyl-2-prop-2-ynylsulfanylpyrimidine-5-carbonitrile	Investigative	118733311	C20H13N5O2S	387.4	C#CCSC1=NC(=C(C(=N1)NC2=CC=C(C=C2)[N+](=O)[O-])C#N)C3=CC=CC=C3	IC50 = 123310.48 nM	Poor binder
T16739	Lysine-specific histone demethylase 1	B3D5SA	(2S)-N-[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-6-Amino-1-[(2S)-2-[[(2S)-1-amino-6-[(2-hydroxyacetyl)amino]-1-oxohexan-2-yl]carbamoyl]pyrrolidin-1-yl]-1-oxohexan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]-1-(2-hydroxyacetyl)pyrrolidine-2-carboxamide	Investigative	134131047	C61H103N19O15	1342.6	CC(C)C[C@@H](C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCCNC(=O)CO)C(=O)N)NC(=O)[C@H](CC2=CC=CC=C2)NC(=O)[C@H](CO)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H]3CCCN3C(=O)CO	Ki = 190000 nM	Poor binder
T16739	Lysine-specific histone demethylase 1	B3TQN7	4-(3-Chloroanilino)-6-phenyl-2-prop-2-ynylsulfanylpyrimidine-5-carbonitrile	Investigative	118713040	C20H13ClN4S	376.9	C#CCSC1=NC(=C(C(=N1)NC2=CC(=CC=C2)Cl)C#N)C3=CC=CC=C3	IC50 ~ 125000 nM	Poor binder
T16739	Lysine-specific histone demethylase 1	B3V5HS	N-Cyclopropyl-4-[2-(4-methylphenyl)-5-(piperidin-4-ylmethoxy)pyridin-3-yl]benzamide	Investigative	127028982	C28H31N3O2	441.6	CC1=CC=C(C=C1)C2=C(C=C(C=N2)OCC3CCNCC3)C4=CC=C(C=C4)C(=O)NC5CC5	Ki ~ 50000 nM	Poor binder
T16739	Lysine-specific histone demethylase 1	B3W8VA	4-(Tert-Butoxycarbonyl)piperazine-1-dithiocarboxylic acid 1-(7-hydroxycoumarin-3-ylmethyl)-1H-1,2,3-triazole-4-ylmethyl ester	Investigative	73055636	C23H27N5O5S2	517.6	CC(C)(C)OC(=O)N1CCN(CC1)C(=S)SCC2=CN(N=N2)CC3=CC4=C(C=C(C=C4)O)OC3=O	IC50 = 102560 nM	Poor binder
T16739	Lysine-specific histone demethylase 1	B48UWN	N-[4-(4-Chlorophenyl)-1,3-thiazol-2-yl]-1-phenylmethanesulfonamide	Investigative	76333044	C16H13ClN2O2S2	364.9	C1=CC=C(C=C1)CS(=O)(=O)NC2=NC(=CS2)C3=CC=C(C=C3)Cl	IC50 ~ 188000 nM	Poor binder
T16739	Lysine-specific histone demethylase 1	B49AQR	[1-[(4-Methylphenyl)methyl]triazol-4-yl]methyl 4-(2-hydroxyethyl)piperazine-1-carbodithioate	Investigative	72713972	C18H25N5OS2	391.6	CC1=CC=C(C=C1)CN2C=C(N=N2)CSC(=S)N3CCN(CC3)CCO	IC50 = 83400 nM	Poor binder
T16739	Lysine-specific histone demethylase 1	B4FX9P	Tert-butyl 4-[[1-[[2-(trifluoromethyl)phenyl]methyl]triazol-4-yl]methylsulfanylcarbothioyl]piperazine-1-carboxylate	Investigative	71616470	C21H26F3N5O2S2	501.6	CC(C)(C)OC(=O)N1CCN(CC1)C(=S)SCC2=CN(N=N2)CC3=CC=CC=C3C(F)(F)F	IC50 ~ 125000 nM	Poor binder
T16739	Lysine-specific histone demethylase 1	B4HO5V	1-[2-(3-Hydroxyanilino)-1,3-thiazol-4-yl]ethanone	Investigative	76318528	C11H10N2O2S	234.28	CC(=O)C1=CSC(=N1)NC2=CC(=CC=C2)O	IC50 ~ 188000 nM	Poor binder
T16739	Lysine-specific histone demethylase 1	B4LIR8	[1-[(4-Methylphenyl)methyl]triazol-4-yl]methyl 4-ethylpiperazine-1-carbodithioate	Investigative	72713762	C18H25N5S2	375.6	CCN1CCN(CC1)C(=S)SCC2=CN(N=N2)CC3=CC=C(C=C3)C	IC50 ~ 125000 nM	Poor binder
T16739	Lysine-specific histone demethylase 1	B4PWG9	[1-[[4-(Trifluoromethyl)phenyl]methyl]triazol-4-yl]methyl piperazine-1-carbodithioate	Investigative	72713325	C16H18F3N5S2	401.5	C1CN(CCN1)C(=S)SCC2=CN(N=N2)CC3=CC=C(C=C3)C(F)(F)F	IC50 = 87400 nM	Poor binder
T16739	Lysine-specific histone demethylase 1	B54INS	4-(4-Bromophenyl)-6-(4-chloroanilino)-2-prop-2-ynylsulfanylpyrimidine-5-carbonitrile	Investigative	118733315	C20H12BrClN4S	455.8	C#CCSC1=NC(=C(C(=N1)NC2=CC=C(C=C2)Cl)C#N)C3=CC=C(C=C3)Br	IC50 ~ 125000 nM	Poor binder
T16739	Lysine-specific histone demethylase 1	B54QJD	(1R,2S)-2-(2-Phenylphenyl)cyclopropan-1-amine;hydrochloride	Investigative	56666983	C15H16ClN	245.74	C1[C@H]([C@@H]1N)C2=CC=CC=C2C3=CC=CC=C3.Cl	Ki ~ 100000 nM	Poor binder
T16739	Lysine-specific histone demethylase 1	B58VSJ	4-Chloro-6-(4-chlorophenyl)-2-[[1-[(2-chlorophenyl)methyl]triazol-4-yl]methylsulfanyl]pyrimidine-5-carbonitrile	Investigative	118733320	C21H13Cl3N6S	487.8	C1=CC=C(C(=C1)CN2C=C(N=N2)CSC3=NC(=C(C(=N3)Cl)C#N)C4=CC=C(C=C4)Cl)Cl	IC50 = 125000 nM	Poor binder
T16739	Lysine-specific histone demethylase 1	B5B8QT	(2S)-2-[[(2S)-6-Amino-2-[[(2S)-2-[[(2S)-1-[(2S)-2-[[(2S)-6-amino-2-[[2-[[2-[[(2S,3R)-2-[[(2S)-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[(2S,3R)-2-[[(2S)-5-amino-2-[[(2S)-2-[[(2S,3R)-2-[[(2S)-5-carbamimidamido-2-[(2-hydroxyacetyl)amino]pentanoyl]amino]-3-hydroxybutanoyl]amino]-4-methylsulfanylbutanoyl]amino]-5-oxopentanoyl]amino]-3-hydroxybutanoyl]amino]propanoyl]amino]-5-carbamimidamidopentanoyl]amino]hexanoyl]amino]-3-hydroxypropanoyl]amino]-3-hydroxybutanoyl]amino]acetyl]amino]acetyl]amino]hexanoyl]amino]propanoyl]pyrrolidine-2-carbonyl]amino]-5-carbamimidamidopentanoyl]amino]hexanoyl]amino]-N-[(2S)-1-amino-4-methyl-1-oxopentan-2-yl]pentanediamide	Investigative	137645494	C89H162N34O27S	2172.5	C[C@H]([C@@H](C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CC(C)C)C(=O)N)NC(=O)[C@H](CCC(=O)N)NC(=O)[C@H](CCSC)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)CO)O	Ki = 170000 nM	Poor binder
T16739	Lysine-specific histone demethylase 1	B5BMG4	[1-[(2-Chlorophenyl)methyl]triazol-4-yl]methyl 4-methylpiperazine-1-carbodithioate	Investigative	72713761	C16H20ClN5S2	381.9	CN1CCN(CC1)C(=S)SCC2=CN(N=N2)CC3=CC=CC=C3Cl	IC50 ~ 125000 nM	Poor binder
T16739	Lysine-specific histone demethylase 1	B5EZ3N	Tert-butyl 4-[[1-(2-oxochromen-4-yl)triazol-4-yl]methylsulfanylcarbothioyl]piperazine-1-carboxylate	Investigative	72713542	C22H25N5O4S2	487.6	CC(C)(C)OC(=O)N1CCN(CC1)C(=S)SCC2=CN(N=N2)C3=CC(=O)OC4=CC=CC=C43	IC50 ~ 125000 nM	Poor binder
T16739	Lysine-specific histone demethylase 1	B5F1BI	3-Chloro-N-[4-(2-nitrophenyl)-1,3-thiazol-2-yl]benzenesulfonamide	Investigative	76329400	C15H10ClN3O4S2	395.8	C1=CC=C(C(=C1)C2=CSC(=N2)NS(=O)(=O)C3=CC(=CC=C3)Cl)[N+](=O)[O-]	IC50 = 61600 nM	Poor binder
T16739	Lysine-specific histone demethylase 1	B5NO1G	[1-[(2-Fluorophenyl)methyl]triazol-4-yl]methyl 4-ethylpiperazine-1-carbodithioate	Investigative	72713763	C17H22FN5S2	379.5	CCN1CCN(CC1)C(=S)SCC2=CN(N=N2)CC3=CC=CC=C3F	IC50 ~ 125000 nM	Poor binder
T16739	Lysine-specific histone demethylase 1	B5SFY6	Tert-butyl 4-[[1-[(2,4-dihydroxyphenyl)methyl]triazol-4-yl]methylsulfanylcarbothioyl]piperazine-1-carboxylate	Investigative	72713322	C20H27N5O4S2	465.6	CC(C)(C)OC(=O)N1CCN(CC1)C(=S)SCC2=CN(N=N2)CC3=C(C=C(C=C3)O)O	IC50 = 81300 nM	Poor binder
T16739	Lysine-specific histone demethylase 1	B63DQM	2-(4-Methylphenyl)-5-(piperidin-4-ylmethoxy)-3-[4-(piperidin-1-ylmethyl)phenyl]pyridine	Investigative	127024904	C30H37N3O	455.6	CC1=CC=C(C=C1)C2=C(C=C(C=N2)OCC3CCNCC3)C4=CC=C(C=C4)CN5CCCCC5	Ki ~ 50000 nM	Poor binder
T16739	Lysine-specific histone demethylase 1	B64SIV	[1-[(2-Fluorophenyl)methyl]triazol-4-yl]methyl 4-methylpiperazine-1-carbodithioate	Investigative	72713758	C16H20FN5S2	365.5	CN1CCN(CC1)C(=S)SCC2=CN(N=N2)CC3=CC=CC=C3F	IC50 ~ 125000 nM	Poor binder
T16739	Lysine-specific histone demethylase 1	B6GK8X	[1-[(4-Fluorophenyl)methyl]triazol-4-yl]methyl 4-(2-hydroxyethyl)piperazine-1-carbodithioate	Investigative	72713974	C17H22FN5OS2	395.5	C1CN(CCN1CCO)C(=S)SCC2=CN(N=N2)CC3=CC=C(C=C3)F	IC50 ~ 125000 nM	Poor binder
T16739	Lysine-specific histone demethylase 1	B6L4XW	Tert-butyl 4-[[1-[(5-oxo-2H-furan-3-yl)methyl]triazol-4-yl]methylsulfanylcarbothioyl]piperazine-1-carboxylate	Investigative	72713541	C18H25N5O4S2	439.6	CC(C)(C)OC(=O)N1CCN(CC1)C(=S)SCC2=CN(N=N2)CC3=CC(=O)OC3	IC50 ~ 125000 nM	Poor binder
T16739	Lysine-specific histone demethylase 1	B6N9FX	[1-[(2-Fluorophenyl)methyl]triazol-4-yl]methyl morpholine-4-carbodithioate	Investigative	72714194	C15H17FN4OS2	352.5	C1COCCN1C(=S)SCC2=CN(N=N2)CC3=CC=CC=C3F	IC50 ~ 125000 nM	Poor binder
T16739	Lysine-specific histone demethylase 1	B6U2CB	4-(Tert-Butoxycarbonyl)piperazine-1-dithiocarboxylic acid 1-(coumarin-3-ylmethyl)-1H-1,2,3-triazole-4-ylmethyl ester	Investigative	76336591	C23H27N5O4S2	501.6	CC(C)(C)OC(=O)N1CCN(CC1)C(=S)SCC2=CN(N=N2)CC3=CC4=CC=CC=C4OC3=O	IC50 ~ 125000 nM	Poor binder
T16739	Lysine-specific histone demethylase 1	B6X5UY	4-(4-Chloroanilino)-6-phenyl-2-prop-2-ynylsulfanylpyrimidine-5-carbonitrile	Investigative	118713039	C20H13ClN4S	376.9	C#CCSC1=NC(=C(C(=N1)NC2=CC=C(C=C2)Cl)C#N)C3=CC=CC=C3	IC50 = 125000 nM	Poor binder
T16739	Lysine-specific histone demethylase 1	B76LVC	4'-(Methoxycarbonyl)-[2,2'-bipyridine]-4-carboxylic acid	Investigative	25138011	C13H10N2O4	258.23	COC(=O)C1=CC(=NC=C1)C2=NC=CC(=C2)C(=O)O	IC50 ~ 100000 nM	Poor binder
T16739	Lysine-specific histone demethylase 1	B7FUC2	N-[4-(4-Chlorophenyl)-1,3-thiazol-2-yl]-N,4-dimethylbenzenesulfonamide	Investigative	76318531	C17H15ClN2O2S2	378.9	CC1=CC=C(C=C1)S(=O)(=O)N(C)C2=NC(=CS2)C3=CC=C(C=C3)Cl	IC50 ~ 188000 nM	Poor binder
T16739	Lysine-specific histone demethylase 1	B7IB0U	(2S)-2-[[(2S)-2-[[(2S)-5-Amino-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-1-[(2S)-2-[[(2S)-6-amino-2-[[2-[[2-[[(2S,3S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S,3S)-2-[[(2S)-5-amino-2-[[(2S)-6-amino-2-[[(2S,3S)-2-[[(2S)-2-[[(2R)-2-aminopropanoyl]amino]-5-carbamimidamidopentanoyl]amino]-3-hydroxybutanoyl]amino]hexanoyl]amino]-5-oxopentanoyl]amino]-3-hydroxybutanoyl]amino]propanoyl]amino]-5-carbamimidamidopentanoyl]amino]-6-(2,5-dihydropyrrol-1-yl)hexanoyl]amino]-3-hydroxypropanoyl]amino]-3-hydroxybutanoyl]amino]acetyl]amino]acetyl]amino]hexanoyl]amino]propanoyl]pyrrolidine-2-carbonyl]amino]-5-carbamimidamidopentanoyl]amino]hexanoyl]amino]-5-oxopentanoyl]amino]-4-methylpentanoyl]amino]propanoic acid	Investigative	118728857	C98H176N36O28	2306.7	C[C@@H]([C@@H](C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN1CC=CC1)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@H](C)O)C(=O)NCC(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)O)NC(=O)[C@H](CCC(=O)N)NC(=O)[C@H](CCCCN)NC(=O)[C@H]([C@H](C)O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](C)N)O	IC50 ~ 100000 nM	Poor binder
T16739	Lysine-specific histone demethylase 1	B7JRV8	Chembl4299336	Investigative	145948688	C111H180N36O29	2482.8	CC(C)C[C@@H](C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](CO)C(=O)N[C@H](CC(=O)O)C(=O)N2CCC[C@@H]2C(=O)N[C@H](CC(=O)N)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@H](CCCCN)C(=O)N3CCC[C@@H]3C(=O)N[C@@H](CC(=O)N)C(=O)N[C@H](CC4=CC=C(C=C4)O)C(=O)N[C@H](CO)C(=O)N[C@H](CCC(=O)N)C(=O)N)NC(=O)[C@H](CCCCN[C@H]5C[C@@H]5C6=CC=CC=C6)NC(=O)[C@H](CO)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]7CCCN7	IC50 = 63000 nM	Poor binder
T16739	Lysine-specific histone demethylase 1	B7O5MW	Parnate	Investigative	19493	C9H11N	133.19	C1[C@H]([C@@H]1N)C2=CC=CC=C2	IC50 = 80700 nM	Poor binder
T16739	Lysine-specific histone demethylase 1	B7UQJ6	[1-[(4-Fluorophenyl)methyl]triazol-4-yl]methyl piperidine-1-carbodithioate	Investigative	72714189	C16H19FN4S2	350.5	C1CCN(CC1)C(=S)SCC2=CN(N=N2)CC3=CC=C(C=C3)F	IC50 ~ 125000 nM	Poor binder
T16739	Lysine-specific histone demethylase 1	B8DG6J	2-Prop-2-ynylsulfanyl-4-[3-(trifluoromethyl)anilino]-6-(3,4,5-trimethoxyphenyl)pyrimidine-5-carbonitrile	Investigative	118733317	C24H19F3N4O3S	500.5	COC1=CC(=CC(=C1OC)OC)C2=C(C(=NC(=N2)SCC#C)NC3=CC=CC(=C3)C(F)(F)F)C#N	IC50 ~ 125000 nM	Poor binder
T16739	Lysine-specific histone demethylase 1	B8GC5L	1-(6-Bromonaphthalen-2-yl)oxy-3-(cyclopropylamino)propan-2-ol	Investigative	43343228	C16H18BrNO2	336.22	C1CC1NCC(COC2=CC3=C(C=C2)C=C(C=C3)Br)O	IC50 = 111400 nM	Poor binder
T16739	Lysine-specific histone demethylase 1	B8GL1F	[4-[2-(4-Methylphenyl)-5-(piperidin-4-ylmethoxy)pyridin-3-yl]phenyl]-piperazin-1-ylmethanone	Investigative	127024902	C29H34N4O2	470.6	CC1=CC=C(C=C1)C2=C(C=C(C=N2)OCC3CCNCC3)C4=CC=C(C=C4)C(=O)N5CCNCC5	Ki ~ 50000 nM	Poor binder
T16739	Lysine-specific histone demethylase 1	B8MF1B	[4-[2-(4-Methylphenyl)-5-(piperidin-4-ylmethoxy)pyridin-3-yl]phenyl]methanol	Investigative	127026390	C25H28N2O2	388.5	CC1=CC=C(C=C1)C2=C(C=C(C=N2)OCC3CCNCC3)C4=CC=C(C=C4)CO	Ki ~ 50000 nM	Poor binder
T16739	Lysine-specific histone demethylase 1	B8N2WX	N-[3-[3-(Prop-2-ynylamino)propoxy]phenyl]benzamide	Investigative	73334584	C19H20N2O2	308.4	C#CCNCCCOC1=CC=CC(=C1)NC(=O)C2=CC=CC=C2	IC50 = 184200 nM	Poor binder
T16739	Lysine-specific histone demethylase 1	B8PC4G	N-(4-Fluorophenyl)-2-[[(1S,2R)-2-phenylcyclopropyl]amino]acetamide	Investigative	90654144	C17H17FN2O	284.33	C1[C@@H]([C@H]1NCC(=O)NC2=CC=C(C=C2)F)C3=CC=CC=C3	Ki ~ 50000 nM	Poor binder
T16739	Lysine-specific histone demethylase 1	B8T3LF	Benzyl 4-[[1-[(4-chlorophenyl)methyl]triazol-4-yl]methylsulfanylcarbothioyl]piperazine-1-carboxylate	Investigative	71653266	C23H24ClN5O2S2	502.1	C1CN(CCN1C(=O)OCC2=CC=CC=C2)C(=S)SCC3=CN(N=N3)CC4=CC=C(C=C4)Cl	IC50 ~ 125000 nM	Poor binder
T16739	Lysine-specific histone demethylase 1	B8Y4NS	N-[1-(4-Chlorophenyl)pyrazol-3-yl]-3-(trifluoromethyl)benzenesulfonamide	Investigative	76333049	C16H11ClF3N3O2S	401.8	C1=CC(=CC(=C1)S(=O)(=O)NC2=NN(C=C2)C3=CC=C(C=C3)Cl)C(F)(F)F	IC50 = 56900 nM	Poor binder
T16739	Lysine-specific histone demethylase 1	B92TIE	(1-Benzyltriazol-4-yl)methyl piperidine-1-carbodithioate	Investigative	72714191	C16H20N4S2	332.5	C1CCN(CC1)C(=S)SCC2=CN(N=N2)CC3=CC=CC=C3	IC50 ~ 125000 nM	Poor binder
T16739	Lysine-specific histone demethylase 1	B93IMX	Tert-butyl 4-[[1-(4-methoxyphenyl)triazol-4-yl]methylsulfanylcarbothioyl]piperazine-1-carboxylate	Investigative	71653427	C20H27N5O3S2	449.6	CC(C)(C)OC(=O)N1CCN(CC1)C(=S)SCC2=CN(N=N2)C3=CC=C(C=C3)OC	IC50 ~ 125000 nM	Poor binder
T16739	Lysine-specific histone demethylase 1	B96RZM	N-(4-Acetyl-1,3-thiazol-2-yl)benzenesulfonamide	Investigative	62999067	C11H10N2O3S2	282.3	CC(=O)C1=CSC(=N1)NS(=O)(=O)C2=CC=CC=C2	IC50 ~ 188000 nM	Poor binder
T16739	Lysine-specific histone demethylase 1	B9CK4T	(1S,2R)-2-(4-Ethoxyphenyl)-2-fluorocyclopropan-1-amine	Investigative	137644507	C11H14FNO	195.23	CCOC1=CC=C(C=C1)[C@@]2(C[C@@H]2N)F	IC50 ~ 50000 nM	Poor binder
T16739	Lysine-specific histone demethylase 1	B9IMF3	4-Chloro-2-(prop-2-yn-1-ylthio)-6-(p-tolyl)pyrimidine-5-carbonitrile	Investigative	87057358	C15H10ClN3S	299.8	CC1=CC=C(C=C1)C2=C(C(=NC(=N2)SCC#C)Cl)C#N	IC50 = 59160 nM	Poor binder
T16739	Lysine-specific histone demethylase 1	B9J8XR	(1S,2R)-2-Fluoro-2-(3-methoxyphenyl)cyclopropan-1-amine	Investigative	137650930	C10H12FNO	181.21	COC1=CC=CC(=C1)[C@@]2(C[C@@H]2N)F	IC50 ~ 50000 nM	Poor binder
T16739	Lysine-specific histone demethylase 1	B9RSC2	4-(Tert-Butoxycarbonyl)piperazine-1-dithiocarboxylic acid 1-(5-methyl-7-hydroxycoumarin-4-ylmethyl)-1H-1,2,3-triazole-4-ylmethyl ester	Investigative	76329344	C24H29N5O5S2	531.7	CC1=CC(=CC2=C1C(=CC(=O)O2)CN3C=C(N=N3)CSC(=S)N4CCN(CC4)C(=O)OC(C)(C)C)O	IC50 ~ 125000 nM	Poor binder
T16739	Lysine-specific histone demethylase 1	B9T4OG	4-Chloro-6-(4-nitrophenyl)-2-prop-2-ynylsulfanylpyrimidine-5-carbonitrile	Investigative	87057359	C14H7ClN4O2S	330.7	C#CCSC1=NC(=C(C(=N1)Cl)C#N)C2=CC=C(C=C2)[N+](=O)[O-]	IC50 = 125000 nM	Poor binder
T16739	Lysine-specific histone demethylase 1	B9VCW8	4-(Tert-Butoxycarbonyl)piperazine-1-dithiocarboxylic acid 1-(6-chlorocoumarin-4-ylmethyl)-1H-1,2,3-triazole-4-ylmethyl ester	Investigative	76336592	C23H26ClN5O4S2	536.1	CC(C)(C)OC(=O)N1CCN(CC1)C(=S)SCC2=CN(N=N2)CC3=CC(=O)OC4=C3C=C(C=C4)Cl	IC50 ~ 125000 nM	Poor binder
T16739	Lysine-specific histone demethylase 1	B9VMC1	Ethyl (1S,2S)-1-amino-2-phenylcyclopropane-1-carboxylate	Investigative	12106307	C12H15NO2	205.25	CCOC(=O)[C@@]1(C[C@H]1C2=CC=CC=C2)N	IC50 ~ 100000 nM	Poor binder
T16739	Lysine-specific histone demethylase 1	BA36ZV	3-Chloro-6-nitro-2-(trifluoromethyl)chromone	Investigative	715694	C10H3ClF3NO4	293.58	C1=CC2=C(C=C1[N+](=O)[O-])C(=O)C(=C(O2)C(F)(F)F)Cl	IC50 = 51000 nM	Poor binder
T16739	Lysine-specific histone demethylase 1	BA6IE1	Tert-butyl 4-[[1-[2-(4-methylphenyl)ethyl]triazol-4-yl]methylsulfanylcarbothioyl]piperazine-1-carboxylate	Investigative	72713323	C22H31N5O2S2	461.6	CC1=CC=C(C=C1)CCN2C=C(N=N2)CSC(=S)N3CCN(CC3)C(=O)OC(C)(C)C	IC50 ~ 125000 nM	Poor binder
T16739	Lysine-specific histone demethylase 1	BACP51	4-(2-Chloroanilino)-6-phenyl-2-prop-2-ynylsulfanylpyrimidine-5-carbonitrile	Investigative	118713038	C20H13ClN4S	376.9	C#CCSC1=NC(=C(C(=N1)NC2=CC=CC=C2Cl)C#N)C3=CC=CC=C3	IC50 ~ 125000 nM	Poor binder
T16739	Lysine-specific histone demethylase 1	BAI4W5	(1S,2R)-2-Fluoro-2-(3-nitrophenyl)cyclopropan-1-amine	Investigative	137657965	C9H9FN2O2	196.18	C1[C@@H]([C@@]1(C2=CC(=CC=C2)[N+](=O)[O-])F)N	IC50 ~ 50000 nM	Poor binder
T16739	Lysine-specific histone demethylase 1	BAN96J	2-[Benzyl-[(1S,2R)-2-phenylcyclopropyl]amino]-N-tert-butylacetamide	Investigative	90654151	C22H28N2O	336.5	CC(C)(C)NC(=O)CN(CC1=CC=CC=C1)[C@H]2C[C@@H]2C3=CC=CC=C3	Ki ~ 100000 nM	Poor binder
T16739	Lysine-specific histone demethylase 1	BAO6K7	(1S,2R)-2-Phenylcyclopropan-1-amine;(1R,2S)-2-phenylcyclopropan-1-amine	Investigative	73417116	C18H22N2	266.4	C1[C@H]([C@@H]1N)C2=CC=CC=C2.C1[C@@H]([C@H]1N)C2=CC=CC=C2	IC50 ~ 100000 nM	Poor binder
T16739	Lysine-specific histone demethylase 1	BB18UF	N-[4-(4-Chlorophenyl)-1,3-thiazol-2-yl]benzenesulfonamide	Investigative	76333043	C15H11ClN2O2S2	350.8	C1=CC=C(C=C1)S(=O)(=O)NC2=NC(=CS2)C3=CC=C(C=C3)Cl	IC50 = 85700 nM	Poor binder
T16739	Lysine-specific histone demethylase 1	BB6K2V	[1-[(2-Fluorophenyl)methyl]triazol-4-yl]methyl 4-(2-hydroxyethyl)piperazine-1-carbodithioate	Investigative	72713973	C17H22FN5OS2	395.5	C1CN(CCN1CCO)C(=S)SCC2=CN(N=N2)CC3=CC=CC=C3F	IC50 = 100100 nM	Poor binder
T16739	Lysine-specific histone demethylase 1	BB74WU	Tert-butyl 4-[[1-[(3-hydroxyphenyl)methyl]triazol-4-yl]methylsulfanylcarbothioyl]piperazine-1-carboxylate	Investigative	72713321	C20H27N5O3S2	449.6	CC(C)(C)OC(=O)N1CCN(CC1)C(=S)SCC2=CN(N=N2)CC3=CC(=CC=C3)O	IC50 = 77100 nM	Poor binder
T16739	Lysine-specific histone demethylase 1	BBR0K9	(1S,2R)-2-Fluoro-2-[3-(pentafluoro-lambda6-sulfanyl)phenyl]cyclopropan-1-amine	Investigative	137644883	C9H9F6NS	277.23	C1[C@@H]([C@@]1(C2=CC(=CC=C2)S(F)(F)(F)(F)F)F)N	IC50 ~ 50000 nM	Poor binder
T16739	Lysine-specific histone demethylase 1	BC30HT	[[5-Cyano-2-[(4-fluorophenyl)methylsulfanyl]-6-(3,4,5-trimethoxyphenyl)pyrimidin-4-yl]amino]thiourea	Investigative	118733322	C22H21FN6O3S2	500.6	COC1=CC(=CC(=C1OC)OC)C2=C(C(=NC(=N2)SCC3=CC=C(C=C3)F)NNC(=S)N)C#N	IC50 = 125000 nM	Poor binder
T16739	Lysine-specific histone demethylase 1	BCY8J1	(1R,2S)-2-(4-Fluorophenyl)cyclopropanamine Hydrochloride	Investigative	56666982	C9H11ClFN	187.64	C1[C@H]([C@@H]1N)C2=CC=C(C=C2)F.Cl	Ki = 79600 nM	Poor binder
T16739	Lysine-specific histone demethylase 1	BDM18K	1-[2-(4-Hydroxyanilino)-1,3-thiazol-4-yl]ethanone	Investigative	76322188	C11H10N2O2S	234.28	CC(=O)C1=CSC(=N1)NC2=CC=C(C=C2)O	IC50 = 57000 nM	Poor binder
T16739	Lysine-specific histone demethylase 1	BDUW63	4-Chloro-2-[[1-[(2-chlorophenyl)methyl]triazol-4-yl]methylsulfanyl]-6-phenylpyrimidine-5-carbonitrile	Investigative	118733319	C21H14Cl2N6S	453.3	C1=CC=C(C=C1)C2=C(C(=NC(=N2)SCC3=CN(N=N3)CC4=CC=CC=C4Cl)Cl)C#N	IC50 = 97274.72 nM	Poor binder
T16739	Lysine-specific histone demethylase 1	BDXM80	N-[3-[3-[Methyl(prop-2-ynyl)amino]propoxy]phenyl]benzamide	Investigative	73334585	C20H22N2O2	322.4	CN(CCCOC1=CC=CC(=C1)NC(=O)C2=CC=CC=C2)CC#C	IC50 = 93100 nM	Poor binder
T16739	Lysine-specific histone demethylase 1	BE58CV	4-[5-Hydroxy-2-(4-methylphenyl)pyridin-3-yl]benzonitrile	Investigative	127025220	C19H14N2O	286.3	CC1=CC=C(C=C1)C2=C(C=C(C=N2)O)C3=CC=C(C=C3)C#N	Ki ~ 50000 nM	Poor binder
T16739	Lysine-specific histone demethylase 1	BEAY71	Tert-butyl 4-[[1-[(6-methyl-2-oxochromen-4-yl)methyl]triazol-4-yl]methylsulfanylcarbothioyl]piperazine-1-carboxylate	Investigative	76318471	C24H29N5O4S2	515.7	CC1=CC2=C(C=C1)OC(=O)C=C2CN3C=C(N=N3)CSC(=S)N4CCN(CC4)C(=O)OC(C)(C)C	IC50 ~ 125000 nM	Poor binder
T16739	Lysine-specific histone demethylase 1	BEM06J	[1-[(3,4-Dichlorophenyl)methyl]triazol-4-yl]methyl piperazine-1-carbodithioate	Investigative	71653122	C15H17Cl2N5S2	402.4	C1CN(CCN1)C(=S)SCC2=CN(N=N2)CC3=CC(=C(C=C3)Cl)Cl	IC50 ~ 125000 nM	Poor binder
T16739	Lysine-specific histone demethylase 1	BEP0O1	[1-[(4-Fluorophenyl)methyl]triazol-4-yl]methyl piperazine-1-carbodithioate	Investigative	71652979	C15H18FN5S2	351.5	C1CN(CCN1)C(=S)SCC2=CN(N=N2)CC3=CC=C(C=C3)F	IC50 = 69300 nM	Poor binder
T16739	Lysine-specific histone demethylase 1	BEU12R	Tert-butyl 4-[[1-(2-fluorophenyl)triazol-4-yl]methylsulfanylcarbothioyl]piperazine-1-carboxylate	Investigative	71616593	C19H24FN5O2S2	437.6	CC(C)(C)OC(=O)N1CCN(CC1)C(=S)SCC2=CN(N=N2)C3=CC=CC=C3F	IC50 ~ 125000 nM	Poor binder
T16739	Lysine-specific histone demethylase 1	BEX84G	Tert-butyl 4-[[1-[(4-nitrophenyl)methyl]triazol-4-yl]methylsulfanylcarbothioyl]piperazine-1-carboxylate	Investigative	72713320	C20H26N6O4S2	478.6	CC(C)(C)OC(=O)N1CCN(CC1)C(=S)SCC2=CN(N=N2)CC3=CC=C(C=C3)[N+](=O)[O-]	IC50 ~ 125000 nM	Poor binder
T16739	Lysine-specific histone demethylase 1	BF1T2R	[1-[(4-Fluorophenyl)methyl]triazol-4-yl]methyl 4-methylsulfonylpiperazine-1-carbodithioate	Investigative	72714201	C16H20FN5O2S3	429.6	CS(=O)(=O)N1CCN(CC1)C(=S)SCC2=CN(N=N2)CC3=CC=C(C=C3)F	IC50 = 55100 nM	Poor binder
T16739	Lysine-specific histone demethylase 1	BF61LR	Chembl4250459	Investigative	145985822	C19H17BrN2O5	433.3	COC1=C(C=C(C=C1)CC2C(=O)NC(=O)N(C2=O)C3=CC=C(C=C3)Br)OC	IC50 ~ 75000 nM	Poor binder
T16739	Lysine-specific histone demethylase 1	BF61RH	Tert-butyl 4-[[1-[(2,6-difluorophenyl)methyl]triazol-4-yl]methylsulfanylcarbothioyl]piperazine-1-carboxylate	Investigative	71616473	C20H25F2N5O2S2	469.6	CC(C)(C)OC(=O)N1CCN(CC1)C(=S)SCC2=CN(N=N2)CC3=C(C=CC=C3F)F	IC50 = 51200 nM	Poor binder
T16739	Lysine-specific histone demethylase 1	BG7W6P	(1S,2S)-2-Fluoro-2-(4-nitrophenyl)cyclopropan-1-amine	Investigative	137645133	C9H9FN2O2	196.18	C1[C@@H]([C@]1(C2=CC=C(C=C2)[N+](=O)[O-])F)N	IC50 ~ 50000 nM	Poor binder
T16739	Lysine-specific histone demethylase 1	BG9B1Q	N-[4-(4-Chloro-phenyl)-thiazol-2-yl]-4-methyl-benzenesulfonamide	Investigative	10666499	C16H13ClN2O2S2	364.9	CC1=CC=C(C=C1)S(=O)(=O)NC2=NC(=CS2)C3=CC=C(C=C3)Cl	IC50 = 50500 nM	Poor binder
T16739	Lysine-specific histone demethylase 1	BGJT18	[1-[(4-Fluorophenyl)methyl]triazol-4-yl]methyl 4-phenylpiperazine-1-carbodithioate	Investigative	72713977	C21H22FN5S2	427.6	C1CN(CCN1C2=CC=CC=C2)C(=S)SCC3=CN(N=N3)CC4=CC=C(C=C4)F	IC50 ~ 125000 nM	Poor binder
T16739	Lysine-specific histone demethylase 1	BI7G8K	2-(4-Cyano-N-(4-methylphenyl)sulfonylanilino)-N-pyridin-3-ylacetamide	Investigative	137656309	C21H18N4O3S	406.5	CC1=CC=C(C=C1)S(=O)(=O)N(CC(=O)NC2=CN=CC=C2)C3=CC=C(C=C3)C#N	IC50 ~ 150000 nM	Poor binder
T16739	Lysine-specific histone demethylase 1	BIFS87	Tert-butyl 4-[[1-[2-(4-fluorophenyl)ethyl]triazol-4-yl]methylsulfanylcarbothioyl]piperazine-1-carboxylate	Investigative	72713324	C21H28FN5O2S2	465.6	CC(C)(C)OC(=O)N1CCN(CC1)C(=S)SCC2=CN(N=N2)CCC3=CC=C(C=C3)F	IC50 ~ 125000 nM	Poor binder
T16739	Lysine-specific histone demethylase 1	BJ79MU	(2S)-2-[[(2S)-2-[[(2S)-5-Amino-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-1-[(2S)-2-[[(2S)-6-amino-2-[[2-[[2-[[(2S,3S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S,3S)-2-[[(2S)-5-amino-2-[[(2S)-6-amino-2-[[(2S,3S)-2-[[(2S)-2-[[(2R)-2-aminopropanoyl]amino]-5-carbamimidamidopentanoyl]amino]-3-hydroxybutanoyl]amino]hexanoyl]amino]-5-oxopentanoyl]amino]-3-hydroxybutanoyl]amino]propanoyl]amino]-5-carbamimidamidopentanoyl]amino]-6-(3,6-dihydro-2H-pyridin-1-yl)hexanoyl]amino]-3-hydroxypropanoyl]amino]-3-hydroxybutanoyl]amino]acetyl]amino]acetyl]amino]hexanoyl]amino]propanoyl]pyrrolidine-2-carbonyl]amino]-5-carbamimidamidopentanoyl]amino]hexanoyl]amino]-5-oxopentanoyl]amino]-4-methylpentanoyl]amino]propanoic acid	Investigative	118728858	C99H178N36O28	2320.7	C[C@@H]([C@@H](C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN1CCC=CC1)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@H](C)O)C(=O)NCC(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)O)NC(=O)[C@H](CCC(=O)N)NC(=O)[C@H](CCCCN)NC(=O)[C@H]([C@H](C)O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](C)N)O	IC50 = 88000 nM	Poor binder
T16739	Lysine-specific histone demethylase 1	BJLD38	4-[2-(4-Methylphenyl)-5-(piperidin-4-ylmethoxy)pyridin-3-yl]benzoic acid	Investigative	127028981	C25H26N2O3	402.5	CC1=CC=C(C=C1)C2=C(C=C(C=N2)OCC3CCNCC3)C4=CC=C(C=C4)C(=O)O	Ki ~ 50000 nM	Poor binder
T16739	Lysine-specific histone demethylase 1	BJOF29	N-[2-(2-Aminocyclopropyl)phenyl]benzamide;hydrochloride	Investigative	118734099	C16H17ClN2O	288.77	C1C(C1N)C2=CC=CC=C2NC(=O)C3=CC=CC=C3.Cl	IC50 = 74650 nM	Poor binder
T16739	Lysine-specific histone demethylase 1	BJPU92	4-(4-Methoxyanilino)-6-phenyl-2-prop-2-ynylsulfanylpyrimidine-5-carbonitrile	Investigative	118713036	C21H16N4OS	372.4	COC1=CC=C(C=C1)NC2=NC(=NC(=C2C#N)C3=CC=CC=C3)SCC#C	IC50 ~ 125000 nM	Poor binder
T16739	Lysine-specific histone demethylase 1	BK5Q1A	Tert-butyl (2S)-2-benzamido-6-(but-2-ynylamino)hexanoate	Investigative	73334475	C21H30N2O3	358.5	CC#CCNCCCC[C@@H](C(=O)OC(C)(C)C)NC(=O)C1=CC=CC=C1	IC50 = 131900 nM	Poor binder
T16739	Lysine-specific histone demethylase 1	BKF4M6	[4-[2-(4-Methylphenyl)-5-(piperidin-4-ylmethoxy)pyridin-3-yl]phenyl]-piperidin-1-ylmethanone	Investigative	127028983	C30H35N3O2	469.6	CC1=CC=C(C=C1)C2=C(C=C(C=N2)OCC3CCNCC3)C4=CC=C(C=C4)C(=O)N5CCCCC5	Ki ~ 50000 nM	Poor binder
T16739	Lysine-specific histone demethylase 1	BKJ8G4	1-[2-(2-Methylanilino)-1,3-thiazol-4-yl]ethanone	Investigative	76329395	C12H12N2OS	232.3	CC1=CC=CC=C1NC2=NC(=CS2)C(=O)C	IC50 ~ 188000 nM	Poor binder
T16739	Lysine-specific histone demethylase 1	BL05PX	3-(4-Ethynylphenyl)-2-(4-methylphenyl)-5-(piperidin-4-ylmethoxy)pyridine	Investigative	127028664	C26H26N2O	382.5	CC1=CC=C(C=C1)C2=C(C=C(C=N2)OCC3CCNCC3)C4=CC=C(C=C4)C#C	Ki ~ 50000 nM	Poor binder
T16739	Lysine-specific histone demethylase 1	BL7H6Q	[1-[(4-Methylphenyl)methyl]triazol-4-yl]methyl piperidine-1-carbodithioate	Investigative	72714190	C17H22N4S2	346.5	CC1=CC=C(C=C1)CN2C=C(N=N2)CSC(=S)N3CCCCC3	IC50 ~ 125000 nM	Poor binder
T16739	Lysine-specific histone demethylase 1	BL9N1W	[1-[(4-Chlorophenyl)methyl]triazol-4-yl]methyl piperazine-1-carbodithioate	Investigative	71652981	C15H18ClN5S2	367.9	C1CN(CCN1)C(=S)SCC2=CN(N=N2)CC3=CC=C(C=C3)Cl	IC50 ~ 125000 nM	Poor binder
T16739	Lysine-specific histone demethylase 1	BLAO26	[1-[(2-Fluorophenyl)methyl]triazol-4-yl]methyl 4-phenylpiperazine-1-carbodithioate	Investigative	72713976	C21H22FN5S2	427.6	C1CN(CCN1C2=CC=CC=C2)C(=S)SCC3=CN(N=N3)CC4=CC=CC=C4F	IC50 ~ 125000 nM	Poor binder
T16739	Lysine-specific histone demethylase 1	BLG8U6	4-(4-Methoxyanilino)-2-prop-2-ynylsulfanyl-6-(3,4,5-trimethoxyphenyl)pyrimidine-5-carbonitrile	Investigative	118733316	C24H22N4O4S	462.5	COC1=CC=C(C=C1)NC2=NC(=NC(=C2C#N)C3=CC(=C(C(=C3)OC)OC)OC)SCC#C	IC50 ~ 125000 nM	Poor binder
T16739	Lysine-specific histone demethylase 1	BLVC31	Tert-butyl 4-[[1-[(7-fluoro-2-oxochromen-4-yl)methyl]triazol-4-yl]methylsulfanylcarbothioyl]piperazine-1-carboxylate	Investigative	73055053	C23H26FN5O4S2	519.6	CC(C)(C)OC(=O)N1CCN(CC1)C(=S)SCC2=CN(N=N2)CC3=CC(=O)OC4=C3C=CC(=C4)F	IC50 = 84200 nM	Poor binder
T16739	Lysine-specific histone demethylase 1	BM02TG	(1R,2S)-2-(3-Phenylphenyl)cyclopropan-1-amine;hydrochloride	Investigative	56683887	C15H16ClN	245.74	C1[C@H]([C@@H]1N)C2=CC=CC(=C2)C3=CC=CC=C3.Cl	Ki ~ 100000 nM	Poor binder
T16739	Lysine-specific histone demethylase 1	BM9W8C	[1-[(2-Fluorophenyl)methyl]triazol-4-yl]methyl piperidine-1-carbodithioate	Investigative	72714188	C16H19FN4S2	350.5	C1CCN(CC1)C(=S)SCC2=CN(N=N2)CC3=CC=CC=C3F	IC50 ~ 125000 nM	Poor binder
T16739	Lysine-specific histone demethylase 1	BMB6X9	(1S,2S)-2-(4-Ethoxyphenyl)-2-fluorocyclopropan-1-amine	Investigative	137641024	C11H14FNO	195.23	CCOC1=CC=C(C=C1)[C@]2(C[C@@H]2N)F	IC50 ~ 50000 nM	Poor binder
T16739	Lysine-specific histone demethylase 1	BN1K7J	N-[4-(4-Chlorophenyl)-1,3-thiazol-2-yl]-4-methoxybenzenesulfonamide	Investigative	76311323	C16H13ClN2O3S2	380.9	COC1=CC=C(C=C1)S(=O)(=O)NC2=NC(=CS2)C3=CC=C(C=C3)Cl	IC50 = 76050 nM	Poor binder
T16739	Lysine-specific histone demethylase 1	BN9H8S	[1-[(4-Chlorophenyl)methyl]triazol-4-yl]methyl morpholine-4-carbodithioate	Investigative	72713114	C15H17ClN4OS2	368.9	C1COCCN1C(=S)SCC2=CN(N=N2)CC3=CC=C(C=C3)Cl	IC50 ~ 125000 nM	Poor binder
T16739	Lysine-specific histone demethylase 1	BNW52O	1-Amino-2-phenylcyclopropanecarboxylic acid, cis-	Investigative	10910111	C10H11NO2	177.2	C1[C@H]([C@@]1(C(=O)O)N)C2=CC=CC=C2	IC50 ~ 100000 nM	Poor binder
T16739	Lysine-specific histone demethylase 1	BO37PG	[4-[2-(4-Methylphenyl)-5-(piperidin-4-ylmethoxy)pyridin-3-yl]phenyl]-morpholin-4-ylmethanone	Investigative	127024901	C29H33N3O3	471.6	CC1=CC=C(C=C1)C2=C(C=C(C=N2)OCC3CCNCC3)C4=CC=C(C=C4)C(=O)N5CCOCC5	Ki ~ 50000 nM	Poor binder
T16739	Lysine-specific histone demethylase 1	BO4QS9	1-{2-[(4-Methoxyphenyl)amino]-1,3-thiazol-4-yl}ethan-1-one	Investigative	76336665	C12H12N2O2S	248.3	CC(=O)C1=CSC(=N1)NC2=CC=C(C=C2)OC	IC50 ~ 188000 nM	Poor binder
T16739	Lysine-specific histone demethylase 1	BO6UJ8	2,3-Diphenyl-5-(piperidin-4-ylmethoxy)pyridine	Investigative	127024955	C23H24N2O	344.4	C1CNCCC1COC2=CC(=C(N=C2)C3=CC=CC=C3)C4=CC=CC=C4	Ki ~ 50000 nM	Poor binder
T16739	Lysine-specific histone demethylase 1	BOI1Q2	1-[Methyl(prop-2-ynyl)amino]-3-naphthalen-2-yloxypropan-2-ol	Investigative	73334588	C17H19NO2	269.34	CN(CC#C)CC(COC1=CC2=CC=CC=C2C=C1)O	IC50 = 51700 nM	Poor binder
T16739	Lysine-specific histone demethylase 1	BOK2U5	Tert-butyl 4-[[1-[(2-hydroxyphenyl)methyl]triazol-4-yl]methylsulfanylcarbothioyl]piperazine-1-carboxylate	Investigative	71616359	C20H27N5O3S2	449.6	CC(C)(C)OC(=O)N1CCN(CC1)C(=S)SCC2=CN(N=N2)CC3=CC=CC=C3O	IC50 = 69200 nM	Poor binder
T16739	Lysine-specific histone demethylase 1	BOK96L	[1-[(4-Fluorophenyl)methyl]triazol-4-yl]methyl 4-methylpiperazine-1-carbodithioate	Investigative	72713760	C16H20FN5S2	365.5	CN1CCN(CC1)C(=S)SCC2=CN(N=N2)CC3=CC=C(C=C3)F	IC50 ~ 125000 nM	Poor binder
T16739	Lysine-specific histone demethylase 1	BOS5B8	4-(4-Chlorophenyl)-6-(4-methoxyanilino)-2-prop-2-ynylsulfanylpyrimidine-5-carbonitrile	Investigative	118733313	C21H15ClN4OS	406.9	COC1=CC=C(C=C1)NC2=NC(=NC(=C2C#N)C3=CC=C(C=C3)Cl)SCC#C	IC50 ~ 125000 nM	Poor binder
T16739	Lysine-specific histone demethylase 1	BPC5I4	Tert-butyl 4-[[1-[2-(2-oxochromen-4-yl)oxyethyl]triazol-4-yl]methylsulfanylcarbothioyl]piperazine-1-carboxylate	Investigative	72713537	C24H29N5O5S2	531.7	CC(C)(C)OC(=O)N1CCN(CC1)C(=S)SCC2=CN(N=N2)CCOC3=CC(=O)OC4=CC=CC=C43	IC50 ~ 125000 nM	Poor binder
T16739	Lysine-specific histone demethylase 1	BPFA52	Tert-butyl 4-[[1-[(3,4-dichlorophenyl)methyl]triazol-4-yl]methylsulfanylcarbothioyl]piperazine-1-carboxylate	Investigative	71616471	C20H25Cl2N5O2S2	502.5	CC(C)(C)OC(=O)N1CCN(CC1)C(=S)SCC2=CN(N=N2)CC3=CC(=C(C=C3)Cl)Cl	IC50 = 88900 nM	Poor binder
T16739	Lysine-specific histone demethylase 1	BPFI27	Tert-butyl 4-[[1-[3-(trifluoromethyl)phenyl]triazol-4-yl]methylsulfanylcarbothioyl]piperazine-1-carboxylate	Investigative	71653426	C20H24F3N5O2S2	487.6	CC(C)(C)OC(=O)N1CCN(CC1)C(=S)SCC2=CN(N=N2)C3=CC=CC(=C3)C(F)(F)F	IC50 ~ 125000 nM	Poor binder
T16739	Lysine-specific histone demethylase 1	BQ5ZR4	Tert-butyl 4-[[1-(1H-benzimidazol-2-ylmethyl)triazol-4-yl]methylsulfanylcarbothioyl]piperazine-1-carboxylate	Investigative	72713540	C21H27N7O2S2	473.6	CC(C)(C)OC(=O)N1CCN(CC1)C(=S)SCC2=CN(N=N2)CC3=NC4=CC=CC=C4N3	IC50 ~ 125000 nM	Poor binder
T16739	Lysine-specific histone demethylase 1	BR4CH7	N-[4-(4-Chlorophenyl)-1,3-thiazol-2-yl]benzamide	Investigative	681700	C16H11ClN2OS	314.8	C1=CC=C(C=C1)C(=O)NC2=NC(=CS2)C3=CC=C(C=C3)Cl	IC50 ~ 188000 nM	Poor binder
T16739	Lysine-specific histone demethylase 1	BR8M0Z	4-(4-Methylanilino)-6-phenyl-2-prop-2-ynylsulfanylpyrimidine-5-carbonitrile	Investigative	118733312	C21H16N4S	356.4	CC1=CC=C(C=C1)NC2=NC(=NC(=C2C#N)C3=CC=CC=C3)SCC#C	IC50 ~ 125000 nM	Poor binder
T16739	Lysine-specific histone demethylase 1	BS16MV	3-Chloro-N-(4-phenyl-1,3-thiazol-2-yl)benzenesulfonamide	Investigative	3132916	C15H11ClN2O2S2	350.8	C1=CC=C(C=C1)C2=CSC(=N2)NS(=O)(=O)C3=CC(=CC=C3)Cl	IC50 = 51600 nM	Poor binder
T16739	Lysine-specific histone demethylase 1	BS8B9Q	[1-[(2-Fluorophenyl)methyl]triazol-4-yl]methyl 4-benzylpiperazine-1-carbodithioate	Investigative	71616589	C22H24FN5S2	441.6	C1CN(CCN1CC2=CC=CC=C2)C(=S)SCC3=CN(N=N3)CC4=CC=CC=C4F	IC50 ~ 125000 nM	Poor binder
T16739	Lysine-specific histone demethylase 1	BSE4H7	Tert-butyl 4-[[1-[[4-(trifluoromethyl)phenyl]methyl]triazol-4-yl]methylsulfanylcarbothioyl]piperazine-1-carboxylate	Investigative	72713117	C21H26F3N5O2S2	501.6	CC(C)(C)OC(=O)N1CCN(CC1)C(=S)SCC2=CN(N=N2)CC3=CC=C(C=C3)C(F)(F)F	IC50 ~ 125000 nM	Poor binder
T16739	Lysine-specific histone demethylase 1	BSJV83	2-Phenyl-5-(piperidin-4-ylmethoxy)pyridine	Investigative	127025530	C17H20N2O	268.35	C1CNCCC1COC2=CN=C(C=C2)C3=CC=CC=C3	Ki ~ 50000 nM	Poor binder
T16739	Lysine-specific histone demethylase 1	BT56XP	2-[5-[(3R)-3-Aminopiperidine-1-carbonyl]-2-(4-cyanophenyl)pyrazol-3-yl]oxyacetamide	Investigative	137639034	C18H20N6O3	368.4	C1C[C@H](CN(C1)C(=O)C2=NN(C(=C2)OCC(=O)N)C3=CC=C(C=C3)C#N)N	IC50 ~ 150000 nM	Poor binder
T16739	Lysine-specific histone demethylase 1	BU46LX	1-Naphthalen-2-yloxy-3-(prop-2-ynylamino)propan-2-ol	Investigative	73334589	C16H17NO2	255.31	C#CCNCC(COC1=CC2=CC=CC=C2C=C1)O	IC50 = 92200 nM	Poor binder
T16739	Lysine-specific histone demethylase 1	BU6A3I	(1-Benzyltriazol-4-yl)methyl morpholine-4-carbodithioate	Investigative	72714193	C15H18N4OS2	334.5	C1COCCN1C(=S)SCC2=CN(N=N2)CC3=CC=CC=C3	IC50 ~ 125000 nM	Poor binder
T16739	Lysine-specific histone demethylase 1	BU7V3N	4-[2-(4-Methylphenyl)-5-phenylmethoxypyridin-3-yl]benzonitrile	Investigative	127025221	C26H20N2O	376.4	CC1=CC=C(C=C1)C2=C(C=C(C=N2)OCC3=CC=CC=C3)C4=CC=C(C=C4)C#N	Ki ~ 50000 nM	Poor binder
T16739	Lysine-specific histone demethylase 1	BUN8R3	Tert-butyl 4-[[1-[(2-oxo-1H-quinolin-4-yl)methyl]triazol-4-yl]methylsulfanylcarbothioyl]piperazine-1-carboxylate	Investigative	72713539	C23H28N6O3S2	500.6	CC(C)(C)OC(=O)N1CCN(CC1)C(=S)SCC2=CN(N=N2)CC3=CC(=O)NC4=CC=CC=C43	IC50 ~ 125000 nM	Poor binder
T16739	Lysine-specific histone demethylase 1	BV1O3Y	1-[4-(4-Chlorophenyl)-1,3-thiazol-2-yl]-3-phenylurea	Investigative	897193	C16H12ClN3OS	329.8	C1=CC=C(C=C1)NC(=O)NC2=NC(=CS2)C3=CC=C(C=C3)Cl	IC50 ~ 188000 nM	Poor binder
T16739	Lysine-specific histone demethylase 1	BVO6K9	trans-2-Phenylcyclopropylamine	Investigative	26070	C9H11N	133.19	C1[C@@H]([C@H]1N)C2=CC=CC=C2	Ki = 168000 nM	Poor binder
T16739	Lysine-specific histone demethylase 1	BW04JO	Tert-butyl 4-[[1-[(4-chlorophenyl)methyl]triazol-4-yl]methylsulfanylcarbothioyl]piperazine-1-carboxylate	Investigative	71616358	C20H26ClN5O2S2	468	CC(C)(C)OC(=O)N1CCN(CC1)C(=S)SCC2=CN(N=N2)CC3=CC=C(C=C3)Cl	IC50 = 56500 nM	Poor binder
T16739	Lysine-specific histone demethylase 1	BW19LA	[1-[(4-Methylphenyl)methyl]triazol-4-yl]methyl 4-benzylpiperazine-1-carbodithioate	Investigative	71616591	C23H27N5S2	437.6	CC1=CC=C(C=C1)CN2C=C(N=N2)CSC(=S)N3CCN(CC3)CC4=CC=CC=C4	IC50 ~ 125000 nM	Poor binder
T16739	Lysine-specific histone demethylase 1	BW25IF	[1-[(4-Chlorophenyl)methyl]triazol-4-yl]methyl piperidine-1-carbodithioate	Investigative	72714192	C16H19ClN4S2	366.9	C1CCN(CC1)C(=S)SCC2=CN(N=N2)CC3=CC=C(C=C3)Cl	IC50 ~ 125000 nM	Poor binder
T16739	Lysine-specific histone demethylase 1	BW37LB	4-Chloro-6-(3-chlorophenyl)-2-prop-2-ynylsulfanylpyrimidine-5-carbonitrile	Investigative	87057441	C14H7Cl2N3S	320.2	C#CCSC1=NC(=C(C(=N1)Cl)C#N)C2=CC(=CC=C2)Cl	IC50 ~ 125000 nM	Poor binder
T16739	Lysine-specific histone demethylase 1	BX4J8M	(1S,2R)-2-Fluoro-2-(4-nitrophenyl)cyclopropan-1-amine	Investigative	137639972	C9H9FN2O2	196.18	C1[C@@H]([C@@]1(C2=CC=C(C=C2)[N+](=O)[O-])F)N	IC50 ~ 50000 nM	Poor binder
T16739	Lysine-specific histone demethylase 1	BX5KM9	2-[[5-Cyano-6-(4-nitrophenyl)-2-prop-2-ynylsulfanylpyrimidin-4-yl]amino]guanidine	Investigative	87056309	C15H12N8O2S	368.4	C#CCSC1=NC(=C(C(=N1)NN=C(N)N)C#N)C2=CC=C(C=C2)[N+](=O)[O-]	IC50 ~ 125000 nM	Poor binder
T16739	Lysine-specific histone demethylase 1	BXU7N8	Tert-butyl (2S)-2-benzamido-6-(prop-2-ynylamino)hexanoate	Investigative	73334474	C20H28N2O3	344.4	CC(C)(C)OC(=O)[C@H](CCCCNCC#C)NC(=O)C1=CC=CC=C1	IC50 = 143600 nM	Poor binder
T16739	Lysine-specific histone demethylase 1	BY3PX8	2-(4-Methoxyphenyl)cyclopropan-1-amine	Investigative	3082143	C10H13NO	163.22	COC1=CC=C(C=C1)C2CC2N	Ki = 188000 nM	Poor binder
T16739	Lysine-specific histone demethylase 1	BYV51W	4-(4-Chlorophenyl)-2-prop-2-ynylsulfanyl-6-[3-(trifluoromethyl)anilino]pyrimidine-5-carbonitrile	Investigative	118733314	C21H12ClF3N4S	444.9	C#CCSC1=NC(=C(C(=N1)NC2=CC=CC(=C2)C(F)(F)F)C#N)C3=CC=C(C=C3)Cl	IC50 ~ 125000 nM	Poor binder
T16739	Lysine-specific histone demethylase 1	BZ81LT	4-(4-Fluoroanilino)-6-phenyl-2-prop-2-ynylsulfanylpyrimidine-5-carbonitrile	Investigative	118733310	C20H13FN4S	360.4	C#CCSC1=NC(=C(C(=N1)NC2=CC=C(C=C2)F)C#N)C3=CC=CC=C3	IC50 = 125000 nM	Poor binder
T16739	Lysine-specific histone demethylase 1	BZ97KN	[[5-Cyano-2-[(3,4-dichlorophenyl)methylsulfanyl]-6-(3,4,5-trimethoxyphenyl)pyrimidin-4-yl]amino]thiourea	Investigative	118733321	C22H20Cl2N6O3S2	551.5	COC1=CC(=CC(=C1OC)OC)C2=C(C(=NC(=N2)SCC3=CC(=C(C=C3)Cl)Cl)NNC(=S)N)C#N	IC50 = 98174.79 nM	Poor binder
T16739	Lysine-specific histone demethylase 1	BZCX31	1-[2-(2-Chloroanilino)thiazole-4-yl]ethanone	Investigative	2744808	C11H9ClN2OS	252.72	CC(=O)C1=CSC(=N1)NC2=CC=CC=C2Cl	IC50 ~ 188000 nM	Poor binder