TTD_Target_ID	Target_Name	TTD_Drug_ID	Drug_Name	Drug_Highest_Status	Drug_PubchemID	Molecular_Formula	Molecular_Weight	Canonical_SMILES	Activity	Binder_Type
T16902	Histone acetyltransferase KAT2B	D09CKU	PMID26394986-Compound-44	Patented	65064	C22H18O11	458.4	C1[C@H]([C@H](OC2=CC(=CC(=C21)O)O)C3=CC(=C(C(=C3)O)O)O)OC(=O)C4=CC(=C(C(=C4)O)O)O	IC50 = 60000 nM	Poor binder
T16902	Histone acetyltransferase KAT2B	B0YH5M	3-(4-Methoxy-2-nitrophenoxy)propan-1-amine;hydrochloride	Investigative	11380016	C10H15ClN2O4	262.69	COC1=CC(=C(C=C1)OCCCN)[N+](=O)[O-].Cl	IC50 = 102700 nM	Poor binder
T16902	Histone acetyltransferase KAT2B	B2ISO1	4-Cyano-N-(1,3-diethyl-2-oxoquinolin-6-yl)benzenesulfonamide	Investigative	137636309	C20H19N3O3S	381.4	CCC1=CC2=C(C=CC(=C2)NS(=O)(=O)C3=CC=C(C=C3)C#N)N(C1=O)CC	IC50 ~ 100000 nM	Poor binder
T16902	Histone acetyltransferase KAT2B	B3DM8C	6-[(5Z)-5-[1-[(4-Nitrophenyl)methyl]-2-oxoindol-3-ylidene]-4-oxo-2-sulfanylidene-1,3-thiazolidin-3-yl]hexanoic acid	Investigative	90667752	C24H21N3O6S2	511.6	C1=CC=C2C(=C1)/C(=C/3\\C(=O)N(C(=S)S3)CCCCCC(=O)O)/C(=O)N2CC4=CC=C(C=C4)[N+](=O)[O-]	IC50 = 78200 nM	Poor binder
T16902	Histone acetyltransferase KAT2B	B4B8ZG	5-Acetoxymethyl-2-phenylisothiazol-3(2H)-one	Investigative	44564517	C12H11NO3S	249.29	CC(=O)OCC1=CC(=O)N(S1)C2=CC=CC=C2	IC50 = 162000 nM	Poor binder
T16902	Histone acetyltransferase KAT2B	B4EWH6	3-(2-Nitrophenoxy)propan-1-amine;hydrochloride	Investigative	11379279	C9H13ClN2O3	232.66	C1=CC=C(C(=C1)[N+](=O)[O-])OCCCN.Cl	IC50 = 125600 nM	Poor binder
T16902	Histone acetyltransferase KAT2B	B5OH8D	4-Methoxymethyl-2-phenyl-isothiazol-3(2H)-one	Investigative	44564013	C11H11NO2S	221.28	COCC1=CSN(C1=O)C2=CC=CC=C2	IC50 = 102000 nM	Poor binder
T16902	Histone acetyltransferase KAT2B	B5XBJ1	2-Benzyl-6-nitro-1,2-benzothiazol-3-one	Investigative	703058	C14H10N2O3S	286.31	C1=CC=C(C=C1)CN2C(=O)C3=C(S2)C=C(C=C3)[N+](=O)[O-]	IC50 = 51300 nM	Poor binder
T16902	Histone acetyltransferase KAT2B	B7J6WO	6-{(5Z)-5-[1-(4-Methylbenzyl)-2-oxo-1,2-dihydro-3H-indol-3-ylidene]-4-oxo-2-thioxo-1,3-thiazolidin-3-yl}hexanoic acid	Investigative	1561807	C25H24N2O4S2	480.6	CC1=CC=C(C=C1)CN2C3=CC=CC=C3/C(=C/4\\C(=O)N(C(=S)S4)CCCCCC(=O)O)/C2=O	IC50 = 67200 nM	Poor binder
T16902	Histone acetyltransferase KAT2B	BCG1H6	1,2-Benzisothiazole-2(3H)-butanoic acid, 3-oxo-	Investigative	462934	C11H11NO3S	237.28	C1=CC=C2C(=C1)C(=O)N(S2)CCCC(=O)O	IC50 = 67000 nM	Poor binder
T16902	Histone acetyltransferase KAT2B	BCXJ90	Chembl4170165	Investigative	145954899	C11H11NO2	189.21	COC1=C(C2=CC=CC=C2C(=C1)O)N	IC50 = 200000 nM	Poor binder
T16902	Histone acetyltransferase KAT2B	BD5U7E	3-(4-Methyl-2-nitrophenoxy)propan-1-amine;hydrochloride	Investigative	11345613	C10H15ClN2O3	246.69	CC1=CC(=C(C=C1)OCCCN)[N+](=O)[O-].Cl	IC50 = 180000 nM	Poor binder
T16902	Histone acetyltransferase KAT2B	BD7K6U	1-Methyl-2-quinolone	Investigative	11820	C10H9NO	159.18	CN1C(=O)C=CC2=CC=CC=C21	IC50 = 70000 nM	Poor binder
T16902	Histone acetyltransferase KAT2B	BDK35M	N'-(2-Methyl-5-nitrophenyl)propane-1,3-diamine;hydrochloride	Investigative	11390927	C10H16ClN3O2	245.7	CC1=C(C=C(C=C1)[N+](=O)[O-])NCCCN.Cl	IC50 = 77800 nM	Poor binder
T16902	Histone acetyltransferase KAT2B	BE0S7D	2-[(3,4-Difluorophenyl)methyl]-[1,2]thiazolo[5,4-b]pyridin-3-one	Investigative	56683381	C13H8F2N2OS	278.28	C1=CC2=C(N=C1)SN(C2=O)CC3=CC(=C(C=C3)F)F	IC50 = 101000 nM	Poor binder
T16902	Histone acetyltransferase KAT2B	BFK06R	8-[(5Z)-5-[1-[(4-Methylphenyl)methyl]-2-oxoindol-3-ylidene]-4-oxo-2-sulfanylidene-1,3-thiazolidin-3-yl]octanoic acid	Investigative	90667754	C27H28N2O4S2	508.7	CC1=CC=C(C=C1)CN2C3=CC=CC=C3/C(=C/4\\C(=O)N(C(=S)S4)CCCCCCCC(=O)O)/C2=O	IC50 = 63700 nM	Poor binder
T16902	Histone acetyltransferase KAT2B	BKN94D	[[(3S)-4-[[3-[2-[[1-[(5S)-5-[[2-[[2-[[(2S,3R)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-Acetamidopropanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]-6-aminohexanoyl]amino]-3-hydroxypropanoyl]amino]-3-hydroxybutanoyl]amino]acetyl]amino]acetyl]amino]-6-[[(2S)-1-[(2S)-2-[[(2S)-5-(diaminomethylideneamino)-1-[[(2S)-1,6-diamino-1-oxohexan-2-yl]amino]-1-oxopentan-2-yl]carbamoyl]pyrrolidin-1-yl]-1-oxopropan-2-yl]amino]-6-oxohexyl]triazol-4-yl]methylsulfanyl]ethylamino]-3-oxopropyl]amino]-3-hydroxy-2,2-dimethyl-4-oxobutoxy]-hydroxyphosphoryl] [(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-4-hydroxy-3-phosphonooxyoxolan-2-yl]methyl hydrogen phosphate	Investigative	76320952	C78H136N31O31P3S	2129.1	C[C@H]([C@@H](C(=O)NCC(=O)NCC(=O)N[C@@H](CCCCN1C=C(N=N1)CSCCNC(=O)CCNC(=O)[C@H](C(C)(C)COP(=O)(O)OP(=O)(O)OC[C@@H]2[C@H]([C@H]([C@@H](O2)N3C=NC4=C(N=CN=C43)N)O)OP(=O)(O)O)O)C(=O)N[C@@H](C)C(=O)N5CCC[C@H]5C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCCN)C(=O)N)NC(=O)[C@H](CO)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](C)NC(=O)C)O	IC50 = 117000 nM	Poor binder
T16902	Histone acetyltransferase KAT2B	BL9I7P	Chembl4170179	Investigative	145955588	C20H27NO2	313.4	CCCCCCCCCC(=O)NC1=CC=C(C2=CC=CC=C21)O	IC50 = 160000 nM	Poor binder
T16902	Histone acetyltransferase KAT2B	BNHW23	Ac-Lys(CoA)-NH2	Investigative	44571034	C31H53N10O19P3S	994.8	CC(=O)N[C@@H](CCCCNC(=O)CSCCNC(=O)CCNC(=O)[C@@H](C(C)(C)COP(=O)(O)OP(=O)(O)OC[C@@H]1[C@H]([C@H]([C@@H](O1)N2C=NC3=C(N=CN=C32)N)O)OP(=O)(O)O)O)C(=O)N	IC50 = 108300 nM	Poor binder
T16902	Histone acetyltransferase KAT2B	BO75JV	6-{(5Z)-5-[1-(4-Fluorobenzyl)-2-oxo-1,2-dihydro-3H-indol-3-ylidene]-4-oxo-2-thioxo-1,3-thiazolidin-3-yl}hexanoic acid	Investigative	1600566	C24H21FN2O4S2	484.6	C1=CC=C2C(=C1)/C(=C/3\\C(=O)N(C(=S)S3)CCCCCC(=O)O)/C(=O)N2CC4=CC=C(C=C4)F	IC50 = 97700 nM	Poor binder
T16902	Histone acetyltransferase KAT2B	BP68NK	2-[(4-Fluorophenyl)methyl]-[1,2]thiazolo[5,4-b]pyridin-3-one	Investigative	56662996	C13H9FN2OS	260.29	C1=CC2=C(N=C1)SN(C2=O)CC3=CC=C(C=C3)F	IC50 = 86300 nM	Poor binder
T16902	Histone acetyltransferase KAT2B	BR8IH7	2-[4-[2-[3-(3,4-Dimethoxyphenyl)-5-thiophen-2-yl-3,4-dihydropyrazol-2-yl]-1,3-thiazol-4-yl]phenyl]isoindole-1,3-dione	Investigative	2854538	C32H24N4O4S2	592.7	COC1=C(C=C(C=C1)C2CC(=NN2C3=NC(=CS3)C4=CC=C(C=C4)N5C(=O)C6=CC=CC=C6C5=O)C7=CC=CS7)OC	IC50 ~ 100000 nM	Poor binder
T16902	Histone acetyltransferase KAT2B	BU0I8J	Cambridge id 5139258	Investigative	2829592	C10H16ClN3O2	245.7	C1=CC=C(C(=C1)NCCCCN)[N+](=O)[O-].Cl	IC50 = 145900 nM	Poor binder
T16902	Histone acetyltransferase KAT2B	BV0F5R	5-Azidomethyl-2-phenylisothiazol-3(2H)-one	Investigative	44564010	C10H8N4OS	232.26	C1=CC=C(C=C1)N2C(=O)C=C(S2)CN=[N+]=[N-]	IC50 = 58000 nM	Poor binder
T16902	Histone acetyltransferase KAT2B	BVCJ21	5-Hydroxymethyl-2-phenylisothiazol-3(2H)-one	Investigative	44564515	C10H9NO2S	207.25	C1=CC=C(C=C1)N2C(=O)C=C(S2)CO	IC50 = 109000 nM	Poor binder
T16902	Histone acetyltransferase KAT2B	BWX39D	2-[[4-(Trifluoromethyl)phenyl]methyl]isothiazolo[5,4-b]pyridin-3(2H)-one	Investigative	53257845	C14H9F3N2OS	310.3	C1=CC2=C(N=C1)SN(C2=O)CC3=CC=C(C=C3)C(F)(F)F	IC50 = 130000 nM	Poor binder
T16902	Histone acetyltransferase KAT2B	D0P0IE	Plumbagin	Investigative	10205	C11H8O3	188.18	CC1=CC(=O)C2=C(C1=O)C=CC=C2O	IC50 = 50000 nM	Poor binder