TTD_Target_ID	Target_Name	TTD_Drug_ID	Drug_Name	Drug_Highest_Status	Drug_PubchemID	Molecular_Formula	Molecular_Weight	Canonical_SMILES	Activity	Binder_Type
T18904	Lysine-specific demethylase 4A	D00VLQ	Hydroxyqunoline analog 1	Patented	459617	C10H7NO3	189.17	C1=CC2=C(C=CC(=C2N=C1)O)C(=O)O	IC50 = 86500 nM	Poor binder
T18904	Lysine-specific demethylase 4A	B0E2WV	3-(10-Methylundecanoylhydroxyamino)propionic acid methyl ester	Investigative	73333510	C16H31NO4	301.42	CC(C)CCCCCCCCC(=O)N(CCC(=O)OC)O	IC50 ~ 120000 nM	Poor binder
T18904	Lysine-specific demethylase 4A	B17QWK	Chembl4208277	Investigative	145977225	C73H116N26O15S	1629.9	CC[C@H](C)[C@H]1C(=O)N[C@H](C(=O)N[C@H](C(=O)N([C@@H](CSCC(=O)N[C@H](C(=O)N2CCC[C@H]2C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](C(=O)N1)C)CO)CCCNC(=N)N)CCCNC(=N)N)[C@@H](C)CC)CCCNC(=N)N)CC3=CC=C(C=C3)O)C(=O)N)C)CC4=CNC5=CC=CC=C54)CCCNC(=N)N	EC50 ~ 50000 nM	Poor binder
T18904	Lysine-specific demethylase 4A	B1BOC8	Chembl4206582	Investigative	145976400	C72H114N26O15S	1615.9	CC[C@H](C)[C@H]1C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CSCC(=O)N[C@H](C(=O)N2CCC[C@H]2C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](C(=O)N1)C)CO)CCCNC(=N)N)CCCNC(=N)N)[C@@H](C)CC)CCCNC(=N)N)CC3=CC=C(C=C3)O)C(=O)N)CC4=CNC5=CC=CC=C54)CCCNC(=N)N	EC50 ~ 50000 nM	Poor binder
T18904	Lysine-specific demethylase 4A	B1I6GR	8-Hydroxy-2-(1-methylpiperidine-4-carbonyl)quinoline-5-carboxylic acid	Investigative	122196478	C17H18N2O4	314.34	CN1CCC(CC1)C(=O)C2=NC3=C(C=CC(=C3C=C2)C(=O)O)O	IC50 = 50000 nM	Poor binder
T18904	Lysine-specific demethylase 4A	B1S4EU	8-[(4-Phenylpiperazin-1-yl)methyl]-3H-pyrido[3,4-d]pyrimidin-4-one	Investigative	137175087	C18H19N5O	321.4	C1CN(CCN1CC2=NC=CC3=C2N=CNC3=O)C4=CC=CC=C4	IC50 ~ 100000 nM	Poor binder
T18904	Lysine-specific demethylase 4A	B1U0DO	Di-N-desethylamiodarone	Investigative	125134	C21H21I2NO3	589.2	CCCCC1=C(C2=CC=CC=C2O1)C(=O)C3=CC(=C(C(=C3)I)OCCN)I	IC50 = 72000 nM	Poor binder
T18904	Lysine-specific demethylase 4A	B1VI5N	Chembl4218774	Investigative	145968018	C78H116N24O15S	1662	CC[C@H](C)[C@H]1C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)NCC(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N([C@@H](CSCC(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N1)CCCNC(=N)N)[C@@H](C)CC)CC2=CC=C(C=C2)O)C(=O)N)C)CC3=CNC4=CC=CC=C43)CC(C)C)CC5=CNC6=CC=CC=C65)CO)CCCNC(=N)N)CCCNC(=N)N	EC50 ~ 50000 nM	Poor binder
T18904	Lysine-specific demethylase 4A	B26IYR	8-Hydroxy-2-[(3-methoxyphenyl)carbamoyl]quinoline-5-carboxylic acid	Investigative	122196462	C18H14N2O5	338.3	COC1=CC=CC(=C1)NC(=O)C2=NC3=C(C=CC(=C3C=C2)C(=O)O)O	IC50 ~ 100000 nM	Poor binder
T18904	Lysine-specific demethylase 4A	B2FGQ6	Chembl4205285	Investigative	145978535	C78H116N24O15S	1662	CC[C@H](C)[C@H]1C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CSCC(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N1)CCCNC(=N)N)[C@@H](C)CC)CC2=CC=C(C=C2)O)C(=O)N)CC3=CNC4=CC=CC=C43)CC(C)C)CC5=CNC6=CC=CC=C65)C)CO)CCCNC(=N)N)CCCNC(=N)N	EC50 ~ 50000 nM	Poor binder
T18904	Lysine-specific demethylase 4A	B2HCV4	Chembl4209558	Investigative	145966600	C71H112N26O15S	1601.9	CC[C@H](C)[C@H]1C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CSCC(=O)N[C@H](C(=O)N2CCC[C@H]2C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)NCC(=O)N1)CO)CCCNC(=N)N)CCCNC(=N)N)[C@@H](C)CC)CCCNC(=N)N)CC3=CC=C(C=C3)O)C(=O)N)CC4=CNC5=CC=CC=C54)CCCNC(=N)N	EC50 ~ 50000 nM	Poor binder
T18904	Lysine-specific demethylase 4A	B2LZC0	2-(Cyclohexylcarbamoyl)-8-hydroxyquinoline-5-carboxylic acid	Investigative	122196460	C17H18N2O4	314.34	C1CCC(CC1)NC(=O)C2=NC3=C(C=CC(=C3C=C2)C(=O)O)O	IC50 ~ 100000 nM	Poor binder
T18904	Lysine-specific demethylase 4A	B3JMD0	8-(Piperidin-1-ylmethyl)-3H-pyrido[3,4-d]pyrimidin-4-one	Investigative	137175225	C13H16N4O	244.29	C1CCN(CC1)CC2=NC=CC3=C2N=CNC3=O	IC50 ~ 100000 nM	Poor binder
T18904	Lysine-specific demethylase 4A	B3WD6Y	Chembl4212908	Investigative	145965089	C16H23NO	245.36	CN(C)C[C@@H]1[C@@H](C2(CCC1C2)C3=CC=CC=C3)O	EC50 = 105000 nM	Poor binder
T18904	Lysine-specific demethylase 4A	B4LC1H	8-Hydroxy-2-(phenylcarbamoyl)quinoline-5-carboxylic acid	Investigative	122196457	C17H12N2O4	308.29	C1=CC=C(C=C1)NC(=O)C2=NC3=C(C=CC(=C3C=C2)C(=O)O)O	IC50 ~ 100000 nM	Poor binder
T18904	Lysine-specific demethylase 4A	B5MF0W	2-[1-(2-Phenylethyl)triazol-4-yl]pyridine-4-carboxylic acid	Investigative	122191459	C16H14N4O2	294.31	C1=CC=C(C=C1)CCN2C=C(N=N2)C3=NC=CC(=C3)C(=O)O	IC50 = 63095.73 nM	Poor binder
T18904	Lysine-specific demethylase 4A	B5UR7L	3-(N-Hydroxy-7-methyloctanamido)propanoic acid	Investigative	46901246	C12H23NO4	245.32	CC(C)CCCCCC(=O)N(CCC(=O)O)O	IC50 = 120000 nM	Poor binder
T18904	Lysine-specific demethylase 4A	B5WC8Q	Potassium;2-(1-benzyltriazol-4-yl)pyridine-4-carboxylate	Investigative	122191457	C15H11KN4O2	318.37	C1=CC=C(C=C1)CN2C=C(N=N2)C3=NC=CC(=C3)C(=O)[O-].[K+]	IC50 = 79432.82 nM	Poor binder
T18904	Lysine-specific demethylase 4A	B6C2FB	8-Hydroxy-2-(naphthalen-1-ylcarbamoyl)quinoline-5-carboxylic acid	Investigative	122196458	C21H14N2O4	358.3	C1=CC=C2C(=C1)C=CC=C2NC(=O)C3=NC4=C(C=CC(=C4C=C3)C(=O)O)O	IC50 ~ 100000 nM	Poor binder
T18904	Lysine-specific demethylase 4A	B6FWZ9	2-[1-[1-(3-Phenylpropanoyl)piperidin-4-yl]triazol-4-yl]pyridine-4-carboxylic acid	Investigative	122191466	C22H23N5O3	405.4	C1CN(CCC1N2C=C(N=N2)C3=NC=CC(=C3)C(=O)O)C(=O)CCC4=CC=CC=C4	IC50 = 79432.82 nM	Poor binder
T18904	Lysine-specific demethylase 4A	B6TEQ4	2-[1-(1-Benzoylpiperidin-3-yl)triazol-4-yl]pyridine-4-carboxylic acid	Investigative	122191480	C20H19N5O3	377.4	C1CC(CN(C1)C(=O)C2=CC=CC=C2)N3C=C(N=N3)C4=NC=CC(=C4)C(=O)O	IC50 = 63095.73 nM	Poor binder
T18904	Lysine-specific demethylase 4A	B6UZ0B	3-(9-Cycloheptylnonanoylhydroxyamino)propionic acid	Investigative	71735842	C19H35NO4	341.5	C1CCCC(CC1)CCCCCCCCC(=O)N(CCC(=O)O)O	IC50 = 99000 nM	Poor binder
T18904	Lysine-specific demethylase 4A	B70ITZ	2-[1-(1-Ethoxycarbonylpiperidin-4-yl)triazol-4-yl]pyridine-4-carboxylic acid	Investigative	122191461	C16H19N5O4	345.35	CCOC(=O)N1CCC(CC1)N2C=C(N=N2)C3=NC=CC(=C3)C(=O)O	IC50 ~ 100000 nM	Poor binder
T18904	Lysine-specific demethylase 4A	B74FJW	2-[1-(1-Benzoylazetidin-3-yl)triazol-4-yl]pyridine-4-carboxylic acid	Investigative	122191470	C18H15N5O3	349.3	C1C(CN1C(=O)C2=CC=CC=C2)N3C=C(N=N3)C4=NC=CC(=C4)C(=O)O	IC50 ~ 100000 nM	Poor binder
T18904	Lysine-specific demethylase 4A	B90QWE	Chembl4203936	Investigative	145977546	C95H119N25O21S	1979.2	C[C@H]([C@H]1C(=O)N[C@H](C(=O)N[C@H](C(=O)NCC(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CSCC(=O)N[C@@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N1)CC(=O)N)CC2=CC=C(C=C2)O)C(C)C)CC3=CC=C(C=C3)O)C(=O)N)CC4=CNC5=CC=CC=C54)CC6=CC=C(C=C6)O)CC7=CNC8=CC=CC=C87)CCCNC(=N)N)CC9=CNC1=CC=CC=C19)CO)CCCNC(=N)N)O	EC50 ~ 100000 nM	Poor binder
T18904	Lysine-specific demethylase 4A	B9CEN8	Chembl4209038	Investigative	145967298	C78H116N24O15S	1662	CC[C@H](C)[C@H]1C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)NCC(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CSCC(=O)N[C@H](C(=O)N([C@H](C(=O)N[C@H](C(=O)N1)CCCNC(=N)N)[C@@H](C)CC)C)CC2=CC=C(C=C2)O)C(=O)N)CC3=CNC4=CC=CC=C43)CC(C)C)CC5=CNC6=CC=CC=C65)CO)CCCNC(=N)N)CCCNC(=N)N	EC50 ~ 50000 nM	Poor binder
T18904	Lysine-specific demethylase 4A	B9ES5B	3-(10-Methylundecanoylhydroxyamino)propionic acid	Investigative	73352277	C15H29NO4	287.39	CC(C)CCCCCCCCC(=O)N(CCC(=O)O)O	IC50 = 92000 nM	Poor binder
T18904	Lysine-specific demethylase 4A	B9PTG1	Chembl4215000	Investigative	145972063	C80H120N24O15S	1690	CC[C@H](C)[C@H]1C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N([C@@H](CSCC(=O)N[C@H](C(=O)N([C@H](C(=O)N[C@H](C(=O)N1)CCCNC(=N)N)[C@@H](C)CC)C)CC2=CC=C(C=C2)O)C(=O)N)C)CC3=CNC4=CC=CC=C43)CC(C)C)CC5=CNC6=CC=CC=C65)C)CO)CCCNC(=N)N)CCCNC(=N)N	EC50 ~ 50000 nM	Poor binder
T18904	Lysine-specific demethylase 4A	B9UVL8	2-[(2-Furylmethyl)amino]nicotinic acid	Investigative	28330466	C11H10N2O3	218.21	C1=CC(=C(N=C1)NCC2=CC=CO2)C(=O)O	IC50 ~ 100000 nM	Poor binder
T18904	Lysine-specific demethylase 4A	BA6EQ7	Chembl4208111	Investigative	145978411	C72H114N26O15S	1615.9	CC[C@H](C)[C@H]1C(=O)N[C@H](C(=O)N[C@H](C(=O)N([C@@H](CSCC(=O)N[C@H](C(=O)N2CCC[C@H]2C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)NCC(=O)N1)CO)CCCNC(=N)N)CCCNC(=N)N)[C@@H](C)CC)CCCNC(=N)N)CC3=CC=C(C=C3)O)C(=O)N)C)CC4=CNC5=CC=CC=C54)CCCNC(=N)N	EC50 ~ 50000 nM	Poor binder
T18904	Lysine-specific demethylase 4A	BAB3Y9	8-Hydroxy-2-[(4-methylphenyl)carbamoyl]quinoline-5-carboxylic acid	Investigative	122196465	C18H14N2O4	322.3	CC1=CC=C(C=C1)NC(=O)C2=NC3=C(C=CC(=C3C=C2)C(=O)O)O	IC50 ~ 100000 nM	Poor binder
T18904	Lysine-specific demethylase 4A	BAZ50S	2-[(4-Fluorophenyl)carbamoyl]-8-hydroxyquinoline-5-carboxylic acid	Investigative	122196466	C17H11FN2O4	326.28	C1=CC(=CC=C1NC(=O)C2=NC3=C(C=CC(=C3C=C2)C(=O)O)O)F	IC50 ~ 100000 nM	Poor binder
T18904	Lysine-specific demethylase 4A	BB4I2V	3-(9-Phenylnonanoylhydroxyamino)propionic acid	Investigative	71735840	C18H27NO4	321.4	C1=CC=C(C=C1)CCCCCCCCC(=O)N(CCC(=O)O)O	IC50 = 65000 nM	Poor binder
T18904	Lysine-specific demethylase 4A	BCG7Z1	3-(9-Cyclohexylnonanoylhydroxyamino)propionic acid	Investigative	71735687	C18H33NO4	327.5	C1CCC(CC1)CCCCCCCCC(=O)N(CCC(=O)O)O	IC50 ~ 120000 nM	Poor binder
T18904	Lysine-specific demethylase 4A	BDI7W1	2-(1-Benzylpyrazol-4-yl)oxy-3H-pyrido[2,3-d]pyrimidin-4-one	Investigative	136644692	C17H13N5O2	319.32	C1=CC=C(C=C1)CN2C=C(C=N2)OC3=NC4=C(C=CC=N4)C(=O)N3	IC50 ~ 100000 nM	Poor binder
T18904	Lysine-specific demethylase 4A	BIB8Z2	8-Hydroxy-2-[[4-(trifluoromethoxy)phenyl]carbamoyl]quinoline-5-carboxylic acid	Investigative	122196469	C18H11F3N2O5	392.3	C1=CC(=CC=C1NC(=O)C2=NC3=C(C=CC(=C3C=C2)C(=O)O)O)OC(F)(F)F	IC50 ~ 100000 nM	Poor binder
T18904	Lysine-specific demethylase 4A	BL5A6U	8-Hydroxy-2-(3-morpholin-4-ylpropylcarbamoyl)quinoline-5-carboxylic acid	Investigative	122196475	C18H21N3O5	359.4	C1COCCN1CCCNC(=O)C2=NC3=C(C=CC(=C3C=C2)C(=O)O)O	IC50 = 82000 nM	Poor binder
T18904	Lysine-specific demethylase 4A	BO0H6J	3-(Decanoylhydroxyamino)propionic acid	Investigative	71735839	C13H25NO4	259.339	CCCCCCCCCC(=O)N(CCC(=O)O)O	IC50 = 100000 nM	Poor binder
T18904	Lysine-specific demethylase 4A	BO71RJ	2-[[4-(Dimethylamino)phenyl]carbamoyl]-8-hydroxyquinoline-5-carboxylic acid	Investigative	122196468	C19H17N3O4	351.4	CN(C)C1=CC=C(C=C1)NC(=O)C2=NC3=C(C=CC(=C3C=C2)C(=O)O)O	IC50 ~ 100000 nM	Poor binder
T18904	Lysine-specific demethylase 4A	BOT75I	8-Hydroxy-2-[(4-methoxyphenyl)carbamoyl]quinoline-5-carboxylic acid	Investigative	122196461	C18H14N2O5	338.3	COC1=CC=C(C=C1)NC(=O)C2=NC3=C(C=CC(=C3C=C2)C(=O)O)O	IC50 ~ 100000 nM	Poor binder
T18904	Lysine-specific demethylase 4A	BQ83LB	3-(9-Cyclopentylnonanoylhydroxyamino)propionic acid	Investigative	71735841	C17H31NO4	313.4	C1CCC(C1)CCCCCCCCC(=O)N(CCC(=O)O)O	IC50 ~ 120000 nM	Poor binder
T18904	Lysine-specific demethylase 4A	BSU1P3	2-(Benzylcarbamoyl)-8-hydroxyquinoline-5-carboxylic acid	Investigative	122196470	C18H14N2O4	322.3	C1=CC=C(C=C1)CNC(=O)C2=NC3=C(C=CC(=C3C=C2)C(=O)O)O	IC50 ~ 100000 nM	Poor binder
T18904	Lysine-specific demethylase 4A	BSY1E4	N-(9-Cyclopropyl-1-oxononyl)-N-hydroxy-beta-alanine	Investigative	71735843	C15H27NO4	285.38	C1CC1CCCCCCCCC(=O)N(CCC(=O)O)O	IC50 ~ 120000 nM	Poor binder
T18904	Lysine-specific demethylase 4A	BSY64Q	Chembl4204694	Investigative	145977327	C88H124N24O20S	1870.1	CC[C@H](C)[C@H]1C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CSCC(=O)N[C@@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)NCC(=O)N1)CO)CCCNC(=N)N)CCCNC(=N)N)CC2=CC=CC=C2)CCCNC(=N)N)[C@H](C)O)CC3=CC=C(C=C3)O)C(=O)N)CC4=CC=C(C=C4)O)CC5=CC=C(C=C5)O)CC6=CC=CC=C6)C(C)C	EC50 ~ 50000 nM	Poor binder
T18904	Lysine-specific demethylase 4A	BT3E7X	2-[(3-Methylthiophen-2-yl)methylamino]pyridine-3-carboxylic acid	Investigative	112726150	C12H12N2O2S	248.3	CC1=C(SC=C1)CNC2=C(C=CC=N2)C(=O)O	IC50 ~ 100000 nM	Poor binder
T18904	Lysine-specific demethylase 4A	BT3UN2	Chembl4218675	Investigative	145967792	C77H114N24O15S	1647.9	CC[C@H](C)[C@H]1C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)NCC(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CSCC(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N1)CCCNC(=N)N)[C@@H](C)CC)CC2=CC=C(C=C2)O)C(=O)N)CC3=CNC4=CC=CC=C43)CC(C)C)CC5=CNC6=CC=CC=C65)CO)CCCNC(=N)N)CCCNC(=N)N	EC50 ~ 50000 nM	Poor binder
T18904	Lysine-specific demethylase 4A	BTWI25	8-[(4-Pyridin-2-ylpiperazin-1-yl)methyl]-3H-pyrido[3,4-d]pyrimidin-4-one	Investigative	137175088	C17H18N6O	322.4	C1CN(CCN1CC2=NC=CC3=C2N=CNC3=O)C4=CC=CC=N4	IC50 = 58600 nM	Poor binder
T18904	Lysine-specific demethylase 4A	BVUL43	2-[1-(1-Benzoylpiperidin-4-yl)triazol-4-yl]pyridine-4-carboxylic acid	Investigative	122191464	C20H19N5O3	377.4	C1CN(CCC1N2C=C(N=N2)C3=NC=CC(=C3)C(=O)O)C(=O)C4=CC=CC=C4	IC50 = 50118.72 nM	Poor binder
T18904	Lysine-specific demethylase 4A	BWO0F5	2-[(2-Fluorophenyl)carbamoyl]-8-hydroxyquinoline-5-carboxylic acid	Investigative	122196467	C17H11FN2O4	326.28	C1=CC=C(C(=C1)NC(=O)C2=NC3=C(C=CC(=C3C=C2)C(=O)O)O)F	IC50 ~ 100000 nM	Poor binder
T18904	Lysine-specific demethylase 4A	BWZ08P	8-Hydroxy-2-[(3-methylphenyl)carbamoyl]quinoline-5-carboxylic acid	Investigative	122196463	C18H14N2O4	322.3	CC1=CC(=CC=C1)NC(=O)C2=NC3=C(C=CC(=C3C=C2)C(=O)O)O	IC50 ~ 100000 nM	Poor binder
T18904	Lysine-specific demethylase 4A	BX63EH	2-[1-(2-Phenoxyethyl)triazol-4-yl]pyridine-4-carboxylic acid	Investigative	122191460	C16H14N4O3	310.31	C1=CC=C(C=C1)OCCN2C=C(N=N2)C3=NC=CC(=C3)C(=O)O	IC50 ~ 100000 nM	Poor binder
T18904	Lysine-specific demethylase 4A	BX9R8E	2-(2-Azanyl-1,3-Thiazol-4-Yl)pyridine-4-Carboxamide	Investigative	112499933	C9H8N4OS	220.25	C1=CN=C(C=C1C(=O)N)C2=CSC(=N2)N	IC50 = 104200 nM	Poor binder
T18904	Lysine-specific demethylase 4A	BZ0HR9	8-Hydroxy-2-[(2-methylphenyl)carbamoyl]quinoline-5-carboxylic acid	Investigative	122196464	C18H14N2O4	322.3	CC1=CC=CC=C1NC(=O)C2=NC3=C(C=CC(=C3C=C2)C(=O)O)O	IC50 ~ 100000 nM	Poor binder