TTD_Target_ID	Target_Name	TTD_Drug_ID	Drug_Name	Drug_Highest_Status	Drug_PubchemID	Molecular_Formula	Molecular_Weight	Canonical_SMILES	Activity	Binder_Type
T23276	Extracellular signal-regulated kinase 1	D04FHB	R547	Discontinued in Phase 1	6918852	C18H21F2N5O4S	441.5	COC1=C(C(=C(C=C1)F)F)C(=O)C2=CN=C(N=C2N)NC3CCN(CC3)S(=O)(=O)C	Ki ~ 50000 nM	Poor binder
T23276	Extracellular signal-regulated kinase 1	B27PBJ	(4S,6E)-18-Hydroxy-16-methoxy-4-methyl-3-oxabicyclo[12.4.0]octadeca-1(14),6,15,17-tetraene-2,8-dione	Investigative	49842778	C19H24O5	332.4	C[C@H]1C/C=C/C(=O)CCCCCC2=C(C(=CC(=C2)OC)O)C(=O)O1	IC50 ~ 100000 nM	Poor binder
T23276	Extracellular signal-regulated kinase 1	B3UI9B	1-(2-Hydroxy-2-methylpropyl)-N-(5-((7-methoxyquinolin-4-yl)oxy)pyridin-2-yl)-5-methyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-carboxamide	Investigative	24764449	C30H29N5O5	539.6	CC1=C(C(=O)N(N1CC(C)(C)O)C2=CC=CC=C2)C(=O)NC3=NC=C(C=C3)OC4=C5C=CC(=CC5=NC=C4)OC	IC50 = 100000 nM	Poor binder
T23276	Extracellular signal-regulated kinase 1	B5ON0T	6-(1,9-Diazaspiro[5.5]undecan-9-Yl)-9h-Purine	Investigative	70789254	C14H20N6	272.35	C1CCNC2(C1)CCN(CC2)C3=NC=NC4=C3NC=N4	IC50 = 60000 nM	Poor binder
T23276	Extracellular signal-regulated kinase 1	B6TY8C	5-[3-Fluoro-4-[[6-methoxy-7-(3-morpholinopropoxy)quinolin-4-yl]oxy]phenyl]-2-(4-fluorophenylamino)-3-methylpyrimidin-4(3H)-one	Investigative	11858109	C34H33F2N5O5	629.7	CN1C(=O)C(=CN=C1NC2=CC=C(C=C2)F)C3=CC(=C(C=C3)OC4=C5C=C(C(=CC5=NC=C4)OCCCN6CCOCC6)OC)F	IC50 ~ 100000 nM	Poor binder
T23276	Extracellular signal-regulated kinase 1	B82MQJ	Aminopyrimidine amide, 13b	Investigative	16118737	C31H30F3N7O2	589.6	CC1=C(C=C(C=C1)NC(=O)C2=CC(=CC=C2)C(F)(F)F)C(=O)NC3=CN=C(N=C3)NC4=CC=C(C=C4)N5CCN(CC5)C	IC50 ~ 100000 nM	Poor binder
T23276	Extracellular signal-regulated kinase 1	BK6XI7	Meridianin E	Investigative	9995236	C12H9BrN4O	305.13	C1=CC(=C2C(=C1O)C(=CN2)C3=NC(=NC=C3)N)Br	IC50 ~ 100000 nM	Poor binder
T23276	Extracellular signal-regulated kinase 1	BPL30U	Lck Inhibitor	Investigative	11785878	C31H30N8O	530.6	CC1=C(C(=CC=C1)C)N2C(=O)C3=CN=C(N=C3N4C2=NC5=CC=CC=C54)NC6=CC=C(C=C6)N7CCN(CC7)C	IC50 ~ 100000 nM	Poor binder
T23276	Extracellular signal-regulated kinase 1	BQ1AM8	(4S,6E,12E)-18-Hydroxy-16-methoxy-4-methyl-3-oxabicyclo[12.4.0]octadeca-1(14),6,12,15,17-pentaene-2,8-dione	Investigative	49842666	C19H22O5	330.4	C[C@H]1C/C=C/C(=O)CCC/C=C/C2=C(C(=CC(=C2)OC)O)C(=O)O1	IC50 ~ 100000 nM	Poor binder
T23276	Extracellular signal-regulated kinase 1	BX0D4P	9-Isopropyl-N*6*-(3-methyl-but-2-enyl)-9H-purine-2,6-diamine	Investigative	44315929	C13H20N6	260.339	CC(C)N1C=NC2=C(N=C(N=C21)N)NCC=C(C)C	IC50 = 90000 nM	Poor binder
T23276	Extracellular signal-regulated kinase 1	BY06KG	4(3H)-Pyrimidinone,2-[(4-fluorophenyl)amino]-5-[5-[[6-methoxy-7-[3-(4-morpholinyl)propoxy]-4-quinolinyl]oxy]-2-pyridinyl]-3-methyl-	Investigative	24769780	C33H33FN6O5	612.6	CN1C(=O)C(=CN=C1NC2=CC=C(C=C2)F)C3=NC=C(C=C3)OC4=C5C=C(C(=CC5=NC=C4)OCCCN6CCOCC6)OC	IC50 ~ 100000 nM	Poor binder
T23276	Extracellular signal-regulated kinase 1	D04PEI	BMS-509744	Investigative	11467730	C32H41N5O4S2	623.8	CC1=CC(=C(C=C1SC2=CN=C(S2)NC(=O)C3=CC=C(C=C3)CNC(C)C(C)(C)C)C(=O)N4CCN(CC4)C(=O)C)OC	IC50 ~ 50000 nM	Poor binder
T23276	Extracellular signal-regulated kinase 1	D07OXC	AM7	Investigative	11650194	C35H35FN4O5	610.7	CN1C(=NC=C(C1=O)C2=CC(=C(C=C2)OC3=C4C=C(C(=CC4=NC=C3)OCCCN5CCOCC5)OC)F)CC6=CC=CC=C6	IC50 ~ 100000 nM	Poor binder
T23276	Extracellular signal-regulated kinase 1	D0V0QJ	NSC-686549	Investigative	389898	C14H8ClNO4	289.67	C1CC(=O)N(C1=O)C2=C(C(=O)C3=CC=CC=C3C2=O)Cl	IC50 = 82900 nM	Poor binder