TTD_Target_ID	Target_Name	TTD_Drug_ID	Drug_Name	Drug_Highest_Status	Drug_PubchemID	Molecular_Formula	Molecular_Weight	Canonical_SMILES	Activity	Binder_Type
T24836	Vitamin K-dependent protein C	D0I7OF	Hexamethylene amiloride	Preclinical	1794	C12H18ClN7O	311.77	C1CCCN(CC1)C2=NC(=C(N=C2Cl)C(=O)N=C(N)N)N	IC50 ~ 50000 nM	Poor binder
T24836	Vitamin K-dependent protein C	B0B7FQ	3-(4-Amidinophenyl)-2-[[[(4-amidinophenylsulfonyl)amino]acetyl]amino]propionic acid	Investigative	10095093	C19H22N6O5S	446.5	C1=CC(=CC=C1CC(C(=O)O)NC(=O)CNS(=O)(=O)C2=CC=C(C=C2)C(=N)N)C(=N)N	Ki = 180000 nM	Poor binder
T24836	Vitamin K-dependent protein C	B0JU5I	1-(3-Amino-1,2-benzoxazol-5-yl)-6-[4-(2-{[(3R)-3-hydroxypyrrolidin-1-yl]methyl}phenyl)phenyl]-3,5-dimethyl-1H,6H,7H-pyrazolo[4,3-d]pyrimidin-7-one	Investigative	16046153	C31H29N7O3	547.6	CC1=NN(C2=C1N=C(N(C2=O)C3=CC=C(C=C3)C4=CC=CC=C4CN5CC[C@H](C5)O)C)C6=CC7=C(C=C6)ON=C7N	Ki ~ 76000 nM	Poor binder
T24836	Vitamin K-dependent protein C	B1PMC4	Chembl4217043	Investigative	135393474	C17H23N9O2	385.4	COC1=NC=C(C=N1)C2=C(N=C(C(=N2)C(=O)N=C(N)N)N)N3CCCCCC3	IC50 ~ 50000 nM	Poor binder
T24836	Vitamin K-dependent protein C	B1Y2TO	3-[(R)-3-(4-Methanesulfonyl-piperazin-1-yl)-3-oxo-2-(2,2,5,7,8-pentamethyl-chroman-6-sulfonylamino)-propyl]-benzamidine	Investigative	44335624	C29H41N5O6S2	619.8	CC1=C(C(=C(C2=C1OC(CC2)(C)C)C)S(=O)(=O)N[C@H](CC3=CC(=CC=C3)C(=N)N)C(=O)N4CCN(CC4)S(=O)(=O)C)C	Ki = 180000 nM	Poor binder
T24836	Vitamin K-dependent protein C	B34UFB	6-{2-Fluoro-4-[2-(pyrrolidin-1-ylmethyl)phenyl]phenyl}-1-(4-methoxyphenyl)-7-oxo-1H,6H,7H-pyrazolo[4,3-d]pyrimidine-3-carboxamide	Investigative	20760195	C30H27FN6O3	538.6	COC1=CC=C(C=C1)N2C3=C(C(=N2)C(=O)N)N=CN(C3=O)C4=C(C=C(C=C4)C5=CC=CC=C5CN6CCCC6)F	Ki ~ 76000 nM	Poor binder
T24836	Vitamin K-dependent protein C	B3A0MQ	(3E,6S,9R,12S)-19-Chloro-9-cyclohexyl-12-(2-methylpropyl)-6-phenyl-8,11,14,23-tetrazatricyclo[14.7.0.017,22]tricosa-1(16),3,17(22),18,20-pentaene-7,10,13-trione	Investigative	52948297	C35H43ClN4O3	603.2	CC(C)C[C@H]1C(=O)NCC2=C(C/C=C/C[C@H](C(=O)N[C@@H](C(=O)N1)C3CCCCC3)C4=CC=CC=C4)NC5=C2C=C(C=C5)Cl	IC50 = 144500 nM	Poor binder
T24836	Vitamin K-dependent protein C	B4UJA1	(2R)-2-[[(2R)-2-[[2-[[2-[[2-[[(2S)-2-[[(1R,7S,10S,13S,16S,22S,25S,28S,40R,43S,46S,49S,52S,58S,61S)-40-Acetamido-43,52-bis(2-amino-2-oxoethyl)-13-(carboxymethyl)-46-[(1R)-1-hydroxyethyl]-10,49,61-tris(1H-indol-3-ylmethyl)-16-methyl-25-(2-methylpropyl)-2,8,11,14,17,23,26,41,44,47,50,53,59,62-tetradecaoxo-30,38,65-trithia-3,9,12,15,18,24,27,42,45,48,51,54,60,63-tetradecazahexacyclo[32.29.3.132,36.03,7.018,22.054,58]heptahexaconta-32,34,36(67)-triene-28-carbonyl]amino]propanoyl]-methylamino]acetyl]-methylamino]acetyl]-methylamino]acetyl]amino]-5-carbamimidamidopentanoyl]amino]-5-carbamimidamidopentanoic acid	Investigative	137637214	C117H160N32O28S3	2558.9	C[C@H]1C(=O)N2CCC[C@H]2C(=O)N[C@H](C(=O)N[C@H](CSCC3=CC4=CC(=C3)CSC[C@@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N5CCC[C@H]5C(=O)N[C@H](C(=O)N[C@@H](CSC4)C(=O)N6CCC[C@H]6C(=O)N[C@H](C(=O)N[C@H](C(=O)N1)CC(=O)O)CC7=CNC8=CC=CC=C87)CC9=CNC1=CC=CC=C19)CC(=O)N)CC1=CNC2=CC=CC=C21)[C@@H](C)O)CC(=O)N)NC(=O)C)C(=O)N[C@@H](C)C(=O)N(C)CC(=O)N(C)CC(=O)N(C)CC(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@H](CCCNC(=N)N)C(=O)O)CC(C)C	Ki ~ 50000 nM	Poor binder
T24836	Vitamin K-dependent protein C	B5VU7B	N-[(1s)-1-Benzyl-2-[2-[5-Chloro-2-(Tetrazol-1-Yl)phenyl]ethylamino]-2-Oxo-Ethyl]-4-Hydroxy-2-Oxo-1h-Quinoline-6-Carboxamide	Investigative	59402011	C28H24ClN7O4	558	C1=CC=C(C=C1)C[C@@H](C(=O)NCCC2=C(C=CC(=C2)Cl)N3C=NN=N3)NC(=O)C4=CC5=C(C=C4)NC(=O)C=C5O	Ki ~ 64000 nM	Poor binder
T24836	Vitamin K-dependent protein C	B82ILQ	1-(4-Methoxyphenyl)-7-oxo-6-{4-[2-(pyrrolidin-1-ylmethyl)phenyl]phenyl}-1H,6H,7H-pyrazolo[4,3-d]pyrimidine-3-carboxamide	Investigative	9809479	C30H28N6O3	520.6	COC1=CC=C(C=C1)N2C3=C(C(=N2)C(=O)N)N=CN(C3=O)C4=CC=C(C=C4)C5=CC=CC=C5CN6CCCC6	Ki ~ 76000 nM	Poor binder
T24836	Vitamin K-dependent protein C	B8LX9R	{1-[2-(4-Carbamimidoyl-benzylcarbamoyl)-indan-2-ylcarbamoyl]-cyclopentylamino}-acetic acid	Investigative	11849375	C26H31N5O4	477.6	C1CCC(C1)(C(=O)NC2(CC3=CC=CC=C3C2)C(=O)NCC4=CC=C(C=C4)C(=N)N)NCC(=O)O	IC50 = 53000 nM	Poor binder
T24836	Vitamin K-dependent protein C	BAUK64	(S)-Ethyl 1-(5-(4-phenethoxybenzyl)-1,2,4-oxadiazol-3-yl)-6-amino-1-oxohexan-2-ylcarbamate	Investigative	15984063	C26H32N4O5	480.6	CCOC(=O)N[C@@H](CCCCN)C(=O)C1=NOC(=N1)CC2=CC=C(C=C2)OCCC3=CC=CC=C3	Ki ~ 150000 nM	Poor binder
T24836	Vitamin K-dependent protein C	BD7M3X	3-(3-Amidinophenyl)-2-[[[(4-cyanophenylsulfonyl)amino]acetyl]amino]propionic acid ethyl ester	Investigative	11798089	C21H23N5O5S	457.5	CCOC(=O)C(CC1=CC(=CC=C1)C(=N)N)NC(=O)CNS(=O)(=O)C2=CC=C(C=C2)C#N	Ki = 80000 nM	Poor binder
T24836	Vitamin K-dependent protein C	BF7C4G	Chembl4228006	Investigative	70252985	C30H25ClN8O3	581	COC(=O)NC1=CC=C(C=C1)C2=CC(=NN=C2)[C@H](CC3=CC=CC=C3)NC(=O)/C=C/C4=C(C=CC(=C4)Cl)N5C=NN=N5	Ki = 68000 nM	Poor binder
T24836	Vitamin K-dependent protein C	BFJ41L	N-[4-Guanidino-1-(thiazole-2-carbonyl)-butyl]-2-[2-oxo-4-(quinoline-8-sulfonyl)-piperazin-1-yl]-acetamide	Investigative	44376417	C24H28N8O5S2	572.7	C1CN(C(=O)CN1S(=O)(=O)C2=CC=CC3=C2N=CC=C3)CC(=O)NC(CCCN=C(N)N)C(=O)C4=NC=CS4	IC50 ~ 180000 nM	Poor binder
T24836	Vitamin K-dependent protein C	BHAG94	(7R,10S,13S,21S,24S,27S,30S,33S,36S,39S,42S,45R)-7-Acetamido-36-(3-amino-3-oxopropyl)-13-benzyl-24-(4-carbamimidamidobutyl)-39-(carboxymethyl)-10-(hydroxymethyl)-21-[(4-hydroxyphenyl)methyl]-33-(1H-imidazol-5-ylmethyl)-30-methyl-42-(2-methylpropyl)-8,11,14,19,22,25,28,34,37,40,43-undecaoxo-5,47,52-trithia-9,12,15,20,23,26,29,32,35,38,41,44-dodecazatetracyclo[25.23.3.13,49.015,18]tetrapentaconta-1,3(54),49-triene-45-carboxylic acid	Investigative	137654508	C76H105N19O19S3	1685	C[C@H]1CN[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CSCC2=CC3=CC(=C2)CSC[C@@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N4CCC4C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](CSC3)C(=O)N1)CCCCNC(=N)N)CC5=CC=C(C=C5)O)CC6=CC=CC=C6)CO)NC(=O)C)C(=O)O)CC(C)C)CC(=O)O)CCC(=O)N)CC7=CN=CN7	Ki ~ 50000 nM	Poor binder
T24836	Vitamin K-dependent protein C	BIR2K1	3-[(R)-3-(4-Methyl-piperazin-1-yl)-2-(naphthalene-2-sulfonylamino)-3-oxo-propyl]-benzamidine	Investigative	10648370	C25H29N5O3S	479.6	CN1CCN(CC1)C(=O)[C@@H](CC2=CC(=CC=C2)C(=N)N)NS(=O)(=O)C3=CC4=CC=CC=C4C=C3	Ki = 94000 nM	Poor binder
T24836	Vitamin K-dependent protein C	BJ98LI	N-[(2S)-6-Amino-1-[5-[[4-[2-(3,4-dichlorophenyl)ethoxy]phenyl]methyl]-1,2,4-oxadiazol-3-yl]-1-oxohexan-2-yl]-3,4-difluorobenzamide;hydrochloride	Investigative	45263389	C30H29Cl3F2N4O4	653.9	C1=CC(=CC=C1CC2=NC(=NO2)C(=O)[C@H](CCCCN)NC(=O)C3=CC(=C(C=C3)F)F)OCCC4=CC(=C(C=C4)Cl)Cl.Cl	Ki ~ 150000 nM	Poor binder
T24836	Vitamin K-dependent protein C	BM6E3R	2-[4-(5-Chloro-3-methyl-benzo[b]thiophene-2-sulfonyl)-2-oxo-piperazin-1-yl]-N-[4-guanidino-1-(thiazole-2-carbonyl)-butyl]-acetamide	Investigative	44376328	C24H28ClN7O5S3	626.2	CC1=C(SC2=C1C=C(C=C2)Cl)S(=O)(=O)N3CCN(C(=O)C3)CC(=O)NC(CCCN=C(N)N)C(=O)C4=NC=CS4	IC50 = 169000 nM	Poor binder
T24836	Vitamin K-dependent protein C	BMA84P	Chembl4207715	Investigative	146029523	C20H22FN7O2	411.4	C1CCCN(CC1)C2=C(N=C(C(=N2)N)C(=O)N=C(N)N)C3=CC4=C(O3)C=CC=C4F	IC50 ~ 50000 nM	Poor binder
T24836	Vitamin K-dependent protein C	BP02UV	3-(3-Amidinophenyl)-2-[[[(4-amidinophenylsulfonyl)amino]acetyl]amino]propionic acid	Investigative	10718240	C19H22N6O5S	446.5	C1=CC(=CC(=C1)C(=N)N)CC(C(=O)O)NC(=O)CNS(=O)(=O)C2=CC=C(C=C2)C(=N)N	Ki = 180000 nM	Poor binder
T24836	Vitamin K-dependent protein C	BP7YS1	N-[2-(3-Carbamimidoylphenoxy)phenyl]-4-(2-sulfamoylphenyl)benzamide	Investigative	9826716	C26H22N4O4S	486.5	C1=CC=C(C(=C1)C2=CC=C(C=C2)C(=O)NC3=CC=CC=C3OC4=CC=CC(=C4)C(=N)N)S(=O)(=O)N	IC50 ~ 181000 nM	Poor binder
T24836	Vitamin K-dependent protein C	BQ0F9L	(2S)-N-[(5-Chloro-2-prop-2-enyl-1H-indol-3-yl)methyl]-2-[[(2R)-2-cyclohexyl-2-[[(2S)-2-phenylpent-4-enoyl]amino]acetyl]amino]-4-methylpentanamide	Investigative	52942903	C37H47ClN4O3	631.2	CC(C)C[C@@H](C(=O)NCC1=C(NC2=C1C=C(C=C2)Cl)CC=C)NC(=O)[C@@H](C3CCCCC3)NC(=O)[C@@H](CC=C)C4=CC=CC=C4	IC50 = 103500 nM	Poor binder
T24836	Vitamin K-dependent protein C	BQJ3R6	2-[4-(5-Chloro-naphthalene-2-sulfonyl)-2-oxo-piperazin-1-yl]-N-[4-guanidino-1-(thiazole-2-carbonyl)-butyl]-acetamide	Investigative	44376252	C25H28ClN7O5S2	606.1	C1CN(C(=O)CN1S(=O)(=O)C2=CC3=C(C=C2)C(=CC=C3)Cl)CC(=O)NC(CCCN=C(N)N)C(=O)C4=NC=CS4	IC50 = 170000 nM	Poor binder
T24836	Vitamin K-dependent protein C	BT32CJ	4-[(N-{(2e)-3-[5-Chloro-2-(1h-Tetrazol-1-Yl)phenyl]prop-2-Enoyl}-L-Phenylalanyl)amino]benzoic Acid	Investigative	25166809	C26H21ClN6O4	516.9	C1=CC=C(C=C1)C[C@@H](C(=O)NC2=CC=C(C=C2)C(=O)O)NC(=O)/C=C/C3=C(C=CC(=C3)Cl)N4C=NN=N4	Ki ~ 64000 nM	Poor binder
T24836	Vitamin K-dependent protein C	BUK51W	3-Azanyl-5-(azepan-1-yl)-6-(1-benzofuran-2-yl)-Ncarbamimidoyl-pyrazine-2-carboxamide	Investigative	135393470	C20H23N7O2	393.4	C1CCCN(CC1)C2=C(N=C(C(=N2)N)C(=O)N=C(N)N)C3=CC4=CC=CC=C4O3	IC50 ~ 50000 nM	Poor binder
T24836	Vitamin K-dependent protein C	BUM8R9	(3S)-N-[2'-(Aminosulfonyl)-4-biphenylyl]-2-(3-amidinobenzoyl)-1,2,3,4-tetrahydroisoquinoline-3alpha-carboxamide	Investigative	44331194	C30H27N5O4S	553.6	C1[C@H](N(CC2=CC=CC=C21)C(=O)C3=CC=CC(=C3)C(=N)N)C(=O)NC4=CC=C(C=C4)C5=CC=CC=C5S(=O)(=O)N	IC50 = 73000 nM	Poor binder
T24836	Vitamin K-dependent protein C	BWCN26	(2R)-2-[[(2R)-2-[[2-[[2-[[2-[[(2S)-2-[[(7R,10S,13S,16S,22S,25S,28S,31R,34S,37S,45S,48S,51R)-51-Acetamido-45-benzyl-10-[(2S)-butan-2-yl]-34-(4-carbamimidamidobutyl)-13-(carboxymethyl)-48-(hydroxymethyl)-22,25,37-tris[(4-hydroxyphenyl)methyl]-9,12,15,21,24,27,30,33,36,39,44,47,50-tridecaoxo-28-propan-2-yl-5,53,58-trithia-8,11,14,20,23,26,29,32,35,38,43,46,49-tridecazapentacyclo[29.25.3.13,55.016,20.040,43]hexaconta-1(56),2,55(60)-triene-7-carbonyl]amino]propanoyl]-methylamino]acetyl]-methylamino]acetyl]-methylamino]acetyl]amino]-5-carbamimidamidopentanoyl]amino]-5-carbamimidamidopentanoic acid	Investigative	137639385	C114H161N29O28S3	2481.9	CC[C@H](C)[C@H]1C(=O)N[C@@H](CSCC2=CC3=CC(=C2)CSC[C@@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N4CCC4C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CSC3)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N5CCC[C@H]5C(=O)N[C@H](C(=O)N1)CC(=O)O)CC6=CC=C(C=C6)O)CC7=CC=C(C=C7)O)C(C)C)CCCCNC(=N)N)CC8=CC=C(C=C8)O)CC9=CC=CC=C9)CO)NC(=O)C)C(=O)N[C@@H](C)C(=O)N(C)CC(=O)N(C)CC(=O)N(C)CC(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@H](CCCNC(=N)N)C(=O)O	Ki ~ 50000 nM	Poor binder
T24836	Vitamin K-dependent protein C	BWXE72	Chembl4227743	Investigative	88582319	C30H24Cl2N8O3	615.5	COC(=O)NC1=CC=C(C=C1)C2=CC(=NN=C2Cl)[C@H](CC3=CC=CC=C3)NC(=O)/C=C/C4=C(C=CC(=C4)Cl)N5C=NN=N5	Ki ~ 64400 nM	Poor binder
T24836	Vitamin K-dependent protein C	BZ15NL	Chembl4226631	Investigative	70253788	C31H27ClN8O3	595	CC1=NN=C(C=C1C2=CC=C(C=C2)NC(=O)OC)[C@H](CC3=CC=CC=C3)NC(=O)/C=C/C4=C(C=CC(=C4)Cl)N5C=NN=N5	Ki ~ 64400 nM	Poor binder
T24836	Vitamin K-dependent protein C	BZ60XH	N-[(R)-4-Guanidino-1-(thiazole-2-carbonyl)-butyl]-2-(2-oxo-4-phenylmethanesulfonyl-piperazin-1-yl)-acetamide	Investigative	44376426	C22H29N7O5S2	535.6	C1CN(C(=O)CN1S(=O)(=O)CC2=CC=CC=C2)CC(=O)N[C@H](CCCN=C(N)N)C(=O)C3=NC=CS3	IC50 ~ 180000 nM	Poor binder
T24836	Vitamin K-dependent protein C	BZ6T5B	N-[4-Guanidino-1-(thiazole-2-carbonyl)-butyl]-2-[4-(naphthalene-2-sulfonyl)-2-oxo-piperazin-1-yl]-acetamide	Investigative	20641745	C25H29N7O5S2	571.7	C1CN(C(=O)CN1S(=O)(=O)C2=CC3=CC=CC=C3C=C2)CC(=O)NC(CCCN=C(N)N)C(=O)C4=NC=CS4	IC50 ~ 180000 nM	Poor binder
T24836	Vitamin K-dependent protein C	BZL6P3	4-[[(2S)-2-[[(E)-3-[5-Chloro-2-(tetrazol-1-yl)phenyl]prop-2-enoyl]amino]-3-[4-[(4-methylpiperazine-1-carbonyl)amino]phenyl]propanoyl]amino]benzoic acid	Investigative	127027635	C32H32ClN9O5	658.1	CN1CCN(CC1)C(=O)NC2=CC=C(C=C2)C[C@@H](C(=O)NC3=CC=C(C=C3)C(=O)O)NC(=O)/C=C/C4=C(C=CC(=C4)Cl)N5C=NN=N5	Ki ~ 60000 nM	Poor binder
T24836	Vitamin K-dependent protein C	BZR0Y6	2-[4-(4-Chloro-benzenesulfonyl)-2-oxo-piperazin-1-yl]-N-[(R)-4-guanidino-1-(thiazole-2-carbonyl)-butyl]-acetamide	Investigative	44376100	C21H26ClN7O5S2	556.1	C1CN(C(=O)CN1S(=O)(=O)C2=CC=C(C=C2)Cl)CC(=O)N[C@H](CCCN=C(N)N)C(=O)C3=NC=CS3	IC50 ~ 180000 nM	Poor binder
T24836	Vitamin K-dependent protein C	D0Y5IQ	GRASSYSTATIN A	Investigative	44255320	C58H95N9O16	1174.4	C[C@H]([C@@H](C(=O)N[C@@H](C)C(=O)N(C)[C@H](CC1=CC=CC=C1)C(=O)N2CCC[C@H]2C(=O)OC)NC(=O)C[C@@H]([C@H](CC(C)C)NC(=O)[C@H](CC(=O)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](C(C)C)OC(=O)[C@H](C(C)C)OC(=O)[C@H](C(C)C)N(C)C)O)O	IC50 = 50000 nM	Poor binder