TTD_Target_ID	Target_Name	TTD_Drug_ID	Drug_Name	Drug_Highest_Status	Drug_PubchemID	Molecular_Formula	Molecular_Weight	Canonical_SMILES	Activity	Binder_Type
T25265	Enhancer of zeste homolog 2	B04YJS	3-Chloro-4-(2-cyanophenoxy)-N-(3,3-difluoro-2,2,6,6-tetramethylpiperidin-4-yl)benzamide	Investigative	90655840	C23H24ClF2N3O2	447.9	CC1(CC(C(C(N1)(C)C)(F)F)NC(=O)C2=CC(=C(C=C2)OC3=CC=CC=C3C#N)Cl)C	IC50 ~ 80000 nM	Poor binder
T25265	Enhancer of zeste homolog 2	B0XH7J	4-Benzoyl-N-(2,2,6,6-tetramethylpiperidin-4-yl)benzamide	Investigative	41676890	C23H28N2O2	364.5	CC1(CC(CC(N1)(C)C)NC(=O)C2=CC=C(C=C2)C(=O)C3=CC=CC=C3)C	IC50 = 57000 nM	Poor binder
T25265	Enhancer of zeste homolog 2	B1U3WS	(2S)-2-Amino-4-[[(2S,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methylsulfanyl]-N-[(1-ethylpyrazol-4-yl)methyl]butanamide	Investigative	118726589	C20H29N9O4S	491.6	CCN1C=C(C=N1)CNC(=O)[C@H](CCSC[C@@H]2[C@H]([C@H]([C@@H](O2)N3C=NC4=C(N=CN=C43)N)O)O)N	IC50 = 50000 nM	Poor binder
T25265	Enhancer of zeste homolog 2	B1WQ9E	(2S)-2-Amino-4-[[(2S,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methylsulfanyl]-N-[(5-methyl-6,7-dihydro-4H-pyrazolo[1,5-a]pyrazin-2-yl)methyl]butanamide	Investigative	118726595	C22H32N10O4S	532.6	CN1CCN2C(=CC(=N2)CNC(=O)[C@H](CCSC[C@@H]3[C@H]([C@H]([C@@H](O3)N4C=NC5=C(N=CN=C54)N)O)O)N)C1	IC50 = 50000 nM	Poor binder
T25265	Enhancer of zeste homolog 2	B24PKR	4-Anilino-N-(2,2,6,6-tetramethylpiperidin-4-yl)benzamide	Investigative	67679426	C22H29N3O	351.5	CC1(CC(CC(N1)(C)C)NC(=O)C2=CC=C(C=C2)NC3=CC=CC=C3)C	IC50 ~ 80000 nM	Poor binder
T25265	Enhancer of zeste homolog 2	B25TIV	4-(3-Methylphenoxy)-N-(2,2,6,6-tetramethylpiperidin-4-yl)benzamide	Investigative	57345180	C23H30N2O2	366.5	CC1=CC(=CC=C1)OC2=CC=C(C=C2)C(=O)NC3CC(NC(C3)(C)C)(C)C	IC50 = 61000 nM	Poor binder
T25265	Enhancer of zeste homolog 2	B36YSF	4-(Benzenesulfinyl)-N-(2,2,6,6-tetramethylpiperidin-4-yl)benzamide	Investigative	67679638	C22H28N2O2S	384.5	CC1(CC(CC(N1)(C)C)NC(=O)C2=CC=C(C=C2)S(=O)C3=CC=CC=C3)C	IC50 ~ 80000 nM	Poor binder
T25265	Enhancer of zeste homolog 2	B3B4KP	N-[(4,6-Dimethyl-2-oxo-1H-pyridin-3-yl)methyl]-1-propan-2-ylbenzimidazole-4-carboxamide	Investigative	127025970	C19H22N4O2	338.4	CC1=CC(=C(C(=O)N1)CNC(=O)C2=C3C(=CC=C2)N(C=N3)C(C)C)C	IC50 ~ 50000 nM	Poor binder
T25265	Enhancer of zeste homolog 2	B4V8DN	4-(2-Cyanophenoxy)-2-methoxy-N-(2,2,6,6-tetramethylpiperidin-4-yl)benzamide	Investigative	90655833	C24H29N3O3	407.5	CC1(CC(CC(N1)(C)C)NC(=O)C2=C(C=C(C=C2)OC3=CC=CC=C3C#N)OC)C	IC50 ~ 80000 nM	Poor binder
T25265	Enhancer of zeste homolog 2	B4X5RB	4-Phenoxy-N-(2,2,6,6-tetramethylpiperidin-4-yl)benzamide	Investigative	17533177	C22H28N2O2	352.5	CC1(CC(CC(N1)(C)C)NC(=O)C2=CC=C(C=C2)OC3=CC=CC=C3)C	IC50 = 51000 nM	Poor binder
T25265	Enhancer of zeste homolog 2	B6J3VZ	N-[(4,6-Dimethyl-2-oxo-1H-pyridin-3-yl)methyl]-1-propan-2-ylindazole-6-carboxamide	Investigative	127026273	C19H22N4O2	338.4	CC1=CC(=C(C(=O)N1)CNC(=O)C2=CC3=C(C=C2)C=NN3C(C)C)C	IC50 ~ 50000 nM	Poor binder
T25265	Enhancer of zeste homolog 2	B8FO3D	4-(2-Methoxyphenoxy)-N-(2,2,6,6-tetramethylpiperidin-4-yl)benzamide	Investigative	57345071	C23H30N2O3	382.5	CC1(CC(CC(N1)(C)C)NC(=O)C2=CC=C(C=C2)OC3=CC=CC=C3OC)C	IC50 = 59000 nM	Poor binder
T25265	Enhancer of zeste homolog 2	BBKS37	4-(1-Phenylcyclopropyl)-N-(2,2,6,6-tetramethylpiperidin-4-yl)benzamide	Investigative	67679501	C25H32N2O	376.5	CC1(CC(CC(N1)(C)C)NC(=O)C2=CC=C(C=C2)C3(CC3)C4=CC=CC=C4)C	IC50 ~ 80000 nM	Poor binder
T25265	Enhancer of zeste homolog 2	BBM61W	N-[(4,6-Dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl]-3-methoxybenzamide	Investigative	8243546	C16H18N2O3	286.33	CC1=CC(=C(C(=O)N1)CNC(=O)C2=CC(=CC=C2)OC)C	IC50 ~ 150000 nM	Poor binder
T25265	Enhancer of zeste homolog 2	BD2UB8	N-[(4,6-Dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl]-2,3-dimethoxybenzamide	Investigative	17397370	C17H20N2O4	316.35	CC1=CC(=C(C(=O)N1)CNC(=O)C2=C(C(=CC=C2)OC)OC)C	IC50 ~ 140000 nM	Poor binder
T25265	Enhancer of zeste homolog 2	BF92IR	4-(4-Methylphenoxy)-N-(2,2,6,6-tetramethylpiperidin-4-yl)benzamide	Investigative	67678991	C23H30N2O2	366.5	CC1=CC=C(C=C1)OC2=CC=C(C=C2)C(=O)NC3CC(NC(C3)(C)C)(C)C	IC50 ~ 80000 nM	Poor binder
T25265	Enhancer of zeste homolog 2	BGD73N	4-(N-Methylanilino)-N-(2,2,6,6-tetramethylpiperidin-4-yl)benzamide	Investigative	69671822	C23H31N3O	365.5	CC1(CC(CC(N1)(C)C)NC(=O)C2=CC=C(C=C2)N(C)C3=CC=CC=C3)C	IC50 ~ 80000 nM	Poor binder
T25265	Enhancer of zeste homolog 2	BI8F1L	3-Chloro-4-(2-cyano-3-pyridazin-4-ylphenoxy)-N-(2,2,6,6-tetramethyloxan-4-yl)benzamide	Investigative	69672489	C27H27ClN4O3	491	CC1(CC(CC(O1)(C)C)NC(=O)C2=CC(=C(C=C2)OC3=CC=CC(=C3C#N)C4=CN=NC=C4)Cl)C	IC50 = 66000 nM	Poor binder
T25265	Enhancer of zeste homolog 2	BIFA16	4-Phenylmethoxy-N-(2,2,6,6-tetramethylpiperidin-4-yl)benzamide	Investigative	41675187	C23H30N2O2	366.5	CC1(CC(CC(N1)(C)C)NC(=O)C2=CC=C(C=C2)OCC3=CC=CC=C3)C	IC50 ~ 80000 nM	Poor binder
T25265	Enhancer of zeste homolog 2	BJP1A8	6-Cyano-N-[(4,6-dimethyl-2-oxo-1H-pyridin-3-yl)methyl]-3-methyl-1-propan-2-yl-2,3-dihydroindole-4-carboxamide	Investigative	134135375	C22H26N4O2	378.5	CC1CN(C2=CC(=CC(=C12)C(=O)NCC3=C(C=C(NC3=O)C)C)C#N)C(C)C	IC50 ~ 100000 nM	Poor binder
T25265	Enhancer of zeste homolog 2	BK0MO7	(2S)-2-Amino-4-[[(2S,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methylsulfanyl]-N-(cyclopropylmethyl)butanamide	Investigative	118726586	C18H27N7O4S	437.5	C1CC1CNC(=O)[C@H](CCSC[C@@H]2[C@H]([C@H]([C@@H](O2)N3C=NC4=C(N=CN=C43)N)O)O)N	IC50 = 60000 nM	Poor binder
T25265	Enhancer of zeste homolog 2	BKGA28	3-Chloro-4-(2-cyanophenoxy)-N-[1-(2-hydroxyethyl)-2,2,6,6-tetramethylpiperidin-4-yl]benzamide	Investigative	90655839	C25H30ClN3O3	456	CC1(CC(CC(N1CCO)(C)C)NC(=O)C2=CC(=C(C=C2)OC3=CC=CC=C3C#N)Cl)C	IC50 = 62000 nM	Poor binder
T25265	Enhancer of zeste homolog 2	BMF9O6	4-(1-Phenylethyl)-N-(2,2,6,6-tetramethylpiperidin-4-yl)benzamide	Investigative	67679642	C24H32N2O	364.5	CC(C1=CC=CC=C1)C2=CC=C(C=C2)C(=O)NC3CC(NC(C3)(C)C)(C)C	IC50 ~ 80000 nM	Poor binder
T25265	Enhancer of zeste homolog 2	BPG14H	(2S)-2-Amino-4-[[(2S,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methylsulfanyl]-N-benzylbutanamide	Investigative	118726587	C21H27N7O4S	473.6	C1=CC=C(C=C1)CNC(=O)[C@H](CCSC[C@@H]2[C@H]([C@H]([C@@H](O2)N3C=NC4=C(N=CN=C43)N)O)O)N	IC50 = 120000 nM	Poor binder
T25265	Enhancer of zeste homolog 2	BQ6Z4R	N-[(4,6-Dimethyl-2-oxo-1H-pyridin-3-yl)methyl]-1-propan-2-ylbenzotriazole-4-carboxamide	Investigative	127026246	C18H21N5O2	339.4	CC1=CC(=C(C(=O)N1)CNC(=O)C2=C3C(=CC=C2)N(N=N3)C(C)C)C	IC50 ~ 50000 nM	Poor binder
T25265	Enhancer of zeste homolog 2	BT40VD	Ezh2-in-3	Investigative	69672582	C27H28ClN5O2	490	CC1(CC(CC(N1)(C)C)NC(=O)C2=CC(=C(C=C2)OC3=CC=CC(=C3C#N)C4=CN=NC=C4)Cl)C	IC50 = 58300 nM	Poor binder
T25265	Enhancer of zeste homolog 2	BTHW48	4-Benzyl-N-(2,2,6,6-tetramethylpiperidin-4-yl)benzamide	Investigative	69672405	C23H30N2O	350.5	CC1(CC(CC(N1)(C)C)NC(=O)C2=CC=C(C=C2)CC3=CC=CC=C3)C	IC50 ~ 80000 nM	Poor binder
T25265	Enhancer of zeste homolog 2	BU2TF9	4-(2-Cyanophenoxy)-3,5-dimethyl-N-(2,2,6,6-tetramethylpiperidin-4-yl)benzamide	Investigative	67679512	C25H31N3O2	405.5	CC1=CC(=CC(=C1OC2=CC=CC=C2C#N)C)C(=O)NC3CC(NC(C3)(C)C)(C)C	IC50 = 51000 nM	Poor binder
T25265	Enhancer of zeste homolog 2	BURB37	CC1=C(C(NC(=C1)C)=O)Cnc(C1=C(C(=CC=C1)OC)F)=O	Investigative	118324503	C16H17FN2O3	304.32	CC1=CC(=C(C(=O)N1)CNC(=O)C2=C(C(=CC=C2)OC)F)C	IC50 ~ 150000 nM	Poor binder
T25265	Enhancer of zeste homolog 2	BV0ES8	6-Cyano-1-cyclopentyl-N-[(4,6-dimethyl-2-oxo-1H-pyridin-3-yl)methyl]-3-methyl-2,3-dihydroindole-4-carboxamide	Investigative	134137743	C24H28N4O2	404.5	CC1CN(C2=CC(=CC(=C12)C(=O)NCC3=C(C=C(NC3=O)C)C)C#N)C4CCCC4	IC50 ~ 100000 nM	Poor binder
T25265	Enhancer of zeste homolog 2	BX6AM2	4-[Hydroxy(phenyl)methyl]-N-(2,2,6,6-tetramethylpiperidin-4-yl)benzamide	Investigative	67679164	C23H30N2O2	366.5	CC1(CC(CC(N1)(C)C)NC(=O)C2=CC=C(C=C2)C(C3=CC=CC=C3)O)C	IC50 ~ 80000 nM	Poor binder
T25265	Enhancer of zeste homolog 2	BY2E0H	1-Cyclopentyl-N-[(4,6-dimethyl-2-oxo-1H-pyridin-3-yl)methyl]indazole-6-carboxamide	Investigative	127029640	C21H24N4O2	364.4	CC1=CC(=C(C(=O)N1)CNC(=O)C2=CC3=C(C=C2)C=NN3C4CCCC4)C	IC50 ~ 50000 nM	Poor binder
T25265	Enhancer of zeste homolog 2	BZ6NP2	4-(Benzenesulfonyl)-N-(2,2,6,6-tetramethylpiperidin-4-yl)benzamide	Investigative	67679189	C22H28N2O3S	400.5	CC1(CC(CC(N1)(C)C)NC(=O)C2=CC=C(C=C2)S(=O)(=O)C3=CC=CC=C3)C	IC50 ~ 80000 nM	Poor binder