TTD_Target_ID	Target_Name	TTD_Drug_ID	Drug_Name	Drug_Highest_Status	Drug_PubchemID	Molecular_Formula	Molecular_Weight	Canonical_SMILES	Activity	Binder_Type
T27137	Metabotropic glutamate receptor 1	D00ENY	L-Glutamic Acid	Approved	33032	C5H9NO4	147.13	C(CC(=O)O)[C@@H](C(=O)O)N	EC50 = 156000 nM	Poor binder
T27137	Metabotropic glutamate receptor 1	D09YDQ	STX-107	Phase 2	9794218	C11H8N2S	200.26	CC1=NC(=CS1)C#CC2=CN=CC=C2	IC50 ~ 100000 nM	Poor binder
T27137	Metabotropic glutamate receptor 1	D0U5CS	LY354740	Discontinued in Phase 2	213056	C8H11NO4	185.18	C1C[C@]([C@H]2[C@@H]1[C@@H]2C(=O)O)(C(=O)O)N	Ki ~ 100000 nM	Poor binder
T27137	Metabotropic glutamate receptor 1	B1KEW7	(1S,2S,3S)-2-[1-Amino-1-carboxy-2-(9H-xanthen-9-yl)-ethyl]-3-propyl-cyclopropanecarboxylic acid	Investigative	44329024	C23H25NO5	395.4	CCC[C@@H]1[C@@H]([C@H]1C(CC2C3=CC=CC=C3OC4=CC=CC=C24)(C(=O)O)N)C(=O)O	IC50 ~ 100000 nM	Poor binder
T27137	Metabotropic glutamate receptor 1	B1VT5M	Iflwvshrwaivqf-sgihwfkdsa-	Investigative	9991661	C12H13NO4	235.24	C1=CC=C(C=C1)[C@H]2[C@H]([C@@H]2C(=O)O)[C@H](C(=O)O)N	Ki = 135000 nM	Poor binder
T27137	Metabotropic glutamate receptor 1	B1X7KZ	(1S,2S,3S)-2-[1-Amino-1-carboxy-2-(9H-xanthen-9-yl)-ethyl]-3-hexyl-cyclopropanecarboxylic acid	Investigative	44329031	C26H31NO5	437.5	CCCCCC[C@@H]1[C@@H]([C@H]1C(CC2C3=CC=CC=C3OC4=CC=CC=C24)(C(=O)O)N)C(=O)O	IC50 = 54900 nM	Poor binder
T27137	Metabotropic glutamate receptor 1	B2C6GP	5-(4-Chlorophenyl)-1-(cyclohexylmethyl)-6-methyl-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one	Investigative	44442427	C19H21ClN4O	356.8	CC1=NC2=C(C=NN2CC3CCCCC3)C(=O)N1C4=CC=C(C=C4)Cl	IC50 ~ 100000 nM	Poor binder
T27137	Metabotropic glutamate receptor 1	B3BD1R	2-[(1S,2R,3R)-2-Carboxy-3-phenylcyclopropyl]-D-glycine	Investigative	10513894	C12H13NO4	235.24	C1=CC=C(C=C1)[C@@H]2[C@@H]([C@@H]2C(=O)O)[C@H](C(=O)O)N	IC50 = 140000 nM	Poor binder
T27137	Metabotropic glutamate receptor 1	B45BXQ	(S)-2-Amino-4-(3,5-dioxo-[1,2,4]oxadiazolidin-2-yl)-butyric acid	Investigative	11820180	C6H9N3O5	203.15	C(CN1C(=O)NC(=O)O1)[C@@H](C(=O)O)N	Ki = 184000 nM	Poor binder
T27137	Metabotropic glutamate receptor 1	B4E2TO	4-(Amino-carboxy-methyl)-2-hydroxy-5-methyl-benzoic Acid	Investigative	10036599	C10H11NO5	225.2	CC1=CC(=C(C=C1C(C(=O)O)N)O)C(=O)O	IC50 = 73000 nM	Poor binder
T27137	Metabotropic glutamate receptor 1	B4JKT7	6-Methyl-1-phenyl-5-(4-(trifluoromethoxy)phenyl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one	Investigative	44442420	C19H13F3N4O2	386.3	CC1=NC2=C(C=NN2C3=CC=CC=C3)C(=O)N1C4=CC=C(C=C4)OC(F)(F)F	IC50 ~ 100000 nM	Poor binder
T27137	Metabotropic glutamate receptor 1	B4SK1A	(2S)-2-(3''-Carboxymethylbicyclo[1.1.1]pentyl)glycine	Investigative	44569859	C10H15NO4	213.23	C1C2(CC1(C2)CC(=O)O)C[C@@H](C(=O)O)N	Ki = 59000 nM	Poor binder
T27137	Metabotropic glutamate receptor 1	B54BWE	(2R,4R)-4-Amino-1-naphthalen-2-ylmethyl-pyrrolidine-2,4-dicarboxylic acid	Investigative	44302609	C17H18N2O4	314.34	C1[C@@H](N(C[C@]1(C(=O)O)N)CC2=CC3=CC=CC=C3C=C2)C(=O)O	IC50 = 133000 nM	Poor binder
T27137	Metabotropic glutamate receptor 1	B56RAI	2-(2,6-Dichloro-phenyl)-7-ethyl-5-(2-methoxy-phenyl)-5H-thiazolo[3,2-a]pyrimidine-6-carboxylic acid dimethylaminomethyl ester	Investigative	44322537	C25H25Cl2N3O3S	518.5	CCC1=C(C(N2C=C(SC2=N1)C3=C(C=CC=C3Cl)Cl)C4=CC=CC=C4OC)C(=O)OCN(C)C	Ki ~ 100000 nM	Poor binder
T27137	Metabotropic glutamate receptor 1	B6BH5N	4-Amino-2-thia-bicyclo[3.1.0]hexane-4,6-dicarboxylic acid	Investigative	10198133	C7H9NO4S	203.22	C1[C@]([C@@H]2[C@H]([C@@H]2S1)C(=O)O)(C(=O)O)N	EC50 ~ 100000 nM	Poor binder
T27137	Metabotropic glutamate receptor 1	B6YQR3	N,N-Diethyl-1-methyl-6-(pyridin-2-ylmethoxy)pyrazolo[3,4-b]pyrazine-3-carboxamide	Investigative	76332628	C17H20N6O2	340.4	CCN(CC)C(=O)C1=NN(C2=NC(=CN=C12)OCC3=CC=CC=N3)C	IC50 ~ 50000 nM	Poor binder
T27137	Metabotropic glutamate receptor 1	B76ASZ	[1-Methyl-6-(pyridin-2-ylmethoxy)pyrazolo[3,4-b]pyridin-3-yl]-morpholin-4-ylmethanone	Investigative	76332629	C18H19N5O3	353.4	CN1C2=C(C=CC(=N2)OCC3=CC=CC=N3)C(=N1)C(=O)N4CCOCC4	IC50 ~ 50000 nM	Poor binder
T27137	Metabotropic glutamate receptor 1	B7GQ1B	4-(6-Methyl-4-oxo-1-phenyl-1H-pyrazolo[3,4-d]pyrimidin-5(4H)-yl)benzenesulfonamide	Investigative	44442421	C18H15N5O3S	381.4	CC1=NC2=C(C=NN2C3=CC=CC=C3)C(=O)N1C4=CC=C(C=C4)S(=O)(=O)N	IC50 ~ 100000 nM	Poor binder
T27137	Metabotropic glutamate receptor 1	B7VM5K	trans-ACPD	Investigative	73537	C7H11NO4	173.17	C1C[C@@](C[C@H]1C(=O)O)(C(=O)O)N	EC50 = 127000 nM	Poor binder
T27137	Metabotropic glutamate receptor 1	B89BZX	(1S,2S,3R)-2-[(S)-Amino(carboxy)methyl]-3-cyclopropylcyclopropane-1-carboxylic acid	Investigative	46927956	C9H13NO4	199.2	C1CC1[C@@H]2[C@@H]([C@H]2C(=O)O)[C@@H](C(=O)O)N	EC50 ~ 100000 nM	Poor binder
T27137	Metabotropic glutamate receptor 1	B8B3PA	5-(4-Chlorophenyl)-6-methyl-1-(pyridin-2-yl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one	Investigative	44442433	C17H12ClN5O	337.8	CC1=NC2=C(C=NN2C3=CC=CC=N3)C(=O)N1C4=CC=C(C=C4)Cl	IC50 ~ 100000 nM	Poor binder
T27137	Metabotropic glutamate receptor 1	B8K6VC	(S)-4-(Amino(carboxy)methyl)cubane-1-carboxylic acid	Investigative	10198359	C11H11NO4	221.21	C12C3C4C1(C5C2C3(C45)C(=O)O)[C@@H](C(=O)O)N	IC50 = 76000 nM	Poor binder
T27137	Metabotropic glutamate receptor 1	BD93ST	2-[(1R,2R,3S)-2-Carboxy-3-phenylcyclopropyl]-L-glycine	Investigative	10489913	C12H13NO4	235.24	C1=CC=C(C=C1)[C@H]2[C@H]([C@@H]2C(=O)O)[C@@H](C(=O)O)N	Ki = 60000 nM	Poor binder
T27137	Metabotropic glutamate receptor 1	BDX52N	(1S,2S,3S)-2-[1-Amino-1-carboxy-2-(9H-xanthen-9-yl)-ethyl]-3-butyl-cyclopropanecarboxylic acid	Investigative	44328753	C24H27NO5	409.5	CCCC[C@@H]1[C@@H]([C@H]1C(CC2C3=CC=CC=C3OC4=CC=CC=C24)(C(=O)O)N)C(=O)O	IC50 = 57000 nM	Poor binder
T27137	Metabotropic glutamate receptor 1	BGI1S7	alpha-Methyl-4-carboxyphenylglycine	Investigative	1222	C10H11NO4	209.2	CC(C1=CC=C(C=C1)C(=O)O)(C(=O)O)N	Ki = 50000 nM	Poor binder
T27137	Metabotropic glutamate receptor 1	BH3E4M	(S)-4-((1-Carboxyethyl)amino)benzoic acid	Investigative	22884216	C10H11NO4	209.2	C[C@@H](C(=O)O)NC1=CC=C(C=C1)C(=O)O	IC50 = 57000 nM	Poor binder
T27137	Metabotropic glutamate receptor 1	BIGT98	(1R,2S,4R,5R)-2-Amino-bicyclo[2.1.1]hexane-2,5-dicarboxylic acid	Investigative	10775369	C8H11NO4	185.18	C1[C@@H]2C[C@]([C@H]1[C@@H]2C(=O)O)(C(=O)O)N	EC50 = 121000 nM	Poor binder
T27137	Metabotropic glutamate receptor 1	BJ59AS	Cyclopropaneacetic acid, alpha-amino-2-sulfo-, (alphaS,1S,2R)-	Investigative	17758554	C5H9NO5S	195.2	C1[C@H]([C@@H]1S(=O)(=O)O)[C@@H](C(=O)O)N	Ki = 77000 nM	Poor binder
T27137	Metabotropic glutamate receptor 1	BJ9L3T	(1S,2S,3S)-2-[1-Amino-1-carboxy-2-(9H-xanthen-9-yl)-ethyl]-3-ethyl-cyclopropanecarboxylic acid	Investigative	44329042	C22H23NO5	381.4	CC[C@@H]1[C@@H]([C@H]1C(CC2C3=CC=CC=C3OC4=CC=CC=C24)(C(=O)O)N)C(=O)O	IC50 ~ 100000 nM	Poor binder
T27137	Metabotropic glutamate receptor 1	BJSK27	1-Methyl-N-[(3-methyl-1,2-oxazol-5-yl)methyl]-6-(pyridin-2-ylmethoxy)pyrazolo[3,4-b]pyridine-3-carboxamide	Investigative	76318078	C19H18N6O3	378.4	CC1=NOC(=C1)CNC(=O)C2=NN(C3=C2C=CC(=N3)OCC4=CC=CC=N4)C	IC50 ~ 50000 nM	Poor binder
T27137	Metabotropic glutamate receptor 1	BK6I9B	2-[(3-Methylphenyl)amino]-7,8-dihydroquinazolin-5(6H)-one	Investigative	17228330	C15H15N3O	253.3	CC1=CC(=CC=C1)NC2=NC=C3C(=N2)CCCC3=O	IC50 ~ 100000 nM	Poor binder
T27137	Metabotropic glutamate receptor 1	BKY9E8	4-Carboxyphenylglycine	Investigative	5115	C9H9NO4	195.17	C1=CC(=CC=C1C(C(=O)O)N)C(=O)O	IC50 = 65000 nM	Poor binder
T27137	Metabotropic glutamate receptor 1	BL2OD9	6-Methyl-1,5-di(pyrazin-2-yl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one	Investigative	44442436	C14H10N8O	306.28	CC1=NC2=C(C=NN2C3=NC=CN=C3)C(=O)N1C4=NC=CN=C4	IC50 ~ 100000 nM	Poor binder
T27137	Metabotropic glutamate receptor 1	BPG7E9	(1S,2S,3S)-2-[1-Amino-1-carboxy-2-(9H-xanthen-9-yl)-ethyl]-3-phenethyl-cyclopropanecarboxylic acid	Investigative	10456810	C28H27NO5	457.5	C1=CC=C(C=C1)CC[C@@H]2[C@@H]([C@H]2C(CC3C4=CC=CC=C4OC5=CC=CC=C35)(C(=O)O)N)C(=O)O	IC50 ~ 100000 nM	Poor binder
T27137	Metabotropic glutamate receptor 1	BQK1P0	(1S,2S,3S)-2-[1-Amino-1-carboxy-2-(9H-xanthen-9-yl)-ethyl]-3-methyl-cyclopropanecarboxylic acid	Investigative	44328850	C21H21NO5	367.4	C[C@@H]1[C@@H]([C@H]1C(CC2C3=CC=CC=C3OC4=CC=CC=C24)(C(=O)O)N)C(=O)O	IC50 ~ 100000 nM	Poor binder
T27137	Metabotropic glutamate receptor 1	BQV60X	N-Ethyl-1-methyl-6-[(6-methylpyridin-2-yl)methoxy]pyrazolo[3,4-b]pyridine-3-carboxamide	Investigative	76321785	C17H19N5O2	325.4	CCNC(=O)C1=NN(C2=C1C=CC(=N2)OCC3=CC=CC(=N3)C)C	IC50 ~ 50000 nM	Poor binder
T27137	Metabotropic glutamate receptor 1	BRSO72	(S)-2-Amino-3-(4-butyl-3-hydroxy-isoxazol-5-yl)-propionic acid	Investigative	10263168	C10H16N2O4	228.24	CCCCC1=C(ONC1=O)C[C@@H](C(=O)O)N	Ki = 110000 nM	Poor binder
T27137	Metabotropic glutamate receptor 1	BS4J2I	N-(4-Fluorophenyl)-4,5,6,7-tetrahydro-1,3-benzothiazol-2-amine	Investigative	685051	C13H13FN2S	248.32	C1CCC2=C(C1)N=C(S2)NC3=CC=C(C=C3)F	IC50 = 64000 nM	Poor binder
T27137	Metabotropic glutamate receptor 1	BSX63D	(1S,2S,3S)-2-[1-Amino-1-carboxy-2-(9H-xanthen-9-yl)-ethyl]-3-isobutyl-cyclopropanecarboxylic acid	Investigative	44329033	C24H27NO5	409.5	CC(C)C[C@@H]1[C@@H]([C@H]1C(CC2C3=CC=CC=C3OC4=CC=CC=C24)(C(=O)O)N)C(=O)O	IC50 ~ 100000 nM	Poor binder
T27137	Metabotropic glutamate receptor 1	BV5UC8	(1S,2S,3R)-2-[(S)-Amino(carboxy)methyl]-3-cyclohexylcyclopropane-1-carboxylic acid	Investigative	52944782	C12H19NO4	241.28	C1CCC(CC1)[C@@H]2[C@@H]([C@H]2C(=O)O)[C@@H](C(=O)O)N	EC50 ~ 100000 nM	Poor binder
T27137	Metabotropic glutamate receptor 1	BWD4G0	5-(3-Chlorophenyl)-6-methyl-1-phenyl-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one	Investigative	697713	C18H13ClN4O	336.8	CC1=NC2=C(C=NN2C3=CC=CC=C3)C(=O)N1C4=CC(=CC=C4)Cl	IC50 ~ 100000 nM	Poor binder
T27137	Metabotropic glutamate receptor 1	BX3R5D	(RS)-4-Carboxy-3-hydroxyphenylglycine	Investigative	1297	C9H9NO5	211.17	C1=CC(=C(C=C1C(C(=O)O)N)O)C(=O)O	IC50 = 200000 nM	Poor binder
T27137	Metabotropic glutamate receptor 1	BXO13N	9-Dimethylamino-3-(4-cyclohexylphenyl)-3H-5-thia-1,3,6-triazafluoren-4-one	Investigative	11682866	C23H24N4OS	404.5	CN(C)C1=C2C3=C(C(=O)N(C=N3)C4=CC=C(C=C4)C5CCCCC5)SC2=NC=C1	IC50 ~ 100000 nM	Poor binder
T27137	Metabotropic glutamate receptor 1	BY1UF5	2-Amino-3-hydroxy-bicyclo[3.1.0]hexane-2,6-dicarboxylic acid(HYDIA)	Investigative	44322840	C8H11NO5	201.18	C1[C@H]([C@](C2C1[C@@H]2C(=O)O)(C(=O)O)N)O	Ki ~ 100000 nM	Poor binder
T27137	Metabotropic glutamate receptor 1	BZ10NG	2-(Amino-carboxy-methyl)-3-methyl-cyclopropanecarboxylic acid	Investigative	10176324	C7H11NO4	173.17	C[C@@H]1[C@@H]([C@H]1C(=O)O)[C@@H](C(=O)O)N	EC50 ~ 100000 nM	Poor binder
T27137	Metabotropic glutamate receptor 1	BZPS47	L-Homocysteic acid	Investigative	177491	C4H9NO5S	183.19	C(CS(=O)(=O)O)[C@@H](C(=O)O)N	Ki = 87000 nM	Poor binder
T27137	Metabotropic glutamate receptor 1	D05TFE	SIB-1757	Investigative	5218788	C12H11N3O	213.23	.	Ki ~ 100000 nM	Poor binder
T27137	Metabotropic glutamate receptor 1	D06PAK	LY-389795	Investigative	10058694	C7H9NO4S	203.22	C1[C@](C2[C@H](C2S1)C(=O)O)(C(=O)O)N	Ki ~ 100000 nM	Poor binder
T27137	Metabotropic glutamate receptor 1	D07GRG	LY-379268	Investigative	10197984	C7H9NO5	187.15	C1[C@]([C@@H]2[C@H]([C@@H]2O1)C(=O)O)(C(=O)O)N	Ki ~ 100000 nM	Poor binder
T27137	Metabotropic glutamate receptor 1	D09UBS	Ro64-5229	Investigative	10428048	C17H19Cl2N3O	352.3	C1CCCC(CC1)O/C(=C\\N2C=NC=N2)/C3=C(C=CC=C3Cl)Cl	Ki ~ 100000 nM	Poor binder
T27137	Metabotropic glutamate receptor 1	D0EK6P	(2R,4R)-4-aminopyrrolidine-2,4-dicarboxylate	Investigative	5310984	C6H10N2O4	174.15	C1[C@@H](NC[C@]1(C(=O)O)N)C(=O)O	Ki ~ 100000 nM	Poor binder
T27137	Metabotropic glutamate receptor 1	D0Q6VH	SIB-1893	Investigative	5311432	C14H13N	195.26	CC1=NC(=CC=C1)/C=C/C2=CC=CC=C2	Ki ~ 100000 nM	Poor binder