TTD_Target_ID	Target_Name	TTD_Drug_ID	Drug_Name	Drug_Highest_Status	Drug_PubchemID	Molecular_Formula	Molecular_Weight	Canonical_SMILES	Activity	Binder_Type
T30081	Thymidine kinase 1	B0EY5R	1-((2R,4R,5R)-5-Ethoxy-4-hydroxy-tetrahydro-furan-2-yl)-5-methyl-1H-pyrimidine-2,4-dione	Investigative	15227902	C11H16N2O5	256.25	CCO[C@H]1[C@@H](C[C@@H](O1)N2C=C(C(=O)NC2=O)C)O	IC50 ~ 50000 nM	Poor binder
T30081	Thymidine kinase 1	B3QZ7G	1-((2R,4R,5R)-5-Tert-Butoxy-4-hydroxy-tetrahydro-furan-2-yl)-5-methyl-1H-pyrimidine-2,4-dione	Investigative	15227906	C13H20N2O5	284.31	CC1=CN(C(=O)NC1=O)[C@H]2C[C@H]([C@@H](O2)OC(C)(C)C)O	IC50 ~ 50000 nM	Poor binder
T30081	Thymidine kinase 1	B3S9HV	1-((1R,3S,4S,6S)-4-Hydroxy-5-hydroxymethyl-bicyclo[3.1.0]hex-2-yl)-5-iodo-1H-pyrimidine-2,4-dione	Investigative	10406438	C11H13IN2O4	364.14	C1[C@@H]([C@H]2C[C@]2([C@H]1O)CO)N3C=C(C(=O)NC3=O)I	Ki = 85800 nM	Poor binder
T30081	Thymidine kinase 1	B4K5MP	1-((2R,4R,5R)-5-Benzyloxy-4-hydroxy-tetrahydro-furan-2-yl)-5-methyl-1H-pyrimidine-2,4-dione	Investigative	15227908	C16H18N2O5	318.32	CC1=CN(C(=O)NC1=O)[C@H]2C[C@H]([C@@H](O2)OCC3=CC=CC=C3)O	IC50 ~ 50000 nM	Poor binder
T30081	Thymidine kinase 1	B4W6FJ	2'-Deoxyguanosine	Investigative	135398592	C10H13N5O4	267.24	C1[C@@H]([C@H](O[C@H]1N2C=NC3=C2N=C(NC3=O)N)CO)O	IC50 = 115000 nM	Poor binder
T30081	Thymidine kinase 1	B59GDT	1-[(2R,4S,5S)-5-(Hydroxymethyl)-4-(4-phenyltriazol-1-yl)tetrahydrofuran-2-yl]-5-methyl-pyrimidine-2,4-dione	Investigative	14606828	C18H19N5O4	369.4	CC1=CN(C(=O)NC1=O)[C@H]2C[C@@H]([C@H](O2)CO)N3C=C(N=N3)C4=CC=CC=C4	IC50 = 54000 nM	Poor binder
T30081	Thymidine kinase 1	B5CWR2	1-(4,5-Dihydroxy-tetrahydro-furan-2-yl)-5-methylsulfanyl-1H-pyrimidin-2-one	Investigative	44269001	C9H12N2O4S	244.27	CSC1=CN(C(=O)N=C1)C2CC(C(O2)O)O	Ki = 160000 nM	Poor binder
T30081	Thymidine kinase 1	B5S3FB	1-[(2R,4S,5S)-4-(4-Benzyltriazol-1-yl)-5-(hydroxymethyl)tetrahydrofuran-2-yl]-5-methyl-pyrimidine-2,4-dione	Investigative	46885301	C19H21N5O4	383.4	CC1=CN(C(=O)NC1=O)[C@H]2C[C@@H]([C@H](O2)CO)N3C=C(N=N3)CC4=CC=CC=C4	IC50 = 78000 nM	Poor binder
T30081	Thymidine kinase 1	B7XWB1	1-((2R,4R,5R)-4-Hydroxy-5-propoxy-tetrahydro-furan-2-yl)-5-methyl-1H-pyrimidine-2,4-dione	Investigative	15227904	C12H18N2O5	270.28	CCCO[C@H]1[C@@H](C[C@@H](O1)N2C=C(C(=O)NC2=O)C)O	IC50 ~ 50000 nM	Poor binder
T30081	Thymidine kinase 1	B87PUD	1-((2R,4R,5R)-4-Hydroxy-5-methoxy-tetrahydro-furan-2-yl)-5-methyl-1H-pyrimidine-2,4-dione	Investigative	15227900	C10H14N2O5	242.23	CC1=CN(C(=O)NC1=O)[C@H]2C[C@H]([C@@H](O2)OC)O	IC50 ~ 50000 nM	Poor binder
T30081	Thymidine kinase 1	B89PUQ	3'-Azido-3'-deoxy-4-thiothymidine	Investigative	3000254	C10H13N5O3S	283.31	CC1=CN(C(=O)NC1=S)[C@H]2C[C@@H]([C@H](O2)CO)N=[N+]=[N-]	Ki = 54000 nM	Poor binder
T30081	Thymidine kinase 1	B91UYV	1-[(Z)-4-(Diphenylacetylamino)-2-butenyl]-5-methyl-1,2,3,4-tetrahydropyrimidine-2,4-dione	Investigative	44333745	C23H23N3O3	389.4	CC1=CN(C(=O)NC1=O)C/C=C\\CNC(=O)C(C2=CC=CC=C2)C3=CC=CC=C3	IC50 = 115000 nM	Poor binder
T30081	Thymidine kinase 1	BA8T2M	3''-(4-(2-Pyridine)-1,2,3-triazole-1-yl)-2''-deoxythymidine	Investigative	452395	C17H18N6O4	370.4	CC1=CN(C(=O)NC1=O)[C@H]2C[C@@H]([C@H](O2)CO)N3C=C(N=N3)C4=CC=CC=N4	IC50 = 53000 nM	Poor binder
T30081	Thymidine kinase 1	BBX3S5	1-[(Z)-4-(4-Chlorophenylacetylamino)-2-butenyl]-5-methyl-1,2,3,4-tetrahydropyrimidine-2,4-dione	Investigative	44333420	C17H18ClN3O3	347.8	CC1=CN(C(=O)NC1=O)C/C=C\\CNC(=O)CC2=CC=C(C=C2)Cl	IC50 = 198000 nM	Poor binder
T30081	Thymidine kinase 1	BD0GZ7	1-[(Z)-4-(4-Biphenylylacetylamino)-2-butenyl]-5-methyl-1,2,3,4-tetrahydropyrimidine-2,4-dione	Investigative	44333760	C23H23N3O3	389.4	CC1=CN(C(=O)NC1=O)C/C=C\\CNC(=O)CC2=CC=C(C=C2)C3=CC=CC=C3	IC50 = 119000 nM	Poor binder
T30081	Thymidine kinase 1	BDR5Q7	1-((2R,4R,5R)-4-Hydroxy-5-phenethyloxy-tetrahydro-furan-2-yl)-5-methyl-1H-pyrimidine-2,4-dione	Investigative	44286741	C17H20N2O5	332.4	CC1=CN(C(=O)NC1=O)[C@H]2C[C@H]([C@@H](O2)OCCC3=CC=CC=C3)O	IC50 ~ 50000 nM	Poor binder
T30081	Thymidine kinase 1	BF9M7V	1-[(2R,4R,5R)-4-Hydroxy-5-(3-phenyl-propoxy)-tetrahydro-furan-2-yl]-5-methyl-1H-pyrimidine-2,4-dione	Investigative	44286784	C18H22N2O5	346.4	CC1=CN(C(=O)NC1=O)[C@H]2C[C@H]([C@@H](O2)OCCCC3=CC=CC=C3)O	IC50 ~ 50000 nM	Poor binder
T30081	Thymidine kinase 1	BG8SA9	5-Bromo-1-((1R,3S,4S,6S)-4-hydroxy-5-hydroxymethyl-bicyclo[3.1.0]hex-2-yl)-1H-pyrimidine-2,4-dione	Investigative	11438492	C11H13BrN2O4	317.14	C1[C@@H]([C@H]2C[C@]2([C@H]1O)CO)N3C=C(C(=O)NC3=O)Br	Ki = 69800 nM	Poor binder
T30081	Thymidine kinase 1	BGMR97	1-((2R,4S,5S)-5-Ethoxy-4-hydroxy-tetrahydro-furan-2-yl)-5-methyl-1H-pyrimidine-2,4-dione	Investigative	15227901	C11H16N2O5	256.25	CCO[C@@H]1[C@H](C[C@@H](O1)N2C=C(C(=O)NC2=O)C)O	IC50 = 50000 nM	Poor binder
T30081	Thymidine kinase 1	BGQV18	1-[(Z)-4-(9H-Xanthene-9-ylcarbonylamino)-2-butenyl]-5-methyl-1,2,3,4-tetrahydropyrimidine-2,4-dione	Investigative	44333373	C23H21N3O4	403.4	CC1=CN(C(=O)NC1=O)C/C=C\\CNC(=O)C2C3=CC=CC=C3OC4=CC=CC=C24	IC50 = 131000 nM	Poor binder
T30081	Thymidine kinase 1	BI03JU	3''-(4-Cyclopentylmethyl-1,2,3-triazol-1-yl)-3''-deoxy-beta-D-thymidine	Investigative	46885302	C18H25N5O4	375.4	CC1=CN(C(=O)NC1=O)[C@H]2C[C@@H]([C@H](O2)CO)N3C=C(N=N3)CC4CCCC4	IC50 = 177000 nM	Poor binder
T30081	Thymidine kinase 1	BIPA32	5-(2-Bromo-vinyl)-1-((1S,2S,4S,5R)-4-hydroxy-5-hydroxymethyl-bicyclo[3.1.0]hex-2-yl)-1H-pyrimidine-2,4-dione	Investigative	9906078	C13H15BrN2O4	343.17	C1[C@@H]([C@H]2C[C@]2([C@H]1O)CO)N3C=C(C(=O)NC3=O)/C=C/Br	Ki = 62900 nM	Poor binder
T30081	Thymidine kinase 1	BL2K8U	1-((2R,4S,5S)-4-Hydroxy-5-propoxy-tetrahydro-furan-2-yl)-5-methyl-1H-pyrimidine-2,4-dione	Investigative	15227903	C12H18N2O5	270.28	CCCO[C@@H]1[C@H](C[C@@H](O1)N2C=C(C(=O)NC2=O)C)O	IC50 ~ 50000 nM	Poor binder
T30081	Thymidine kinase 1	BL7DX6	1-[(2R,4S,5S)-4-[5-(4-Chlorophenyl)triazol-1-yl]-5-(hydroxymethyl)tetrahydrofuran-2-yl]-5-methyl-pyrimidine-2,4-dione	Investigative	46884567	C18H18ClN5O4	403.8	CC1=CN(C(=O)NC1=O)[C@H]2C[C@@H]([C@H](O2)CO)N3C(=CN=N3)C4=CC=C(C=C4)Cl	IC50 = 109000 nM	Poor binder
T30081	Thymidine kinase 1	BL7H5F	1-[4-(4-Benzyl-piperazin-1-yl)-but-2-enyl]-5-methyl-1H-pyrimidine-2,4-dione	Investigative	44333414	C20H26N4O2	354.4	CC1=CN(C(=O)NC1=O)C/C=C\\CN2CCN(CC2)CC3=CC=CC=C3	IC50 = 180000 nM	Poor binder
T30081	Thymidine kinase 1	BN5MI9	1-[(2R,4S,5R)-5-(Hydroxymethyl)-4-(methyldisulfanyl)oxolan-2-yl]-5-methylpyrimidine-2,4-dione	Investigative	506492	C11H16N2O4S2	304.4	CC1=CN(C(=O)NC1=O)[C@H]2C[C@@H]([C@H](O2)CO)SSC	IC50 = 73000 nM	Poor binder
T30081	Thymidine kinase 1	BNU3A1	1-((2R,4S,5S)-5-Tert-Butoxy-4-hydroxy-tetrahydro-furan-2-yl)-5-methyl-1H-pyrimidine-2,4-dione	Investigative	15227905	C13H20N2O5	284.31	CC1=CN(C(=O)NC1=O)[C@H]2C[C@@H]([C@H](O2)OC(C)(C)C)O	IC50 ~ 50000 nM	Poor binder
T30081	Thymidine kinase 1	BP58GV	1-(4-Aminomethyl-3-hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-5-methyl-1H-pyrimidine-2,4-dione	Investigative	508216	C11H17N3O5	271.27	CC1=CN(C(=O)NC1=O)[C@H]2[C@@H]([C@@H]([C@H](O2)CO)CN)O	Ki = 110000 nM	Poor binder
T30081	Thymidine kinase 1	BU82QD	1-(4-Benzylamino-but-2-enyl)-5-methyl-1H-pyrimidine-2,4-dione	Investigative	9971180	C16H19N3O2	285.34	CC1=CN(C(=O)NC1=O)C/C=C\\CNCC2=CC=CC=C2	IC50 = 57000 nM	Poor binder
T30081	Thymidine kinase 1	BUWQ65	1-[(2R,4S,5S)-4-[4-(3,4-Dichlorophenyl)triazol-1-yl]-5-(hydroxymethyl)tetrahydrofuran-2-yl]-5-methyl-pyrimidine-2,4-dione	Investigative	46884565	C18H17Cl2N5O4	438.3	CC1=CN(C(=O)NC1=O)[C@H]2C[C@@H]([C@H](O2)CO)N3C=C(N=N3)C4=CC(=C(C=C4)Cl)Cl	IC50 = 75000 nM	Poor binder
T30081	Thymidine kinase 1	BV25YE	3''-(4-(3-Chloro-propyl)-1,2,3-triazol-1-yl)-3''-deoxythymidine	Investigative	46888106	C15H21N5O4	335.36	CCCC1=CN(N=N1)[C@H]2C[C@@H](O[C@@H]2CO)N3C=C(C(=O)NC3=O)C	IC50 = 105000 nM	Poor binder
T30081	Thymidine kinase 1	BVGX68	3''-(4-Tert-Butyl-1,2,3-triazol-1-yl)-3''-deoxythymidine	Investigative	46888108	C16H23N5O4	349.38	CC1=CN(C(=O)NC1=O)[C@H]2C[C@@H]([C@H](O2)CO)N3C=C(N=N3)C(C)(C)C	IC50 = 114000 nM	Poor binder
T30081	Thymidine kinase 1	BW1BH7	1-[(Z)-4-[3-(Trifluoromethyl)benzoylamino]-2-butenyl]-5-methyl-1,2,3,4-tetrahydropyrimidine-2,4-dione	Investigative	44333378	C17H16F3N3O3	367.32	CC1=CN(C(=O)NC1=O)C/C=C\\CNC(=O)C2=CC(=CC=C2)C(F)(F)F	IC50 = 72000 nM	Poor binder
T30081	Thymidine kinase 1	BXT8S5	3''-(4-Pentyl-1,2,3-triazol-1-yl)-3''-deoxythymidine	Investigative	46888151	C15H20ClN5O4	369.8	CC1=CN(C(=O)NC1=O)[C@H]2C[C@@H]([C@H](O2)CO)N3C=C(N=N3)CCCCl	IC50 = 86000 nM	Poor binder
T30081	Thymidine kinase 1	BXVE86	1-((2R,4S,5S)-5-Benzyloxy-4-hydroxy-tetrahydro-furan-2-yl)-5-methyl-1H-pyrimidine-2,4-dione	Investigative	15227907	C16H18N2O5	318.32	CC1=CN(C(=O)NC1=O)[C@H]2C[C@@H]([C@H](O2)OCC3=CC=CC=C3)O	IC50 ~ 50000 nM	Poor binder
T30081	Thymidine kinase 1	BYF58T	1-[(2R,4S,5S)-5-(Hydroxymethyl)-4-[4-(2-phenylethyl)triazol-1-yl]oxolan-2-yl]-5-methylpyrimidine-2,4-dione	Investigative	46888152	C20H23N5O4	397.4	CC1=CN(C(=O)NC1=O)[C@H]2C[C@@H]([C@H](O2)CO)N3C=C(N=N3)CCC4=CC=CC=C4	IC50 = 60000 nM	Poor binder
T30081	Thymidine kinase 1	BZK8J1	1-[(2R,4S,5S)-4-[4-(4-Chlorophenyl)triazol-1-yl]-5-(hydroxymethyl)tetrahydrofuran-2-yl]-5-methyl-pyrimidine-2,4-dione	Investigative	46884564	C18H18ClN5O4	403.8	CC1=CN(C(=O)NC1=O)[C@H]2C[C@@H]([C@H](O2)CO)N3C=C(N=N3)C4=CC=C(C=C4)Cl	IC50 = 71000 nM	Poor binder