TTD_Target_ID	Target_Name	TTD_Drug_ID	Drug_Name	Drug_Highest_Status	Drug_PubchemID	Molecular_Formula	Molecular_Weight	Canonical_SMILES	Activity	Binder_Type
T31424	Adrenergic receptor Alpha-2	B0LXN3	5-O-[2-[[(3S)-2,3-Dihydro-1,4-benzodioxin-3-yl]methyl-methylamino]ethyl] 3-O-methyl (4R)-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate;hydrochloride	Investigative	14548276	C28H32ClN3O8	574	CC1=C([C@H](C(=C(N1)C)C(=O)OCCN(C)C[C@H]2COC3=CC=CC=C3O2)C4=CC(=CC=C4)[N+](=O)[O-])C(=O)OC.Cl	IC50 ~ 100000 nM	Poor binder
T31424	Adrenergic receptor Alpha-2	B2LN0P	Chembl4129015	Investigative	145960502	C13H20ClN3O2S	317.84	CCOC(=O)C1=C(SC2=C1CCCCC2)N=C(N)N.Cl	Ki ~ 100000 nM	Poor binder
T31424	Adrenergic receptor Alpha-2	B2XGK8	3-[2-[4-Phenyl-1-piperazinyl]ethyl]-1H-pyrimido[5,4-b]indole-2,4(3H,5H)-dione	Investigative	15054187	C22H23N5O2	389.4	C1CN(CCN1CCN2C(=O)C3=C(C4=CC=CC=C4N3)NC2=O)C5=CC=CC=C5	Ki ~ 100000 nM	Poor binder
T31424	Adrenergic receptor Alpha-2	B5CH4I	N-(1,3-Benzodioxol-5-yl)-4,5-dihydro-1H-imidazol-2-amine	Investigative	3086489	C10H11N3O2	205.21	C1CN=C(N1)NC2=CC3=C(C=C2)OCO3	EC50 = 141000 nM	Poor binder
T31424	Adrenergic receptor Alpha-2	B70NVF	N-(7-Chloro-2,3-dihydro-1H-inden-4-yl)-2-methyl-3,4-dihydro-2H-pyrrol-5-amine	Investigative	70980467	C14H17ClN2	248.75	CC1CCC(=N1)NC2=C3CCCC3=C(C=C2)Cl	Ki ~ 100000 nM	Poor binder
T31424	Adrenergic receptor Alpha-2	B7Y0VQ	2-[4-(Methylamino)phenyl]guanidine	Investigative	25209671	C8H12N4	164.21	CNC1=CC=C(C=C1)N=C(N)N	EC50 = 82300 nM	Poor binder
T31424	Adrenergic receptor Alpha-2	B8GTP2	Chembl4127048	Investigative	145962999	C7H10ClN3O2S	235.69	COC(=O)C1=C(C=CS1)N=C(N)N.Cl	Ki ~ 100000 nM	Poor binder
T31424	Adrenergic receptor Alpha-2	B93YNS	Chembl4128195	Investigative	145961752	C7H10ClN3O2S	235.69	COC(=O)C1=C(SC=C1)N=C(N)N.Cl	Ki ~ 100000 nM	Poor binder
T31424	Adrenergic receptor Alpha-2	B9S1IY	N-(2-Chlorophenyl)-2-methyl-3,4-dihydro-2H-pyrrol-5-amine	Investigative	70686398	C11H13ClN2	208.69	CC1CCC(=N1)NC2=CC=CC=C2Cl	Ki ~ 100000 nM	Poor binder
T31424	Adrenergic receptor Alpha-2	B9TL8E	4,4'-Di(2-imidazolidinylimino)diphenyl ether	Investigative	17755537	C18H20N6O	336.4	C1CN=C(N1)NC2=CC=C(C=C2)OC3=CC=C(C=C3)NC4=NCCN4	EC50 = 120000 nM	Poor binder
T31424	Adrenergic receptor Alpha-2	BBFV14	2-(1,4-Benzodioxan-6-ylamino)-2-imidazoline	Investigative	3086247	C11H13N3O2	219.24	C1CN=C(N1)NC2=CC3=C(C=C2)OCCO3	EC50 = 56400 nM	Poor binder
T31424	Adrenergic receptor Alpha-2	BBZR29	2-Pyridin-3-ylguanidine;hydrochloride	Investigative	118730390	C6H9ClN4	172.61	C1=CC(=CN=C1)N=C(N)N.Cl	Ki = 162181.01 nM	Poor binder
T31424	Adrenergic receptor Alpha-2	BD40VI	3-[2-[4-(4-Methoxyphenyl)-1-piperazinyl]ethyl]-1H-pyrimido[5,4-b]indole-2,4(3H,5H)-dione	Investigative	15054190	C23H25N5O3	419.5	COC1=CC=C(C=C1)N2CCN(CC2)CCN3C(=O)C4=C(C5=CC=CC=C5N4)NC3=O	Ki ~ 100000 nM	Poor binder
T31424	Adrenergic receptor Alpha-2	BDMS63	4-[(1,2,3,4-Tetrahydrophenanthren)-4-yl]-1H-imidazole	Investigative	10658207	C17H16N2	248.32	C1CC(C2=C(C1)C=CC3=CC=CC=C32)C4=CN=CN4	IC50 = 97700 nM	Poor binder
T31424	Adrenergic receptor Alpha-2	BJN8E6	3-[2-[4-(2-Chlorophenyl)-1-piperazinyl]ethyl]-1H-pyrimido[5,4-b]indole-2,4(3H,5H)-dione	Investigative	15054191	C22H22ClN5O2	423.9	C1CN(CCN1CCN2C(=O)C3=C(C4=CC=CC=C4N3)NC2=O)C5=CC=CC=C5Cl	Ki ~ 100000 nM	Poor binder
T31424	Adrenergic receptor Alpha-2	BKX03H	N-(7-Chloro-2,3-dihydro-1H-inden-4-yl)-3-methyl-3,4-dihydro-2H-pyrrol-5-amine	Investigative	66571032	C14H17ClN2	248.75	CC1CC(=NC1)NC2=C3CCCC3=C(C=C2)Cl	Ki ~ 100000 nM	Poor binder
T31424	Adrenergic receptor Alpha-2	BLI81M	4-N-(4,5-Dihydro-1H-imidazol-2-yl)-1-N-methylbenzene-1,4-diamine	Investigative	25209507	C10H14N4	190.25	CNC1=CC=C(C=C1)NC2=NCCN2	EC50 = 61400 nM	Poor binder
T31424	Adrenergic receptor Alpha-2	BN1O8G	4-N-(4,5-Dihydro-1H-imidazol-2-yl)-1-N-ethylbenzene-1,4-diamine	Investigative	25209509	C11H16N4	204.27	CCNC1=CC=C(C=C1)NC2=NCCN2	EC50 = 59300 nM	Poor binder
T31424	Adrenergic receptor Alpha-2	BN38XZ	3-Methyl-N-(7-methyl-2,3-dihydro-1H-inden-4-yl)-3,4-dihydro-2H-pyrrol-5-amine	Investigative	66571033	C15H20N2	228.33	CC1CC(=NC1)NC2=C3CCCC3=C(C=C2)C	Ki ~ 100000 nM	Poor binder
T31424	Adrenergic receptor Alpha-2	BN73ZC	N-(4-Methylpyrrolidine-2-ylidene)-2-methyl-3-chloroaniline	Investigative	66570978	C12H15ClN2	222.71	CC1CC(=NC1)NC2=C(C(=CC=C2)Cl)C	Ki ~ 100000 nM	Poor binder
T31424	Adrenergic receptor Alpha-2	BNM94B	2-(1,4-Dihydroquinazolin-2-ylamino)ethanol;hydrochloride	Investigative	118730518	C10H14ClN3O	227.69	C1C2=CC=CC=C2NC(=N1)NCCO.Cl	EC50 = 60340 nM	Poor binder
T31424	Adrenergic receptor Alpha-2	BPWH63	2-[5-(Ethylamino)pyridin-2-yl]guanidine;hydrochloride	Investigative	118730388	C8H14ClN5	215.68	CCNC1=CN=C(C=C1)N=C(N)N.Cl	Ki = 75857.76 nM	Poor binder
T31424	Adrenergic receptor Alpha-2	BPX34K	3-[2-[4-(4-Chlorophenyl)-1-piperazinyl]ethyl]-1H-pyrimido[5,4-b]indole-2,4(3H,5H)-dione	Investigative	15054192	C22H22ClN5O2	423.9	C1CN(CCN1CCN2C(=O)C3=C(C4=CC=CC=C4N3)NC2=O)C5=CC=C(C=C5)Cl	Ki ~ 100000 nM	Poor binder
T31424	Adrenergic receptor Alpha-2	BVLY27	Chembl4126954	Investigative	145962555	C9H14ClN3O2S	263.75	CCOC(=O)C1=C(SC=C1C)N=C(N)N.Cl	Ki = 66530 nM	Poor binder
T31424	Adrenergic receptor Alpha-2	BYJ84Q	N-(2,3-Dihydro-1H-inden-4-yl)-2-methyl-3,4-dihydro-2H-pyrrol-5-amine	Investigative	66571029	C14H18N2	214.31	CC1CCC(=N1)NC2=CC=CC3=C2CCC3	Ki ~ 100000 nM	Poor binder
T31424	Adrenergic receptor Alpha-2	BZ4KJ8	5-O-[2-[[Cyclohexyl(phenyl)methyl]-methylamino]ethyl] 3-O-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate;hydrochloride	Investigative	14548290	C32H40ClN3O6	598.1	CC1=C(C(C(=C(N1)C)C(=O)OCCN(C)C(C2CCCCC2)C3=CC=CC=C3)C4=CC(=CC=C4)[N+](=O)[O-])C(=O)OC.Cl	IC50 ~ 100000 nM	Poor binder
T31424	Adrenergic receptor Alpha-2	D0H1WR	SK&F-29661	Investigative	5226	C9H12N2O2S	212.27	C1CNCC2=C1C=CC(=C2)S(=O)(=O)N	Ki = 100000 nM	Poor binder