TTD_Target_ID	Target_Name	TTD_Drug_ID	Drug_Name	Drug_Highest_Status	Drug_PubchemID	Molecular_Formula	Molecular_Weight	Canonical_SMILES	Activity	Binder_Type
T31989	Sphingosine kinase 2	B0DF7M	3-Hydroxy-N-[(E)-[3-[[2-(trifluoromethyl)phenyl]methoxy]phenyl]methylideneamino]benzamide	Investigative	127051495	C22H17F3N2O3	414.4	C1=CC=C(C(=C1)COC2=CC=CC(=C2)/C=N/NC(=O)C3=CC(=CC=C3)O)C(F)(F)F	IC50 ~ 100000 nM	Poor binder
T31989	Sphingosine kinase 2	B0KA1Y	[(2S)-1-[[4-[2-Methyl-3-[[(2R)-oxolan-2-yl]methyl]benzimidazol-5-yl]phenyl]methyl]pyrrolidin-2-yl]methanol	Investigative	137642521	C25H31N3O2	405.5	CC1=NC2=C(N1C[C@H]3CCCO3)C=C(C=C2)C4=CC=C(C=C4)CN5CCC[C@H]5CO	IC50 ~ 100000 nM	Poor binder
T31989	Sphingosine kinase 2	B0O5ME	N-[(E)-[3-[(3-Cyanophenyl)methoxy]phenyl]methylideneamino]-3,4,5-trihydroxybenzamide	Investigative	127052117	C22H17N3O5	403.4	C1=CC(=CC(=C1)C#N)COC2=CC=CC(=C2)/C=N/NC(=O)C3=CC(=C(C(=C3)O)O)O	IC50 ~ 100000 nM	Poor binder
T31989	Sphingosine kinase 2	B1Y4KV	3-Hydroxy-N-[(E)-[3-[(3-methoxyphenyl)methoxy]phenyl]methylideneamino]benzamide	Investigative	127052730	C22H20N2O4	376.4	COC1=CC=CC(=C1)COC2=CC=CC(=C2)/C=N/NC(=O)C3=CC(=CC=C3)O	IC50 ~ 100000 nM	Poor binder
T31989	Sphingosine kinase 2	B3MZE7	3-Hydroxy-N-[(E)-[4-[(3-methoxyphenyl)methoxy]phenyl]methylideneamino]benzamide	Investigative	127052734	C22H20N2O4	376.4	COC1=CC=CC(=C1)COC2=CC=C(C=C2)/C=N/NC(=O)C3=CC(=CC=C3)O	IC50 ~ 100000 nM	Poor binder
T31989	Sphingosine kinase 2	B3ZX6P	N-[(E)-[3-[(2-Fluorophenyl)methoxy]phenyl]methylideneamino]-3,4,5-trihydroxybenzamide	Investigative	127052719	C21H17FN2O5	396.4	C1=CC=C(C(=C1)COC2=CC=CC(=C2)/C=N/NC(=O)C3=CC(=C(C(=C3)O)O)O)F	IC50 = 98900 nM	Poor binder
T31989	Sphingosine kinase 2	B45KLX	N-[(E)-[3-[(4-Chlorophenyl)methoxy]phenyl]methylideneamino]-3,4,5-trihydroxybenzamide	Investigative	127053009	C21H17ClN2O5	412.8	C1=CC(=CC(=C1)OCC2=CC=C(C=C2)Cl)/C=N/NC(=O)C3=CC(=C(C(=C3)O)O)O	IC50 = 61200 nM	Poor binder
T31989	Sphingosine kinase 2	B4G1LH	[(2S)-1-[[4-[2-Methyl-3-[[(2S)-oxolan-2-yl]methyl]benzimidazol-5-yl]phenyl]methyl]pyrrolidin-2-yl]methanol	Investigative	137636078	C25H31N3O2	405.5	CC1=NC2=C(N1C[C@@H]3CCCO3)C=C(C=C2)C4=CC=C(C=C4)CN5CCC[C@H]5CO	IC50 ~ 100000 nM	Poor binder
T31989	Sphingosine kinase 2	B6E7IQ	[(2R)-1-[[4-[2-Methyl-3-[[(2S)-oxolan-2-yl]methyl]benzimidazol-5-yl]phenyl]methyl]pyrrolidin-2-yl]methanol	Investigative	137631941	C25H31N3O2	405.5	CC1=NC2=C(N1C[C@@H]3CCCO3)C=C(C=C2)C4=CC=C(C=C4)CN5CCC[C@@H]5CO	IC50 ~ 100000 nM	Poor binder
T31989	Sphingosine kinase 2	B6KT5Z	3,5-Dihydroxy-N-[(E)-[4-[[2-(trifluoromethyl)phenyl]methoxy]phenyl]methylideneamino]benzamide	Investigative	127051496	C22H17F3N2O4	430.4	C1=CC=C(C(=C1)COC2=CC=C(C=C2)/C=N/NC(=O)C3=CC(=CC(=C3)O)O)C(F)(F)F	IC50 ~ 100000 nM	Poor binder
T31989	Sphingosine kinase 2	B6YOW7	3-{[4-(2-Hydroxyethyl)phenyl]amino}-1-(4-propoxyphenyl)pyrrolidine-2,5-dione	Investigative	2936770	C21H24N2O4	368.4	CCCOC1=CC=C(C=C1)N2C(=O)CC(C2=O)NC3=CC=C(C=C3)CCO	IC50 = 62600 nM	Poor binder
T31989	Sphingosine kinase 2	B7Q9GK	(E,2R,3S)-5-(4-Butylphenyl)-2-(methylamino)pent-4-ene-1,3-diol	Investigative	73353633	C16H25NO2	263.37	CCCCC1=CC=C(C=C1)/C=C/[C@@H]([C@@H](CO)NC)O	Ki ~ 100000 nM	Poor binder
T31989	Sphingosine kinase 2	B90WAB	3,5-Dihydroxy-N-[(E)-[3-[[2-(trifluoromethyl)phenyl]methoxy]phenyl]methylideneamino]benzamide	Investigative	127051493	C22H17F3N2O4	430.4	C1=CC=C(C(=C1)COC2=CC=CC(=C2)/C=N/NC(=O)C3=CC(=CC(=C3)O)O)C(F)(F)F	IC50 ~ 100000 nM	Poor binder
T31989	Sphingosine kinase 2	BAL20C	3,4,5-Trihydroxy-N-[(E)-[4-[(4-methoxyphenyl)methoxy]phenyl]methylideneamino]benzamide	Investigative	127049336	C22H20N2O6	408.4	COC1=CC=C(C=C1)COC2=CC=C(C=C2)/C=N/NC(=O)C3=CC(=C(C(=C3)O)O)O	IC50 ~ 100000 nM	Poor binder
T31989	Sphingosine kinase 2	BAP21V	N-[(E)-[3-[(4-Tert-butylphenyl)methoxy]phenyl]methylideneamino]-3,4,5-trihydroxybenzamide	Investigative	127053010	C25H26N2O5	434.5	CC(C)(C)C1=CC=C(C=C1)COC2=CC=CC(=C2)/C=N/NC(=O)C3=CC(=C(C(=C3)O)O)O	IC50 = 62170 nM	Poor binder
T31989	Sphingosine kinase 2	BD09HC	N-[(E)-[3-[(2-Chlorophenyl)methoxy]phenyl]methylideneamino]-3,4,5-trihydroxybenzamide	Investigative	127053007	C21H17ClN2O5	412.8	C1=CC=C(C(=C1)COC2=CC=CC(=C2)/C=N/NC(=O)C3=CC(=C(C(=C3)O)O)O)Cl	IC50 = 58790 nM	Poor binder
T31989	Sphingosine kinase 2	BFIR67	4-Hydroxy-N-[(E)-[3-[[2-(trifluoromethyl)phenyl]methoxy]phenyl]methylideneamino]benzamide	Investigative	127050865	C22H17F3N2O3	414.4	C1=CC=C(C(=C1)COC2=CC=CC(=C2)/C=N/NC(=O)C3=CC=C(C=C3)O)C(F)(F)F	IC50 ~ 100000 nM	Poor binder
T31989	Sphingosine kinase 2	BH5YK7	8-[(2R)-1-(3,5-Difluorophenyl)pyrrolidin-2-yl]-6-(morpholine-4-carbonyl)-2-morpholino-chromen-4-one	Investigative	66557964	C28H29F2N3O5	525.5	C1C[C@@H](N(C1)C2=CC(=CC(=C2)F)F)C3=CC(=CC4=C3OC(=CC4=O)N5CCOCC5)C(=O)N6CCOCC6	IC50 ~ 50000 nM	Poor binder
T31989	Sphingosine kinase 2	BIZG91	3,4,5-Trihydroxy-N-[(E)-[3-[[3-(trifluoromethyl)phenyl]methoxy]phenyl]methylideneamino]benzamide	Investigative	127049002	C22H17F3N2O5	446.4	C1=CC(=CC(=C1)C(F)(F)F)COC2=CC=CC(=C2)/C=N/NC(=O)C3=CC(=C(C(=C3)O)O)O	IC50 ~ 100000 nM	Poor binder
T31989	Sphingosine kinase 2	BJA85N	N-[(E)-[3-[(3-Fluorophenyl)methoxy]phenyl]methylideneamino]-3,4,5-trihydroxybenzamide	Investigative	127052720	C21H17FN2O5	396.4	C1=CC(=CC(=C1)F)COC2=CC=CC(=C2)/C=N/NC(=O)C3=CC(=C(C(=C3)O)O)O	IC50 ~ 100000 nM	Poor binder
T31989	Sphingosine kinase 2	BJT15I	4-Hydroxy-N-[(E)-[4-[[2-(trifluoromethyl)phenyl]methoxy]phenyl]methylideneamino]benzamide	Investigative	127050290	C22H17F3N2O3	414.4	C1=CC=C(C(=C1)COC2=CC=C(C=C2)/C=N/NC(=O)C3=CC=C(C=C3)O)C(F)(F)F	IC50 ~ 100000 nM	Poor binder
T31989	Sphingosine kinase 2	BKCU16	3,5-Dihydroxy-N-[(E)-[3-[(3-methoxyphenyl)methoxy]phenyl]methylideneamino]benzamide	Investigative	127052728	C22H20N2O5	392.4	COC1=CC=CC(=C1)COC2=CC=CC(=C2)/C=N/NC(=O)C3=CC(=CC(=C3)O)O	IC50 ~ 100000 nM	Poor binder
T31989	Sphingosine kinase 2	BL58OE	3-Hydroxy-N-[(E)-[4-[[2-(trifluoromethyl)phenyl]methoxy]phenyl]methylideneamino]benzamide	Investigative	127049994	C22H17F3N2O3	414.4	C1=CC=C(C(=C1)COC2=CC=C(C=C2)/C=N/NC(=O)C3=CC(=CC=C3)O)C(F)(F)F	IC50 ~ 100000 nM	Poor binder
T31989	Sphingosine kinase 2	BLI6J3	3,4,5-Trihydroxy-N-[(E)-[3-[(4-methoxyphenyl)methoxy]phenyl]methylideneamino]benzamide	Investigative	127052121	C22H20N2O6	408.4	COC1=CC=C(C=C1)COC2=CC=CC(=C2)/C=N/NC(=O)C3=CC(=C(C(=C3)O)O)O	IC50 ~ 100000 nM	Poor binder
T31989	Sphingosine kinase 2	BLPG87	3,4,5-Trihydroxy-N-[(E)-[3-[(2-methylphenyl)methoxy]phenyl]methylideneamino]benzamide	Investigative	127048670	C22H20N2O5	392.4	CC1=CC=CC=C1COC2=CC=CC(=C2)/C=N/NC(=O)C3=CC(=C(C(=C3)O)O)O	IC50 = 81170 nM	Poor binder
T31989	Sphingosine kinase 2	BMZ9X1	N-[(E)-[3-[(2-Cyanophenyl)methoxy]phenyl]methylideneamino]-3,4,5-trihydroxybenzamide	Investigative	127051810	C22H17N3O5	403.4	C1=CC=C(C(=C1)COC2=CC=CC(=C2)/C=N/NC(=O)C3=CC(=C(C(=C3)O)O)O)C#N	IC50 = 68550 nM	Poor binder
T31989	Sphingosine kinase 2	BN1KS2	N-[(E)-[3-[(4-Fluorophenyl)methoxy]phenyl]methylideneamino]-3,4,5-trihydroxybenzamide	Investigative	127052721	C21H17FN2O5	396.4	C1=CC(=CC(=C1)OCC2=CC=C(C=C2)F)/C=N/NC(=O)C3=CC(=C(C(=C3)O)O)O	IC50 ~ 100000 nM	Poor binder
T31989	Sphingosine kinase 2	BP34GE	3,4,5-Trihydroxy-N-[(E)-[3-[(3-methylphenyl)methoxy]phenyl]methylideneamino]benzamide	Investigative	127048671	C22H20N2O5	392.4	CC1=CC(=CC=C1)COC2=CC=CC(=C2)/C=N/NC(=O)C3=CC(=C(C(=C3)O)O)O	IC50 = 78690 nM	Poor binder
T31989	Sphingosine kinase 2	BQ35HV	N-(3-Chloro-1,4-dioxonaphthalen-2-yl)-N-cyclohexylacetamide	Investigative	282594	C18H18ClNO3	331.8	CC(=O)N(C1CCCCC1)C2=C(C(=O)C3=CC=CC=C3C2=O)Cl	IC50 ~ 100000 nM	Poor binder
T31989	Sphingosine kinase 2	BQ43KI	3,5-Dihydroxy-N-[(E)-[4-[(3-methoxyphenyl)methoxy]phenyl]methylideneamino]benzamide	Investigative	127052732	C22H20N2O5	392.4	COC1=CC=CC(=C1)COC2=CC=C(C=C2)/C=N/NC(=O)C3=CC(=CC(=C3)O)O	IC50 ~ 100000 nM	Poor binder
T31989	Sphingosine kinase 2	BQGL30	4-Hydroxy-N-[(E)-[4-[(3-methoxyphenyl)methoxy]phenyl]methylideneamino]benzamide	Investigative	127051492	C22H20N2O4	376.4	COC1=CC=CC(=C1)COC2=CC=C(C=C2)/C=N/NC(=O)C3=CC=C(C=C3)O	IC50 ~ 100000 nM	Poor binder
T31989	Sphingosine kinase 2	BS1N0U	N'-{(E)-[3-(Benzyloxy)phenyl]methylidene}-1H-benzimidazole-6-carbohydrazide	Investigative	9660619	C22H18N4O2	370.4	C1=CC=C(C=C1)COC2=CC=CC(=C2)/C=N/NC(=O)C3=CC4=C(C=C3)N=CN4	IC50 ~ 100000 nM	Poor binder
T31989	Sphingosine kinase 2	BWN9Y5	3,4,5-Trihydroxy-N-[(E)-[3-[(4-methylphenyl)methoxy]phenyl]methylideneamino]benzamide	Investigative	127048672	C22H20N2O5	392.4	CC1=CC=C(C=C1)COC2=CC=CC(=C2)/C=N/NC(=O)C3=CC(=C(C(=C3)O)O)O	IC50 = 65380 nM	Poor binder
T31989	Sphingosine kinase 2	BXF3Y9	4-Hydroxy-N-[(E)-[3-[(3-methoxyphenyl)methoxy]phenyl]methylideneamino]benzamide	Investigative	127052731	C22H20N2O4	376.4	COC1=CC=CC(=C1)COC2=CC=CC(=C2)/C=N/NC(=O)C3=CC=C(C=C3)O	IC50 ~ 100000 nM	Poor binder
T31989	Sphingosine kinase 2	BZFL16	N-[(E)-[3-[(3-Chlorophenyl)methoxy]phenyl]methylideneamino]-3,4,5-trihydroxybenzamide	Investigative	127053008	C21H17ClN2O5	412.8	C1=CC(=CC(=C1)Cl)COC2=CC=CC(=C2)/C=N/NC(=O)C3=CC(=C(C(=C3)O)O)O	IC50 = 67370 nM	Poor binder
T31989	Sphingosine kinase 2	D00YNY	VPC-94075	Investigative	753704	C15H11ClN2OS	302.8	C1=CC(=CC=C1C2=CSC(=N2)NC3=CC=C(C=C3)O)Cl	Ki = 50000 nM	Poor binder
T31989	Sphingosine kinase 2	D05SLY	SK1-I	Investigative	44815217	C17H27NO2	277.4	CCCCCC1=CC=C(C=C1)/C=C/[C@@H]([C@@H](CO)NC)O	Ki ~ 100000 nM	Poor binder