TTD_Target_ID	Target_Name	TTD_Drug_ID	Drug_Name	Drug_Highest_Status	Drug_PubchemID	Molecular_Formula	Molecular_Weight	Canonical_SMILES	Activity	Binder_Type
T32880	HIF-prolyl hydroxylase 2	D06VNK	Succinic acid	Approved	1110	C4H6O4	118.09	C(CC(=O)O)C(=O)O	IC50 = 85300 nM	Poor binder
T32880	HIF-prolyl hydroxylase 2	D09NCT	PMID25468267-Compound-46	Patented	53392492	C27H29N3O6	491.5	C1=CC=C2C(=C1)C=CC=C2NC(=O)OCC3=CC=C(C=C3)CNCCCCN(C(=O)/C=C/C(=O)O)O	IC50 = 83000 nM	Poor binder
T32880	HIF-prolyl hydroxylase 2	B0G2IW	3-[(7-Benzyl-4-hydroxy-8-oxo-1-pyridin-3-yl-7,8-dihydro-[2,7]naphthyridine-3-carbonyl)-amino]-propionic acid	Investigative	60152379	C24H20N4O5	444.4	C1=CC=C(C=C1)CN2C=CC3=C(C2=O)C(=NC(=C3O)C(=O)NCCC(=O)O)C4=CN=CC=C4	IC50 = 200000 nM	Poor binder
T32880	HIF-prolyl hydroxylase 2	B0HFM5	1-[[(1-Cyano-7-cyclohexylsulfonyl-4-hydroxyisoquinoline-3-carbonyl)amino]methyl]cyclobutane-1-carboxylic acid	Investigative	71736596	C23H25N3O6S	471.5	C1CCC(CC1)S(=O)(=O)C2=CC3=C(C=C2)C(=C(N=C3C#N)C(=O)NCC4(CCC4)C(=O)O)O	IC50 = 200000 nM	Poor binder
T32880	HIF-prolyl hydroxylase 2	B0ZX5V	N-[(1-Chloro-4-hydroxyisoquinolin-3-YL)carbonyl]glycine	Investigative	6914666	C12H9ClN2O4	280.66	C1=CC=C2C(=C1)C(=C(N=C2Cl)C(=O)NCC(=O)O)O	EC50 = 79000 nM	Poor binder
T32880	HIF-prolyl hydroxylase 2	B17HYF	5-[(4-Hydroxy-7-phenylsulfanylisoquinoline-3-carbonyl)amino]pentanoic acid	Investigative	71736103	C21H20N2O4S	396.5	C1=CC=C(C=C1)SC2=CC3=CN=C(C(=C3C=C2)O)C(=O)NCCCCC(=O)O	IC50 = 86620 nM	Poor binder
T32880	HIF-prolyl hydroxylase 2	B19ICF	7-Benzyl-1-cyano-4-hydroxy-8-oxo-N-(pyridazin-4-ylmethyl)-2,7-naphthyridine-3-carboxamide	Investigative	60150992	C22H16N6O3	412.4	C1=CC=C(C=C1)CN2C=CC3=C(C2=O)C(=NC(=C3O)C(=O)NCC4=CN=NC=C4)C#N	IC50 = 177000 nM	Poor binder
T32880	HIF-prolyl hydroxylase 2	B1HXM0	1'-(Pyrimidin-2-ylmethyl)-1-quinolin-3-ylspiro[indole-3,4'-piperidine]-2-one	Investigative	57385738	C26H23N5O	421.5	C1CN(CCC12C3=CC=CC=C3N(C2=O)C4=CC5=CC=CC=C5N=C4)CC6=NC=CC=N6	IC50 ~ 50000 nM	Poor binder
T32880	HIF-prolyl hydroxylase 2	B1JQ8X	2-[(6-Fluoro-1H-benzimidazole-2-carbonyl)amino]acetic acid	Investigative	53319897	C10H8FN3O3	237.19	C1=CC2=C(C=C1F)NC(=N2)C(=O)NCC(=O)O	IC50 ~ 100000 nM	Poor binder
T32880	HIF-prolyl hydroxylase 2	B1KL3U	(2S)-2-Hydroxy-3-[[4-hydroxy-7-(phenylcarbamoylamino)isoquinoline-3-carbonyl]amino]propanoic acid	Investigative	71736258	C20H18N4O6	410.4	C1=CC=C(C=C1)NC(=O)NC2=CC3=CN=C(C(=C3C=C2)O)C(=O)NC[C@@H](C(=O)O)O	IC50 = 51440 nM	Poor binder
T32880	HIF-prolyl hydroxylase 2	B1O4LV	3-[(1-Benzyl-5-hydroxy-2-oxo-3-phenyl-8-pyrazin-2-yl-1,2-dihydro-[1,7]naphthyridine-6-carbonyl)-amino]-propionic acid	Investigative	135981244	C29H23N5O5	521.5	C1=CC=C(C=C1)CN2C3=C(C=C(C2=O)C4=CC=CC=C4)C(=C(N=C3C5=NC=CN=C5)C(=O)NCCC(=O)O)O	IC50 = 92600 nM	Poor binder
T32880	HIF-prolyl hydroxylase 2	B1XOP0	4-[8-(Dimethylamino)octyl-hydroxyamino]-4-oxobutanoic acid;hydrochloride	Investigative	46899762	C14H29ClN2O4	324.84	CN(C)CCCCCCCCN(C(=O)CCC(=O)O)O.Cl	IC50 ~ 100000 nM	Poor binder
T32880	HIF-prolyl hydroxylase 2	B1YKW9	2-(2-Ethoxy-2-oxoacetamido)acetic acid	Investigative	45482712	C6H9NO5	175.14	CCOC(=O)C(=O)NCC(=O)O	IC50 = 78000 nM	Poor binder
T32880	HIF-prolyl hydroxylase 2	B1ZP3W	2-[1-[(1-Cyano-4-hydroxy-7-phenoxyisoquinoline-3-carbonyl)amino]cyclohexyl]acetic acid	Investigative	89813070	C25H23N3O5	445.5	C1CCC(CC1)(CC(=O)O)NC(=O)C2=C(C3=C(C=C(C=C3)OC4=CC=CC=C4)C(=N2)C#N)O	IC50 = 56310 nM	Poor binder
T32880	HIF-prolyl hydroxylase 2	B23LOJ	trans-4-[(1-Cyano-4-hydroxy-7-phenoxy-isoquinoline-3-carbonyl)-amino]-cyclohexanecarboxylic acid	Investigative	117844068	C24H21N3O5	431.4	C1CC(CCC1C(=O)O)NC(=O)C2=C(C3=C(C=C(C=C3)OC4=CC=CC=C4)C(=N2)C#N)O	IC50 = 93290 nM	Poor binder
T32880	HIF-prolyl hydroxylase 2	B23NIM	3-{[1-Benzyl-5-(5-fluoro-pyridin-3-yl)-8-hydroxy-2-oxo-1,2-dihydro-[1,6]naphthyridine-7-carbonyl]-amino}-propionic acid	Investigative	68297562	C24H19FN4O5	462.4	C1=CC=C(C=C1)CN2C(=O)C=CC3=C2C(=C(N=C3C4=CC(=CN=C4)F)C(=O)NCCC(=O)O)O	IC50 = 51000 nM	Poor binder
T32880	HIF-prolyl hydroxylase 2	B23NMP	3-[(1-Benzyl-8-cyano-5-hydroxy-2-oxo-3-phenyl-1,2-dihydro-[1,7]naphthyridine-6-carbonyl)-amino]-2,2-dimethyl-propionic acid	Investigative	60152634	C28H24N4O5	496.5	CC(C)(CNC(=O)C1=C(C2=C(C(=N1)C#N)N(C(=O)C(=C2)C3=CC=CC=C3)CC4=CC=CC=C4)O)C(=O)O	IC50 = 149000 nM	Poor binder
T32880	HIF-prolyl hydroxylase 2	B2D8ZH	5-[[4-Hydroxy-7-[(4-methoxyphenyl)methylamino]isoquinoline-3-carbonyl]amino]pentanoic acid	Investigative	89812999	C23H25N3O5	423.5	COC1=CC=C(C=C1)CNC2=CC3=CN=C(C(=C3C=C2)O)C(=O)NCCCCC(=O)O	IC50 = 158180 nM	Poor binder
T32880	HIF-prolyl hydroxylase 2	B2HG1B	3-{[1-Benzyl-5-hydroxy-8-(6-methoxy-pyridin-3-yl)-2-oxo-3-phenyl-1,2-dihydro-[1,7]naphthyridine-6-carbonyl]-amino}-propionic acid	Investigative	68297432	C31H26N4O6	550.6	COC1=NC=C(C=C1)C2=NC(=C(C3=C2N(C(=O)C(=C3)C4=CC=CC=C4)CC5=CC=CC=C5)O)C(=O)NCCC(=O)O	IC50 = 57000 nM	Poor binder
T32880	HIF-prolyl hydroxylase 2	B2KJ4H	(R)-2-[(1-Benzyl-5-hydroxy-2-oxo-3-phenyl-1,2-dihydro-[1,7]naphthyridine-6-carbonyl)-amino]-3-phenyl-propionic acid	Investigative	68297757	C31H25N3O5	519.5	C1=CC=C(C=C1)C[C@H](C(=O)O)NC(=O)C2=NC=C3C(=C2O)C=C(C(=O)N3CC4=CC=CC=C4)C5=CC=CC=C5	IC50 = 102700 nM	Poor binder
T32880	HIF-prolyl hydroxylase 2	B2NUQ4	3-[(1-Cyclohexylmethyl-5-hydroxy-2-oxo-3-phenyl-8-pyridin-4-yl-1,2-dihydro-[1,7]naphthyridine-6-carbonyl)-amino]-propionic acid	Investigative	135981265	C30H30N4O5	526.6	C1CCC(CC1)CN2C3=C(C=C(C2=O)C4=CC=CC=C4)C(=C(N=C3C5=CC=NC=C5)C(=O)NCCC(=O)O)O	IC50 = 200000 nM	Poor binder
T32880	HIF-prolyl hydroxylase 2	B2RG4B	3-[(4-Hydroxy-7-phenoxyisoquinoline-3-carbonyl)amino]-3-methylbutanoic acid	Investigative	89812858	C21H20N2O5	380.4	CC(C)(CC(=O)O)NC(=O)C1=NC=C2C=C(C=CC2=C1O)OC3=CC=CC=C3	IC50 = 191920 nM	Poor binder
T32880	HIF-prolyl hydroxylase 2	B30YDV	3-[(1-Benzyl-5-hydroxy-2-oxo-3-phenyl-1,2-dihydro-[1,7]naphthyridine-6-carbonyl)-amino]-2,2-dimethyl-propionic acid	Investigative	68297186	C27H25N3O5	471.5	CC(C)(CNC(=O)C1=NC=C2C(=C1O)C=C(C(=O)N2CC3=CC=CC=C3)C4=CC=CC=C4)C(=O)O	IC50 = 91000 nM	Poor binder
T32880	HIF-prolyl hydroxylase 2	B35QRL	4-Thioxo-L-proline	Investigative	18632368	C5H7NO2S	145.18	C1[C@H](NCC1=S)C(=O)O	IC50 = 69700 nM	Poor binder
T32880	HIF-prolyl hydroxylase 2	B3KGX2	(2S)-2-Amino-3-[(1-cyano-4-hydroxy-7-phenoxyisoquinoline-3-carbonyl)amino]propanoic acid	Investigative	71737071	C20H16N4O5	392.4	C1=CC=C(C=C1)OC2=CC3=C(C=C2)C(=C(N=C3C#N)C(=O)NC[C@@H](C(=O)O)N)O	IC50 = 51920 nM	Poor binder
T32880	HIF-prolyl hydroxylase 2	B41EXU	3-[(4-Hydroxy-7-phenylisoquinoline-3-carbonyl)amino]-2,2-dimethylpropanoic acid	Investigative	71736746	C21H20N2O4	364.4	CC(C)(CNC(=O)C1=NC=C2C=C(C=CC2=C1O)C3=CC=CC=C3)C(=O)O	IC50 = 179680 nM	Poor binder
T32880	HIF-prolyl hydroxylase 2	B47XBP	1-Benzyl-5-hydroxy-N-[2-[methyl(methylsulfonyl)amino]ethyl]-2-oxo-3-phenyl-1,7-naphthyridine-6-carboxamide	Investigative	60151402	C26H26N4O5S	506.6	CN(CCNC(=O)C1=NC=C2C(=C1O)C=C(C(=O)N2CC3=CC=CC=C3)C4=CC=CC=C4)S(=O)(=O)C	IC50 = 200000 nM	Poor binder
T32880	HIF-prolyl hydroxylase 2	B4DUX9	3-[(4-Hydroxy-1-methyl-7-phenoxyisoquinoline-3-carbonyl)amino]propanoic acid	Investigative	89812855	C20H18N2O5	366.4	CC1=C2C=C(C=CC2=C(C(=N1)C(=O)NCCC(=O)O)O)OC3=CC=CC=C3	IC50 = 200000 nM	Poor binder
T32880	HIF-prolyl hydroxylase 2	B4XSL8	2-[[5-(3-Chlorophenyl)pyridine-2-carbonyl]amino]acetic acid	Investigative	44419132	C14H11ClN2O3	290.7	C1=CC(=CC(=C1)Cl)C2=CN=C(C=C2)C(=O)NCC(=O)O	IC50 ~ 100000 nM	Poor binder
T32880	HIF-prolyl hydroxylase 2	B5VFX9	3-[(1-Benzyl-8-hydroxy-2-oxo-1,2-dihydro-[1,6]naphthyridine-7-carbonyl)-amino]-propionic acid	Investigative	60151129	C19H17N3O5	367.4	C1=CC=C(C=C1)CN2C(=O)C=CC3=CN=C(C(=C32)O)C(=O)NCCC(=O)O	IC50 = 167000 nM	Poor binder
T32880	HIF-prolyl hydroxylase 2	B62GNT	4-(Hydroxyamino)-4-oxobutanoic acid	Investigative	252439	C4H7NO4	133.1	C(CC(=O)O)C(=O)NO	IC50 = 94000 nM	Poor binder
T32880	HIF-prolyl hydroxylase 2	B63IHS	(3R)-3-[(1-Cyano-4-hydroxy-7-phenoxyisoquinoline-3-carbonyl)amino]-3-phenylpropanoic acid	Investigative	71737525	C26H19N3O5	453.4	C1=CC=C(C=C1)[C@@H](CC(=O)O)NC(=O)C2=C(C3=C(C=C(C=C3)OC4=CC=CC=C4)C(=N2)C#N)O	IC50 = 50150 nM	Poor binder
T32880	HIF-prolyl hydroxylase 2	B69BDC	3-[(1-Benzyl-5-hydroxy-2-oxo-3-phenyl-8-pyridazin-3-yl-1,2-dihydro-[1,7]naphthyridine-6-carbonyl)-amino]-propionic acid	Investigative	135981268	C29H23N5O5	521.5	C1=CC=C(C=C1)CN2C3=C(C=C(C2=O)C4=CC=CC=C4)C(=C(N=C3C5=NN=CC=C5)C(=O)NCCC(=O)O)O	IC50 = 200000 nM	Poor binder
T32880	HIF-prolyl hydroxylase 2	B6ELI0	5-[(1-Benzyl-5-hydroxy-2-oxo-3-phenyl-8-pyridin-3-yl-1,2-dihydro-[1,7]naphthyridine-6-carbonyl)-amino]-pentanoic acid	Investigative	68297545	C32H28N4O5	548.6	C1=CC=C(C=C1)CN2C3=C(C=C(C2=O)C4=CC=CC=C4)C(=C(N=C3C5=CN=CC=C5)C(=O)NCCCCC(=O)O)O	IC50 = 200000 nM	Poor binder
T32880	HIF-prolyl hydroxylase 2	B6K8NX	1'-(1,2,4-Oxadiazol-3-ylmethyl)-1-quinolin-3-ylspiro[indole-3,4'-piperidine]-2-one	Investigative	57385737	C24H21N5O2	411.5	C1CN(CCC12C3=CC=CC=C3N(C2=O)C4=CC5=CC=CC=C5N=C4)CC6=NOC=N6	IC50 ~ 50000 nM	Poor binder
T32880	HIF-prolyl hydroxylase 2	B6MT2O	3-[9-(Dimethylamino)nonanoyl-hydroxyamino]propanoic acid	Investigative	46899607	C14H28N2O4	288.38	CN(C)CCCCCCCCC(=O)N(CCC(=O)O)O	IC50 ~ 100000 nM	Poor binder
T32880	HIF-prolyl hydroxylase 2	B6S7GU	1-Benzyl-5-hydroxy-8-methyl-2-oxo-3-phenyl-1,2-dihydro-[1,7]naphthyridine-6-carboxylic acid [2-(methanesulfonyl-methyl-amino)-ethyl]-amide	Investigative	86714135	C27H28N4O5S	520.6	CC1=C2C(=C(C(=N1)C(=O)NCCN(C)S(=O)(=O)C)O)C=C(C(=O)N2CC3=CC=CC=C3)C4=CC=CC=C4	IC50 = 200000 nM	Poor binder
T32880	HIF-prolyl hydroxylase 2	B72GPH	5-[[1-Cyano-6-(2,6-dimethylphenoxy)-4-hydroxyisoquinoline-3-carbonyl]amino]pentanoic acid	Investigative	71736594	C24H23N3O5	433.5	CC1=C(C(=CC=C1)C)OC2=CC3=C(C=C2)C(=NC(=C3O)C(=O)NCCCCC(=O)O)C#N	IC50 = 111990 nM	Poor binder
T32880	HIF-prolyl hydroxylase 2	B76MYT	5-[[1-(5-Fluoropyridin-3-yl)-4-hydroxy-7-phenoxyisoquinoline-3-carbonyl]amino]pentanoic acid	Investigative	89813079	C26H22FN3O5	475.5	C1=CC=C(C=C1)OC2=CC3=C(C=C2)C(=C(N=C3C4=CC(=CN=C4)F)C(=O)NCCCCC(=O)O)O	IC50 = 76960 nM	Poor binder
T32880	HIF-prolyl hydroxylase 2	B79HTC	3-[[1-Benzyl-5-hydroxy-2-oxo-3-phenyl-8-[6-(trifluoromethyl)pyridin-3-yl]-1,7-naphthyridine-6-carbonyl]amino]propanoic acid	Investigative	68297465	C31H23F3N4O5	588.5	C1=CC=C(C=C1)CN2C3=C(C=C(C2=O)C4=CC=CC=C4)C(=C(N=C3C5=CN=C(C=C5)C(F)(F)F)C(=O)NCCC(=O)O)O	IC50 = 106600 nM	Poor binder
T32880	HIF-prolyl hydroxylase 2	B7ISC2	4-[(4-Hydroxy-6-phenoxyisoquinoline-3-carbonyl)amino]butanoic acid	Investigative	89812909	C20H18N2O5	366.4	C1=CC=C(C=C1)OC2=CC3=C(C(=NC=C3C=C2)C(=O)NCCCC(=O)O)O	IC50 = 200000 nM	Poor binder
T32880	HIF-prolyl hydroxylase 2	B7PO5F	2-(3-Hydroxy-2-pyridinyl)-4-thiazoleacetic Acid	Investigative	135737442	C10H8N2O3S	236.25	C1=CC(=C(N=C1)C2=NC(=CS2)CC(=O)O)O	IC50 = 195000 nM	Poor binder
T32880	HIF-prolyl hydroxylase 2	B7YU9G	Glycine, N-(2-methoxy-2-oxoacetyl)-	Investigative	14991438	C5H7NO5	161.11	COC(=O)C(=O)NCC(=O)O	IC50 = 95000 nM	Poor binder
T32880	HIF-prolyl hydroxylase 2	B8AEK7	1'-(1-Methylimidazole-2-carbonyl)-1-quinolin-3-ylspiro[indole-3,4'-piperidine]-2-one	Investigative	57386010	C26H23N5O2	437.5	CN1C=CN=C1C(=O)N2CCC3(CC2)C4=CC=CC=C4N(C3=O)C5=CC6=CC=CC=C6N=C5	IC50 ~ 50000 nM	Poor binder
T32880	HIF-prolyl hydroxylase 2	B8CVR3	3-[(1-Benzyl-5-hydroxy-2-oxo-3-phenyl-8-thiazol-4-yl-1,2-dihydro-[1,7]naphthyridine-6-carbonyl)-amino]-propionic acid	Investigative	60152377	C28H22N4O5S	526.6	C1=CC=C(C=C1)CN2C3=C(C=C(C2=O)C4=CC=CC=C4)C(=C(N=C3C5=CSC=N5)C(=O)NCCC(=O)O)O	IC50 = 200000 nM	Poor binder
T32880	HIF-prolyl hydroxylase 2	B8SH4W	1-Benzyl-5-hydroxy-N-[2-(methanesulfonamido)ethyl]-2-oxo-3-phenyl-1,7-naphthyridine-6-carboxamide	Investigative	86714133	C25H24N4O5S	492.5	CS(=O)(=O)NCCNC(=O)C1=NC=C2C(=C1O)C=C(C(=O)N2CC3=CC=CC=C3)C4=CC=CC=C4	IC50 = 64800 nM	Poor binder
T32880	HIF-prolyl hydroxylase 2	B92ONL	2-Cyclopropyl-3-[(4-hydroxy-7-phenoxyisoquinoline-3-carbonyl)amino]propanoic acid	Investigative	71736741	C22H20N2O5	392.4	C1CC1C(CNC(=O)C2=NC=C3C=C(C=CC3=C2O)OC4=CC=CC=C4)C(=O)O	IC50 = 99980 nM	Poor binder
T32880	HIF-prolyl hydroxylase 2	B95CZK	3-[(5-Hydroxy-1-methyl-2-oxo-3-phenyl-8-pyridin-3-yl-1,2-dihydro-[1,7]naphthyridine-6-carbonyl)-amino]-propionic acid	Investigative	60151963	C24H20N4O5	444.4	CN1C2=C(C=C(C1=O)C3=CC=CC=C3)C(=C(N=C2C4=CN=CC=C4)C(=O)NCCC(=O)O)O	IC50 = 69800 nM	Poor binder
T32880	HIF-prolyl hydroxylase 2	B96KDG	3-({9-[Butyl(Methyl)]Amino}Nonanoyl(Hydroxy)Amino)Propanoicacid HCl	Investigative	46899764	C17H35ClN2O4	366.9	CCCCN(C)CCCCCCCCC(=O)N(CCC(=O)O)O.Cl	IC50 ~ 100000 nM	Poor binder
T32880	HIF-prolyl hydroxylase 2	B9AEH2	1-Benzyl-5-hydroxy-N-[2-[methyl(methylsulfonyl)amino]ethyl]-2-oxo-3,8-diphenyl-1,7-naphthyridine-6-carboxamide	Investigative	60151681	C32H30N4O5S	582.7	CN(CCNC(=O)C1=C(C2=C(C(=N1)C3=CC=CC=C3)N(C(=O)C(=C2)C4=CC=CC=C4)CC5=CC=CC=C5)O)S(=O)(=O)C	IC50 = 200000 nM	Poor binder
T32880	HIF-prolyl hydroxylase 2	B9DLP3	Cn1nc(cc1-c1nc(C(=O)NCC(C)(C)C(O)=O)c(O)c2ccc(Oc3ccccc3)cc12)C(F)(F)F	Investigative	136218056	C26H23F3N4O5	528.5	CC(C)(CNC(=O)C1=C(C2=C(C=C(C=C2)OC3=CC=CC=C3)C(=N1)C4=CC(=NN4C)C(F)(F)F)O)C(=O)O	IC50 = 111450 nM	Poor binder
T32880	HIF-prolyl hydroxylase 2	B9O7LG	1'-(1-Pyridin-2-ylethyl)-1-quinolin-3-ylspiro[indole-3,4'-piperidine]-2-one	Investigative	57386263	C28H26N4O	434.5	CC(C1=CC=CC=N1)N2CCC3(CC2)C4=CC=CC=C4N(C3=O)C5=CC6=CC=CC=C6N=C5	IC50 ~ 50000 nM	Poor binder
T32880	HIF-prolyl hydroxylase 2	B9PNO0	4-(Isopropylamino)-4-oxobutanoic acid	Investigative	245007	C7H13NO3	159.18	CC(C)NC(=O)CCC(=O)O	IC50 ~ 100000 nM	Poor binder
T32880	HIF-prolyl hydroxylase 2	B9QNC7	(2S)-2-[[4,6-Bis(trifluoromethyl)-1H-benzimidazole-2-carbonyl]amino]propanoic acid	Investigative	53318573	C13H9F6N3O3	369.22	C[C@@H](C(=O)O)NC(=O)C1=NC2=C(C=C(C=C2N1)C(F)(F)F)C(F)(F)F	IC50 = 50118.72 nM	Poor binder
T32880	HIF-prolyl hydroxylase 2	B9RP2G	2-[[3-Hydroxy-5-(4-isocyanophenyl)pyridine-2-carbonyl]amino]acetic acid	Investigative	59513097	C15H11N3O4	297.26	[C-]#[N+]C1=CC=C(C=C1)C2=CC(=C(N=C2)C(=O)NCC(=O)O)O	IC50 = 99000 nM	Poor binder
T32880	HIF-prolyl hydroxylase 2	B9RVX4	(2S)-2-Hydroxy-4-[(4-hydroxy-7-phenoxyisoquinoline-3-carbonyl)amino]butanoic acid	Investigative	89813101	C20H18N2O6	382.4	C1=CC=C(C=C1)OC2=CC3=CN=C(C(=C3C=C2)O)C(=O)NCC[C@@H](C(=O)O)O	IC50 = 52740 nM	Poor binder
T32880	HIF-prolyl hydroxylase 2	B9VDM3	2-[[6-(3-Methylphenyl)imidazo[1,2-a]pyridine-2-carbonyl]amino]acetic acid	Investigative	44419346	C17H15N3O3	309.32	CC1=CC(=CC=C1)C2=CN3C=C(N=C3C=C2)C(=O)NCC(=O)O	IC50 ~ 100000 nM	Poor binder
T32880	HIF-prolyl hydroxylase 2	BA8E7O	4-[[(4-Hydroxy-7-phenoxyisoquinoline-3-carbonyl)amino]methyl]oxane-4-carboxylic acid	Investigative	89812867	C23H22N2O6	422.4	C1COCCC1(CNC(=O)C2=NC=C3C=C(C=CC3=C2O)OC4=CC=CC=C4)C(=O)O	IC50 = 51520 nM	Poor binder
T32880	HIF-prolyl hydroxylase 2	BB3DR2	3-[(4-Hydroxy-6-phenoxyisoquinoline-3-carbonyl)amino]propanoic acid	Investigative	71736438	C19H16N2O5	352.3	C1=CC=C(C=C1)OC2=CC3=C(C(=NC=C3C=C2)C(=O)NCCC(=O)O)O	IC50 = 200000 nM	Poor binder
T32880	HIF-prolyl hydroxylase 2	BB3XA1	5-Chloro-7-[benzoylamino(3-methyl-2-thienyl)methyl]-8-quinolinol	Investigative	122383780	C22H17ClN2O2S	408.9	CC1=C(SC=C1)C(C2=CC(=C3C=CC=NC3=C2O)Cl)NC(=O)C4=CC=CC=C4	IC50 = 96000 nM	Poor binder
T32880	HIF-prolyl hydroxylase 2	BB4IP1	5-[(7-Anilino-4-hydroxyisoquinoline-3-carbonyl)amino]pentanoic acid	Investigative	71736102	C21H21N3O4	379.4	C1=CC=C(C=C1)NC2=CC3=CN=C(C(=C3C=C2)O)C(=O)NCCCCC(=O)O	IC50 = 200000 nM	Poor binder
T32880	HIF-prolyl hydroxylase 2	BBG21Z	3-[[7-(4-Fluorophenyl)-4-hydroxyisoquinoline-3-carbonyl]amino]-2,2-dimethylpropanoic acid	Investigative	89812861	C21H19FN2O4	382.4	CC(C)(CNC(=O)C1=NC=C2C=C(C=CC2=C1O)C3=CC=C(C=C3)F)C(=O)O	IC50 = 113830 nM	Poor binder
T32880	HIF-prolyl hydroxylase 2	BBXS17	3-[(7-Benzyl-1-cyano-4-hydroxy-8-oxo-7,8-dihydro-[2,7]naphthyridine-3-carbonyl)-amino]-propionic acid	Investigative	60152770	C20H16N4O5	392.4	C1=CC=C(C=C1)CN2C=CC3=C(C2=O)C(=NC(=C3O)C(=O)NCCC(=O)O)C#N	IC50 = 95000 nM	Poor binder
T32880	HIF-prolyl hydroxylase 2	BC25AJ	5-[(4-Hydroxy-7-phenoxyisoquinoline-3-carbonyl)amino]pentanoic acid	Investigative	71735138	C21H20N2O5	380.4	C1=CC=C(C=C1)OC2=CC3=CN=C(C(=C3C=C2)O)C(=O)NCCCCC(=O)O	IC50 = 61690 nM	Poor binder
T32880	HIF-prolyl hydroxylase 2	BC3IK2	(1R)-2-[(1-Cyano-4-hydroxy-7-phenoxyisoquinoline-3-carbonyl)amino]cyclopentane-1-carboxylic acid	Investigative	117850100	C23H19N3O5	417.4	C1C[C@H](C(C1)NC(=O)C2=C(C3=C(C=C(C=C3)OC4=CC=CC=C4)C(=N2)C#N)O)C(=O)O	IC50 = 94810 nM	Poor binder
T32880	HIF-prolyl hydroxylase 2	BC41LM	(2R,3R)-3-[(1-Cyano-4-hydroxy-7-phenoxyisoquinoline-3-carbonyl)amino]-2-methylbutanoic acid	Investigative	71737229	C22H19N3O5	405.4	C[C@H]([C@@H](C)NC(=O)C1=C(C2=C(C=C(C=C2)OC3=CC=CC=C3)C(=N1)C#N)O)C(=O)O	IC50 = 64080 nM	Poor binder
T32880	HIF-prolyl hydroxylase 2	BCB9R2	3-{[1-Benzyl-5-hydroxy-8-(6-methyl-pyridin-3-yl)-2-oxo-3-phenyl-1,2-dihydro-[1,7]naphthyridine-6-carbonyl]amino}-propionic acid	Investigative	68297511	C31H26N4O5	534.6	CC1=NC=C(C=C1)C2=NC(=C(C3=C2N(C(=O)C(=C3)C4=CC=CC=C4)CC5=CC=CC=C5)O)C(=O)NCCC(=O)O	IC50 = 176500 nM	Poor binder
T32880	HIF-prolyl hydroxylase 2	BCJ4O5	4,6-Dioxoheptanoic acid	Investigative	5312	C7H10O4	158.15	CC(=O)CC(=O)CCC(=O)O	IC50 ~ 100000 nM	Poor binder
T32880	HIF-prolyl hydroxylase 2	BEB9R8	3-[(5-Hydroxy-2-oxo-1,3-diphenyl-1,2-dihydro-[1,7]naphthyridine-6-carbonyl)-amino]-propionic acid	Investigative	68297509	C24H19N3O5	429.4	C1=CC=C(C=C1)C2=CC3=C(C(=NC=C3N(C2=O)C4=CC=CC=C4)C(=O)NCCC(=O)O)O	IC50 = 56100 nM	Poor binder
T32880	HIF-prolyl hydroxylase 2	BEOV90	(2R)-2-[[4,6-Bis(trifluoromethyl)-1H-benzimidazole-2-carbonyl]amino]propanoic acid	Investigative	53319898	C13H9F6N3O3	369.22	C[C@H](C(=O)O)NC(=O)C1=NC2=C(C=C(C=C2N1)C(F)(F)F)C(F)(F)F	IC50 = 79432.82 nM	Poor binder
T32880	HIF-prolyl hydroxylase 2	BFG9L3	1-Phenyl-1'-pyridin-2-ylsulfonylspiro[indole-3,4'-piperidine]-2-one	Investigative	57386011	C23H21N3O3S	419.5	C1CN(CCC12C3=CC=CC=C3N(C2=O)C4=CC=CC=C4)S(=O)(=O)C5=CC=CC=N5	IC50 ~ 50000 nM	Poor binder
T32880	HIF-prolyl hydroxylase 2	BFK6T3	1-Benzyl-8-hydroxy-2-oxo-N-(2H-tetrazol-5-ylmethyl)-1,6-naphthyridine-7-carboxamide	Investigative	60151131	C18H15N7O3	377.4	C1=CC=C(C=C1)CN2C(=O)C=CC3=CN=C(C(=C32)O)C(=O)NCC4=NNN=N4	IC50 = 138000 nM	Poor binder
T32880	HIF-prolyl hydroxylase 2	BFL6X7	(3S)-3-[(1-Cyano-4-hydroxy-7-phenoxyisoquinoline-3-carbonyl)amino]butanoic acid	Investigative	71736905	C21H17N3O5	391.4	C[C@@H](CC(=O)O)NC(=O)C1=C(C2=C(C=C(C=C2)OC3=CC=CC=C3)C(=N1)C#N)O	IC50 = 96750 nM	Poor binder
T32880	HIF-prolyl hydroxylase 2	BGA0Y8	4-[[4-Hydroxy-7-(phenylcarbamoylamino)isoquinoline-3-carbonyl]amino]butanoic acid	Investigative	89813172	C21H20N4O5	408.4	C1=CC=C(C=C1)NC(=O)NC2=CC3=CN=C(C(=C3C=C2)O)C(=O)NCCCC(=O)O	IC50 = 72270 nM	Poor binder
T32880	HIF-prolyl hydroxylase 2	BGE1F9	3-[(4-Hydroxy-7-phenoxy-1-phenylisoquinoline-3-carbonyl)amino]-2,2-dimethylpropanoic acid	Investigative	71735621	C27H24N2O5	456.5	CC(C)(CNC(=O)C1=C(C2=C(C=C(C=C2)OC3=CC=CC=C3)C(=N1)C4=CC=CC=C4)O)C(=O)O	IC50 = 88420 nM	Poor binder
T32880	HIF-prolyl hydroxylase 2	BGW10K	3-[(1-Cyano-4-hydroxy-2-oxido-7-phenoxyisoquinolin-2-ium-3-carbonyl)amino]-2,2-dimethylpropanoic acid	Investigative	89812974	C22H19N3O6	421.4	CC(C)(CNC(=O)C1=C(C2=C(C=C(C=C2)OC3=CC=CC=C3)C(=[N+]1[O-])C#N)O)C(=O)O	IC50 = 200000 nM	Poor binder
T32880	HIF-prolyl hydroxylase 2	BH49YI	(2S,3S)-3-[(1-Cyano-4-hydroxy-7-phenoxyisoquinoline-3-carbonyl)amino]-2-methylbutanoic acid	Investigative	71737227	C22H19N3O5	405.4	C[C@@H]([C@H](C)NC(=O)C1=C(C2=C(C=C(C=C2)OC3=CC=CC=C3)C(=N1)C#N)O)C(=O)O	IC50 = 107220 nM	Poor binder
T32880	HIF-prolyl hydroxylase 2	BH5X9W	3-[(1-Benzyl-5-cyano-8-hydroxy-2-oxo-1,2-dihydro-[1,6]naphthyridine-7-carbonyl)-amino]-propionic acid	Investigative	68297411	C20H16N4O5	392.4	C1=CC=C(C=C1)CN2C(=O)C=CC3=C(N=C(C(=C32)O)C(=O)NCCC(=O)O)C#N	IC50 = 65000 nM	Poor binder
T32880	HIF-prolyl hydroxylase 2	BH7X3C	4-{[(1-Cyano-4-hydroxy-7-phenoxy-isoquinoline-3-carbonyl)-amino]-methyl}-1-oxo-hexahydro-1lambda4-thiopyran-4-carboxylic acid	Investigative	117843708	C24H21N3O6S	479.5	C1CS(=O)CCC1(CNC(=O)C2=C(C3=C(C=C(C=C3)OC4=CC=CC=C4)C(=N2)C#N)O)C(=O)O	IC50 = 200000 nM	Poor binder
T32880	HIF-prolyl hydroxylase 2	BHL3Z8	(R)-3-{[5-Hydroxy-2-oxo-3-phenyl-1-(1-phenyl-ethyl)-8-pyridin-3-yl-1,2-dihydro-[1,7]naphthyridine-6-carbonyl]-amino}-propionic acid	Investigative	60151967	C31H26N4O5	534.6	C[C@H](C1=CC=CC=C1)N2C3=C(C=C(C2=O)C4=CC=CC=C4)C(=C(N=C3C5=CN=CC=C5)C(=O)NCCC(=O)O)O	IC50 = 195500 nM	Poor binder
T32880	HIF-prolyl hydroxylase 2	BHOC29	(1R)-2-[(1-Cyano-4-hydroxy-7-phenoxyisoquinoline-3-carbonyl)amino]cyclohexane-1-carboxylic acid	Investigative	117850101	C24H21N3O5	431.4	C1CCC([C@@H](C1)C(=O)O)NC(=O)C2=C(C3=C(C=C(C=C3)OC4=CC=CC=C4)C(=N2)C#N)O	IC50 = 181550 nM	Poor binder
T32880	HIF-prolyl hydroxylase 2	BHS25Q	3-[9-(Dimethylamino)nonanoyl-hydroxyamino]propanoic acid;hydrochloride	Investigative	46899606	C14H29ClN2O4	324.84	CN(C)CCCCCCCCC(=O)N(CCC(=O)O)O.Cl	IC50 ~ 100000 nM	Poor binder
T32880	HIF-prolyl hydroxylase 2	BI70TM	1-{[(7-Benzyl-1-cyano-4-hydroxy-8-oxo-7,8-dihydro-[2,7]naphthyridine-3-carbonyl)-amino]-methyl}-cyclobutanecarboxylic acid	Investigative	68297473	C23H20N4O5	432.4	C1CC(C1)(CNC(=O)C2=C(C3=C(C(=N2)C#N)C(=O)N(C=C3)CC4=CC=CC=C4)O)C(=O)O	IC50 = 182000 nM	Poor binder
T32880	HIF-prolyl hydroxylase 2	BIC69Y	3-[(1-Cyano-4-hydroxy-7-phenoxyisoquinoline-3-carbonyl)amino]-5-methylhexanoic acid	Investigative	89812933	C24H23N3O5	433.5	CC(C)CC(CC(=O)O)NC(=O)C1=C(C2=C(C=C(C=C2)OC3=CC=CC=C3)C(=N1)C#N)O	IC50 = 53520 nM	Poor binder
T32880	HIF-prolyl hydroxylase 2	BIPC85	(R)-2-[(7-Benzyl-1-cyano-4-hydroxy-8-oxo-7,8-dihydro-[2,7]naphthyridine-3-carbonyl)-amino]-propionic acid	Investigative	68297662	C20H16N4O5	392.4	C[C@H](C(=O)O)NC(=O)C1=C(C2=C(C(=N1)C#N)C(=O)N(C=C2)CC3=CC=CC=C3)O	IC50 = 153000 nM	Poor binder
T32880	HIF-prolyl hydroxylase 2	BIW0L2	3-[(1-Benzyl-5-hydroxy-8-methyl-2-oxo-3-phenyl-1,2-dihydro-[1,7]naphthyridine-6-carbonyl)-amino]-propionic acid	Investigative	68297205	C26H23N3O5	457.5	CC1=C2C(=C(C(=N1)C(=O)NCCC(=O)O)O)C=C(C(=O)N2CC3=CC=CC=C3)C4=CC=CC=C4	IC50 = 88000 nM	Poor binder
T32880	HIF-prolyl hydroxylase 2	BIXF84	(3-Carboxypropanoylamino)-trimethylazanium	Investigative	71453382	C7H15N2O3+	175.21	C[N+](C)(C)NC(=O)CCC(=O)O	IC50 ~ 100000 nM	Poor binder
T32880	HIF-prolyl hydroxylase 2	BJ7UT9	7-Benzyl-1-cyano-4-hydroxy-8-oxo-N-(pyridin-4-ylmethyl)-2,7-naphthyridine-3-carboxamide	Investigative	60150852	C23H17N5O3	411.4	C1=CC=C(C=C1)CN2C=CC3=C(C2=O)C(=NC(=C3O)C(=O)NCC4=CC=NC=C4)C#N	IC50 = 195000 nM	Poor binder
T32880	HIF-prolyl hydroxylase 2	BJ8C4R	2-(1H-Benzimidazole-2-carbonylamino)acetic acid	Investigative	44469096	C10H9N3O3	219.2	C1=CC=C2C(=C1)NC(=N2)C(=O)NCC(=O)O	IC50 ~ 100000 nM	Poor binder
T32880	HIF-prolyl hydroxylase 2	BJN4C7	2-[1-[[(1-Cyano-4-hydroxy-7-phenoxyisoquinoline-3-carbonyl)amino]methyl]cyclohexyl]acetic acid	Investigative	71737521	C26H25N3O5	459.5	C1CCC(CC1)(CC(=O)O)CNC(=O)C2=C(C3=C(C=C(C=C3)OC4=CC=CC=C4)C(=N2)C#N)O	IC50 = 56550 nM	Poor binder
T32880	HIF-prolyl hydroxylase 2	BK5L2P	3-{[1-Benzyl-5-hydroxy-8-(2-methyl-pyridin-3-yl)-2-oxo-3-phenyl-1,2-dihydro-[1,7]naphthyridine-6-carbonyl]-amino}-propionic acid	Investigative	68297705	C31H26N4O5	534.6	CC1=C(C=CC=N1)C2=NC(=C(C3=C2N(C(=O)C(=C3)C4=CC=CC=C4)CC5=CC=CC=C5)O)C(=O)NCCC(=O)O	IC50 = 198900 nM	Poor binder
T32880	HIF-prolyl hydroxylase 2	BK5VT4	2-[1-[(1-Cyano-4-hydroxy-7-phenoxyisoquinoline-3-carbonyl)amino]cyclobutyl]acetic acid	Investigative	89813162	C23H19N3O5	417.4	C1CC(C1)(CC(=O)O)NC(=O)C2=C(C3=C(C=C(C=C3)OC4=CC=CC=C4)C(=N2)C#N)O	IC50 = 74450 nM	Poor binder
T32880	HIF-prolyl hydroxylase 2	BL3UT2	3-[(4-Hydroxy-7-phenylsulfanylisoquinoline-3-carbonyl)amino]-2,2-dimethylpropanoic acid	Investigative	89814593	C21H20N2O4S	396.5	CC(C)(CNC(=O)C1=NC=C2C=C(C=CC2=C1O)SC3=CC=CC=C3)C(=O)O	IC50 = 63120 nM	Poor binder
T32880	HIF-prolyl hydroxylase 2	BLF75M	3-[(4-Hydroxy-7-phenoxyisoquinoline-3-carbonyl)amino]-2-phenylpropanoic acid	Investigative	71735461	C25H20N2O5	428.4	C1=CC=C(C=C1)C(CNC(=O)C2=NC=C3C=C(C=CC3=C2O)OC4=CC=CC=C4)C(=O)O	IC50 = 152700 nM	Poor binder
T32880	HIF-prolyl hydroxylase 2	BLU46Z	3-[(1-Cyano-4-hydroxy-7-phenoxyisoquinoline-3-carbonyl)amino]butanoic acid	Investigative	78164572	C21H17N3O5	391.4	CC(CC(=O)O)NC(=O)C1=C(C2=C(C=C(C=C2)OC3=CC=CC=C3)C(=N1)C#N)O	IC50 = 56640 nM	Poor binder
T32880	HIF-prolyl hydroxylase 2	BMIO06	3-[[1-Benzyl-5-hydroxy-8-(2-methylsulfanylpyrimidin-5-yl)-2-oxo-3-phenyl-1,7-naphthyridine-6-carbonyl]amino]propanoic acid	Investigative	68297200	C30H25N5O5S	567.6	CSC1=NC=C(C=N1)C2=NC(=C(C3=C2N(C(=O)C(=C3)C4=CC=CC=C4)CC5=CC=CC=C5)O)C(=O)NCCC(=O)O	IC50 = 54000 nM	Poor binder
T32880	HIF-prolyl hydroxylase 2	BMS01Y	3-[(1-Benzyl-5-hydroxy-2-oxo-3-phenyl-1,2,3,4-tetrahydro-[1,7]naphthyridine-6-carbonyl)-amino]-propionic acid	Investigative	60151539	C25H23N3O5	445.5	C1C(C(=O)N(C2=CN=C(C(=C21)O)C(=O)NCCC(=O)O)CC3=CC=CC=C3)C4=CC=CC=C4	IC50 = 132000 nM	Poor binder
T32880	HIF-prolyl hydroxylase 2	BMSE15	3-[[7-[(4-Fluorobenzoyl)amino]-4-hydroxyisoquinoline-3-carbonyl]amino]propanoic acid	Investigative	71735944	C20H16FN3O5	397.4	C1=CC(=CC=C1C(=O)NC2=CC3=CN=C(C(=C3C=C2)O)C(=O)NCCC(=O)O)F	IC50 = 112940 nM	Poor binder
T32880	HIF-prolyl hydroxylase 2	BN0Z2M	(S)-2-[(1-Benzyl-8-cyano-5-hydroxy-2-oxo-3-phenyl-1,2-dihydro-[1,7]naphthyridine-6-carbonyl)-amino]-3-phenyl-propionic acid	Investigative	60150849	C32H24N4O5	544.6	C1=CC=C(C=C1)C[C@@H](C(=O)O)NC(=O)C2=C(C3=C(C(=N2)C#N)N(C(=O)C(=C3)C4=CC=CC=C4)CC5=CC=CC=C5)O	IC50 = 144000 nM	Poor binder
T32880	HIF-prolyl hydroxylase 2	BN0ZA8	1'-[(4-Methyl-1,2,4-triazol-3-yl)methyl]-1-quinolin-3-ylspiro[indole-3,4'-piperidine]-2-one	Investigative	57385736	C25H24N6O	424.5	CN1C=NN=C1CN2CCC3(CC2)C4=CC=CC=C4N(C3=O)C5=CC6=CC=CC=C6N=C5	IC50 ~ 50000 nM	Poor binder
T32880	HIF-prolyl hydroxylase 2	BN86AV	N'1,N'1,N'4,N'4-Tetramethylsuccinohydrazide	Investigative	2238068	C8H18N4O2	202.25	CN(C)NC(=O)CCC(=O)NN(C)C	IC50 ~ 100000 nM	Poor binder
T32880	HIF-prolyl hydroxylase 2	BNA94M	3-[10-(Dimethylamino)decanoyl-hydroxyamino]propanoic acid;hydrochloride	Investigative	46899608	C15H31ClN2O4	338.87	CN(C)CCCCCCCCCC(=O)N(CCC(=O)O)O.Cl	IC50 ~ 100000 nM	Poor binder
T32880	HIF-prolyl hydroxylase 2	BO1JC5	Picolinoylglycine	Investigative	11788622	C8H8N2O3	180.16	C1=CC=NC(=C1)C(=O)NCC(=O)O	IC50 ~ 100000 nM	Poor binder
T32880	HIF-prolyl hydroxylase 2	BO5GT3	(2S,3R)-3-[(1-Cyano-4-hydroxy-7-phenoxyisoquinoline-3-carbonyl)amino]-2-methylbutanoic acid	Investigative	71737231	C22H19N3O5	405.4	C[C@@H]([C@@H](C)NC(=O)C1=C(C2=C(C=C(C=C2)OC3=CC=CC=C3)C(=N1)C#N)O)C(=O)O	IC50 = 65810 nM	Poor binder
T32880	HIF-prolyl hydroxylase 2	BO84YU	3-[(1-Benzyl-5-hydroxy-2-oxo-3-phenyl-8-pyridin-3-yl-1,2-dihydro-[1,7]naphthyridine-6-carbonyl)-amino]-2,2-dimethyl-propionic acid	Investigative	68297531	C32H28N4O5	548.6	CC(C)(CNC(=O)C1=C(C2=C(C(=N1)C3=CN=CC=C3)N(C(=O)C(=C2)C4=CC=CC=C4)CC5=CC=CC=C5)O)C(=O)O	IC50 = 200000 nM	Poor binder
T32880	HIF-prolyl hydroxylase 2	BO98ZH	3-[(1-Benzyl-5-hydroxy-2-oxo-3-phenyl-8-pyridin-2-yl-1,2-dihydro-[1,7]naphthyridine-6-carbonyl)-amino]-propionic acid	Investigative	135981263	C30H24N4O5	520.5	C1=CC=C(C=C1)CN2C3=C(C=C(C2=O)C4=CC=CC=C4)C(=C(N=C3C5=CC=CC=N5)C(=O)NCCC(=O)O)O	IC50 = 163800 nM	Poor binder
T32880	HIF-prolyl hydroxylase 2	BON9Q2	3-[(1-Benzyl-5-hydroxy-2-oxo-3-phenyl-8-thiazol-2-yl-1,2-dihydro-[1,7]naphthyridine-6-carbonyl)-amino]-propionic acid	Investigative	136377250	C28H22N4O5S	526.6	C1=CC=C(C=C1)CN2C3=C(C=C(C2=O)C4=CC=CC=C4)C(=C(N=C3C5=NC=CS5)C(=O)NCCC(=O)O)O	IC50 = 137500 nM	Poor binder
T32880	HIF-prolyl hydroxylase 2	BOTR41	3-[(7-Benzyl-4-hydroxyisoquinoline-3-carbonyl)amino]-2,2-dimethylpropanoic acid	Investigative	71736593	C22H22N2O4	378.4	CC(C)(CNC(=O)C1=NC=C2C=C(C=CC2=C1O)CC3=CC=CC=C3)C(=O)O	IC50 = 180770 nM	Poor binder
T32880	HIF-prolyl hydroxylase 2	BP9OA4	1-[(1-Benzyl-5-hydroxy-2-oxo-3-phenyl-1,2-dihydro-[1,7]naphthyridine-6-carbonyl)-amino]-cyclopropanecarboxylic acid	Investigative	68297228	C26H21N3O5	455.5	C1CC1(C(=O)O)NC(=O)C2=NC=C3C(=C2O)C=C(C(=O)N3CC4=CC=CC=C4)C5=CC=CC=C5	IC50 = 51800 nM	Poor binder
T32880	HIF-prolyl hydroxylase 2	BP9YQ6	4-Hydrazinyl-4-oxobutanoic acid	Investigative	222878	C4H8N2O3	132.12	C(CC(=O)O)C(=O)NN	IC50 ~ 100000 nM	Poor binder
T32880	HIF-prolyl hydroxylase 2	BPAG79	5-[(1-Cyano-4-hydroxy-6-phenoxyisoquinoline-3-carbonyl)amino]pentanoic acid	Investigative	89812924	C22H19N3O5	405.4	C1=CC=C(C=C1)OC2=CC3=C(C=C2)C(=NC(=C3O)C(=O)NCCCCC(=O)O)C#N	IC50 = 65150 nM	Poor binder
T32880	HIF-prolyl hydroxylase 2	BPI60N	8-Hydroxyquinoline-7-carboxylic acid	Investigative	231363	C10H7NO3	189.17	C1=CC2=C(C(=C(C=C2)C(=O)O)O)N=C1	IC50 ~ 100000 nM	Poor binder
T32880	HIF-prolyl hydroxylase 2	BQ3R4I	5-[[7-(4-Fluorophenyl)-4-hydroxyisoquinoline-3-carbonyl]amino]pentanoic acid	Investigative	71736592	C21H19FN2O4	382.4	C1=CC(=CC=C1C2=CC3=CN=C(C(=C3C=C2)O)C(=O)NCCCCC(=O)O)F	IC50 = 86950 nM	Poor binder
T32880	HIF-prolyl hydroxylase 2	BQBO01	3-[8-(Dimethylamino)octanoyl-hydroxyamino]propanoic acid;hydrochloride	Investigative	46899604	C13H27ClN2O4	310.82	CN(C)CCCCCCCC(=O)N(CCC(=O)O)O.Cl	IC50 ~ 100000 nM	Poor binder
T32880	HIF-prolyl hydroxylase 2	BQC4F5	4-[(4-Hydroxy-7-phenoxyisoquinoline-3-carbonyl)amino]-2,2-dimethylbutanoic acid	Investigative	89812979	C22H22N2O5	394.4	CC(C)(CCNC(=O)C1=NC=C2C=C(C=CC2=C1O)OC3=CC=CC=C3)C(=O)O	IC50 = 118550 nM	Poor binder
T32880	HIF-prolyl hydroxylase 2	BQXN30	1-Benzyl-8-cyano-5-hydroxy-N-[2-[methyl(methylsulfonyl)amino]ethyl]-2-oxo-3-phenyl-1,7-naphthyridine-6-carboxamide	Investigative	86714134	C27H25N5O5S	531.6	CN(CCNC(=O)C1=C(C2=C(C(=N1)C#N)N(C(=O)C(=C2)C3=CC=CC=C3)CC4=CC=CC=C4)O)S(=O)(=O)C	IC50 = 86900 nM	Poor binder
T32880	HIF-prolyl hydroxylase 2	BR65JP	3-[[4-Hydroxy-7-[(4-methoxyphenyl)methylamino]isoquinoline-3-carbonyl]amino]-2,2-dimethylpropanoic acid	Investigative	89812929	C23H25N3O5	423.5	CC(C)(CNC(=O)C1=NC=C2C=C(C=CC2=C1O)NCC3=CC=C(C=C3)OC)C(=O)O	IC50 = 200000 nM	Poor binder
T32880	HIF-prolyl hydroxylase 2	BR8HJ6	3-[[1-Cyano-7-[(4-fluorobenzoyl)amino]-4-hydroxyisoquinoline-3-carbonyl]amino]-2,2-dimethylpropanoic acid	Investigative	89812827	C23H19FN4O5	450.4	CC(C)(CNC(=O)C1=C(C2=C(C=C(C=C2)NC(=O)C3=CC=C(C=C3)F)C(=N1)C#N)O)C(=O)O	IC50 = 200000 nM	Poor binder
T32880	HIF-prolyl hydroxylase 2	BRL17K	2-[[4-(4-Chlorophenyl)pyridine-2-carbonyl]amino]acetic acid	Investigative	24891150	C14H11ClN2O3	290.7	C1=CC(=CC=C1C2=CC(=NC=C2)C(=O)NCC(=O)O)Cl	IC50 ~ 100000 nM	Poor binder
T32880	HIF-prolyl hydroxylase 2	BRWX50	3-[Acetyl(hydroxy)amino]propanoic acid	Investigative	22959876	C5H9NO4	147.13	CC(=O)N(CCC(=O)O)O	IC50 ~ 100000 nM	Poor binder
T32880	HIF-prolyl hydroxylase 2	BSY2I9	3-[(6-Benzyl-4-hydroxy-5-oxo-5,6-dihydro-[2,6]naphthyridine-3-carbonyl)-amino]-propionic acid	Investigative	68297589	C19H17N3O5	367.4	C1=CC=C(C=C1)CN2C=CC3=CN=C(C(=C3C2=O)O)C(=O)NCCC(=O)O	IC50 = 181000 nM	Poor binder
T32880	HIF-prolyl hydroxylase 2	BT3CM7	(2R,3S)-3-[(1-Cyano-4-hydroxy-7-phenoxyisoquinoline-3-carbonyl)amino]-2-methylbutanoic acid	Investigative	71737230	C22H19N3O5	405.4	C[C@H]([C@H](C)NC(=O)C1=C(C2=C(C=C(C=C2)OC3=CC=CC=C3)C(=N1)C#N)O)C(=O)O	IC50 = 200000 nM	Poor binder
T32880	HIF-prolyl hydroxylase 2	BT9X0L	1-Benzyl-5-hydroxy-N-[2-[methyl(methylsulfonyl)amino]ethyl]-2-oxo-3-phenyl-8-pyridin-3-yl-1,7-naphthyridine-6-carboxamide	Investigative	60151682	C31H29N5O5S	583.7	CN(CCNC(=O)C1=C(C2=C(C(=N1)C3=CN=CC=C3)N(C(=O)C(=C2)C4=CC=CC=C4)CC5=CC=CC=C5)O)S(=O)(=O)C	IC50 = 200000 nM	Poor binder
T32880	HIF-prolyl hydroxylase 2	BTV25W	3-[(1-Cyano-7-cyclohexylsulfonyl-4-hydroxyisoquinoline-3-carbonyl)amino]-2,2-dimethylpropanoic acid	Investigative	71736260	C22H25N3O6S	459.5	CC(C)(CNC(=O)C1=C(C2=C(C=C(C=C2)S(=O)(=O)C3CCCCC3)C(=N1)C#N)O)C(=O)O	IC50 = 200000 nM	Poor binder
T32880	HIF-prolyl hydroxylase 2	BU6A5D	3-[(1-Cyano-4-hydroxy-7-phenylmethoxyisoquinoline-3-carbonyl)amino]-3-methylbutanoic acid	Investigative	71736591	C23H21N3O5	419.4	CC(C)(CC(=O)O)NC(=O)C1=C(C2=C(C=C(C=C2)OCC3=CC=CC=C3)C(=N1)C#N)O	IC50 = 55050 nM	Poor binder
T32880	HIF-prolyl hydroxylase 2	BUAD62	1-Benzyl-N-[2-(ethylcarbamoylamino)ethyl]-5-hydroxy-2-oxo-3-phenyl-1,7-naphthyridine-6-carboxamide	Investigative	86714128	C27H27N5O4	485.5	CCNC(=O)NCCNC(=O)C1=NC=C2C(=C1O)C=C(C(=O)N2CC3=CC=CC=C3)C4=CC=CC=C4	IC50 = 200000 nM	Poor binder
T32880	HIF-prolyl hydroxylase 2	BUF35E	4-[[7-[(4-Fluorophenyl)carbamoylamino]-4-hydroxyisoquinoline-3-carbonyl]amino]butanoic acid	Investigative	71735143	C21H19FN4O5	426.4	C1=CC(=CC=C1NC(=O)NC2=CC3=CN=C(C(=C3C=C2)O)C(=O)NCCCC(=O)O)F	IC50 = 56350 nM	Poor binder
T32880	HIF-prolyl hydroxylase 2	BV5W4Z	2-(S)-Tert-Butoxycarbonylamino-3-[(1-cyano-4-hydroxy-7-phenoxy-isoquinoline-3-carbonyl)-amino]-propionic acid	Investigative	71737070	C25H24N4O7	492.5	CC(C)(C)OC(=O)N[C@@H](CNC(=O)C1=C(C2=C(C=C(C=C2)OC3=CC=CC=C3)C(=N1)C#N)O)C(=O)O	IC50 = 112250 nM	Poor binder
T32880	HIF-prolyl hydroxylase 2	BV6ZS4	(R)-3-(1-Cyano-4-hydroxy-7-phenoxyisoquinoline-3-carboxamido)-4-hydroxybutanoic acid	Investigative	71737526	C21H17N3O6	407.4	C1=CC=C(C=C1)OC2=CC3=C(C=C2)C(=C(N=C3C#N)C(=O)N[C@H](CC(=O)O)CO)O	IC50 = 158640 nM	Poor binder
T32880	HIF-prolyl hydroxylase 2	BVE23M	4-[Dimethylamino(methyl)amino]-4-oxobutanoic acid	Investigative	71451542	C7H14N2O3	174.2	CN(C)N(C)C(=O)CCC(=O)O	IC50 ~ 100000 nM	Poor binder
T32880	HIF-prolyl hydroxylase 2	BVE38W	3-[(1-Benzyl-5-hydroxy-2-oxo-1,2-dihydro-[1,7]naphthyridine-6-carbonyl)-amino]-propionic acid	Investigative	60151540	C19H17N3O5	367.4	C1=CC=C(C=C1)CN2C(=O)C=CC3=C(C(=NC=C32)C(=O)NCCC(=O)O)O	IC50 = 75000 nM	Poor binder
T32880	HIF-prolyl hydroxylase 2	BVPH69	5-Quinolinecarboxylic acid, 8-hydroxy-, octyl ester	Investigative	125377518	C18H23NO3	301.4	CCCCCCCCOC(=O)C1=C2C=CC=NC2=C(C=C1)O	IC50 ~ 100000 nM	Poor binder
T32880	HIF-prolyl hydroxylase 2	BVWN90	4-Carboxymethyl-4-[(1-cyano-4-hydroxy-7-phenoxy-isoquinoline-3-carbonyl)-amino]-piperidine-1-carboxylic acid tert-butyl ester	Investigative	71735144	C29H30N4O7	546.6	CC(C)(C)OC(=O)N1CCC(CC1)(CC(=O)O)NC(=O)C2=C(C3=C(C=C(C=C3)OC4=CC=CC=C4)C(=N2)C#N)O	IC50 = 157720 nM	Poor binder
T32880	HIF-prolyl hydroxylase 2	BW3U8R	3-[(5-Hydroxy-2-oxo-1,3-diphenyl-8-pyridin-4-yl-1,2-dihydro-[1,7]naphthyridine-6-carbonyl)-amino]-propionic acid	Investigative	135981267	C29H22N4O5	506.5	C1=CC=C(C=C1)C2=CC3=C(C(=NC(=C3O)C(=O)NCCC(=O)O)C4=CC=NC=C4)N(C2=O)C5=CC=CC=C5	IC50 = 200000 nM	Poor binder
T32880	HIF-prolyl hydroxylase 2	BW61IC	4-[[7-[(4-Fluorobenzoyl)amino]-4-hydroxyisoquinoline-3-carbonyl]amino]butanoic acid	Investigative	89813144	C21H18FN3O5	411.4	C1=CC(=CC=C1C(=O)NC2=CC3=CN=C(C(=C3C=C2)O)C(=O)NCCCC(=O)O)F	IC50 = 200000 nM	Poor binder
T32880	HIF-prolyl hydroxylase 2	BW92TB	1-[(1-Benzyl-5-hydroxy-2-oxo-3-phenyl-8-pyridin-3-yl-1,2-dihydro-[1,7]naphthyridine-6-carbonyl)-amino]-cyclopropanecarboxylic acid	Investigative	68297657	C31H24N4O5	532.5	C1CC1(C(=O)O)NC(=O)C2=C(C3=C(C(=N2)C4=CN=CC=C4)N(C(=O)C(=C3)C5=CC=CC=C5)CC6=CC=CC=C6)O	IC50 = 55200 nM	Poor binder
T32880	HIF-prolyl hydroxylase 2	BWO64I	3-[[5-Hydroxy-1-(oxan-4-ylmethyl)-2-oxo-3-phenyl-8-pyridin-3-yl-1,7-naphthyridine-6-carbonyl]amino]propanoic acid	Investigative	60152113	C29H28N4O6	528.6	C1COCCC1CN2C3=C(C=C(C2=O)C4=CC=CC=C4)C(=C(N=C3C5=CN=CC=C5)C(=O)NCCC(=O)O)O	IC50 = 65300 nM	Poor binder
T32880	HIF-prolyl hydroxylase 2	BWOZ57	N-(2-Acetamidoethyl)-1-benzyl-8-hydroxy-2-oxo-1,6-naphthyridine-7-carboxamide	Investigative	86714123	C20H20N4O4	380.4	CC(=O)NCCNC(=O)C1=NC=C2C=CC(=O)N(C2=C1O)CC3=CC=CC=C3	IC50 = 137000 nM	Poor binder
T32880	HIF-prolyl hydroxylase 2	BWXP54	Oc1cccnc1-c1nc(CC(=O)NCc2ccccc2)cs1	Investigative	135871167	C17H15N3O2S	325.4	C1=CC=C(C=C1)CNC(=O)CC2=CSC(=N2)C3=C(C=CC=N3)O	IC50 = 81000 nM	Poor binder
T32880	HIF-prolyl hydroxylase 2	BX2KL8	1'-(Pyrazin-2-ylmethyl)-1-quinolin-3-ylspiro[indole-3,4'-piperidine]-2-one	Investigative	57386006	C26H23N5O	421.5	C1CN(CCC12C3=CC=CC=C3N(C2=O)C4=CC5=CC=CC=C5N=C4)CC6=NC=CN=C6	IC50 ~ 50000 nM	Poor binder
T32880	HIF-prolyl hydroxylase 2	BX3S7Q	3-[(1-Cyano-4-hydroxy-6-phenoxyisoquinoline-3-carbonyl)amino]-2,2-dimethylpropanoic acid	Investigative	71736100	C22H19N3O5	405.4	CC(C)(CNC(=O)C1=C(C2=C(C=CC(=C2)OC3=CC=CC=C3)C(=N1)C#N)O)C(=O)O	IC50 = 183240 nM	Poor binder
T32880	HIF-prolyl hydroxylase 2	BX5D6S	(R)-2-[(1-Benzyl-8-cyano-5-hydroxy-2-oxo-3-phenyl-1,2-dihydro-[1,7]naphthyridine-6-carbonyl)-amino]-3-phenyl-propionic acid	Investigative	86714112	C32H24N4O5	544.6	C1=CC=C(C=C1)C[C@H](C(=O)O)NC(=O)C2=C(C3=C(C(=N2)C#N)N(C(=O)C(=C3)C4=CC=CC=C4)CC5=CC=CC=C5)O	IC50 = 129000 nM	Poor binder
T32880	HIF-prolyl hydroxylase 2	BX8MB3	5-[[7-(2,6-Difluorophenoxy)-4-hydroxyisoquinoline-3-carbonyl]amino]pentanoic acid	Investigative	89813022	C21H18F2N2O5	416.4	C1=CC(=C(C(=C1)F)OC2=CC3=CN=C(C(=C3C=C2)O)C(=O)NCCCCC(=O)O)F	IC50 = 200000 nM	Poor binder
T32880	HIF-prolyl hydroxylase 2	BXQ3L1	N-(2-Acetamidoethyl)-1-benzyl-5-cyano-8-hydroxy-2-oxo-1,6-naphthyridine-7-carboxamide	Investigative	86714122	C21H19N5O4	405.4	CC(=O)NCCNC(=O)C1=NC(=C2C=CC(=O)N(C2=C1O)CC3=CC=CC=C3)C#N	IC50 = 134000 nM	Poor binder
T32880	HIF-prolyl hydroxylase 2	BXU5C1	(S)-3-{[5-Hydroxy-2-oxo-3-phenyl-1-(1-phenyl-ethyl)-8-pyridin-3-yl-1,2-dihydro-[1,7]naphthyridine-6-carbonyl]amino}-propionic acid	Investigative	68297489	C31H26N4O5	534.6	C[C@@H](C1=CC=CC=C1)N2C3=C(C=C(C2=O)C4=CC=CC=C4)C(=C(N=C3C5=CN=CC=C5)C(=O)NCCC(=O)O)O	IC50 = 200000 nM	Poor binder
T32880	HIF-prolyl hydroxylase 2	BY2PV4	(R)-3-[(1-Benzyl-5-hydroxy-2-oxo-3-phenyl-1,2-dihydro-[1,7]naphthyridine-6-carbonyl)-amino]-butyric acid	Investigative	68297478	C26H23N3O5	457.5	C[C@H](CC(=O)O)NC(=O)C1=NC=C2C(=C1O)C=C(C(=O)N2CC3=CC=CC=C3)C4=CC=CC=C4	IC50 = 87900 nM	Poor binder
T32880	HIF-prolyl hydroxylase 2	BYZJ90	3-[[4-Hydroxy-7-phenoxy-1-(trifluoromethyl)isoquinoline-3-carbonyl]amino]propanoic acid	Investigative	71736436	C20H15F3N2O5	420.3	C1=CC=C(C=C1)OC2=CC3=C(C=C2)C(=C(N=C3C(F)(F)F)C(=O)NCCC(=O)O)O	IC50 = 101240 nM	Poor binder
T32880	HIF-prolyl hydroxylase 2	BZI04L	4-[[7-(Cyclohexylcarbamoylamino)-4-hydroxyisoquinoline-3-carbonyl]amino]butanoic acid	Investigative	89813114	C21H26N4O5	414.5	C1CCC(CC1)NC(=O)NC2=CC3=CN=C(C(=C3C=C2)O)C(=O)NCCCC(=O)O	IC50 = 77600 nM	Poor binder
T32880	HIF-prolyl hydroxylase 2	BZT74G	2-[(6-Methoxy-1H-benzimidazole-2-carbonyl)amino]acetic acid	Investigative	44469229	C11H11N3O4	249.22	COC1=CC2=C(C=C1)N=C(N2)C(=O)NCC(=O)O	IC50 = 50118.72 nM	Poor binder
T32880	HIF-prolyl hydroxylase 2	D0B2WZ	daminozide	Investigative	15331	C6H12N2O3	160.17	CN(C)NC(=O)CCC(=O)O	IC50 ~ 100000 nM	Poor binder