TTD_Target_ID	Target_Name	TTD_Drug_ID	Drug_Name	Drug_Highest_Status	Drug_PubchemID	Molecular_Formula	Molecular_Weight	Canonical_SMILES	Activity	Binder_Type
T36483	Proteinase activated receptor 1	B0DF3I	2-[(E)-2-[(4Ar,6aR,7S,8S,10aS,10bR)-3,3,6a,10b-tetramethylspiro[1,4a,5,6,7,9,10,10a-octahydronaphtho[2,1-d][1,3]dioxine-8,2'-oxirane]-7-yl]ethenyl]-5-(3-fluorophenyl)pyridine	Investigative	137651696	C30H36FNO3	477.6	C[C@@]12CC[C@@H]3[C@]([C@H]1CC[C@]4([C@H]2/C=C/C5=NC=C(C=C5)C6=CC(=CC=C6)F)CO4)(COC(O3)(C)C)C	IC50 ~ 100000 nM	Poor binder
T36483	Proteinase activated receptor 1	B0IE4J	(2S)-2-[[(2S)-2-[Acetyl-[(E)-3-phenylprop-2-enoyl]amino]-3-(4-fluorophenyl)propanoyl]amino]-3-[4-(diaminomethylideneamino)phenyl]propanamide	Investigative	90663305	C30H31FN6O4	558.6	CC(=O)N([C@@H](CC1=CC=C(C=C1)F)C(=O)N[C@@H](CC2=CC=C(C=C2)N=C(N)N)C(=O)N)C(=O)/C=C/C3=CC=CC=C3	IC50 = 64000 nM	Poor binder
T36483	Proteinase activated receptor 1	B0L4ZD	[(3As,5aS,6S,7R,9aR,9bR)-6-[(E)-2-[5-(3-fluorophenyl)pyridin-2-yl]ethenyl]-6,9a-dimethyl-1-oxo-3a,4,5,5a,7,8,9,9b-octahydro-3H-benzo[e][2]benzofuran-7-yl] acetate	Investigative	137635753	C29H32FNO4	477.6	CC(=O)O[C@@H]1CC[C@@]2([C@@H]([C@]1(C)/C=C/C3=NC=C(C=C3)C4=CC(=CC=C4)F)CC[C@H]5[C@H]2C(=O)OC5)C	IC50 ~ 100000 nM	Poor binder
T36483	Proteinase activated receptor 1	B0L5OG	4-Oxo-1-[1-(3-piperidin-4-yl-propionyl)-piperidine-3-carbonyl]-piperidine-3-carboxylic acid	Investigative	15887958	C20H31N3O5	393.5	C1CC(CN(C1)C(=O)CCC2CCNCC2)C(=O)N3CCC(=O)C(C3)C(=O)O	IC50 = 65000 nM	Poor binder
T36483	Proteinase activated receptor 1	B0MIJ1	(1S,2R,4Ar,5S,6S,8aS)-5-[(E)-2-[5-(3-fluorophenyl)-1-oxidopyridin-1-ium-2-yl]ethenyl]-2-hydroxy-1,4a-dimethylspiro[3,4,5,7,8,8a-hexahydro-2H-naphthalene-6,2'-oxirane]-1-carbaldehyde	Investigative	137641321	C27H30FNO4	451.5	C[C@@]12CC[C@H]([C@@]([C@H]1CC[C@]3([C@H]2/C=C/C4=[N+](C=C(C=C4)C5=CC(=CC=C5)F)[O-])CO3)(C)C=O)O	IC50 ~ 100000 nM	Poor binder
T36483	Proteinase activated receptor 1	B1L4AH	(S)-2-{(S)-2-[(S)-2-((S)-2-Amino-3-hydroxy-propionylamino)-3-phenyl-propionylamino]-4-methyl-pentanoylamino}-4-methyl-pentanoic acid amide	Investigative	9982475	C24H39N5O5	477.6	CC(C)C[C@@H](C(=O)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC1=CC=CC=C1)NC(=O)[C@H](CO)N	EC50 = 185000 nM	Poor binder
T36483	Proteinase activated receptor 1	B1MGO0	[(2R,4As,5S,6S,8aS)-5-[(E)-2-[5-(3-fluorophenyl)pyridin-2-yl]ethenyl]-1,1,4a,6-tetramethyl-2,3,4,5,6,7,8,8a-octahydronaphthalen-2-yl] acetate	Investigative	137654736	C29H36FNO2	449.6	C[C@H]1CC[C@H]2[C@]([C@@H]1/C=C/C3=NC=C(C=C3)C4=CC(=CC=C4)F)(CC[C@H](C2(C)C)OC(=O)C)C	IC50 ~ 100000 nM	Poor binder
T36483	Proteinase activated receptor 1	B1MK4P	[(2R,4As,5S,6S,8aS)-5-[(E)-2-[5-(3-fluorophenyl)pyridin-2-yl]ethenyl]-1,1,4a,6-tetramethyl-2,3,4,5,6,7,8,8a-octahydronaphthalen-2-yl] methanesulfonate	Investigative	137652024	C28H36FNO3S	485.7	C[C@H]1CC[C@H]2[C@]([C@@H]1/C=C/C3=NC=C(C=C3)C4=CC(=CC=C4)F)(CC[C@H](C2(C)C)OS(=O)(=O)C)C	IC50 = 87000 nM	Poor binder
T36483	Proteinase activated receptor 1	B1QVP6	[(3As,5aS,6S,7S,9aR,9bR)-6-[(E)-2-[5-(3-fluorophenyl)pyridin-2-yl]ethenyl]-6,9a-dimethyl-1-oxo-3a,4,5,5a,7,8,9,9b-octahydro-3H-benzo[e][2]benzofuran-7-yl] methanesulfonate	Investigative	137632824	C28H32FNO5S	513.6	C[C@@]12CC[C@@H]([C@@]([C@H]1CC[C@H]3[C@H]2C(=O)OC3)(C)/C=C/C4=NC=C(C=C4)C5=CC(=CC=C5)F)OS(=O)(=O)C	IC50 ~ 100000 nM	Poor binder
T36483	Proteinase activated receptor 1	B2E7PT	2-[(E)-2-[(1S,2S,4Ar,8aS)-2,5,5,8a-tetramethyl-1,2,3,4,4a,8-hexahydronaphthalen-1-yl]ethenyl]-5-(3-fluorophenyl)pyridine	Investigative	137649807	C27H32FN	389.5	C[C@H]1CC[C@H]2[C@]([C@@H]1/C=C/C3=NC=C(C=C3)C4=CC(=CC=C4)F)(CC=CC2(C)C)C	IC50 ~ 100000 nM	Poor binder
T36483	Proteinase activated receptor 1	B39KRY	N-[(2S)-1-[[(2S)-1-[[(2S)-1-Amino-1-oxo-3-phenylpropan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-3-cyclohexyl-1-oxopropan-2-yl]-1H-indole-2-carboxamide	Investigative	44281264	C33H44N8O4	616.8	C1CCC(CC1)C[C@@H](C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CC2=CC=CC=C2)C(=O)N)NC(=O)C3=CC4=CC=CC=C4N3	IC50 = 56000 nM	Poor binder
T36483	Proteinase activated receptor 1	B3B0QI	[(3As,5aS,6S,7S,9aR,9bR)-6-[(E)-2-[5-(3-fluorophenyl)pyridin-2-yl]ethenyl]-6,9a-dimethyl-1-oxo-3a,4,5,5a,7,8,9,9b-octahydro-3H-benzo[e][2]benzofuran-7-yl] butanoate	Investigative	137645447	C31H36FNO4	505.6	CCCC(=O)O[C@H]1CC[C@@]2([C@@H]([C@]1(C)/C=C/C3=NC=C(C=C3)C4=CC(=CC=C4)F)CC[C@H]5[C@H]2C(=O)OC5)C	IC50 ~ 100000 nM	Poor binder
T36483	Proteinase activated receptor 1	B3BFE8	[(3As,5aS,6S,7S,9aR,9bR)-6-[(E)-2-[5-(3-fluorophenyl)pyridin-2-yl]ethenyl]-6,9a-dimethyl-1-oxo-3a,4,5,5a,7,8,9,9b-octahydro-3H-benzo[e][2]benzofuran-7-yl] acetate	Investigative	137651100	C29H32FNO4	477.6	CC(=O)O[C@H]1CC[C@@]2([C@@H]([C@]1(C)/C=C/C3=NC=C(C=C3)C4=CC(=CC=C4)F)CC[C@H]5[C@H]2C(=O)OC5)C	IC50 ~ 100000 nM	Poor binder
T36483	Proteinase activated receptor 1	B3MU4F	(3R)-N-[(2S)-1-[[(2S)-1-[[(2S)-1-Amino-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]-2-[(2S)-2-[[(2S)-2-amino-3-hydroxypropanoyl]amino]-3-phenylpropanoyl]-3,4-dihydro-1H-isoquinoline-3-carboxamide	Investigative	73347045	C40H60N10O7	793	CC(C)C[C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N)NC(=O)[C@H]1CC2=CC=CC=C2CN1C(=O)[C@H](CC3=CC=CC=C3)NC(=O)[C@H](CO)N	EC50 = 110000 nM	Poor binder
T36483	Proteinase activated receptor 1	B3X8LN	(2S)-2-[[(2S)-2-[[(2S)-2-[Acetyl(cyclopentyl)amino]-3-(4-fluorophenyl)propanoyl]amino]-3-[4-(diaminomethylideneamino)phenyl]propanoyl]amino]-N-[(2S)-1-amino-5-(diaminomethylideneamino)-1-oxopentan-2-yl]-4-methylpentanamide	Investigative	90663302	C38H56FN11O5	765.9	CC(C)C[C@@H](C(=O)N[C@@H](CCCN=C(N)N)C(=O)N)NC(=O)[C@H](CC1=CC=C(C=C1)N=C(N)N)NC(=O)[C@H](CC2=CC=C(C=C2)F)N(C3CCCC3)C(=O)C	IC50 = 85000 nM	Poor binder
T36483	Proteinase activated receptor 1	B5ZT8K	2-[(E)-2-[(4Ar,6aR,7S,8S,10aS,10bR)-3,3,6a,10b-tetramethylspiro[1,4a,5,6,7,9,10,10a-octahydronaphtho[2,1-d][1,3]dioxine-8,2'-oxirane]-7-yl]ethenyl]-5-[3-(trifluoromethyl)phenyl]pyridine	Investigative	137641036	C31H36F3NO3	527.6	C[C@@]12CC[C@@H]3[C@]([C@H]1CC[C@]4([C@H]2/C=C/C5=NC=C(C=C5)C6=CC(=CC=C6)C(F)(F)F)CO4)(COC(O3)(C)C)C	IC50 ~ 100000 nM	Poor binder
T36483	Proteinase activated receptor 1	B64RQV	N-[(2S)-1-[[(2S)-1-Amino-1-oxo-3-phenylpropan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]-1-[2-[(1S)-2-(4-fluorophenyl)-1-[[2-(methylamino)acetyl]amino]ethyl]-1,3-thiazole-4-carbonyl]piperidine-3-carboxamide	Investigative	44289951	C36H47FN10O5S	750.9	CNCC(=O)N[C@@H](CC1=CC=C(C=C1)F)C2=NC(=CS2)C(=O)N3CCCC(C3)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CC4=CC=CC=C4)C(=O)N	IC50 ~ 100000 nM	Poor binder
T36483	Proteinase activated receptor 1	B68JPH	N-[(2S)-1-[[(2S)-1-[[(2S)-1-Amino-1-oxo-3-phenylpropan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-3-cyclohexyl-1-oxopropan-2-yl]-3-[[(E)-3-(4-chlorophenyl)prop-2-enoyl]amino]-1H-1,2,4-triazole-5-carboxamide	Investigative	44280650	C36H46ClN11O5	748.3	C1CCC(CC1)C[C@@H](C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CC2=CC=CC=C2)C(=O)N)NC(=O)C3=NC(=NN3)NC(=O)/C=C/C4=CC=C(C=C4)Cl	EC50 = 55000 nM	Poor binder
T36483	Proteinase activated receptor 1	B68YZX	(2S)-2-[[(2S)-2-[[(2S)-2-[Acetyl-[(E)-3-(4-phenylphenyl)prop-2-enoyl]amino]-3-(4-fluorophenyl)propanoyl]amino]-3-[4-(diaminomethylideneamino)phenyl]propanoyl]amino]-N-[(2S)-1-amino-5-(diaminomethylideneamino)-1-oxopentan-2-yl]-4-methylpentanamide	Investigative	90663358	C48H58FN11O6	904	CC(C)C[C@@H](C(=O)N[C@@H](CCCN=C(N)N)C(=O)N)NC(=O)[C@H](CC1=CC=C(C=C1)N=C(N)N)NC(=O)[C@H](CC2=CC=C(C=C2)F)N(C(=O)C)C(=O)/C=C/C3=CC=C(C=C3)C4=CC=CC=C4	IC50 = 66700 nM	Poor binder
T36483	Proteinase activated receptor 1	B6FAK1	(2S)-2-[[(2S)-2-Acetamido-3-phenylpropanoyl]amino]-N-[(2S)-1-[[(2S)-1-amino-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]-4-methylpentanamide	Investigative	10257805	C29H48N8O5	588.7	CC(C)C[C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N)NC(=O)[C@H](CC1=CC=CC=C1)NC(=O)C	EC50 = 200000 nM	Poor binder
T36483	Proteinase activated receptor 1	B6T7CG	(1R,2R,4Ar,5S,6S,8aS)-5-[(E)-2-[5-(3-fluorophenyl)-1-oxidopyridin-1-ium-2-yl]ethenyl]-2-hydroxy-1,4a-dimethylspiro[3,4,5,7,8,8a-hexahydro-2H-naphthalene-6,2'-oxirane]-1-carbaldehyde	Investigative	137652763	C27H30FNO4	451.5	C[C@@]12CC[C@H]([C@]([C@H]1CC[C@]3([C@H]2/C=C/C4=[N+](C=C(C=C4)C5=CC(=CC=C5)F)[O-])CO3)(C)C=O)O	IC50 ~ 100000 nM	Poor binder
T36483	Proteinase activated receptor 1	B78TVZ	[(2R,4As,5S,6S,8aS)-5-[(E)-2-[5-(3-fluorophenyl)pyridin-2-yl]ethenyl]-1,1,4a,6-tetramethyl-2,3,4,5,6,7,8,8a-octahydronaphthalen-2-yl] ethyl carbonate	Investigative	137658131	C30H38FNO3	479.6	CCOC(=O)O[C@@H]1CC[C@@]2([C@@H](C1(C)C)CC[C@@H]([C@H]2/C=C/C3=NC=C(C=C3)C4=CC(=CC=C4)F)C)C	IC50 ~ 100000 nM	Poor binder
T36483	Proteinase activated receptor 1	B7G6QD	(1S,2R,4As,5R,6S,8aS)-6-(1,3-dithiolan-2-yl)-5-[(E)-2-[5-(3-fluorophenyl)pyridin-2-yl]ethenyl]-2-hydroxy-1,4a-dimethyl-2,3,4,5,6,7,8,8a-octahydronaphthalene-1-carbaldehyde	Investigative	137634922	C29H34FNO2S2	511.7	C[C@@]12CC[C@H]([C@@]([C@H]1CC[C@@H]([C@H]2/C=C/C3=NC=C(C=C3)C4=CC(=CC=C4)F)C5SCCS5)(C)C=O)O	IC50 ~ 100000 nM	Poor binder
T36483	Proteinase activated receptor 1	B7H5GY	Chembl4227184	Investigative	145967675	C18H15BrN2O2	371.2	C#CCCC(=O)NC1=CC(=CC=C1)NC(=O)C2=CC=CC=C2Br	IC50 = 81000 nM	Poor binder
T36483	Proteinase activated receptor 1	B7H6EU	(2S)-N-[(2S)-1-[[(2R)-1-Amino-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]-2-[[(2S)-2-[[(2S)-2-amino-3-hydroxypropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanamide	Investigative	10032001	C30H51N9O6	633.8	CC(C)C[C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](CCCN=C(N)N)C(=O)N)NC(=O)[C@H](CC1=CC=CC=C1)NC(=O)[C@H](CO)N	EC50 = 109300 nM	Poor binder
T36483	Proteinase activated receptor 1	B7P0KJ	[(3As,5aS,6R,7R,9aR,9bR)-6-[(E)-2-[5-(3-fluorophenyl)pyridin-2-yl]ethenyl]-6,9a-dimethyl-1-oxo-3a,4,5,5a,7,8,9,9b-octahydro-3H-benzo[e][2]benzofuran-7-yl] methanesulfonate	Investigative	137660576	C28H32FNO5S	513.6	C[C@@]12CC[C@H]([C@]([C@H]1CC[C@H]3[C@H]2C(=O)OC3)(C)/C=C/C4=NC=C(C=C4)C5=CC(=CC=C5)F)OS(=O)(=O)C	IC50 ~ 100000 nM	Poor binder
T36483	Proteinase activated receptor 1	B7PY8S	N-[(2S)-1-[[(2S)-1-[[(2S)-1-Amino-1-oxo-3-phenylpropan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-3-cyclohexyl-1-oxopropan-2-yl]-3-[[(E)-3-(1H-indol-3-yl)prop-2-enoyl]amino]-1H-1,2,4-triazole-5-carboxamide	Investigative	44281047	C38H48N12O5	752.9	C1CCC(CC1)C[C@@H](C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CC2=CC=CC=C2)C(=O)N)NC(=O)C3=NC(=NN3)NC(=O)/C=C/C4=CNC5=CC=CC=C54	IC50 = 100000 nM	Poor binder
T36483	Proteinase activated receptor 1	B8AQ9W	Methyl (1S,2R,4aR,5S,6S,8aS)-2-butanoyloxy-5-[(E)-2-[5-(3-fluorophenyl)pyridin-2-yl]ethenyl]-1,4a-dimethylspiro[3,4,5,7,8,8a-hexahydro-2H-naphthalene-6,2'-oxirane]-1-carboxylate	Investigative	137638930	C32H38FNO5	535.6	CCCC(=O)O[C@@H]1CC[C@@]2([C@@H]([C@]1(C)C(=O)OC)CC[C@]3([C@H]2/C=C/C4=NC=C(C=C4)C5=CC(=CC=C5)F)CO3)C	IC50 ~ 100000 nM	Poor binder
T36483	Proteinase activated receptor 1	B96IPS	(2S)-N-[(2S)-1-Amino-5-(diaminomethylideneamino)-1-oxopentan-2-yl]-2-[[(2S)-3-[4-(diaminomethylideneamino)phenyl]-2-[[(2S)-3-(4-fluorophenyl)-2-(thiophen-2-ylsulfonylamino)propanoyl]amino]propanoyl]amino]-4-methylpentanamide	Investigative	11803455	C35H48FN11O6S2	802	CC(C)C[C@@H](C(=O)N[C@@H](CCCN=C(N)N)C(=O)N)NC(=O)[C@H](CC1=CC=C(C=C1)N=C(N)N)NC(=O)[C@H](CC2=CC=C(C=C2)F)NS(=O)(=O)C3=CC=CS3	IC50 = 193000 nM	Poor binder
T36483	Proteinase activated receptor 1	BF2M0X	(2S)-2-[[(2S)-2-[[(2S)-3-(4-Benzoylphenyl)-2-[[(2S)-3-[4-(diaminomethylideneamino)phenyl]-2-[[(2S)-3-(4-fluorophenyl)-2-[[(E)-3-phenylprop-2-enoyl]amino]propanoyl]amino]propanoyl]amino]propanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]-5-[(4-nitro-2,1,3-benzoxadiazol-7-yl)amino]pentanoic acid	Investigative	136209460	C61H64FN15O11	1202.3	C1=CC=C(C=C1)/C=C/C(=O)N[C@@H](CC2=CC=C(C=C2)F)C(=O)N[C@@H](CC3=CC=C(C=C3)N=C(N)N)C(=O)N[C@@H](CC4=CC=C(C=C4)C(=O)C5=CC=CC=C5)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCNC6=CC=C(C7=NON=C67)[N+](=O)[O-])C(=O)O	IC50 ~ 90000 nM	Poor binder
T36483	Proteinase activated receptor 1	BF2N0E	(3As,5aS,6R,7R,9aR,9bR)-6-[(E)-2-[5-(3-fluorophenyl)pyridin-2-yl]ethenyl]-7-hydroxy-6,9a-dimethyl-3a,4,5,5a,7,8,9,9b-octahydro-3H-benzo[g][2]benzofuran-1-one	Investigative	137657212	C27H30FNO3	435.5	C[C@@]12CC[C@H]([C@]([C@H]1CC[C@H]3[C@H]2C(=O)OC3)(C)/C=C/C4=NC=C(C=C4)C5=CC(=CC=C5)F)O	IC50 ~ 100000 nM	Poor binder
T36483	Proteinase activated receptor 1	BFR71G	[(3As,5aS,6R,7S,9aR,9bR)-6-[(E)-2-[5-(3-fluorophenyl)pyridin-2-yl]ethenyl]-6,9a-dimethyl-1-oxo-3a,4,5,5a,7,8,9,9b-octahydro-3H-benzo[e][2]benzofuran-7-yl] carbamate	Investigative	137656188	C28H31FN2O4	478.6	C[C@@]12CC[C@@H]([C@]([C@H]1CC[C@H]3[C@H]2C(=O)OC3)(C)/C=C/C4=NC=C(C=C4)C5=CC(=CC=C5)F)OC(=O)N	IC50 ~ 100000 nM	Poor binder
T36483	Proteinase activated receptor 1	BFSV82	(3As,5aS,6R,7S,9aR,9bR)-6-[(E)-2-[5-(3-fluorophenyl)pyridin-2-yl]ethenyl]-7-hydroxy-6,9a-dimethyl-3a,4,5,5a,7,8,9,9b-octahydro-3H-benzo[g][2]benzofuran-1-one	Investigative	137654003	C27H30FNO3	435.5	C[C@@]12CC[C@@H]([C@]([C@H]1CC[C@H]3[C@H]2C(=O)OC3)(C)/C=C/C4=NC=C(C=C4)C5=CC(=CC=C5)F)O	IC50 ~ 100000 nM	Poor binder
T36483	Proteinase activated receptor 1	BH47LE	N-[(2S)-1-[[(2S)-1-(Benzylamino)-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-3-cyclohexyl-1-oxopropan-2-yl]-5-methyl-2-[(1S)-1-[[2-(methylamino)acetyl]amino]-2-phenylethyl]-1,3-oxazole-4-carboxamide	Investigative	44290110	C38H53N9O5	715.9	CC1=C(N=C(O1)[C@H](CC2=CC=CC=C2)NC(=O)CNC)C(=O)N[C@@H](CC3CCCCC3)C(=O)N[C@@H](CCCN=C(N)N)C(=O)NCC4=CC=CC=C4	IC50 = 60000 nM	Poor binder
T36483	Proteinase activated receptor 1	BH95BC	(2S)-2-[[(2S)-2-[[(2R)-2-[Acetyl-[(E)-3-phenylprop-2-enoyl]amino]-3-pyridin-3-ylpropanoyl]amino]-3-[4-(diaminomethylideneamino)phenyl]propanoyl]amino]-N-[(2S)-1-amino-5-(diaminomethylideneamino)-1-oxopentan-2-yl]-4-methylpentanamide	Investigative	90663324	C41H54N12O6	810.9	CC(C)C[C@@H](C(=O)N[C@@H](CCCN=C(N)N)C(=O)N)NC(=O)[C@H](CC1=CC=C(C=C1)N=C(N)N)NC(=O)[C@@H](CC2=CN=CC=C2)N(C(=O)C)C(=O)/C=C/C3=CC=CC=C3	IC50 ~ 55000 nM	Poor binder
T36483	Proteinase activated receptor 1	BID03Y	3-{[1-(3-Piperidin-4-yl-propionyl)-piperidine-3-carbonyl]-amino}-cyclohexanecarboxylic acid	Investigative	44316563	C21H35N3O4	393.5	C1CC(CC(C1)NC(=O)C2CCCN(C2)C(=O)CCC3CCNCC3)C(=O)O	IC50 ~ 50000 nM	Poor binder
T36483	Proteinase activated receptor 1	BIDA81	(2S)-2-[[(2S)-2-[[(2S)-2-[Acetyl(1H-indol-3-yl)amino]-3-(4-fluorophenyl)propanoyl]amino]-3-[4-(diaminomethylideneamino)phenyl]propanoyl]amino]-N-[(2S)-1-amino-5-(diaminomethylideneamino)-1-oxopentan-2-yl]-4-methylpentanamide	Investigative	90663299	C41H53FN12O5	812.9	CC(C)C[C@@H](C(=O)N[C@@H](CCCN=C(N)N)C(=O)N)NC(=O)[C@H](CC1=CC=C(C=C1)N=C(N)N)NC(=O)[C@H](CC2=CC=C(C=C2)F)N(C3=CNC4=CC=CC=C43)C(=O)C	IC50 = 54000 nM	Poor binder
T36483	Proteinase activated receptor 1	BJ1W4Y	2-[(1S)-1-[[(2S,3R)-2-Amino-3-methylpentanoyl]amino]-2-(4-fluorophenyl)ethyl]-N-[2-[[(2S)-1-[[(2S)-1-amino-1-oxo-3-phenylpropan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-2-oxoethyl]-N-benzyl-1,3-thiazole-4-carboxamide	Investigative	56668146	C42H53FN10O5S	829	CC[C@@H](C)[C@@H](C(=O)N[C@@H](CC1=CC=C(C=C1)F)C2=NC(=CS2)C(=O)N(CC3=CC=CC=C3)CC(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CC4=CC=CC=C4)C(=O)N)N	IC50 ~ 100000 nM	Poor binder
T36483	Proteinase activated receptor 1	BJ61MU	(2S)-2-[[(2S)-2-[[(2S)-2-(N-Acetyl-4-fluoroanilino)-3-(4-fluorophenyl)propanoyl]amino]-3-[4-(diaminomethylideneamino)phenyl]propanoyl]amino]-N-[(2S)-1-amino-5-(diaminomethylideneamino)-1-oxopentan-2-yl]-4-methylpentanamide	Investigative	90663341	C39H51F2N11O5	791.9	CC(C)C[C@@H](C(=O)N[C@@H](CCCN=C(N)N)C(=O)N)NC(=O)[C@H](CC1=CC=C(C=C1)N=C(N)N)NC(=O)[C@H](CC2=CC=C(C=C2)F)N(C3=CC=C(C=C3)F)C(=O)C	IC50 = 68000 nM	Poor binder
T36483	Proteinase activated receptor 1	BJ9MZ6	(2S)-2-[[(2S)-2-[[(2S)-2-[Acetyl(pyridin-3-yl)amino]-3-(4-fluorophenyl)propanoyl]amino]-3-[4-(diaminomethylideneamino)phenyl]propanoyl]amino]-N-[(2S)-1-amino-5-(diaminomethylideneamino)-1-oxopentan-2-yl]-4-methylpentanamide	Investigative	90663329	C38H51FN12O5	774.9	CC(C)C[C@@H](C(=O)N[C@@H](CCCN=C(N)N)C(=O)N)NC(=O)[C@H](CC1=CC=C(C=C1)N=C(N)N)NC(=O)[C@H](CC2=CC=C(C=C2)F)N(C3=CN=CC=C3)C(=O)C	IC50 ~ 160000 nM	Poor binder
T36483	Proteinase activated receptor 1	BJW08U	(3As,5aS,6S,7R,9aR,9bR)-6-[(E)-2-[5-(3-fluorophenyl)pyridin-2-yl]ethenyl]-7-hydroxy-6,9a-dimethyl-3a,4,5,5a,7,8,9,9b-octahydro-3H-benzo[g][2]benzofuran-1-one	Investigative	137642658	C27H30FNO3	435.5	C[C@@]12CC[C@H]([C@@]([C@H]1CC[C@H]3[C@H]2C(=O)OC3)(C)/C=C/C4=NC=C(C=C4)C5=CC(=CC=C5)F)O	IC50 ~ 100000 nM	Poor binder
T36483	Proteinase activated receptor 1	BLN2J8	(2S)-5-[[(2S)-2-[Acetyl-[(E)-3-phenylprop-2-enoyl]amino]-3-(4-fluorophenyl)propanoyl]carbamoylamino]-2-[[(2S)-2-[[(2S)-2-amino-5-(diaminomethylideneamino)pentanoyl]amino]-4-methylpentanoyl]amino]pentanoic acid	Investigative	90663347	C38H52FN9O8	781.9	CC(C)C[C@@H](C(=O)N[C@@H](CCCNC(=O)NC(=O)[C@H](CC1=CC=C(C=C1)F)N(C(=O)C)C(=O)/C=C/C2=CC=CC=C2)C(=O)O)NC(=O)[C@H](CCCN=C(N)N)N	EC50 = 67000 nM	Poor binder
T36483	Proteinase activated receptor 1	BLQG91	[(3As,5aS,6R,7R,9aR,9bR)-6-[(E)-2-[5-(3-fluorophenyl)pyridin-2-yl]ethenyl]-6,9a-dimethyl-1-oxo-3a,4,5,5a,7,8,9,9b-octahydro-3H-benzo[e][2]benzofuran-7-yl] acetate	Investigative	137648050	C29H32FNO4	477.6	CC(=O)O[C@@H]1CC[C@@]2([C@@H]([C@@]1(C)/C=C/C3=NC=C(C=C3)C4=CC(=CC=C4)F)CC[C@H]5[C@H]2C(=O)OC5)C	IC50 ~ 100000 nM	Poor binder
T36483	Proteinase activated receptor 1	BN0EY1	N-[(2S)-6-Amino-1-[[(2S)-5-(diaminomethylideneamino)-1-oxo-1-(2-phenylethylamino)pentan-2-yl]amino]-1-oxohexan-2-yl]-2-[(1S)-2-(4-fluorophenyl)-1-[[2-(methylamino)acetyl]amino]ethyl]-1,3-thiazole-4-carboxamide	Investigative	9896668	C35H49FN10O4S	724.9	CNCC(=O)N[C@@H](CC1=CC=C(C=C1)F)C2=NC(=CS2)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C(N)N)C(=O)NCCC3=CC=CC=C3	IC50 ~ 100000 nM	Poor binder
T36483	Proteinase activated receptor 1	BN3C1R	[(3As,5aS,6R,7R,9aR,9bR)-6-[(E)-2-[5-(3-fluorophenyl)pyridin-2-yl]ethenyl]-6,9a-dimethyl-1-oxo-3a,4,5,5a,7,8,9,9b-octahydro-3H-benzo[e][2]benzofuran-7-yl] butanoate	Investigative	137657357	C31H36FNO4	505.6	CCCC(=O)O[C@@H]1CC[C@@]2([C@@H]([C@@]1(C)/C=C/C3=NC=C(C=C3)C4=CC(=CC=C4)F)CC[C@H]5[C@H]2C(=O)OC5)C	IC50 ~ 100000 nM	Poor binder
T36483	Proteinase activated receptor 1	BN6TW2	(2S)-2-[[(2S)-2-[[(2S)-2-(N-Acetylanilino)-3-(4-fluorophenyl)propanoyl]amino]-3-[4-(diaminomethylideneamino)phenyl]propanoyl]amino]-N-[(2S)-1-amino-5-(diaminomethylideneamino)-1-oxopentan-2-yl]-4-methylpentanamide	Investigative	90663331	C39H52FN11O5	773.9	CC(C)C[C@@H](C(=O)N[C@@H](CCCN=C(N)N)C(=O)N)NC(=O)[C@H](CC1=CC=C(C=C1)N=C(N)N)NC(=O)[C@H](CC2=CC=C(C=C2)F)N(C3=CC=CC=C3)C(=O)C	IC50 = 94000 nM	Poor binder
T36483	Proteinase activated receptor 1	BN9W6D	(2S)-2-[[(2S)-2-[[(2S)-2-[Acetyl-[(E)-3-phenylprop-2-enoyl]amino]-3-(4-fluorophenyl)propanoyl]amino]-3-(4-aminophenyl)propanoyl]amino]-N-[(2S)-1-amino-5-(diaminomethylideneamino)-1-oxopentan-2-yl]-4-methylpentanamide	Investigative	90663300	C41H52FN9O6	785.9	CC(C)C[C@@H](C(=O)N[C@@H](CCCN=C(N)N)C(=O)N)NC(=O)[C@H](CC1=CC=C(C=C1)N)NC(=O)[C@H](CC2=CC=C(C=C2)F)N(C(=O)C)C(=O)/C=C/C3=CC=CC=C3	EC50 = 60000 nM	Poor binder
T36483	Proteinase activated receptor 1	BP76DM	(2S)-2-[[(2R)-2-[[(2S)-2-[Acetyl-[(E)-3-phenylprop-2-enoyl]amino]-3-(4-fluorophenyl)propanoyl]amino]-4-[bis(dimethylamino)methylideneamino]butanoyl]amino]-N-[(2S)-1-amino-5-(diaminomethylideneamino)-1-oxopentan-2-yl]-4-methylpentanamide	Investigative	90663317	C41H60FN11O6	822	CC(C)C[C@@H](C(=O)N[C@@H](CCCN=C(N)N)C(=O)N)NC(=O)[C@@H](CCN=C(N(C)C)N(C)C)NC(=O)[C@H](CC1=CC=C(C=C1)F)N(C(=O)C)C(=O)/C=C/C2=CC=CC=C2	IC50 = 140000 nM	Poor binder
T36483	Proteinase activated receptor 1	BQES04	(S)-2-[(S)-2-((S)-2-{(S)-2-[(S)-2-((S)-2-Amino-3-hydroxy-propionylamino)-3-phenyl-propionylamino]-4-methyl-pentanoylamino}-4-methyl-pentanoylamino)-5-guanidino-pentanoylamino]-succinamide	Investigative	10010285	C34H57N11O8	747.9	CC(C)C[C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CC(=O)N)C(=O)N)NC(=O)[C@H](CC1=CC=CC=C1)NC(=O)[C@H](CO)N	IC50 = 73000 nM	Poor binder
T36483	Proteinase activated receptor 1	BQF6Z2	(1S,2R,4As,5R,6S,8aS)-1,6-bis(1,3-dithiolan-2-yl)-5-[(E)-2-[5-(3-fluorophenyl)pyridin-2-yl]ethenyl]-1,4a-dimethyl-2,3,4,5,6,7,8,8a-octahydronaphthalen-2-ol	Investigative	137658217	C31H38FNOS4	587.9	C[C@@]12CC[C@H]([C@@]([C@H]1CC[C@@H]([C@H]2/C=C/C3=NC=C(C=C3)C4=CC(=CC=C4)F)C5SCCS5)(C)C6SCCS6)O	IC50 ~ 100000 nM	Poor binder
T36483	Proteinase activated receptor 1	BT92MQ	N-[(2S)-1-[[(2S)-1-(Benzylamino)-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-3-cyclohexyl-1-oxopropan-2-yl]-2-[(1S)-1-(2,3-diaminopropanoylamino)-2-(4-fluorophenyl)ethyl]-5-methyl-1,3-oxazole-4-carboxamide	Investigative	44290276	C38H53FN10O5	748.9	CC1=C(N=C(O1)[C@H](CC2=CC=C(C=C2)F)NC(=O)C(CN)N)C(=O)N[C@@H](CC3CCCCC3)C(=O)N[C@@H](CCCN=C(N)N)C(=O)NCC4=CC=CC=C4	IC50 = 53000 nM	Poor binder
T36483	Proteinase activated receptor 1	BTBM52	Methyl (1S,2R,4aR,5S,6S,8aS)-2-acetyloxy-5-[(E)-2-[5-(3-fluorophenyl)pyridin-2-yl]ethenyl]-1,4a-dimethylspiro[3,4,5,7,8,8a-hexahydro-2H-naphthalene-6,2'-oxirane]-1-carboxylate	Investigative	137653221	C30H34FNO5	507.6	CC(=O)O[C@@H]1CC[C@@]2([C@@H]([C@]1(C)C(=O)OC)CC[C@]3([C@H]2/C=C/C4=NC=C(C=C4)C5=CC(=CC=C5)F)CO3)C	IC50 ~ 100000 nM	Poor binder
T36483	Proteinase activated receptor 1	BTXN37	(2S)-2-[[(2S)-2-[[2-[Acetyl-[(E)-3-phenylprop-2-enoyl]amino]acetyl]amino]-3-[4-(diaminomethylideneamino)phenyl]propanoyl]amino]-N-[(2S)-1-amino-5-(diaminomethylideneamino)-1-oxopentan-2-yl]-4-methylpentanamide	Investigative	90663323	C35H49N11O6	719.8	CC(C)C[C@@H](C(=O)N[C@@H](CCCN=C(N)N)C(=O)N)NC(=O)[C@H](CC1=CC=C(C=C1)N=C(N)N)NC(=O)CN(C(=O)C)C(=O)/C=C/C2=CC=CC=C2	IC50 ~ 100000 nM	Poor binder
T36483	Proteinase activated receptor 1	BU0E3A	L-Alaninamide, L-seryl-L-phenylalanyl-L-leucyl-L-leucyl-	Investigative	10325208	C27H44N6O6	548.7	C[C@@H](C(=O)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC1=CC=CC=C1)NC(=O)[C@H](CO)N	EC50 = 70000 nM	Poor binder
T36483	Proteinase activated receptor 1	BU1CX6	[(2R,4As,5S,6S,8aS)-5-[(E)-2-[5-(3-fluorophenyl)pyridin-2-yl]ethenyl]-1,1,4a,6-tetramethyl-2,3,4,5,6,7,8,8a-octahydronaphthalen-2-yl] butanoate	Investigative	137643571	C31H40FNO2	477.7	CCCC(=O)O[C@@H]1CC[C@@]2([C@@H](C1(C)C)CC[C@@H]([C@H]2/C=C/C3=NC=C(C=C3)C4=CC(=CC=C4)F)C)C	IC50 ~ 100000 nM	Poor binder
T36483	Proteinase activated receptor 1	BU3Y5S	(1S,2S,4As,5R,6R,8aR)-1-[(E)-2-[5-(3-fluorophenyl)pyridin-2-yl]ethenyl]-5-(hydroxymethyl)-2,5,8a-trimethyl-3,4,4a,6,7,8-hexahydro-1H-naphthalene-2,6-diol	Investigative	137644873	C27H34FNO3	439.6	C[C@@]12CC[C@H]([C@@]([C@H]1CC[C@]([C@H]2/C=C/C3=NC=C(C=C3)C4=CC(=CC=C4)F)(C)O)(C)CO)O	IC50 = 55000 nM	Poor binder
T36483	Proteinase activated receptor 1	BUK32R	(2S)-2-[[(2S)-2-[[(2S)-2-[Acetyl(thiophen-3-yl)amino]-3-(4-fluorophenyl)propanoyl]amino]-3-[4-(diaminomethylideneamino)phenyl]propanoyl]amino]-N-[(2S)-1-amino-5-(diaminomethylideneamino)-1-oxopentan-2-yl]-4-methylpentanamide	Investigative	90663340	C37H50FN11O5S	779.9	CC(C)C[C@@H](C(=O)N[C@@H](CCCN=C(N)N)C(=O)N)NC(=O)[C@H](CC1=CC=C(C=C1)N=C(N)N)NC(=O)[C@H](CC2=CC=C(C=C2)F)N(C3=CSC=C3)C(=O)C	IC50 = 74000 nM	Poor binder
T36483	Proteinase activated receptor 1	BV9J5C	(2S)-2-[[(2S)-2-[[(2S)-2-[Acetyl-[(E)-3-phenylprop-2-enoyl]amino]-3-(4-fluorophenyl)propanoyl]amino]-3-[4-(diaminomethylideneamino)phenyl]propanoyl]amino]-5-aminopentanamide	Investigative	90663296	C35H41FN8O5	672.7	CC(=O)N([C@@H](CC1=CC=C(C=C1)F)C(=O)N[C@@H](CC2=CC=C(C=C2)N=C(N)N)C(=O)N[C@@H](CCCN)C(=O)N)C(=O)/C=C/C3=CC=CC=C3	IC50 = 141000 nM	Poor binder
T36483	Proteinase activated receptor 1	BVJT12	(2R)-2-[[(2S)-2-[Acetyl-[(E)-3-phenylprop-2-enoyl]amino]-3-(4-fluorophenyl)propanoyl]amino]-N-[(2S)-1-[[(2S)-1-amino-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]-6-[bis(dimethylamino)methylideneamino]hexanamide	Investigative	90663321	C43H64FN11O6	850	CC(C)C[C@@H](C(=O)N[C@@H](CCCN=C(N)N)C(=O)N)NC(=O)[C@@H](CCCCN=C(N(C)C)N(C)C)NC(=O)[C@H](CC1=CC=C(C=C1)F)N(C(=O)C)C(=O)/C=C/C2=CC=CC=C2	IC50 = 90000 nM	Poor binder
T36483	Proteinase activated receptor 1	BW5T4J	(2S)-2-[[(2S)-2-[[(2S)-2-[Acetyl-[(E)-3-phenylprop-2-enoyl]amino]-3-(4-fluorophenyl)propanoyl]amino]-3-pyridin-3-ylpropanoyl]amino]-N-[(2S)-1-amino-5-(diaminomethylideneamino)-1-oxopentan-2-yl]-4-methylpentanamide	Investigative	90663350	C40H50FN9O6	771.9	CC(C)C[C@@H](C(=O)N[C@@H](CCCN=C(N)N)C(=O)N)NC(=O)[C@H](CC1=CN=CC=C1)NC(=O)[C@H](CC2=CC=C(C=C2)F)N(C(=O)C)C(=O)/C=C/C3=CC=CC=C3	EC50 = 116000 nM	Poor binder
T36483	Proteinase activated receptor 1	BW78CD	Chembl4226195	Investigative	145971090	C17H17N5O2	323.35	CCCC(=O)NC1=CC(=CC=C1)NC(=O)C2=CC=CC=C2N=[N+]=[N-]	IC50 = 94000 nM	Poor binder
T36483	Proteinase activated receptor 1	BX56EP	N-[(2R)-1-[[(2S)-1-[[(2S)-1-Amino-1-oxo-3-phenylpropan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-3-cyclohexyl-1-oxopropan-2-yl]-2-[(1S)-2-(4-fluorophenyl)-1-[[2-(methylamino)acetyl]amino]ethyl]-1,3-thiazole-4-carboxamide	Investigative	44290251	C39H53FN10O5S	793	CNCC(=O)N[C@@H](CC1=CC=C(C=C1)F)C2=NC(=CS2)C(=O)N[C@H](CC3CCCCC3)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CC4=CC=CC=C4)C(=O)N	IC50 = 94000 nM	Poor binder
T36483	Proteinase activated receptor 1	BY0T8N	N-[(2S)-1-[[(2S)-1-[[(2S)-1-Amino-1-oxo-3-phenylpropan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]-2-[(1S)-2-(4-fluorophenyl)-1-[[2-(methylamino)acetyl]amino]ethyl]-1,3-thiazole-4-carboxamide	Investigative	44289942	C36H50FN13O5S	795.9	CNCC(=O)N[C@@H](CC1=CC=C(C=C1)F)C2=NC(=CS2)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CC3=CC=CC=C3)C(=O)N	IC50 ~ 100000 nM	Poor binder