TTD_Target_ID	Target_Name	TTD_Drug_ID	Drug_Name	Drug_Highest_Status	Drug_PubchemID	Molecular_Formula	Molecular_Weight	Canonical_SMILES	Activity	Binder_Type
T40332	Neutrophil elastase	D0V3YT	BOCEPREVIR	Approved	10324367	C27H45N5O5	519.7	CC1([C@@H]2[C@H]1[C@H](N(C2)C(=O)[C@H](C(C)(C)C)NC(=O)NC(C)(C)C)C(=O)NC(CC3CCC3)C(=O)C(=O)N)C	IC50 ~ 100000 nM	Poor binder
T40332	Neutrophil elastase	D0A5BT	Camostat mesylate	Phase 2/3	5284360	C21H26N4O8S	494.5	CN(C)C(=O)COC(=O)CC1=CC=C(C=C1)OC(=O)C2=CC=C(C=C2)N=C(N)N.CS(=O)(=O)O	IC50 ~ 100000 nM	Poor binder
T40332	Neutrophil elastase	B01IJQ	[(S)-1-((2S,3S)-2-Tert-Butoxy-4-oxo-azetidin-3-ylcarbamoyl)-2-phenyl-ethyl]-carbamic acid benzyl ester	Investigative	18395047	C24H29N3O5	439.5	CC(C)(C)O[C@H]1[C@@H](C(=O)N1)NC(=O)[C@H](CC2=CC=CC=C2)NC(=O)OCC3=CC=CC=C3	IC50 ~ 50000 nM	Poor binder
T40332	Neutrophil elastase	B0EV4J	2-Oxo-4-phenacylsulfanyl-N-[(1R)-1-phenylethyl]azetidine-1-carboxamide	Investigative	482288	C20H20N2O3S	368.5	C[C@H](C1=CC=CC=C1)NC(=O)N2C(CC2=O)SCC(=O)C3=CC=CC=C3	IC50 ~ 75000 nM	Poor binder
T40332	Neutrophil elastase	B0FT8Z	(3S,4S)-1,4-Diacetyl-3-methoxy-azetidin-2-one	Investigative	44319384	C8H11NO4	185.18	CC(=O)[C@@H]1[C@@H](C(=O)N1C(=O)C)OC	IC50 = 94000 nM	Poor binder
T40332	Neutrophil elastase	B0FUD5	2-({5-[(1,3-Benzothiazol-2-ylsulfanyl)methyl]-4-phenyl-4H-1,2,4-triazol-3-yl}sulfanyl)acetic acid	Investigative	2372853	C18H14N4O2S3	414.5	C1=CC=C(C=C1)N2C(=NN=C2SCC(=O)O)CSC3=NC4=CC=CC=C4S3	IC50 ~ 100000 nM	Poor binder
T40332	Neutrophil elastase	B0UV3N	(4S)-4-Methoxy-6,6-dioxo-10-oxa-6lambda6-thia-2-azatricyclo[6.3.0.02,5]undec-1(8)-ene-3,11-dione	Investigative	14760380	C9H9NO6S	259.24	CO[C@@H]1C2N(C1=O)C3=C(COC3=O)CS2(=O)=O	IC50 = 57800 nM	Poor binder
T40332	Neutrophil elastase	B0XEY2	Met-Phe-Leu-Glu-Ala-Ile-Pro-Met-Ser	Investigative	44273766	C47H75N9O13S2	1038.3	CC[C@@H](C)[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CO)C(=O)O)NC(=O)[C@@H](C)NC(=O)[C@@H](CCC(=O)O)NC(=O)[C@@H](CC(C)C)NC(=O)[C@@H](CC2=CC=CC=C2)NC(=O)[C@@H](CCSC)N	Ki = 190000 nM	Poor binder
T40332	Neutrophil elastase	B0Z8AI	N-((1S)-2-Hydroxy-1-phenylethyl)[2-oxo-4-(2-pyridylmethylthio)azetidinyl]carboxamide	Investigative	482292	C18H19N3O3S	357.4	C1C(N(C1=O)C(=O)N[C@H](CO)C2=CC=CC=C2)SCC3=CC=CC=N3	IC50 ~ 75000 nM	Poor binder
T40332	Neutrophil elastase	B1SPU6	(4R)-4-[[(2S)-2-Acetamido-3-carboxypropanoyl]amino]-5-[[(2S,3S)-3-methyl-1-[[(2S)-3-methyl-1-oxo-1-[(2S,4R)-2-[[pentyl-[[(1S)-1-phenylethyl]carbamoyl]amino]carbamoyl]-4-phenylmethoxypyrrolidin-1-yl]butan-2-yl]amino]-1-oxopentan-2-yl]amino]-5-oxopentanoic acid	Investigative	644155	C48H70N8O12	951.1	CCCCCN(C(=O)N[C@@H](C)C1=CC=CC=C1)NC(=O)[C@@H]2C[C@H](CN2C(=O)[C@H](C(C)C)NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@@H](CCC(=O)O)NC(=O)[C@H](CC(=O)O)NC(=O)C)OCC3=CC=CC=C3	IC50 = 151000 nM	Poor binder
T40332	Neutrophil elastase	B1TMI4	(S)-2-Benzyl-4-oxo-azetidine-1-carboxylic acid (pyridin-4-ylmethyl)-amide	Investigative	10756289	C17H17N3O2	295.34	C1[C@@H](N(C1=O)C(=O)NCC2=CC=NC=C2)CC3=CC=CC=C3	IC50 ~ 75000 nM	Poor binder
T40332	Neutrophil elastase	B23VKE	2-(4-Fluoroanilino)-5H-[1,3]thiazino[5,4-b]indol-4-one	Investigative	44317285	C16H10FN3OS	311.3	C1=CC=C2C(=C1)C3=C(N2)C(=O)SC(=N3)NC4=CC=C(C=C4)F	Ki ~ 104000 nM	Poor binder
T40332	Neutrophil elastase	B23YKO	2-[5-(2-Methyl-furan-3-yl)-4-(1-phenyl-ethyl)-4H-[1,2,4]triazol-3-ylsulfanyl]-N-phenethyl-acetamide	Investigative	644930	C25H26N4O2S	446.6	CC1=C(C=CO1)C2=NN=C(N2C(C)C3=CC=CC=C3)SCC(=O)NCCC4=CC=CC=C4	IC50 ~ 100000 nM	Poor binder
T40332	Neutrophil elastase	B26TUB	[(S)-1-((3R,4S)-2-Oxo-4-phenylsulfanyl-azetidin-3-ylcarbamoyl)-2-phenyl-ethyl]-carbamic acid benzyl ester	Investigative	10457653	C26H25N3O4S	475.6	C1=CC=C(C=C1)C[C@@H](C(=O)N[C@H]2[C@@H](NC2=O)SC3=CC=CC=C3)NC(=O)OCC4=CC=CC=C4	IC50 ~ 50000 nM	Poor binder
T40332	Neutrophil elastase	B29LPH	2-(2,3,4,5,6-Pentafluorophenyl)-4,5,6,7-tetrahydro-1,2-benzisothiazol-3(2H)-one 1,1-dioxide	Investigative	44561932	C13H8F5NO3S	353.27	C1CCC2=C(C1)C(=O)N(S2(=O)=O)C3=C(C(=C(C(=C3F)F)F)F)F	IC50 ~ 100000 nM	Poor binder
T40332	Neutrophil elastase	B2GAY6	Tert-butyl (2E)-2-[(5S,6R)-6-[(1R)-1-hydroxyethyl]-7-oxo-2,4-dithia-1-azabicyclo[3.2.0]heptan-3-ylidene]acetate	Investigative	44312600	C12H17NO4S2	303.4	C[C@H]([C@H]1[C@H]2N(C1=O)S/C(=C/C(=O)OC(C)(C)C)/S2)O	Ki ~ 100000 nM	Poor binder
T40332	Neutrophil elastase	B2K3UI	3-[(3-Acetoxymethyl-7-methoxy-5,5,8-trioxo-5lambda*6*-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carbonyl)-amino]-propionic acid	Investigative	14760306	C14H18N2O9S	390.37	CC(=O)OCC1=C(N2[C@@H]([C@H](C2=O)OC)S(=O)(=O)C1)C(=O)NCCC(=O)O	IC50 ~ 50000 nM	Poor binder
T40332	Neutrophil elastase	B2MZQ5	[(3-Acetoxymethyl-7-methoxy-5,5,8-trioxo-5lambda*6*-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carbonyl)-amino]-acetic acid	Investigative	14760308	C13H16N2O9S	376.34	CC(=O)OCC1=C(N2[C@@H]([C@H](C2=O)OC)S(=O)(=O)C1)C(=O)NCC(=O)O	IC50 ~ 50000 nM	Poor binder
T40332	Neutrophil elastase	B2OHL3	3-[(1-{2-[(1-Acetyl-pyrrolidine-2-carbonyl)-amino]-propionyl}-pyrrolidine-2-carbonyl)-amino]-2-oxo-butyric acid	Investigative	44353364	C19H28N4O7	424.4	C[C@@H](C(=O)C(=O)O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](C)NC(=O)[C@@H]2CCCN2C(=O)C	Ki = 66000 nM	Poor binder
T40332	Neutrophil elastase	B2RNQ7	2-[4-(4-Methoxyphenyl)-5-(2-naphthyloxymethyl)-1,2,4-triazol-3-ylthio]acetic a cid	Investigative	1169805	C22H19N3O4S	421.5	COC1=CC=C(C=C1)N2C(=NN=C2SCC(=O)O)COC3=CC4=CC=CC=C4C=C3	IC50 ~ 100000 nM	Poor binder
T40332	Neutrophil elastase	B30API	(2S)-N-[(1S)-3-Methyl-1-({4-oxo-1-[N-benzylcarbamoyl]azetidin-2-yloxy}methyl)butyl]-2-[(tert-butoxy)carbonylamino]-3,3-dimethylbutanamide	Investigative	482277	C28H44N4O6	532.7	CC(C)C[C@@H](COC1CC(=O)N1C(=O)NCC2=CC=CC=C2)NC(=O)[C@H](C(C)(C)C)NC(=O)OC(C)(C)C	IC50 ~ 75000 nM	Poor binder
T40332	Neutrophil elastase	B30PIA	Tomentin D	Investigative	71659766	C27H34O8	486.6	CC1(CCC2=C(C3=C(C=C2O1)O[C@@H](CC3=O)C4=CC(=C(C(=C4)OC)O)OC)O)CCCC(C)(C)O	IC50 ~ 100000 nM	Poor binder
T40332	Neutrophil elastase	B32RZV	[4-[[2-[(E)-N-(3-Hydroxypropoxy)-C-methylcarbonimidoyl]phenyl]sulfamoyl]phenyl] 2,2-dimethylpropanoate	Investigative	118010070	C22H28N2O6S	448.5	C/C(=N\\OCCCO)/C1=CC=CC=C1NS(=O)(=O)C2=CC=C(C=C2)OC(=O)C(C)(C)C	IC50 = 158800 nM	Poor binder
T40332	Neutrophil elastase	B35VJP	E-6-O-p-Feruloyl scandoside methyl ester	Investigative	46225505	C27H32O14	580.5	COC1=C(C=CC(=C1)/C=C/C(=O)O[C@@H]2C=C([C@@H]3[C@H]2C(=CO[C@H]3O[C@H]4[C@@H]([C@H]([C@@H]([C@H](O4)CO)O)O)O)C(=O)OC)CO)O	IC50 ~ 100000 nM	Poor binder
T40332	Neutrophil elastase	B36ZIR	2-(6-Bromopyridin-2-yl)-4,5,6,7-tetrahydro-1,2-benzisothiazol-3(2H)-one 1,1-dioxide	Investigative	44561892	C12H11BrN2O3S	343.2	C1CCC2=C(C1)C(=O)N(S2(=O)=O)C3=NC(=CC=C3)Br	IC50 ~ 100000 nM	Poor binder
T40332	Neutrophil elastase	B3KHJ2	3-Acetoxymethyl-7-methoxy-5,5,8-trioxo-5lambda*6*-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid	Investigative	10087296	C11H13NO8S	319.29	CC(=O)OCC1=C(N2[C@@H]([C@H](C2=O)OC)S(=O)(=O)C1)C(=O)O	IC50 ~ 50000 nM	Poor binder
T40332	Neutrophil elastase	B3KYM0	4,5-Dimethyl-2-(2,3,5,6-tetrafluoropyridin-4-yl)-isothiazol-3(2H)-one 1,1-dioxide	Investigative	44561930	C10H6F4N2O3S	310.23	CC1=C(S(=O)(=O)N(C1=O)C2=C(C(=NC(=C2F)F)F)F)C	IC50 ~ 100000 nM	Poor binder
T40332	Neutrophil elastase	B47CTI	(3As,6R)-6-Allyl-4-(naphthalene-1-sulfonyl)-5-oxo-hexahydro-pyrrolo[3,2-b]pyrrole-1-carboxylic acid benzyl ester	Investigative	44351162	C27H26N2O5S	490.6	C=CC[C@@H]1C2[C@H](CCN2C(=O)OCC3=CC=CC=C3)N(C1=O)S(=O)(=O)C4=CC=CC5=CC=CC=C54	IC50 ~ 100000 nM	Poor binder
T40332	Neutrophil elastase	B4A0SE	4-(2-{2-[2-(4-Carboxy-2-isobutoxycarbonylamino-butyrylamino)-4-methyl-pentanoylamino]-4,4-difluoro-butyrylamino}-ethyl)-3-chloro-benzoic acid	Investigative	44343906	C29H41ClF2N4O9	663.1	CC(C)C[C@@H](C(=O)NC(CC(F)F)C(=O)NCCC1=C(C=C(C=C1)C(=O)O)Cl)NC(=O)C(CCC(=O)O)NC(=O)OCC(C)C	Ki ~ 100000 nM	Poor binder
T40332	Neutrophil elastase	B4DRN9	Chembl4175745	Investigative	86268083	C25H30O6	426.5	C/C(=C\\CC1=C(C2=C(C=C1O)O[C@@H](CC2=O)C3=CC=C(C=C3)O)O)/CCCC(C)(C)O	IC50 = 74700 nM	Poor binder
T40332	Neutrophil elastase	B4GB9S	((S)-1-{(S)-2-[(S)-1-(3-Ethoxy-pyridine-2-carbonyl)-2-methyl-propylcarbamoyl]-pyrrolidine-1-carbonyl}-2-methyl-propyl)-carbamic acid benzyl ester	Investigative	10076315	C30H40N4O6	552.7	CCOC1=C(N=CC=C1)C(=O)[C@H](C(C)C)NC(=O)[C@@H]2CCCN2C(=O)[C@H](C(C)C)NC(=O)OCC3=CC=CC=C3	Ki = 87000 nM	Poor binder
T40332	Neutrophil elastase	B4M8LQ	4-{5-[(Z)-(5-Cyano-2-hydroxy-4-methyl-6-oxopyridin-3(6H)-ylidene)methyl]furan-2-yl}benzenesulfonamide	Investigative	2264784	C18H13N3O5S	383.4	CC\\1=C(C(=O)NC(=O)/C1=C\\C2=CC=C(O2)C3=CC=C(C=C3)S(=O)(=O)N)C#N	IC50 = 52200 nM	Poor binder
T40332	Neutrophil elastase	B5DS1I	(5-Hydroxy-4-oxo-4h-pyran-2-yl)methyl hexadecanoate	Investigative	223062	C22H36O5	380.5	CCCCCCCCCCCCCCCC(=O)OCC1=CC(=O)C(=CO1)O	IC50 = 100000 nM	Poor binder
T40332	Neutrophil elastase	B5QXT8	4-((R)-1-((R)-6-(5-Chloro-2-methoxybenzyl)-2,5-dioxo-1,4-diazepane-4-carboxamido)propyl)-2-aminobenzoic acid	Investigative	11540629	C24H27ClN4O6	502.9	CC[C@H](C1=CC(=C(C=C1)C(=O)O)N)NC(=O)N2CC(=O)NC[C@H](C2=O)CC3=C(C=CC(=C3)Cl)OC	IC50 = 100000 nM	Poor binder
T40332	Neutrophil elastase	B6IC7R	[(S)-1-((2S,3S)-2-Isobutoxy-4-oxo-azetidin-3-ylcarbamoyl)-2-phenyl-ethyl]-carbamic acid benzyl ester	Investigative	18395048	C24H29N3O5	439.5	CC(C)CO[C@H]1[C@@H](C(=O)N1)NC(=O)[C@H](CC2=CC=CC=C2)NC(=O)OCC3=CC=CC=C3	IC50 ~ 50000 nM	Poor binder
T40332	Neutrophil elastase	B6JPV8	N-((1R)-1-Phenylethyl)[2-oxo-4-(2-pyridylmethylthio)azetidinyl]carboxamide	Investigative	482287	C18H19N3O2S	341.4	C[C@H](C1=CC=CC=C1)NC(=O)N2C(CC2=O)SCC3=CC=CC=N3	IC50 ~ 75000 nM	Poor binder
T40332	Neutrophil elastase	B6L2WG	Adamantane-1-carboxylic acid 6-octadec-9-enoyloxymethyl-4-oxo-4H-pyran-3-yl ester	Investigative	14089184	C35H52O6	568.8	CCCCCCCC/C=C/CCCCCCCC(=O)OCC1=CC(=O)C(=CO1)OC(=O)C23CC4CC(C2)CC(C4)C3	IC50 = 80000 nM	Poor binder
T40332	Neutrophil elastase	B6MN7T	2-Chloro-5-[(4Z)-4-[[5-(4-chlorophenyl)furan-2-yl]methylidene]-3,5-dioxopyrazolidin-1-yl]benzoic acid	Investigative	44415189	C21H12Cl2N2O5	443.2	C1=CC(=CC=C1C2=CC=C(O2)/C=C\\3/C(=O)NN(C3=O)C4=CC(=C(C=C4)Cl)C(=O)O)Cl	IC50 = 89800 nM	Poor binder
T40332	Neutrophil elastase	B6NB3X	(4-Carbamimidoylphenyl) 4-[(E)-3-[(2-ethoxy-2-oxoethyl)-prop-2-enylamino]-2-methyl-3-oxoprop-1-enyl]benzoate;methanesulfonic acid	Investigative	6442224	C26H31N3O8S	545.6	CCOC(=O)CN(CC=C)C(=O)/C(=C/C1=CC=C(C=C1)C(=O)OC2=CC=C(C=C2)C(=N)N)/C.CS(=O)(=O)O	IC50 ~ 100000 nM	Poor binder
T40332	Neutrophil elastase	B6NP8K	(9-Benzyl-2,4-dioxo-1H-[1,3]oxazino[4,5-b]indol-6-yl) acetate	Investigative	10665528	C19H14N2O5	350.3	CC(=O)OC1=CC2=C(C=C1)N(C3=C2C(=O)OC(=O)N3)CC4=CC=CC=C4	IC50 = 75000 nM	Poor binder
T40332	Neutrophil elastase	B6PSY3	4-(4-Guanidinobenzoyloxy)phenylacetic acid	Investigative	130394	C17H19N3O7S	409.4	CS(=O)(=O)O.C1=CC(=CC=C1CC(=O)O)OC(=O)C2=CC=C(C=C2)N=C(N)N	IC50 ~ 100000 nM	Poor binder
T40332	Neutrophil elastase	B6S2QZ	2-(4-Methylanilino)-5H-[1,3]thiazino[5,4-b]indol-4-one	Investigative	44317274	C17H13N3OS	307.4	CC1=CC=C(C=C1)NC2=NC3=C(C(=O)S2)NC4=CC=CC=C43	Ki ~ 78000 nM	Poor binder
T40332	Neutrophil elastase	B7AY1W	[(S)-1-((3R,4R)-2-Oxo-4-phenylsulfanyl-azetidin-3-ylcarbamoyl)-2-phenyl-ethyl]-carbamic acid benzyl ester	Investigative	44279475	C26H25N3O4S	475.6	C1=CC=C(C=C1)C[C@@H](C(=O)N[C@H]2[C@H](NC2=O)SC3=CC=CC=C3)NC(=O)OCC4=CC=CC=C4	IC50 ~ 50000 nM	Poor binder
T40332	Neutrophil elastase	B7PJ2X	4-(1-{1-[2-(2-Chloro-phenyl)-ethylcarbamoyl]-2-mercapto-ethylcarbamoyl}-3-methyl-butylcarbamoyl)-4-isobutoxycarbonylamino-butyric acid	Investigative	44343907	C28H41ClF2N4O7	619.1	CC(C)C[C@@H](C(=O)NC(CC(F)F)C(=O)NCCC1=CC=CC=C1Cl)NC(=O)C(CCC(=O)O)NC(=O)OC(C)(C)C	Ki ~ 100000 nM	Poor binder
T40332	Neutrophil elastase	B7PMG1	2-(6-Chloropyridin-2-yl)-4,5,6,7-tetrahydro-1,2-benzisothiazol-3(2H)-one 1,1-dioxide	Investigative	44561891	C12H11ClN2O3S	298.75	C1CCC2=C(C1)C(=O)N(S2(=O)=O)C3=NC(=CC=C3)Cl	IC50 ~ 100000 nM	Poor binder
T40332	Neutrophil elastase	B7QLA0	[(S)-1-((R)-2-Oxo-azetidin-3-ylcarbamoyl)-2-phenyl-ethyl]-carbamic acid benzyl ester	Investigative	44279873	C20H21N3O4	367.4	C1[C@H](C(=O)N1)NC(=O)[C@H](CC2=CC=CC=C2)NC(=O)OCC3=CC=CC=C3	IC50 ~ 50000 nM	Poor binder
T40332	Neutrophil elastase	B7U1TP	4-(3,3-Diethyl-2,4-dioxoazetidin-1-yl)benzonitrile	Investigative	24823609	C14H14N2O2	242.27	CCC1(C(=O)N(C1=O)C2=CC=C(C=C2)C#N)CC	Ki = 63500 nM	Poor binder
T40332	Neutrophil elastase	B7WK2D	N-((1R)-1-Phenylpropyl)[2-oxo-4-(2-pyridylmethylthio)azetidinyl]carboxamide	Investigative	482290	C19H21N3O2S	355.5	CC[C@H](C1=CC=CC=C1)NC(=O)N2C(CC2=O)SCC3=CC=CC=N3	IC50 ~ 75000 nM	Poor binder
T40332	Neutrophil elastase	B7YB3K	Benzyl 2-[[2-(1-aminopropyl)-1,3-oxazole-4-carbonyl]amino]-3-phenylpropanoate	Investigative	3435549	C23H25N3O4	407.5	CCC(C1=NC(=CO1)C(=O)NC(CC2=CC=CC=C2)C(=O)OCC3=CC=CC=C3)N	IC50 ~ 100000 nM	Poor binder
T40332	Neutrophil elastase	B89CMZ	{[(2S,5R,6R)-3,3-Dimethyl-4,4,7-trioxo-6-(2,2,2-trifluoro-acetylamino)-4lambda*6*-thia-1-aza-bicyclo[3.2.0]heptane-2-carbonyl]-methyl-amino}-acetic acid	Investigative	44313122	C13H16F3N3O7S	415.34	CC1([C@@H](N2[C@H](S1(=O)=O)[C@@H](C2=O)NC(=O)C(F)(F)F)C(=O)N(C)CC(=O)O)C	Ki = 50000 nM	Poor binder
T40332	Neutrophil elastase	B8PY5V	(5Z)-5-[(2,4-Dihydroxyphenyl)methylidene]-2-sulfanylideneimidazolidin-4-one	Investigative	7028541	C10H8N2O3S	236.25	C1=CC(=C(C=C1O)O)/C=C\\2/C(=O)NC(=S)N2	IC50 = 84800 nM	Poor binder
T40332	Neutrophil elastase	B8RS5T	1,1-Dioxo-2-pyridin-4-yl-4,5,6,7-tetrahydro-1,2-benzothiazol-3-one;perchloric acid	Investigative	49797481	C12H13ClN2O7S	364.76	C1CCC2=C(C1)C(=O)N(S2(=O)=O)C3=CC=NC=C3.OCl(=O)(=O)=O	IC50 ~ 100000 nM	Poor binder
T40332	Neutrophil elastase	B8V7JZ	N1-(3,4-Dimethoxyphenethyl)-2-phenyl-2-(2-pyridylthio)acetamide	Investigative	433517	C23H24N2O3S	408.5	COC1=C(C=C(C=C1)CCNC(=O)C(C2=CC=CC=C2)SC3=CC=CC=N3)OC	IC50 ~ 100000 nM	Poor binder
T40332	Neutrophil elastase	B8X1PH	Methyl 2-{[2-(1H-1,3-benzimidazol-2-ylsulfanyl)acetyl]amino}-3-(benzylsulfanyl)propanoate	Investigative	5294946	C20H21N3O3S2	415.5	COC(=O)C(CSCC1=CC=CC=C1)NC(=O)CSC2=NC3=CC=CC=C3N2	IC50 ~ 100000 nM	Poor binder
T40332	Neutrophil elastase	B9RI7L	(2S)-2-Amino-N-[(1R,2R)-1-cyano-2-phenylcyclopropyl]-3-thiophen-2-ylpropanamide;2,2,2-trifluoroacetic acid	Investigative	49797573	C19H18F3N3O3S	425.4	C1[C@@H]([C@]1(C#N)NC(=O)[C@H](CC2=CC=CS2)N)C3=CC=CC=C3.C(=O)(C(F)(F)F)O	IC50 ~ 50000 nM	Poor binder
T40332	Neutrophil elastase	BA5VB4	(1R,2S)-1-[[(2S,4R)-1-[(2S)-2-(Tert-butoxycarbonylamino)-3,3-dimethyl-butanoyl]-4-[(7-methoxy-2-phenyl-4-quinolyl)oxy]pyrrolidine-2-carbonyl]amino]-2-vinyl-cyclopropanecarboxylic acid	Investigative	5271294	C38H46N4O8	686.8	CC(C)(C)[C@@H](C(=O)N1C[C@@H](C[C@H]1C(=O)N[C@@]2(C[C@H]2C=C)C(=O)O)OC3=CC(=NC4=C3C=CC(=C4)OC)C5=CC=CC=C5)NC(=O)OC(C)(C)C	IC50 ~ 75000 nM	Poor binder
T40332	Neutrophil elastase	BAQ8C7	2-[4-(4-Methoxyphenyl)-5-(2-naphthyloxymethyl)-1,2,4-triazol-3-ylthio]acetamid e	Investigative	1169804	C22H20N4O3S	420.5	COC1=CC=C(C=C1)N2C(=NN=C2SCC(=O)N)COC3=CC4=CC=CC=C4C=C3	IC50 ~ 100000 nM	Poor binder
T40332	Neutrophil elastase	BB3P4Z	4-(2,5-Dimethyl-1H-pyrrol-1-yl)-2-hydroxybenzoic acid	Investigative	668744	C13H13NO3	231.25	CC1=CC=C(N1C2=CC(=C(C=C2)C(=O)O)O)C	IC50 = 51500 nM	Poor binder
T40332	Neutrophil elastase	BB7OU5	N-((1R)-1-Phenylethyl)(2-oxo-4-phenylthioazetidinyl)carboxamide	Investigative	482282	C18H18N2O2S	326.4	C[C@H](C1=CC=CC=C1)NC(=O)N2C(CC2=O)SC3=CC=CC=C3	IC50 ~ 75000 nM	Poor binder
T40332	Neutrophil elastase	BC58XS	2-[(1R)-1-[[(6R)-6-[(5-Chloro-2-methoxyphenyl)methyl]-3,7-dioxo-1,4-diazepane-1-carbonyl]amino]propyl]-1,3-oxazole-4-carboxylic acid	Investigative	71723878	C21H23ClN4O7	478.9	CC[C@H](C1=NC(=CO1)C(=O)O)NC(=O)N2CC(=O)NC[C@H](C2=O)CC3=C(C=CC(=C3)Cl)OC	IC50 ~ 100000 nM	Poor binder
T40332	Neutrophil elastase	BC9L8Y	Tert-butyl (2E)-2-[(5R,6S)-6-[(1R)-1-hydroxyethyl]-7-oxo-1-azabicyclo[3.2.0]heptan-3-ylidene]acetate	Investigative	44312415	C14H21NO4	267.32	C[C@H]([C@@H]1[C@H]2C/C(=C\\C(=O)OC(C)(C)C)/CN2C1=O)O	Ki ~ 100000 nM	Poor binder
T40332	Neutrophil elastase	BC9M0N	N-((1R)-1-Phenylethyl)[2-oxo-4-(3-pyridylmethylthio)azetidinyl]carboxamide	Investigative	482286	C18H19N3O2S	341.4	C[C@H](C1=CC=CC=C1)NC(=O)N2C(CC2=O)SCC3=CN=CC=C3	IC50 ~ 75000 nM	Poor binder
T40332	Neutrophil elastase	BCHY67	1-Methoxy-2-methylanthracene-9,10-dione	Investigative	3534338	C16H12O3	252.26	CC1=C(C2=C(C=C1)C(=O)C3=CC=CC=C3C2=O)OC	IC50 ~ 60000 nM	Poor binder
T40332	Neutrophil elastase	BCMV20	Cambridge id 7076131	Investigative	1331170	C26H19N5O	417.5	C1=CC=C(C=C1)CNC(=O)C2=CC3=C(C=C2)N=C(C(=N3)C4=CC=CC=N4)C5=CC=CC=N5	IC50 ~ 100000 nM	Poor binder
T40332	Neutrophil elastase	BD32BG	2-Chloro-5-(2,5-dimethyl-pyrrol-1-yl)-benzoic acid	Investigative	776842	C13H12ClNO2	249.69	CC1=CC=C(N1C2=CC(=C(C=C2)Cl)C(=O)O)C	IC50 = 160200 nM	Poor binder
T40332	Neutrophil elastase	BDV09Q	2-(2-Fluoroanilino)-5H-[1,3]thiazino[5,4-b]indol-4-one	Investigative	44317137	C16H10FN3OS	311.3	C1=CC=C2C(=C1)C3=C(N2)C(=O)SC(=N3)NC4=CC=CC=C4F	Ki ~ 88000 nM	Poor binder
T40332	Neutrophil elastase	BDW2U3	(3,4,5-Trimethoxy-phenyl)-(3,4,5-trimethyl-pyrazol-1-yl)-methanone	Investigative	753830	C16H20N2O4	304.34	CC1=C(N(N=C1C)C(=O)C2=CC(=C(C(=C2)OC)OC)OC)C	Ki = 50900 nM	Poor binder
T40332	Neutrophil elastase	BE6S4C	Tert-butyl 2-[4-[[4-oxo-1-[[(1R)-1-phenylethyl]carbamoyl]azetidin-2-yl]sulfanylmethyl]phenyl]acetate	Investigative	482289	C25H30N2O4S	454.6	C[C@H](C1=CC=CC=C1)NC(=O)N2C(CC2=O)SCC3=CC=C(C=C3)CC(=O)OC(C)(C)C	IC50 ~ 75000 nM	Poor binder
T40332	Neutrophil elastase	BF7CZ9	4-(Morpholine-4-carbonyl)-N-{(R)-2-oxo-1-[(3,3,4,4,4-pentafluoro-1-isopropyl-2-oxo-butylcarbamoyl)-methyl]-piperidin-3-yl}-benzamide	Investigative	44461781	C26H31F5N4O6	590.5	CC(C)C(C(=O)C(C(F)(F)F)(F)F)NC(=O)CN1CCC[C@H](C1=O)NC(=O)C2=CC=C(C=C2)C(=O)N3CCOCC3	Ki = 95000 nM	Poor binder
T40332	Neutrophil elastase	BFC39R	6-O-Z-p-Methoxycinnamoyl scandoside methyl ester	Investigative	44584781	C27H32O13	564.5	COC1=CC=C(C=C1)/C=C\\C(=O)O[C@@H]2C=C([C@@H]3[C@H]2C(=CO[C@H]3O[C@H]4[C@@H]([C@H]([C@@H]([C@H](O4)CO)O)O)O)C(=O)OC)CO	IC50 ~ 100000 nM	Poor binder
T40332	Neutrophil elastase	BFX29D	3-Phenyl-propionic acid (2S,3S)-3-((S)-2-benzyloxycarbonylamino-3-phenyl-propionylamino)-4-oxo-azetidin-2-yl ester	Investigative	44280172	C29H29N3O6	515.6	C1=CC=C(C=C1)CCC(=O)O[C@H]2[C@@H](C(=O)N2)NC(=O)[C@H](CC3=CC=CC=C3)NC(=O)OCC4=CC=CC=C4	IC50 ~ 50000 nM	Poor binder
T40332	Neutrophil elastase	BG8V7H	4-((2R,3R)-1-Benzylcarbamoyl-3-methyl-4-oxo-3-propyl-azetidin-2-yloxy)-benzoic acid	Investigative	10363347	C22H24N2O5	396.4	CCC[C@@]1([C@H](N(C1=O)C(=O)NCC2=CC=CC=C2)OC3=CC=C(C=C3)C(=O)O)C	Ki = 51000 nM	Poor binder
T40332	Neutrophil elastase	BH01QX	[2,4-Dioxo-9-(2-phenylethyl)-1H-[1,3]oxazino[4,5-b]indol-6-yl] acetate	Investigative	44385622	C20H16N2O5	364.4	CC(=O)OC1=CC2=C(C=C1)N(C3=C2C(=O)OC(=O)N3)CCC4=CC=CC=C4	IC50 = 92000 nM	Poor binder
T40332	Neutrophil elastase	BH1A0P	{(S)-1-[(S)-1-((R)-2-{(S)-1-[(S)-1-((S)-1-Isopropylcarbamoyl-ethylcarbamoyl)-ethylcarbamoyl]-2-methyl-propylcarbamoyl}-pyrrolidin-1-ylcarbamoyl)-ethylcarbamoyl]-ethyl}-carbamic acid benzyl ester	Investigative	44363091	C33H52N8O8	688.8	C[C@@H](C(=O)NC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](C(C)C)NC(=O)[C@H]1CCCN1NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)OCC2=CC=CC=C2	Ki = 65000 nM	Poor binder
T40332	Neutrophil elastase	BH5SG9	[2-Oxo-4-(2-pyridylmethylthio)azetidinyl]-N-[2-(phenylmethoxy)ethyl]carboxamide	Investigative	482291	C19H21N3O3S	371.5	C1C(N(C1=O)C(=O)NCCOCC2=CC=CC=C2)SCC3=CC=CC=N3	IC50 ~ 75000 nM	Poor binder
T40332	Neutrophil elastase	BH87CS	Benzoic acid (2S,3S)-3-((S)-2-benzyloxycarbonylamino-3-phenyl-propionylamino)-4-oxo-azetidin-2-yl ester	Investigative	44280152	C27H25N3O6	487.5	C1=CC=C(C=C1)C[C@@H](C(=O)N[C@H]2[C@@H](NC2=O)OC(=O)C3=CC=CC=C3)NC(=O)OCC4=CC=CC=C4	IC50 ~ 50000 nM	Poor binder
T40332	Neutrophil elastase	BI2C3Y	{(S)-1-[(S)-1-(1-Benzylcarbamoyl-4-oxo-azetidin-2-ylsulfanylmethyl)-3-methyl-butylcarbamoyl]-2,2-dimethyl-propyl}-carbamic acid tert-butyl ester	Investigative	482280	C28H44N4O5S	548.7	CC(C)C[C@@H](CSC1CC(=O)N1C(=O)NCC2=CC=CC=C2)NC(=O)[C@H](C(C)(C)C)NC(=O)OC(C)(C)C	IC50 ~ 75000 nM	Poor binder
T40332	Neutrophil elastase	BI7MJ1	6-(3,5-Difluoroanilino)-9-(2,2-difluoroethyl)purine-2-carbonitrile	Investigative	44143089	C14H8F4N6	336.25	C1=C(C=C(C=C1F)F)NC2=C3C(=NC(=N2)C#N)N(C=N3)CC(F)F	IC50 = 85113.8 nM	Poor binder
T40332	Neutrophil elastase	BJ28MD	[4-(2,5-Dimethyl-pyrrol-1-yl)-phenyl]-acetic acid	Investigative	767161	C14H15NO2	229.27	CC1=CC=C(N1C2=CC=C(C=C2)CC(=O)O)C	IC50 = 124900 nM	Poor binder
T40332	Neutrophil elastase	BJ4XD5	N-[3-[(4-Fluorophenyl)methoxy]phenyl]-1-pyridin-4-ylpiperidine-4-carboxamide	Investigative	72712049	C24H24FN3O2	405.5	C1CN(CCC1C(=O)NC2=CC(=CC=C2)OCC3=CC=C(C=C3)F)C4=CC=NC=C4	Ki = 68700 nM	Poor binder
T40332	Neutrophil elastase	BJUQ13	2-(3-Fluoroanilino)-5H-[1,3]thiazino[5,4-b]indol-4-one	Investigative	44317149	C16H10FN3OS	311.3	C1=CC=C2C(=C1)C3=C(N2)C(=O)SC(=N3)NC4=CC(=CC=C4)F	Ki ~ 72000 nM	Poor binder
T40332	Neutrophil elastase	BK30LT	[4-[[2-[(E)-N-Hydroxy-C-methylcarbonimidoyl]phenyl]sulfamoyl]phenyl] 2,2-dimethylpropanoate	Investigative	91820630	C19H22N2O5S	390.5	C/C(=N\\O)/C1=CC=CC=C1NS(=O)(=O)C2=CC=C(C=C2)OC(=O)C(C)(C)C	IC50 = 51260 nM	Poor binder
T40332	Neutrophil elastase	BK3E5C	2-[[4-(4-Methylphenyl)-5-(naphthalen-2-yloxymethyl)-1,2,4-triazol-3-yl]sulfanyl]acetic acid	Investigative	90666510	C22H19N3O3S	405.5	CC1=CC=C(C=C1)N2C(=NN=C2SCC(=O)O)COC3=CC4=CC=CC=C4C=C3	IC50 ~ 100000 nM	Poor binder
T40332	Neutrophil elastase	BK7W3E	2-Amino-4H-3,1-benzoxazin-4-one	Investigative	9834041	C8H6N2O2	162.15	C1=CC=C2C(=C1)C(=O)OC(=N2)N	Ki = 63000 nM	Poor binder
T40332	Neutrophil elastase	BLI34B	2-[(2S)-2-[[(2S)-2-(3,3-Dimethylbutanoylamino)-3,3-dimethylbutanoyl]amino]-4-methylpentyl]sulfanyl-4-oxo-N-[(1S)-1-phenylpropyl]azetidine-1-carboxamide	Investigative	44282051	C31H50N4O4S	574.8	CC[C@@H](C1=CC=CC=C1)NC(=O)N2C(CC2=O)SC[C@H](CC(C)C)NC(=O)[C@H](C(C)(C)C)NC(=O)CC(C)(C)C	IC50 ~ 75000 nM	Poor binder
T40332	Neutrophil elastase	BMX70R	2-[[(E)-3-[4-(4-Carbamimidoylphenoxy)carbonylphenyl]-2-methylprop-2-enoyl]-prop-2-enylamino]acetic acid;methanesulfonic acid	Investigative	44318819	C24H27N3O8S	517.6	C/C(=C\\C1=CC=C(C=C1)C(=O)OC2=CC=C(C=C2)C(=N)N)/C(=O)N(CC=C)CC(=O)O.CS(=O)(=O)O	IC50 ~ 100000 nM	Poor binder
T40332	Neutrophil elastase	BN56LG	6-O-E-Pcoumaroyl scandoside methyl ester	Investigative	44584784	C26H30O13	550.5	COC(=O)C1=CO[C@H]([C@H]2[C@@H]1[C@@H](C=C2CO)OC(=O)/C=C/C3=CC=C(C=C3)O)O[C@H]4[C@@H]([C@H]([C@@H]([C@H](O4)CO)O)O)O	IC50 ~ 100000 nM	Poor binder
T40332	Neutrophil elastase	BNHQ54	cis-(S)-2-Amino-N-((1R,2R)-1-cyano-2-phenylcyclopropyl)-3-(thiophen-2-yl)propanamide	Investigative	24822701	C17H17N3OS	311.4	C1[C@@H]([C@]1(C#N)NC(=O)[C@H](CC2=CC=CS2)N)C3=CC=CC=C3	IC50 ~ 50000 nM	Poor binder
T40332	Neutrophil elastase	BOV2E3	((S)-2,2-Dimethyl-1-{(S)-3-methyl-1-[4-oxo-1-((R)-1-phenyl-ethylcarbamoyl)-azetidin-2-yloxymethyl]-butylcarbamoyl}-propyl)-carbamic acid tert-butyl ester	Investigative	482278	C29H46N4O6	546.7	C[C@H](C1=CC=CC=C1)NC(=O)N2C(CC2=O)OC[C@H](CC(C)C)NC(=O)[C@H](C(C)(C)C)NC(=O)OC(C)(C)C	IC50 ~ 75000 nM	Poor binder
T40332	Neutrophil elastase	BP9RC7	(3R,4S)-1-[(R)-[5-(2,2-Dimethyl-1,3-dioxolan-4-yl)-2,2-dimethyl-1,3-dioxolan-4-yl]-(1,3-dithian-2-yl)methyl]-3-methoxy-4-[(E)-2-phenylethenyl]azetidin-2-one	Investigative	44319367	C27H37NO6S2	535.7	CC1(OCC(O1)C2C(OC(O2)(C)C)[C@H](C3SCCCS3)N4[C@H]([C@H](C4=O)OC)/C=C/C5=CC=CC=C5)C	IC50 = 76000 nM	Poor binder
T40332	Neutrophil elastase	BQB9A5	2-Oxo-4-phenethylsulfanyl-N-[(1R)-1-phenylethyl]azetidine-1-carboxamide	Investigative	482284	C20H22N2O2S	354.5	C[C@H](C1=CC=CC=C1)NC(=O)N2C(CC2=O)SCCC3=CC=CC=C3	IC50 ~ 75000 nM	Poor binder
T40332	Neutrophil elastase	BQKS72	(2S,3S)-N-[(2S)-1-[[2-(Butylamino)-2-oxoethyl]amino]-4-methyl-1-oxopentan-2-yl]-3-methyl-2-[(2-phenylacetyl)amino]pentanamide	Investigative	71462857	C26H42N4O4	474.6	CCCCNC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H]([C@@H](C)CC)NC(=O)CC1=CC=CC=C1	IC50 = 51000 nM	Poor binder
T40332	Neutrophil elastase	BQR6Y0	CID 57671050	Investigative	57671050	C22H24ClN3O7	477.9	CC[C@H](C1=CC(=CO1)C(=O)O)NC(=O)N2CC(=O)NC[C@H](C2=O)CC3=C(C=CC(=C3)Cl)OC	IC50 ~ 100000 nM	Poor binder
T40332	Neutrophil elastase	BQTL23	12-Phenyl-2-[({[(E)-phenylmethylidene]amino}oxy)methyl]-12H-chromeno[3,2-e][1,2,4]triazolo[1,5-c]pyrimidin-9-ol	Investigative	9636571	C26H19N5O3	449.5	C1=CC=C(C=C1)/C=N/OCC2=NN3C=NC4=C(C3=N2)C(C5=C(O4)C=C(C=C5)O)C6=CC=CC=C6	IC50 ~ 100000 nM	Poor binder
T40332	Neutrophil elastase	BQY91R	2-Butyl-2-(3,5-dibutyl-4-hydroxy-6-oxopyran-2-yl)octanal	Investigative	54732424	C25H42O4	406.6	CCCCCCC(CCCC)(C=O)C1=C(C(=C(C(=O)O1)CCCC)O)CCCC	Ki = 151356.12 nM	Poor binder
T40332	Neutrophil elastase	BR2U9I	[((2S,5R,6S)-6-Methoxy-3,3-dimethyl-4,4,7-trioxo-4lambda*6*-thia-1-aza-bicyclo[3.2.0]heptane-2-carbonyl)-methyl-amino]-acetic acid	Investigative	44313131	C12H18N2O7S	334.35	CC1([C@@H](N2[C@H](S1(=O)=O)[C@H](C2=O)OC)C(=O)N(C)CC(=O)O)C	Ki = 53000 nM	Poor binder
T40332	Neutrophil elastase	BR8C5L	(R)-3-((S)-2-Acetylamino-3-carboxy-propionylamino)-N-((1S,2S)-1-{(S)-1-[2-((R)-1-benzylcarbamoyl-butylcarbamoyl)-pyrrolidine-1-carbonyl]-2-methyl-propylcarbamoyl}-2-methyl-butyl)-succinamic acid	Investigative	73353012	C38H57N7O11	787.9	CCC[C@H](C(=O)NCC1=CC=CC=C1)NC(=O)[C@@H]2CCCN2C(=O)[C@H](C(C)C)NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@@H](CC(=O)O)NC(=O)[C@H](CC(=O)O)NC(=O)C	IC50 = 120000 nM	Poor binder
T40332	Neutrophil elastase	BRT8S9	((S)-2,2-Dimethyl-1-{(S)-3-methyl-1-[4-oxo-1-((S)-1-phenyl-ethylcarbamoyl)-azetidin-2-yloxymethyl]-butylcarbamoyl}-propyl)-carbamic acid tert-butyl ester	Investigative	482279	C29H46N4O6	546.7	C[C@@H](C1=CC=CC=C1)NC(=O)N2C(CC2=O)OC[C@H](CC(C)C)NC(=O)[C@H](C(C)(C)C)NC(=O)OC(C)(C)C	IC50 ~ 75000 nM	Poor binder
T40332	Neutrophil elastase	BSV7X4	[(S)-1-((2S,3S)-2-Butoxy-4-oxo-azetidin-3-ylcarbamoyl)-2-phenyl-ethyl]-carbamic acid benzyl ester	Investigative	44279823	C24H29N3O5	439.5	CCCCO[C@H]1[C@@H](C(=O)N1)NC(=O)[C@H](CC2=CC=CC=C2)NC(=O)OCC3=CC=CC=C3	IC50 ~ 50000 nM	Poor binder
T40332	Neutrophil elastase	BT01HE	C19H17N5OS3	Investigative	1993219	C19H17N5OS3	427.6	C1CC2=C(C1)SC3=C2C4=NN=C(N4C(=N3)SCC5=CC=CC=C5)SCC(=O)N	IC50 ~ 100000 nM	Poor binder
T40332	Neutrophil elastase	BU83LA	4'-O-Methyldiplacone	Investigative	24854122	C26H30O6	438.5	CC(=CCC/C(=C/CC1=C(C2=C(C=C1O)O[C@@H](CC2=O)C3=CC(=C(C=C3)OC)O)O)/C)C	IC50 = 59100 nM	Poor binder
T40332	Neutrophil elastase	BUW9V4	[(S)-1-((2S,3R)-2-Benzenesulfonyl-4-oxo-azetidin-3-ylcarbamoyl)-2-phenyl-ethyl]-carbamic acid benzyl ester	Investigative	10346121	C26H25N3O6S	507.6	C1=CC=C(C=C1)C[C@@H](C(=O)N[C@H]2[C@@H](NC2=O)S(=O)(=O)C3=CC=CC=C3)NC(=O)OCC4=CC=CC=C4	IC50 ~ 50000 nM	Poor binder
T40332	Neutrophil elastase	BUZ5I7	((S)-2-Methyl-1-{(S)-2-[(S)-2-methyl-1-(1-methyl-1H-imidazole-2-carbonyl)-propylcarbamoyl]-pyrrolidine-1-carbonyl}-propyl)-carbamic acid benzyl ester	Investigative	10052095	C27H37N5O5	511.6	CC(C)[C@@H](C(=O)C1=NC=CN1C)NC(=O)[C@@H]2CCCN2C(=O)[C@H](C(C)C)NC(=O)OCC3=CC=CC=C3	Ki = 80000 nM	Poor binder
T40332	Neutrophil elastase	BV6Y2P	[(S)-1-((2S,3S)-2-Benzyloxy-4-oxo-azetidin-3-ylcarbamoyl)-2-phenyl-ethyl]-carbamic acid benzyl ester	Investigative	44279792	C27H27N3O5	473.5	C1=CC=C(C=C1)C[C@@H](C(=O)N[C@H]2[C@@H](NC2=O)OCC3=CC=CC=C3)NC(=O)OCC4=CC=CC=C4	IC50 ~ 50000 nM	Poor binder
T40332	Neutrophil elastase	BVP1Q6	(3S)-1-Diazo-3-[(aminoacetyl)amino]-4-(4-iodophenyl)-2-butanone	Investigative	102323332	C12H13IN4O2	372.16	C1=CC(=CC=C1C[C@@H](C(=O)C=[N+]=[N-])NC(=O)CN)I	IC50 ~ 50000 nM	Poor binder
T40332	Neutrophil elastase	BVW60I	2-Chloro-5-[[(4Z)-4-[(4-methylsulfanylphenyl)methylidene]-5-oxoimidazol-1-yl]sulfamoyl]benzoic acid	Investigative	44415219	C18H14ClN3O5S2	451.9	CSC1=CC=C(C=C1)/C=C\\2/C(=O)N(C=N2)NS(=O)(=O)C3=CC(=C(C=C3)Cl)C(=O)O	IC50 = 75800 nM	Poor binder
T40332	Neutrophil elastase	BW47VB	2-[[5-(4-Chlorophenyl)-[1,3]thiazolo[2,3-c][1,2,4]triazol-3-yl]sulfanyl]-N-(pyridin-3-ylmethyl)acetamide	Investigative	3223864	C18H14ClN5OS2	415.9	C1=CC(=CN=C1)CNC(=O)CSC2=NN=C3N2C(=CS3)C4=CC=C(C=C4)Cl	IC50 ~ 100000 nM	Poor binder
T40332	Neutrophil elastase	BW86IX	[(S)-1-((S)-2-Oxo-azetidin-3-ylcarbamoyl)-2-phenyl-ethyl]-carbamic acid benzyl ester	Investigative	44279951	C20H21N3O4	367.4	C1[C@@H](C(=O)N1)NC(=O)[C@H](CC2=CC=CC=C2)NC(=O)OCC3=CC=CC=C3	IC50 ~ 50000 nM	Poor binder
T40332	Neutrophil elastase	BW8IC4	Chembl4168536	Investigative	145953439	C25H30O6	426.5	CC1(CCC2=C(C3=C(C=C2O1)O[C@@H](CC3=O)C4=CC=C(C=C4)O)O)CCCC(C)(C)O	IC50 ~ 100000 nM	Poor binder
T40332	Neutrophil elastase	BWA3N8	Elasnin	Investigative	54685126	C24H40O4	392.6	CCCCCC(=O)C(CCCC)C1=C(C(=C(C(=O)O1)CCCC)O)CCCC	Ki = 93325.43 nM	Poor binder
T40332	Neutrophil elastase	BX0G5F	2-(3,5-Difluoropyridin-2-yl)-4,5,6,7-tetrahydro-1,2-benzisothiazol-3(2H)-one 1,1-dioxide	Investigative	44561893	C12H10F2N2O3S	300.28	C1CCC2=C(C1)C(=O)N(S2(=O)=O)C3=C(C=C(C=N3)F)F	IC50 ~ 100000 nM	Poor binder
T40332	Neutrophil elastase	BX1D3Z	4-Hydroxy-6-undecyl-1H-pyridin-2-one	Investigative	54728809	C16H27NO2	265.39	CCCCCCCCCCCC1=CC(=CC(=O)N1)O	IC50 = 153000 nM	Poor binder
T40332	Neutrophil elastase	BX1D6A	(2S)-1-[(2S)-3-Methyl-2-[[4-(morpholine-4-carbonyl)benzoyl]amino]butanoyl]-N-(3,3,4,4,4-pentafluoro-2-oxobutyl)pyrrolidine-2-carboxamide	Investigative	10371190	C26H31F5N4O6	590.5	CC(C)[C@@H](C(=O)N1CCC[C@H]1C(=O)NCC(=O)C(C(F)(F)F)(F)F)NC(=O)C2=CC=C(C=C2)C(=O)N3CCOCC3	Ki = 150000 nM	Poor binder
T40332	Neutrophil elastase	BX3I0E	Ethyl 1-(2-methylbenzoyl)indazole-3-carboxylate	Investigative	56663149	C18H16N2O3	308.3	CCOC(=O)C1=NN(C2=CC=CC=C21)C(=O)C3=CC=CC=C3C	IC50 = 52000 nM	Poor binder
T40332	Neutrophil elastase	BXE52A	2-Benzylsulfanyl-4-oxo-N-[(1R)-1-phenylethyl]azetidine-1-carboxamide	Investigative	482283	C19H20N2O2S	340.4	C[C@H](C1=CC=CC=C1)NC(=O)N2C(CC2=O)SCC3=CC=CC=C3	IC50 ~ 75000 nM	Poor binder
T40332	Neutrophil elastase	BXQ65N	N-Benzyl-2-(4-benzyl-5-cyclopropyl-4H-[1,2,4]triazol-3-ylsulfanyl)-acetamide	Investigative	1457429	C21H22N4OS	378.5	C1CC1C2=NN=C(N2CC3=CC=CC=C3)SCC(=O)NCC4=CC=CC=C4	IC50 ~ 100000 nM	Poor binder
T40332	Neutrophil elastase	BY81PJ	(S)-N1-(1-(Benzo[d]oxazol-2-yl)-1-oxopropan-2-yl)-2-((S)-2-(3,3-dimethylbutanamido)-3,3-dimethylbutanamido)-N4,N4-dimethylsuccinamide	Investigative	10506703	C28H41N5O6	543.7	CC(C(=O)C1=NC2=CC=CC=C2O1)NC(=O)[C@H](CC(=O)N(C)C)NC(=O)[C@H](C(C)(C)C)NC(=O)CC(C)(C)C	IC50 = 183000 nM	Poor binder
T40332	Neutrophil elastase	BYU1X7	(2S)-3',5'-Dimethoxy-4',5,7-trihydroxy-6-[(2E)-3,7-dimethyl-2,6-octadienyl]-2,3-dihydroflavone	Investigative	24854123	C27H32O7	468.5	CC(=CCC/C(=C/CC1=C(C2=C(C=C1O)O[C@@H](CC2=O)C3=CC(=C(C(=C3)OC)O)OC)O)/C)C	IC50 = 71300 nM	Poor binder
T40332	Neutrophil elastase	BYW67N	6-O-Z-Pcoumaroyl scandoside methyl ester	Investigative	44584783	C26H30O13	550.5	COC(=O)C1=CO[C@H]([C@H]2[C@@H]1[C@@H](C=C2CO)OC(=O)/C=C\\C3=CC=C(C=C3)O)O[C@H]4[C@@H]([C@H]([C@@H]([C@H](O4)CO)O)O)O	IC50 ~ 100000 nM	Poor binder
T40332	Neutrophil elastase	BYZO65	[4-Oxo-6-[(5-phenyl-1,3,4-thiadiazol-2-yl)sulfanylmethyl]pyran-3-yl] 2-methoxybenzoate	Investigative	72793745	C22H16N2O5S2	452.5	COC1=CC=CC=C1C(=O)OC2=COC(=CC2=O)CSC3=NN=C(S3)C4=CC=CC=C4	IC50 ~ 50000 nM	Poor binder
T40332	Neutrophil elastase	BZ20PF	N-((1R)-1-Phenylethyl)[2-oxo-4-(4-pyridylmethylthio)azetidinyl]carboxamide	Investigative	482285	C18H19N3O2S	341.4	C[C@H](C1=CC=CC=C1)NC(=O)N2C(CC2=O)SCC3=CC=NC=C3	IC50 ~ 75000 nM	Poor binder
T40332	Neutrophil elastase	BZ24RN	(1R,21S,24S)-21-Tert-butyl-N-[(1R,2S)-1-(cyclopropylsulfonylcarbamoyl)-2-ethenylcyclopropyl]-16,16-dimethyl-3,19,22-trioxo-2,18-dioxa-4,20,23-triazatetracyclo[21.2.1.14,7.06,11]heptacosa-6(11),7,9-triene-24-carboxamide	Investigative	46228924	C38H53N5O9S	755.9	CC1(CCCCC2=C3CN(CC3=CC=C2)C(=O)O[C@@H]4C[C@H](N(C4)C(=O)[C@@H](NC(=O)OC1)C(C)(C)C)C(=O)N[C@@]5(C[C@H]5C=C)C(=O)NS(=O)(=O)C6CC6)C	IC50 ~ 100000 nM	Poor binder
T40332	Neutrophil elastase	BZ7A2V	Tomentin B	Investigative	71659628	C26H32O7	456.5	CC1(CCC2=C(C3=C(C=C2O1)O[C@@H](CC3=O)C4=CC(=C(C=C4)OC)O)O)CCCC(C)(C)O	IC50 ~ 100000 nM	Poor binder
T40332	Neutrophil elastase	BZH72A	1-(4-Chlorophenyl)-3-[4-[(5-ethyl-1,3,4-thiadiazol-2-yl)sulfamoyl]phenyl]urea	Investigative	1011274	C17H16ClN5O3S2	437.9	CCC1=NN=C(S1)NS(=O)(=O)C2=CC=C(C=C2)NC(=O)NC3=CC=C(C=C3)Cl	IC50 = 78300 nM	Poor binder
T40332	Neutrophil elastase	BZI1U2	3,5-Dibutyl-4-hydroxy-6-(1-oxo-1-phenylhexan-2-yl)pyran-2-one	Investigative	54707146	C25H34O4	398.5	CCCCC1=C(C(=C(OC1=O)C(CCCC)C(=O)C2=CC=CC=C2)CCCC)O	Ki = 95499.26 nM	Poor binder
T40332	Neutrophil elastase	BZI2E0	(4R)-4-[[(2S)-2-Acetamido-3-carboxypropanoyl]amino]-5-[[(2S,3S)-3-methyl-1-[[(2S)-3-methyl-1-[(2S,4R)-2-[[methyl-[[(1S)-1-phenylethyl]carbamoyl]amino]carbamoyl]-4-phenylmethoxypyrrolidin-1-yl]-1-oxobutan-2-yl]amino]-1-oxopentan-2-yl]amino]-5-oxopentanoic acid	Investigative	644152	C44H62N8O12	895	CC[C@H](C)[C@@H](C(=O)N[C@@H](C(C)C)C(=O)N1C[C@@H](C[C@H]1C(=O)NN(C)C(=O)N[C@@H](C)C2=CC=CC=C2)OCC3=CC=CC=C3)NC(=O)[C@@H](CCC(=O)O)NC(=O)[C@H](CC(=O)O)NC(=O)C	IC50 = 168000 nM	Poor binder
T40332	Neutrophil elastase	BZRS93	2-(4,5-Dibenzyl-4H-[1,2,4]triazol-3-ylsulfanyl)-N-furan-2-ylmethyl-acetamide	Investigative	1170184	C23H22N4O2S	418.5	C1=CC=C(C=C1)CC2=NN=C(N2CC3=CC=CC=C3)SCC(=O)NCC4=CC=CO4	IC50 ~ 100000 nM	Poor binder
T40332	Neutrophil elastase	D0I0TB	Emodin	Investigative	3220	C15H10O5	270.24	CC1=CC2=C(C(=C1)O)C(=O)C3=C(C2=O)C=C(C=C3O)O	IC50 = 52000 nM	Poor binder
T40332	Neutrophil elastase	D0S5RY	S 3025	Investigative	4784	C7H7FO2S	174.19	C1=CC=C(C=C1)CS(=O)(=O)F	IC50 = 52161.7 nM	Poor binder