TTD_Target_ID	Target_Name	TTD_Drug_ID	Drug_Name	Drug_Highest_Status	Drug_PubchemID	Molecular_Formula	Molecular_Weight	Canonical_SMILES	Activity	Binder_Type
T43721	Corticosteroid 11-beta-dehydrogenase 2	B10WDX	N-[(1S)-5-(2-Amino-2-oxoethyl)-2-adamantyl]-2-methyl-2-(5-morpholin-4-ylpyridin-2-yl)oxypropanamide	Investigative	44418395	C25H36N4O4	456.6	CC(C)(C(=O)NC1[C@H]2CC3CC1CC(C2)(C3)CC(=O)N)OC4=NC=C(C=C4)N5CCOCC5	IC50 ~ 100000 nM	Poor binder
T43721	Corticosteroid 11-beta-dehydrogenase 2	B19WYD	N-(2-Adamantyl)-2-[4-(3-cyanopyridin-2-yl)piperazin-1-yl]acetamide	Investigative	10452320	C22H29N5O	379.5	C1CN(CCN1CC(=O)NC2C3CC4CC(C3)CC2C4)C5=C(C=CC=N5)C#N	IC50 ~ 100000 nM	Poor binder
T43721	Corticosteroid 11-beta-dehydrogenase 2	B1G5WK	Chembl373601	Investigative	44418389	C19H24ClNO4	365.8	CC(C)(C(=O)NC1C2CC3CC1CC(C2)(O3)O)OC4=CC=C(C=C4)Cl	IC50 = 70000 nM	Poor binder
T43721	Corticosteroid 11-beta-dehydrogenase 2	B1YGH3	4-[2-(3,3-Difluoro-piperidin-1-yl)-butyrylamino]-adamantane-1-carboxylic acid	Investigative	44420249	C20H30F2N2O3	384.5	CCC(C(=O)NC1C2CC3CC1CC(C3)(C2)C(=O)O)N4CCCC(C4)(F)F	IC50 = 100000 nM	Poor binder
T43721	Corticosteroid 11-beta-dehydrogenase 2	B23EQW	N-(5-Methanesulfonyl-adamantan-2-yl)-2-methyl-2-(2-trifluoromethyl-phenoxy)-propionamide	Investigative	44438676	C22H28F3NO4S	459.5	CC(C)(C(=O)NC1C2CC3CC1CC(C3)(C2)S(=O)(=O)C)OC4=CC=CC=C4C(F)(F)F	IC50 ~ 100000 nM	Poor binder
T43721	Corticosteroid 11-beta-dehydrogenase 2	B24QRF	(2S)-2-[(3R)-3-Fluoropyrrolidin-1-yl]-N-(5-hydroxy-2-adamantyl)propanamide	Investigative	44418852	C17H27FN2O2	310.4	C[C@@H](C(=O)NC1C2CC3CC1CC(C3)(C2)O)N4CC[C@H](C4)F	IC50 ~ 100000 nM	Poor binder
T43721	Corticosteroid 11-beta-dehydrogenase 2	B2WT3Q	4-{2-Cyclopropyl-2-[4-(5-trifluoromethyl-pyridin-2-yl)-piperazin-1-yl]-acetylamino}-adamantane-1-carboxylic acid amide	Investigative	11649095	C26H34F3N5O2	505.6	C1CC1C(C(=O)NC2C3CC4CC2CC(C4)(C3)C(=O)N)N5CCN(CC5)C6=NC=C(C=C6)C(F)(F)F	IC50 ~ 100000 nM	Poor binder
T43721	Corticosteroid 11-beta-dehydrogenase 2	B2X7VP	N-((1R,2S,5R,7S)-5-Carbamoylmethyl-adamantan-2-yl)-2-methyl-2-[5-(4-methyl-piperazin-1-yl)-pyridin-2-yloxy]-propionamide	Investigative	44418396	C26H39N5O3	469.6	CC(C)(C(=O)NC1[C@H]2CC3CC1CC(C2)(C3)CC(=O)N)OC4=NC=C(C=C4)N5CCN(CC5)C	IC50 ~ 100000 nM	Poor binder
T43721	Corticosteroid 11-beta-dehydrogenase 2	B2ZMK0	2-[[4-[[2-(4-Chlorophenoxy)-2-methylpropanoyl]amino]-1-adamantyl]methoxy]acetic acid	Investigative	44438569	C23H30ClNO5	435.9	CC(C)(C(=O)NC1C2CC3CC1CC(C3)(C2)COCC(=O)O)OC4=CC=C(C=C4)Cl	IC50 ~ 100000 nM	Poor binder
T43721	Corticosteroid 11-beta-dehydrogenase 2	B38YCJ	2-(2-Chloro-4-fluoro-phenoxy)-2-methyl-N-(5-sulfamoyl-adamantan-2-yl)-propionamide	Investigative	11510573	C20H26ClFN2O4S	444.9	CC(C)(C(=O)NC1C2CC3CC1CC(C3)(C2)S(=O)(=O)N)OC4=C(C=C(C=C4)F)Cl	IC50 ~ 100000 nM	Poor binder
T43721	Corticosteroid 11-beta-dehydrogenase 2	B3E9BU	4-({1-[4-(5-Trifluoromethyl-pyridin-2-yl)-piperazin-1-yl]-cyclopentanecarbonyl}-amino)-adamantane-1-carboxylic acid amide	Investigative	44420244	C27H36F3N5O2	519.6	C1CCC(C1)(C(=O)NC2C3CC4CC2CC(C4)(C3)C(=O)N)N5CCN(CC5)C6=NC=C(C=C6)C(F)(F)F	IC50 = 50000 nM	Poor binder
T43721	Corticosteroid 11-beta-dehydrogenase 2	B3NP5I	N-(5-Hydroxy-adamantan-2-yl)-2-(3-trifluoromethyl-pyrrolidin-1-yl)-acetamide	Investigative	44418821	C17H25F3N2O2	346.4	C1CN(C[C@H]1C(F)(F)F)CC(=O)NC2C3CC4CC2CC(C4)(C3)O	IC50 ~ 100000 nM	Poor binder
T43721	Corticosteroid 11-beta-dehydrogenase 2	B4OQA0	N-(1-Hydroxy-adamantan-2-yl)-2-[4-(5-trifluoromethyl-pyridin-2-yl)-piperazin-1-yl]-acetamide	Investigative	44418817	C22H29F3N4O2	438.5	C1CN(CCN1CC(=O)NC2C3CC4CC(C3)CC2(C4)O)C5=NC=C(C=C5)C(F)(F)F	IC50 ~ 100000 nM	Poor binder
T43721	Corticosteroid 11-beta-dehydrogenase 2	B4TB6R	N-[(E)-5-Fluoro-2-adamantyl]-2-{4-[5-(trifluoromethyl)pyridin-2-yl]piperazin-1-yl}acetamide	Investigative	11655097	C22H28F4N4O	440.5	C1CN(CCN1CC(=O)NC2C3CC4CC2CC(C4)(C3)F)C5=NC=C(C=C5)C(F)(F)F	IC50 ~ 100000 nM	Poor binder
T43721	Corticosteroid 11-beta-dehydrogenase 2	B6KXQ7	1-(1-Adamantyl)-3-[(1S,4S,5R,9S,10R,13S)-5,9-dimethyl-14-methylidene-5-tetracyclo[11.2.1.01,10.04,9]hexadecanyl]urea	Investigative	73355069	C30H46N2O	450.7	C[C@@]12CCC[C@@]([C@H]1CC[C@]34[C@H]2CC[C@@H](C3)C(=C)C4)(C)NC(=O)NC56CC7CC(C5)CC(C7)C6	IC50 ~ 100000 nM	Poor binder
T43721	Corticosteroid 11-beta-dehydrogenase 2	B6PF0M	Spiro-carboxamide scaffold, 5	Investigative	44143291	C23H24ClNO	365.9	C1CC2=CC=CC=C2C3(C1)CCN(C3)C(=O)C4(CC4)C5=CC=C(C=C5)Cl	IC50 ~ 100000 nM	Poor binder
T43721	Corticosteroid 11-beta-dehydrogenase 2	B76ASC	(2R)-3,3,3-Trifluoro-2-[5-[(2R)-4-[4-fluoro-2-(trifluoromethyl)phenyl]-2-methylpiperazin-1-yl]sulfonylthiophen-2-yl]-2-hydroxypropanamide	Investigative	49846481	C19H18F7N3O4S2	549.5	C[C@@H]1CN(CCN1S(=O)(=O)C2=CC=C(S2)[C@@](C(=O)N)(C(F)(F)F)O)C3=C(C=C(C=C3)F)C(F)(F)F	IC50 ~ 100000 nM	Poor binder
T43721	Corticosteroid 11-beta-dehydrogenase 2	B7VEC0	2-[3-(2-Fluoro-phenoxy)-azetidin-1-yl]-N-(5-hydroxy-adamantan-2-yl)-propionamide	Investigative	44418856	C22H29FN2O3	388.5	CC(C(=O)NC1C2CC3CC1CC(C3)(C2)O)N4CC(C4)OC5=CC=CC=C5F	IC50 = 56000 nM	Poor binder
T43721	Corticosteroid 11-beta-dehydrogenase 2	B86DPI	2-Phenyl-N-(5-sulfamoyl-adamantan-2-yl)-isobutyramide	Investigative	44438681	C20H28N2O3S	376.5	CC(C)(C1=CC=CC=C1)C(=O)NC2C3CC4CC2CC(C4)(C3)S(=O)(=O)N	IC50 ~ 100000 nM	Poor binder
T43721	Corticosteroid 11-beta-dehydrogenase 2	B8W9XT	4-{2-[4-(5-Trifluoromethyl-pyridin-2-yl)-piperazin-1-yl]-butyrylamino}-adamantane-1-carboxylic acid amide	Investigative	11540493	C25H34F3N5O2	493.6	CCC(C(=O)NC1C2CC3CC1CC(C3)(C2)C(=O)N)N4CCN(CC4)C5=NC=C(C=C5)C(F)(F)F	IC50 ~ 100000 nM	Poor binder
T43721	Corticosteroid 11-beta-dehydrogenase 2	B9OX1H	(3r,9r)-9-(2-(4-Chlorophenoxy)-2-methylpropanamido)bicyclo[3.3.1]nonane-3-carboxamide	Investigative	44418382	C20H27ClN2O3	378.9	CC(C)(C(=O)NC1C2CCCC1CC(C2)C(=O)N)OC3=CC=C(C=C3)Cl	IC50 ~ 100000 nM	Poor binder
T43721	Corticosteroid 11-beta-dehydrogenase 2	B9SQP2	CID 57418438	Investigative	57418438	C19H19F7N2O3S2	520.5	C[C@@H]1CN(CCN1S(=O)(=O)C2=CC=C(S2)[C@](C)(C(F)(F)F)O)C3=C(C=C(C=C3)F)C(F)(F)F	IC50 ~ 100000 nM	Poor binder
T43721	Corticosteroid 11-beta-dehydrogenase 2	BA4G7R	N-[(1R,2S,5S,7S)-5-(5-Amino-4H-[1,2,4]triazol-3-yl)-adamantan-2-yl]-2-(4-chloro-phenoxy)-2-methyl-propionamide	Investigative	44418451	C22H28ClN5O2	429.9	CC(C)(C(=O)NC1[C@H]2CC3CC1CC(C2)(C3)C4=NC(=NN4)N)OC5=CC=C(C=C5)Cl	IC50 = 55000 nM	Poor binder
T43721	Corticosteroid 11-beta-dehydrogenase 2	BAC1S5	(7r,9r)-9-(2-(4-Chlorophenoxy)-2-methylpropanamido)-3-oxa-bicyclo[3.3.1]nonane-7-carboxamide	Investigative	44418383	C19H25ClN2O4	380.9	CC(C)(C(=O)NC1C2CC(CC1COC2)C(=O)N)OC3=CC=C(C=C3)Cl	IC50 ~ 100000 nM	Poor binder
T43721	Corticosteroid 11-beta-dehydrogenase 2	BC5S0O	4-({1-[4-(5-Trifluoromethyl-pyridin-2-yl)-piperazin-1-yl]-cyclopropanecarbonyl}-amino)-adamantane-1-carboxylic acid amide	Investigative	11705872	C25H32F3N5O2	491.5	C1CC1(C(=O)NC2C3CC4CC2CC(C4)(C3)C(=O)N)N5CCN(CC5)C6=NC=C(C=C6)C(F)(F)F	IC50 ~ 100000 nM	Poor binder
T43721	Corticosteroid 11-beta-dehydrogenase 2	BD52OX	2-(4-Chloro-phenoxy)-N-(5-methanesulfonyl-adamantan-2-yl)-2-methyl-propionamide	Investigative	44438675	C21H28ClNO4S	426	CC(C)(C(=O)NC1C2CC3CC1CC(C3)(C2)S(=O)(=O)C)OC4=CC=C(C=C4)Cl	IC50 = 65000 nM	Poor binder
T43721	Corticosteroid 11-beta-dehydrogenase 2	BDCZ97	(3r,9r)-9-(2-Methyl-2-(4-(5-(trifluoromethyl)pyridin-2-yl)piperazin-1-yl)propanamido)bicyclo[3.3.1]nonane-3-carboxamide	Investigative	44418445	C24H34F3N5O2	481.6	CC(C)(C(=O)NC1C2CCCC1CC(C2)C(=O)N)N3CCN(CC3)C4=NC=C(C=C4)C(F)(F)F	IC50 ~ 100000 nM	Poor binder
T43721	Corticosteroid 11-beta-dehydrogenase 2	BE1N8A	N-((1R,2S,5R,7S)-5-Carbamoylmethyl-adamantan-2-yl)-2-(5-cyano-pyridin-2-yloxy)-2-methyl-propionamide	Investigative	44418391	C22H28N4O3	396.5	CC(C)(C(=O)NC1[C@H]2CC3CC1CC(C2)(C3)CC(=O)N)OC4=NC=C(C=C4)C#N	IC50 ~ 100000 nM	Poor binder
T43721	Corticosteroid 11-beta-dehydrogenase 2	BEPQ21	N-((1R,2S,5R,7S)-5-Carbamoylmethyl-adamantan-2-yl)-2-(6-methylamino-pyridin-3-yl)-isobutyramide	Investigative	44418409	C22H32N4O2	384.5	CC(C)(C1=CN=C(C=C1)NC)C(=O)NC2[C@H]3CC4CC2CC(C3)(C4)CC(=O)N	IC50 ~ 100000 nM	Poor binder
T43721	Corticosteroid 11-beta-dehydrogenase 2	BEZ12T	{(1R,4S,5R,7S)-4-[2-(4-Chloro-phenoxy)-2-methyl-propionylamino]-adamantan-1-yl}-acetic acid	Investigative	44418378	C22H28ClNO4	405.9	CC(C)(C(=O)NC1[C@H]2CC3CC1CC(C2)(C3)CC(=O)O)OC4=CC=C(C=C4)Cl	IC50 = 52000 nM	Poor binder
T43721	Corticosteroid 11-beta-dehydrogenase 2	BF3SW8	4-{2-[4-(5-Trifluoromethyl-pyridin-2-yl)-piperazin-1-yl]-butyrylamino}-adamantane-1-carboxylic acid	Investigative	44420285	C25H33F3N4O3	494.5	CCC(C(=O)NC1C2CC3CC1CC(C3)(C2)C(=O)O)N4CCN(CC4)C5=NC=C(C=C5)C(F)(F)F	IC50 = 65000 nM	Poor binder
T43721	Corticosteroid 11-beta-dehydrogenase 2	BGTF37	1-Cyclohexyl-3-[(1R,4S,5R,9R,10S,11S,13R,15R)-11,15-dihydroxy-5,9-dimethyl-14-methylidene-5-tetracyclo[11.2.1.01,10.04,9]hexadecanyl]urea	Investigative	73352112	C26H42N2O3	430.6	C[C@@]12CCC[C@@]([C@H]1CC[C@]34[C@H]2[C@H](C[C@@H](C3)C(=C)[C@H]4O)O)(C)NC(=O)NC5CCCCC5	IC50 ~ 100000 nM	Poor binder
T43721	Corticosteroid 11-beta-dehydrogenase 2	BH06RZ	N-[(1R,3S)-5-Hydroxy-2-adamantyl]-2-(6,7,9,10-tetrahydro-8H-[1,3]dioxolo[4,5-g][3]benzazepin-8-yl)propanamide	Investigative	44418857	C24H32N2O4	412.5	CC(C(=O)NC1C2CC3CC1CC(C3)(C2)O)N4CCC5=C(CC4)C6=C(C=C5)OCO6	IC50 = 62000 nM	Poor binder
T43721	Corticosteroid 11-beta-dehydrogenase 2	BH8IM9	1-{[(3R)-3-Methyl-4-({4-[(1S)-2,2,2-trifluoro-1-hydroxy-1-methylethyl]phenyl}sulfonyl)piperazin-1-yl]methyl}cyclopropanecarboxamide	Investigative	24856362	C19H26F3N3O4S	449.5	C[C@@H]1CN(CCN1S(=O)(=O)C2=CC=C(C=C2)[C@@](C)(C(F)(F)F)O)CC3(CC3)C(=O)N	IC50 ~ 100000 nM	Poor binder
T43721	Corticosteroid 11-beta-dehydrogenase 2	BIP8R1	2-(4-Chloro-phenoxy)-N-(5-dimethylsulfamoyl-adamantan-2-yl)-2-methyl-propionamide	Investigative	11712182	C22H31ClN2O4S	455	CC(C)(C(=O)NC1C2CC3CC1CC(C3)(C2)S(=O)(=O)N(C)C)OC4=CC=C(C=C4)Cl	IC50 = 60000 nM	Poor binder
T43721	Corticosteroid 11-beta-dehydrogenase 2	BK0Z7D	Spiro-carboxamide scaffold, 13	Investigative	44143299	C19H25NO	283.4	C1CCC2(CC1)CCN(C2)C(=O)C3(CC3)C4=CC=CC=C4	IC50 ~ 100000 nM	Poor binder
T43721	Corticosteroid 11-beta-dehydrogenase 2	BK13TX	N-((1R,2S,5R,7S)-5-Carbamoylmethyl-adamantan-2-yl)-2-methyl-2-(5-pyrazol-1-yl-pyridin-2-yloxy)-propionamide	Investigative	44418400	C24H31N5O3	437.5	CC(C)(C(=O)NC1[C@H]2CC3CC1CC(C2)(C3)CC(=O)N)OC4=NC=C(C=C4)N5C=CC=N5	IC50 ~ 100000 nM	Poor binder
T43721	Corticosteroid 11-beta-dehydrogenase 2	BM5W6X	N-((1R,2S,5R,7S)-5-Carbamoylmethyl-adamantan-2-yl)-2-(5-cyano-pyridin-2-yl)-isobutyramide	Investigative	44418401	C22H28N4O2	380.5	CC(C)(C1=NC=C(C=C1)C#N)C(=O)NC2[C@H]3CC4CC2CC(C3)(C4)CC(=O)N	IC50 ~ 100000 nM	Poor binder
T43721	Corticosteroid 11-beta-dehydrogenase 2	BME2S8	4-(2-(4-Chlorophenoxy)-2-methylpropanamido)bicyclo[2.2.2]octane-1-carboxamide	Investigative	16049788	C19H25ClN2O3	364.9	CC(C)(C(=O)NC12CCC(CC1)(CC2)C(=O)N)OC3=CC=C(C=C3)Cl	IC50 = 100000 nM	Poor binder
T43721	Corticosteroid 11-beta-dehydrogenase 2	BMW24A	3-{(1R,4S,5R,7S)-4-[2-(4-Chloro-phenoxy)-2-methyl-propionylamino]-adamantan-1-yl}-propionic acid	Investigative	44418385	C23H30ClNO4	419.9	CC(C)(C(=O)NC1[C@H]2CC3CC1CC(C2)(C3)CCC(=O)O)OC4=CC=C(C=C4)Cl	IC50 = 100000 nM	Poor binder
T43721	Corticosteroid 11-beta-dehydrogenase 2	BNP89T	(3s,9s)-9-(2-(5-Cyanopyridin-2-yloxy)-2-methylpropanamido)bicyclo[3.3.1]nonane-3-carboxamide	Investigative	44418375	C20H26N4O3	370.4	CC(C)(C(=O)NC1C2CCCC1CC(C2)C(=O)N)OC3=NC=C(C=C3)C#N	IC50 ~ 100000 nM	Poor binder
T43721	Corticosteroid 11-beta-dehydrogenase 2	BO6BU7	N-[(1R,2S,5S,7S)-5-(5-Amino-4-cyano-oxazol-2-yl)-adamantan-2-yl]-2-(4-chloro-phenoxy)-2-methyl-propionamide	Investigative	44418447	C24H27ClN4O3	454.9	CC(C)(C(=O)NC1[C@H]2CC3CC1CC(C2)(C3)C4=NC(=C(O4)N)C#N)OC5=CC=C(C=C5)Cl	IC50 ~ 100000 nM	Poor binder
T43721	Corticosteroid 11-beta-dehydrogenase 2	BOK10H	Caloncobic acid A	Investigative	57408764	C30H46O4	470.7	C[C@H](CC[C@@H](C(=C)C)O)[C@H]1CC[C@@]2([C@@]1(CC[C@]34[C@H]2CC[C@@H]5[C@]3(C4)CCC(=O)C5(C)C)C)C(=O)O	IC50 ~ 100000 nM	Poor binder
T43721	Corticosteroid 11-beta-dehydrogenase 2	BOK4L3	(3r,9r)-9-(2-Methyl-2-(4-(5-(trifluoromethyl)pyridin-2-yl)piperazin-1-yl)propanamido)bicyclo[3.3.1]nonane-3-carboxylic acid	Investigative	44418450	C24H33F3N4O3	482.5	CC(C)(C(=O)NC1C2CCCC1CC(C2)C(=O)O)N3CCN(CC3)C4=NC=C(C=C4)C(F)(F)F	IC50 ~ 100000 nM	Poor binder
T43721	Corticosteroid 11-beta-dehydrogenase 2	BPA7U2	Spiro-carboxamide scaffold, 6	Investigative	44143292	C19H24ClNO	317.9	C1CCC2(CC1)CCN(C2)C(=O)C3(CC3)C4=CC=C(C=C4)Cl	IC50 ~ 100000 nM	Poor binder
T43721	Corticosteroid 11-beta-dehydrogenase 2	BPSO89	N-[(E)-5-Hydroxy-2-adamantyl]-2-{4-[5-(trifluoromethyl)pyridin-2-yl]piperazin-1-yl}acetamide	Investigative	11495851	C22H29F3N4O2	438.5	C1CN(CCN1CC(=O)NC2C3CC4CC2CC(C4)(C3)O)C5=NC=C(C=C5)C(F)(F)F	IC50 ~ 100000 nM	Poor binder
T43721	Corticosteroid 11-beta-dehydrogenase 2	BR2T9E	N-((1R,2S,5R,7S)-5-Carbamoylmethyl-adamantan-2-yl)-2-(6-morpholin-4-yl-pyridin-3-yl)-isobutyramide	Investigative	44418408	C25H36N4O3	440.6	CC(C)(C1=CN=C(C=C1)N2CCOCC2)C(=O)NC3[C@H]4CC5CC3CC(C4)(C5)CC(=O)N	IC50 ~ 100000 nM	Poor binder
T43721	Corticosteroid 11-beta-dehydrogenase 2	BR4OZ0	4-[[2-(4-Chlorophenoxy)-2-methylpropanoyl]amino]-N-[[4-(methylsulfonylcarbamoyl)phenyl]methyl]adamantane-1-carboxamide	Investigative	11505338	C30H36ClN3O6S	602.1	CC(C)(C(=O)NC1C2CC3CC1CC(C3)(C2)C(=O)NCC4=CC=C(C=C4)C(=O)NS(=O)(=O)C)OC5=CC=C(C=C5)Cl	IC50 = 50000 nM	Poor binder
T43721	Corticosteroid 11-beta-dehydrogenase 2	BR6N1G	1-[(1R,4S,5R,9R,10S,11S,13R,15R)-11,15-Dihydroxy-5,9-dimethyl-14-methylidene-5-tetracyclo[11.2.1.01,10.04,9]hexadecanyl]-3-(4-fluorophenyl)urea	Investigative	73353568	C26H35FN2O3	442.6	C[C@@]12CCC[C@@]([C@H]1CC[C@]34[C@H]2[C@H](C[C@@H](C3)C(=C)[C@H]4O)O)(C)NC(=O)NC5=CC=C(C=C5)F	IC50 ~ 100000 nM	Poor binder
T43721	Corticosteroid 11-beta-dehydrogenase 2	BR82KT	N-[(E)-5-Hydroxy-2-adamantyl]-2-{4-[5-(trifluoromethyl)pyridin-2-yl]piperazin-1-yl}propionamide	Investigative	11676805	C23H31F3N4O2	452.5	CC(C(=O)NC1C2CC3CC1CC(C3)(C2)O)N4CCN(CC4)C5=NC=C(C=C5)C(F)(F)F	IC50 ~ 100000 nM	Poor binder
T43721	Corticosteroid 11-beta-dehydrogenase 2	BRK12S	2-(4-Chloro-phenoxy)-N-[(1R,2S,5S,7S)-5-(N-hydroxycarbamimidoyl)-adamantan-2-yl]-2-methyl-propionamide	Investigative	44418459	C21H28ClN3O3	405.9	CC(C)(C(=O)NC1[C@H]2CC3CC1CC(C2)(C3)/C(=N/O)/N)OC4=CC=C(C=C4)Cl	IC50 = 100000 nM	Poor binder
T43721	Corticosteroid 11-beta-dehydrogenase 2	BRN40X	9-(4-{[(5-Cyanopyridin-2-yl)oxy]methyl}-3,3-dimethyl-2-oxopyrrolidin-1-yl)bicyclo[3.3.1]nonane-3-carboxamide	Investigative	24889906	C23H30N4O3	410.5	CC1(C(CN(C1=O)C2C3CCCC2CC(C3)C(=O)N)COC4=NC=C(C=C4)C#N)C	IC50 ~ 100000 nM	Poor binder
T43721	Corticosteroid 11-beta-dehydrogenase 2	BRP9A4	1-[(1S,4S,5R,9S,10R,13S)-5,9-Dimethyl-14-methylidene-5-tetracyclo[11.2.1.01,10.04,9]hexadecanyl]-3-(4-fluorophenyl)urea	Investigative	73352110	C26H35FN2O	410.6	C[C@@]12CCC[C@@]([C@H]1CC[C@]34[C@H]2CC[C@@H](C3)C(=C)C4)(C)NC(=O)NC5=CC=C(C=C5)F	IC50 ~ 100000 nM	Poor binder
T43721	Corticosteroid 11-beta-dehydrogenase 2	BRQ84Y	2-(4-Chlorophenoxy)-N-(5-cyanocyclooctyl)-2-methylpropanamide	Investigative	44418457	C19H25ClN2O2	348.9	CC(C)(C(=O)NC1CCCC(CCC1)C#N)OC2=CC=C(C=C2)Cl	IC50 ~ 100000 nM	Poor binder
T43721	Corticosteroid 11-beta-dehydrogenase 2	BRX29U	(2R)-2-[(3R)-3-Fluoropyrrolidin-1-yl]-N-(5-hydroxy-2-adamantyl)propanamide	Investigative	25210659	C17H27FN2O2	310.4	C[C@H](C(=O)NC1C2CC3CC1CC(C3)(C2)O)N4CC[C@H](C4)F	IC50 ~ 100000 nM	Poor binder
T43721	Corticosteroid 11-beta-dehydrogenase 2	BSU9F5	2-(4-Chloro-phenoxy)-2-methyl-N-(5-methylsulfamoyl-adamantan-2-yl)-propionamide	Investigative	11626362	C21H29ClN2O4S	441	CC(C)(C(=O)NC1C2CC3CC1CC(C3)(C2)S(=O)(=O)NC)OC4=CC=C(C=C4)Cl	IC50 = 85000 nM	Poor binder
T43721	Corticosteroid 11-beta-dehydrogenase 2	BT57XP	CID 49846838	Investigative	49846838	C21H20F7N3O4S	543.5	C[C@@H]1CN(CCN1S(=O)(=O)C2=CC=CC(=C2)[C@@](C(=O)N)(C(F)(F)F)O)C3=C(C=C(C=C3)F)C(F)(F)F	IC50 ~ 100000 nM	Poor binder
T43721	Corticosteroid 11-beta-dehydrogenase 2	BT5PU4	2-(4-Chloro-phenoxy)-2-methyl-N-[(1S,2S,5R,7S)-5-(1H-tetrazol-5-ylmethyl)-adamantan-2-yl]-propionamide	Investigative	44418384	C22H28ClN5O2	429.9	CC(C)(C(=O)NC1[C@H]2CC3CC1CC(C2)(C3)CC4=NNN=N4)OC5=CC=C(C=C5)Cl	IC50 ~ 100000 nM	Poor binder
T43721	Corticosteroid 11-beta-dehydrogenase 2	BTKU08	4-(2-Methyl-2-(4-(5-(trifluoromethyl)pyridin-2-yl)piperazin-1-yl)propanamido)bicyclo[2.2.2]octane-1-carboxamide	Investigative	44418456	C23H32F3N5O2	467.5	CC(C)(C(=O)NC12CCC(CC1)(CC2)C(=O)N)N3CCN(CC3)C4=NC=C(C=C4)C(F)(F)F	IC50 = 90000 nM	Poor binder
T43721	Corticosteroid 11-beta-dehydrogenase 2	BU7R1D	(1R,4S,5R,9R,10S,11S,13R,15R)-15-Hydroxy-5,9-dimethyl-14-methylidene-11-methylsulfanylcarbothioyloxytetracyclo[11.2.1.01,10.04,9]hexadecane-5-carboxylic acid	Investigative	73356629	C22H32O4S2	424.6	C[C@@]12CCC[C@@]([C@H]1CC[C@]34[C@H]2[C@H](C[C@@H](C3)C(=C)[C@H]4O)OC(=S)SC)(C)C(=O)O	IC50 ~ 100000 nM	Poor binder
T43721	Corticosteroid 11-beta-dehydrogenase 2	BV47SH	4-[3,3-Dimethyl-2-oxo-4-(5-trifluoromethyl-pyridin-2-yloxymethyl)-pyrrolidin-1-yl]-adamantane-1-carboxamidine	Investigative	24890073	C24H31F3N4O2	464.5	CC1(C(CN(C1=O)C2C3CC4CC2CC(C4)(C3)C(=N)N)COC5=NC=C(C=C5)C(F)(F)F)C	IC50 = 90000 nM	Poor binder
T43721	Corticosteroid 11-beta-dehydrogenase 2	BW8KU3	2-Methyl-2-phenoxy-N-(5-sulfamoyl-adamantan-2-yl)-propionamide	Investigative	44438679	C20H28N2O4S	392.5	CC(C)(C(=O)NC1C2CC3CC1CC(C3)(C2)S(=O)(=O)N)OC4=CC=CC=C4	IC50 = 59000 nM	Poor binder
T43721	Corticosteroid 11-beta-dehydrogenase 2	BXGT92	Spiro-carboxamide scaffold, 3	Investigative	44143289	C22H22ClNO	351.9	C1CC2(CCN(C2)C(=O)C3(CC3)C4=CC=C(C=C4)Cl)C5=CC=CC=C51	IC50 ~ 100000 nM	Poor binder
T43721	Corticosteroid 11-beta-dehydrogenase 2	BXVM06	2-(4-Fluoro-2-methoxy-phenoxy)-N-(5-methanesulfonyl-adamantan-2-yl)-2-methyl-propionamide	Investigative	44438677	C22H30FNO5S	439.5	CC(C)(C(=O)NC1C2CC3CC1CC(C3)(C2)S(=O)(=O)C)OC4=C(C=C(C=C4)F)OC	IC50 ~ 100000 nM	Poor binder
T43721	Corticosteroid 11-beta-dehydrogenase 2	BZSG56	1-Piperidin-1-yl-cyclopropanecarboxylic acid (5-hydroxy-adamantan-2-yl)-amide	Investigative	11666874	C19H30N2O2	318.5	C1CCN(CC1)C2(CC2)C(=O)NC3C4CC5CC3CC(C5)(C4)O	IC50 ~ 100000 nM	Poor binder
T43721	Corticosteroid 11-beta-dehydrogenase 2	BZU90G	HSD Inhibitor 23	Investigative	11634114	C24H33F3N4O2	466.5	CC(C)(C(=O)NC1C2CC3CC1CC(C3)(C2)O)N4CCN(CC4)C5=NC=C(C=C5)C(F)(F)F	IC50 ~ 100000 nM	Poor binder