TTD_Target_ID	Target_Name	TTD_Drug_ID	Drug_Name	Drug_Highest_Status	Drug_PubchemID	Molecular_Formula	Molecular_Weight	Canonical_SMILES	Activity	Binder_Type
T44011	Estradiol 17 beta-dehydrogenase 1	B08PNU	N,3-Bis(3-methoxyphenyl)-N-methylbenzamide	Investigative	60197921	C22H21NO3	347.4	CN(C1=CC(=CC=C1)OC)C(=O)C2=CC=CC(=C2)C3=CC(=CC=C3)OC	IC50 ~ 60000 nM	Poor binder
T44011	Estradiol 17 beta-dehydrogenase 1	B4ASY3	N-[(3-Hydroxyphenyl)methyl]-N-methyl-4-(3-methylphenyl)benzamide	Investigative	56933898	C22H21NO2	331.4	CC1=CC(=CC=C1)C2=CC=C(C=C2)C(=O)N(C)CC3=CC(=CC=C3)O	IC50 = 64532 nM	Poor binder
T44011	Estradiol 17 beta-dehydrogenase 1	B5EM2U	5-(3-Methoxyphenyl)-N-[(3-methoxyphenyl)methyl]-N-methylthiophene-2-carboxamide	Investigative	56934037	C21H21NO3S	367.5	CN(CC1=CC(=CC=C1)OC)C(=O)C2=CC=C(S2)C3=CC(=CC=C3)OC	IC50 ~ 100000 nM	Poor binder
T44011	Estradiol 17 beta-dehydrogenase 1	B6A9UV	4-(4-Chlorophenyl)-N-(3-methoxyphenyl)-N-methylcyclohexane-1-carboxamide	Investigative	127042310	C21H24ClNO2	357.9	CN(C1=CC(=CC=C1)OC)C(=O)C2CCC(CC2)C3=CC=C(C=C3)Cl	IC50 = 60100 nM	Poor binder
T44011	Estradiol 17 beta-dehydrogenase 1	B74BYI	4-Cyclopentyl-N-(5-hydroxy-2-adamantyl)-2-[[(3S)-oxolan-3-yl]amino]pyrimidine-5-carboxamide	Investigative	52911994	C24H34N4O3	426.6	C1CCC(C1)C2=NC(=NC=C2C(=O)NC3C4CC5CC3CC(C5)(C4)O)N[C@H]6CCOC6	IC50 ~ 100000 nM	Poor binder
T44011	Estradiol 17 beta-dehydrogenase 1	B7BE1N	N-Benzyl-5-(2-hydroxyphenyl)-N-methylthiophene-2-carboxamide	Investigative	56934188	C19H17NO2S	323.4	CN(CC1=CC=CC=C1)C(=O)C2=CC=C(S2)C3=CC=CC=C3O	IC50 ~ 100000 nM	Poor binder
T44011	Estradiol 17 beta-dehydrogenase 1	B7DR6G	N-Benzyl-5-(2-methoxyphenyl)-N-methylthiophene-2-carboxamide	Investigative	56934187	C20H19NO2S	337.4	CN(CC1=CC=CC=C1)C(=O)C2=CC=C(S2)C3=CC=CC=C3OC	IC50 = 55741 nM	Poor binder
T44011	Estradiol 17 beta-dehydrogenase 1	B8FKJ6	(7S)-7-Methyl-7-(4,4,4-trifluoro-1-hydroxybut-2-ynyl)-5,6,8,8a,9,10-hexahydro-4bH-phenanthren-2-ol	Investigative	44314270	C19H21F3O2	338.4	C[C@@]1(CCC2C(C1)CCC3=C2C=CC(=C3)O)C(C#CC(F)(F)F)O	Ki = 59000 nM	Poor binder
T44011	Estradiol 17 beta-dehydrogenase 1	B9HJR7	N-Benzyl-5-(3-methoxyphenyl)-N-methylthiophene-2-carboxamide	Investigative	56934183	C20H19NO2S	337.4	CN(CC1=CC=CC=C1)C(=O)C2=CC=C(S2)C3=CC(=CC=C3)OC	IC50 ~ 100000 nM	Poor binder
T44011	Estradiol 17 beta-dehydrogenase 1	BEKS27	5-(2-Fluoro-3-methoxyphenyl)-N-(3-methoxyphenyl)-N-methylthiophene-2-carboxamide	Investigative	60165269	C20H18FNO3S	371.4	CN(C1=CC(=CC=C1)OC)C(=O)C2=CC=C(S2)C3=C(C(=CC=C3)OC)F	IC50 ~ 50000 nM	Poor binder
T44011	Estradiol 17 beta-dehydrogenase 1	BF6YC0	(7R)-7-Methyl-7-(4,4,4-trifluoro-1-hydroxybut-2-ynyl)-5,6,8,8a,9,10-hexahydro-4bH-phenanthren-2-ol	Investigative	44314513	C19H21F3O2	338.4	C[C@]1(CCC2C(C1)CCC3=C2C=CC(=C3)O)C(C#CC(F)(F)F)O	Ki = 65000 nM	Poor binder
T44011	Estradiol 17 beta-dehydrogenase 1	BFM4Z9	N-Benzyl-5-(4-methoxyphenyl)-N-methylthiophene-2-carboxamide	Investigative	56934185	C20H19NO2S	337.4	CN(CC1=CC=CC=C1)C(=O)C2=CC=C(S2)C3=CC=C(C=C3)OC	IC50 ~ 100000 nM	Poor binder
T44011	Estradiol 17 beta-dehydrogenase 1	BJ2U1A	N-(3-Methoxybenzyl)-N,3'-dimethylbiphenyl-4-carboxamide	Investigative	56933897	C23H23NO2	345.4	CC1=CC(=CC=C1)C2=CC=C(C=C2)C(=O)N(C)CC3=CC(=CC=C3)OC	IC50 ~ 100000 nM	Poor binder
T44011	Estradiol 17 beta-dehydrogenase 1	BO2UB5	[6-(3-Chloro-4-hydroxyphenyl)pyridin-2-yl]-(3-hydroxyphenyl)methanone	Investigative	136042246	C18H12ClNO3	325.7	C1=CC(=CC(=C1)O)C(=O)C2=CC=CC(=N2)C3=CC(=C(C=C3)O)Cl	IC50 = 60638 nM	Poor binder
T44011	Estradiol 17 beta-dehydrogenase 1	BQD03V	5-(4-Methoxyphenyl)-N-[(3-methoxyphenyl)methyl]-N-methylthiophene-2-carboxamide	Investigative	56934039	C21H21NO3S	367.5	CN(CC1=CC(=CC=C1)OC)C(=O)C2=CC=C(S2)C3=CC=C(C=C3)OC	IC50 ~ 120000 nM	Poor binder
T44011	Estradiol 17 beta-dehydrogenase 1	BR9PD5	(1R,2S,9S,12S)-9-Methyl-7-oxa-6-azapentacyclo[10.8.0.02,9.04,8.013,18]icosa-4(8),5,13(18),14,16-pentaen-16-ol	Investigative	71450526	C19H21NO2	295.4	C[C@]12CC[C@H]3[C@H]([C@@H]1CC4=C2ON=C4)CCC5=C3C=CC(=C5)O	Ki = 69400 nM	Poor binder
T44011	Estradiol 17 beta-dehydrogenase 1	BUB1V0	3'-Methoxy-N-(3-methoxybenzyl)-N-methylbiphenyl-4-carboxamide	Investigative	56933761	C23H23NO3	361.4	CN(CC1=CC(=CC=C1)OC)C(=O)C2=CC=C(C=C2)C3=CC(=CC=C3)OC	IC50 ~ 100000 nM	Poor binder
T44011	Estradiol 17 beta-dehydrogenase 1	BUFX60	N-Cyclopropyl-5-(2-fluoro-3-methoxyphenyl)-N-(3-hydroxybenzyl)thiophene-2-carboxamide	Investigative	60197003	C22H20FNO3S	397.5	COC1=CC=CC(=C1F)C2=CC=C(S2)C(=O)N(CC3=CC(=CC=C3)O)C4CC4	IC50 = 85343 nM	Poor binder