TTD_Target_ID	Target_Name	TTD_Drug_ID	Drug_Name	Drug_Highest_Status	Drug_PubchemID	Molecular_Formula	Molecular_Weight	Canonical_SMILES	Activity	Binder_Type
T46515	Isoleucyl-tRNA synthetase	B08DSI	2-[(4-Hydroxy-3-methoxybenzoyl)amino]ethyl (2S)-2-amino-3-methylpentanoate	Investigative	44386211	C16H24N2O5	324.37	CCC(C)[C@@H](C(=O)OCCNC(=O)C1=CC(=C(C=C1)O)OC)N	IC50 = 64400 nM	Poor binder
T46515	Isoleucyl-tRNA synthetase	B19UIH	[(S)-2-Amino-3-(3H-imidazol-4-yl)-propionyl]-sulfamic acid (2R,3S,4R,5R)-3,4-dihydroxy-5-(4-phenyl-thiazol-2-yl)-tetrahydro-furan-2-ylmethyl ester	Investigative	44349189	C20H23N5O7S2	509.6	C1=CC=C(C=C1)C2=CSC(=N2)[C@H]3[C@@H]([C@@H]([C@H](O3)COS(=O)(=O)NC(=O)[C@H](CC4=CN=CN4)N)O)O	IC50 ~ 100000 nM	Poor binder
T46515	Isoleucyl-tRNA synthetase	B1VO7B	[3-(4-Hydroxy-3-methoxyphenyl)-4,5-dihydro-1,2-oxazol-5-yl]methyl (2S)-2-amino-3-methylpentanoate	Investigative	135995968	C17H24N2O5	336.4	CCC(C)[C@@H](C(=O)OCC1CC(=NO1)C2=CC(=C(C=C2)O)OC)N	IC50 = 79000 nM	Poor binder
T46515	Isoleucyl-tRNA synthetase	B3EUP6	(2S,3S)-2-Amino-N-[[(2R,3S,4R,5S)-5-[2-[6-(benzylamino)purin-9-yl]ethyl]-3,4-dihydroxyoxolan-2-yl]methyl]-N-hydroxy-3-methylpentanamide	Investigative	44384945	C25H35N7O5	513.6	CC[C@H](C)[C@@H](C(=O)N(C[C@@H]1[C@H]([C@H]([C@@H](O1)CCN2C=NC3=C(N=CN=C32)NCC4=CC=CC=C4)O)O)O)N	IC50 ~ 128000 nM	Poor binder
T46515	Isoleucyl-tRNA synthetase	B4V9EB	[(2R,3S,4R,5S)-5-[2-[6-(Benzylamino)purin-9-yl]ethyl]-3,4-dihydroxyoxolan-2-yl]methyl (2S,3S)-2-amino-3-methylpentanoate	Investigative	44384821	C25H34N6O5	498.6	CC[C@H](C)[C@@H](C(=O)OC[C@@H]1[C@H]([C@H]([C@@H](O1)CCN2C=NC3=C(N=CN=C32)NCC4=CC=CC=C4)O)O)N	IC50 = 84000 nM	Poor binder
T46515	Isoleucyl-tRNA synthetase	B4XM8Q	[(2R,3S,4R,5S)-5-[(6-Aminopurin-9-yl)methyl]-3,4-dihydroxyoxolan-2-yl]methyl (2S,3S)-2-amino-3-methylpentanoate	Investigative	44385414	C17H26N6O5	394.4	CC[C@H](C)[C@@H](C(=O)OC[C@@H]1[C@H]([C@H]([C@@H](O1)CN2C=NC3=C(N=CN=C32)N)O)O)N	IC50 ~ 128000 nM	Poor binder
T46515	Isoleucyl-tRNA synthetase	B5EA4Y	((S)-2-Amino-propionyl)-sulfamic acid (2R,3S,4R,5R)-3,4-dihydroxy-5-(4-phenyl-thiazol-2-yl)-tetrahydro-furan-2-ylmethyl ester	Investigative	44349104	C17H21N3O7S2	443.5	C[C@@H](C(=O)NS(=O)(=O)OC[C@@H]1[C@H]([C@H]([C@@H](O1)C2=NC(=CS2)C3=CC=CC=C3)O)O)N	IC50 = 100000 nM	Poor binder
T46515	Isoleucyl-tRNA synthetase	B69MZH	(2S,3S)-2-Amino-N-[[(2R,3S,4R,5S)-3,4-dihydroxy-5-[2-(5-phenyltetrazol-2-yl)ethyl]oxolan-2-yl]methyl]-N-hydroxy-3-methylpentanamide	Investigative	44384778	C20H30N6O5	434.5	CC[C@H](C)[C@@H](C(=O)N(C[C@@H]1[C@H]([C@H]([C@@H](O1)CCN2N=C(N=N2)C3=CC=CC=C3)O)O)O)N	IC50 ~ 128000 nM	Poor binder
T46515	Isoleucyl-tRNA synthetase	B7J0GI	L-Isoleucine 5'-adenosyl ester	Investigative	44385960	C16H24N6O5	380.4	CC[C@H](C)[C@@H](C(=O)OC[C@@H]1[C@H]([C@H]([C@@H](O1)N2C=NC3=C(N=CN=C32)N)O)O)N	IC50 = 183000 nM	Poor binder
T46515	Isoleucyl-tRNA synthetase	B7J3IN	2-[(3-Hydroxy-4-methoxybenzoyl)amino]ethyl (2S)-2-amino-3-methylpentanoate	Investigative	44385851	C16H24N2O5	324.37	CCC(C)[C@@H](C(=O)OCCNC(=O)C1=CC(=C(C=C1)OC)O)N	IC50 = 106000 nM	Poor binder
T46515	Isoleucyl-tRNA synthetase	B7ZP4G	[(2R,3S,4R,5S)-5-[2-(6-Aminopurin-9-yl)ethyl]-3,4-dihydroxyoxolan-2-yl]methyl (2S,3S)-2-amino-3-methylpentanoate	Investigative	44384617	C18H28N6O5	408.5	CC[C@H](C)[C@@H](C(=O)OC[C@@H]1[C@H]([C@H]([C@@H](O1)CCN2C=NC3=C(N=CN=C32)N)O)O)N	IC50 ~ 128000 nM	Poor binder
T46515	Isoleucyl-tRNA synthetase	BD56OI	((S)-2-Amino-3-phenyl-propionyl)-sulfamic acid (2R,3S,4R,5R)-3,4-dihydroxy-5-(4-phenyl-thiazol-2-yl)-tetrahydro-furan-2-ylmethyl ester	Investigative	44349092	C23H25N3O7S2	519.6	C1=CC=C(C=C1)C[C@@H](C(=O)NS(=O)(=O)OC[C@@H]2[C@H]([C@H]([C@@H](O2)C3=NC(=CS3)C4=CC=CC=C4)O)O)N	IC50 ~ 100000 nM	Poor binder
T46515	Isoleucyl-tRNA synthetase	BE20MF	[3-(3-Hydroxy-4-methoxyphenyl)-4,5-dihydro-1,2-oxazol-5-yl]methyl (2S)-2-amino-3-methylpentanoate	Investigative	44385230	C17H24N2O5	336.4	CCC(C)[C@@H](C(=O)OCC1CC(=NO1)C2=CC(=C(C=C2)OC)O)N	IC50 = 57600 nM	Poor binder
T46515	Isoleucyl-tRNA synthetase	BGK9N1	(2S,3S)-2-Amino-N-[[(2R,3S,4R)-5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl-hydroxysulfamoyl]-3-methylpentanamide	Investigative	46874938	C16H26N8O7S	474.5	CC[C@H](C)[C@@H](C(=O)NS(=O)(=O)N(C[C@@H]1[C@H]([C@H](C(O1)N2C=NC3=C(N=CN=C32)N)O)O)O)N	IC50 = 132000 nM	Poor binder
T46515	Isoleucyl-tRNA synthetase	BP92LX	N-(5'-Adenosyl)-N-hydroxy-L-isoleucinamide	Investigative	44384563	C16H25N7O5	395.41	CC[C@H](C)[C@@H](C(=O)N(C[C@@H]1[C@H]([C@H]([C@@H](O1)N2C=NC3=C(N=CN=C32)N)O)O)O)N	IC50 = 181000 nM	Poor binder
T46515	Isoleucyl-tRNA synthetase	BS6ZG5	(2S,3S)-2-Amino-N-[[(2R,3S,4R,5S)-5-[2-(6-aminopurin-9-yl)ethyl]-3,4-dihydroxyoxolan-2-yl]methyl]-N-hydroxy-3-methylpentanamide	Investigative	44384623	C18H29N7O5	423.5	CC[C@H](C)[C@@H](C(=O)N(C[C@@H]1[C@H]([C@H]([C@@H](O1)CCN2C=NC3=C(N=CN=C32)N)O)O)O)N	IC50 ~ 128000 nM	Poor binder
T46515	Isoleucyl-tRNA synthetase	BUWJ51	2-[[2-(3-Hydroxy-4-methoxyphenyl)acetyl]amino]ethyl (2S)-2-amino-3-methylpentanoate	Investigative	44386110	C17H26N2O5	338.4	CCC(C)[C@@H](C(=O)OCCNC(=O)CC1=CC(=C(C=C1)OC)O)N	IC50 = 56500 nM	Poor binder
T46515	Isoleucyl-tRNA synthetase	BV1FL7	(2S,3S)-2-Amino-N-[[(2R,3S,4R,5S)-5-[(6-aminopurin-9-yl)methyl]-3,4-dihydroxyoxolan-2-yl]methyl]-N-hydroxy-3-methylpentanamide	Investigative	44386149	C17H27N7O5	409.4	CC[C@H](C)[C@@H](C(=O)N(C[C@@H]1[C@H]([C@H]([C@@H](O1)CN2C=NC3=C(N=CN=C32)N)O)O)O)N	IC50 ~ 128000 nM	Poor binder
T46515	Isoleucyl-tRNA synthetase	BV56NA	[(4R)-2-(4-Hydroxy-3-methoxyphenyl)-4,5-dihydro-1,3-oxazol-4-yl]methyl (2S)-2-amino-3-methylpentanoate	Investigative	135995964	C17H24N2O5	336.4	CCC(C)[C@@H](C(=O)OC[C@H]1COC(=N1)C2=CC(=C(C=C2)O)OC)N	IC50 = 50000 nM	Poor binder
T46515	Isoleucyl-tRNA synthetase	BYK1H4	[(2R,3S,4R,5S)-3,4-Dihydroxy-5-[2-(5-phenyltetrazol-2-yl)ethyl]oxolan-2-yl]methyl (2S,3S)-2-amino-3-methylpentanoate	Investigative	44386065	C20H29N5O5	419.5	CC[C@H](C)[C@@H](C(=O)OC[C@@H]1[C@H]([C@H]([C@@H](O1)CCN2N=C(N=N2)C3=CC=CC=C3)O)O)N	IC50 = 63600 nM	Poor binder