TTD_Target_ID	Target_Name	TTD_Drug_ID	Drug_Name	Drug_Highest_Status	Drug_PubchemID	Molecular_Formula	Molecular_Weight	Canonical_SMILES	Activity	Binder_Type
T46781	Aurora kinase B	D00FGR	Miltefosine	Approved	3599	C21H46NO4P	407.6	CCCCCCCCCCCCCCCCOP(=O)([O-])OCC[N+](C)(C)C	IC50 ~ 100000 nM	Poor binder
T46781	Aurora kinase B	D04XGT	Benznidazole	Approved	31593	C12H12N4O3	260.25	C1=CC=C(C=C1)CNC(=O)CN2C=CN=C2[N+](=O)[O-]	IC50 ~ 100000 nM	Poor binder
T46781	Aurora kinase B	D05EAM	Pentamidine	Approved	4735	C19H24N4O2	340.4	C1=CC(=CC=C1C(=N)N)OCCCCCOC2=CC=C(C=C2)C(=N)N	IC50 ~ 100000 nM	Poor binder
T46781	Aurora kinase B	B0P4NS	2-(2,5-Difluorobenzyl)-4-(5-methyl-1H-pyrazol-3-ylamino)phthalazin-1(2H)-one	Investigative	11667761	C19H15F2N5O	367.4	CC1=CC(=NN1)NC2=NN(C(=O)C3=CC=CC=C32)CC4=C(C=CC(=C4)F)F	IC50 ~ 100000 nM	Poor binder
T46781	Aurora kinase B	B13UPZ	2-(6-Amino-9H-purine-9-yl)-1-(1H-indole-3-yl)ethanone	Investigative	42603880	C15H12N6O	292.3	C1=CC=C2C(=C1)C(=CN2)C(=O)CN3C=NC4=C(N=CN=C43)N	IC50 = 69000 nM	Poor binder
T46781	Aurora kinase B	B19QML	2-Benzyl-4-[(5-methyl-1H-pyrazol-3-yl)amino]phthalazin-1-one	Investigative	11587983	C19H17N5O	331.4	CC1=CC(=NN1)NC2=NN(C(=O)C3=CC=CC=C32)CC4=CC=CC=C4	IC50 ~ 100000 nM	Poor binder
T46781	Aurora kinase B	B1A4EI	(8S,16S)-3,16-Dihydroxy-9,10-seco-1,3,5(10)-cholestatrien-9-one	Investigative	9547398	C27H42O3	414.6	CC1=C(C=C(C=C1)O)CC[C@H]2[C@@H]3C[C@@H]([C@@H]([C@]3(CCC2=O)C)[C@H](C)CCCC(C)C)O	IC50 ~ 100000 nM	Poor binder
T46781	Aurora kinase B	B1TDK2	Tert-butyl N-[(2R)-1-[[4-(3-bromoanilino)quinazolin-6-yl]amino]-4-methylsulfanyl-1-oxobutan-2-yl]carbamate	Investigative	137649033	C24H28BrN5O3S	546.5	CC(C)(C)OC(=O)N[C@H](CCSC)C(=O)NC1=CC2=C(C=C1)N=CN=C2NC3=CC(=CC=C3)Br	IC50 ~ 100000 nM	Poor binder
T46781	Aurora kinase B	B1VO9R	Calicoferol E	Investigative	5283685	C27H42O2	398.6	CC1=C(C=C(C=C1)O)CC[C@H]2[C@@H]3CC[C@@H]([C@]3(CCC2=O)C)[C@H](C)CCCC(C)C	IC50 ~ 100000 nM	Poor binder
T46781	Aurora kinase B	B2EX3Y	4-(1-Methylbenzimidazol-2-yl)-N-(4-methylphenyl)pyrimidin-2-amine	Investigative	60165994	C19H17N5	315.4	CC1=CC=C(C=C1)NC2=NC=CC(=N2)C3=NC4=CC=CC=C4N3C	IC50 ~ 100000 nM	Poor binder
T46781	Aurora kinase B	B2JVZ9	Tert-butyl N-[(2R)-1-[[4-(3-bromoanilino)quinazolin-6-yl]amino]-1-oxopropan-2-yl]carbamate	Investigative	137648629	C22H24BrN5O3	486.4	C[C@H](C(=O)NC1=CC2=C(C=C1)N=CN=C2NC3=CC(=CC=C3)Br)NC(=O)OC(C)(C)C	IC50 ~ 100000 nM	Poor binder
T46781	Aurora kinase B	B2LQ0P	Clc1ccc(NC(=O)Nc2ccc(COc3ccc4nc(NCCN5CCOCC5)oc4c3)cc2)cc1	Investigative	127044457	C27H28ClN5O4	522	C1COCCN1CCNC2=NC3=C(O2)C=C(C=C3)OCC4=CC=C(C=C4)NC(=O)NC5=CC=C(C=C5)Cl	IC50 = 50400 nM	Poor binder
T46781	Aurora kinase B	B30DQK	7-Iodoindirubin-3-acetoxime	Investigative	136104464	C18H12IN3O3	445.2	CC(=O)O/N=C\\1/C2=CC=CC=C2N=C1C3=C(NC4=C3C=CC=C4I)O	IC50 ~ 100000 nM	Poor binder
T46781	Aurora kinase B	B30PTF	4-(5-Methyl-1H-pyrazol-3-ylamino)-2-(2-oxo-2-phenylethyl)phthalazin-1(2H)-one	Investigative	21106492	C20H17N5O2	359.4	CC1=CC(=NN1)NC2=NN(C(=O)C3=CC=CC=C32)CC(=O)C4=CC=CC=C4	IC50 ~ 100000 nM	Poor binder
T46781	Aurora kinase B	B35CDQ	7-Chloroindirubin-3-acetoxime	Investigative	136104462	C18H12ClN3O3	353.8	CC(=O)O/N=C\\1/C2=CC=CC=C2N=C1C3=C(NC4=C3C=CC=C4Cl)O	IC50 ~ 100000 nM	Poor binder
T46781	Aurora kinase B	B3CSZ2	N-(2-Chloro-4-methoxyphenyl)-2-(1H-pyrazol-4-yl)-1H-pyrrolo[3,2-c]pyridin-6-amine	Investigative	68291028	C17H14ClN5O	339.8	COC1=CC(=C(C=C1)NC2=NC=C3C=C(NC3=C2)C4=CNN=C4)Cl	IC50 ~ 100000 nM	Poor binder
T46781	Aurora kinase B	B3KPB9	7-Bromoindirubin	Investigative	135423783	C16H9BrN2O2	341.16	C1=CC=C2C(=C1)C(=O)C(=N2)C3=C(NC4=C3C=CC=C4Br)O	IC50 ~ 100000 nM	Poor binder
T46781	Aurora kinase B	B3LYC9	4-(1-Methylbenzimidazol-2-yl)-N-(4-morpholin-4-ylphenyl)pyrimidin-2-amine	Investigative	60166135	C22H22N6O	386.4	CN1C2=CC=CC=C2N=C1C3=NC(=NC=C3)NC4=CC=C(C=C4)N5CCOCC5	IC50 ~ 100000 nM	Poor binder
T46781	Aurora kinase B	B3T9QN	Methyl 4-(6-(4-(methoxycarbonylamino)phenyl)-4-morpholino-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidine-1-carboxylate	Investigative	44219749	C24H29N7O5	495.5	COC(=O)NC1=CC=C(C=C1)C2=NC3=C(C=NN3C4CCN(CC4)C(=O)OC)C(=N2)N5CCOCC5	IC50 ~ 50000 nM	Poor binder
T46781	Aurora kinase B	B3Z2PX	7-Iodoindirubin-3-methoxime	Investigative	136104469	C17H12IN3O2	417.2	CO/N=C\\1/C2=CC=CC=C2N=C1C3=C(NC4=C3C=CC=C4I)O	IC50 ~ 100000 nM	Poor binder
T46781	Aurora kinase B	B4G2QZ	Methyl 4-(6-(4-aminophenyl)-4-morpholino-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidine-1-carboxylate	Investigative	44605035	C22H27N7O3	437.5	COC(=O)N1CCC(CC1)N2C3=C(C=N2)C(=NC(=N3)C4=CC=C(C=C4)N)N5CCOCC5	IC50 ~ 50000 nM	Poor binder
T46781	Aurora kinase B	B4JC3D	N-(2,4-Dimethoxyphenyl)-2-[1-methyl-3-(trifluoromethyl)pyrazol-4-yl]-1H-pyrrolo[3,2-c]pyridin-6-amine	Investigative	76335739	C20H18F3N5O2	417.4	CN1C=C(C(=N1)C(F)(F)F)C2=CC3=CN=C(C=C3N2)NC4=C(C=C(C=C4)OC)OC	IC50 ~ 100000 nM	Poor binder
T46781	Aurora kinase B	B4MB3O	2-(3-Methylphenyl)-4-[(5-methyl-1H-pyrazol-3-yl)amino]phthalazin-1-one	Investigative	11645638	C19H17N5O	331.4	CC1=CC(=CC=C1)N2C(=O)C3=CC=CC=C3C(=N2)NC4=NNC(=C4)C	IC50 ~ 100000 nM	Poor binder
T46781	Aurora kinase B	B4MDR2	Tert-butyl N-[(2R)-4-methylsulfanyl-1-oxo-1-[[4-[3-(trifluoromethyl)anilino]quinazolin-6-yl]amino]butan-2-yl]carbamate	Investigative	137649545	C25H28F3N5O3S	535.6	CC(C)(C)OC(=O)N[C@H](CCSC)C(=O)NC1=CC2=C(C=C1)N=CN=C2NC3=CC=CC(=C3)C(F)(F)F	IC50 ~ 100000 nM	Poor binder
T46781	Aurora kinase B	B4YXC8	7-[[(1R,2S,4Ar,8aS)-1,2,4a,5-tetramethyl-2,3,4,7,8,8a-hexahydronaphthalen-1-yl]methyl]-5-methoxy-2-methyl-1,3-benzoxazol-6-ol	Investigative	76335685	C24H33NO3	383.5	C[C@H]1CC[C@@]2([C@H]([C@]1(C)CC3=C4C(=CC(=C3O)OC)N=C(O4)C)CCC=C2C)C	IC50 ~ 100000 nM	Poor binder
T46781	Aurora kinase B	B51ZTE	2-[(3,5-Difluorophenyl)methyl]-4-[(5-methyl-1H-pyrazol-3-yl)amino]phthalazin-1-one	Investigative	11603072	C19H15F2N5O	367.4	CC1=CC(=NN1)NC2=NN(C(=O)C3=CC=CC=C32)CC4=CC(=CC(=C4)F)F	IC50 ~ 100000 nM	Poor binder
T46781	Aurora kinase B	B57DPR	CID 66548650	Investigative	66548650	C19H16F3N5O	387.4	COC1=CC=CC=C1NC2=NC=C3C=C(NC3=C2)C4=CN(N=C4)CC(F)(F)F	IC50 ~ 100000 nM	Poor binder
T46781	Aurora kinase B	B5JKD1	N-(4-Chlorophenyl)-4-(1-methylbenzimidazol-2-yl)pyrimidin-2-amine	Investigative	60165995	C18H14ClN5	335.8	CN1C2=CC=CC=C2N=C1C3=NC(=NC=C3)NC4=CC=C(C=C4)Cl	IC50 ~ 100000 nM	Poor binder
T46781	Aurora kinase B	B5NSE7	4-(4-Methyl-1H-indol-5-ylamino)-5-(3-(4-methylpiperazin-1-ylsulfonyl)styryl)nicotinonitrile	Investigative	45375865	C28H28N6O2S	512.6	CC1=C(C=CC2=C1C=CN2)NC3=C(C=NC=C3/C=C/C4=CC(=CC=C4)S(=O)(=O)N5CCN(CC5)C)C#N	IC50 ~ 50000 nM	Poor binder
T46781	Aurora kinase B	B61HPW	3-Methoxy-N,N-dimethyl-4-[[2-(1-methylpyrazol-4-yl)-1H-pyrrolo[3,2-c]pyridin-6-yl]amino]benzamide	Investigative	68290592	C21H22N6O2	390.4	CN1C=C(C=N1)C2=CC3=CN=C(C=C3N2)NC4=C(C=C(C=C4)C(=O)N(C)C)OC	IC50 ~ 100000 nM	Poor binder
T46781	Aurora kinase B	B65WVG	N-(2-Methoxyphenyl)-2-(1-methyl-1H-pyrazole-4-yl)-1H-pyrrolo[3,2-c]pyridine-6-amine	Investigative	68290919	C18H17N5O	319.4	CN1C=C(C=N1)C2=CC3=CN=C(C=C3N2)NC4=CC=CC=C4OC	IC50 ~ 100000 nM	Poor binder
T46781	Aurora kinase B	B78XTR	Chembl4289343	Investigative	141483896	C18H14N6O2	346.3	CC1=CC(=NN1)NC2=NC(=NC3=C2C=CC(=C3)[N+](=O)[O-])C4=CC=CC=C4	IC50 ~ 100000 nM	Poor binder
T46781	Aurora kinase B	B7NT9G	N-(2-Methoxyphenyl)-2-(1H-pyrazole-4-yl)-1H-pyrrolo[3,2-c]pyridine-6-amine	Investigative	68291375	C17H15N5O	305.33	COC1=CC=CC=C1NC2=NC=C3C=C(NC3=C2)C4=CNN=C4	IC50 ~ 100000 nM	Poor binder
T46781	Aurora kinase B	B7VIZ5	Tert-butyl N-[(2R)-1-[[4-(3-chloro-4-fluoroanilino)quinazolin-6-yl]amino]-1-oxopropan-2-yl]carbamate	Investigative	134827836	C22H23ClFN5O3	459.9	C[C@H](C(=O)NC1=CC2=C(C=C1)N=CN=C2NC3=CC(=C(C=C3)F)Cl)NC(=O)OC(C)(C)C	IC50 ~ 100000 nM	Poor binder
T46781	Aurora kinase B	B8CA1J	7-Bromoindirubin-3-methoxime	Investigative	136104468	C17H12BrN3O2	370.2	CO/N=C\\1/C2=CC=CC=C2N=C1C3=C(NC4=C3C=CC=C4Br)O	IC50 ~ 100000 nM	Poor binder
T46781	Aurora kinase B	B97XCE	Tert-butyl N-[2-[[4-(2,6-dimethylanilino)quinazolin-6-yl]amino]-2-oxoethyl]carbamate	Investigative	137634130	C23H27N5O3	421.5	CC1=C(C(=CC=C1)C)NC2=NC=NC3=C2C=C(C=C3)NC(=O)CNC(=O)OC(C)(C)C	IC50 ~ 100000 nM	Poor binder
T46781	Aurora kinase B	B9AGZ0	2-[2-(3-Methoxyphenyl)-2-oxoethyl]-4-(5-methyl-1H-pyrazol-3-ylamino)-2H-phthalazin-1-one	Investigative	21106464	C21H19N5O3	389.4	CC1=CC(=NN1)NC2=NN(C(=O)C3=CC=CC=C32)CC(=O)C4=CC(=CC=C4)OC	IC50 = 67000 nM	Poor binder
T46781	Aurora kinase B	BA62QX	4-(4-Methyl-1H-indol-5-ylamino)-2-(3-oxo-3-(pyrrolidin-1-yl)prop-1-enyl)thieno[2,3-b]pyridine-5-carbonitrile	Investigative	24766030	C24H21N5OS	427.5	CC1=C(C=CC2=C1C=CN2)NC3=C4C=C(SC4=NC=C3C#N)/C=C/C(=O)N5CCCC5	IC50 ~ 50000 nM	Poor binder
T46781	Aurora kinase B	BAJO26	4-(1h-Pyrazol-3-ylamino)-2-p-tolyl-2h-phthalazin-1-one	Investigative	11681497	C19H17N5O	331.4	CC1=CC=C(C=C1)N2C(=O)C3=CC=CC=C3C(=N2)NC4=NNC(=C4)C	IC50 ~ 100000 nM	Poor binder
T46781	Aurora kinase B	BB4PY9	Tert-butyl N-[(2R)-1-[[4-(3-chloro-4-fluoroanilino)quinazolin-6-yl]amino]-4-methyl-1-oxopentan-2-yl]carbamate	Investigative	134827837	C25H29ClFN5O3	502	CC(C)C[C@H](C(=O)NC1=CC2=C(C=C1)N=CN=C2NC3=CC(=C(C=C3)F)Cl)NC(=O)OC(C)(C)C	IC50 ~ 100000 nM	Poor binder
T46781	Aurora kinase B	BC3H1K	N-(2-Ethoxyphenyl)-2-(1H-pyrazol-4-yl)-1H-pyrrolo[3,2-c]pyridin-6-amine	Investigative	66548850	C18H17N5O	319.4	CCOC1=CC=CC=C1NC2=NC=C3C=C(NC3=C2)C4=CNN=C4	IC50 ~ 100000 nM	Poor binder
T46781	Aurora kinase B	BC6T4R	2-[1-(Difluoromethyl)pyrazol-4-yl]-N-(2-methoxyphenyl)-1H-pyrrolo[3,2-c]pyridin-6-amine	Investigative	66548653	C18H15F2N5O	355.3	COC1=CC=CC=C1NC2=NC=C3C=C(NC3=C2)C4=CN(N=C4)C(F)F	IC50 ~ 100000 nM	Poor binder
T46781	Aurora kinase B	BDB5P1	Chembl4276766	Investigative	145984157	C31H36N6O5	572.7	CC1=CC(=NN1)NC2=NC(=NC3=C2C=CC(=C3)N4CCC(CC4)C(=O)OC(C)(C)C)C(=O)C5=C(C=CC=C5OC)OC	IC50 ~ 60000 nM	Poor binder
T46781	Aurora kinase B	BDJ35Q	2-[9-(4-Amino-3-methoxyphenyl)-6-oxo-5,11-dihydrobenzo[b][1,4]benzodiazepin-3-yl]-2-methyl-N-(4-morpholin-4-ylphenyl)propanamide	Investigative	44427519	C34H35N5O4	577.7	CC(C)(C1=CC2=C(C=C1)NC3=C(C=CC(=C3)C4=CC(=C(C=C4)N)OC)C(=O)N2)C(=O)NC5=CC=C(C=C5)N6CCOCC6	IC50 ~ 50000 nM	Poor binder
T46781	Aurora kinase B	BDK9R0	Calicoferol C	Investigative	10024683	C28H44O2	412.6	CC1=C(C=C(C=C1)O)CC[C@H]2[C@@H]3CC[C@@H]([C@]3(CC[C@H]2O)C)[C@H](C)CCC(=C)C(C)C	IC50 ~ 100000 nM	Poor binder
T46781	Aurora kinase B	BDLU43	2-(4-Fluorophenyl)-4-[(5-methyl-1H-pyrazol-3-yl)amino]phthalazin-1-one	Investigative	11624169	C18H14FN5O	335.3	CC1=CC(=NN1)NC2=NN(C(=O)C3=CC=CC=C32)C4=CC=C(C=C4)F	IC50 ~ 100000 nM	Poor binder
T46781	Aurora kinase B	BE46DN	7-Fluoroindirubin-3-methoxime	Investigative	136104467	C17H12FN3O2	309.29	CO/N=C\\1/C2=CC=CC=C2N=C1C3=C(NC4=C3C=CC=C4F)O	IC50 ~ 100000 nM	Poor binder
T46781	Aurora kinase B	BEQ7V4	2-(1,5-Dimethylpyrazol-4-yl)-N-(2-methoxyphenyl)-1H-pyrrolo[3,2-c]pyridin-6-amine	Investigative	76313985	C19H19N5O	333.4	CC1=C(C=NN1C)C2=CC3=CN=C(C=C3N2)NC4=CC=CC=C4OC	IC50 ~ 100000 nM	Poor binder
T46781	Aurora kinase B	BF2QI1	N-(2-Chlorophenyl)-4-[[2-[4-[2-(4-ethylpiperazin-1-yl)-2-oxoethyl]anilino]-5-fluoropyrimidin-4-yl]amino]benzamide	Investigative	44139710	C31H31ClFN7O2	588.1	CCN1CCN(CC1)C(=O)CC2=CC=C(C=C2)NC3=NC=C(C(=N3)NC4=CC=C(C=C4)C(=O)NC5=CC=CC=C5Cl)F	IC50 ~ 50000 nM	Poor binder
T46781	Aurora kinase B	BF32AR	Calicoferol B	Investigative	10047545	C27H44O3	416.6	CC1=C(C=C(C=C1)O)CC[C@@H]2[C@@H](CC[C@]3([C@H]2C[C@@H]([C@@H]3[C@H](C)CCCC(C)C)O)C)O	IC50 ~ 100000 nM	Poor binder
T46781	Aurora kinase B	BF73GC	2-(4-Chlorophenyl)-4-[(5-methyl-1H-pyrazol-3-yl)amino]phthalazin-1-one	Investigative	11617275	C18H14ClN5O	351.8	CC1=CC(=NN1)NC2=NN(C(=O)C3=CC=CC=C32)C4=CC=C(C=C4)Cl	IC50 ~ 100000 nM	Poor binder
T46781	Aurora kinase B	BFNL14	Chembl4282545	Investigative	145980665	C18H14ClN5	335.8	CC1=CC(=NN1)NC2=NC(=NC3=C2C=CC(=C3)Cl)C4=CC=CC=C4	IC50 ~ 100000 nM	Poor binder
T46781	Aurora kinase B	BG4X8P	Tert-butyl N-[(2R)-1-[[4-(3-chloro-4-fluoroanilino)quinazolin-6-yl]amino]-3-methyl-1-oxobutan-2-yl]carbamate	Investigative	137633742	C24H27ClFN5O3	488	CC(C)[C@H](C(=O)NC1=CC2=C(C=C1)N=CN=C2NC3=CC(=C(C=C3)F)Cl)NC(=O)OC(C)(C)C	IC50 ~ 100000 nM	Poor binder
T46781	Aurora kinase B	BG8I2U	Tert-butyl N-[(2R,3S)-1-[[4-(3-chloro-4-fluoroanilino)quinazolin-6-yl]amino]-3-methyl-1-oxopentan-2-yl]carbamate	Investigative	137640413	C25H29ClFN5O3	502	CC[C@H](C)[C@H](C(=O)NC1=CC2=C(C=C1)N=CN=C2NC3=CC(=C(C=C3)F)Cl)NC(=O)OC(C)(C)C	IC50 ~ 100000 nM	Poor binder
T46781	Aurora kinase B	BG9CY0	2-[2-(4-Methoxyphenyl)-2-oxoethyl]-4-(5-methyl-1H-pyrazol-3-ylamino)-2H-phthalazin-1-one	Investigative	11501979	C21H19N5O3	389.4	CC1=CC(=NN1)NC2=NN(C(=O)C3=CC=CC=C32)CC(=O)C4=CC=C(C=C4)OC	IC50 ~ 100000 nM	Poor binder
T46781	Aurora kinase B	BGB87F	2-[(4-Fluorophenyl)methyl]-4-[(5-methyl-1H-pyrazol-3-yl)amino]phthalazin-1-one	Investigative	11508531	C19H16FN5O	349.4	CC1=CC(=NN1)NC2=NN(C(=O)C3=CC=CC=C32)CC4=CC=C(C=C4)F	IC50 = 69000 nM	Poor binder
T46781	Aurora kinase B	BGN94P	7-Chloroindirubin	Investigative	135423851	C16H9ClN2O2	296.71	C1=CC=C2C(=C1)C(=O)C(=N2)C3=C(NC4=C3C=CC=C4Cl)O	IC50 ~ 100000 nM	Poor binder
T46781	Aurora kinase B	BHI65O	3-Chloro-N,N-dimethyl-4-[[2-(1-methylpyrazol-4-yl)-1H-pyrrolo[3,2-c]pyridin-6-yl]amino]benzenesulfonamide	Investigative	68291099	C19H19ClN6O2S	430.9	CN1C=C(C=N1)C2=CC3=CN=C(C=C3N2)NC4=C(C=C(C=C4)S(=O)(=O)N(C)C)Cl	IC50 ~ 100000 nM	Poor binder
T46781	Aurora kinase B	BHV6I3	4-(1-Methylbenzimidazol-2-yl)-N-phenylpyrimidin-2-amine	Investigative	60165993	C18H15N5	301.3	CN1C2=CC=CC=C2N=C1C3=NC(=NC=C3)NC4=CC=CC=C4	IC50 ~ 100000 nM	Poor binder
T46781	Aurora kinase B	BIKV80	3-[[2-(2-Fluorophenyl)pyridin-4-yl]amino]-4-[[(1R)-1-phenylethyl]amino]cyclobut-3-ene-1,2-dione	Investigative	44575073	C23H18FN3O2	387.4	C[C@H](C1=CC=CC=C1)NC2=C(C(=O)C2=O)NC3=CC(=NC=C3)C4=CC=CC=C4F	IC50 ~ 50000 nM	Poor binder
T46781	Aurora kinase B	BK2X9I	2-(4-Methoxyphenyl)-4-[(5-methyl-1H-pyrazol-3-yl)amino]phthalazin-1-one	Investigative	11537541	C19H17N5O2	347.4	CC1=CC(=NN1)NC2=NN(C(=O)C3=CC=CC=C32)C4=CC=C(C=C4)OC	IC50 ~ 100000 nM	Poor binder
T46781	Aurora kinase B	BKMO25	N-[2-Methoxy-5-(trifluoromethyl)phenyl]-2-(1-methylpyrazol-4-yl)-1H-pyrrolo[3,2-c]pyridin-6-amine	Investigative	76317532	C19H16F3N5O	387.4	CN1C=C(C=N1)C2=CC3=CN=C(C=C3N2)NC4=C(C=CC(=C4)C(F)(F)F)OC	IC50 ~ 100000 nM	Poor binder
T46781	Aurora kinase B	BL1WQ6	Chembl4285937	Investigative	145993303	C20H16ClN5O	377.8	CC1=CC=C(C=C1)C(=O)C2=NC3=C(C=CC(=C3)Cl)C(=N2)NC4=NNC(=C4)C	IC50 ~ 100000 nM	Poor binder
T46781	Aurora kinase B	BLT7V0	Methyl 3-[[2-hydroxy-5-[4-[[(5-methyl-1,2-oxazol-3-yl)amino]methyl]triazol-1-yl]benzoyl]amino]benzoate	Investigative	127031808	C22H20N6O5	448.4	CC1=CC(=NO1)NCC2=CN(N=N2)C3=CC(=C(C=C3)O)C(=O)NC4=CC=CC(=C4)C(=O)OC	IC50 = 54800 nM	Poor binder
T46781	Aurora kinase B	BLUE24	Abelcet	Investigative	118705500	C47H73NO17	924.1	C[C@H]1/C=C/C=C/C=C/C=C/C=C/C=C/C=C/[C@@H](C[C@H]2[C@@H]([C@H](C[C@](O2)(C[C@H](C[C@H]([C@@H](CC[C@H](C[C@H](CC(=O)O[C@H]([C@@H]([C@@H]1O)C)C)O)O)O)O)O)O)O)C(=O)O)O[C@H]3[C@H]([C@H]([C@@H]([C@H](O3)C)O)N)O	IC50 ~ 100000 nM	Poor binder
T46781	Aurora kinase B	BM69UH	CID 68290918	Investigative	68290918	C22H21ClN6O3S	485	CN1C=C(C=N1)C2=CC3=CN=C(C=C3N2)NC4=C(C=C(C=C4)C(=O)N5CCS(=O)(=O)CC5)Cl	IC50 ~ 100000 nM	Poor binder
T46781	Aurora kinase B	BMTS94	6-Methyl-4-(4-methyl-1H-indol-5-ylamino)-5-(3-(4-methylpiperazin-1-ylsulfonyl)styryl)nicotinonitrile	Investigative	45375866	C29H30N6O2S	526.7	CC1=C(C=CC2=C1C=CN2)NC3=C(C(=NC=C3C#N)C)/C=C/C4=CC(=CC=C4)S(=O)(=O)N5CCN(CC5)C	IC50 ~ 50000 nM	Poor binder
T46781	Aurora kinase B	BN84BI	N-(2-Chlorophenyl)-2-(1H-pyrazol-4-yl)-1H-pyrrolo[3,2-c]pyridin-6-amine	Investigative	76313984	C16H12ClN5	309.75	C1=CC=C(C(=C1)NC2=NC=C3C=C(NC3=C2)C4=CNN=C4)Cl	IC50 ~ 100000 nM	Poor binder
T46781	Aurora kinase B	BNQ1U5	Tert-butyl N-[(2R)-3-methyl-1-oxo-1-[[4-[3-(trifluoromethyl)anilino]quinazolin-6-yl]amino]butan-2-yl]carbamate	Investigative	137652990	C25H28F3N5O3	503.5	CC(C)[C@H](C(=O)NC1=CC2=C(C=C1)N=CN=C2NC3=CC=CC(=C3)C(F)(F)F)NC(=O)OC(C)(C)C	IC50 ~ 100000 nM	Poor binder
T46781	Aurora kinase B	BNTQ40	Tert-butyl N-[(2R)-1-[[4-(3-bromoanilino)quinazolin-6-yl]amino]-4-methyl-1-oxopentan-2-yl]carbamate	Investigative	137644944	C25H30BrN5O3	528.4	CC(C)C[C@H](C(=O)NC1=CC2=C(C=C1)N=CN=C2NC3=CC(=CC=C3)Br)NC(=O)OC(C)(C)C	IC50 ~ 100000 nM	Poor binder
T46781	Aurora kinase B	BNUQ61	7-Fluoroindirubin	Investigative	135423852	C16H9FN2O2	280.25	C1=CC=C2C(=C1)C(=O)C(=N2)C3=C(NC4=C3C=CC=C4F)O	IC50 ~ 100000 nM	Poor binder
T46781	Aurora kinase B	BP4ZK0	Tert-butyl N-[(2R,3S)-1-[[4-(3-bromoanilino)quinazolin-6-yl]amino]-3-methyl-1-oxopentan-2-yl]carbamate	Investigative	137636602	C25H30BrN5O3	528.4	CC[C@H](C)[C@H](C(=O)NC1=CC2=C(C=C1)N=CN=C2NC3=CC(=CC=C3)Br)NC(=O)OC(C)(C)C	IC50 ~ 100000 nM	Poor binder
T46781	Aurora kinase B	BQ2N5U	4-(5-Methyl-1H-pyrazol-3-ylamino)-2-[2-oxo-2-(4-trifluoromethylphenyl)ethyl]-2H-phthalazin-1-one	Investigative	21106491	C21H16F3N5O2	427.4	CC1=CC(=NN1)NC2=NN(C(=O)C3=CC=CC=C32)CC(=O)C4=CC=C(C=C4)C(F)(F)F	IC50 ~ 100000 nM	Poor binder
T46781	Aurora kinase B	BQ85PE	Tert-butyl N-[2-oxo-2-[[4-[3-(trifluoromethyl)anilino]quinazolin-6-yl]amino]ethyl]carbamate	Investigative	137646574	C22H22F3N5O3	461.4	CC(C)(C)OC(=O)NCC(=O)NC1=CC2=C(C=C1)N=CN=C2NC3=CC=CC(=C3)C(F)(F)F	IC50 = 51000 nM	Poor binder
T46781	Aurora kinase B	BQS51E	Calicoferol A	Investigative	9547698	C27H40O2	396.6	CC1=C(C=C(C=C1)O)CC[C@H]2[C@@H]3CC[C@@H]([C@]3(CCC2=O)C)[C@H](C)/C=C/CC(C)C	IC50 ~ 100000 nM	Poor binder
T46781	Aurora kinase B	BR41TG	N-[2-Chloro-4-(4-methoxypiperidinocarbonyl)phenyl]-2-(1-methyl-1H-pyrazole-4-yl)-1H-pyrrolo[3,2-c]pyridine-6-amine	Investigative	68290875	C24H25ClN6O2	464.9	CN1C=C(C=N1)C2=CC3=CN=C(C=C3N2)NC4=C(C=C(C=C4)C(=O)N5CCC(CC5)OC)Cl	IC50 ~ 100000 nM	Poor binder
T46781	Aurora kinase B	BRW6S0	2-(4-Tert-Butylphenyl)-4-(5-methyl-1H-pyrazol-3-ylamino)-2H-phthalazin-1-one	Investigative	11710518	C22H23N5O	373.5	CC1=CC(=NN1)NC2=NN(C(=O)C3=CC=CC=C32)C4=CC=C(C=C4)C(C)(C)C	IC50 ~ 50000 nM	Poor binder
T46781	Aurora kinase B	BSI6U9	Tert-butyl N-[(2R)-1-[[4-(3-chloro-4-fluoroanilino)quinazolin-6-yl]amino]-4-methylsulfanyl-1-oxobutan-2-yl]carbamate	Investigative	137654305	C24H27ClFN5O3S	520	CC(C)(C)OC(=O)N[C@H](CCSC)C(=O)NC1=CC2=C(C=C1)N=CN=C2NC3=CC(=C(C=C3)F)Cl	IC50 ~ 100000 nM	Poor binder
T46781	Aurora kinase B	BSY5C8	Tert-butyl N-[(2R,3S)-3-methyl-1-oxo-1-[[4-[3-(trifluoromethyl)anilino]quinazolin-6-yl]amino]pentan-2-yl]carbamate	Investigative	137658608	C26H30F3N5O3	517.5	CC[C@H](C)[C@H](C(=O)NC1=CC2=C(C=C1)N=CN=C2NC3=CC=CC(=C3)C(F)(F)F)NC(=O)OC(C)(C)C	IC50 ~ 100000 nM	Poor binder
T46781	Aurora kinase B	BTL15P	2-(1,3-Dimethyl-1H-pyrazole-4-yl)-6-chloro-7-[4-(phenylcarbamoyl)phenoxy]-3H-imidazo[4,5-b]pyridine	Investigative	72734886	C24H19ClN6O2	458.9	CC1=NN(C=C1C2=NC3=NC=C(C(=C3N2)OC4=CC=C(C=C4)C(=O)NC5=CC=CC=C5)Cl)C	IC50 = 76840 nM	Poor binder
T46781	Aurora kinase B	BUDP24	Tert-butyl N-[(2R)-1-[[4-(3-bromoanilino)quinazolin-6-yl]amino]-3-methyl-1-oxobutan-2-yl]carbamate	Investigative	137638900	C24H28BrN5O3	514.4	CC(C)[C@H](C(=O)NC1=CC2=C(C=C1)N=CN=C2NC3=CC(=CC=C3)Br)NC(=O)OC(C)(C)C	IC50 ~ 100000 nM	Poor binder
T46781	Aurora kinase B	BV18AR	(3Z)-7-Iodo-3-(3-oxo-1H-indol-2-ylidene)-1H-indol-2-one	Investigative	135423784	C16H9IN2O2	388.16	C1=CC=C2C(=C1)C(=O)C(=N2)C3=C(NC4=C3C=CC=C4I)O	IC50 ~ 100000 nM	Poor binder
T46781	Aurora kinase B	BV26FR	N-(2-Chlorophenyl)-2-(1-methylpyrazol-4-yl)-1H-pyrrolo[3,2-c]pyridin-6-amine	Investigative	68291448	C17H14ClN5	323.8	CN1C=C(C=N1)C2=CC3=CN=C(C=C3N2)NC4=CC=CC=C4Cl	IC50 ~ 100000 nM	Poor binder
T46781	Aurora kinase B	BV51JC	7-Chloroindirubin-3-methoxime	Investigative	136104463	C17H12ClN3O2	325.7	CO/N=C\\1/C2=CC=CC=C2N=C1C3=C(NC4=C3C=CC=C4Cl)O	IC50 ~ 100000 nM	Poor binder
T46781	Aurora kinase B	BV94MX	Methyl 3-[1-[4-hydroxy-3-[[3-(trifluoromethyl)phenyl]carbamoyl]phenyl]triazol-4-yl]benzoate	Investigative	118710482	C24H17F3N4O4	482.4	COC(=O)C1=CC=CC(=C1)C2=CN(N=N2)C3=CC(=C(C=C3)O)C(=O)NC4=CC=CC(=C4)C(F)(F)F	IC50 = 63200 nM	Poor binder
T46781	Aurora kinase B	BV9WQ8	N-(4-Ethoxyphenyl)-4-(1-methylbenzimidazol-2-yl)pyrimidin-2-amine	Investigative	60166136	C20H19N5O	345.4	CCOC1=CC=C(C=C1)NC2=NC=CC(=N2)C3=NC4=CC=CC=C4N3C	IC50 ~ 100000 nM	Poor binder
T46781	Aurora kinase B	BVMW32	N-(4-Methoxyphenyl)-4-(1-methylbenzimidazol-2-yl)pyrimidin-2-amine	Investigative	60166137	C19H17N5O	331.4	CN1C2=CC=CC=C2N=C1C3=NC(=NC=C3)NC4=CC=C(C=C4)OC	IC50 = 62000 nM	Poor binder
T46781	Aurora kinase B	BVW47M	1,3-Dimethyl-7-(1-methylbenzimidazol-2-yl)pyrido[2,3-d]pyrimidine-2,4-dione	Investigative	60165992	C17H15N5O2	321.33	CN1C2=CC=CC=C2N=C1C3=NC4=C(C=C3)C(=O)N(C(=O)N4C)C	IC50 ~ 100000 nM	Poor binder
T46781	Aurora kinase B	BW0JC8	Chembl4290414	Investigative	145988464	C20H16ClN5O2	393.8	CC1=CC(=NN1)NC2=NC(=NC3=C2C=CC(=C3)Cl)C(=O)C4=CC=C(C=C4)OC	IC50 ~ 100000 nM	Poor binder
T46781	Aurora kinase B	BWTX40	4-[(5-Methyl-1h-Pyrazol-3-Yl)amino]-2-Phenylphthalazin-1(2h)-One	Investigative	11652621	C18H15N5O	317.3	CC1=CC(=NN1)NC2=NN(C(=O)C3=CC=CC=C32)C4=CC=CC=C4	IC50 ~ 100000 nM	Poor binder
T46781	Aurora kinase B	BWZ04D	Tert-butyl N-[(2R)-1-oxo-1-[[4-[3-(trifluoromethyl)anilino]quinazolin-6-yl]amino]propan-2-yl]carbamate	Investigative	137658479	C23H24F3N5O3	475.5	C[C@H](C(=O)NC1=CC2=C(C=C1)N=CN=C2NC3=CC=CC(=C3)C(F)(F)F)NC(=O)OC(C)(C)C	IC50 ~ 100000 nM	Poor binder
T46781	Aurora kinase B	BX6G5I	N-(2-Methoxyphenyl)-2-(1,3-Oxazol-5-Yl)-1h-Pyrrolo[3,2-C]pyridin-6-Amine	Investigative	66548458	C17H14N4O2	306.32	COC1=CC=CC=C1NC2=NC=C3C=C(NC3=C2)C4=CN=CO4	IC50 ~ 100000 nM	Poor binder
T46781	Aurora kinase B	BY53OT	3-Chloro-N,N-dimethyl-4-[[2-(1-methylpyrazol-4-yl)-1H-pyrrolo[3,2-c]pyridin-6-yl]amino]benzamide	Investigative	68290838	C20H19ClN6O	394.9	CN1C=C(C=N1)C2=CC3=CN=C(C=C3N2)NC4=C(C=C(C=C4)C(=O)N(C)C)Cl	IC50 ~ 100000 nM	Poor binder
T46781	Aurora kinase B	BY7MP5	5-(1H-Indol-3-yl)-3-(3,4,5-trimethoxyphenyl)-1H-pyrazin-2-one	Investigative	118723185	C21H19N3O4	377.4	COC1=CC(=CC(=C1OC)OC)C2=NC(=CNC2=O)C3=CNC4=CC=CC=C43	IC50 ~ 100000 nM	Poor binder
T46781	Aurora kinase B	BYB0C2	24-Exomethylenecalicoferol E	Investigative	10047202	C28H42O2	410.6	CC1=C(C=C(C=C1)O)CC[C@H]2[C@@H]3CC[C@@H]([C@]3(CCC2=O)C)[C@H](C)CCC(=C)C(C)C	IC50 ~ 100000 nM	Poor binder
T46781	Aurora kinase B	BYWO86	Tert-butyl N-[(2R)-4-methyl-1-oxo-1-[[4-[3-(trifluoromethyl)anilino]quinazolin-6-yl]amino]pentan-2-yl]carbamate	Investigative	137637664	C26H30F3N5O3	517.5	CC(C)C[C@H](C(=O)NC1=CC2=C(C=C1)N=CN=C2NC3=CC=CC(=C3)C(F)(F)F)NC(=O)OC(C)(C)C	IC50 ~ 100000 nM	Poor binder