TTD_Target_ID	Target_Name	TTD_Drug_ID	Drug_Name	Drug_Highest_Status	Drug_PubchemID	Molecular_Formula	Molecular_Weight	Canonical_SMILES	Activity	Binder_Type
T52450	Matrix metalloproteinase-1	D0N6ZA	US9206139, 4	Patented	74221131	C20H24F3N3O3	411.4	CC(C)[C@H](CC1=CC=C(C=C1)C(F)(F)F)C(=O)NC[C@@]2(C(=O)NC(=O)N2)C3CC3	IC50 = 56800 nM	Poor binder
T52450	Matrix metalloproteinase-1	B07UOM	N-Hydroxy-N-[2-[4-(4-trifluoromethoxy-phenoxy)-benzenesulfonyl]-1-(2,2,5-trimethyl-[1,3]dioxolan-4-yl)-ethyl]-formamide	Investigative	44314366	C22H24F3NO8S	519.5	C[C@H]1C(OC(O1)(C)C)[C@@H](CS(=O)(=O)C2=CC=C(C=C2)OC3=CC=C(C=C3)OC(F)(F)F)N(C=O)O	IC50 ~ 50000 nM	Poor binder
T52450	Matrix metalloproteinase-1	B0CFK6	Thioacetic acid S-[(4S,5S)-2-(4-chloro-phenyl)-5-vinyl-4,5-dihydro-oxazol-4-yl] ester	Investigative	44394754	C13H12ClNO2S	281.76	CC(=O)S[C@H]1[C@@H](OC(=N1)C2=CC=C(C=C2)Cl)C=C	Ki ~ 100000 nM	Poor binder
T52450	Matrix metalloproteinase-1	B0DQ4U	(2S)-2-[[(2S)-2-[[(2R)-2-Aminopropanoyl]amino]-3-phenylpropanoyl]amino]-4-methyl-N-phenylpentanamide	Investigative	44356805	C24H32N4O3	424.5	C[C@H](C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CC(C)C)C(=O)NC2=CC=CC=C2)N	IC50 = 52100 nM	Poor binder
T52450	Matrix metalloproteinase-1	B0G6CN	(2R)-2-[(4-But-2-ynoxyphenyl)sulfonylamino]-3-[1-[(4-methoxyphenyl)methyl]indol-3-yl]propanoic acid	Investigative	11599024	C29H28N2O6S	532.6	CC#CCOC1=CC=C(C=C1)S(=O)(=O)N[C@H](CC2=CN(C3=CC=CC=C32)CC4=CC=C(C=C4)OC)C(=O)O	IC50 ~ 50000 nM	Poor binder
T52450	Matrix metalloproteinase-1	B0H7LV	2-Benzo[1,3]dioxol-5-ylmethyl-N*4*-hydroxy-N*1*-(2-hydroxy-indan-1-yl)-succinamide	Investigative	15524390	C21H22N2O6	398.4	C1[C@H]([C@H](C2=CC=CC=C21)NC(=O)[C@H](CC3=CC4=C(C=C3)OCO4)CC(=O)NO)O	Ki = 50000 nM	Poor binder
T52450	Matrix metalloproteinase-1	B0J4RS	(R)-2-(N-Isopropoxybiphenyl-4-ylsulfonamido)-3-methylbutanoic acid	Investigative	45482676	C20H25NO5S	391.5	CC(C)[C@H](C(=O)O)N(OC(C)C)S(=O)(=O)C1=CC=C(C=C1)C2=CC=CC=C2	IC50 ~ 100000 nM	Poor binder
T52450	Matrix metalloproteinase-1	B0S6NQ	N-(4-Amino-2-methylquinolin-6-yl)-3-isoquinolin-4-ylbenzamide	Investigative	73056179	C26H20N4O	404.5	CC1=CC(=C2C=C(C=CC2=N1)NC(=O)C3=CC=CC(=C3)C4=CN=CC5=CC=CC=C54)N	IC50 = 50000 nM	Poor binder
T52450	Matrix metalloproteinase-1	B0V4OK	Naphthalen-1-yl 6-oxo-1,6-dihydropyridine-2-carboxylate	Investigative	44445229	C16H11NO3	265.26	C1=CC=C2C(=C1)C=CC=C2OC(=O)C3=CC=CC(=O)N3	IC50 = 115000 nM	Poor binder
T52450	Matrix metalloproteinase-1	B0W1VQ	4-[4-(Thiirane-2-ylmethylsulfonyl)phenoxy]phenol	Investigative	15941550	C15H14O4S2	322.4	C1C(S1)CS(=O)(=O)C2=CC=C(C=C2)OC3=CC=C(C=C3)O	Ki = 128000 nM	Poor binder
T52450	Matrix metalloproteinase-1	B12CRJ	N-[(2S)-1-(Dimethylamino)-3,3-dimethyl-1-oxobutan-2-yl]-2-[[formyl(hydroxy)amino]methyl]hexanamide	Investigative	22096205	C16H31N3O4	329.43	CCCCC(CN(C=O)O)C(=O)N[C@H](C(=O)N(C)C)C(C)(C)C	IC50 ~ 100000 nM	Poor binder
T52450	Matrix metalloproteinase-1	B19UTG	N-(4-Amino-2-methylquinolin-6-yl)-4-isoquinolin-4-ylbenzamide	Investigative	73055903	C26H20N4O	404.5	CC1=CC(=C2C=C(C=CC2=N1)NC(=O)C3=CC=C(C=C3)C4=CN=CC5=CC=CC=C54)N	IC50 ~ 100000 nM	Poor binder
T52450	Matrix metalloproteinase-1	B1DGY0	(R)-3-((S)-1-((S)-2-Methoxy-1-phenylethylamino)-3,3-dimethyl-1-oxobutan-2-ylcarbamoyl)-6-(2-methylbiphenyl-4-YL)hexanoic acid	Investigative	9808181	C35H44N2O5	572.7	CC1=C(C=CC(=C1)CCC[C@H](CC(=O)O)C(=O)N[C@H](C(=O)N[C@H](COC)C2=CC=CC=C2)C(C)(C)C)C3=CC=CC=C3	IC50 ~ 100000 nM	Poor binder
T52450	Matrix metalloproteinase-1	B1JQZ0	(2S)-2-[(7,7-Dimethyl-2-oxo-1-bicyclo[2.2.1]heptanyl)methylsulfonylamino]-N-[(2S)-1-oxo-1-[(2-sulfanylidene-3H-1,3,4-thiadiazol-5-yl)amino]propan-2-yl]-3-phenylpropanamide	Investigative	90663080	C24H31N5O5S3	565.7	C[C@@H](C(=O)NC1=NNC(=S)S1)NC(=O)[C@H](CC2=CC=CC=C2)NS(=O)(=O)CC34CCC(C3(C)C)CC4=O	Ki = 69000 nM	Poor binder
T52450	Matrix metalloproteinase-1	B1M5KY	N-Hydroxy-2-[4-(4-bromobenzyloxy)phenylsulfonylamino]acetamide	Investigative	72713638	C15H15BrN2O5S	415.3	C1=CC(=CC=C1COC2=CC=C(C=C2)S(=O)(=O)NCC(=O)NO)Br	IC50 = 120000 nM	Poor binder
T52450	Matrix metalloproteinase-1	B1OFL3	Hexyl 6-mercaptopicolinate	Investigative	44445270	C12H17NO2S	239.34	CCCCCCOC(=O)C1=CC=CC(=S)N1	IC50 = 115000 nM	Poor binder
T52450	Matrix metalloproteinase-1	B1RLZ5	4-[2-[Formyl(hydroxy)amino]-3-[4-[4-(trifluoromethoxy)phenoxy]phenyl]sulfonylpropyl]benzoic acid	Investigative	90667651	C24H20F3NO8S	539.5	C1=CC(=CC=C1CC(CS(=O)(=O)C2=CC=C(C=C2)OC3=CC=C(C=C3)OC(F)(F)F)N(C=O)O)C(=O)O	IC50 ~ 50000 nM	Poor binder
T52450	Matrix metalloproteinase-1	B1YM9Q	(Methylamino)carbonylphosphonic acid	Investigative	11457732	C2H6NO4P	139.05	CNC(=O)P(=O)(O)O	IC50 ~ 100000 nM	Poor binder
T52450	Matrix metalloproteinase-1	B1ZH3O	1-[2-[4-(4-Cyanophenyl)phenoxy]ethyl]-1-hydroxyurea	Investigative	44286406	C16H15N3O3	297.31	C1=CC(=CC=C1C#N)C2=CC=C(C=C2)OCCN(C(=O)N)O	IC50 ~ 50000 nM	Poor binder
T52450	Matrix metalloproteinase-1	B25XRZ	Cyclohexanamine;3-methylbutylcarbamoylphosphonic acid	Investigative	9817594	C12H27N2O4P	294.33	CC(C)CCNC(=O)P(=O)(O)O.C1CCC(CC1)N	IC50 ~ 100000 nM	Poor binder
T52450	Matrix metalloproteinase-1	B2AR5L	2-Phenoxyethyl 6-oxo-1,6-dihydropyridine-2-carboxylate	Investigative	44445211	C14H13NO4	259.26	C1=CC=C(C=C1)OCCOC(=O)C2=CC=CC(=O)N2	IC50 = 59000 nM	Poor binder
T52450	Matrix metalloproteinase-1	B2E8YD	4-{3-(Formyl-hydroxy-amino)-4-[4-(4-trifluoromethoxy-phenoxy)-benzenesulfonyl]-butyl}-benzoic acid methyl ester	Investigative	10303333	C26H24F3NO8S	567.5	COC(=O)C1=CC=C(C=C1)CCC(CS(=O)(=O)C2=CC=C(C=C2)OC3=CC=C(C=C3)OC(F)(F)F)N(C=O)O	IC50 ~ 50000 nM	Poor binder
T52450	Matrix metalloproteinase-1	B2EDN9	3-Methoxybenzyl 6-mercaptopicolinate	Investigative	44445251	C14H13NO3S	275.32	COC1=CC=CC(=C1)COC(=O)C2=CC=CC(=S)N2	IC50 = 86000 nM	Poor binder
T52450	Matrix metalloproteinase-1	B2EP1H	N-Hydroxy-2-[4-(3,5-difluorobenzyloxy)phenylsulfonylamino]acetamide	Investigative	72714081	C15H14F2N2O5S	372.3	C1=CC(=CC=C1OCC2=CC(=CC(=C2)F)F)S(=O)(=O)NCC(=O)NO	IC50 = 181000 nM	Poor binder
T52450	Matrix metalloproteinase-1	B2G4CK	(S)-2-(Acetyl-methyl-amino)-N-hydroxy-3-(4-phenoxy-benzenesulfonyl)-propionamide	Investigative	44325234	C18H20N2O6S	392.4	CC(=O)N(C)[C@H](CS(=O)(=O)C1=CC=C(C=C1)OC2=CC=CC=C2)C(=O)NO	IC50 = 90000 nM	Poor binder
T52450	Matrix metalloproteinase-1	B2H5RK	N-(4-Amino-2-methylquinolin-6-yl)-3-quinolin-5-ylbenzamide	Investigative	73056180	C26H20N4O	404.5	CC1=CC(=C2C=C(C=CC2=N1)NC(=O)C3=CC=CC(=C3)C4=C5C=CC=NC5=CC=C4)N	IC50 = 65000 nM	Poor binder
T52450	Matrix metalloproteinase-1	B2I7UA	1-Cinnamyl-4-(4,5-dihydrooxazol-2-yl)-1H-1,2,3-triazole	Investigative	44445277	C14H14N4O	254.29	C1COC(=N1)C2=CN(N=N2)C/C=C/C3=CC=CC=C3	IC50 ~ 150000 nM	Poor binder
T52450	Matrix metalloproteinase-1	B2J6IN	N-[(2S,4S)-1-[4-[2-[3-Chloro-5-(trifluoromethyl)pyridin-2-yl]ethyl]piperidin-1-yl]sulfonyl-4-(5-fluoropyrimidin-2-yl)-2-methylpentan-2-yl]-N-hydroxyformamide	Investigative	53320226	C24H30ClF4N5O4S	596	C[C@@H](C[C@@](C)(CS(=O)(=O)N1CCC(CC1)CCC2=C(C=C(C=N2)C(F)(F)F)Cl)N(C=O)O)C3=NC=C(C=N3)F	IC50 ~ 70000 nM	Poor binder
T52450	Matrix metalloproteinase-1	B2LIP5	3-Fluorobenzyl 6-mercaptopicolinate	Investigative	44445254	C13H10FNO2S	263.29	C1=CC(=CC(=C1)F)COC(=O)C2=CC=CC(=S)N2	IC50 = 119000 nM	Poor binder
T52450	Matrix metalloproteinase-1	B2PDW6	3-Phenoxybenzyl 6-mercaptopicolinate	Investigative	44445267	C19H15NO3S	337.4	C1=CC=C(C=C1)OC2=CC=CC(=C2)COC(=O)C3=CC=CC(=S)N3	IC50 = 78000 nM	Poor binder
T52450	Matrix metalloproteinase-1	B2XM4O	N-Hydroxy-2-[[4-[(3-phenylphenyl)methoxy]phenyl]sulfonylamino]acetamide	Investigative	72713867	C21H20N2O5S	412.5	C1=CC=C(C=C1)C2=CC=CC(=C2)COC3=CC=C(C=C3)S(=O)(=O)NCC(=O)NO	IC50 = 100000 nM	Poor binder
T52450	Matrix metalloproteinase-1	B30VXW	(E)-N-(4-Amino-2-methylquinolin-6-yl)-3-(2-methoxyphenyl)prop-2-enamide	Investigative	73056185	C20H19N3O2	333.4	CC1=CC(=C2C=C(C=CC2=N1)NC(=O)/C=C/C3=CC=CC=C3OC)N	IC50 ~ 100000 nM	Poor binder
T52450	Matrix metalloproteinase-1	B34QYF	N-[(2S)-3-(4-Methoxyphenyl)-1-(methylamino)-1-oxopropan-2-yl]-4-methyl-2-[(2-sulfanylidene-1H-pyridin-3-yl)methyl]pentanamide	Investigative	44333861	C23H31N3O3S	429.6	CC(C)CC(CC1=CC=CNC1=S)C(=O)N[C@@H](CC2=CC=C(C=C2)OC)C(=O)NC	IC50 ~ 100000 nM	Poor binder
T52450	Matrix metalloproteinase-1	B35HBC	(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2R)-2-Aminopropanoyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]hexanoyl]amino]-4-methylpentanoyl]amino]hexanamide	Investigative	44356767	C32H51N7O5	613.8	CCCC[C@@H](C(=O)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCC)NC(=O)[C@H](CC1=CNC2=CC=CC=C21)NC(=O)[C@@H](C)N	IC50 ~ 60000 nM	Poor binder
T52450	Matrix metalloproteinase-1	B35MBR	(1R,2S,5R)-2-[4-(4-Chlorophenyl)phenyl]sulfonyl-5-[(4-oxo-1,2,3-benzotriazin-3-yl)methyl]cyclopentane-1-carboxylic acid	Investigative	11135133	C26H22ClN3O5S	524	C1C[C@@H]([C@H]([C@@H]1CN2C(=O)C3=CC=CC=C3N=N2)C(=O)O)S(=O)(=O)C4=CC=C(C=C4)C5=CC=C(C=C5)Cl	IC50 ~ 100000 nM	Poor binder
T52450	Matrix metalloproteinase-1	B36MJV	5-[4-(4-Acetylphenyl)phenyl]-3-hydroxypentanoic acid	Investigative	11335940	C19H20O4	312.4	CC(=O)C1=CC=C(C=C1)C2=CC=C(C=C2)CCC(CC(=O)O)O	IC50 ~ 98000 nM	Poor binder
T52450	Matrix metalloproteinase-1	B37QZM	(S)-3-Cyclohexyl-N-methyl-2-[3-(5-thioxo-4,5-dihydro-[1,3,4]thiadiazol-2-yl)-ureido]-propionamide	Investigative	10854874	C13H21N5O2S2	343.5	CNC(=O)[C@H](CC1CCCCC1)NC(=O)NC2=NNC(=S)S2	Ki = 67000 nM	Poor binder
T52450	Matrix metalloproteinase-1	B38APD	(S)-3-Benzyloxy-N-methyl-2-[3-(5-thioxo-4,5-dihydro-[1,3,4]thiadiazol-2-yl)-ureido]-propionamide	Investigative	10595134	C14H17N5O3S2	367.5	CNC(=O)[C@H](COCC1=CC=CC=C1)NC(=O)NC2=NNC(=S)S2	Ki = 52000 nM	Poor binder
T52450	Matrix metalloproteinase-1	B3BU8I	N-[(2S,4S)-1-[4-[2-(2,5-Dimethylpyridin-4-yl)ethyl]piperidin-1-yl]sulfonyl-4-(5-fluoropyrimidin-2-yl)-2-methylpentan-2-yl]-N-hydroxyformamide	Investigative	53325499	C25H36FN5O4S	521.6	CC1=CC(=C(C=N1)C)CCC2CCN(CC2)S(=O)(=O)C[C@](C)(C[C@H](C)C3=NC=C(C=N3)F)N(C=O)O	IC50 ~ 100000 nM	Poor binder
T52450	Matrix metalloproteinase-1	B3C1QJ	(2S)-N-[(2S)-1-Amino-4-methyl-1-oxopentan-2-yl]-2-[[(2S)-2-[[(2R)-2-aminopropanoyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]hexanamide	Investigative	44356774	C26H40N6O4	500.6	CCCC[C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N)NC(=O)[C@H](CC1=CNC2=CC=CC=C21)NC(=O)[C@@H](C)N	IC50 ~ 60000 nM	Poor binder
T52450	Matrix metalloproteinase-1	B3C6LK	2-(2-Mercapto-benzyl)-4-methyl-pentanoic acid (2-oxo-azacyclotridec-3-yl)-amide	Investigative	44333652	C25H40N2O2S	432.7	CC(C)CC(CC1=CC=CC=C1S)C(=O)NC2CCCCCCCCCCNC2=O	IC50 ~ 100000 nM	Poor binder
T52450	Matrix metalloproteinase-1	B3DWU5	(3R)-6-Cyclohexyl-N-hydroxy-3-(3-{[(2-hydroxy-1,1-dimethylethyl)amino]methyl}-1,2,4-oxadiazol-5-yl)hexanamide	Investigative	10293283	C19H34N4O4	382.5	CC(C)(CO)NCC1=NOC(=N1)[C@H](CCCC2CCCCC2)CC(=O)NO	IC50 ~ 100000 nM	Poor binder
T52450	Matrix metalloproteinase-1	B3EAC2	N-[(2S,4S)-1-[4-[2-(2,5-Dimethylpyridin-3-yl)ethyl]piperidin-1-yl]sulfonyl-4-(5-fluoropyrimidin-2-yl)-2-methylpentan-2-yl]-N-hydroxyformamide	Investigative	53322877	C25H36FN5O4S	521.6	CC1=CC(=C(N=C1)C)CCC2CCN(CC2)S(=O)(=O)C[C@](C)(C[C@H](C)C3=NC=C(C=N3)F)N(C=O)O	IC50 = 55000 nM	Poor binder
T52450	Matrix metalloproteinase-1	B3F2EQ	3-((2-Phenethyl-2H-tetrazol-5-yl)methyl)pyridine	Investigative	44445279	C15H15N5	265.31	C1=CC=C(C=C1)CCN2N=C(N=N2)CC3=CN=CC=C3	IC50 ~ 150000 nM	Poor binder
T52450	Matrix metalloproteinase-1	B3FI7C	N-Hydroxybenzenesulfonamide	Investigative	69033	C6H7NO3S	173.19	C1=CC=C(C=C1)S(=O)(=O)NO	Ki = 79000 nM	Poor binder
T52450	Matrix metalloproteinase-1	B3H1MQ	3-[(S)-2-(4-Methoxy-phenyl)-1-methylcarbamoyl-ethylsulfamoyl]-5-methyl-hexanoic acid	Investigative	44315179	C18H28N2O6S	400.5	CC(C)CC(CC(=O)O)S(=O)(=O)N[C@@H](CC1=CC=C(C=C1)OC)C(=O)NC	Ki ~ 50000 nM	Poor binder
T52450	Matrix metalloproteinase-1	B3HJ0N	Hydroxysulfonamide 49	Investigative	23645539	C4H2F9NO3S	315.12	C(C(C(F)(F)S(=O)(=O)NO)(F)F)(C(F)(F)F)(F)F	Ki = 74000 nM	Poor binder
T52450	Matrix metalloproteinase-1	B3NPE5	2,5-Difluorobenzyl 6-mercaptopicolinate	Investigative	44445257	C13H9F2NO2S	281.28	C1=CC(=S)NC(=C1)C(=O)OCC2=C(C=CC(=C2)F)F	IC50 = 114000 nM	Poor binder
T52450	Matrix metalloproteinase-1	B3S5OF	4-Chloro-N-hydroxybenzene-1-sulfonamide	Investigative	352863	C6H6ClNO3S	207.64	C1=CC(=CC=C1S(=O)(=O)NO)Cl	Ki = 71000 nM	Poor binder
T52450	Matrix metalloproteinase-1	B3TS1F	2-[3-(4-Biphenylyloxymethyl)-4-oxo-4-(hydroxyamino)butyl]-3-oxo-2,3-dihydro-1,2-benzisothiazole 1,1-dioxide	Investigative	9934240	C24H22N2O6S	466.5	C1=CC=C(C=C1)C2=CC=C(C=C2)OCC(CCN3C(=O)C4=CC=CC=C4S3(=O)=O)C(=O)NO	IC50 ~ 100000 nM	Poor binder
T52450	Matrix metalloproteinase-1	B41BIN	2,6-Difluorobenzyl 6-mercaptopicolinate	Investigative	44445256	C13H9F2NO2S	281.28	C1=CC(=C(C(=C1)F)COC(=O)C2=CC=CC(=S)N2)F	IC50 = 92000 nM	Poor binder
T52450	Matrix metalloproteinase-1	B46STP	4-Phenoxy-N-[(1R,2S)-2-sulfanylcyclopentyl]benzenesulfonamide	Investigative	71682766	C17H19NO3S2	349.5	C1C[C@H]([C@H](C1)S)NS(=O)(=O)C2=CC=C(C=C2)OC3=CC=CC=C3	Ki ~ 100000 nM	Poor binder
T52450	Matrix metalloproteinase-1	B49VDF	4-Methoxybenzyl 6-oxo-1,6-dihydropyridine-2-carboxylate	Investigative	44445210	C14H13NO4	259.26	COC1=CC=C(C=C1)COC(=O)C2=CC=CC(=O)N2	IC50 = 99000 nM	Poor binder
T52450	Matrix metalloproteinase-1	B4GX3O	(2S)-2-[[(2S)-2-[[(2R)-2-Aminopropanoyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]-4-methyl-N-[(1R)-1-phenylethyl]pentanamide	Investigative	44356775	C28H37N5O3	491.6	C[C@H](C1=CC=CC=C1)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC2=CNC3=CC=CC=C32)NC(=O)[C@@H](C)N	IC50 ~ 60000 nM	Poor binder
T52450	Matrix metalloproteinase-1	B4MKA1	N-(p-Fluorobenzenesulfonyl)hydroxylamine	Investigative	12635074	C6H6FNO3S	191.18	C1=CC(=CC=C1F)S(=O)(=O)NO	Ki = 74000 nM	Poor binder
T52450	Matrix metalloproteinase-1	B4R5IC	(2R,3Ar,7aR)-1-[2-[[4-[[4-chloro-3-[[2-(3,5-ditert-butyl-4-hydroxyphenyl)sulfanylacetyl]sulfamoyl]benzoyl]sulfamoyl]benzoyl]amino]-3-methylbutanoyl]-N-(1,1,1-trifluoro-4-methyl-2-oxopentan-3-yl)-2,3,3a,4,5,6,7,7a-octahydroindole-2-carboxamide	Investigative	44300181	C50H63ClF3N5O11S3	1098.7	CC(C)C(C(=O)C(F)(F)F)NC(=O)[C@H]1C[C@H]2CCCC[C@H]2N1C(=O)C(C(C)C)NC(=O)C3=CC=C(C=C3)S(=O)(=O)NC(=O)C4=CC(=C(C=C4)Cl)S(=O)(=O)NC(=O)CSC5=CC(=C(C(=C5)C(C)(C)C)O)C(C)(C)C	IC50 = 58000 nM	Poor binder
T52450	Matrix metalloproteinase-1	B57RUH	Prop-2-enyl 2-[(E)-3-(4-bromophenyl)prop-2-enoyl]oxy-3-(3,4-dimethoxyphenyl)propanoate	Investigative	71654195	C23H23BrO6	475.3	COC1=C(C=C(C=C1)CC(C(=O)OCC=C)OC(=O)/C=C/C2=CC=C(C=C2)Br)OC	IC50 ~ 100000 nM	Poor binder
T52450	Matrix metalloproteinase-1	B5AZC3	N-Hydroxy-N-{3-morpholin-4-yl-1-[4-(4-trifluoromethoxy-phenoxy)-benzenesulfonylmethyl]-propyl}-formamide	Investigative	10301524	C22H25F3N2O7S	518.5	C1COCCN1CCC(CS(=O)(=O)C2=CC=C(C=C2)OC3=CC=C(C=C3)OC(F)(F)F)N(C=O)O	IC50 ~ 50000 nM	Poor binder
T52450	Matrix metalloproteinase-1	B5B8FZ	Naphthalen-1-yl 6-mercaptopicolinate	Investigative	44445263	C16H11NO2S	281.3	C1=CC=C2C(=C1)C=CC=C2OC(=O)C3=CC=CC(=S)N3	IC50 ~ 150000 nM	Poor binder
T52450	Matrix metalloproteinase-1	B5CZ4E	3-(3,4-Dimethoxyphenyl)-2-[(E)-3-(3,4-dimethoxyphenyl)prop-2-enoyl]oxypropanoic acid	Investigative	53375373	C22H24O8	416.4	COC1=C(C=C(C=C1)CC(C(=O)O)OC(=O)/C=C/C2=CC(=C(C=C2)OC)OC)OC	IC50 ~ 100000 nM	Poor binder
T52450	Matrix metalloproteinase-1	B5D0HM	Prop-2-enyl 3-(3,4-dimethoxyphenyl)-2-[(E)-3-(4-nitrophenyl)prop-2-enoyl]oxypropanoate	Investigative	71654355	C23H23NO8	441.4	COC1=C(C=C(C=C1)CC(C(=O)OCC=C)OC(=O)/C=C/C2=CC=C(C=C2)[N+](=O)[O-])OC	IC50 ~ 100000 nM	Poor binder
T52450	Matrix metalloproteinase-1	B5DE2F	N-(1,1':4',1''-Terbenzene-4-ylmethyl)-3-hydroxy-4-oxo-6-methyl-4H-pyran-2-carboxamide	Investigative	54724681	C26H21NO4	411.4	CC1=CC(=O)C(=C(O1)C(=O)NCC2=CC=C(C=C2)C3=CC=C(C=C3)C4=CC=CC=C4)O	IC50 ~ 50000 nM	Poor binder
T52450	Matrix metalloproteinase-1	B5H7VZ	5-[4-[[3-Azido-5-(azidomethyl)benzoyl]amino]phenyl]-N-[7-(hydroxyamino)-7-oxoheptyl]-1,2-oxazole-3-carboxamide	Investigative	53361475	C25H26N10O5	546.5	C1=CC(=CC=C1C2=CC(=NO2)C(=O)NCCCCCCC(=O)NO)NC(=O)C3=CC(=CC(=C3)CN=[N+]=[N-])N=[N+]=[N-]	IC50 = 108000 nM	Poor binder
T52450	Matrix metalloproteinase-1	B5OC0L	CID 50943150	Investigative	50943150	C18H11N3S2	333.4	C1=CC=C2C(=C1)NC(=N2)/C(=C/C3=CC=C(S3)C4=CC=CS4)/C#N	IC50 ~ 100000 nM	Poor binder
T52450	Matrix metalloproteinase-1	B5Q8ZA	N-(2-Methyl-4-amino-6-quinolyl)-4-(6-quinolyl)benzamide	Investigative	73055013	C26H20N4O	404.5	CC1=CC(=C2C=C(C=CC2=N1)NC(=O)C3=CC=C(C=C3)C4=CC5=C(C=C4)N=CC=C5)N	IC50 ~ 100000 nM	Poor binder
T52450	Matrix metalloproteinase-1	B5S7LF	2-(Biphenyl-4-ylmethylsulfanyl)-5-(1,3-dioxo-1,3-dihydro-isoindol-2-ylmethyl)-cyclopentanecarboxylic acid	Investigative	11091928	C28H25NO4S	471.6	C1C[C@@H]([C@H]([C@@H]1CN2C(=O)C3=CC=CC=C3C2=O)C(=O)O)SCC4=CC=C(C=C4)C5=CC=CC=C5	IC50 ~ 100000 nM	Poor binder
T52450	Matrix metalloproteinase-1	B5ZP7Q	3-Acetoxy-5-(biphenyl-4-yl)pentanoic acid	Investigative	45482999	C19H20O4	312.4	CC(=O)OC(CCC1=CC=C(C=C1)C2=CC=CC=C2)CC(=O)O	IC50 ~ 98000 nM	Poor binder
T52450	Matrix metalloproteinase-1	B62FNU	(R)-2-(4''-((4-(4-Fluorobenzoyl)phenoxy)methyl)biphenyl-4-ylsulfonamido)-3-methylbutanoic acid	Investigative	11613810	C31H28FNO6S	561.6	CC(C)[C@H](C(=O)O)NS(=O)(=O)C1=CC=C(C=C1)C2=CC=C(C=C2)COC3=CC=C(C=C3)C(=O)C4=CC=C(C=C4)F	IC50 ~ 100000 nM	Poor binder
T52450	Matrix metalloproteinase-1	B6A7YN	(4S,5S)-2-(4-Chloro-phenyl)-5-vinyl-4,5-dihydro-oxazole-4-thiol	Investigative	44394744	C11H10ClNOS	239.72	C=C[C@H]1[C@@H](N=C(O1)C2=CC=C(C=C2)Cl)S	Ki ~ 100000 nM	Poor binder
T52450	Matrix metalloproteinase-1	B6BP5U	N-{1-(1,4-Dioxa-spiro[4.5]dec-8-yl)-2-[4-(4-trifluoromethoxy-phenoxy)-benzenesulfonyl]-ethyl}-N-hydroxy-formamide	Investigative	10907701	C24H26F3NO8S	545.5	C1CC2(CCC1C(CS(=O)(=O)C3=CC=C(C=C3)OC4=CC=C(C=C4)OC(F)(F)F)N(C=O)O)OCCO2	IC50 ~ 50000 nM	Poor binder
T52450	Matrix metalloproteinase-1	B6BTQ8	4-(4,5-Dihydrooxazol-2-yl)-1-phenethyl-1H-1,2,3-triazole	Investigative	44445275	C13H14N4O	242.28	C1COC(=N1)C2=CN(N=N2)CCC3=CC=CC=C3	IC50 ~ 150000 nM	Poor binder
T52450	Matrix metalloproteinase-1	B6BZ7Q	Benzyl 6-mercaptopicolinate	Investigative	44445244	C13H11NO2S	245.3	C1=CC=C(C=C1)COC(=O)C2=CC=CC(=S)N2	IC50 = 101000 nM	Poor binder
T52450	Matrix metalloproteinase-1	B6HBX9	(3R)-6-Cyclohexyl-N-hydroxy-3-(3-{[(phenylsulfonyl)amino]carbonyl}-1,2,4-oxadiazol-5-yl)hexanamide	Investigative	9890632	C21H28N4O6S	464.5	C1CCC(CC1)CCC[C@H](CC(=O)NO)C2=NC(=NO2)C(=O)NS(=O)(=O)C3=CC=CC=C3	IC50 ~ 100000 nM	Poor binder
T52450	Matrix metalloproteinase-1	B6HY7C	3-[1-(2-Carboxy-ethylcarbamoyl)-2-cyclohexyl-ethylcarbamoyl]-6-p-tolyl-hexanoic acid	Investigative	44314442	C26H38N2O6	474.6	CC1=CC=C(C=C1)CCC[C@H](CC(=O)O)C(=O)N[C@@H](CC2CCCCC2)C(=O)NCCC(=O)O	Ki = 100000 nM	Poor binder
T52450	Matrix metalloproteinase-1	B6J1EV	6-Mercapto-pyridine-2-carboxylic acid 4-methyl-benzyl ester	Investigative	44445248	C14H13NO2S	259.329	CC1=CC=C(C=C1)COC(=O)C2=CC=CC(=S)N2	IC50 ~ 150000 nM	Poor binder
T52450	Matrix metalloproteinase-1	B6O4DQ	(E)-N-Hydroxy-3-[4-(trifluoromethyl)phenyl]acrylamide	Investigative	53374826	C10H8F3NO2	231.17	C1=CC(=CC=C1/C=C/C(=O)NO)C(F)(F)F	IC50 ~ 100000 nM	Poor binder
T52450	Matrix metalloproteinase-1	B6RX0F	N-Hydroxy-N-{1-methoxymethyl-2-[4-(4-trifluoromethoxy-phenoxy)-benzenesulfonyl]-ethyl}-formamide	Investigative	11144824	C18H18F3NO7S	449.4	COCC(CS(=O)(=O)C1=CC=C(C=C1)OC2=CC=C(C=C2)OC(F)(F)F)N(C=O)O	IC50 ~ 50000 nM	Poor binder
T52450	Matrix metalloproteinase-1	B6W3RO	N-(4-Amino-2-methylquinolin-6-yl)-2-(4-phenylmethoxyphenoxy)acetamide	Investigative	73055016	C25H23N3O3	413.5	CC1=CC(=C2C=C(C=CC2=N1)NC(=O)COC3=CC=C(C=C3)OCC4=CC=CC=C4)N	IC50 ~ 100000 nM	Poor binder
T52450	Matrix metalloproteinase-1	B6XAU1	3-(3,4-Dimethoxyphenyl)-2-[(E)-3-phenylprop-2-enoyl]oxypropanoic acid	Investigative	71654517	C20H20O6	356.4	COC1=C(C=C(C=C1)CC(C(=O)O)OC(=O)/C=C/C2=CC=CC=C2)OC	IC50 = 53700 nM	Poor binder
T52450	Matrix metalloproteinase-1	B6Z5OF	3-[2-Cyclohexyl-1-(4-morpholin-4-yl-butylcarbamoyl)-ethylcarbamoyl]-6-p-tolyl-hexanoic acid	Investigative	44314824	C31H49N3O5	543.7	CC1=CC=C(C=C1)CCC[C@H](CC(=O)O)C(=O)N[C@@H](CC2CCCCC2)C(=O)NCCCCN3CCOCC3	Ki = 55000 nM	Poor binder
T52450	Matrix metalloproteinase-1	B7A4ML	5-(4-(Dibenzo[b,d]furan-3-yl)phenyl)-3-hydroxypentanoic acid	Investigative	45483022	C23H20O4	360.4	C1=CC=C2C(=C1)C3=C(O2)C=C(C=C3)C4=CC=C(C=C4)CCC(CC(=O)O)O	IC50 ~ 98000 nM	Poor binder
T52450	Matrix metalloproteinase-1	B7G2CJ	(4S,5S)-4-Phenylsulfanyl-2-p-tolyl-5-vinyl-4,5-dihydro-oxazole	Investigative	44394797	C18H17NOS	295.4	CC1=CC=C(C=C1)C2=N[C@H]([C@@H](O2)C=C)SC3=CC=CC=C3	Ki = 64000 nM	Poor binder
T52450	Matrix metalloproteinase-1	B7L5OB	4-Bromo-N-hydroxybenzenesulfonamide	Investigative	121255	C6H6BrNO3S	252.09	C1=CC(=CC=C1S(=O)(=O)NO)Br	Ki = 71000 nM	Poor binder
T52450	Matrix metalloproteinase-1	B7LQ0G	3-Hydroxy-6-methyl-4-oxo-4H-pyran-2-carboxylic acid (biphenyl-4-ylmethyl)-amide	Investigative	54687474	C20H17NO4	335.4	CC1=CC(=O)C(=C(O1)C(=O)NCC2=CC=C(C=C2)C3=CC=CC=C3)O	IC50 ~ 50000 nM	Poor binder
T52450	Matrix metalloproteinase-1	B7MFT8	(1R,2S,5R)-2-[2-[4-(4-Chlorophenyl)phenyl]ethylsulfonyl]-5-[(4-oxo-1,2,3-benzotriazin-3-yl)methyl]cyclopentane-1-carboxylic acid	Investigative	10875332	C28H26ClN3O5S	552	C1C[C@@H]([C@H]([C@@H]1CN2C(=O)C3=CC=CC=C3N=N2)C(=O)O)S(=O)(=O)CCC4=CC=C(C=C4)C5=CC=C(C=C5)Cl	IC50 ~ 100000 nM	Poor binder
T52450	Matrix metalloproteinase-1	B7R6HS	{2-[2-Cyclohexyl-1-(2-morpholin-4-yl-ethylcarbamoyl)-ethylcarbamoyl]-5-phenyl-pentyl}-phosphonic acid	Investigative	44314958	C27H44N3O6P	537.6	C1CCC(CC1)C[C@@H](C(=O)NCCN2CCOCC2)NC(=O)[C@H](CCCC3=CC=CC=C3)CP(=O)(O)O	Ki = 100000 nM	Poor binder
T52450	Matrix metalloproteinase-1	B7VS2E	3-Phenoxybenzyl 6-oxo-1,6-dihydropyridine-2-carboxylate	Investigative	44445234	C19H15NO4	321.3	C1=CC=C(C=C1)OC2=CC=CC(=C2)COC(=O)C3=CC=CC(=O)N3	IC50 = 68000 nM	Poor binder
T52450	Matrix metalloproteinase-1	B7W4AB	N-{[4-(But-2-yn-1-yloxy)phenyl]sulfonyl}-5-methyl-D-tryptophan	Investigative	42627769	C22H22N2O5S	426.5	CC#CCOC1=CC=C(C=C1)S(=O)(=O)N[C@H](CC2=CNC3=C2C=C(C=C3)C)C(=O)O	IC50 ~ 50000 nM	Poor binder
T52450	Matrix metalloproteinase-1	B7WNT8	4-Phenoxybutyl 6-oxo-1,6-dihydropyridine-2-carboxylate	Investigative	44445212	C16H17NO4	287.31	C1=CC=C(C=C1)OCCCCOC(=O)C2=CC=CC(=O)N2	IC50 = 67000 nM	Poor binder
T52450	Matrix metalloproteinase-1	B7Y9SC	(3S,4S)-3-(4-Phenoxybenzenesulfonamido)-4-mercaptopyrrolidine Hydrochloride	Investigative	71680707	C16H19ClN2O3S2	386.9	C1[C@@H]([C@H](CN1)S)NS(=O)(=O)C2=CC=C(C=C2)OC3=CC=CC=C3.Cl	Ki = 50000 nM	Poor binder
T52450	Matrix metalloproteinase-1	B7Z6GY	1-Cyclohexenyl-4-(4,5-dihydrooxazol-2-yl)-1H-1,2,3-triazole	Investigative	44445271	C11H14N4O	218.26	C1CCC(=CC1)N2C=C(N=N2)C3=NCCO3	IC50 ~ 150000 nM	Poor binder
T52450	Matrix metalloproteinase-1	B86FOU	2-(4-Oxo-4H-benzo[d][1,2,3]triazin-3-ylmethyl)-5-(4-thiazol-2-yl-phenylsulfanyl)-cyclopentanecarboxylic acid	Investigative	11026991	C23H20N4O3S2	464.6	C1C[C@@H]([C@H]([C@@H]1CN2C(=O)C3=CC=CC=C3N=N2)C(=O)O)SC4=CC=C(C=C4)C5=NC=CS5	IC50 ~ 100000 nM	Poor binder
T52450	Matrix metalloproteinase-1	B87DNV	(Hydroxyamino)(4-iodophenyl)sulfone	Investigative	5220706	C6H6INO3S	299.09	C1=CC(=CC=C1S(=O)(=O)NO)I	Ki = 66000 nM	Poor binder
T52450	Matrix metalloproteinase-1	B8CUO9	(2R,3R)-4-[2-(3-Chlorophenyl)pyrrolidin-1-yl]-2,3-dihydroxy-4-oxo-N-[(4-pyrazol-1-ylphenyl)methyl]butanamide	Investigative	46919610	C24H25ClN4O4	468.9	C1CC(N(C1)C(=O)[C@@H]([C@H](C(=O)NCC2=CC=C(C=C2)N3C=CC=N3)O)O)C4=CC(=CC=C4)Cl	Ki ~ 100000 nM	Poor binder
T52450	Matrix metalloproteinase-1	B8DC0N	Cyclooctylcarbamoylphosphonic Acid	Investigative	11817193	C9H18NO4P	235.22	C1CCCC(CCC1)NC(=O)P(=O)(O)O	IC50 ~ 100000 nM	Poor binder
T52450	Matrix metalloproteinase-1	B8DY7G	(R)-2-(4-Fluoro-3,5-dimethylphenylamino)-6-(4-fluorobenzylamino)-N-hydroxyhexanamide	Investigative	24871537	C21H27F2N3O2	391.5	CC1=CC(=CC(=C1F)C)N[C@H](CCCCNCC2=CC=C(C=C2)F)C(=O)NO	Ki ~ 50000 nM	Poor binder
T52450	Matrix metalloproteinase-1	B8H6ZF	6-Mercapto-pyridine-2-carboxylic acid biphenyl-4-ylmethyl ester	Investigative	44445265	C19H15NO2S	321.4	C1=CC=C(C=C1)C2=CC=C(C=C2)COC(=O)C3=CC=CC(=S)N3	IC50 = 119000 nM	Poor binder
T52450	Matrix metalloproteinase-1	B8KJ7I	(S)-2-(4-Fluoro-3,5-dimethylbenzyl)-6-(4-fluorobenzylamino)-N-hydroxyhexanamide	Investigative	24871655	C22H28F2N2O2	390.5	CC1=CC(=CC(=C1F)C)C[C@H](CCCCNCC2=CC=C(C=C2)F)C(=O)NO	Ki ~ 50000 nM	Poor binder
T52450	Matrix metalloproteinase-1	B8KZB0	(2S)-2-(Naphthalen-2-ylsulfonylamino)-N-[(2S)-1-oxo-1-[(2-sulfanylidene-3H-1,3,4-thiadiazol-5-yl)amino]propan-2-yl]-3-phenylpropanamide	Investigative	90663062	C24H23N5O4S3	541.7	C[C@@H](C(=O)NC1=NNC(=S)S1)NC(=O)[C@H](CC2=CC=CC=C2)NS(=O)(=O)C3=CC4=CC=CC=C4C=C3	Ki = 72000 nM	Poor binder
T52450	Matrix metalloproteinase-1	B8T3VS	(1S,2R,5S)-2-[4-(4-Chlorophenyl)phenyl]sulfanyl-5-[(4-oxo-1,2,3-benzotriazin-3-yl)methyl]cyclopentane-1-carboxylic acid	Investigative	9870269	C26H22ClN3O3S	492	C1C[C@H]([C@@H]([C@H]1CN2C(=O)C3=CC=CC=C3N=N2)C(=O)O)SC4=CC=C(C=C4)C5=CC=C(C=C5)Cl	IC50 = 67000 nM	Poor binder
T52450	Matrix metalloproteinase-1	B8U0SC	2-Chlorobenzyl 6-oxo-1,6-dihydropyridine-2-carboxylate	Investigative	44445222	C13H10ClNO3	263.67	C1=CC=C(C(=C1)COC(=O)C2=CC=CC(=O)N2)Cl	IC50 = 51000 nM	Poor binder
T52450	Matrix metalloproteinase-1	B8ZWO6	(2R,3R)-4-(2-(3-Chlorophenyl)pyrrolidin-1-yl)-2,3-dihydroxy-4-oxo-N-(2-(thiophen-2-yl)ethyl)butanamide	Investigative	11697504	C20H23ClN2O4S	422.9	C1CC(N(C1)C(=O)[C@@H]([C@H](C(=O)NCCC2=CC=CS2)O)O)C3=CC(=CC=C3)Cl	Ki ~ 50000 nM	Poor binder
T52450	Matrix metalloproteinase-1	B97DPI	(2R,3R)-4-[(2R)-2-(3-Chlorophenyl)pyrrolidin-1-yl]-2,3-dihydroxy-4-oxo-N-[(1R)-1-(4-pyrazol-1-ylphenyl)ethyl]butanamide	Investigative	46856241	C25H27ClN4O4	483	C[C@H](C1=CC=C(C=C1)N2C=CC=N2)NC(=O)[C@@H]([C@H](C(=O)N3CCC[C@@H]3C4=CC(=CC=C4)Cl)O)O	Ki ~ 100000 nM	Poor binder
T52450	Matrix metalloproteinase-1	B98CLB	N-(4-Amino-2-methylquinolin-6-yl)-3-quinolin-3-ylbenzamide	Investigative	73055907	C26H20N4O	404.5	CC1=CC(=C2C=C(C=CC2=N1)NC(=O)C3=CC=CC(=C3)C4=CC5=CC=CC=C5N=C4)N	IC50 ~ 100000 nM	Poor binder
T52450	Matrix metalloproteinase-1	B9GXZ2	(1R,2S,5R)-2-[2-[4-(4-Chlorophenyl)phenyl]ethylsulfanyl]-5-[(1,3-dioxoisoindol-2-yl)methyl]cyclopentane-1-carboxylic acid	Investigative	9892876	C29H26ClNO4S	520	C1C[C@@H]([C@H]([C@@H]1CN2C(=O)C3=CC=CC=C3C2=O)C(=O)O)SCCC4=CC=C(C=C4)C5=CC=C(C=C5)Cl	IC50 = 50000 nM	Poor binder
T52450	Matrix metalloproteinase-1	B9MBK4	3-{2-Cyclohexyl-1-[2-(4-sulfamoyl-phenyl)-ethylcarbamoyl]-ethylcarbamoyl}-6-(4-methoxy-phenyl)-hexanoic acid	Investigative	44314969	C31H43N3O7S	601.8	COC1=CC=C(C=C1)CCC[C@H](CC(=O)O)C(=O)N[C@@H](CC2CCCCC2)C(=O)NCCC3=CC=C(C=C3)S(=O)(=O)N	Ki = 100000 nM	Poor binder
T52450	Matrix metalloproteinase-1	B9Q2PE	(Dibutylamino)carbonylphosphonic acid	Investigative	11207122	C9H20NO4P	237.23	CCCCN(CCCC)C(=O)P(=O)(O)O	IC50 = 70000 nM	Poor binder
T52450	Matrix metalloproteinase-1	B9RCW3	Prop-2-enyl 3-(3,4-dimethoxyphenyl)-2-[(E)-3-(4-phenylmethoxyphenyl)prop-2-enoyl]oxypropanoate	Investigative	71654357	C30H30O7	502.6	COC1=C(C=C(C=C1)CC(C(=O)OCC=C)OC(=O)/C=C/C2=CC=C(C=C2)OCC3=CC=CC=C3)OC	IC50 ~ 100000 nM	Poor binder
T52450	Matrix metalloproteinase-1	B9SDM3	(2R)-2-[[4-[4-[(3-Methyl-1-benzofuran-2-yl)methoxy]phenyl]phenyl]sulfonylamino]-3-phenylpropanoic acid	Investigative	44406452	C31H27NO6S	541.6	CC1=C(OC2=CC=CC=C12)COC3=CC=C(C=C3)C4=CC=C(C=C4)S(=O)(=O)N[C@H](CC5=CC=CC=C5)C(=O)O	IC50 ~ 100000 nM	Poor binder
T52450	Matrix metalloproteinase-1	BA39YM	Phenethyl 6-mercaptopicolinate	Investigative	44445245	C14H13NO2S	259.329	C1=CC=C(C=C1)CCOC(=O)C2=CC=CC(=S)N2	IC50 = 120000 nM	Poor binder
T52450	Matrix metalloproteinase-1	BA8KI4	4-(4-(Thiiran-2-ylmethylsulfonyl)phenoxy)phenyl methanesulfonate	Investigative	15941677	C16H16O6S3	400.5	CS(=O)(=O)OC1=CC=C(C=C1)OC2=CC=C(C=C2)S(=O)(=O)CC3CS3	Ki = 140000 nM	Poor binder
T52450	Matrix metalloproteinase-1	BA8T1M	(2R)-2-(4-Fluoro-3,5-dimethylphenoxy)-6-[1-(4-fluorophenyl)propylamino]-N-hydroxyhexanamide	Investigative	70693710	C23H30F2N2O3	420.5	CCC(C1=CC=C(C=C1)F)NCCCC[C@H](C(=O)NO)OC2=CC(=C(C(=C2)C)F)C	Ki ~ 50000 nM	Poor binder
T52450	Matrix metalloproteinase-1	BA9D7M	(2R)-3-(1-Benzothiophen-3-yl)-2-[[5-[2-(4-butylphenyl)ethynyl]thiophen-2-yl]sulfonylamino]-N-hydroxypropanamide	Investigative	53329216	C27H26N2O4S3	538.7	CCCCC1=CC=C(C=C1)C#CC2=CC=C(S2)S(=O)(=O)N[C@H](CC3=CSC4=CC=CC=C43)C(=O)NO	IC50 = 56000 nM	Poor binder
T52450	Matrix metalloproteinase-1	BAFC17	Dipotassium;6-amino-2-[[2-[4-[3-(carboxylatomethylamino)-2-[[(2S,3S)-2-[[ethoxy(hydroxy)phosphoryl]amino]-3-methylpentanoyl]amino]-3-oxopropyl]phenoxy]acetyl]amino]hexanoate	Investigative	54584143	C27H42K2N5O11P	721.8	CC[C@H](C)[C@@H](C(=O)NC(CC1=CC=C(C=C1)OCC(=O)NC(CCCCN)C(=O)[O-])C(=O)NCC(=O)[O-])NP(=O)(O)OCC.[K+].[K+]	Ki = 50000 nM	Poor binder
T52450	Matrix metalloproteinase-1	BAJF80	Hydroxysulfonamide 50	Investigative	23645540	C8H2F17NO3S	515.15	C(C(C(C(C(F)(F)S(=O)(=O)NO)(F)F)(F)F)(F)F)(C(C(C(F)(F)F)(F)F)(F)F)(F)F	Ki = 70000 nM	Poor binder
T52450	Matrix metalloproteinase-1	BAN7Z4	(Cycloheptylamino)carbonylphosphonic acid	Investigative	11447356	C8H16NO4P	221.19	C1CCCC(CC1)NC(=O)P(=O)(O)O	IC50 ~ 100000 nM	Poor binder
T52450	Matrix metalloproteinase-1	BB68WX	N-(4-Amino-2-methylquinolin-6-yl)-3-quinolin-8-ylbenzamide	Investigative	73056181	C26H20N4O	404.5	CC1=CC(=C2C=C(C=CC2=N1)NC(=O)C3=CC=CC(=C3)C4=CC=CC5=C4N=CC=C5)N	IC50 ~ 100000 nM	Poor binder
T52450	Matrix metalloproteinase-1	BB6HM7	(4S)-5-Amino-5-oxo-4-[[(2S)-2-[3-(4-phenylphenyl)propanoylamino]butanoyl]amino]pentanoic acid	Investigative	71109175	C24H29N3O5	439.5	CC[C@@H](C(=O)N[C@@H](CCC(=O)O)C(=O)N)NC(=O)CCC1=CC=C(C=C1)C2=CC=CC=C2	Ki ~ 100000 nM	Poor binder
T52450	Matrix metalloproteinase-1	BB9JA3	But-2-ynyl 6-oxo-1,6-dihydropyridine-2-carboxylate	Investigative	44445202	C10H9NO3	191.18	CC#CCOC(=O)C1=CC=CC(=O)N1	IC50 = 50000 nM	Poor binder
T52450	Matrix metalloproteinase-1	BBF3R4	(Cyclopropylamino)carbonylphosphonic acid	Investigative	11252195	C4H8NO4P	165.08	C1CC1NC(=O)P(=O)(O)O	IC50 ~ 100000 nM	Poor binder
T52450	Matrix metalloproteinase-1	BBY86P	Benzenemethanesulfonamide, N-hydroxy-	Investigative	23645541	C7H9NO3S	187.22	C1=CC=C(C=C1)CS(=O)(=O)NO	Ki = 95000 nM	Poor binder
T52450	Matrix metalloproteinase-1	BC0GY1	N-Hydroxy-N-{1-(1-methyl-1H-indol-2-yl)-2-[4-(4-trifluoromethoxy-phenoxy)-benzenesulfonyl]-ethyl}-formamide	Investigative	11092701	C25H21F3N2O6S	534.5	CN1C2=CC=CC=C2C=C1C(CS(=O)(=O)C3=CC=C(C=C3)OC4=CC=C(C=C4)OC(F)(F)F)N(C=O)O	IC50 ~ 50000 nM	Poor binder
T52450	Matrix metalloproteinase-1	BC6DG0	(2S)-2-[(4-Fluoro-3,5-dimethylphenyl)methyl]-6-[1-(4-fluorophenyl)propylamino]-N-hydroxyhexanamide	Investigative	57345501	C24H32F2N2O2	418.5	CCC(C1=CC=C(C=C1)F)NCCCC[C@@H](CC2=CC(=C(C(=C2)C)F)C)C(=O)NO	Ki ~ 50000 nM	Poor binder
T52450	Matrix metalloproteinase-1	BC6KT9	(4S)-5-[[(2S)-1-Amino-3-carboxy-1-oxopropan-2-yl]amino]-5-oxo-4-[3-[4-(4-phenylthiophen-2-yl)phenyl]propanoylamino]pentanoic acid	Investigative	69922083	C28H29N3O7S	551.6	C1=CC=C(C=C1)C2=CSC(=C2)C3=CC=C(C=C3)CCC(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N	Ki ~ 100000 nM	Poor binder
T52450	Matrix metalloproteinase-1	BC74NY	2-[2-[(E)-(5-Oxo-2-sulfanylideneimidazolidin-4-ylidene)methyl]phenoxy]acetic acid	Investigative	703233	C12H10N2O4S	278.29	C1=CC=C(C(=C1)/C=C/2\\C(=O)NC(=S)N2)OCC(=O)O	IC50 = 114000 nM	Poor binder
T52450	Matrix metalloproteinase-1	BCIL03	(Hydroxysulfamoyl)dimethylamine	Investigative	12447203	C2H8N2O3S	140.16	CN(C)S(=O)(=O)NO	Ki ~ 100000 nM	Poor binder
T52450	Matrix metalloproteinase-1	BCLT94	N-[(2S,4S)-1-[4-[2-(4,6-Dimethylpyridin-3-yl)ethyl]piperidin-1-yl]sulfonyl-4-(5-fluoropyrimidin-2-yl)-2-methylpentan-2-yl]-N-hydroxyformamide	Investigative	53322879	C25H36FN5O4S	521.6	CC1=CC(=NC=C1CCC2CCN(CC2)S(=O)(=O)C[C@](C)(C[C@H](C)C3=NC=C(C=N3)F)N(C=O)O)C	IC50 ~ 100000 nM	Poor binder
T52450	Matrix metalloproteinase-1	BCUY95	(R)-2-(4''-((4-(Cyclohexanecarbonyl)phenoxy)methyl)biphenyl-4-ylsulfonamido)-3-methylbutanoic acid	Investigative	11526826	C31H35NO6S	549.7	CC(C)[C@H](C(=O)O)NS(=O)(=O)C1=CC=C(C=C1)C2=CC=C(C=C2)COC3=CC=C(C=C3)C(=O)C4CCCCC4	IC50 ~ 100000 nM	Poor binder
T52450	Matrix metalloproteinase-1	BCV7J5	(2S)-2-(Naphthalen-1-ylsulfonylamino)-N-[(2S)-1-oxo-1-[(2-sulfanylidene-3H-1,3,4-thiadiazol-5-yl)amino]propan-2-yl]-3-phenylpropanamide	Investigative	90663070	C24H23N5O4S3	541.7	C[C@@H](C(=O)NC1=NNC(=S)S1)NC(=O)[C@H](CC2=CC=CC=C2)NS(=O)(=O)C3=CC=CC4=CC=CC=C43	Ki = 80000 nM	Poor binder
T52450	Matrix metalloproteinase-1	BCZ94T	2-[(E)-3-(2,3-Dihydro-1-benzofuran-6-yl)prop-2-enoyl]oxy-3-(3,4-dimethoxyphenyl)propanoic acid	Investigative	71652363	C22H22O7	398.4	COC1=C(C=C(C=C1)CC(C(=O)O)OC(=O)/C=C/C2=CC3=C(CCO3)C=C2)OC	IC50 ~ 100000 nM	Poor binder
T52450	Matrix metalloproteinase-1	BD2V9Y	N-(Carboxymethyl)-N-(3-Phenylpropyl)glycyl-N-Methyl-L-Histidinamide	Investigative	54589400	C20H27N5O4	401.5	CNC(=O)[C@H](CC1=CN=CN1)NC(=O)CN(CCCC2=CC=CC=C2)CC(=O)O	IC50 ~ 100000 nM	Poor binder
T52450	Matrix metalloproteinase-1	BDJ7N6	4-(4,5-Dihydrooxazol-2-yl)-1-(3-phenylpropyl)-1H-1,2,3-triazole	Investigative	44445276	C14H16N4O	256.3	C1COC(=N1)C2=CN(N=N2)CCCC3=CC=CC=C3	IC50 ~ 150000 nM	Poor binder
T52450	Matrix metalloproteinase-1	BDO0J3	5-(4-(9H-Fluoren-2-yl)phenyl)-3-hydroxypentanoic acid	Investigative	45483016	C24H22O3	358.4	C1C2=CC=CC=C2C3=C1C=C(C=C3)C4=CC=C(C=C4)CCC(CC(=O)O)O	IC50 ~ 98000 nM	Poor binder
T52450	Matrix metalloproteinase-1	BE0RB9	(4S,5S)-4-Phenylsulfanyl-2-((E)-styryl)-5-vinyl-4,5-dihydro-oxazole	Investigative	44394594	C19H17NOS	307.4	C=C[C@H]1[C@@H](N=C(O1)/C=C/C2=CC=CC=C2)SC3=CC=CC=C3	Ki ~ 100000 nM	Poor binder
T52450	Matrix metalloproteinase-1	BE0ZB9	6-Mercapto-pyridine-2-carboxylic acid 3-methyl-benzyl ester	Investigative	44445247	C14H13NO2S	259.329	CC1=CC(=CC=C1)COC(=O)C2=CC=CC(=S)N2	IC50 ~ 150000 nM	Poor binder
T52450	Matrix metalloproteinase-1	BE46JH	2-[(4-But-2-ynoxyphenyl)sulfonylamino]-3-(5-methoxy-1H-indol-3-yl)propanoic Acid	Investigative	11510523	C22H22N2O6S	442.5	CC#CCOC1=CC=C(C=C1)S(=O)(=O)NC(CC2=CNC3=C2C=C(C=C3)OC)C(=O)O	IC50 ~ 50000 nM	Poor binder
T52450	Matrix metalloproteinase-1	BE53SW	N-Hydroxy-2-nitrobenzene-1-sulfonamide	Investigative	23645544	C6H6N2O5S	218.19	C1=CC=C(C(=C1)[N+](=O)[O-])S(=O)(=O)NO	Ki = 59000 nM	Poor binder
T52450	Matrix metalloproteinase-1	BE93AF	N-{1-(2,2-Dimethyl-[1,3]dioxolan-4-ylmethyl)-2-[4-(4-trifluoromethoxy-phenoxy)-benzenesulfonyl]-ethyl}-N-hydroxy-formamide	Investigative	44314349	C22H24F3NO8S	519.5	CC1(OCC(O1)C[C@@H](CS(=O)(=O)C2=CC=C(C=C2)OC3=CC=C(C=C3)OC(F)(F)F)N(C=O)O)C	IC50 ~ 50000 nM	Poor binder
T52450	Matrix metalloproteinase-1	BEUF79	(2R)-N-Hydroxy-4-methyl-2-[[methyl(phenyl)phosphoryl]amino]pentanamide	Investigative	10541018	C13H21N2O3P	284.29	CC(C)C[C@H](C(=O)NO)N[P@](=O)(C)C1=CC=CC=C1	IC50 ~ 100000 nM	Poor binder
T52450	Matrix metalloproteinase-1	BF0HQ4	Thiophen-2-yl 6-oxo-1,6-dihydropyridine-2-carboxylate	Investigative	44445235	C10H7NO3S	221.23	C1=CC(=O)NC(=C1)C(=O)OC2=CC=CS2	IC50 = 56000 nM	Poor binder
T52450	Matrix metalloproteinase-1	BF12NZ	4-Phenoxybenzyl 6-mercaptopicolinate	Investigative	44445268	C19H15NO3S	337.4	C1=CC=C(C=C1)OC2=CC=C(C=C2)COC(=O)C3=CC=CC(=S)N3	IC50 = 114000 nM	Poor binder
T52450	Matrix metalloproteinase-1	BF26XN	N-Hydroxy-N-[2-[4-(4-trifluoromethoxy-phenoxy)-benzenesulfonyl]-1-(4-trifluoromethyl-phenyl)-ethyl]-formamide	Investigative	10907740	C23H17F6NO6S	549.4	C1=CC(=CC=C1C(CS(=O)(=O)C2=CC=C(C=C2)OC3=CC=C(C=C3)OC(F)(F)F)N(C=O)O)C(F)(F)F	IC50 ~ 50000 nM	Poor binder
T52450	Matrix metalloproteinase-1	BF3U8K	(4S,5S)-2-Styryl-5-vinyl-4,5-dihydro-oxazole-4-thiol	Investigative	44394637	C13H13NOS	231.32	C=C[C@H]1[C@@H](N=C(O1)/C=C/C2=CC=CC=C2)S	Ki = 92000 nM	Poor binder
T52450	Matrix metalloproteinase-1	BF6WH4	N-Hydroxy-N-{1-(2-hydroxy-ethoxymethyl)-2-[4-(4-trifluoromethoxy-phenoxy)-benzenesulfonyl]-ethyl}-formamide	Investigative	10116618	C19H20F3NO8S	479.4	C1=CC(=CC=C1OC2=CC=C(C=C2)S(=O)(=O)CC(COCCO)N(C=O)O)OC(F)(F)F	IC50 ~ 50000 nM	Poor binder
T52450	Matrix metalloproteinase-1	BF78EK	N-Hydroxy-2-(N-isopropoxy-4-phenoxyphenylsulfonamido)-acetamide	Investigative	44219903	C17H20N2O6S	380.4	CC(C)ON(CC(=O)NO)S(=O)(=O)C1=CC=C(C=C1)OC2=CC=CC=C2	IC50 = 59000 nM	Poor binder
T52450	Matrix metalloproteinase-1	BFBK27	Naphthalen-2-yl 6-oxo-1,6-dihydropyridine-2-carboxylate	Investigative	44445230	C16H11NO3	265.26	C1=CC=C2C=C(C=CC2=C1)OC(=O)C3=CC=CC(=O)N3	IC50 = 75000 nM	Poor binder
T52450	Matrix metalloproteinase-1	BGA1L5	N-[2-[4-[4-(Trifluoromethoxy)phenoxy]phenylsulfonyl]-1-[(R)-tetrahydrofuran-2-yl]ethyl]-N-hydroxyformamide	Investigative	90667652	C20H20F3NO7S	475.4	C1C[C@@H](OC1)C(CS(=O)(=O)C2=CC=C(C=C2)OC3=CC=C(C=C3)OC(F)(F)F)N(C=O)O	IC50 ~ 50000 nM	Poor binder
T52450	Matrix metalloproteinase-1	BGH43F	3-[2-Cyclohexyl-1-(2-methoxycarbonyl-ethylcarbamoyl)-ethylcarbamoyl]-6-phenyl-hexanoic acid	Investigative	44315167	C26H38N2O6	474.6	COC(=O)CCNC(=O)[C@H](CC1CCCCC1)NC(=O)[C@H](CCCC2=CC=CC=C2)CC(=O)O	Ki = 57543.99 nM	Poor binder
T52450	Matrix metalloproteinase-1	BGN3P0	2-(2-(4-Methoxyphenylsulfonyl)phenyl)acetic Acid	Investigative	44479700	C15H14O5S	306.3	COC1=CC=C(C=C1)S(=O)(=O)C2=CC=CC=C2CC(=O)O	IC50 ~ 100000 nM	Poor binder
T52450	Matrix metalloproteinase-1	BGPR53	N-Hydroxy-4-methylbenzenesulfonamide	Investigative	10081163	C7H9NO3S	187.22	CC1=CC=C(C=C1)S(=O)(=O)NO	Ki = 65000 nM	Poor binder
T52450	Matrix metalloproteinase-1	BGU8W6	N-Hydroxy-N-{4-morpholin-4-yl-4-oxo-1-[4-(4-trifluoromethoxy-phenoxy)-benzenesulfonylmethyl]-butyl}-formamide	Investigative	10209301	C23H25F3N2O8S	546.5	C1COCCN1C(=O)CCC(CS(=O)(=O)C2=CC=C(C=C2)OC3=CC=C(C=C3)OC(F)(F)F)N(C=O)O	IC50 = 50000 nM	Poor binder
T52450	Matrix metalloproteinase-1	BGV36J	(4S,5S)-2-p-Tolyl-5-vinyl-4,5-dihydro-oxazole-4-thiol	Investigative	44394703	C12H13NOS	219.3	CC1=CC=C(C=C1)C2=N[C@H]([C@@H](O2)C=C)S	Ki ~ 100000 nM	Poor binder
T52450	Matrix metalloproteinase-1	BGXT10	2-Bromobenzyl 6-mercaptopicolinate	Investigative	44445262	C13H10BrNO2S	324.19	C1=CC=C(C(=C1)COC(=O)C2=CC=CC(=S)N2)Br	IC50 ~ 150000 nM	Poor binder
T52450	Matrix metalloproteinase-1	BGY1M0	1-[2-[4-(4-Cyanophenyl)phenoxy]ethyl]-3-hydroxyurea	Investigative	44286483	C16H15N3O3	297.31	C1=CC(=CC=C1C#N)C2=CC=C(C=C2)OCCNC(=O)NO	IC50 ~ 50000 nM	Poor binder
T52450	Matrix metalloproteinase-1	BH5Z8V	(S)-2-{4'-[(5-Iodo-4-methoxy-3-methyl-benzofuran-2-carbonyl)-amino]-biphenyl-4-sulfonylamino}-3-methyl-butyric acid	Investigative	11456566	C28H27IN2O7S	662.5	CC1=C(OC2=C1C(=C(C=C2)I)OC)C(=O)NC3=CC=C(C=C3)C4=CC=C(C=C4)S(=O)(=O)N[C@@H](C(C)C)C(=O)O	IC50 = 60000 nM	Poor binder
T52450	Matrix metalloproteinase-1	BH7FI5	Naphthalen-2-yl 6-mercaptopicolinate	Investigative	44445264	C16H11NO2S	281.3	C1=CC=C2C=C(C=CC2=C1)OC(=O)C3=CC=CC(=S)N3	IC50 = 99000 nM	Poor binder
T52450	Matrix metalloproteinase-1	BHK6A7	(2R)-2-Amino-N-[(2S)-1-[[(2S)-1-amino-1-oxo-3-phenylpropan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]-4-methylpentanamide	Investigative	44356667	C21H34N4O3	390.5	CC(C)C[C@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N)N	IC50 ~ 100000 nM	Poor binder
T52450	Matrix metalloproteinase-1	BHX3A1	N-({4'-[(4-Isobutyrylphenoxy)methyl]biphenyl-4-Yl}sulfonyl)-D-Valine	Investigative	11691964	C28H31NO6S	509.6	CC(C)[C@H](C(=O)O)NS(=O)(=O)C1=CC=C(C=C1)C2=CC=C(C=C2)COC3=CC=C(C=C3)C(=O)C(C)C	IC50 ~ 100000 nM	Poor binder
T52450	Matrix metalloproteinase-1	BI3S2D	2-(3''-Bromo-biphenyl-4-sulfonylamino)-3-methyl-butyric acid	Investigative	10692994	C17H18BrNO4S	412.3	CC(C)[C@@H](C(=O)O)NS(=O)(=O)C1=CC=C(C=C1)C2=CC(=CC=C2)Br	IC50 = 100000 nM	Poor binder
T52450	Matrix metalloproteinase-1	BI73TH	4-Fluorobenzyl 6-mercaptopicolinate	Investigative	44445255	C13H10FNO2S	263.29	C1=CC(=S)NC(=C1)C(=O)OCC2=CC=C(C=C2)F	IC50 = 120000 nM	Poor binder
T52450	Matrix metalloproteinase-1	BI7Y5L	1,1,1-Trifluoro-N-hydroxymethanesulfonamide	Investigative	23644662	CH2F3NO3S	165.09	C(F)(F)(F)S(=O)(=O)NO	Ki ~ 100000 nM	Poor binder
T52450	Matrix metalloproteinase-1	BIDO53	Thiophen-3-yl 6-mercaptopicolinate	Investigative	44445269	C10H7NO2S2	237.3	C1=CC(=S)NC(=C1)C(=O)OC2=CSC=C2	IC50 = 108000 nM	Poor binder
T52450	Matrix metalloproteinase-1	BIV63S	5-(4''-(Benzyloxy)biphenyl-4-yl)-3-hydroxypentanoic acid	Investigative	45483036	C24H24O4	376.4	C1=CC=C(C=C1)COC2=CC=C(C=C2)C3=CC=C(C=C3)CCC(CC(=O)O)O	IC50 ~ 98000 nM	Poor binder
T52450	Matrix metalloproteinase-1	BJ06HE	(2R)-3-Methyl-2-[[4-[4-[(5-oxo-7,8-dihydro-6H-naphthalen-2-yl)oxymethyl]phenyl]phenyl]sulfonylamino]butanoic acid	Investigative	11569716	C28H29NO6S	507.6	CC(C)[C@H](C(=O)O)NS(=O)(=O)C1=CC=C(C=C1)C2=CC=C(C=C2)COC3=CC4=C(C=C3)C(=O)CCC4	IC50 ~ 100000 nM	Poor binder
T52450	Matrix metalloproteinase-1	BJ0K8P	(2S)-2-[[4-(4-Bromophenyl)phenyl]sulfonylamino]-3-phenylpropanoic acid	Investigative	10551910	C21H18BrNO4S	460.3	C1=CC=C(C=C1)C[C@@H](C(=O)O)NS(=O)(=O)C2=CC=C(C=C2)C3=CC=C(C=C3)Br	IC50 = 56000 nM	Poor binder
T52450	Matrix metalloproteinase-1	BJ3L1G	N-(4-Amino-2-methylquinolin-6-yl)-4-quinolin-3-ylbenzamide	Investigative	73055902	C26H20N4O	404.5	CC1=CC(=C2C=C(C=CC2=N1)NC(=O)C3=CC=C(C=C3)C4=CC5=CC=CC=C5N=C4)N	IC50 = 78000 nM	Poor binder
T52450	Matrix metalloproteinase-1	BJ6W4D	4-(4-Methoxyphenyl)-N-(2-morpholin-4-ylethyl)thiophene-2-carboxamide	Investigative	3649035	C18H22N2O3S	346.4	COC1=CC=C(C=C1)C2=CSC(=C2)C(=O)NCCN3CCOCC3	IC50 ~ 101000 nM	Poor binder
T52450	Matrix metalloproteinase-1	BJF61I	N-(2-Methyl-4-amino-6-quinolyl)-3-(2-methoxyphenyl)propionamide	Investigative	73055018	C20H21N3O2	335.4	CC1=CC(=C2C=C(C=CC2=N1)NC(=O)CCC3=CC=CC=C3OC)N	IC50 ~ 100000 nM	Poor binder
T52450	Matrix metalloproteinase-1	BJHU70	(1R,2R,5S)-2-[(2,4-Dioxopyrido[1,2-a][1,3,5]triazin-3-yl)methyl]-5-[4-(4-methylsulfanylphenyl)phenyl]sulfanylcyclopentane-1-carboxylic acid	Investigative	11092551	C27H25N3O4S2	519.6	CSC1=CC=C(C=C1)C2=CC=C(C=C2)S[C@H]3CC[C@H]([C@@H]3C(=O)O)CN4C(=O)N=C5C=CC=CN5C4=O	IC50 = 63000 nM	Poor binder
T52450	Matrix metalloproteinase-1	BJM5H0	(2E)-2-(1H-Benzimidazol-2-yl)-3-(3-iodo-4-methoxyphenyl)prop-2-enenitrile	Investigative	5941957	C17H12IN3O	401.2	COC1=C(C=C(C=C1)/C=C(\\C#N)/C2=NC3=CC=CC=C3N2)I	IC50 ~ 100000 nM	Poor binder
T52450	Matrix metalloproteinase-1	BJR8V5	N-(4-Amino-2-methylquinolin-6-yl)-3-[2-(trifluoromethyl)phenyl]propanamide	Investigative	73056183	C20H18F3N3O	373.4	CC1=CC(=C2C=C(C=CC2=N1)NC(=O)CCC3=CC=CC=C3C(F)(F)F)N	IC50 ~ 100000 nM	Poor binder
T52450	Matrix metalloproteinase-1	BJW19F	3-((2-Benzyl-2H-tetrazol-5-yl)methyl)pyridine	Investigative	44445278	C14H13N5	251.29	C1=CC=C(C=C1)CN2N=C(N=N2)CC3=CN=CC=C3	IC50 ~ 150000 nM	Poor binder
T52450	Matrix metalloproteinase-1	BK2NS9	Pentyl 6-oxo-1,6-dihydropyridine-2-carboxylate	Investigative	44445240	C11H15NO3	209.24	CCCCCOC(=O)C1=CC=CC(=O)N1	IC50 = 50000 nM	Poor binder
T52450	Matrix metalloproteinase-1	BK2OM0	(R)-2-Dodecyl-N4-hydroxy-N1-((S)-1-(methylamino)-1-oxo-3-phenylpropan-2-yl)succinamide	Investigative	44302359	C26H43N3O4	461.6	CCCCCCCCCCCC[C@H](CC(=O)NO)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)NC	IC50 = 50000 nM	Poor binder
T52450	Matrix metalloproteinase-1	BK2Y7S	(1R,2S,5R)-2-[2-[4-(4-Chlorophenyl)phenyl]ethylsulfanyl]-5-[(4-oxo-1,2,3-benzotriazin-3-yl)methyl]cyclopentane-1-carboxylic acid	Investigative	10929404	C28H26ClN3O3S	520	C1C[C@@H]([C@H]([C@@H]1CN2C(=O)C3=CC=CC=C3N=N2)C(=O)O)SCCC4=CC=C(C=C4)C5=CC=C(C=C5)Cl	IC50 ~ 70000 nM	Poor binder
T52450	Matrix metalloproteinase-1	BK3V9T	N-(4-Amino-2-methylquinolin-6-yl)-3-(2-methoxypyridin-3-yl)propanamide	Investigative	73056773	C19H20N4O2	336.4	CC1=CC(=C2C=C(C=CC2=N1)NC(=O)CCC3=C(N=CC=C3)OC)N	IC50 ~ 100000 nM	Poor binder
T52450	Matrix metalloproteinase-1	BKB5V1	1-(4-Amino-2-methylquinolin-6-yl)-3-(4-benzoylphenyl)urea	Investigative	73055605	C24H20N4O2	396.4	CC1=CC(=C2C=C(C=CC2=N1)NC(=O)NC3=CC=C(C=C3)C(=O)C4=CC=CC=C4)N	IC50 ~ 100000 nM	Poor binder
T52450	Matrix metalloproteinase-1	BKDS50	2-[(4-But-2-ynoxyphenyl)sulfonylamino]-3-(5-phenylmethoxy-1H-indol-3-yl)propanoic Acid	Investigative	11533683	C28H26N2O6S	518.6	CC#CCOC1=CC=C(C=C1)S(=O)(=O)NC(CC2=CNC3=C2C=C(C=C3)OCC4=CC=CC=C4)C(=O)O	IC50 ~ 50000 nM	Poor binder
T52450	Matrix metalloproteinase-1	BKG9M5	4-(4,5-Dihydrooxazol-2-yl)-1-hexyl-1H-1,2,3-triazole	Investigative	44445272	C11H18N4O	222.29	CCCCCCN1C=C(N=N1)C2=NCCO2	IC50 ~ 150000 nM	Poor binder
T52450	Matrix metalloproteinase-1	BKM83T	4-Chlorobenzyl 6-mercaptopicolinate	Investigative	44445261	C13H10ClNO2S	279.74	C1=CC(=S)NC(=C1)C(=O)OCC2=CC=C(C=C2)Cl	IC50 = 126000 nM	Poor binder
T52450	Matrix metalloproteinase-1	BKPV14	N-Hydroxy-N-{1-(1-isobutyl-piperidin-4-ylidenemethyl)-2-[4-(2-methyl-quinolin-4-ylmethoxy)-benzenesulfonyl]-ethyl}-formamide	Investigative	44330147	C30H37N3O5S	551.7	CC1=NC2=CC=CC=C2C(=C1)COC3=CC=C(C=C3)S(=O)(=O)CC(C=C4CCN(CC4)CC(C)C)N(C=O)O	IC50 ~ 100000 nM	Poor binder
T52450	Matrix metalloproteinase-1	BKZ4T1	N-Hydroxy-2-[4-[4-(trifluoromethoxy)benzyloxy]phenylsulfonylamino]acetamide	Investigative	72713862	C16H15F3N2O6S	420.4	C1=CC(=CC=C1COC2=CC=C(C=C2)S(=O)(=O)NCC(=O)NO)OC(F)(F)F	IC50 = 74000 nM	Poor binder
T52450	Matrix metalloproteinase-1	BL2F0S	6-Oxo-1,6-dihydro-pyridine-2-carboxylic acid 4-methyl-benzyl ester	Investigative	44445206	C14H13NO3	243.26	CC1=CC=C(C=C1)COC(=O)C2=CC=CC(=O)N2	IC50 = 65000 nM	Poor binder
T52450	Matrix metalloproteinase-1	BL9W0M	N-[2-[4-(4-Cyanophenyl)phenoxy]ethyl]-N-hydroxyformamide	Investigative	21699977	C16H14N2O3	282.29	C1=CC(=CC=C1C#N)C2=CC=C(C=C2)OCCN(C=O)O	IC50 ~ 50000 nM	Poor binder
T52450	Matrix metalloproteinase-1	BLF02U	4-{3-(Formyl-hydroxy-amino)-4-[4-(4-trifluoromethoxy-phenoxy)-benzenesulfonyl]-butyl}-benzoic acid	Investigative	10166232	C25H22F3NO8S	553.5	C1=CC(=CC=C1CCC(CS(=O)(=O)C2=CC=C(C=C2)OC3=CC=C(C=C3)OC(F)(F)F)N(C=O)O)C(=O)O	IC50 ~ 50000 nM	Poor binder
T52450	Matrix metalloproteinase-1	BLO62C	Prop-2-enyl 3-(3,4-dimethoxyphenyl)-2-[(E)-3-[4-(trifluoromethyl)phenyl]prop-2-enoyl]oxypropanoate	Investigative	71654192	C24H23F3O6	464.4	COC1=C(C=C(C=C1)CC(C(=O)OCC=C)OC(=O)/C=C/C2=CC=C(C=C2)C(F)(F)F)OC	IC50 ~ 100000 nM	Poor binder
T52450	Matrix metalloproteinase-1	BLW39J	N-Hydroxy-2-[4-(3-fluorobenzyloxy)phenylsulfonylamino]acetamide	Investigative	72713865	C15H15FN2O5S	354.4	C1=CC(=CC(=C1)F)COC2=CC=C(C=C2)S(=O)(=O)NCC(=O)NO	IC50 = 61000 nM	Poor binder
T52450	Matrix metalloproteinase-1	BMC9X6	4-{(5Z)-2,4-Dioxo-5-[(2E)-3-phenylprop-2-enylidene]-1,3-thiazolidin-3-yl}butanoic acid	Investigative	1348435	C16H15NO4S	317.4	C1=CC=C(C=C1)/C=C/C=C\\2/C(=O)N(C(=O)S2)CCCC(=O)O	IC50 = 93000 nM	Poor binder
T52450	Matrix metalloproteinase-1	BMI8C2	Isopropyl 6-mercaptopicolinate	Investigative	44445241	C9H11NO2S	197.26	CC(C)OC(=O)C1=CC=CC(=S)N1	IC50 = 121000 nM	Poor binder
T52450	Matrix metalloproteinase-1	BMUX74	2-(5-{(1R)-4-Cyclohexyl-1-[2-(hydroxyamino)-2-oxoethyl]butyl}-1,2,4-oxadiazol-3-yl)isonicotinic acid	Investigative	16748789	C20H26N4O5	402.4	C1CCC(CC1)CCC[C@H](CC(=O)NO)C2=NC(=NO2)C3=NC=CC(=C3)C(=O)O	IC50 ~ 100000 nM	Poor binder
T52450	Matrix metalloproteinase-1	BN6V9X	N-[1-[(4S)-2,2-Dimethyl-1,3-dioxolan-4-yl]-3-[4-[4-(trifluoromethoxy)phenoxy]phenyl]sulfonylpropan-2-yl]-N-hydroxyformamide	Investigative	11027718	C22H24F3NO8S	519.5	CC1(OC[C@@H](O1)CC(CS(=O)(=O)C2=CC=C(C=C2)OC3=CC=C(C=C3)OC(F)(F)F)N(C=O)O)C	IC50 ~ 50000 nM	Poor binder
T52450	Matrix metalloproteinase-1	BNEM74	2,5-Difluorobenzyl 6-oxo-1,6-dihydropyridine-2-carboxylate	Investigative	44445217	C13H9F2NO3	265.21	C1=CC(=O)NC(=C1)C(=O)OCC2=C(C=CC(=C2)F)F	IC50 = 70000 nM	Poor binder
T52450	Matrix metalloproteinase-1	BNH40K	trans-2-Aminocyclohexylcarbamoylphosphonic acid	Investigative	24807817	C7H15N2O4P	222.18	C1CC[C@H]([C@@H](C1)N)NC(=O)P(=O)(O)O	IC50 = 90000 nM	Poor binder
T52450	Matrix metalloproteinase-1	BNOK60	2-Fluorobenzyl 6-oxo-1,6-dihydropyridine-2-carboxylate	Investigative	44445213	C13H10FNO3	247.22	C1=CC=C(C(=C1)COC(=O)C2=CC=CC(=O)N2)F	IC50 = 64000 nM	Poor binder
T52450	Matrix metalloproteinase-1	BNP8H6	(2R,3R)-N-(2-(4-Benzylthiophen-2-yl)ethyl)-2,3-dihydroxy-4-oxo-4-(2-phenylpyrrolidin-1-yl)butanamide	Investigative	46184724	C27H30N2O4S	478.6	C1CC(N(C1)C(=O)[C@@H]([C@H](C(=O)NCCC2=CC(=CS2)CC3=CC=CC=C3)O)O)C4=CC=CC=C4	Ki ~ 50000 nM	Poor binder
T52450	Matrix metalloproteinase-1	BNQK37	MMP Inhibitor, 3	Investigative	50991679	C29H31N3O7S	565.6	C1=CC=C(C=C1)C2=CSC(=C2)C3=CC=C(C=C3)CCC(=O)N[C@@H](CCC(=O)O)C(=O)N[C@H](CCC(=O)O)C(=O)N	Ki ~ 100000 nM	Poor binder
T52450	Matrix metalloproteinase-1	BNTY08	(E)-3-((2-Cinnamyl-2H-tetrazol-5-yl)methyl)pyridine	Investigative	44445281	C16H15N5	277.32	C1=CC=C(C=C1)/C=C/CN2N=C(N=N2)CC3=CN=CC=C3	IC50 ~ 150000 nM	Poor binder
T52450	Matrix metalloproteinase-1	BNU1Q2	Cyclohexyl 6-mercaptopicolinate	Investigative	44445243	C12H15NO2S	237.32	C1CCC(CC1)OC(=O)C2=CC=CC(=S)N2	IC50 = 102000 nM	Poor binder
T52450	Matrix metalloproteinase-1	BO8W7V	N-Hydroxy-N-[2-[4-[4-(trifluoromethoxy)phenoxy]phenyl]sulfonyl-1-[(4S,5S)-2,2,5-trimethyl-1,3-dioxolan-4-yl]ethyl]formamide	Investigative	9871305	C22H24F3NO8S	519.5	C[C@H]1[C@@H](OC(O1)(C)C)C(CS(=O)(=O)C2=CC=C(C=C2)OC3=CC=C(C=C3)OC(F)(F)F)N(C=O)O	IC50 ~ 50000 nM	Poor binder
T52450	Matrix metalloproteinase-1	BO9WE6	4-(4,5-Dihydrooxazol-2-yl)-1-heptyl-1H-1,2,3-triazole	Investigative	44445273	C12H20N4O	236.31	CCCCCCCN1C=C(N=N1)C2=NCCO2	IC50 ~ 150000 nM	Poor binder
T52450	Matrix metalloproteinase-1	BOK9I1	N-[(2S,4S)-4-(5-Fluoropyrimidin-2-yl)-2-methyl-1-[4-[2-[3-methyl-5-(trifluoromethyl)pyridin-2-yl]ethyl]piperidin-1-yl]sulfonylpentan-2-yl]-N-hydroxyformamide	Investigative	53326761	C25H33F4N5O4S	575.6	CC1=CC(=CN=C1CCC2CCN(CC2)S(=O)(=O)C[C@](C)(C[C@H](C)C3=NC=C(C=N3)F)N(C=O)O)C(F)(F)F	IC50 ~ 79000 nM	Poor binder
T52450	Matrix metalloproteinase-1	BOL2C9	N-Methyl-2-[3-(5-thioxo-4,5-dihydro-[1,3,4]thiadiazol-2-yl)-ureido]-acetamide	Investigative	10610500	C6H9N5O2S2	247.3	CNC(=O)CNC(=O)NC1=NNC(=S)S1	Ki ~ 100000 nM	Poor binder
T52450	Matrix metalloproteinase-1	BORP07	5-(3-Pyridylmethyl)-1H-tetrazole	Investigative	28602444	C7H7N5	161.16	C1=CC(=CN=C1)CC2=NNN=N2	IC50 ~ 150000 nM	Poor binder
T52450	Matrix metalloproteinase-1	BOZJ91	N-Hydroxy-N-{3-hydroxy-2-hydroxymethyl-1-[4-(4-trifluoromethoxy-phenoxy)-benzenesulfonylmethyl]-propyl}-formamide	Investigative	10961828	C19H20F3NO8S	479.4	C1=CC(=CC=C1OC2=CC=C(C=C2)S(=O)(=O)CC(C(CO)CO)N(C=O)O)OC(F)(F)F	IC50 ~ 50000 nM	Poor binder
T52450	Matrix metalloproteinase-1	BP0K8E	N-Hydroxy-N-{1-(tetrahydro-furan-2-yl)-2-[4-(4-trifluoromethoxy-phenoxy)-benzenesulfonyl]-ethyl}-formamide	Investigative	9826199	C20H20F3NO7S	475.4	C1CC(OC1)C(CS(=O)(=O)C2=CC=C(C=C2)OC3=CC=C(C=C3)OC(F)(F)F)N(C=O)O	IC50 = 50000 nM	Poor binder
T52450	Matrix metalloproteinase-1	BP4CV9	3-(3,4-Dimethoxyphenyl)-2-[(E)-3-(4-methylphenyl)prop-2-enoyl]oxypropanoic acid	Investigative	71654518	C21H22O6	370.4	CC1=CC=C(C=C1)/C=C/C(=O)OC(CC2=CC(=C(C=C2)OC)OC)C(=O)O	IC50 ~ 100000 nM	Poor binder
T52450	Matrix metalloproteinase-1	BP53DZ	(S)-2-((R)-2-Acetylamino-3-mercapto-propionylamino)-3-phenyl-propionamide	Investigative	44299709	C14H19N3O3S	309.39	CC(=O)N[C@@H](CS)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N	IC50 ~ 100000 nM	Poor binder
T52450	Matrix metalloproteinase-1	BP5Y8B	[2-(2-Cyclohexyl-1-phenethylcarbamoyl-ethylcarbamoyl)-5-p-tolyl-pentyl]-phosphonic acid	Investigative	10414974	C30H43N2O5P	542.6	CC1=CC=C(C=C1)CCC[C@H](CP(=O)(O)O)C(=O)N[C@@H](CC2CCCCC2)C(=O)NCCC3=CC=CC=C3	Ki = 100000 nM	Poor binder
T52450	Matrix metalloproteinase-1	BP6NW4	(Cyclobutylamino)carbonylphosphonic acid	Investigative	11194666	C5H10NO4P	179.11	C1CC(C1)NC(=O)P(=O)(O)O	IC50 ~ 100000 nM	Poor binder
T52450	Matrix metalloproteinase-1	BPJ4S9	N-Hydroxy-N-{3-(4-methanesulfonyl-piperazin-1-yl)-1-[4-(4-trifluoromethoxy-phenoxy)-benzenesulfonylmethyl]-propyl}-formamide	Investigative	10282084	C23H28F3N3O8S2	595.6	CS(=O)(=O)N1CCN(CC1)CCC(CS(=O)(=O)C2=CC=C(C=C2)OC3=CC=C(C=C3)OC(F)(F)F)N(C=O)O	IC50 = 50000 nM	Poor binder
T52450	Matrix metalloproteinase-1	BPM2J0	3-Methoxybenzyl 6-oxo-1,6-dihydropyridine-2-carboxylate	Investigative	44445209	C14H13NO4	259.26	COC1=CC=CC(=C1)COC(=O)C2=CC=CC(=O)N2	IC50 = 69000 nM	Poor binder
T52450	Matrix metalloproteinase-1	BPWS17	N*4*-Hydroxy-2-(4-hydroxy-benzyl)-N*1*-indan-1-yl-succinamide	Investigative	15524387	C20H22N2O4	354.4	C1CC2=CC=CC=C2[C@@H]1NC(=O)[C@H](CC3=CC=C(C=C3)O)CC(=O)NO	Ki = 75000 nM	Poor binder
T52450	Matrix metalloproteinase-1	BQH92J	N-{2,3-Dihydroxy-1-[4-(4-trifluoromethoxy-phenoxy)-benzenesulfonylmethyl]-propyl}-N-hydroxy-formamide	Investigative	44314322	C18H18F3NO8S	465.4	C1=CC(=CC=C1OC2=CC=C(C=C2)S(=O)(=O)CC([C@@H](CO)O)N(C=O)O)OC(F)(F)F	IC50 ~ 50000 nM	Poor binder
T52450	Matrix metalloproteinase-1	BQK5W3	4-Methoxybenzyl 6-mercaptopicolinate	Investigative	44445252	C14H13NO3S	275.32	COC1=CC=C(C=C1)COC(=O)C2=CC=CC(=S)N2	IC50 = 108000 nM	Poor binder
T52450	Matrix metalloproteinase-1	BQM30A	N-[(2S,4S)-1-[4-[2-[2-Chloro-4-(trifluoromethyl)phenyl]ethyl]piperidin-1-yl]sulfonyl-4-(5-fluoropyrimidin-2-yl)-2-methylpentan-2-yl]-N-hydroxyformamide	Investigative	53325497	C25H31ClF4N4O4S	595	C[C@@H](C[C@@](C)(CS(=O)(=O)N1CCC(CC1)CCC2=C(C=C(C=C2)C(F)(F)F)Cl)N(C=O)O)C3=NC=C(C=N3)F	IC50 ~ 100000 nM	Poor binder
T52450	Matrix metalloproteinase-1	BQX1W6	Cinnamyl 6-oxo-1,6-dihydropyridine-2-carboxylate	Investigative	44445228	C15H13NO3	255.27	C1=CC=C(C=C1)/C=C/COC(=O)C2=CC=CC(=O)N2	IC50 = 86000 nM	Poor binder
T52450	Matrix metalloproteinase-1	BRCZ16	1-Benzyl-4-(4,5-dihydrooxazol-2-yl)-1H-1,2,3-triazole	Investigative	44445274	C12H12N4O	228.25	C1COC(=N1)C2=CN(N=N2)CC3=CC=CC=C3	IC50 ~ 150000 nM	Poor binder
T52450	Matrix metalloproteinase-1	BRD5Z7	(2r,3r)-4-[4-(2-Chlorophenyl)piperazin-1-Yl]-2,3-Dihydroxy-4-Oxo-N-(2-Thiophen-2-Ylethyl)butanamide	Investigative	11640694	C20H24ClN3O4S	437.9	C1CN(CCN1C2=CC=CC=C2Cl)C(=O)[C@@H]([C@H](C(=O)NCCC3=CC=CS3)O)O	Ki ~ 90000 nM	Poor binder
T52450	Matrix metalloproteinase-1	BRI81Y	CID 10874819	Investigative	10874819	C21H22F3NO8S	505.5	CC1(OC[C@H](O1)[C@@H](CS(=O)(=O)C2=CC=C(C=C2)OC3=CC=C(C=C3)OC(F)(F)F)N(C=O)O)C	IC50 = 50000 nM	Poor binder
T52450	Matrix metalloproteinase-1	BRTE39	Benzo[d][1,3]dioxol-5-ylmethyl 6-oxo-1,6-dihydropyridine-2-carboxylate	Investigative	44445231	C14H11NO5	273.24	C1OC2=C(O1)C=C(C=C2)COC(=O)C3=CC=CC(=O)N3	IC50 = 128000 nM	Poor binder
T52450	Matrix metalloproteinase-1	BS2Q0X	N-Hydroxy-N-{1-phenyl-2-[4-(4-trifluoromethoxy-phenoxy)-benzenesulfonyl]-ethyl}-formamide	Investigative	11038175	C22H18F3NO6S	481.4	C1=CC=C(C=C1)C(CS(=O)(=O)C2=CC=C(C=C2)OC3=CC=C(C=C3)OC(F)(F)F)N(C=O)O	IC50 ~ 50000 nM	Poor binder
T52450	Matrix metalloproteinase-1	BS42BZ	N-Hydroxy-N-[2-[4-(4-trifluoromethoxy-phenoxy)-benzenesulfonyl]-1-(3,4,4-trimethyl-2,5-dioxo-imidazolidin-1-ylmethyl)-ethyl]-formamide	Investigative	11049982	C23H24F3N3O8S	559.5	CC1(C(=O)N(C(=O)N1C)CC(CS(=O)(=O)C2=CC=C(C=C2)OC3=CC=C(C=C3)OC(F)(F)F)N(C=O)O)C	IC50 ~ 50000 nM	Poor binder
T52450	Matrix metalloproteinase-1	BS9D5V	3-Hydroxy-5-[4-(4-methylsulfanylphenyl)phenyl]pentanoic acid	Investigative	44626353	C18H20O3S	316.4	CSC1=CC=C(C=C1)C2=CC=C(C=C2)CCC(CC(=O)O)O	IC50 ~ 98000 nM	Poor binder
T52450	Matrix metalloproteinase-1	BSD4C0	Cyclobutyl 6-mercaptopicolinate	Investigative	44445242	C10H11NO2S	209.27	C1CC(C1)OC(=O)C2=CC=CC(=S)N2	IC50 = 135000 nM	Poor binder
T52450	Matrix metalloproteinase-1	BSD50Z	4-(Trifluoromethyl)benzyl 6-mercaptopicolinate	Investigative	44445250	C14H10F3NO2S	313.3	C1=CC(=S)NC(=C1)C(=O)OCC2=CC=C(C=C2)C(F)(F)F	IC50 ~ 150000 nM	Poor binder
T52450	Matrix metalloproteinase-1	BSJ45U	Morpholin-4-ylcarbonylphosphonic acid	Investigative	44328189	C5H10NO5P	195.11	C1COCCN1C(=O)P(=O)(O)O	IC50 = 50000 nM	Poor binder
T52450	Matrix metalloproteinase-1	BSX0L7	3-(3,4-Dimethoxyphenyl)-2-[(E)-3-(4-methoxyphenyl)prop-2-enoyl]oxypropanoic acid	Investigative	71652359	C21H22O7	386.4	COC1=CC=C(C=C1)/C=C/C(=O)OC(CC2=CC(=C(C=C2)OC)OC)C(=O)O	IC50 ~ 100000 nM	Poor binder
T52450	Matrix metalloproteinase-1	BT05YX	(2S)-N-[(2S)-1-Oxo-1-[(2-sulfanylidene-3H-1,3,4-thiadiazol-5-yl)amino]propan-2-yl]-3-phenyl-2-(quinolin-8-ylsulfonylamino)propanamide	Investigative	90663081	C23H22N6O4S3	542.7	C[C@@H](C(=O)NC1=NNC(=S)S1)NC(=O)[C@H](CC2=CC=CC=C2)NS(=O)(=O)C3=CC=CC4=C3N=CC=C4	Ki = 74000 nM	Poor binder
T52450	Matrix metalloproteinase-1	BT12UN	2-{Isopropoxy[(4-methoxyphenyl)sulfonyl]amino}-N-hydroxyacetamide	Investigative	44423677	C12H18N2O6S	318.35	CC(C)ON(CC(=O)NO)S(=O)(=O)C1=CC=C(C=C1)OC	IC50 = 110000 nM	Poor binder
T52450	Matrix metalloproteinase-1	BT13RF	6-(4-Chloro-phenyl)-3-{2-cyclohexyl-1-[2-(4-sulfamoyl-phenyl)-ethylcarbamoyl]-ethylcarbamoyl}-hexanoic acid	Investigative	44314970	C30H40ClN3O6S	606.2	C1CCC(CC1)C[C@@H](C(=O)NCCC2=CC=C(C=C2)S(=O)(=O)N)NC(=O)[C@H](CCCC3=CC=C(C=C3)Cl)CC(=O)O	Ki = 54954.09 nM	Poor binder
T52450	Matrix metalloproteinase-1	BT16SP	Benzyl 6-Benzyl-5,7-Dioxo-6,7-Dihydro-5h-[1,3]thiazolo[3,2-C]pyrimidine-2-Carboxylate	Investigative	9896504	C21H16N2O4S	392.4	C1=CC=C(C=C1)CN2C(=O)C=C3N(C2=O)C=C(S3)C(=O)OCC4=CC=CC=C4	IC50 ~ 100000 nM	Poor binder
T52450	Matrix metalloproteinase-1	BT2BH7	N-Hydroxy-N-{1-pyridin-2-yl-2-[4-(4-trifluoromethoxy-phenoxy)-benzenesulfonyl]-ethyl}-formamide	Investigative	10972891	C21H17F3N2O6S	482.4	C1=CC=NC(=C1)C(CS(=O)(=O)C2=CC=C(C=C2)OC3=CC=C(C=C3)OC(F)(F)F)N(C=O)O	IC50 ~ 50000 nM	Poor binder
T52450	Matrix metalloproteinase-1	BTE7I6	6-Mercapto-pyridine-2-carboxylic acid biphenyl-3-ylmethyl ester	Investigative	44445266	C19H15NO2S	321.4	C1=CC=C(C=C1)C2=CC=CC(=C2)COC(=O)C3=CC=CC(=S)N3	IC50 = 75000 nM	Poor binder
T52450	Matrix metalloproteinase-1	BTE9Q1	N-(4-Amino-2-methylquinolin-6-yl)-4-quinolin-8-ylbenzamide	Investigative	73055905	C26H20N4O	404.5	CC1=CC(=C2C=C(C=CC2=N1)NC(=O)C3=CC=C(C=C3)C4=CC=CC5=C4N=CC=C5)N	IC50 ~ 100000 nM	Poor binder
T52450	Matrix metalloproteinase-1	BTV5U3	4-Cyano-N-(2-piperidin-1-yl-phenyl)-benzamide	Investigative	7550925	C19H19N3O	305.4	C1CCN(CC1)C2=CC=CC=C2NC(=O)C3=CC=C(C=C3)C#N	IC50 = 55000 nM	Poor binder
T52450	Matrix metalloproteinase-1	BTVA75	N*4*-Hydroxy-N*1*-(2-hydroxy-indan-1-yl)-2-(3-methoxy-benzyl)-succinamide	Investigative	15524389	C21H24N2O5	384.4	COC1=CC=CC(=C1)C[C@H](CC(=O)NO)C(=O)N[C@@H]2[C@@H](CC3=CC=CC=C23)O	Ki = 95500 nM	Poor binder
T52450	Matrix metalloproteinase-1	BU5E3S	3-(3,4-Dimethoxyphenyl)-2-[(E)-3-naphthalen-2-ylprop-2-enoyl]oxypropanoic acid	Investigative	71652362	C24H22O6	406.4	COC1=C(C=C(C=C1)CC(C(=O)O)OC(=O)/C=C/C2=CC3=CC=CC=C3C=C2)OC	IC50 ~ 100000 nM	Poor binder
T52450	Matrix metalloproteinase-1	BU5T8R	(1R,2S,5R)-2-[4-(4-Chlorophenyl)phenyl]sulfanyl-5-[(4-oxo-1,2,3-benzotriazin-3-yl)methyl]cyclopentane-1-carboxylic acid	Investigative	9891814	C26H22ClN3O3S	492	C1C[C@@H]([C@H]([C@@H]1CN2C(=O)C3=CC=CC=C3N=N2)C(=O)O)SC4=CC=C(C=C4)C5=CC=C(C=C5)Cl	IC50 ~ 100000 nM	Poor binder
T52450	Matrix metalloproteinase-1	BU72GZ	N-[(3S,4S)-1-(6-Aminohexanoyl)-4-hydroxypyrrolidin-3-yl]-4-phenoxybenzenesulfonamide;hydrochloride	Investigative	71680867	C22H30ClN3O5S	484	C1[C@@H]([C@H](CN1C(=O)CCCCCN)O)NS(=O)(=O)C2=CC=C(C=C2)OC3=CC=CC=C3.Cl	Ki ~ 50000 nM	Poor binder
T52450	Matrix metalloproteinase-1	BU7EQ0	(2R)-2-Amino-N-[(2S)-1-[[(2S)-1-(benzylamino)-4-methyl-1-oxopentan-2-yl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]-4-methylpentanamide	Investigative	44356688	C30H41N5O3	519.7	CC(C)C[C@H](C(=O)N[C@@H](CC1=CNC2=CC=CC=C21)C(=O)N[C@@H](CC(C)C)C(=O)NCC3=CC=CC=C3)N	IC50 ~ 60000 nM	Poor binder
T52450	Matrix metalloproteinase-1	BUHO01	3-(1-Carbamoyl-2-cyclohexyl-ethylcarbamoyl)-6-phenyl-hexanoic acid	Investigative	44314995	C22H32N2O4	388.5	C1CCC(CC1)C[C@@H](C(=O)N)NC(=O)[C@H](CCCC2=CC=CC=C2)CC(=O)O	Ki = 100000 nM	Poor binder
T52450	Matrix metalloproteinase-1	BUK1T6	3-(Trifluoromethyl)benzyl 6-mercaptopicolinate	Investigative	44445249	C14H10F3NO2S	313.3	C1=CC(=CC(=C1)C(F)(F)F)COC(=O)C2=CC=CC(=S)N2	IC50 = 134000 nM	Poor binder
T52450	Matrix metalloproteinase-1	BV1HA4	Hydroxysulfonamide 48	Investigative	23644663	CH2Cl3NO3S	214.5	C(S(=O)(=O)NO)(Cl)(Cl)Cl	Ki ~ 100000 nM	Poor binder
T52450	Matrix metalloproteinase-1	BV7YC8	3-Hydroxy-5-[4-(4-phenoxyphenyl)phenyl]pentanoic acid	Investigative	45483023	C23H22O4	362.4	C1=CC=C(C=C1)OC2=CC=C(C=C2)C3=CC=C(C=C3)CCC(CC(=O)O)O	IC50 ~ 98000 nM	Poor binder
T52450	Matrix metalloproteinase-1	BVA15M	Dipotassium;2-[[(2S)-2-[[(2S)-2-[[ethoxy(oxido)phosphoryl]amino]-4-methylpentanoyl]amino]propanoyl]amino]acetate	Investigative	14505615	C13H24K2N3O7P	443.52	CCOP(=O)(N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)NCC(=O)[O-])[O-].[K+].[K+]	Ki = 140000 nM	Poor binder
T52450	Matrix metalloproteinase-1	BVZ90P	(Isopropylamino)carbonylphosphonic acid	Investigative	11147931	C4H10NO4P	167.1	CC(C)NC(=O)P(=O)(O)O	IC50 = 50000 nM	Poor binder
T52450	Matrix metalloproteinase-1	BW1KQ0	4-Phenoxybutyl 6-mercaptopicolinate	Investigative	44445253	C16H17NO3S	303.4	C1=CC=C(C=C1)OCCCCOC(=O)C2=CC=CC(=S)N2	IC50 = 138000 nM	Poor binder
T52450	Matrix metalloproteinase-1	BW31OG	(Ethylamino)carbonylphosphonic acid	Investigative	11205873	C3H8NO4P	153.07	CCNC(=O)P(=O)(O)O	IC50 = 50000 nM	Poor binder
T52450	Matrix metalloproteinase-1	BW35RO	(2R)-2-(4-Fluoro-3,5-dimethylanilino)-6-[1-(4-fluorophenyl)propylamino]-N-hydroxyhexanamide	Investigative	57345500	C23H31F2N3O2	419.5	CCC(C1=CC=C(C=C1)F)NCCCC[C@H](C(=O)NO)NC2=CC(=C(C(=C2)C)F)C	Ki ~ 50000 nM	Poor binder
T52450	Matrix metalloproteinase-1	BW53GL	(2S)-2-[[5-(Dimethylamino)naphthalen-1-yl]sulfonylamino]-N-[(2S)-1-oxo-1-[(2-sulfanylidene-3H-1,3,4-thiadiazol-5-yl)amino]propan-2-yl]-3-phenylpropanamide	Investigative	90663077	C26H28N6O4S3	584.7	C[C@@H](C(=O)NC1=NNC(=S)S1)NC(=O)[C@H](CC2=CC=CC=C2)NS(=O)(=O)C3=CC=CC4=C3C=CC=C4N(C)C	Ki = 87000 nM	Poor binder
T52450	Matrix metalloproteinase-1	BW8Z6H	Dipotassium;2-[[2-[[(2S,3S)-2-[[ethoxy(oxido)phosphoryl]amino]-3-methylpentanoyl]amino]-3-(4-phenylmethoxyphenyl)propanoyl]amino]-3-phenylpropanoate	Investigative	54586055	C33H40K2N3O8P	715.9	CC[C@H](C)[C@@H](C(=O)NC(CC1=CC=C(C=C1)OCC2=CC=CC=C2)C(=O)NC(CC3=CC=CC=C3)C(=O)[O-])NP(=O)([O-])OCC.[K+].[K+]	Ki = 120000 nM	Poor binder
T52450	Matrix metalloproteinase-1	BW9K1L	4-Benzylsulfanyl-2-(4''-bromo-biphenyl-4-sulfonylamino)-butyric acid	Investigative	10506147	C23H22BrNO4S2	520.5	C1=CC=C(C=C1)CSCCC(C(=O)O)NS(=O)(=O)C2=CC=C(C=C2)C3=CC=C(C=C3)Br	IC50 = 56000 nM	Poor binder
T52450	Matrix metalloproteinase-1	BX05JE	Prop-2-enyl 2-[(E)-3-(4-chlorophenyl)prop-2-enoyl]oxy-3-(3,4-dimethoxyphenyl)propanoate	Investigative	71654194	C23H23ClO6	430.9	COC1=C(C=C(C=C1)CC(C(=O)OCC=C)OC(=O)/C=C/C2=CC=C(C=C2)Cl)OC	IC50 ~ 100000 nM	Poor binder
T52450	Matrix metalloproteinase-1	BX1NG5	Phenethylcarbamoylphosphonic Acid	Investigative	9794947	C9H12NO4P	229.17	C1=CC=C(C=C1)CCNC(=O)P(=O)(O)O	IC50 = 80000 nM	Poor binder
T52450	Matrix metalloproteinase-1	BX34RO	N-(4-Amino-2-methylquinolin-6-yl)-3-quinolin-6-ylbenzamide	Investigative	73055906	C26H20N4O	404.5	CC1=CC(=C2C=C(C=CC2=N1)NC(=O)C3=CC=CC(=C3)C4=CC5=C(C=C4)N=CC=C5)N	IC50 ~ 100000 nM	Poor binder
T52450	Matrix metalloproteinase-1	BX78KQ	(R)-2-(4-Fluoro-3,5-dimethylphenoxy)-6-(4-fluorobenzylamino)-N-hydroxyhexanamide	Investigative	54580973	C21H26F2N2O3	392.4	CC1=CC(=CC(=C1F)C)O[C@H](CCCCNCC2=CC=C(C=C2)F)C(=O)NO	Ki ~ 50000 nM	Poor binder
T52450	Matrix metalloproteinase-1	BX7RZ0	3-((2-(3-Phenylpropyl)-2H-tetrazol-5-yl)methyl)pyridine	Investigative	44445280	C16H17N5	279.34	C1=CC=C(C=C1)CCCN2N=C(N=N2)CC3=CN=CC=C3	IC50 ~ 150000 nM	Poor binder
T52450	Matrix metalloproteinase-1	BX8V6Y	N-[(2S,4S)-1-[4-[2-(2-Chloro-4-methylsulfonylphenyl)ethyl]piperidin-1-yl]sulfonyl-4-(5-fluoropyrimidin-2-yl)-2-methylpentan-2-yl]-N-hydroxyformamide	Investigative	53320227	C25H34ClFN4O6S2	605.1	C[C@@H](C[C@@](C)(CS(=O)(=O)N1CCC(CC1)CCC2=C(C=C(C=C2)S(=O)(=O)C)Cl)N(C=O)O)C3=NC=C(C=N3)F	IC50 ~ 70000 nM	Poor binder
T52450	Matrix metalloproteinase-1	BXC13G	Secoisolariciresinol	Investigative	65373	C20H26O6	362.4	COC1=C(C=CC(=C1)C[C@@H](CO)[C@@H](CC2=CC(=C(C=C2)O)OC)CO)O	IC50 = 50120 nM	Poor binder
T52450	Matrix metalloproteinase-1	BXG18E	Dipotassium;2-[[(2S)-2-[[(2S,3S)-2-[[ethoxy(oxido)phosphoryl]amino]-3-methylpentanoyl]amino]propanoyl]amino]acetate	Investigative	73349984	C13H24K2N3O7P	443.52	CC[C@H](C)[C@@H](C(=O)N[C@@H](C)C(=O)NCC(=O)[O-])NP(=O)([O-])OCC.[K+].[K+]	Ki = 130000 nM	Poor binder
T52450	Matrix metalloproteinase-1	BXIN13	(4S)-5-Amino-4-[[(2S)-4-carboxy-2-[3-(4-thiophen-2-ylphenyl)propanoylamino]butanoyl]amino]-5-oxopentanoic acid	Investigative	50991424	C23H27N3O7S	489.5	C1=CSC(=C1)C2=CC=C(C=C2)CCC(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N	Ki ~ 100000 nM	Poor binder
T52450	Matrix metalloproteinase-1	BXS9P4	4-Bromobenzyl 6-oxo-1,6-dihydropyridine-2-carboxylate	Investigative	44445226	C13H10BrNO3	308.13	C1=CC(=O)NC(=C1)C(=O)OCC2=CC=C(C=C2)Br	IC50 = 81000 nM	Poor binder
T52450	Matrix metalloproteinase-1	BXW5Y2	Pentan-3-ylcarbamoylphosphonic Acid	Investigative	11367571	C6H14NO4P	195.15	CCC(CC)NC(=O)P(=O)(O)O	IC50 = 80000 nM	Poor binder
T52450	Matrix metalloproteinase-1	BY0QU5	(3R)-6-Cyclohexyl-N-hydroxy-3-(3-{[(methylsulfonyl)amino]-methyl}-1,2,4-oxadiazol-5-yl)hexanamide	Investigative	10271604	C16H28N4O5S	388.5	CS(=O)(=O)NCC1=NOC(=N1)[C@H](CCCC2CCCCC2)CC(=O)NO	IC50 ~ 100000 nM	Poor binder
T52450	Matrix metalloproteinase-1	BY1JD8	N-(4-Amino-2-methylquinolin-6-yl)-4-phenoxybenzamide	Investigative	73054451	C23H19N3O2	369.4	CC1=CC(=C2C=C(C=CC2=N1)NC(=O)C3=CC=C(C=C3)OC4=CC=CC=C4)N	IC50 ~ 100000 nM	Poor binder
T52450	Matrix metalloproteinase-1	BY6OF9	2-(4-Oxo-4H-benzo[d][1,2,3]triazin-3-ylmethyl)-5-[4-(1H-[1,2,3]triazol-4-yl)-phenylsulfanyl]-cyclopentanecarboxylic acid	Investigative	44350116	C22H20N6O3S	448.5	C1C[C@@H]([C@H]([C@@H]1CN2C(=O)C3=CC=CC=C3N=N2)C(=O)O)SC4=CC=C(C=C4)C5=NNN=C5	IC50 ~ 100000 nM	Poor binder
T52450	Matrix metalloproteinase-1	BY8QH0	Piperidin-1-ylcarbonylphosphonic acid	Investigative	44328155	C6H12NO4P	193.14	C1CCN(CC1)C(=O)P(=O)(O)O	IC50 = 70000 nM	Poor binder
T52450	Matrix metalloproteinase-1	BYSM39	(+/-)-2-[2-(Biphenyl-4-sulfonyl)phenyl]propionic Acid	Investigative	44479702	C21H18O4S	366.4	CC(C1=CC=CC=C1S(=O)(=O)C2=CC=C(C=C2)C3=CC=CC=C3)C(=O)O	IC50 = 51000 nM	Poor binder
T52450	Matrix metalloproteinase-1	BYV2D6	(1R,2S,5R)-2-[4-(4-Chlorophenyl)phenyl]sulfanyl-5-[(4,4-dimethyl-2,5-dioxoimidazolidin-1-yl)methyl]cyclopentane-1-carboxylic acid	Investigative	44349787	C24H25ClN2O4S	473	CC1(C(=O)N(C(=O)N1)C[C@@H]2CC[C@@H]([C@H]2C(=O)O)SC3=CC=C(C=C3)C4=CC=C(C=C4)Cl)C	IC50 = 70000 nM	Poor binder
T52450	Matrix metalloproteinase-1	BZ7R9X	(4R)-3-[4-(4-Fluorophenoxy)phenyl]sulfonyl-N-hydroxy-1,3-thiazolidine-4-carboxamide	Investigative	57394850	C16H15FN2O5S2	398.4	C1[C@H](N(CS1)S(=O)(=O)C2=CC=C(C=C2)OC3=CC=C(C=C3)F)C(=O)NO	IC50 ~ 50000 nM	Poor binder
T52450	Matrix metalloproteinase-1	BZ8IT5	2,4,5-Trifluorobenzyl 6-mercaptopicolinate	Investigative	44445258	C13H8F3NO2S	299.27	C1=CC(=S)NC(=C1)C(=O)OCC2=CC(=C(C=C2F)F)F	IC50 = 124000 nM	Poor binder
T52450	Matrix metalloproteinase-1	BZ97RT	3-Phenylpropyl 6-mercaptopicolinate	Investigative	44445246	C15H15NO2S	273.4	C1=CC=C(C=C1)CCCOC(=O)C2=CC=CC(=S)N2	IC50 = 95000 nM	Poor binder
T52450	Matrix metalloproteinase-1	BZRO48	2-[[4-(4-Bromophenyl)phenyl]sulfonylamino]acetic Acid	Investigative	10832925	C14H12BrNO4S	370.22	C1=CC(=CC=C1C2=CC=C(C=C2)Br)S(=O)(=O)NCC(=O)O	IC50 = 50000 nM	Poor binder
T52450	Matrix metalloproteinase-1	D04GOO	N1,N3-bis(3-methoxybenzyl)isophthalamide	Investigative	10111838	C24H24N2O4	404.5	COC1=CC=CC(=C1)CNC(=O)C2=CC(=CC=C2)C(=O)NCC3=CC(=CC=C3)OC	IC50 ~ 100000 nM	Poor binder
T52450	Matrix metalloproteinase-1	D04UBY	5-(3'-cyanobiphenyl-4-yl)-3-hydroxypentanoic acid	Investigative	45483018	C18H17NO3	295.3	C1=CC(=CC(=C1)C2=CC=C(C=C2)CCC(CC(=O)O)O)C#N	IC50 ~ 98000 nM	Poor binder
T52450	Matrix metalloproteinase-1	D05THD	2-(Biphenyl-4-ylsulfonyl)N-hydroxybenzamide	Investigative	44478925	C19H15NO4S	353.4	C1=CC=C(C=C1)C2=CC=C(C=C2)S(=O)(=O)C3=CC=CC=C3C(=O)NO	IC50 = 73000 nM	Poor binder
T52450	Matrix metalloproteinase-1	D0A0FY	N-Hydroxy-2-(4-methoxy-benzenesulfonyl)benzamide	Investigative	44479457	C14H13NO5S	307.32	COC1=CC=C(C=C1)S(=O)(=O)C2=CC=CC=C2C(=O)NO	IC50 ~ 100000 nM	Poor binder
T52450	Matrix metalloproteinase-1	D0B3UN	RXP470.1	Investigative	44580458	C35H35BrClN4O10P	818	C1=CC(=CC(=C1)Cl)C2=CC=C(C=C2)C3=NOC(=C3)C[C@H](CP(=O)(C4=CC=C(C=C4)Br)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N	Ki = 67000 nM	Poor binder
T52450	Matrix metalloproteinase-1	D0C1EQ	2-(2-(biphenyl-4-yl)ethylthio)acetic acid	Investigative	20348772	C16H16O2S	272.4	C1=CC=C(C=C1)C2=CC=C(C=C2)CCSCC(=O)O	IC50 ~ 98000 nM	Poor binder
T52450	Matrix metalloproteinase-1	D0F4UT	2-(2-(biphenyl-4-yl)ethylsulfinyl)acetic acid	Investigative	21496278	C16H16O3S	288.4	C1=CC=C(C=C1)C2=CC=C(C=C2)CCS(=O)CC(=O)O	IC50 ~ 98000 nM	Poor binder
T52450	Matrix metalloproteinase-1	D0G3YZ	(+/-)5-(biphenyl-4-yl)-3-hydroxypentanoic acid	Investigative	11391583	C17H18O3	270.32	C1=CC=C(C=C1)C2=CC=C(C=C2)CCC(CC(=O)O)O	IC50 ~ 98000 nM	Poor binder
T52450	Matrix metalloproteinase-1	D0K0YX	5-(4'-cyanobiphenyl-4-yl)-3-hydroxypentanoic acid	Investigative	44626352	C18H17NO3	295.3	C1=CC(=CC=C1CCC(CC(=O)O)O)C2=CC=C(C=C2)C#N	IC50 ~ 98000 nM	Poor binder
T52450	Matrix metalloproteinase-1	D0LB0N	5-(biphenyl-4-yl)-3-oxopentanoic acid	Investigative	45483008	C17H16O3	268.31	C1=CC=C(C=C1)C2=CC=C(C=C2)CCC(=O)CC(=O)O	IC50 ~ 98000 nM	Poor binder
T52450	Matrix metalloproteinase-1	D0LM2K	2-(2-(biphenyl-4-yl)ethylsulfonyl)acetic acid	Investigative	45483015	C16H16O4S	304.4	C1=CC=C(C=C1)C2=CC=C(C=C2)CCS(=O)(=O)CC(=O)O	IC50 ~ 98000 nM	Poor binder
T52450	Matrix metalloproteinase-1	D0NP8A	UK-356618	Investigative	10370504	C34H43N3O4	557.7	CC1=C(C=CC(=C1)CCC[C@H](CC(=O)NO)C(=O)N[C@H](C(=O)N[C@H](C)C2=CC=CC=C2)C(C)(C)C)C3=CC=CC=C3	IC50 = 51000 nM	Poor binder
T52450	Matrix metalloproteinase-1	D0Q4TA	ARP100	Investigative	10044321	C17H20N2O5S	364.4	CC(C)ON(CC(=O)NO)S(=O)(=O)C1=CC=C(C=C1)C2=CC=CC=C2	IC50 ~ 50000 nM	Poor binder
T52450	Matrix metalloproteinase-1	D0T1FR	Cis-2-aminocyclohexylcarbamoylphosphonic acid	Investigative	44457233	C7H15N2O4P	222.18	C1CC[C@H]([C@H](C1)N)NC(=O)P(=O)(O)O	IC50 ~ 100000 nM	Poor binder
T52450	Matrix metalloproteinase-1	D0TL3N	5-(biphenyl-4-yl)-3-methoxypentanoic acid	Investigative	45482998	C18H20O3	284.3	COC(CCC1=CC=C(C=C1)C2=CC=CC=C2)CC(=O)O	IC50 ~ 98000 nM	Poor binder