TTD_Target_ID Target_Name TTD_Drug_ID Drug_Name Drug_Highest_Status Drug_PubchemID Molecular_Formula Molecular_Weight Canonical_SMILES Activity Binder_Type T52921 Nociceptin receptor B75LKV Hoo-Phe-Orn-Pro-hle-Pff-Phe-NH2 Investigative 73347136 C49H63FN10O9 955.1 CC(C)CC[C@@H](C(=O)N[C@@H](CC1=CC=C(C=C1)F)C(=O)N[C@H](CC2=CC=CC=C2)C(=O)N)NC(=O)[C@@H]3CCCN3C(=O)[C@H](CCCN)NC(=O)[C@H](CC4=CC=CC=C4)NC(=O)[C@@H]5CC(=O)NC(=O)N5 IC50 ~ 50000 nM Poor binder T52921 Nociceptin receptor B9VU1O 3-(1-Acenaphthen-1-yl-piperidin-4-yl)-7-chloro-1H-indole Investigative 44413385 C25H23ClN2 386.9 C1CN(CCC1C2=CNC3=C2C=CC=C3Cl)C4CC5=CC=CC6=C5C4=CC=C6 EC50 ~ 80000 nM Poor binder T52921 Nociceptin receptor BTW74D 5-Chloro-3-(1-(1,2-dihydroacenaphthylen-1-yl)piperidin-4-yl)-2-methyl-1H-indole Investigative 44413442 C26H25ClN2 400.9 CC1=C(C2=C(N1)C=CC(=C2)Cl)C3CCN(CC3)C4CC5=CC=CC6=C5C4=CC=C6 EC50 = 54600 nM Poor binder