TTD_Target_ID	Target_Name	TTD_Drug_ID	Drug_Name	Drug_Highest_Status	Drug_PubchemID	Molecular_Formula	Molecular_Weight	Canonical_SMILES	Activity	Binder_Type
T53389	TGF-beta receptor type I	B06BSO	COc1cc(cc(OC)c1OC)c2cc(cnc2N(C)C)c3ccc(cc3)N4CCNCC4	Investigative	118716168	C26H32N4O3	448.6	CN(C)C1=C(C=C(C=N1)C2=CC=C(C=C2)N3CCNCC3)C4=CC(=C(C(=C4)OC)OC)OC	IC50 = 115000 nM	Poor binder
T53389	TGF-beta receptor type I	B3GIH5	Coc1=CC=C(C=C1)C=1C(=NC=C(C1)C1=CC=C(C=C1)N1ccncc1)N	Investigative	118392571	C22H24N4O	360.5	COC1=CC=C(C=C1)C2=C(N=CC(=C2)C3=CC=C(C=C3)N4CCNCC4)N	IC50 = 95000 nM	Poor binder
T53389	TGF-beta receptor type I	B4JTY3	3-(4-Fluorophenyl)-2-(3-pyridyl)-6,7-dihydro-5H-pyrrolo[1,2-a]imidazole	Investigative	11780883	C17H14FN3	279.31	C1CC2=NC(=C(N2C1)C3=CC=C(C=C3)F)C4=CN=CC=C4	IC50 ~ 50000 nM	Poor binder
T53389	TGF-beta receptor type I	B4V0WB	COc1cc(cc(OC)c1OC)c2cc(cnc2OC)c3ccc(cc3)N4CCNCC4	Investigative	118392561	C25H29N3O4	435.5	COC1=CC(=CC(=C1OC)OC)C2=C(N=CC(=C2)C3=CC=C(C=C3)N4CCNCC4)OC	IC50 = 82000 nM	Poor binder
T53389	TGF-beta receptor type I	B9AWN8	4-[1-(6-Methylpyridin-2-yl)-5-quinoxalin-6-yltriazol-4-yl]butan-1-ol	Investigative	71552178	C20H20N6O	360.4	CC1=NC(=CC=C1)N2C(=C(N=N2)CCCCO)C3=CC4=NC=CN=C4C=C3	IC50 = 50800 nM	Poor binder
T53389	TGF-beta receptor type I	BC9Q4D	COc1cc(cc(OC)c1OC)c2cc(cnc2Cl)c3ccc(cc3)N4CCNCC4	Investigative	118716041	C24H26ClN3O3	439.9	COC1=CC(=CC(=C1OC)OC)C2=C(N=CC(=C2)C3=CC=C(C=C3)N4CCNCC4)Cl	IC50 = 99000 nM	Poor binder
T53389	TGF-beta receptor type I	BD30QK	5-(4-Fluorophenyl)-6-(pyridin-4-yl)hexahydroimidazo[2,1-b]thiazole	Investigative	45487453	C16H16FN3S	301.4	C1CSC2N1C(C(N2)C3=CC=NC=C3)C4=CC=C(C=C4)F	IC50 = 50000 nM	Poor binder
T53389	TGF-beta receptor type I	BJY07C	5-(4-Fluorophenyl)-6-(4-pyridyl)-2,3-dihydroimidazo[2,1-b]thiazole	Investigative	453216	C16H12FN3S	297.4	C1CSC2=NC(=C(N21)C3=CC=C(C=C3)F)C4=CC=NC=C4	IC50 ~ 50000 nM	Poor binder
T53389	TGF-beta receptor type I	BL47VE	Nc1ncc(cc1c2cccc3ncccc23)c4ccc(cc4)N5CCNCC5	Investigative	118716043	C24H23N5	381.5	C1CN(CCN1)C2=CC=C(C=C2)C3=CC(=C(N=C3)N)C4=C5C=CC=NC5=CC=C4	IC50 = 99000 nM	Poor binder
T53389	TGF-beta receptor type I	BQ5K6R	4-(3-Hydroxyphenyl)-1,2-dimethyl-5-(quinoxalin-6-yl)-1H-pyrazol-3(2H)-one	Investigative	16730509	C19H16N4O2	332.4	CN1C(=C(C(=O)N1C)C2=CC(=CC=C2)O)C3=CC4=NC=CN=C4C=C3	Ki = 53000 nM	Poor binder
T53389	TGF-beta receptor type I	BU5YK4	4-(3-Aminophenyl)-1,2-dimethyl-5-(quinoxalin-6-yl)-1H-pyrazol-3(2H)-one	Investigative	16730830	C19H17N5O	331.4	CN1C(=C(C(=O)N1C)C2=CC(=CC=C2)N)C3=CC4=NC=CN=C4C=C3	Ki = 130000 nM	Poor binder
T53389	TGF-beta receptor type I	BXSE80	4-(2-Hydroxyphenyl)-1,2-dimethyl-5-(quinoxalin-6-yl)-1H-pyrazol-3(2H)-one	Investigative	135798077	C19H16N4O2	332.4	CN1C(=C(C(=O)N1C)C2=CC=CC=C2O)C3=CC4=NC=CN=C4C=C3	Ki = 77000 nM	Poor binder