TTD_Target_ID	Target_Name	TTD_Drug_ID	Drug_Name	Drug_Highest_Status	Drug_PubchemID	Molecular_Formula	Molecular_Weight	Canonical_SMILES	Activity	Binder_Type
T53748	Plasmodium Enoyl-ACP reductase	B0EAH8	2-(Dimethylamino)ethyl 6-(5-benzylidene-4-oxo-2-thioxothiazolidin-3-yl)hexanoate	Investigative	5760122	C20H26N2O3S2	406.6	CN(C)CCOC(=O)CCCCCN1C(=O)/C(=C/C2=CC=CC=C2)/SC1=S	IC50 ~ 100000 nM	Poor binder
T53748	Plasmodium Enoyl-ACP reductase	B0VJ5O	6-(5-(4-Isopropylbenzylidene)-4-oxo-2-thioxothiazolidin-3-yl)hexanoic acid	Investigative	1560554	C19H23NO3S2	377.5	CC(C)C1=CC=C(C=C1)/C=C\\2/C(=O)N(C(=S)S2)CCCCCC(=O)O	IC50 ~ 100000 nM	Poor binder
T53748	Plasmodium Enoyl-ACP reductase	B17QCP	5-(4-(Dimethylamino)benzylidene)-3-(4-methoxyphenyl)-2-thioxothiazolidin-4-one	Investigative	1382811	C19H18N2O2S2	370.5	CN(C)C1=CC=C(C=C1)/C=C\\2/C(=O)N(C(=S)S2)C3=CC=C(C=C3)OC	IC50 ~ 100000 nM	Poor binder
T53748	Plasmodium Enoyl-ACP reductase	B2LMU0	2-(2,4-Dichlorophenoxy)-5-(2H-1,2,3,4-tetrazol-5-yl)phenol	Investigative	25023956	C13H8Cl2N4O2	323.13	C1=CC(=C(C=C1C2=NNN=N2)O)OC3=C(C=C(C=C3)Cl)Cl	IC50 ~ 100000 nM	Poor binder
T53748	Plasmodium Enoyl-ACP reductase	B3A7XD	3-(3-Chlorophenyl)-5-((5-(4-chlorophenyl)furan-2-yl)methylene)-2-thioxothiazolidin-4-one	Investigative	44423251	C20H11Cl2NO2S2	432.3	C1=CC(=CC(=C1)Cl)N2C(=O)/C(=C/C3=CC=C(O3)C4=CC=C(C=C4)Cl)/SC2=S	IC50 ~ 100000 nM	Poor binder
T53748	Plasmodium Enoyl-ACP reductase	B4BJX5	5-Chloro-2-(4-chloro-2-(pyrrolidin-1-ylmethyl)phenoxy)phenol	Investigative	44410138	C17H17Cl2NO2	338.2	C1CCN(C1)CC2=C(C=CC(=C2)Cl)OC3=C(C=C(C=C3)Cl)O	IC50 ~ 50000 nM	Poor binder
T53748	Plasmodium Enoyl-ACP reductase	B4HG0D	(5Z)-5-(3-Hydroxybenzylidene)-3-phenyl-2-thioxo-1,3-thiazolidin-4-one	Investigative	1718573	C16H11NO2S2	313.4	C1=CC=C(C=C1)N2C(=O)/C(=C/C3=CC(=CC=C3)O)/SC2=S	IC50 ~ 100000 nM	Poor binder
T53748	Plasmodium Enoyl-ACP reductase	B4O5ZD	Methylenebissantin	Investigative	56835122	C37H32O14	700.6	COC1=CC=C(C=C1)C2=C(C(=O)C3=C(O2)C(=C(C(=C3O)OC)O)CC4=C(C(=C(C5=C4OC(=C(C5=O)OC)C6=CC=C(C=C6)OC)O)OC)O)OC	IC50 = 91130 nM	Poor binder
T53748	Plasmodium Enoyl-ACP reductase	B5K9UM	5-Chloro-2-(4-chloro-2-((naphthalen-1-ylamino)methyl)phenoxy)phenol	Investigative	44410211	C23H17Cl2NO2	410.3	C1=CC=C2C(=C1)C=CC=C2NCC3=C(C=CC(=C3)Cl)OC4=C(C=C(C=C4)Cl)O	IC50 ~ 50000 nM	Poor binder
T53748	Plasmodium Enoyl-ACP reductase	B5P8KS	N-(5-Chloro-2-methoxyphenyl)-2-(5-chlorothiophen-2-yl)quinoline-4-carboxamide	Investigative	4984348	C21H14Cl2N2O2S	429.3	COC1=C(C=C(C=C1)Cl)NC(=O)C2=CC(=NC3=CC=CC=C32)C4=CC=C(S4)Cl	IC50 = 60000 nM	Poor binder
T53748	Plasmodium Enoyl-ACP reductase	B6TE5H	5-(4-Isopropylbenzylidene)-3-(4-methoxyphenyl)-2-thioxothiazolidin-4-one	Investigative	1232811	C20H19NO2S2	369.5	CC(C)C1=CC=C(C=C1)/C=C\\2/C(=O)N(C(=S)S2)C3=CC=C(C=C3)OC	IC50 ~ 100000 nM	Poor binder
T53748	Plasmodium Enoyl-ACP reductase	B7JCH1	2-(5-Chlorothiophen-2-yl)-N-(2-(3,4-dihydroquinolin-1(2H)-yl)ethyl)quinoline-4-carboxamide	Investigative	22427741	C25H22ClN3OS	448	C1CC2=CC=CC=C2N(C1)CCNC(=O)C3=CC(=NC4=CC=CC=C43)C5=CC=C(S5)Cl	IC50 = 60000 nM	Poor binder
T53748	Plasmodium Enoyl-ACP reductase	B8TNY1	3-[4-(Diethylamino)phenyl]-5-(4-methoxybenzylidene)-2-thioxo-1,3-thiazolidin-4-one	Investigative	1590532	C21H22N2O2S2	398.5	CCN(CC)C1=CC=C(C=C1)N2C(=O)/C(=C/C3=CC=C(C=C3)OC)/SC2=S	IC50 ~ 50000 nM	Poor binder
T53748	Plasmodium Enoyl-ACP reductase	B93LCA	Methyl 6-(5-(4-chlorobenzylidene)-4-oxo-2-thioxothiazolidin-3-yl)hexanoate	Investigative	6000620	C17H18ClNO3S2	383.9	COC(=O)CCCCCN1C(=O)/C(=C/C2=CC=C(C=C2)Cl)/SC1=S	IC50 ~ 100000 nM	Poor binder
T53748	Plasmodium Enoyl-ACP reductase	BA8M5R	N-(4-Chlorobenzyl)-2-(4-chlorobenzylthio)quinazolin-4-amine	Investigative	4391438	C22H17Cl2N3S	426.4	C1=CC=C2C(=C1)C(=NC(=N2)SCC3=CC=C(C=C3)Cl)NCC4=CC=C(C=C4)Cl	IC50 = 52000 nM	Poor binder
T53748	Plasmodium Enoyl-ACP reductase	BA8Q4X	5-((5-(3,4-Dichlorophenyl)furan-2-yl)methylene)-3-methyl-2-thioxothiazolidin-4-one	Investigative	16427167	C15H9Cl2NO2S2	370.3	CN1C(=O)/C(=C/C2=CC=C(O2)C3=CC(=C(C=C3)Cl)Cl)/SC1=S	IC50 ~ 100000 nM	Poor binder
T53748	Plasmodium Enoyl-ACP reductase	BBQM38	6-(5-((1H-Indol-3-yl)methylene)-4-oxo-2-thioxothiazolidin-3-yl)hexanoic acid	Investigative	135993357	C18H18N2O3S2	374.5	C1=CC=C2C(=C1)/C(=C\\C3=C(N(C(=S)S3)CCCCCC(=O)O)O)/C=N2	IC50 = 100000 nM	Poor binder
T53748	Plasmodium Enoyl-ACP reductase	BD0GX8	6-(5-(4-(Benzyloxy)-3-methylbenzylidene)-4-oxo-2-thioxothiazolidin-3-yl)hexanoic acid	Investigative	44423245	C24H25NO4S2	455.6	CC1=C(C=CC(=C1)/C=C\\2/C(=O)N(C(=S)S2)CCCCCC(=O)O)OCC3=CC=CC=C3	IC50 ~ 100000 nM	Poor binder
T53748	Plasmodium Enoyl-ACP reductase	BDX5P0	Methyl 6-(5-(4-ethylbenzylidene)-4-oxo-2-thioxothiazolidin-3-yl)hexanoate	Investigative	1561390	C19H23NO3S2	377.5	CCC1=CC=C(C=C1)/C=C\\2/C(=O)N(C(=S)S2)CCCCCC(=O)OC	IC50 ~ 100000 nM	Poor binder
T53748	Plasmodium Enoyl-ACP reductase	BG9H5Q	5-(4-Methoxybenzylidene)-3-(4-methoxyphenyl)-2-thioxothiazolidin-4-one	Investigative	1382809	C18H15NO3S2	357.5	COC1=CC=C(C=C1)/C=C\\2/C(=O)N(C(=S)S2)C3=CC=C(C=C3)OC	IC50 ~ 100000 nM	Poor binder
T53748	Plasmodium Enoyl-ACP reductase	BGD8U4	3-[(4-Tert-butylphenyl)methylsulfanyl]-2-[(6-chloropyridazin-3-yl)amino]phthalazin-3-ium-1-one	Investigative	44423264	C23H23ClN5OS+	453	CC(C)(C)C1=CC=C(C=C1)CS[N+]2=CC3=CC=CC=C3C(=O)N2NC4=NN=C(C=C4)Cl	IC50 = 50000 nM	Poor binder
T53748	Plasmodium Enoyl-ACP reductase	BHZ32L	5-Chloro-2-(4-chloro-2-(piperidin-1-ylmethyl)phenoxy)phenol	Investigative	44410233	C18H19Cl2NO2	352.3	C1CCN(CC1)CC2=C(C=CC(=C2)Cl)OC3=C(C=C(C=C3)Cl)O	IC50 ~ 50000 nM	Poor binder
T53748	Plasmodium Enoyl-ACP reductase	BIK15G	3-[5-(2,4-Dichloro-benzylidene)-4-oxo-2-thioxo-thiazolidin-3-yl]-propionic acid	Investigative	2248987	C17H18Cl2N2O3S2	433.4	CN(C)CCOC(=O)CCN1C(=O)/C(=C/C2=C(C=C(C=C2)Cl)Cl)/SC1=S	IC50 ~ 100000 nM	Poor binder
T53748	Plasmodium Enoyl-ACP reductase	BJF89I	2-(2-(Aminomethyl)-4-chlorophenoxy)-5-chlorophenol	Investigative	44410129	C13H11Cl2NO2	284.13	C1=CC(=C(C=C1Cl)CN)OC2=C(C=C(C=C2)Cl)O	IC50 ~ 50000 nM	Poor binder
T53748	Plasmodium Enoyl-ACP reductase	BJS71Z	3-(3-Fluorophenyl)-5-(furan-2-ylmethylene)-2-thioxothiazolidin-4-one	Investigative	6973832	C14H8FNO2S2	305.4	C1=CC(=CC(=C1)F)N2C(=O)/C(=C/C3=CC=CO3)/SC2=S	IC50 ~ 100000 nM	Poor binder
T53748	Plasmodium Enoyl-ACP reductase	BKW93H	Methyl 6-(5-(3-hydroxybenzylidene)-4-oxo-2-thioxothiazolidin-3-yl)hexanoate	Investigative	1561418	C17H19NO4S2	365.5	COC(=O)CCCCCN1C(=O)/C(=C/C2=CC(=CC=C2)O)/SC1=S	IC50 ~ 100000 nM	Poor binder
T53748	Plasmodium Enoyl-ACP reductase	BMQL96	2-(2-(Aminomethyl)phenoxy)-5-chlorophenol	Investigative	44410252	C13H12ClNO2	249.69	C1=CC=C(C(=C1)CN)OC2=C(C=C(C=C2)Cl)O	IC50 ~ 50000 nM	Poor binder
T53748	Plasmodium Enoyl-ACP reductase	BN18UE	(5Z)-3-(4-Fluorophenyl)-5-(3-hydroxybenzylidene)-2-thioxo-1,3-thiazolidin-4-one	Investigative	1202264	C16H10FNO2S2	331.4	C1=CC(=CC(=C1)O)/C=C\\2/C(=O)N(C(=S)S2)C3=CC=C(C=C3)F	IC50 ~ 100000 nM	Poor binder
T53748	Plasmodium Enoyl-ACP reductase	BN75VD	5-(3,5-Dichloro-4-hydroxybenzylidene)-3-ethyl-2-thioxothiazolidin-4-one	Investigative	1559978	C12H9Cl2NO2S2	334.2	CCN1C(=O)/C(=C/C2=CC(=C(C(=C2)Cl)O)Cl)/SC1=S	IC50 ~ 100000 nM	Poor binder
T53748	Plasmodium Enoyl-ACP reductase	BNU28E	2-(3-Chlorophenylthio)-N-(1,2,3,4-tetrahydronaphthalen-1-yl)quinoline-4-carboxamide	Investigative	4053176	C26H21ClN2OS	445	C1CC(C2=CC=CC=C2C1)NC(=O)C3=CC(=NC4=CC=CC=C43)SC5=CC(=CC=C5)Cl	IC50 = 50000 nM	Poor binder
T53748	Plasmodium Enoyl-ACP reductase	BO1DZ5	(5Z)-5-Benzylidene-3-(4-methoxyphenyl)-2-thioxo-1,3-thiazolidin-4-one	Investigative	1556190	C17H13NO2S2	327.4	COC1=CC=C(C=C1)N2C(=O)/C(=C/C3=CC=CC=C3)/SC2=S	IC50 ~ 100000 nM	Poor binder
T53748	Plasmodium Enoyl-ACP reductase	BO24YA	4-((5Z)-5-{[3-(4-Chlorophenyl)-1-phenyl-1H-pyrazol-4-yl]methylene}-4-oxo-2-thioxo-1,3-thiazolidin-3-yl)butanoic acid	Investigative	1526752	C23H18ClN3O3S2	484	C1=CC=C(C=C1)N2C=C(C(=N2)C3=CC=C(C=C3)Cl)/C=C\\4/C(=O)N(C(=S)S4)CCCC(=O)O	IC50 = 50000 nM	Poor binder
T53748	Plasmodium Enoyl-ACP reductase	BO2I5F	N-(2-(4-Chloro-2-methoxyphenoxy)benzyl)(4-chlorophenyl)methanamine	Investigative	44410295	C21H19Cl2NO2	388.3	COC1=C(C=CC(=C1)Cl)OC2=CC=CC=C2CNCC3=CC=C(C=C3)Cl	IC50 ~ 50000 nM	Poor binder
T53748	Plasmodium Enoyl-ACP reductase	BOG3D1	4-(2,4-Dichlorophenoxy)-3-hydroxybenzoic acid	Investigative	23656593	C13H8Cl2O4	299.1	C1=CC(=C(C=C1C(=O)O)O)OC2=C(C=C(C=C2)Cl)Cl	IC50 ~ 100000 nM	Poor binder
T53748	Plasmodium Enoyl-ACP reductase	BP12WR	N-(5-Chloro-2-hydroxyphenyl)-5-(4-methoxyphenyl)isoxazole-3-carboxamide	Investigative	17252838	C17H13ClN2O4	344.7	COC1=CC=C(C=C1)C2=CC(=NO2)C(=O)NC3=C(C=CC(=C3)Cl)O	IC50 = 55000 nM	Poor binder
T53748	Plasmodium Enoyl-ACP reductase	BR17IS	2-(2-((4-Benzhydrylpiperazin-1-yl)methyl)-4-chlorophenoxy)-5-chlorophenol	Investigative	44410215	C30H28Cl2N2O2	519.5	C1CN(CCN1CC2=C(C=CC(=C2)Cl)OC3=C(C=C(C=C3)Cl)O)C(C4=CC=CC=C4)C5=CC=CC=C5	IC50 ~ 50000 nM	Poor binder
T53748	Plasmodium Enoyl-ACP reductase	BR61XP	5-(Anthracen-10-ylmethylene)-3-(4-methoxyphenyl)-2-thioxothiazolidin-4-one	Investigative	5757816	C25H17NO2S2	427.5	COC1=CC=C(C=C1)N2C(=O)/C(=C/C3=C4C=CC=CC4=CC5=CC=CC=C53)/SC2=S	IC50 ~ 50000 nM	Poor binder
T53748	Plasmodium Enoyl-ACP reductase	BS15AK	N-(5-Chloro-2-hydroxyphenyl)-5-(4-chlorophenyl)isoxazole-3-carboxamide	Investigative	17252735	C16H10Cl2N2O3	349.2	C1=CC(=CC=C1C2=CC(=NO2)C(=O)NC3=C(C=CC(=C3)Cl)O)Cl	IC50 = 75000 nM	Poor binder
T53748	Plasmodium Enoyl-ACP reductase	BT4BC9	3-(3-Chlorophenyl)-5-((5-(3-chlorophenyl)furan-2-yl)methylene)-2-thioxothiazolidin-4-one	Investigative	1726124	C20H11Cl2NO2S2	432.3	C1=CC(=CC(=C1)Cl)C2=CC=C(O2)/C=C\\3/C(=O)N(C(=S)S3)C4=CC(=CC=C4)Cl	IC50 ~ 100000 nM	Poor binder
T53748	Plasmodium Enoyl-ACP reductase	BX6RJ2	2-(2-(4-Chlorostyryl)-1H-benzo[d]imidazol-5-yl)-4,5,6,7-tetrachloroisoindoline-1,3-dione	Investigative	44423265	C23H10Cl5N3O2	537.6	C1=CC(=CC=C1/C=C/C2=NC3=C(N2)C=C(C=C3)N4C(=O)C5=C(C4=O)C(=C(C(=C5Cl)Cl)Cl)Cl)Cl	IC50 = 70000 nM	Poor binder
T53748	Plasmodium Enoyl-ACP reductase	BXV2T0	(5Z)-5-[4-(Diethylamino)-2-hydroxybenzylidene]-3-ethyl-2-thioxo-1,3-thiazolidin-4-one	Investigative	6523040	C16H20N2O2S2	336.5	CCN1C(=O)/C(=C/C2=C(C=C(C=C2)N(CC)CC)O)/SC1=S	IC50 ~ 100000 nM	Poor binder
T53748	Plasmodium Enoyl-ACP reductase	BYG46W	6-{(5Z)-5-[3-Methoxy-4-(pentyloxy)benzylidene]-4-oxo-2-thioxo-1,3-thiazolidin-3-yl}hexanoic acid	Investigative	5710617	C22H29NO5S2	451.6	CCCCCOC1=C(C=C(C=C1)/C=C\\2/C(=O)N(C(=S)S2)CCCCCC(=O)O)OC	IC50 ~ 100000 nM	Poor binder
T53748	Plasmodium Enoyl-ACP reductase	BZ24VT	N-(5-Ethyl-1,3,4-thiadiazol-2-yl)-4-(4,5,6,7-tetrachloro-1,3-dioxoisoindolin-2-yl)benzenesulfonamide	Investigative	3637765	C18H10Cl4N4O4S2	552.2	CCC1=NN=C(S1)NS(=O)(=O)C2=CC=C(C=C2)N3C(=O)C4=C(C3=O)C(=C(C(=C4Cl)Cl)Cl)Cl	IC50 = 90000 nM	Poor binder
T53748	Plasmodium Enoyl-ACP reductase	D00RIX	APIGENIN	Investigative	5280443	C15H10O5	270.24	C1=CC(=CC=C1C2=CC(=O)C3=C(C=C(C=C3O2)O)O)O	IC50 = 50000 nM	Poor binder