TTD_Target_ID Target_Name TTD_Drug_ID Drug_Name Drug_Highest_Status Drug_PubchemID Molecular_Formula Molecular_Weight Canonical_SMILES Activity Binder_Type T55689 Hormone sensitive lipase B1G0BA 5-Methylsulfanyl-3-(4-trifluoromethoxy-phenyl)-[1,2,4]triazole-1-carboxylic acid dimethylamide Investigative 11210161 C13H13F3N4O2S 346.33 CN(C)C(=O)N1C(=NC(=N1)C2=CC=C(C=C2)OC(F)(F)F)SC IC50 = 100000 nM Poor binder T55689 Hormone sensitive lipase B3TS9A 5-Methylsulfanyl-3-((E)-styryl)-[1,2,4]triazole-1-carboxylic acid dimethylamide Investigative 11243200 C14H16N4OS 288.37 CN(C)C(=O)N1C(=NC(=N1)/C=C/C2=CC=CC=C2)SC IC50 ~ 50000 nM Poor binder T55689 Hormone sensitive lipase B4XL9N (3-(4-Chlorophenyl)-5-(hexylthio)-1H-1,2,4-triazol-1-yl)(morpholino)methanone Investigative 11235216 C19H25ClN4O2S 408.9 CCCCCCSC1=NC(=NN1C(=O)N2CCOCC2)C3=CC=C(C=C3)Cl IC50 ~ 50000 nM Poor binder T55689 Hormone sensitive lipase BF5M8E 5-Hexylsulfanyl-3-p-tolyl-[1,2,4]triazole-1-carboxylic acid dimethylamide Investigative 11772375 C18H26N4OS 346.5 CCCCCCSC1=NC(=NN1C(=O)N(C)C)C2=CC=C(C=C2)C IC50 ~ 50000 nM Poor binder T55689 Hormone sensitive lipase BQW9O8 [3-(4-Chloro-phenyl)-5-hexylsulfanyl-[1,2,4]triazol-1-yl]-piperidin-1-yl-methanone Investigative 11304331 C20H27ClN4OS 407 CCCCCCSC1=NC(=NN1C(=O)N2CCCCC2)C3=CC=C(C=C3)Cl IC50 ~ 50000 nM Poor binder T55689 Hormone sensitive lipase BU64JQ 8a-Tert-Butoxymethyl-6-furan-2-yl-1,4-dioxo-2-(4-phenyl-butyl)-octahydro-pyrrolo[1,2-a]pyrazine-7-carboxylic acid phenyl ester Investigative 44269110 C33H38N2O6 558.7 CC(C)(C)OCC12CC(C(N1C(=O)CN(C2=O)CCCCC3=CC=CC=C3)C4=CC=CO4)C(=O)OC5=CC=CC=C5 IC50 = 67000 nM Poor binder T55689 Hormone sensitive lipase BVP45S Dimethyl-carbamic Acid 4-(3,5-dichloro pyridin-2-yloxy)-phenyl Ester Investigative 23635398 C14H12Cl2N2O3 327.2 CN(C)C(=O)OC1=CC=C(C=C1)OC2=C(C=C(C=N2)Cl)Cl IC50 ~ 50000 nM Poor binder T55689 Hormone sensitive lipase BY7MS4 8a-Benzyloxymethyl-2-(2-cyclohex-1-enyl-ethyl)-6-furan-2-yl-1,4-dioxo-octahydro-pyrrolo[1,2-a]pyrazine-7-carboxylic acid ethyl ester Investigative 44269096 C30H36N2O6 520.6 CCOC(=O)C1CC2(C(=O)N(CC(=O)N2C1C3=CC=CO3)CCC4=CCCCC4)COCC5=CC=CC=C5 IC50 ~ 100000 nM Poor binder