TTD_Target_ID	Target_Name	TTD_Drug_ID	Drug_Name	Drug_Highest_Status	Drug_PubchemID	Molecular_Formula	Molecular_Weight	Canonical_SMILES	Activity	Binder_Type
T56143	Kynurenic acid receptor	D0J1VY	Entacapone	Approved	5281081	C14H15N3O5	305.29	CCN(CC)C(=O)/C(=C/C1=CC(=C(C(=C1)O)O)[N+](=O)[O-])/C#N	EC50 = 65600 nM	Poor binder
T56143	Kynurenic acid receptor	B0KE1H	4,6-Dinitro-O-cresol	Investigative	10800	C7H6N2O5	198.13	CC1=CC(=CC(=C1O)[N+](=O)[O-])[N+](=O)[O-]	EC50 = 81100 nM	Poor binder
T56143	Kynurenic acid receptor	B39BCF	2,6-Dinitrophenol	Investigative	11312	C6H4N2O5	184.11	C1=CC(=C(C(=C1)[N+](=O)[O-])O)[N+](=O)[O-]	EC50 = 76000 nM	Poor binder
T56143	Kynurenic acid receptor	B3XVK8	2,3-Dinitrophenol	Investigative	6191	C6H4N2O5	184.11	C1=CC(=C(C(=C1)O)[N+](=O)[O-])[N+](=O)[O-]	EC50 = 58500 nM	Poor binder
T56143	Kynurenic acid receptor	B4UFV8	5,6-Dihydroxy-3-pyridin-3-yl-1H-indole-2-carboxylic acid	Investigative	70689183	C14H10N2O4	270.24	C1=CC(=CN=C1)C2=C(NC3=CC(=C(C=C32)O)O)C(=O)O	EC50 = 84000 nM	Poor binder
T56143	Kynurenic acid receptor	B4W2HL	Dithieno[3,2-b:2',3'-d]thiophene-2-carboxylic acid, 5-methyl-	Investigative	16103465	C10H6O2S3	254.4	CC1=CSC2=C1SC3=C2SC(=C3)C(=O)O	EC50 ~ 50000 nM	Poor binder
T56143	Kynurenic acid receptor	B5I3NA	3-Cyclopropyl-6-methyl-4H-thieno[3,2-b]pyrrole-5-carboxylic acid	Investigative	70681839	C11H11NO2S	221.28	CC1=C(NC2=C1SC=C2C3CC3)C(=O)O	EC50 = 119000 nM	Poor binder
T56143	Kynurenic acid receptor	B68CGN	5,6-Dihydroxy-1-methyl-1H-indole-2-carboxylic acid	Investigative	15774807	C10H9NO4	207.18	CN1C2=CC(=C(C=C2C=C1C(=O)O)O)O	EC50 = 64200 nM	Poor binder
T56143	Kynurenic acid receptor	B7RNM5	6-Methyl-3-(1H-pyrazol-4-yl)thieno[3,2-b]thiophene-5-carboxylic acid	Investigative	70686065	C11H8N2O2S2	264.3	CC1=C(SC2=C1SC=C2C3=CNN=C3)C(=O)O	EC50 = 52500 nM	Poor binder
T56143	Kynurenic acid receptor	B9NE7Q	alpha-Cyano-4-hydroxycinnamic acid	Investigative	5328791	C10H7NO3	189.17	C1=CC(=CC=C1/C=C(\\C#N)/C(=O)O)O	EC50 = 70700 nM	Poor binder
T56143	Kynurenic acid receptor	B9Z0JN	3-Bromo-6-methyl-4H-thieno[3,2-b]pyrrole-5-carboxylic acid	Investigative	70692387	C8H6BrNO2S	260.11	CC1=C(NC2=C1SC=C2Br)C(=O)O	EC50 = 113000 nM	Poor binder
T56143	Kynurenic acid receptor	BAOX17	3-Ethynyl-6-methylthieno[3,2-b]thiophene-5-carboxylic acid	Investigative	70694439	C10H6O2S2	222.3	CC1=C(SC2=C1SC=C2C#C)C(=O)O	EC50 = 54800 nM	Poor binder
T56143	Kynurenic acid receptor	BAWU69	3-Bromo-5,6-dihydroxy-1H-indole-2-carboxylic acid	Investigative	70682865	C9H6BrNO4	272.05	C1=C2C(=CC(=C1O)O)NC(=C2Br)C(=O)O	EC50 = 166000 nM	Poor binder
T56143	Kynurenic acid receptor	BB0XP3	2-(3-Cyano-4,5,5-trimethylfuran-2-ylidene)propanedinitrile	Investigative	9990345	C11H9N3O	199.21	CC1=C(C(=C(C#N)C#N)OC1(C)C)C#N	EC50 ~ 50000 nM	Poor binder
T56143	Kynurenic acid receptor	BBK8I4	3-(3-Carboxyphenyl)-5,6-dihydroxy-1H-indole-2-carboxylic acid	Investigative	70689184	C16H11NO6	313.26	C1=CC(=CC(=C1)C(=O)O)C2=C(NC3=CC(=C(C=C32)O)O)C(=O)O	EC50 = 75700 nM	Poor binder
T56143	Kynurenic acid receptor	BEW01C	Laccaic acid A	Investigative	5491415	C26H19NO12	537.4	CC(=O)NCCC1=CC(=C(C=C1)O)C2=C(C3=C(C(=C2O)O)C(=O)C4=CC(=C(C(=C4C3=O)C(=O)O)C(=O)O)O)O	EC50 = 51500 nM	Poor binder
T56143	Kynurenic acid receptor	BF6S4X	5,6-Dihydroxy-3-thiophen-3-yl-1H-indole-2-carboxylic acid	Investigative	70682869	C13H9NO4S	275.28	C1=CSC=C1C2=C(NC3=CC(=C(C=C32)O)O)C(=O)O	EC50 = 61200 nM	Poor binder
T56143	Kynurenic acid receptor	BFUN98	3-Bromo-6-octylthieno[3,2-b]thiophene-5-carboxylic acid	Investigative	53258793	C15H19BrO2S2	375.3	CCCCCCCCC1=C(SC2=C1SC=C2Br)C(=O)O	EC50 ~ 50000 nM	Poor binder
T56143	Kynurenic acid receptor	BFVA93	(3,4-Dihydroxy-5-nitrophenyl)(2-fluorophenyl)methanone	Investigative	3495594	C13H8FNO5	277.2	C1=CC=C(C(=C1)C(=O)C2=CC(=C(C(=C2)O)O)[N+](=O)[O-])F	EC50 = 54400 nM	Poor binder
T56143	Kynurenic acid receptor	BGPM30	3-Methyl-DHTCA	Investigative	70684936	C10H8O4S	224.23	CC1=C(SC2=CC(=C(C=C12)O)O)C(=O)O	EC50 = 90600 nM	Poor binder
T56143	Kynurenic acid receptor	BJB1H0	4-Bromo-2-(1H-tetrazol-5-yl)aniline	Investigative	10868388	C7H6BrN5	240.06	C1=CC(=C(C=C1Br)C2=NNN=N2)N	IC50 = 75340 nM	Poor binder
T56143	Kynurenic acid receptor	BKIB07	3,4-Dinitrophenol	Investigative	11348	C6H4N2O5	184.11	C1=CC(=C(C=C1O)[N+](=O)[O-])[N+](=O)[O-]	EC50 = 112000 nM	Poor binder
T56143	Kynurenic acid receptor	BLGN63	5,6-Dihydroxy-3-methyl-1-benzofuran-2-carboxylic acid	Investigative	45093111	C10H8O5	208.17	CC1=C(OC2=CC(=C(C=C12)O)O)C(=O)O	EC50 = 133000 nM	Poor binder
T56143	Kynurenic acid receptor	BLOR47	3-Bromo-4,6-dimethylthieno[3,2-b]pyrrole-5-carboxylic acid	Investigative	70690213	C9H8BrNO2S	274.14	CC1=C(N(C2=C1SC=C2Br)C)C(=O)O	EC50 = 87500 nM	Poor binder
T56143	Kynurenic acid receptor	BN8A2M	3-Cyclopropyl-6-methylthieno[3,2-b]thiophene-5-carboxylic acid	Investigative	70683939	C11H10O2S2	238.3	CC1=C(SC2=C1SC=C2C3CC3)C(=O)O	EC50 = 52400 nM	Poor binder
T56143	Kynurenic acid receptor	BO32RQ	3-Hexylthieno[3,2-b]thiophene-2-carboxylic acid	Investigative	16103482	C13H16O2S2	268.4	CCCCCCC1=C(SC2=C1SC=C2)C(=O)O	EC50 ~ 50000 nM	Poor binder
T56143	Kynurenic acid receptor	BQN58S	Thieno[3,2-b]thiophene-2-carboxylic acid	Investigative	660319	C7H4O2S2	184.2	C1=CSC2=C1SC(=C2)C(=O)O	IC50 = 57000 nM	Poor binder
T56143	Kynurenic acid receptor	BQP2S0	3-(3,5-Difluorophenyl)-5,6-dihydroxy-1H-indole-2-carboxylic acid	Investigative	70687104	C15H9F2NO4	305.23	C1=C(C=C(C=C1F)F)C2=C(NC3=CC(=C(C=C32)O)O)C(=O)O	EC50 = 109000 nM	Poor binder
T56143	Kynurenic acid receptor	BRS78Q	2-[3-Cyano-5-(2,4-difluorophenyl)-4,5-dimethylfuran-2-ylidene]propanedinitrile	Investigative	21337671	C16H9F2N3O	297.26	CC1=C(C(=C(C#N)C#N)OC1(C)C2=C(C=C(C=C2)F)F)C#N	EC50 = 53900 nM	Poor binder
T56143	Kynurenic acid receptor	BSWD24	6-Hexyl-thieno[3,2-b]thiophene-2-carboxylic acid	Investigative	53258899	C13H16O2S2	268.4	CCCCCCC1=CSC2=C1SC(=C2)C(=O)O	EC50 ~ 50000 nM	Poor binder
T56143	Kynurenic acid receptor	BTCB19	2-(3-Cyano-4-methyl-5-phenyl-5-(trifluoromethyl)furan-2(5H)-ylidene)malononitrile	Investigative	11674067	C16H8F3N3O	315.25	CC1=C(C(=C(C#N)C#N)OC1(C2=CC=CC=C2)C(F)(F)F)C#N	EC50 ~ 50000 nM	Poor binder
T56143	Kynurenic acid receptor	BUOL64	[3-Cyano-4-methyl-1-oxaspiro[4.5]deca-3-ene-2-ylidene]malononitrile	Investigative	21337669	C14H13N3O	239.27	CC1=C(C(=C(C#N)C#N)OC12CCCCC2)C#N	EC50 ~ 50000 nM	Poor binder
T56143	Kynurenic acid receptor	BYS9P4	2,5-Dinitrophenol	Investigative	9492	C6H4N2O5	184.11	C1=CC(=C(C=C1[N+](=O)[O-])O)[N+](=O)[O-]	EC50 = 52600 nM	Poor binder
T56143	Kynurenic acid receptor	BZ4S3I	1-Ethyl-5,6-dihydroxyindole-2-carboxylic acid	Investigative	70697498	C11H11NO4	221.21	CCN1C2=CC(=C(C=C2C=C1C(=O)O)O)O	EC50 = 77100 nM	Poor binder
T56143	Kynurenic acid receptor	D01SHB	TRANSTORINE	Investigative	3845	C10H7NO3	189.17	C1=CC=C2C(=C1)C(=O)C=C(N2)C(=O)O	Ki = 137000 nM	Poor binder
T56143	Kynurenic acid receptor	D09AYR	3,5-Dinitrocatechol	Investigative	3870203	C6H4N2O6	200.11	C1=C(C=C(C(=C1[N+](=O)[O-])O)O)[N+](=O)[O-]	EC50 = 123000 nM	Poor binder
T56143	Kynurenic acid receptor	D0H3NS	2-oxo-2H-chromene-3-carboxylic acid	Investigative	10752	C10H6O4	190.15	C1=CC=C2C(=C1)C=C(C(=O)O2)C(=O)O	EC50 = 92260 nM	Poor binder