TTD_Target_ID	Target_Name	TTD_Drug_ID	Drug_Name	Drug_Highest_Status	Drug_PubchemID	Molecular_Formula	Molecular_Weight	Canonical_SMILES	Activity	Binder_Type
T58178	Glutamate receptor ionotropic kainate 2	D0B0NQ	LY293558	Phase 2	127894	C13H21N5O2	279.34	C1C[C@H]2CN[C@@H](C[C@H]2C[C@H]1CCC3=NNN=N3)C(=O)O	Ki ~ 100000 nM	Poor binder
T58178	Glutamate receptor ionotropic kainate 2	D02VKC	NBQX	Phase 1	3272524	C12H8N4O6S	336.28	C1=CC2=C3C(=CC(=C2C(=C1)S(=O)(=O)N)[N+](=O)[O-])NC(=O)C(=O)N3	Ki ~ 100000 nM	Poor binder
T58178	Glutamate receptor ionotropic kainate 2	D04XMJ	LY525327	Terminated	11249042	C23H34N6O2	426.6	CCC(CC)COC(=O)[C@@H]1C[C@H]2C[C@H](CC[C@H]2CN1)NC3=CC=CC=C3C4=NNN=N4	Ki ~ 100000 nM	Poor binder
T58178	Glutamate receptor ionotropic kainate 2	B0Y9JQ	(S)-2-Amino-4-pentylidene-pentanedioicacid	Investigative	44296576	C10H17NO4	215.25	CCCC/C=C(/C[C@@H](C(=O)O)N)\\C(=O)O	Ki = 125000 nM	Poor binder
T58178	Glutamate receptor ionotropic kainate 2	B14PDH	(3S,4As,6S,8aR)-6-[2-(1H-Tetrazol-5-yl)-phenoxy]-decahydro-isoquinoline-3-carboxylic acid	Investigative	11153198	C17H21N5O3	343.4	C1C[C@H]2CN[C@@H](C[C@H]2C[C@H]1OC3=CC=CC=C3C4=NNN=N4)C(=O)O	Ki ~ 100000 nM	Poor binder
T58178	Glutamate receptor ionotropic kainate 2	B1HEP0	2-Amino-4-but-2-enyl-pentanedioic acid(LY339180)	Investigative	10774436	C9H15NO4	201.22	C/C=C/C[C@H](C[C@@H](C(=O)O)N)C(=O)O	EC50 = 58300 nM	Poor binder
T58178	Glutamate receptor ionotropic kainate 2	B32JIQ	4-[(E)-2,2-Dimethylcyclopentylidene]-L-glutamic acid	Investigative	44296493	C12H19NO4	241.28	CC\\1(CCC/C1=C(/C[C@@H](C(=O)O)N)\\C(=O)O)C	Ki ~ 100000 nM	Poor binder
T58178	Glutamate receptor ionotropic kainate 2	B3IOT8	4-[(E)-4-Chlorobenzylidene]-L-glutamic acid	Investigative	44296615	C12H12ClNO4	269.68	C1=CC(=CC=C1/C=C(\\C[C@@H](C(=O)O)N)/C(=O)O)Cl	Ki = 193000 nM	Poor binder
T58178	Glutamate receptor ionotropic kainate 2	B3Z4CI	(RS)-2-amino-3-[3-hydroxy-5-(2-propyl-2H-5-tetrazolyl)-4-isoxazolyl]propionic acid	Investigative	11219775	C10H14N6O4	282.26	CCCN1N=C(N=N1)C2=C(C(=O)NO2)CC(C(=O)O)N	Ki ~ 100000 nM	Poor binder
T58178	Glutamate receptor ionotropic kainate 2	B4IUH2	(S)-2-Amino-4-cyclopentylidene-pentanedioic acid	Investigative	10219992	C10H15NO4	213.23	C1CCC(=C(C[C@@H](C(=O)O)N)C(=O)O)C1	Ki ~ 100000 nM	Poor binder
T58178	Glutamate receptor ionotropic kainate 2	B5AV7G	4-[(E)-2,2-Dimethylpropylidene]-L-glutamic acid	Investigative	10330885	C10H17NO4	215.25	CC(C)(C)/C=C(\\C[C@@H](C(=O)O)N)/C(=O)O	Ki ~ 100000 nM	Poor binder
T58178	Glutamate receptor ionotropic kainate 2	B6DUC2	(S)-2-Amino-4-butylidene-pentanedioic acid	Investigative	44296800	C9H15NO4	201.22	CCC/C=C(/C[C@@H](C(=O)O)N)\\C(=O)O	Ki = 57200 nM	Poor binder
T58178	Glutamate receptor ionotropic kainate 2	B6N2UW	4-Cyclobutylidene-L-glutamic acid	Investigative	44296494	C9H13NO4	199.2	C1CC(=C(C[C@@H](C(=O)O)N)C(=O)O)C1	Ki ~ 100000 nM	Poor binder
T58178	Glutamate receptor ionotropic kainate 2	B6Q4GU	(3S,4As,6S,8aR)-6-[2-(1H-Tetrazol-5-yl)-phenoxy]-decahydro-isoquinoline-3-carboxylic acid isobutyl ester	Investigative	11154806	C21H29N5O3	399.5	CC(C)COC(=O)[C@@H]1C[C@H]2C[C@H](CC[C@H]2CN1)OC3=CC=CC=C3C4=NNN=N4	Ki ~ 100000 nM	Poor binder
T58178	Glutamate receptor ionotropic kainate 2	B7OQ8J	(2s)-2-Amino-3-(4-Hydroxy-1,2,5-Thiadiazol-3-Yl)propanoic Acid	Investigative	10352480	C5H7N3O3S	189.2	C(C1=NSNC1=O)[C@@H](C(=O)O)N	Ki ~ 100000 nM	Poor binder
T58178	Glutamate receptor ionotropic kainate 2	B7VLA8	2-Amino-4-hex-2-ynyl-pentanedioic acid	Investigative	10585396	C11H17NO4	227.26	CCCC#CC[C@H](C[C@@H](C(=O)O)N)C(=O)O	Ki = 68547 nM	Poor binder
T58178	Glutamate receptor ionotropic kainate 2	B82BAO	4-[(1E,2E)-3-Phenyl-2-propene-1-ylidene]-L-glutamic acid	Investigative	44296585	C14H15NO4	261.269	C1=CC=C(C=C1)/C=C/C=C(\\C[C@@H](C(=O)O)N)/C(=O)O	Ki ~ 100000 nM	Poor binder
T58178	Glutamate receptor ionotropic kainate 2	B95TLY	2-Amino-3-(3-hydroxy-5-(2-isopropyl-2H-tetrazol-5-yl)isoxazol-4-yl)propanoic acid	Investigative	11818375	C10H14N6O4	282.26	CC(C)N1N=C(N=N1)C2=C(C(=O)NO2)CC(C(=O)O)N	Ki ~ 100000 nM	Poor binder
T58178	Glutamate receptor ionotropic kainate 2	BB69EU	4-[(E)-Cyclopentylmethylene]-L-glutamic acid	Investigative	44296355	C11H17NO4	227.26	C1CCC(C1)/C=C(\\C[C@@H](C(=O)O)N)/C(=O)O	Ki = 87600 nM	Poor binder
T58178	Glutamate receptor ionotropic kainate 2	BB8MC1	(2S,4R)-2-Amino-4-[(E)-3-naphthalen-2-ylprop-2-enyl]pentanedioic acid	Investigative	6324635	C18H19NO4	313.3	C1=CC=C2C=C(C=CC2=C1)/C=C/C[C@H](C[C@@H](C(=O)O)N)C(=O)O	EC50 ~ 100000 nM	Poor binder
T58178	Glutamate receptor ionotropic kainate 2	BCZY82	2-Amino-3-(5-(2-ethyl-2H-tetrazol-5-yl)-3-hydroxyisoxazol-4-yl)propanoic acid	Investigative	11288627	C9H12N6O4	268.23	CCN1N=C(N=N1)C2=C(C(=O)NO2)CC(C(=O)O)N	Ki ~ 100000 nM	Poor binder
T58178	Glutamate receptor ionotropic kainate 2	BD41BU	4-Chloro-2-(naphthalen-2-ylcarbamoylamino)benzoic Acid	Investigative	10132082	C18H13ClN2O3	340.8	C1=CC=C2C=C(C=CC2=C1)NC(=O)NC3=C(C=CC(=C3)Cl)C(=O)O	IC50 = 62000 nM	Poor binder
T58178	Glutamate receptor ionotropic kainate 2	BE3NM0	(2S,4E)-2-Amino-4-(2-methylpropylidene)pentanedioic acid	Investigative	10330442	C9H15NO4	201.22	CC(C)/C=C(\\C[C@@H](C(=O)O)N)/C(=O)O	Ki = 82500 nM	Poor binder
T58178	Glutamate receptor ionotropic kainate 2	BGQ59K	(3S,4Ar,6S,8aR)-6-[2-(1H-Tetrazol-5-yl)-phenylamino]-decahydro-isoquinoline-3-carboxylic acid	Investigative	11199813	C17H22N6O2	342.4	C1C[C@H]2CN[C@@H](C[C@H]2C[C@H]1NC3=CC=CC=C3C4=NNN=N4)C(=O)O	Ki ~ 100000 nM	Poor binder
T58178	Glutamate receptor ionotropic kainate 2	BH7NR6	2-Amino-3-(4-bromo-3-hydroxyisoxazol-5-YL)propanoic acid	Investigative	2733518	C6H7BrN2O4	251.03	C(C1=C(C(=O)NO1)Br)C(C(=O)O)N	Ki ~ 100000 nM	Poor binder
T58178	Glutamate receptor ionotropic kainate 2	BL09EW	(2R,3S)-1-(9-Iodophenanthrene-3-carbonyl)piperazine-2,3-dicarboxylic acid	Investigative	56945410	C21H17IN2O5	504.3	C1CN([C@H]([C@H](N1)C(=O)O)C(=O)O)C(=O)C2=CC3=C(C=C2)C=C(C4=CC=CC=C43)I	IC50 ~ 100000 nM	Poor binder
T58178	Glutamate receptor ionotropic kainate 2	BLA87M	{2-[3-(3-Bromophenyl)ureido]-4-chlorophenyl}acetic acid	Investigative	9977288	C15H12BrClN2O3	383.62	C1=CC(=CC(=C1)Br)NC(=O)NC2=C(C=CC(=C2)Cl)CC(=O)O	IC50 ~ 50000 nM	Poor binder
T58178	Glutamate receptor ionotropic kainate 2	BMQ4N3	(2R,4S)-2-(3-((Phenylcarbamoyl)methylcarbamoyl)propyl)-4-aminopentanedioic acid	Investigative	5287393	C17H23N3O6	365.4	C1=CC=C(C=C1)NC(=O)CNC(=O)CCC[C@H](C[C@@H](C(=O)O)N)C(=O)O	EC50 = 180000 nM	Poor binder
T58178	Glutamate receptor ionotropic kainate 2	BOZH40	4-[(E)-4,4-Diphenylbutylidene]-L-glutamic acid	Investigative	44296575	C21H23NO4	353.4	C1=CC=C(C=C1)C(CC/C=C(\\C[C@@H](C(=O)O)N)/C(=O)O)C2=CC=CC=C2	Ki ~ 100000 nM	Poor binder
T58178	Glutamate receptor ionotropic kainate 2	BQ8V4J	(S)-1-(2-Amino-2-carboxyethyl)-3-(2-carboxythiophene-3-ylmethyl)pyrimidine-2,4-dione	Investigative	11544633	C13H13N3O6S	339.33	C1=CN(C(=O)N(C1=O)CC2=C(SC=C2)C(=O)O)C[C@@H](C(=O)O)N	IC50 ~ 100000 nM	Poor binder
T58178	Glutamate receptor ionotropic kainate 2	BRCN73	(2S,4R)-2-Amino-4-[(E)-3-(4-chlorophenyl)prop-2-enyl]pentanedioic acid	Investigative	9861035	C14H16ClNO4	297.73	C1=CC(=CC=C1/C=C/C[C@H](C[C@@H](C(=O)O)N)C(=O)O)Cl	EC50 = 70800 nM	Poor binder
T58178	Glutamate receptor ionotropic kainate 2	BRO57L	4-[(E)-Cyclohexylmethylene]-L-glutamic acid	Investigative	44296807	C12H19NO4	241.28	C1CCC(CC1)/C=C(\\C[C@@H](C(=O)O)N)/C(=O)O	Ki ~ 100010 nM	Poor binder
T58178	Glutamate receptor ionotropic kainate 2	BY5D3O	Cl-HIBO	Investigative	4694356	C6H7ClN2O4	206.58	C(C1=C(C(=O)NO1)Cl)C(C(=O)O)N	Ki ~ 100000 nM	Poor binder
T58178	Glutamate receptor ionotropic kainate 2	D01BAG	ACET	Investigative	16125102	C20H19N3O6S	429.4	CC1=CN(C(=O)N(C1=O)CC2=C(SC(=C2)C3=CC=CC=C3)C(=O)O)C[C@@H](C(=O)O)N	IC50 ~ 100000 nM	Poor binder
T58178	Glutamate receptor ionotropic kainate 2	D03RGP	(R,S)-AMPA	Investigative	1221	C7H10N2O4	186.17	CC1=C(C(=O)NO1)CC(C(=O)O)N	Ki ~ 100000 nM	Poor binder
T58178	Glutamate receptor ionotropic kainate 2	D0K5UI	UBP310	Investigative	6420160	C14H15N3O6S	353.35	CC1=CN(C(=O)N(C1=O)CC2=C(SC=C2)C(=O)O)C[C@@H](C(=O)O)N	IC50 ~ 100000 nM	Poor binder
T58178	Glutamate receptor ionotropic kainate 2	D0T1MK	LY382884	Investigative	656723	C18H23NO4	317.4	C1C[C@H]2CN[C@@H](C[C@H]2C[C@H]1CC3=CC=C(C=C3)C(=O)O)C(=O)O	Ki ~ 100000 nM	Poor binder