TTD_Target_ID	Target_Name	TTD_Drug_ID	Drug_Name	Drug_Highest_Status	Drug_PubchemID	Molecular_Formula	Molecular_Weight	Canonical_SMILES	Activity	Binder_Type
T58970	Extracellular signal-regulated kinase 2	D0J9ZR	Niclosamide	Approved	4477	C13H8Cl2N2O4	327.12	C1=CC(=C(C=C1[N+](=O)[O-])Cl)NC(=O)C2=C(C=CC(=C2)Cl)O	IC50 ~ 100000 nM	Poor binder
T58970	Extracellular signal-regulated kinase 2	D06GXM	XHPNYYOUZWOWNT-PYUWXLGESA-N	Patented	12111413	C22H33N7O	411.5	CC[C@H](C(C(C)(C)C)O)NC1=NC(=C2C(=N1)N(C=N2)C(C)C)NCC3=CN=CC=C3	IC50 = 51000 nM	Poor binder
T58970	Extracellular signal-regulated kinase 2	D08DNZ	PMID25991433-Compound-P6	Patented	45102739	C17H12ClN5OS	369.8	C1=CC2=C(C=CN=C2)C(=C1)CC(=O)NC3=C(C(=CS3)Cl)C4=NC=NN4	IC50 ~ 50000 nM	Poor binder
T58970	Extracellular signal-regulated kinase 2	D0B6VY	AGGGWZCOULSEER-PYUWXLGESA-N	Patented	12111411	C21H31N7O	397.5	CC[C@H](C(C(C)C)O)NC1=NC(=C2C(=N1)N(C=N2)C(C)C)NCC3=CN=CC=C3	IC50 = 111000 nM	Poor binder
T58970	Extracellular signal-regulated kinase 2	D0W8BL	PMID25991433-Compound-P5	Patented	46868926	C18H11BrF3N5O2S	498.3	C1=CC2=C(C=CC(=O)N2CC(=O)NC3=C(C(=CS3)Br)C4=NC=NN4)C=C1C(F)(F)F	IC50 ~ 50000 nM	Poor binder
T58970	Extracellular signal-regulated kinase 2	B04BUQ	(3RS,4R)-4-(6-Benzylamino-9-isopropyl-9H-purin-2-ylamino)-hexan-3-ol	Investigative	10177964	C21H30N6O	382.5	CC[C@H](C(CC)O)NC1=NC(=C2C(=N1)N(C=N2)C(C)C)NCC3=CC=CC=C3	IC50 = 103000 nM	Poor binder
T58970	Extracellular signal-regulated kinase 2	B06POE	N-(3-Methoxyphenyl)-3-(4-piperidin-1-ylphenyl)pyrido[3,4-b]pyrazin-8-amine	Investigative	127030426	C25H25N5O	411.5	COC1=CC=CC(=C1)NC2=C3C(=CN=C2)N=C(C=N3)C4=CC=C(C=C4)N5CCCCC5	IC50 ~ 100000 nM	Poor binder
T58970	Extracellular signal-regulated kinase 2	B08AYZ	3-{[2-(3-Thienyl)pyridin-4-yl]amino}-4-{[(1R)-1-phenylethyl]amino}cyclobut-3-ene-1,2-dione	Investigative	44575127	C21H17N3O2S	375.4	C[C@H](C1=CC=CC=C1)NC2=C(C(=O)C2=O)NC3=CC(=NC=C3)C4=CSC=C4	IC50 ~ 50000 nM	Poor binder
T58970	Extracellular signal-regulated kinase 2	B0REW7	4-(Naphthalen-2-yl)-3-(2-(thiazol-2-ylamino)pyridin-4-yl)-1H-1,2,4-triazol-5(4H)-one	Investigative	53317414	C20H14N6OS	386.4	C1=CC=C2C=C(C=CC2=C1)N3C(=NNC3=O)C4=CC(=NC=C4)NC5=NC=CS5	IC50 ~ 50000 nM	Poor binder
T58970	Extracellular signal-regulated kinase 2	B1PW7U	N-[4-Bromo-3-(1H-1,2,4-triazol-5-yl)thiophen-2-yl]-2-(6,7-difluoro-2-oxoquinolin-1-yl)acetamide	Investigative	46868925	C17H10BrF2N5O2S	466.3	C1=CC(=O)N(C2=CC(=C(C=C21)F)F)CC(=O)NC3=C(C(=CS3)Br)C4=NC=NN4	IC50 ~ 50000 nM	Poor binder
T58970	Extracellular signal-regulated kinase 2	B1RS9X	4-(Naphthalen-2-yl)-3-(pyridin-4-yl)-1H-1,2,4-triazol-5(4H)-one	Investigative	53317412	C17H12N4O	288.3	C1=CC=C2C=C(C=CC2=C1)N3C(=NNC3=O)C4=CC=NC=C4	IC50 ~ 50000 nM	Poor binder
T58970	Extracellular signal-regulated kinase 2	B1TV6D	3-Phenyl-N-(4-piperidin-1-ylphenyl)pyrido[3,4-b]pyrazin-7-amine	Investigative	127031368	C24H23N5	381.5	C1CCN(CC1)C2=CC=C(C=C2)NC3=NC=C4C(=C3)N=CC(=N4)C5=CC=CC=C5	IC50 ~ 100000 nM	Poor binder
T58970	Extracellular signal-regulated kinase 2	B26WSU	N-(4,4''-Bithiazol-5-yl)-2-(isoquinolin-5-yl)acetamide	Investigative	49839481	C17H12N4OS2	352.4	C1=CC2=C(C=CN=C2)C(=C1)CC(=O)NC3=C(N=CS3)C4=CSC=N4	IC50 ~ 50000 nM	Poor binder
T58970	Extracellular signal-regulated kinase 2	B27PBJ	(4S,6E)-18-Hydroxy-16-methoxy-4-methyl-3-oxabicyclo[12.4.0]octadeca-1(14),6,15,17-tetraene-2,8-dione	Investigative	49842778	C19H24O5	332.4	C[C@H]1C/C=C/C(=O)CCCCCC2=C(C(=CC(=C2)OC)O)C(=O)O1	IC50 ~ 100000 nM	Poor binder
T58970	Extracellular signal-regulated kinase 2	B2CME9	N-(3-Methoxyphenyl)-2-phenylpyrido[3,4-b]pyrazin-7-amine	Investigative	127033165	C20H16N4O	328.4	COC1=CC=CC(=C1)NC2=NC=C3C(=C2)N=C(C=N3)C4=CC=CC=C4	IC50 ~ 100000 nM	Poor binder
T58970	Extracellular signal-regulated kinase 2	B2T0RU	CID 46179972	Investigative	46179972	C28H31N6O3	499.6	CC1(CC(CC(N1[O])(C)C)NC(=O)C2=CC=CC(=C2)C3=NN4C(=CC=NC4=C3)NC5=CC(=CC=C5)O)C	IC50 ~ 50000 nM	Poor binder
T58970	Extracellular signal-regulated kinase 2	B31LAW	(R)-3-(6-Benzylamino-9-isopropyl-9H-purin-2-ylamino)-2-methyl-pentan-2-ol	Investigative	10199925	C21H30N6O	382.5	CC[C@H](C(C)(C)O)NC1=NC(=C2C(=N1)N(C=N2)C(C)C)NCC3=CC=CC=C3	IC50 = 149000 nM	Poor binder
T58970	Extracellular signal-regulated kinase 2	B39IGT	4-(6-Bromonaphthalen-2-yl)-3-(2-(tetrahydro-2H-pyran-4-ylamino)pyridin-4-yl)-1H-1,2,4-triazol-5(4H)-one	Investigative	53323987	C22H20BrN5O2	466.3	C1COCCC1NC2=NC=CC(=C2)C3=NNC(=O)N3C4=CC5=C(C=C4)C=C(C=C5)Br	IC50 ~ 50000 nM	Poor binder
T58970	Extracellular signal-regulated kinase 2	B3FO6S	1-Ethyl-3-[3-[(6-methoxypyridin-3-yl)amino]pyrido[2,3-b]pyrazin-6-yl]urea	Investigative	58881868	C16H17N7O2	339.35	CCNC(=O)NC1=NC2=NC(=CN=C2C=C1)NC3=CN=C(C=C3)OC	IC50 ~ 100000 nM	Poor binder
T58970	Extracellular signal-regulated kinase 2	B3M6DB	N-[4-Cyano-3-(1h-1,2,4-Triazol-5-Yl)thiophen-2-Yl]-2-(2-Oxo-3,4-Dihydroquinolin-1(2h)-Yl)acetamide	Investigative	46869880	C18H14N6O2S	378.4	C1CC(=O)N(C2=CC=CC=C21)CC(=O)NC3=C(C(=CS3)C#N)C4=NC=NN4	IC50 ~ 50000 nM	Poor binder
T58970	Extracellular signal-regulated kinase 2	B3Q4HX	(3S)-3-[[9-Propan-2-yl-6-(pyridin-2-ylmethylamino)purin-2-yl]amino]pentan-2-ol	Investigative	57402042	C19H27N7O	369.5	CC[C@@H](C(C)O)NC1=NC(=C2C(=N1)N(C=N2)C(C)C)NCC3=CC=CC=N3	IC50 = 77000 nM	Poor binder
T58970	Extracellular signal-regulated kinase 2	B3RAE6	3-(5-Chloro-2-{[1-(dimethylamino)propan-2-yl]oxy}phenyl)-1-(5-cyanopyrazin-2-yl)urea	Investigative	11417488	C17H19ClN6O2	374.8	CC(CN(C)C)OC1=C(C=C(C=C1)Cl)NC(=O)NC2=NC=C(N=C2)C#N	IC50 ~ 50000 nM	Poor binder
T58970	Extracellular signal-regulated kinase 2	B3T9QN	Methyl 4-(6-(4-(methoxycarbonylamino)phenyl)-4-morpholino-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidine-1-carboxylate	Investigative	44219749	C24H29N7O5	495.5	COC(=O)NC1=CC=C(C=C1)C2=NC3=C(C=NN3C4CCN(CC4)C(=O)OC)C(=N2)N5CCOCC5	IC50 ~ 50000 nM	Poor binder
T58970	Extracellular signal-regulated kinase 2	B42PVG	N-(4-Morpholin-4-ylphenyl)-2-phenylpyrido[3,4-b]pyrazin-5-amine	Investigative	127031386	C23H21N5O	383.4	C1COCCN1C2=CC=C(C=C2)NC3=NC=CC4=NC(=CN=C43)C5=CC=CC=C5	IC50 ~ 100000 nM	Poor binder
T58970	Extracellular signal-regulated kinase 2	B45EMH	2-(3,4-Dihydroxybenzylidene)benzofuran-3(2H)-one	Investigative	21100709	C15H10O4	254.24	C1=CC=C2C(=C1)C(=O)/C(=C\\C3=CC(=C(C=C3)O)O)/O2	IC50 = 100000 nM	Poor binder
T58970	Extracellular signal-regulated kinase 2	B49YCA	(4S)-2,2-Dimethyl-4-[[9-propan-2-yl-6-(pyridin-2-ylmethylamino)purin-2-yl]amino]hexan-3-ol	Investigative	10001665	C22H33N7O	411.5	CC[C@@H](C(C(C)(C)C)O)NC1=NC(=C2C(=N1)N(C=N2)C(C)C)NCC3=CC=CC=N3	IC50 = 137000 nM	Poor binder
T58970	Extracellular signal-regulated kinase 2	B4EB3W	(3RS,4S)-4-(6-Benzylamino-9-isopropyl-9H-purin-2-ylamino)-2-methyl-hexan-3-ol	Investigative	10178895	C22H32N6O	396.5	CC[C@@H](C(C(C)C)O)NC1=NC(=C2C(=N1)N(C=N2)C(C)C)NCC3=CC=CC=C3	IC50 = 88000 nM	Poor binder
T58970	Extracellular signal-regulated kinase 2	B4F8MO	Schembl22388257	Investigative	56682210	C18H11BrN6O2S	455.3	C1=CC2=C(C=CC(=O)N2CC(=O)NC3=C(C(=CS3)Br)C4=NC=NN4)C=C1C#N	IC50 ~ 50000 nM	Poor binder
T58970	Extracellular signal-regulated kinase 2	B4G2QZ	Methyl 4-(6-(4-aminophenyl)-4-morpholino-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidine-1-carboxylate	Investigative	44605035	C22H27N7O3	437.5	COC(=O)N1CCC(CC1)N2C3=C(C=N2)C(=NC(=N3)C4=CC=C(C=C4)N)N5CCOCC5	IC50 ~ 50000 nM	Poor binder
T58970	Extracellular signal-regulated kinase 2	B4MJU2	2-(4-Methoxyphenyl)-5H-pyrrolo[2,3-b]pyrazine	Investigative	122193284	C13H11N3O	225.25	COC1=CC=C(C=C1)C2=CN=C3C(=N2)C=CN3	IC50 = 89700 nM	Poor binder
T58970	Extracellular signal-regulated kinase 2	B4REL1	2-(Isoquinolin-5-yl)-n-(4-(1-methyl-1h-1,2,4-triazol-5-yl)thiazol-5-yl)acetamide	Investigative	52942507	C17H14N6OS	350.4	CN1C(=NC=N1)C2=C(SC=N2)NC(=O)CC3=CC=CC4=C3C=CN=C4	IC50 ~ 50000 nM	Poor binder
T58970	Extracellular signal-regulated kinase 2	B4VE0K	1-[3-(4-Chloroanilino)pyrido[2,3-b]pyrazin-6-yl]-3-ethylurea	Investigative	58881789	C16H15ClN6O	342.78	CCNC(=O)NC1=NC2=NC(=CN=C2C=C1)NC3=CC=C(C=C3)Cl	IC50 ~ 100000 nM	Poor binder
T58970	Extracellular signal-regulated kinase 2	B5ADH9	1-Ethyl-3-[3-(4-fluoroanilino)pyrido[2,3-b]pyrazin-6-yl]urea	Investigative	58881805	C16H15FN6O	326.33	CCNC(=O)NC1=NC2=NC(=CN=C2C=C1)NC3=CC=C(C=C3)F	IC50 ~ 100000 nM	Poor binder
T58970	Extracellular signal-regulated kinase 2	B5J3GY	5-Vinyl-3-pyridinecarbonitrile, 19	Investigative	44160269	C24H28N6	400.5	CC1=C(C=CC2=C1C=CN2)NC3=C(C=NC=C3/C=C/CCN4CCC[C@H](C4)N)C#N	IC50 ~ 50000 nM	Poor binder
T58970	Extracellular signal-regulated kinase 2	B5NSE7	4-(4-Methyl-1H-indol-5-ylamino)-5-(3-(4-methylpiperazin-1-ylsulfonyl)styryl)nicotinonitrile	Investigative	45375865	C28H28N6O2S	512.6	CC1=C(C=CC2=C1C=CN2)NC3=C(C=NC=C3/C=C/C4=CC(=CC=C4)S(=O)(=O)N5CCN(CC5)C)C#N	IC50 ~ 50000 nM	Poor binder
T58970	Extracellular signal-regulated kinase 2	B5Z3KC	4-(8-Aminonaphthalen-2-yl)-3-(2-(tetrahydro-2H-pyran-4-ylamino)pyridin-4-yl)-1H-1,2,4-triazol-5(4H)-one	Investigative	53325285	C22H22N6O2	402.4	C1COCCC1NC2=NC=CC(=C2)C3=NNC(=O)N3C4=CC5=C(C=CC=C5N)C=C4	IC50 ~ 50000 nM	Poor binder
T58970	Extracellular signal-regulated kinase 2	B67LIH	2-Quinolin-5-yl-N-[2-(1H-1,2,4-triazol-5-yl)thiophen-3-yl]acetamide	Investigative	46869877	C17H13N5OS	335.4	C1=CC(=C2C=CC=NC2=C1)CC(=O)NC3=C(SC=C3)C4=NC=NN4	IC50 ~ 50000 nM	Poor binder
T58970	Extracellular signal-regulated kinase 2	B68BMG	1-Ethyl-3-[3-(naphthalen-2-ylamino)pyrido[2,3-b]pyrazin-6-yl]urea	Investigative	58881898	C20H18N6O	358.4	CCNC(=O)NC1=NC2=NC(=CN=C2C=C1)NC3=CC4=CC=CC=C4C=C3	IC50 ~ 100000 nM	Poor binder
T58970	Extracellular signal-regulated kinase 2	B6G8HM	2-(Isoquinolin-5-yl)-n-(4-(pyrazin-2-yl)thiazol-5-yl)acetamide	Investigative	52948593	C18H13N5OS	347.4	C1=CC2=C(C=CN=C2)C(=C1)CC(=O)NC3=C(N=CS3)C4=NC=CN=C4	IC50 ~ 50000 nM	Poor binder
T58970	Extracellular signal-regulated kinase 2	B6TCU4	N-(4-Morpholin-4-ylphenyl)-2-phenylpyrido[3,4-b]pyrazin-7-amine	Investigative	127031677	C23H21N5O	383.4	C1COCCN1C2=CC=C(C=C2)NC3=NC=C4C(=C3)N=C(C=N4)C5=CC=CC=C5	IC50 ~ 100000 nM	Poor binder
T58970	Extracellular signal-regulated kinase 2	B7F6VX	Methyl 4-(2-(naphthalen-1-yl)acetamido)-1H-pyrazole-3-carboxylate	Investigative	52941226	C17H15N3O3	309.32	COC(=O)C1=C(C=NN1)NC(=O)CC2=CC=CC3=CC=CC=C32	IC50 ~ 50000 nM	Poor binder
T58970	Extracellular signal-regulated kinase 2	B7I3DW	N-(2-(5-Amino-1H-1,2,4-triazol-3-yl)thiophen-3-yl)-2-(4-methoxyphenyl)acetamide	Investigative	46869742	C15H15N5O2S	329.4	COC1=CC=C(C=C1)CC(=O)NC2=C(SC=C2)C3=NC(=NN3)N	IC50 ~ 50000 nM	Poor binder
T58970	Extracellular signal-regulated kinase 2	B7JOK6	1-[7-(1-Methylpyrazol-4-yl)-1,5-naphthyridin-4-yl]-3-(2-phenylethyl)urea	Investigative	53236676	C21H20N6O	372.4	CN1C=C(C=N1)C2=CC3=NC=CC(=C3N=C2)NC(=O)NCCC4=CC=CC=C4	IC50 ~ 100000 nM	Poor binder
T58970	Extracellular signal-regulated kinase 2	B7MXG0	1-Benzyl-3-[7-(1-methylpyrazol-4-yl)-1,5-naphthyridin-4-yl]urea	Investigative	53236674	C20H18N6O	358.4	CN1C=C(C=N1)C2=CC3=NC=CC(=C3N=C2)NC(=O)NCC4=CC=CC=C4	IC50 ~ 100000 nM	Poor binder
T58970	Extracellular signal-regulated kinase 2	B7P4NU	N-(3-Ethynylphenyl)-2-phenylpyrido[3,4-b]pyrazin-5-amine	Investigative	127031076	C21H14N4	322.4	C#CC1=CC(=CC=C1)NC2=NC=CC3=NC(=CN=C32)C4=CC=CC=C4	IC50 ~ 100000 nM	Poor binder
T58970	Extracellular signal-regulated kinase 2	B82ZNP	4-(8-Fluoronaphthalen-2-yl)-3-(2-(tetrahydro-2H-pyran-4-ylamino)pyridin-4-yl)-1H-1,2,4-triazol-5(4H)-one	Investigative	53318709	C22H20FN5O2	405.4	C1COCCC1NC2=NC=CC(=C2)C3=NNC(=O)N3C4=CC5=C(C=CC=C5F)C=C4	IC50 ~ 50000 nM	Poor binder
T58970	Extracellular signal-regulated kinase 2	B8FMW1	2-Pyridin-3-yl-5H-pyrrolo[2,3-b]pyrazine	Investigative	122193401	C11H8N4	196.21	C1=CC(=CN=C1)C2=CN=C3C(=N2)C=CN3	IC50 = 71500 nM	Poor binder
T58970	Extracellular signal-regulated kinase 2	B8IA0R	3-(2-(Cyclohexylamino)pyridin-4-yl)-4-(naphthalen-2-yl)-1-(pyridin-4-ylmethyl)-1H-1,2,4-triazol-5(4H)-one	Investigative	50941539	C29H28N6O	476.6	C1CCC(CC1)NC2=NC=CC(=C2)C3=NN(C(=O)N3C4=CC5=CC=CC=C5C=C4)CC6=CC=NC=C6	IC50 ~ 50000 nM	Poor binder
T58970	Extracellular signal-regulated kinase 2	B8ISP5	N-(4-Cyano-3-(1H-1,2,4-triazol-5-yl)thiophen-2-yl)-2-(isoquinolin-5-yl)acetamide	Investigative	46868853	C18H12N6OS	360.4	C1=CC2=C(C=CN=C2)C(=C1)CC(=O)NC3=C(C(=CS3)C#N)C4=NC=NN4	IC50 ~ 50000 nM	Poor binder
T58970	Extracellular signal-regulated kinase 2	B8JNY5	3-(2-(Cyclohexylamino)pyridin-4-yl)-4-(naphthalen-2-yl)-1H-1,2,4-triazol-5(4H)-one	Investigative	50941455	C23H23N5O	385.5	C1CCC(CC1)NC2=NC=CC(=C2)C3=NNC(=O)N3C4=CC5=CC=CC=C5C=C4	IC50 ~ 50000 nM	Poor binder
T58970	Extracellular signal-regulated kinase 2	B8N0WQ	6-Chloro-9-hydroxy-1,3-dimethyl-1,9-dihydro-4H-pyrazolo[3,4-B]quinolin-4-one	Investigative	6540289	C12H10ClN3O2	263.68	CC1=NN(C2=C1C(=O)C3=C(N2O)C=CC(=C3)Cl)C	IC50 ~ 50000 nM	Poor binder
T58970	Extracellular signal-regulated kinase 2	B8N4TK	7-Chloro-1-(3,4-dichlorophenyl)-6-methoxy-3,4-dihydroisoquinoline	Investigative	44138048	C16H12Cl3NO	340.6	COC1=C(C=C2C(=C1)CCN=C2C3=CC(=C(C=C3)Cl)Cl)Cl	IC50 ~ 100000 nM	Poor binder
T58970	Extracellular signal-regulated kinase 2	B9S0YQ	1-Ethyl-3-(2-phenylpyrido[3,4-b]pyrazin-5-yl)urea	Investigative	127031075	C16H15N5O	293.32	CCNC(=O)NC1=NC=CC2=NC(=CN=C21)C3=CC=CC=C3	IC50 ~ 100000 nM	Poor binder
T58970	Extracellular signal-regulated kinase 2	B9ZS7X	N-[4-(4-Naphthalen-2-yl-5-oxo-1H-1,2,4-triazol-3-yl)pyridin-2-yl]acetamide	Investigative	53321333	C19H15N5O2	345.4	CC(=O)NC1=NC=CC(=C1)C2=NNC(=O)N2C3=CC4=CC=CC=C4C=C3	IC50 ~ 50000 nM	Poor binder
T58970	Extracellular signal-regulated kinase 2	BA62QX	4-(4-Methyl-1H-indol-5-ylamino)-2-(3-oxo-3-(pyrrolidin-1-yl)prop-1-enyl)thieno[2,3-b]pyridine-5-carbonitrile	Investigative	24766030	C24H21N5OS	427.5	CC1=C(C=CC2=C1C=CN2)NC3=C4C=C(SC4=NC=C3C#N)/C=C/C(=O)N5CCCC5	IC50 ~ 50000 nM	Poor binder
T58970	Extracellular signal-regulated kinase 2	BAX6F9	3-{5-Chloro-2-[(3-methyloxetan-3-yl)methoxy]phenyl}-1-(5-cyanopyrazin-2-yl)urea	Investigative	11406175	C17H16ClN5O3	373.8	CC1(COC1)COC2=C(C=C(C=C2)Cl)NC(=O)NC3=NC=C(N=C3)C#N	IC50 ~ 50000 nM	Poor binder
T58970	Extracellular signal-regulated kinase 2	BB2Z0H	1-[3-[(2-Chloropyridin-4-yl)amino]pyrido[2,3-b]pyrazin-6-yl]-3-ethylurea	Investigative	58881831	C15H14ClN7O	343.77	CCNC(=O)NC1=NC2=NC(=CN=C2C=C1)NC3=CC(=NC=C3)Cl	IC50 ~ 100000 nM	Poor binder
T58970	Extracellular signal-regulated kinase 2	BB4I1G	1-(3-Methoxyphenyl)-3-(2-phenylpyrido[3,4-b]pyrazin-5-yl)urea	Investigative	127030427	C21H17N5O2	371.4	COC1=CC=CC(=C1)NC(=O)NC2=NC=CC3=NC(=CN=C32)C4=CC=CC=C4	IC50 ~ 100000 nM	Poor binder
T58970	Extracellular signal-regulated kinase 2	BB4QP8	3-(2-(Cyclohexylamino)pyridin-4-yl)-4-(naphthalen-2-yl)-1-((tetrahydro-2H-pyran-4-yl)methyl)-1H-1,2,4-triazol-5(4H)-one	Investigative	53323989	C29H33N5O2	483.6	C1CCC(CC1)NC2=NC=CC(=C2)C3=NN(C(=O)N3C4=CC5=CC=CC=C5C=C4)CC6CCOCC6	IC50 ~ 50000 nM	Poor binder
T58970	Extracellular signal-regulated kinase 2	BB4SD8	1-[7-(3,4-Dimethoxyphenyl)-1,5-naphthyridin-4-yl]-3-ethylurea	Investigative	53239589	C19H20N4O3	352.4	CCNC(=O)NC1=C2C(=NC=C1)C=C(C=N2)C3=CC(=C(C=C3)OC)OC	IC50 ~ 100000 nM	Poor binder
T58970	Extracellular signal-regulated kinase 2	BBA31U	N-[4-(4-Naphthalen-2-yl-5-oxo-1H-1,2,4-triazol-3-yl)pyridin-2-yl]benzamide	Investigative	53317415	C24H17N5O2	407.4	C1=CC=C(C=C1)C(=O)NC2=NC=CC(=C2)C3=NNC(=O)N3C4=CC5=CC=CC=C5C=C4	IC50 ~ 50000 nM	Poor binder
T58970	Extracellular signal-regulated kinase 2	BBED32	4-(6-Aminonaphthalen-2-yl)-3-(2-(tetrahydro-2H-pyran-4-ylamino)pyridin-4-yl)-1H-1,2,4-triazol-5(4H)-one	Investigative	53326557	C22H22N6O2	402.4	C1COCCC1NC2=NC=CC(=C2)C3=NNC(=O)N3C4=CC5=C(C=C4)C=C(C=C5)N	IC50 ~ 50000 nM	Poor binder
T58970	Extracellular signal-regulated kinase 2	BBWU23	n-(4-Bromo-3-(1h-1,2,4-triazol-5-yl)thiophen-2-yl)-2-(isoquinolin-5-yl)acetamide	Investigative	46869878	C17H12BrN5OS	414.3	C1=CC2=C(C=CN=C2)C(=C1)CC(=O)NC3=C(C(=CS3)Br)C4=NC=NN4	IC50 ~ 50000 nM	Poor binder
T58970	Extracellular signal-regulated kinase 2	BD6A0U	4-(Naphthalen-2-yl)-3-(2-(tetrahydro-2H-pyran-4-ylamino)pyridin-4-yl)-1H-1,2,4-triazol-5(4H)-one	Investigative	53323985	C22H21N5O2	387.4	C1COCCC1NC2=NC=CC(=C2)C3=NNC(=O)N3C4=CC5=CC=CC=C5C=C4	IC50 ~ 50000 nM	Poor binder
T58970	Extracellular signal-regulated kinase 2	BD6YR7	N-Phenyl-3-(4-piperidin-1-ylphenyl)pyrido[3,4-b]pyrazin-8-amine	Investigative	127030425	C24H23N5	381.5	C1CCN(CC1)C2=CC=C(C=C2)C3=NC4=CN=CC(=C4N=C3)NC5=CC=CC=C5	IC50 ~ 100000 nM	Poor binder
T58970	Extracellular signal-regulated kinase 2	BE30YH	3-(7-(4-((1S,4S)-5-Methyl-2,5-diazabicyclo[2.2.1]heptan-2-yl)phenyl)-2-(pyridin-4-yl)pyrazolo[1,5-a]pyrimidin-3-yl)phenol	Investigative	46880136	C29H26N6O	474.6	CN1C[C@@H]2C[C@H]1CN2C3=CC=C(C=C3)C4=CC=NC5=C(C(=NN45)C6=CC=NC=C6)C7=CC(=CC=C7)O	IC50 ~ 50000 nM	Poor binder
T58970	Extracellular signal-regulated kinase 2	BE3C5W	1-Tert-butyl-3-[7-(4-hydroxy-3-methoxyphenyl)-1,5-naphthyridin-4-yl]urea	Investigative	136065819	C20H22N4O3	366.4	CC(C)(C)NC(=O)NC1=C2C(=NC=C1)C=C(C=N2)C3=CC(=C(C=C3)O)OC	IC50 ~ 100000 nM	Poor binder
T58970	Extracellular signal-regulated kinase 2	BE93CZ	2-Phenyl-5H-pyrrolo[2,3-b]pyrazine	Investigative	20784467	C12H9N3	195.22	C1=CC=C(C=C1)C2=CN=C3C(=N2)C=CN3	IC50 = 50100 nM	Poor binder
T58970	Extracellular signal-regulated kinase 2	BEM5R2	n-(4-Bromo-3-(1h-1,2,4-triazol-5-yl)thiophen-2-yl)-2-(2-oxo-3,4-dihydroquinolin-1(2h)-yl)acetamide	Investigative	46869882	C17H14BrN5O2S	432.3	C1CC(=O)N(C2=CC=CC=C21)CC(=O)NC3=C(C(=CS3)Br)C4=NC=NN4	IC50 ~ 50000 nM	Poor binder
T58970	Extracellular signal-regulated kinase 2	BGE9L7	2,3-[Ethyliminobis[ethyleneoxyethylene(1H-indole-1,3-diyl)]]maleimide	Investigative	10207821	C30H32N4O4	512.6	CCN1CCOCCN2C=C(C3=CC=CC=C32)C4=C(C5=CN(CCOCC1)C6=CC=CC=C65)C(=O)NC4=O	IC50 ~ 100000 nM	Poor binder
T58970	Extracellular signal-regulated kinase 2	BGS51N	6-Methoxy-1,2,3,4-tetrahydro-9H-pyrido[3,4-b]indole-1-carboxylic acid	Investigative	3848929	C13H14N2O3	246.26	COC1=CC2=C(C=C1)NC3=C2CCNC3C(=O)O	IC50 ~ 100000 nM	Poor binder
T58970	Extracellular signal-regulated kinase 2	BH3E9B	n-(4-Methyl-3-(3-methyl-1h-1,2,4-triazol-5-yl)thiophen-2-yl)-2-(quinolin-5-yl)acetamide	Investigative	46869817	C19H17N5OS	363.4	CC1=CSC(=C1C2=NNC(=N2)C)NC(=O)CC3=C4C=CC=NC4=CC=C3	IC50 ~ 50000 nM	Poor binder
T58970	Extracellular signal-regulated kinase 2	BH9N3O	N-(3-Methoxyphenyl)-2-phenylpyrido[3,4-b]pyrazin-5-amine	Investigative	127033758	C20H16N4O	328.4	COC1=CC=CC(=C1)NC2=NC=CC3=NC(=CN=C32)C4=CC=CC=C4	IC50 ~ 100000 nM	Poor binder
T58970	Extracellular signal-regulated kinase 2	BI1E4B	2-(4-Methoxyphenyl)-N-(2-(5-(trifluoromethyl)-1H-1,2,4-triazol-3-yl)thiophen-3-yl)acetamide	Investigative	46869740	C16H13F3N4O2S	382.4	COC1=CC=C(C=C1)CC(=O)NC2=C(SC=C2)C3=NNC(=N3)C(F)(F)F	IC50 ~ 50000 nM	Poor binder
T58970	Extracellular signal-regulated kinase 2	BI2VA4	3-[4-(4-Hydroxyphenyl)phenyl]-N-(pyridin-4-ylmethyl)-1,4-dihydroindeno[1,2-c]pyrazole-6-carboxamide	Investigative	136060555	C29H22N4O2	458.5	C1C2=C(C=CC(=C2)C(=O)NCC3=CC=NC=C3)C4=C1C(=NN4)C5=CC=C(C=C5)C6=CC=C(C=C6)O	IC50 ~ 50000 nM	Poor binder
T58970	Extracellular signal-regulated kinase 2	BI2VK9	(4S)-4-[[9-Propan-2-yl-6-(pyridin-2-ylmethylamino)purin-2-yl]amino]hexan-3-ol	Investigative	10407625	C20H29N7O	383.5	CC[C@@H](C(CC)O)NC1=NC(=C2C(=N1)N(C=N2)C(C)C)NCC3=CC=CC=N3	IC50 = 80000 nM	Poor binder
T58970	Extracellular signal-regulated kinase 2	BIE1N3	1-[7-(1-Methylpyrazol-4-yl)-1,5-naphthyridin-4-yl]-3-phenylurea	Investigative	53236443	C19H16N6O	344.4	CN1C=C(C=N1)C2=CC3=NC=CC(=C3N=C2)NC(=O)NC4=CC=CC=C4	IC50 ~ 100000 nM	Poor binder
T58970	Extracellular signal-regulated kinase 2	BIKV80	3-[[2-(2-Fluorophenyl)pyridin-4-yl]amino]-4-[[(1R)-1-phenylethyl]amino]cyclobut-3-ene-1,2-dione	Investigative	44575073	C23H18FN3O2	387.4	C[C@H](C1=CC=CC=C1)NC2=C(C(=O)C2=O)NC3=CC(=NC=C3)C4=CC=CC=C4F	IC50 ~ 50000 nM	Poor binder
T58970	Extracellular signal-regulated kinase 2	BIR3H1	3-(4'-Hydroxybiphenyl-4-Yl)-N-(4-Hydroxycyclohexyl)-1,4-Dihydroindeno[1,2-C]pyrazole-6-Carboxamide	Investigative	135589980	C29H27N3O3	465.5	C1CC(CCC1NC(=O)C2=CC3=C(C=C2)C4=C(C3)C(=NN4)C5=CC=C(C=C5)C6=CC=C(C=C6)O)O	IC50 ~ 50000 nM	Poor binder
T58970	Extracellular signal-regulated kinase 2	BIS86K	N-(4-Methyl-3-(3-methyl-1H-1,2,4-triazol-5-yl)thiophen-2-yl)-2-(2-oxo-3,4-dihydroquinolin-1(2H)-yl)acetamide	Investigative	46869674	C19H19N5O2S	381.5	CC1=CSC(=C1C2=NNC(=N2)C)NC(=O)CN3C(=O)CCC4=CC=CC=C43	IC50 ~ 50000 nM	Poor binder
T58970	Extracellular signal-regulated kinase 2	BJE4N7	1-Ethyl-3-[3-(4-methoxyanilino)pyrido[2,3-b]pyrazin-6-yl]urea	Investigative	58881819	C17H18N6O2	338.4	CCNC(=O)NC1=NC2=NC(=CN=C2C=C1)NC3=CC=C(C=C3)OC	IC50 ~ 100000 nM	Poor binder
T58970	Extracellular signal-regulated kinase 2	BJI6C7	1-Ethyl-3-[3-(3-hydroxy-4-methylanilino)pyrido[2,3-b]pyrazin-6-yl]urea	Investigative	58881874	C17H18N6O2	338.4	CCNC(=O)NC1=NC2=NC(=CN=C2C=C1)NC3=CC(=C(C=C3)C)O	IC50 ~ 100000 nM	Poor binder
T58970	Extracellular signal-regulated kinase 2	BK07WJ	N-[4-(4-Naphthalen-2-yl-5-oxo-1H-1,2,4-triazol-3-yl)pyridin-2-yl]cyclopropanecarboxamide	Investigative	53321334	C21H17N5O2	371.4	C1CC1C(=O)NC2=NC=CC(=C2)C3=NNC(=O)N3C4=CC5=CC=CC=C5C=C4	IC50 ~ 50000 nM	Poor binder
T58970	Extracellular signal-regulated kinase 2	BK2GQ1	N-Benzyl-N-methyl-4-(phenylsulfamoyl)benzamide	Investigative	27666048	C21H20N2O3S	380.5	CN(CC1=CC=CC=C1)C(=O)C2=CC=C(C=C2)S(=O)(=O)NC3=CC=CC=C3	IC50 ~ 100000 nM	Poor binder
T58970	Extracellular signal-regulated kinase 2	BK5HQ8	N-(2-Methoxyphenyl)-2-phenylpyrido[3,4-b]pyrazin-5-amine	Investigative	127031383	C20H16N4O	328.4	COC1=CC=CC=C1NC2=NC=CC3=NC(=CN=C32)C4=CC=CC=C4	IC50 ~ 100000 nM	Poor binder
T58970	Extracellular signal-regulated kinase 2	BK6XI7	Meridianin E	Investigative	9995236	C12H9BrN4O	305.13	C1=CC(=C2C(=C1O)C(=CN2)C3=NC(=NC=C3)N)Br	IC50 ~ 100000 nM	Poor binder
T58970	Extracellular signal-regulated kinase 2	BKBX35	1-Ethyl-3-[3-(pyridin-3-ylamino)pyrido[2,3-b]pyrazin-6-yl]urea	Investigative	58881916	C15H15N7O	309.33	CCNC(=O)NC1=NC2=NC(=CN=C2C=C1)NC3=CN=CC=C3	IC50 ~ 100000 nM	Poor binder
T58970	Extracellular signal-regulated kinase 2	BL3FE9	1-Ethyl-3-[3-(4-ethylanilino)pyrido[2,3-b]pyrazin-6-yl]urea	Investigative	58881857	C18H20N6O	336.4	CCC1=CC=C(C=C1)NC2=CN=C3C=CC(=NC3=N2)NC(=O)NCC	IC50 ~ 100000 nM	Poor binder
T58970	Extracellular signal-regulated kinase 2	BL73OD	1-Tert-butyl-3-[7-(3,4-dimethoxyphenyl)-1,5-naphthyridin-4-yl]urea	Investigative	53239590	C21H24N4O3	380.4	CC(C)(C)NC(=O)NC1=C2C(=NC=C1)C=C(C=N2)C3=CC(=C(C=C3)OC)OC	IC50 ~ 100000 nM	Poor binder
T58970	Extracellular signal-regulated kinase 2	BL9D4X	Methyl 5-(2-(isoquinolin-5-yl)acetamido)thiazole-4-carboxylate	Investigative	52944909	C16H13N3O3S	327.4	COC(=O)C1=C(SC=N1)NC(=O)CC2=CC=CC3=C2C=CN=C3	IC50 ~ 50000 nM	Poor binder
T58970	Extracellular signal-regulated kinase 2	BLG4W6	N-[4-Methyl-3-(1h-1,2,4-Triazol-5-Yl)thiophen-2-Yl]-2-(2-Oxo-3,4-Dihydroquinolin-1(2h)-Yl)acetamide	Investigative	46869741	C18H17N5O2S	367.4	CC1=CSC(=C1C2=NC=NN2)NC(=O)CN3C(=O)CCC4=CC=CC=C43	IC50 ~ 50000 nM	Poor binder
T58970	Extracellular signal-regulated kinase 2	BLI47D	Chembl4210146	Investigative	134129122	C10H13N5	203.24	CC1=CN=C(N=C1)NC2=C(N(N=C2)C)C	IC50 = 76000 nM	Poor binder
T58970	Extracellular signal-regulated kinase 2	BLN4I2	1-Ethyl-3-[3-(3-methylanilino)pyrido[2,3-b]pyrazin-6-yl]urea	Investigative	58881843	C17H18N6O	322.4	CCNC(=O)NC1=NC2=NC(=CN=C2C=C1)NC3=CC=CC(=C3)C	IC50 ~ 100000 nM	Poor binder
T58970	Extracellular signal-regulated kinase 2	BM50YW	(3S)-3-[[6-(Benzylamino)-9-propan-2-ylpurin-2-yl]amino]-2-methylpentan-2-ol	Investigative	10156756	C21H30N6O	382.5	CC[C@@H](C(C)(C)O)NC1=NC(=C2C(=N1)N(C=N2)C(C)C)NCC3=CC=CC=C3	IC50 = 52000 nM	Poor binder
T58970	Extracellular signal-regulated kinase 2	BMP0C7	Tert-Butyl 4-(6-(4-aminophenyl)-4-morpholino-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidine-1-carboxylate	Investigative	44605037	C25H33N7O3	479.6	CC(C)(C)OC(=O)N1CCC(CC1)N2C3=C(C=N2)C(=NC(=N3)C4=CC=C(C=C4)N)N5CCOCC5	IC50 ~ 50000 nM	Poor binder
T58970	Extracellular signal-regulated kinase 2	BMTS94	6-Methyl-4-(4-methyl-1H-indol-5-ylamino)-5-(3-(4-methylpiperazin-1-ylsulfonyl)styryl)nicotinonitrile	Investigative	45375866	C29H30N6O2S	526.7	CC1=C(C=CC2=C1C=CN2)NC3=C(C(=NC=C3C#N)C)/C=C/C4=CC(=CC=C4)S(=O)(=O)N5CCN(CC5)C	IC50 ~ 50000 nM	Poor binder
T58970	Extracellular signal-regulated kinase 2	BNA26F	(3S,5E)-1-Methyl-3-(pyridin-2-ylmethyl)-5-(pyridin-2-ylmethylidene)piperidin-4-one	Investigative	71720141	C18H19N3O	293.4	CN1C[C@@H](C(=O)/C(=C/C2=CC=CC=N2)/C1)CC3=CC=CC=N3	IC50 ~ 100000 nM	Poor binder
T58970	Extracellular signal-regulated kinase 2	BNL8G3	n-(4-Bromo-3-(1h-1,2,4-triazol-5-yl)thiophen-2-yl)-2-(quinolin-5-yl)acetamide	Investigative	46869879	C17H12BrN5OS	414.3	C1=CC(=C2C=CC=NC2=C1)CC(=O)NC3=C(C(=CS3)Br)C4=NC=NN4	IC50 ~ 50000 nM	Poor binder
T58970	Extracellular signal-regulated kinase 2	BNU51E	(3R)-3-[[9-Propan-2-yl-6-(pyridin-2-ylmethylamino)purin-2-yl]amino]pentan-2-ol	Investigative	57393383	C19H27N7O	369.5	CC[C@H](C(C)O)NC1=NC(=C2C(=N1)N(C=N2)C(C)C)NCC3=CC=CC=N3	IC50 = 73000 nM	Poor binder
T58970	Extracellular signal-regulated kinase 2	BO37RM	6-Chloro-9-hydroxy-1-methyl-3-(trifluoromethyl)-1H,4H,9H-pyrazolo[3,4-b]quinolin-4-one	Investigative	23647201	C12H7ClF3N3O2	317.65	CN1C2=C(C(=O)C3=C(N2O)C=CC(=C3)Cl)C(=N1)C(F)(F)F	IC50 ~ 50000 nM	Poor binder
T58970	Extracellular signal-regulated kinase 2	BO5W2I	3-(2-(Cyclopropylamino)pyridin-4-yl)-4-(naphthalen-2-yl)-1H-1,2,4-triazol-5(4H)-one	Investigative	53325284	C20H17N5O	343.4	C1CC1NC2=NC=CC(=C2)C3=NNC(=O)N3C4=CC5=CC=CC=C5C=C4	IC50 ~ 50000 nM	Poor binder
T58970	Extracellular signal-regulated kinase 2	BO63BH	5-[2-(Cyclohexylamino)pyridin-4-Yl]-4-Naphthalen-2-Yl-2-(Tetrahydro-2h-Pyran-4-Yl)-2,4-Dihydro-3h-1,2,4-Triazol-3-One	Investigative	50941538	C28H31N5O2	469.6	C1CCC(CC1)NC2=NC=CC(=C2)C3=NN(C(=O)N3C4=CC5=CC=CC=C5C=C4)C6CCOCC6	IC50 ~ 50000 nM	Poor binder
T58970	Extracellular signal-regulated kinase 2	BO69EM	(3R)-N-(3-Chloro-4-hydroxyphenyl)-1-[2-[4-[4-(4-fluorophenyl)phenyl]piperazin-1-yl]-2-oxoethyl]pyrrolidine-3-carboxamide	Investigative	58985147	C29H30ClFN4O3	537	C1CN(C[C@@H]1C(=O)NC2=CC(=C(C=C2)O)Cl)CC(=O)N3CCN(CC3)C4=CC=C(C=C4)C5=CC=C(C=C5)F	IC50 = 100000 nM	Poor binder
T58970	Extracellular signal-regulated kinase 2	BOF7J3	4-(Naphthalen-2-yl)-3-(2-(pyridin-2-ylamino)pyridin-4-yl)-1H-1,2,4-triazol-5(4H)-one	Investigative	53317413	C22H16N6O	380.4	C1=CC=C2C=C(C=CC2=C1)N3C(=NNC3=O)C4=CC(=NC=C4)NC5=CC=CC=N5	IC50 ~ 50000 nM	Poor binder
T58970	Extracellular signal-regulated kinase 2	BOKJ71	N-(3-Chloro-4-fluorophenyl)-3-phenylpyrido[3,4-b]pyrazin-8-amine	Investigative	127030124	C19H12ClFN4	350.8	C1=CC=C(C=C1)C2=NC3=CN=CC(=C3N=C2)NC4=CC(=C(C=C4)F)Cl	IC50 ~ 100000 nM	Poor binder
T58970	Extracellular signal-regulated kinase 2	BP32GX	(3R)-3-{9-Isopropyl-6-[(pyridin-3-ylmethyl)-amino]-9H-purin-2-ylamino}-2-methyl-pentan-2-ol	Investigative	11574520	C20H29N7O	383.5	CC[C@H](C(C)(C)O)NC1=NC(=C2C(=N1)N(C=N2)C(C)C)NCC3=CN=CC=C3	IC50 = 91000 nM	Poor binder
T58970	Extracellular signal-regulated kinase 2	BPZ32I	n-(4-Chloro-3-(1h-1,2,4-triazol-5-yl)thiophen-2-yl)-2-(2-oxo-3,4-dihydroquinolin-1(2h)-yl)acetamide	Investigative	46869673	C17H14ClN5O2S	387.8	C1CC(=O)N(C2=CC=CC=C21)CC(=O)NC3=C(C(=CS3)Cl)C4=NC=NN4	IC50 ~ 50000 nM	Poor binder
T58970	Extracellular signal-regulated kinase 2	BPZV35	(3RS,4S)-4-{9-Isopropyl-6-[(pyridin-3-ylmethyl)-amino]-9H-purin-2-ylamino}-2-methyl-hexan-3-ol	Investigative	12111412	C21H31N7O	397.5	CC[C@@H](C(C(C)C)O)NC1=NC(=C2C(=N1)N(C=N2)C(C)C)NCC3=CN=CC=C3	IC50 = 67000 nM	Poor binder
T58970	Extracellular signal-regulated kinase 2	BQ1AM8	(4S,6E,12E)-18-Hydroxy-16-methoxy-4-methyl-3-oxabicyclo[12.4.0]octadeca-1(14),6,12,15,17-pentaene-2,8-dione	Investigative	49842666	C19H22O5	330.4	C[C@H]1C/C=C/C(=O)CCC/C=C/C2=C(C(=CC(=C2)OC)O)C(=O)O1	IC50 ~ 100000 nM	Poor binder
T58970	Extracellular signal-regulated kinase 2	BQ5LG8	(3R,5E)-1-Methyl-3-(pyridin-2-ylmethyl)-5-(pyridin-2-ylmethylidene)piperidin-4-one	Investigative	71718330	C18H19N3O	293.4	CN1C[C@H](C(=O)/C(=C/C2=CC=CC=N2)/C1)CC3=CC=CC=N3	IC50 ~ 100000 nM	Poor binder
T58970	Extracellular signal-regulated kinase 2	BQJL97	n-(4-Chloro-3-(1h-1,2,4-triazol-5-yl)thiophen-2-yl)-2-(quinolin-5-yl)acetamide	Investigative	46869816	C17H12ClN5OS	369.8	C1=CC(=C2C=CC=NC2=C1)CC(=O)NC3=C(C(=CS3)Cl)C4=NC=NN4	IC50 ~ 50000 nM	Poor binder
T58970	Extracellular signal-regulated kinase 2	BQY6Z2	7-Chloro-1-(3-chlorophenyl)-6-methoxy-3,4-dihydroisoquinoline	Investigative	44138049	C16H13Cl2NO	306.2	COC1=C(C=C2C(=C1)CCN=C2C3=CC(=CC=C3)Cl)Cl	IC50 ~ 100000 nM	Poor binder
T58970	Extracellular signal-regulated kinase 2	BRN8J1	N-[3-(2-Pyridin-4-ylpyrazolo[1,5-a]pyrimidin-7-yl)phenyl]-3-(trifluoromethyl)benzamide	Investigative	24822704	C25H16F3N5O	459.4	C1=CC(=CC(=C1)NC(=O)C2=CC(=CC=C2)C(F)(F)F)C3=CC=NC4=CC(=NN34)C5=CC=NC=C5	IC50 ~ 50000 nM	Poor binder
T58970	Extracellular signal-regulated kinase 2	BSC6A4	Methyl 3-(2-(isoquinolin-5-yl)acetamido)thiophene-2-carboxylate	Investigative	52949817	C17H14N2O3S	326.4	COC(=O)C1=C(C=CS1)NC(=O)CC2=CC=CC3=C2C=CN=C3	IC50 ~ 50000 nM	Poor binder
T58970	Extracellular signal-regulated kinase 2	BSY2Z6	4-(Naphthalen-2-yl)-3-(2-(tetrahydro-2H-pyran-4-ylamino)pyridin-4-yl)-1-(tetrahydrofuran-3-yl)-1H-1,2,4-triazol-5(4H)-one	Investigative	53317416	C26H27N5O3	457.5	C1COCCC1NC2=NC=CC(=C2)C3=NN(C(=O)N3C4=CC5=CC=CC=C5C=C4)C6CCOC6	IC50 ~ 50000 nM	Poor binder
T58970	Extracellular signal-regulated kinase 2	BT0C4K	2-(4-Methoxyphenyl)-N-(2-(2-methyl-1H-imidazol-4-yl)thiophen-3-yl)acetamide	Investigative	52946092	C17H17N3O2S	327.4	CC1=NC=C(N1)C2=C(C=CS2)NC(=O)CC3=CC=C(C=C3)OC	IC50 ~ 50000 nM	Poor binder
T58970	Extracellular signal-regulated kinase 2	BT3H1C	N-(4-Methoxyphenyl)-2-phenylpyrido[3,4-b]pyrazin-5-amine	Investigative	127031384	C20H16N4O	328.4	COC1=CC=C(C=C1)NC2=NC=CC3=NC(=CN=C32)C4=CC=CC=C4	IC50 ~ 100000 nM	Poor binder
T58970	Extracellular signal-regulated kinase 2	BTO4N9	(3R)-N-(3-Chloro-4-hydroxyphenyl)-1-[2-[4-[4-(4-methoxyphenyl)phenyl]piperazin-1-yl]-2-oxoethyl]pyrrolidine-3-carboxamide	Investigative	58985303	C30H33ClN4O4	549.1	COC1=CC=C(C=C1)C2=CC=C(C=C2)N3CCN(CC3)C(=O)CN4CC[C@H](C4)C(=O)NC5=CC(=C(C=C5)O)Cl	IC50 = 50000 nM	Poor binder
T58970	Extracellular signal-regulated kinase 2	BTX12A	N-(5,6-Dimethoxy-1,3-benzothiazol-2-yl)-2-[(4-fluorophenoxy)methyl]-1,3-thiazole-4-carboxamide	Investigative	24672456	C20H16FN3O4S2	445.5	COC1=C(C=C2C(=C1)N=C(S2)NC(=O)C3=CSC(=N3)COC4=CC=C(C=C4)F)OC	IC50 = 82000 nM	Poor binder
T58970	Extracellular signal-regulated kinase 2	BU37PF	2-(4-Methoxyphenyl)-N-(2-(pyrazin-2-yl)thiophen-3-yl)acetamide	Investigative	52941286	C17H15N3O2S	325.4	COC1=CC=C(C=C1)CC(=O)NC2=C(SC=C2)C3=NC=CN=C3	IC50 ~ 50000 nM	Poor binder
T58970	Extracellular signal-regulated kinase 2	BU4D1O	2-(Isoquinolin-5-yl)-N-(2-(thiazol-4-yl)thiophen-3-yl)acetamide	Investigative	46868930	C18H13N3OS2	351.4	C1=CC2=C(C=CN=C2)C(=C1)CC(=O)NC3=C(SC=C3)C4=CSC=N4	IC50 ~ 50000 nM	Poor binder
T58970	Extracellular signal-regulated kinase 2	BU5JP9	4-(Naphthalen-2-yl)-1-(pyridin-2-ylmethyl)-3-(2-(tetrahydro-2H-pyran-4-ylamino)pyridin-4-yl)-1H-1,2,4-triazol-5(4H)-one	Investigative	53325283	C28H26N6O2	478.5	C1COCCC1NC2=NC=CC(=C2)C3=NN(C(=O)N3C4=CC5=CC=CC=C5C=C4)CC6=CC=CC=N6	IC50 ~ 50000 nM	Poor binder
T58970	Extracellular signal-regulated kinase 2	BU6KL3	n-(4-Methyl-3-(1h-1,2,4-triazol-5-yl)thiophen-2-yl)-2-(quinolin-5-yl)acetamide	Investigative	46869745	C18H15N5OS	349.4	CC1=CSC(=C1C2=NC=NN2)NC(=O)CC3=C4C=CC=NC4=CC=C3	IC50 ~ 50000 nM	Poor binder
T58970	Extracellular signal-regulated kinase 2	BVI90B	Chembl4276946	Investigative	134611886	C12H11Cl2N3O	284.14	CC1=NN(C(=C1C2=CC(=C(C=C2)Cl)Cl)N)C(=O)C	IC50 ~ 100000 nM	Poor binder
T58970	Extracellular signal-regulated kinase 2	BW65NQ	4-(Naphthalen-2-yl)-3-(2-(phenylamino)pyridin-4-yl)-1H-1,2,4-triazol-5(4H)-one	Investigative	53326556	C23H17N5O	379.4	C1=CC=C(C=C1)NC2=NC=CC(=C2)C3=NNC(=O)N3C4=CC5=CC=CC=C5C=C4	IC50 ~ 50000 nM	Poor binder
T58970	Extracellular signal-regulated kinase 2	BWAL85	2-(4-Methoxyphenyl)-N-(4-morpholin-4-ylphenyl)pyrido[3,4-b]pyrazin-5-amine	Investigative	127031675	C24H23N5O2	413.5	COC1=CC=C(C=C1)C2=CN=C3C(=N2)C=CN=C3NC4=CC=C(C=C4)N5CCOCC5	IC50 ~ 100000 nM	Poor binder
T58970	Extracellular signal-regulated kinase 2	BWSK97	4-(6-Fluoronaphthalen-2-yl)-3-(2-(tetrahydro-2H-pyran-4-ylamino)pyridin-4-yl)-1H-1,2,4-triazol-5(4H)-one	Investigative	53322645	C22H20FN5O2	405.4	C1COCCC1NC2=NC=CC(=C2)C3=NNC(=O)N3C4=CC5=C(C=C4)C=C(C=C5)F	IC50 ~ 50000 nM	Poor binder
T58970	Extracellular signal-regulated kinase 2	BX0D4P	9-Isopropyl-N*6*-(3-methyl-but-2-enyl)-9H-purine-2,6-diamine	Investigative	44315929	C13H20N6	260.339	CC(C)N1C=NC2=C(N=C(N=C21)N)NCC=C(C)C	IC50 = 50000 nM	Poor binder
T58970	Extracellular signal-regulated kinase 2	BX26EG	Methyl 3-[2-(2-thienyl)acetamido]thiophene-2-carboxylate	Investigative	2808202	C12H11NO3S2	281.4	COC(=O)C1=C(C=CS1)NC(=O)CC2=CC=CS2	IC50 ~ 50000 nM	Poor binder
T58970	Extracellular signal-regulated kinase 2	BXUQ08	3-(2-(Cyclopentylamino)pyridin-4-yl)-4-(naphthalen-2-yl)-1H-1,2,4-triazol-5(4H)-one	Investigative	53322644	C22H21N5O	371.4	C1CCC(C1)NC2=NC=CC(=C2)C3=NNC(=O)N3C4=CC5=CC=CC=C5C=C4	IC50 ~ 50000 nM	Poor binder
T58970	Extracellular signal-regulated kinase 2	BY0EP8	3-(2-(Cyclobutylamino)pyridin-4-yl)-4-(naphthalen-2-yl)-1H-1,2,4-triazol-5(4H)-one	Investigative	53323986	C21H19N5O	357.4	C1CC(C1)NC2=NC=CC(=C2)C3=NNC(=O)N3C4=CC5=CC=CC=C5C=C4	IC50 ~ 50000 nM	Poor binder
T58970	Extracellular signal-regulated kinase 2	BY0TR9	2-(4-Methoxyphenyl)-N-(2-(1-methyl-1H-imidazol-4-yl)thiophen-3-yl)acetamide	Investigative	52948565	C17H17N3O2S	327.4	CN1C=C(N=C1)C2=C(C=CS2)NC(=O)CC3=CC=C(C=C3)OC	IC50 ~ 50000 nM	Poor binder
T58970	Extracellular signal-regulated kinase 2	BY2X3B	(3R)-1-[2-[4-(4-Acetylphenyl)piperazin-1-yl]-2-oxoethyl]-N-(2-chloro-4-hydroxyphenyl)pyrrolidine-3-carboxamide	Investigative	58985119	C25H29ClN4O4	485	CC(=O)C1=CC=C(C=C1)N2CCN(CC2)C(=O)CN3CC[C@H](C3)C(=O)NC4=C(C=C(C=C4)O)Cl	IC50 = 50000 nM	Poor binder
T58970	Extracellular signal-regulated kinase 2	BY32PN	3-[6-(Ethylcarbamoylamino)pyrido[2,3-b]pyrazin-3-yl]benzamide	Investigative	58881836	C17H16N6O2	336.3	CCNC(=O)NC1=NC2=NC(=CN=C2C=C1)C3=CC(=CC=C3)C(=O)N	IC50 ~ 100000 nM	Poor binder
T58970	Extracellular signal-regulated kinase 2	BZ4S6R	4-(Naphthalen-2-yl)-1-(pyridin-2-yl)-3-(2-(tetrahydro-2H-pyran-4-ylamino)pyridin-4-yl)-1H-1,2,4-triazol-5(4H)-one	Investigative	53325286	C27H24N6O2	464.5	C1COCCC1NC2=NC=CC(=C2)C3=NN(C(=O)N3C4=CC5=CC=CC=C5C=C4)C6=CC=CC=N6	IC50 ~ 50000 nM	Poor binder
T58970	Extracellular signal-regulated kinase 2	D0YZ7H	JNJ-10198409	Investigative	9797370	C18H16FN3O2	325.3	COC1=C(C=C2C(=C1)CC3=C2NN=C3NC4=CC(=CC=C4)F)OC	IC50 ~ 100000 nM	Poor binder