TTD_Target_ID	Target_Name	TTD_Drug_ID	Drug_Name	Drug_Highest_Status	Drug_PubchemID	Molecular_Formula	Molecular_Weight	Canonical_SMILES	Activity	Binder_Type
T59929	Thymidine phosphorylase	B0SCT4	5-Amino-1-(5-O-trityl-beta-D-ribofuranosyl)imidazole-4-(N-methyl)carboxamide	Investigative	16082778	C29H30N4O5	514.6	CNC(=O)C1=C(N(C=N1)[C@H]2[C@@H]([C@@H]([C@H](O2)COC(C3=CC=CC=C3)(C4=CC=CC=C4)C5=CC=CC=C5)O)O)N	IC50 = 137000 nM	Poor binder
T59929	Thymidine phosphorylase	B0Y5WM	N-Allyl-N'-[(2,4,6-trioxotetrahydro-5(2H)-pyrimidinylidene)methyl]thiourea	Investigative	135423677	C9H10N4O3S	254.27	C=CCNC(=S)/N=C/C1=C(NC(=O)NC1=O)O	IC50 = 94800 nM	Poor binder
T59929	Thymidine phosphorylase	B0YV2R	[(E)-(1-Methyl-2,5-dioxo-4-pentylimidazolidin-4-yl)methylideneamino]urea	Investigative	9561607	C11H19N5O3	269.3	CCCCCC1(C(=O)N(C(=O)N1)C)/C=N/NC(=O)N	IC50 = 77000 nM	Poor binder
T59929	Thymidine phosphorylase	B17CDS	2-Phenyl-4H-[1,2,4]triazolo[1,5-a][1,3,5]triazine-5,7-dione	Investigative	136233532	C10H7N5O2	229.19	C1=CC=C(C=C1)C2=NN3C(=N2)NC(=O)NC3=O	IC50 ~ 100000 nM	Poor binder
T59929	Thymidine phosphorylase	B1F0YA	1-[(2-Methoxyethoxy)methyl]-5''-O-tritylinosine	Investigative	16082765	C33H34N4O7	598.6	COCCOCN1C=NC2=C(C1=O)N=CN2[C@H]3[C@@H]([C@@H]([C@H](O3)COC(C4=CC=CC=C4)(C5=CC=CC=C5)C6=CC=CC=C6)O)O	IC50 ~ 100000 nM	Poor binder
T59929	Thymidine phosphorylase	B1SU0K	5''-O-Trityl-2''deoxyinosine	Investigative	135541548	C29H26N4O4	494.5	C1[C@@H]([C@H](O[C@H]1N2C=NC3=C2N=CNC3=O)COC(C4=CC=CC=C4)(C5=CC=CC=C5)C6=CC=CC=C6)O	IC50 = 96000 nM	Poor binder
T59929	Thymidine phosphorylase	B28DHT	5-[(1,3-Dihydroxypropan-2-ylamino)methyl]-6-hydroxy-4-methyl-2-oxo-1H-pyridine-3-carbonitrile	Investigative	72711418	C11H15N3O4	253.25	CC1=C(C(=O)NC(=C1CNC(CO)CO)O)C#N	IC50 ~ 100000 nM	Poor binder
T59929	Thymidine phosphorylase	B2QBG4	5-Chloro-6-[(4'-nitroimidazol-1'-yl)methyl]uracil	Investigative	11219482	C8H6ClN5O4	271.62	C1=C(N=CN1CC2=C(C(=O)NC(=O)N2)Cl)[N+](=O)[O-]	IC50 = 200000 nM	Poor binder
T59929	Thymidine phosphorylase	B2U5PI	7-(3-Benzylguanidino)-1,2,3,4-tetrahydrothieno[3,2-d]pyrimidine-2,4-dione	Investigative	10470961	C14H13N5O2S	315.35	C1=CC=C(C=C1)CN=C(N)NC2=CSC3=C2NC(=O)NC3=O	Ki = 64300 nM	Poor binder
T59929	Thymidine phosphorylase	B4GHE3	6-[(3-Phenylpropyl)amino]uracil	Investigative	309829	C13H15N3O2	245.28	C1=CC=C(C=C1)CCCNC2=CC(=O)NC(=O)N2	IC50 = 82000 nM	Poor binder
T59929	Thymidine phosphorylase	B51DUE	3-[(2-Methylphenyl)methyl]isochromen-1-one	Investigative	134131196	C17H14O2	250.29	CC1=CC=CC=C1CC2=CC3=CC=CC=C3C(=O)O2	IC50 = 61000 nM	Poor binder
T59929	Thymidine phosphorylase	B5T2HG	5-Amino-1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(trityloxymethyl)oxolan-2-yl]-N-(2-methoxyethoxymethyl)imidazole-4-carboxamide	Investigative	16082771	C32H36N4O7	588.6	COCCOCNC(=O)C1=C(N(C=N1)[C@H]2[C@@H]([C@@H]([C@H](O2)COC(C3=CC=CC=C3)(C4=CC=CC=C4)C5=CC=CC=C5)O)O)N	IC50 ~ 75000 nM	Poor binder
T59929	Thymidine phosphorylase	B67BWO	Chembl4292894	Investigative	145987666	C13H13N3O3	259.26	CC1=CC(=O)NC(=O)N1/C(=N/OC)/C2=CC=CC=C2	IC50 = 85600 nM	Poor binder
T59929	Thymidine phosphorylase	B6D1VA	5'-O-Tritylinosine	Investigative	135526599	C29H26N4O5	510.5	C1=CC=C(C=C1)C(C2=CC=CC=C2)(C3=CC=CC=C3)OC[C@@H]4[C@H]([C@H]([C@@H](O4)N5C=NC6=C5N=CNC6=O)O)O	IC50 = 67000 nM	Poor binder
T59929	Thymidine phosphorylase	B6N8BQ	4-[(7-Oxo-5-sulfanylidene-1H-[1,2,4]triazolo[1,5-a][1,3,5]triazin-2-yl)methyl]benzonitrile	Investigative	72374616	C12H8N6OS	284.3	C1=CC(=CC=C1CC2=NC3=NC(=S)NC(=O)N3N2)C#N	IC50 = 64330 nM	Poor binder
T59929	Thymidine phosphorylase	B6NI8L	Acetic acid;2-(2,4-dioxo-1H-thieno[3,2-d]pyrimidin-7-yl)guanidine	Investigative	49795955	C9H11N5O4S	285.28	CC(=O)O.C1=C(C2=C(S1)C(=O)NC(=O)N2)N=C(N)N	Ki = 76000 nM	Poor binder
T59929	Thymidine phosphorylase	B6TF7E	2,6-Dihydroxy-4-methyl-3-pyridinecarbonitrile	Investigative	79516	C7H6N2O2	150.13	CC1=CC(=O)NC(=C1C#N)O	IC50 ~ 100000 nM	Poor binder
T59929	Thymidine phosphorylase	B7R5TK	5-Chloro-6-(2-nitro-imidazol-1-ylmethyl)-1H-pyrimidine-2,4-dione	Investigative	11022009	C8H6ClN5O4	271.62	C1=CN(C(=N1)[N+](=O)[O-])CC2=C(C(=O)NC(=O)N2)Cl	IC50 = 115000 nM	Poor binder
T59929	Thymidine phosphorylase	B7TDY2	4-Amino-1-(2,6-dioxo-1,2,3,6-tetrahydro-pyrimidin-4-ylmethyl)-3H-imidazol-1-ium	Investigative	11334014	C8H10N5O2+	208.2	C1=C(NC(=O)NC1=O)C[N+]2=CNC(=C2)N	IC50 = 143000 nM	Poor binder
T59929	Thymidine phosphorylase	B7VT6P	5-[(Dimethylamino)methyl]-6-hydroxy-4-methyl-2-oxo-1H-pyridine-3-carbonitrile	Investigative	13115629	C10H13N3O2	207.23	CC1=C(C(=O)NC(=C1CN(C)C)O)C#N	IC50 ~ 100000 nM	Poor binder
T59929	Thymidine phosphorylase	B80VOD	[8-[(4-Cyanophenyl)methyl]-4-oxo-2-sulfanylidene-6H-pyrazolo[1,5-a][1,3,5]triazin-7-yl]thiourea	Investigative	90654810	C14H11N7OS2	357.4	C1=CC(=CC=C1CC2=C(NN3C2=NC(=S)NC3=O)NC(=S)N)C#N	IC50 = 51522.86 nM	Poor binder
T59929	Thymidine phosphorylase	B8CL5J	5-Bromo-6-(4-nitro-imidazol-1-ylmethyl)-1H-pyrimidine-2,4-dione	Investigative	11336042	C8H6BrN5O4	316.07	C1=C(N=CN1CC2=C(C(=O)NC(=O)N2)Br)[N+](=O)[O-]	IC50 = 181000 nM	Poor binder
T59929	Thymidine phosphorylase	B92JHT	Chembl4277363	Investigative	145985840	C11H7FIN3O3	375.09	C1=CC=C(C(=C1)/C(=N\\O)/N2C=C(C(=O)NC2=O)I)F	IC50 = 53700 nM	Poor binder
T59929	Thymidine phosphorylase	B93CDN	5-[(2,3-Dihydroxypropylamino)methyl]-6-hydroxy-4-methyl-2-oxo-1H-pyridine-3-carbonitrile	Investigative	72711419	C11H15N3O4	253.25	CC1=C(C(=O)NC(=C1CNCC(CO)O)O)C#N	IC50 ~ 100000 nM	Poor binder
T59929	Thymidine phosphorylase	BA0BV6	6-(4-Phenylbutylamino)uracil	Investigative	309844	C14H17N3O2	259.3	C1=CC=C(C=C1)CCCCNC2=CC(=O)NC(=O)N2	IC50 = 74000 nM	Poor binder
T59929	Thymidine phosphorylase	BA5Q1U	2,4(1H,3H)-Pyrimidinedione, 6-[(2-phenylethyl)amino]-	Investigative	308653	C12H13N3O2	231.25	C1=CC=C(C=C1)CCNC2=CC(=O)NC(=O)N2	IC50 = 148000 nM	Poor binder
T59929	Thymidine phosphorylase	BBWL48	[8-[(4-Methoxyphenyl)methyl]-4-oxo-2-sulfanylidene-6H-pyrazolo[1,5-a][1,3,5]triazin-7-yl]thiourea	Investigative	90654820	C14H14N6O2S2	362.4	COC1=CC=C(C=C1)CC2=C(NN3C2=NC(=S)NC3=O)NC(=S)N	IC50 = 51404.37 nM	Poor binder
T59929	Thymidine phosphorylase	BF8K7I	2,6-Dihydroxy-3-cyanopyridine	Investigative	100608	C6H4N2O2	136.11	C1=CC(=O)NC(=C1C#N)O	IC50 ~ 100000 nM	Poor binder
T59929	Thymidine phosphorylase	BO3C7X	5-Bromo-6-[(2'-nitroimidazol-1'-yl)methyl]uracil	Investigative	10358357	C8H6BrN5O4	316.07	C1=CN(C(=N1)[N+](=O)[O-])CC2=C(C(=O)NC(=O)N2)Br	IC50 = 160000 nM	Poor binder
T59929	Thymidine phosphorylase	BPY46S	Chembl4287578	Investigative	11160569	C12H10N2O3	230.22	CC1=CC(=O)NC(=O)N1C(=O)C2=CC=CC=C2	IC50 = 92400 nM	Poor binder
T59929	Thymidine phosphorylase	BQ0VU1	6-Hydroxy-5-[(2-hydroxyethylamino)methyl]-4-methyl-2-oxo-1H-pyridine-3-carbonitrile	Investigative	72711417	C10H13N3O3	223.23	CC1=C(C(=O)NC(=C1CNCCO)O)C#N	IC50 ~ 100000 nM	Poor binder
T59929	Thymidine phosphorylase	BR84EO	2-Benzyl-4H-[1,2,4]triazolo[1,5-a][1,3,5]triazine-5,7-dione	Investigative	136233533	C11H9N5O2	243.22	C1=CC=C(C=C1)CC2=NN3C(=N2)NC(=O)NC3=O	IC50 ~ 100000 nM	Poor binder
T59929	Thymidine phosphorylase	BUEL58	3-[[2-[(2S,3R,4R,5S,6R)-6-(Benzoyloxymethyl)-3,4,5-trihydroxyoxan-2-yl]oxy-5-hydroxyphenyl]methoxy]-2-hydroxybenzoic acid	Investigative	134131292	C27H26O12	542.5	C1=CC=C(C=C1)C(=O)OC[C@@H]2[C@H]([C@H]([C@H]([C@@H](O2)OC3=C(C=C(C=C3)O)COC4=CC=CC(=C4O)C(=O)O)O)O)O	IC50 = 65450 nM	Poor binder
T59929	Thymidine phosphorylase	BUQ97X	7-Tert-butyl-2-sulfanylidene-6H-pyrazolo[1,5-a][1,3,5]triazin-4-one	Investigative	71741142	C9H12N4OS	224.29	CC(C)(C)C1=CC2=NC(=S)NC(=O)N2N1	IC50 = 55700 nM	Poor binder