TTD_Target_ID	Target_Name	TTD_Drug_ID	Drug_Name	Drug_Highest_Status	Drug_PubchemID	Molecular_Formula	Molecular_Weight	Canonical_SMILES	Activity	Binder_Type
T61400	Dihydroorotate dehydrogenase	D0G7UX	Cyclosporin A	Phase 2	5284373	C62H111N11O12	1202.6	CC[C@H]1C(=O)N(CC(=O)N([C@H](C(=O)N[C@H](C(=O)N([C@H](C(=O)N[C@H](C(=O)N[C@@H](C(=O)N([C@H](C(=O)N([C@H](C(=O)N([C@H](C(=O)N([C@H](C(=O)N1)[C@@H]([C@H](C)C/C=C/C)O)C)C(C)C)C)CC(C)C)C)CC(C)C)C)C)C)CC(C)C)C)C(C)C)CC(C)C)C)C	IC50 ~ 50000 nM	Poor binder
T61400	Dihydroorotate dehydrogenase	B01SIZ	Ethyl (E)-3-(dibenzothiophen-2-ylamino)-2-nitroprop-2-enoate	Investigative	137641335	C17H14N2O4S	342.4	CCOC(=O)/C(=C\\NC1=CC2=C(C=C1)SC3=CC=CC=C32)/[N+](=O)[O-]	IC50 ~ 100000 nM	Poor binder
T61400	Dihydroorotate dehydrogenase	B05WQG	2-Aminoethanol;5-[2-(4-carboxyphenyl)ethyl]-2,4-dioxo-1H-pyrimidine-6-carboxylic acid	Investigative	134146144	C18H26N4O8	426.4	C1=CC(=CC=C1CCC2=C(NC(=O)NC2=O)C(=O)O)C(=O)O.C(CO)N.C(CO)N	Ki ~ 125000 nM	Poor binder
T61400	Dihydroorotate dehydrogenase	B06TKP	5-Methyl-N-tetralin-6-yl-[1,2,4]triazolo[1,5-a]pyrimidin-7-amine	Investigative	44133952	C16H17N5	279.34	CC1=NC2=NC=NN2C(=C1)NC3=CC4=C(CCCC4)C=C3	IC50 ~ 100000 nM	Poor binder
T61400	Dihydroorotate dehydrogenase	B08NPQ	N-(4-Isopropylphenyl)-5-methyl-[1,2,4]triazolo[1,5-a]pyrimidin-7-amine	Investigative	5308416	C15H17N5	267.33	CC1=NC2=NC=NN2C(=C1)NC3=CC=C(C=C3)C(C)C	IC50 ~ 100000 nM	Poor binder
T61400	Dihydroorotate dehydrogenase	B0CH7G	5-Pyridin-4-yl-3-(4-trifluoromethyl-phenylamino)-1H-pyrazole-4-carbonitrile	Investigative	10830186	C16H10F3N5	329.28	C1=CC(=CC=C1C(F)(F)F)NC2=NNC(=C2C#N)C3=CC=NC=C3	IC50 ~ 50000 nM	Poor binder
T61400	Dihydroorotate dehydrogenase	B0DL2Y	2-(1,1-Difluoropropyl)-5-methyl-N-[4-(pentafluoro-lambda6-sulfanyl)phenyl]-[1,2,4]triazolo[1,5-a]pyrimidin-7-amine	Investigative	51347543	C15H14F7N5S	429.4	CCC(C1=NN2C(=CC(=NC2=N1)C)NC3=CC=C(C=C3)S(F)(F)(F)(F)F)(F)F	IC50 ~ 100000 nM	Poor binder
T61400	Dihydroorotate dehydrogenase	B0HZO9	N-(4-Tert-butylphenyl)-5-methyl-[1,2,4]triazolo[1,5-a]pyrimidin-7-amine	Investigative	8850862	C16H19N5	281.36	CC1=NC2=NC=NN2C(=C1)NC3=CC=C(C=C3)C(C)(C)C	IC50 ~ 100000 nM	Poor binder
T61400	Dihydroorotate dehydrogenase	B0P7XE	7-Methyl-N-[4-(trifluoromethyl)phenyl]imidazo[1,2-a]pyrimidin-5-amine	Investigative	51347106	C14H11F3N4	292.26	CC1=NC2=NC=CN2C(=C1)NC3=CC=C(C=C3)C(F)(F)F	IC50 ~ 100000 nM	Poor binder
T61400	Dihydroorotate dehydrogenase	B0RC6M	N-(4-Ethylphenyl)-5-methyl-[1,2,4]triazolo[1,5-a]pyrimidin-7-amine	Investigative	777191	C14H15N5	253.3	CCC1=CC=C(C=C1)NC2=CC(=NC3=NC=NN23)C	IC50 ~ 100000 nM	Poor binder
T61400	Dihydroorotate dehydrogenase	B0TU6X	2-Isopropyl-5-methyl-N-[4-(trifluoromethyl)phenyl]-[1,2,4]triazolo[1,5-a]pyrimidin-7-amine	Investigative	51347541	C16H16F3N5	335.33	CC1=NC2=NC(=NN2C(=C1)NC3=CC=C(C=C3)C(F)(F)F)C(C)C	IC50 ~ 100000 nM	Poor binder
T61400	Dihydroorotate dehydrogenase	B0VT1F	Cinchophen	Investigative	8593	C16H11NO2	249.26	C1=CC=C(C=C1)C2=NC3=CC=CC=C3C(=C2)C(=O)O	IC50 = 144000 nM	Poor binder
T61400	Dihydroorotate dehydrogenase	B18XMT	5-Methyl-N-(2-naphthyl)pyrazolo[1,5-a]pyrimidin-7-amine	Investigative	44133953	C17H14N4	274.32	CC1=NC2=CC=NN2C(=C1)NC3=CC4=CC=CC=C4C=C3	IC50 ~ 100000 nM	Poor binder
T61400	Dihydroorotate dehydrogenase	B1EP2J	2-(1,1-Difluoropropyl)-5-methyl-N-[4-(trifluoromethyl)phenyl]-[1,2,4]triazolo[1,5-a]pyrimidin-7-amine	Investigative	51347542	C16H14F5N5	371.31	CCC(C1=NN2C(=CC(=NC2=N1)C)NC3=CC=C(C=C3)C(F)(F)F)(F)F	IC50 ~ 100000 nM	Poor binder
T61400	Dihydroorotate dehydrogenase	B1WPJ3	N-(1,3-Benzodioxol-5-yl)-5-methyl-[1,2,4]triazolo[1,5-a]pyrimidin-7-amine	Investigative	22431257	C13H11N5O2	269.26	CC1=NC2=NC=NN2C(=C1)NC3=CC4=C(C=C3)OCO4	IC50 ~ 100000 nM	Poor binder
T61400	Dihydroorotate dehydrogenase	B1Y0BI	2-[4-(2-Acetamidophenyl)phenyl]-1H-benzimidazole-4-carboxamide	Investigative	122182312	C22H18N4O2	370.4	CC(=O)NC1=CC=CC=C1C2=CC=C(C=C2)C3=NC4=C(C=CC=C4N3)C(=O)N	IC50 = 51000 nM	Poor binder
T61400	Dihydroorotate dehydrogenase	B20MIL	7-Methyl-N-(2-naphthyl)imidazo[1,2-a]pyrimidin-5-amine	Investigative	44133954	C17H14N4	274.32	CC1=NC2=NC=CN2C(=C1)NC3=CC4=CC=CC=C4C=C3	IC50 ~ 100000 nM	Poor binder
T61400	Dihydroorotate dehydrogenase	B25XCI	2-[(4-Methoxyphenyl)methylsulfanyl]-5-methyl-[1,2,4]triazolo[1,5-a]pyrimidin-7-ol	Investigative	60166481	C14H14N4O2S	302.35	CC1=CC(=O)N2C(=N1)N=C(N2)SCC3=CC=C(C=C3)OC	IC50 = 63000 nM	Poor binder
T61400	Dihydroorotate dehydrogenase	B2HU3Y	2-Tert-butyl-5-methyl-N-[4-(pentafluoro-lambda6-sulfanyl)phenyl]-[1,2,4]triazolo[1,5-a]pyrimidin-7-amine	Investigative	53392616	C16H18F5N5S	407.4	CC1=NC2=NC(=NN2C(=C1)NC3=CC=C(C=C3)S(F)(F)(F)(F)F)C(C)(C)C	IC50 ~ 100000 nM	Poor binder
T61400	Dihydroorotate dehydrogenase	B2JRG9	3-[3-(4-Tert-butylphenyl)phenyl]-5-carbamoylbenzoic acid	Investigative	10690749	C24H23NO3	373.4	CC(C)(C)C1=CC=C(C=C1)C2=CC(=CC=C2)C3=CC(=CC(=C3)C(=O)O)C(=O)N	Ki = 90000 nM	Poor binder
T61400	Dihydroorotate dehydrogenase	B2PUG7	5-Hexyl-isoxazole-4-carbothioic acid (4-trifluoromethyl-phenyl)-amide	Investigative	44310381	C17H19F3N2OS	356.4	CCCCCCC1=C(C=NO1)C(=S)NC2=CC=C(C=C2)C(F)(F)F	IC50 ~ 50000 nM	Poor binder
T61400	Dihydroorotate dehydrogenase	B2V0XB	5-Methyl-N-[4-(trifluoromethyl)phenyl][1,2,4]triazolo[1,5-a]pyrimidin-7-amine	Investigative	25263414	C13H10F3N5	293.25	CC1=NC2=NC=NN2C(=C1)NC3=CC=C(C=C3)C(F)(F)F	IC50 ~ 100000 nM	Poor binder
T61400	Dihydroorotate dehydrogenase	B2YX9B	2-(4-Chlorophenyl)-3-hydroxy-8-(trifluoromethoxy)quinoline-4-carboxylic acid	Investigative	16100004	C17H9ClF3NO4	383.7	C1=CC2=C(C(=C(N=C2C(=C1)OC(F)(F)F)C3=CC=C(C=C3)Cl)O)C(=O)O	IC50 = 130000 nM	Poor binder
T61400	Dihydroorotate dehydrogenase	B2YZ3N	6-Methyl-2-[4-[5-(pyrrolidine-1-carbonyl)pyridin-3-yl]phenyl]-1H-benzimidazole-4-carboxamide	Investigative	122182309	C25H23N5O2	425.5	CC1=CC(=C2C(=C1)NC(=N2)C3=CC=C(C=C3)C4=CC(=CN=C4)C(=O)N5CCCC5)C(=O)N	IC50 = 50000 nM	Poor binder
T61400	Dihydroorotate dehydrogenase	B35UCR	5-Cyclopropyl-isoxazole-4-carbothioic acid (4-dimethylamino-phenyl)-amide	Investigative	44310624	C15H17N3OS	287.4	CN(C)C1=CC=C(C=C1)NC(=S)C2=C(ON=C2)C3CC3	IC50 ~ 50000 nM	Poor binder
T61400	Dihydroorotate dehydrogenase	B3EP2R	N-[4-Chloro-3-(trifluoromethyl)phenyl]-5-methyl-[1,2,4]triazolo[1,5-a]pyrimidin-7-amine	Investigative	7416167	C13H9ClF3N5	327.69	CC1=NC2=NC=NN2C(=C1)NC3=CC(=C(C=C3)Cl)C(F)(F)F	IC50 ~ 100000 nM	Poor binder
T61400	Dihydroorotate dehydrogenase	B3IKT1	2-[4-[5-(Pyrrolidin-1-ylmethyl)pyridin-3-yl]phenyl]-1H-benzimidazole-4-carboxamide	Investigative	122182318	C24H23N5O	397.5	C1CCN(C1)CC2=CC(=CN=C2)C3=CC=C(C=C3)C4=NC5=C(C=CC=C5N4)C(=O)N	IC50 = 55000 nM	Poor binder
T61400	Dihydroorotate dehydrogenase	B3LJY0	N-Benzyl-N'-[4-(pyrrolidine-1-ylcarbonyl)phenyl]-1-(4-methoxyphenyl)-1H-pyrazole-3,5-dicarboxamide	Investigative	10029745	C30H29N5O4	523.6	COC1=CC=C(C=C1)N2C(=CC(=N2)C(=O)NCC3=CC=CC=C3)C(=O)NC4=CC=C(C=C4)C(=O)N5CCCC5	Ki ~ 50000 nM	Poor binder
T61400	Dihydroorotate dehydrogenase	B3M7CK	5-Methyl-4-(4-trifluoromethylphenyl)aminothiocarbonylisoxazole	Investigative	15858807	C12H9F3N2OS	286.27	CC1=C(C=NO1)C(=S)NC2=CC=C(C=C2)C(F)(F)F	IC50 ~ 50000 nM	Poor binder
T61400	Dihydroorotate dehydrogenase	B3RCQ6	2-Benzylsulfanyl-5-methyl-[1,2,4]triazolo[1,5-a]pyrimidin-7-amine	Investigative	60166618	C13H13N5S	271.34	CC1=NC2=NC(=NN2C(=C1)N)SCC3=CC=CC=C3	IC50 ~ 100000 nM	Poor binder
T61400	Dihydroorotate dehydrogenase	B3T0DU	3-(3,5-Bis-trifluoromethyl-phenylamino)-5-methyl-1H-pyrazole-4-carbonitrile	Investigative	10711746	C13H8F6N4	334.22	CC1=C(C(=NN1)NC2=CC(=CC(=C2)C(F)(F)F)C(F)(F)F)C#N	IC50 ~ 50000 nM	Poor binder
T61400	Dihydroorotate dehydrogenase	B3T4LR	6-(4-Carboxyphenyl)-2-(4-chlorophenyl)-3-hydroxyquinoline-4-carboxylic acid	Investigative	16099935	C23H14ClNO5	419.8	C1=CC(=CC=C1C2=CC3=C(C=C2)N=C(C(=C3C(=O)O)O)C4=CC=C(C=C4)Cl)C(=O)O	IC50 = 135000 nM	Poor binder
T61400	Dihydroorotate dehydrogenase	B45YMO	N-(5-Methyl-[1,2,4]triazolo[1,5-a]pyrimidin-7-yl)benzamide	Investigative	71457078	C13H11N5O	253.26	CC1=NC2=NC=NN2C(=C1)NC(=O)C3=CC=CC=C3	IC50 ~ 100000 nM	Poor binder
T61400	Dihydroorotate dehydrogenase	B46HGE	3-N-Benzhydryl-5-N-benzyl-1-(4-methoxyphenyl)pyrazole-3,5-dicarboxamide	Investigative	11135071	C32H28N4O3	516.6	COC1=CC=C(C=C1)N2C(=CC(=N2)C(=O)NC(C3=CC=CC=C3)C4=CC=CC=C4)C(=O)NCC5=CC=CC=C5	Ki ~ 50000 nM	Poor binder
T61400	Dihydroorotate dehydrogenase	B4AMX7	5-Cyclohexyl-isoxazole-4-carbothioic acid (4-dimethylamino-phenyl)-amide	Investigative	44310384	C18H23N3OS	329.5	CN(C)C1=CC=C(C=C1)NC(=S)C2=C(ON=C2)C3CCCCC3	IC50 ~ 50000 nM	Poor binder
T61400	Dihydroorotate dehydrogenase	B4BEM8	N-(3,4-Bis(trifluoromethyl)phenyl)-5-methyl-[1,2,4]triazolo[1,5-a]pyrimidin-7-amine	Investigative	51347394	C14H9F6N5	361.24	CC1=NC2=NC=NN2C(=C1)NC3=CC(=C(C=C3)C(F)(F)F)C(F)(F)F	IC50 ~ 100000 nM	Poor binder
T61400	Dihydroorotate dehydrogenase	B4DTM0	(2S,3S,4S)-2-Cyano-3-(4-((3-fluorophenyl)ethynyl)phenyl)-4-(hydroxymethyl)-N-propylazetidine-1-carboxamide	Investigative	54650356	C23H22FN3O2	391.4	CCCNC(=O)N1[C@@H]([C@H]([C@H]1C#N)C2=CC=C(C=C2)C#CC3=CC(=CC=C3)F)CO	IC50 ~ 50000 nM	Poor binder
T61400	Dihydroorotate dehydrogenase	B4NTA5	2-Butan-2-yl-5-methyl-N-[4-(trifluoromethyl)phenyl]-[1,2,4]triazolo[1,5-a]pyrimidin-7-amine	Investigative	53392617	C17H18F3N5	349.35	CCC(C)C1=NN2C(=CC(=NC2=N1)C)NC3=CC=C(C=C3)C(F)(F)F	IC50 ~ 100000 nM	Poor binder
T61400	Dihydroorotate dehydrogenase	B51OVZ	2-Aminoethanol;5-[4-(3-methoxycarbonylphenyl)butyl]-2,4-dioxo-1H-pyrimidine-6-carboxylic acid	Investigative	134135269	C19H25N3O7	407.4	COC(=O)C1=CC=CC(=C1)CCCCC2=C(NC(=O)NC2=O)C(=O)O.C(CO)N	Ki = 73500 nM	Poor binder
T61400	Dihydroorotate dehydrogenase	B54FDM	5-Methyl-N-[4-methyl-3-(trifluoromethyl)phenyl]-[1,2,4]triazolo[1,5-a]pyrimidin-7-amine	Investigative	25263432	C14H12F3N5	307.27	CC1=C(C=C(C=C1)NC2=CC(=NC3=NC=NN23)C)C(F)(F)F	IC50 ~ 100000 nM	Poor binder
T61400	Dihydroorotate dehydrogenase	B5GPS8	Ethyl (Z)-2-cyano-3-[(9-ethylcarbazol-3-yl)amino]prop-2-enoate	Investigative	16102642	C20H19N3O2	333.4	CCN1C2=C(C=C(C=C2)N/C=C(/C#N)\\C(=O)OCC)C3=CC=CC=C31	Ki = 60400 nM	Poor binder
T61400	Dihydroorotate dehydrogenase	B5M4PQ	1-(4-Chlorophenyl)-5-N-phenyl-3-N-(pyridin-3-ylmethyl)pyrazole-3,5-dicarboxamide	Investigative	10048413	C23H18ClN5O2	431.9	C1=CC=C(C=C1)NC(=O)C2=CC(=NN2C3=CC=C(C=C3)Cl)C(=O)NCC4=CN=CC=C4	Ki ~ 50000 nM	Poor binder
T61400	Dihydroorotate dehydrogenase	B67HUS	3-[Methyl[4-(trifluoromethyl)phenyl]amino]-5-methyl-1H-pyrazole-4-carbonitrile	Investigative	10516844	C13H11F3N4	280.25	CC1=C(C(=NN1)N(C)C2=CC=C(C=C2)C(F)(F)F)C#N	IC50 ~ 50000 nM	Poor binder
T61400	Dihydroorotate dehydrogenase	B67YBJ	5-Methyl-N-(4-pentylphenyl)-[1,2,4]triazolo[1,5-a]pyrimidin-7-amine	Investigative	44131575	C17H21N5	295.4	CCCCCC1=CC=C(C=C1)NC2=CC(=NC3=NC=NN23)C	IC50 ~ 100000 nM	Poor binder
T61400	Dihydroorotate dehydrogenase	B6C9ME	5-Hexyl-isoxazole-4-carbothioic acid (4-cyano-phenyl)-amide	Investigative	44310720	C17H19N3OS	313.4	CCCCCCC1=C(C=NO1)C(=S)NC2=CC=C(C=C2)C#N	IC50 ~ 50000 nM	Poor binder
T61400	Dihydroorotate dehydrogenase	B6H5JP	2-(4-Chlorophenyl)-3-hydroxy-7,8-dimethylquinoline-4-carboxylicacid	Investigative	16099905	C18H14ClNO3	327.8	CC1=C(C2=NC(=C(C(=C2C=C1)C(=O)O)O)C3=CC=C(C=C3)Cl)C	IC50 = 72000 nM	Poor binder
T61400	Dihydroorotate dehydrogenase	B6I1AK	CID 53392537	Investigative	53392537	C17H18F3N5	349.35	CC1=NC2=NC(=NN2C(=C1)NC3=CC=C(C=C3)C(F)(F)F)C(C)(C)C	IC50 ~ 100000 nM	Poor binder
T61400	Dihydroorotate dehydrogenase	B6I5DP	2-Aminoethanol;5-[4-(5-carboxynaphthalen-2-yl)butyl]-2,4-dioxo-1H-pyrimidine-6-carboxylic acid	Investigative	134157042	C24H32N4O8	504.5	C1=CC2=C(C=CC(=C2)CCCCC3=C(NC(=O)NC3=O)C(=O)O)C(=C1)C(=O)O.C(CO)N.C(CO)N	Ki = 76000 nM	Poor binder
T61400	Dihydroorotate dehydrogenase	B6UI3X	Ethyl (Z)-3-[(9-ethylcarbazol-3-yl)amino]-2-nitroprop-2-enoate	Investigative	137653786	C19H19N3O4	353.4	CCN1C2=C(C=C(C=C2)N/C=C(/C(=O)OCC)\\[N+](=O)[O-])C3=CC=CC=C31	IC50 ~ 100000 nM	Poor binder
T61400	Dihydroorotate dehydrogenase	B6Z2GQ	(5-Methyl-4-phenyl-1H-pyrazol-3-yl)-(4-trifluoromethyl-phenyl)-amine	Investigative	10805428	C17H14F3N3	317.31	CC1=C(C(=NN1)NC2=CC=C(C=C2)C(F)(F)F)C3=CC=CC=C3	IC50 ~ 50000 nM	Poor binder
T61400	Dihydroorotate dehydrogenase	B7K2HI	N-[3-Fluoro-4-(trifluoromethyl)phenyl]-5-methyl-[1,2,4]triazolo[1,5-a]pyrimidin-7-amine	Investigative	25263434	C13H9F4N5	311.24	CC1=NC2=NC=NN2C(=C1)NC3=CC(=C(C=C3)C(F)(F)F)F	IC50 ~ 100000 nM	Poor binder
T61400	Dihydroorotate dehydrogenase	B7LJK9	5-Tert-Butyl-isoxazole-4-carbothioic acid (4-dimethylamino-phenyl)-amide	Investigative	44310382	C16H21N3OS	303.4	CC(C)(C)C1=C(C=NO1)C(=S)NC2=CC=C(C=C2)N(C)C	IC50 ~ 50000 nM	Poor binder
T61400	Dihydroorotate dehydrogenase	B7ORG2	N-(4-Chloro-3-fluorophenyl)-5-methyl-[1,2,4]triazolo[1,5-a]pyrimidin-7-amine	Investigative	51347852	C12H9ClFN5	277.68	CC1=NC2=NC=NN2C(=C1)NC3=CC(=C(C=C3)Cl)F	IC50 ~ 50000 nM	Poor binder
T61400	Dihydroorotate dehydrogenase	B7QCD1	5-Tert-Butyl-isoxazole-4-carbothioic acid (4-trifluoromethyl-phenyl)-amide	Investigative	44310352	C15H15F3N2OS	328.4	CC(C)(C)C1=C(C=NO1)C(=S)NC2=CC=C(C=C2)C(F)(F)F	IC50 ~ 50000 nM	Poor binder
T61400	Dihydroorotate dehydrogenase	B7ROD9	5-Phenyl-3-(4-trifluoromethyl-phenylamino)-1H-pyrazole-4-carbonitrile	Investigative	10496492	C17H11F3N4	328.29	C1=CC=C(C=C1)C2=C(C(=NN2)NC3=CC=C(C=C3)C(F)(F)F)C#N	IC50 ~ 50000 nM	Poor binder
T61400	Dihydroorotate dehydrogenase	B7TK8H	N-(4-Butylphenyl)-5-methyl-[1,2,4]triazolo[1,5-a]pyrimidin-7-amine	Investigative	44131922	C16H19N5	281.36	CCCCC1=CC=C(C=C1)NC2=CC(=NC3=NC=NN23)C	IC50 ~ 100000 nM	Poor binder
T61400	Dihydroorotate dehydrogenase	B7XK9S	N-(4-Chlorophenyl)-5-methyl-[1,2,4]triazolo[1,5-a]pyrimidin-7-amine	Investigative	741601	C12H10ClN5	259.69	CC1=NC2=NC=NN2C(=C1)NC3=CC=C(C=C3)Cl	IC50 ~ 100000 nM	Poor binder
T61400	Dihydroorotate dehydrogenase	B7XV1P	5-Methyl-isoxazole-4-carbothioic acid (4-dimethylamino-phenyl)-amide	Investigative	44310375	C13H15N3OS	261.339	CC1=C(C=NO1)C(=S)NC2=CC=C(C=C2)N(C)C	IC50 ~ 50000 nM	Poor binder
T61400	Dihydroorotate dehydrogenase	B8A7XY	N-(4-Ethynylphenyl)-5-methyl-[1,2,4]triazolo[1,5-a]pyrimidin-7-amine	Investigative	44133775	C14H11N5	249.27	CC1=NC2=NC=NN2C(=C1)NC3=CC=C(C=C3)C#C	IC50 ~ 100000 nM	Poor binder
T61400	Dihydroorotate dehydrogenase	B8H9ER	5-Methyl-N-[4-(trifluoromethylsulfanyl)phenyl]-[1,2,4]triazolo[1,5-a]pyrimidin-7-amine	Investigative	51347246	C13H10F3N5S	325.31	CC1=NC2=NC=NN2C(=C1)NC3=CC=C(C=C3)SC(F)(F)F	IC50 ~ 50000 nM	Poor binder
T61400	Dihydroorotate dehydrogenase	B8O5BW	8-Chloro-2-(4-chlorophenyl)-3-hydroxyquinoline-4-carboxylicacid	Investigative	16100003	C16H9Cl2NO3	334.1	C1=CC2=C(C(=C(N=C2C(=C1)Cl)C3=CC=C(C=C3)Cl)O)C(=O)O	IC50 = 141000 nM	Poor binder
T61400	Dihydroorotate dehydrogenase	B8PO0Y	2-Aminoethanol;5-[4-(2-methoxycarbonylphenyl)butyl]-2,4-dioxo-1H-pyrimidine-6-carboxylic acid	Investigative	134144166	C19H25N3O7	407.4	COC(=O)C1=CC=CC=C1CCCCC2=C(NC(=O)NC2=O)C(=O)O.C(CO)N	Ki = 102000 nM	Poor binder
T61400	Dihydroorotate dehydrogenase	B8Q0HD	3-(3-Bromo-4-trifluoromethyl-phenylamino)-5-methyl-1H-pyrazole-4-carbonitrile	Investigative	10759927	C12H8BrF3N4	345.12	CC1=C(C(=NN1)NC2=CC(=C(C=C2)C(F)(F)F)Br)C#N	IC50 ~ 50000 nM	Poor binder
T61400	Dihydroorotate dehydrogenase	B8XCM5	(Z)-N-[4-(3-Chlorophenyl)-2-(trifluoromethyl)phenyl]-2-cyano-3-hydroxybut-2-enamide	Investigative	54727979	C18H12ClF3N2O2	380.7	C/C(=C(\\C#N)/C(=O)NC1=C(C=C(C=C1)C2=CC(=CC=C2)Cl)C(F)(F)F)/O	IC50 = 86600 nM	Poor binder
T61400	Dihydroorotate dehydrogenase	B91VOM	5-(Trifluoromethyl)-N-(4-trifluoromethyl)phenyl)-[1,2,4]triazolo[1,5-a]pyrimidin-7-amine	Investigative	51347393	C13H7F6N5	347.22	C1=CC(=CC=C1C(F)(F)F)NC2=CC(=NC3=NC=NN23)C(F)(F)F	IC50 ~ 100000 nM	Poor binder
T61400	Dihydroorotate dehydrogenase	B93EZS	5-Chloro-N-(4-trifluoromethyl)phenyl)-[1,2,4]triazolo[1,5-a]pyrimidin-7-amine	Investigative	54585315	C12H7ClF3N5	313.66	C1=CC(=CC=C1C(F)(F)F)NC2=CC(=NC3=NC=NN23)Cl	IC50 ~ 100000 nM	Poor binder
T61400	Dihydroorotate dehydrogenase	B95NPG	5-Ethylamino-3-(4-trifluoromethyl-phenylamino)-1H-pyrazole-4-carbonitrile	Investigative	10565785	C13H12F3N5	295.26	CCNC1=NNC(=C1C#N)NC2=CC=C(C=C2)C(F)(F)F	IC50 ~ 50000 nM	Poor binder
T61400	Dihydroorotate dehydrogenase	B95PJO	Dsm-265	Investigative	51347395	C14H12F7N5S	415.33	CC1=NC2=NC(=NN2C(=C1)NC3=CC=C(C=C3)S(F)(F)(F)(F)F)C(C)(F)F	IC50 ~ 100000 nM	Poor binder
T61400	Dihydroorotate dehydrogenase	B9NTC8	2-(4-Chlorophenyl)-3-hydroxy-6-(thiophen-3-yl)quinoline-4-carboxylic acid	Investigative	16100002	C20H12ClNO3S	381.8	C1=CC(=CC=C1C2=NC3=C(C=C(C=C3)C4=CSC=C4)C(=C2O)C(=O)O)Cl	IC50 = 134000 nM	Poor binder
T61400	Dihydroorotate dehydrogenase	B9UD6E	2-Cyclopropyl-5-methyl-N-[4-(pentafluoro-$l^{6}-sulfanyl)phenyl]-[1,2,4]triazolo[1,5-a]pyrimidin-7-amine	Investigative	51347546	C15H14F5N5S	391.4	CC1=NC2=NC(=NN2C(=C1)NC3=CC=C(C=C3)S(F)(F)(F)(F)F)C4CC4	IC50 ~ 100000 nM	Poor binder
T61400	Dihydroorotate dehydrogenase	BA0KQ1	5-Methyl-3-(4-trifluoromethyl-benzylamino)-1H-pyrazole-4-carbonitrile	Investigative	10755169	C13H11F3N4	280.25	CC1=C(C(=NN1)NCC2=CC=C(C=C2)C(F)(F)F)C#N	IC50 ~ 50000 nM	Poor binder
T61400	Dihydroorotate dehydrogenase	BA3K1B	N-(4-Bromophenyl)-5-methyl-[1,2,4]triazolo[1,5-a]pyrimidin-7-amine	Investigative	517728	C12H10BrN5	304.15	CC1=NC2=NC=NN2C(=C1)NC3=CC=C(C=C3)Br	IC50 ~ 100000 nM	Poor binder
T61400	Dihydroorotate dehydrogenase	BA5UH2	2-Ethoxy-5-methyl-N-[4-(pentafluoro-$l^{6}-sulfanyl)phenyl]-[1,2,4]triazolo[1,5-a]pyrimidin-7-amine	Investigative	51347396	C14H14F5N5OS	395.35	CCOC1=NN2C(=CC(=NC2=N1)C)NC3=CC=C(C=C3)S(F)(F)(F)(F)F	IC50 ~ 100000 nM	Poor binder
T61400	Dihydroorotate dehydrogenase	BA7CL9	2-Benzylsulfanyl-5-methyl-[1,2,4]triazolo[1,5-a]pyrimidin-7-ol	Investigative	1965647	C13H12N4OS	272.33	CC1=CC(=O)N2C(=N1)N=C(N2)SCC3=CC=CC=C3	IC50 = 89000 nM	Poor binder
T61400	Dihydroorotate dehydrogenase	BA81LJ	5-Methyl-N-(4-vinylphenyl)-[1,2,4]triazolo[1,5-a]pyrimidin-7-amine	Investigative	44131574	C14H13N5	251.29	CC1=NC2=NC=NN2C(=C1)NC3=CC=C(C=C3)C=C	IC50 ~ 100000 nM	Poor binder
T61400	Dihydroorotate dehydrogenase	BAW1H2	5-Pyridin-3-yl-3-(4-trifluoromethyl-phenylamino)-1H-pyrazole-4-carbonitrile	Investigative	10544308	C16H10F3N5	329.28	C1=CC(=CN=C1)C2=C(C(=NN2)NC3=CC=C(C=C3)C(F)(F)F)C#N	IC50 ~ 50000 nM	Poor binder
T61400	Dihydroorotate dehydrogenase	BB0ME5	3-Carbamoyl-5-[3-[4-(trifluoromethyl)phenyl]phenyl]benzoic Acid	Investigative	10643787	C21H14F3NO3	385.3	C1=CC(=CC(=C1)C2=CC(=CC(=C2)C(=O)O)C(=O)N)C3=CC=C(C=C3)C(F)(F)F	Ki = 90000 nM	Poor binder
T61400	Dihydroorotate dehydrogenase	BB6W3T	1-(4-Methoxyphenyl)-3-N-(oxolan-2-ylmethyl)-5-N-[4-(pyrrolidine-1-carbonyl)phenyl]pyrazole-3,5-dicarboxamide	Investigative	10929378	C28H31N5O5	517.6	COC1=CC=C(C=C1)N2C(=CC(=N2)C(=O)NCC3CCCO3)C(=O)NC4=CC=C(C=C4)C(=O)N5CCCC5	Ki ~ 50000 nM	Poor binder
T61400	Dihydroorotate dehydrogenase	BB7F8D	2-Ethyl-5-methyl-N-[4-(trifluoromethyl)phenyl]-[1,2,4]triazolo[1,5-a]pyrimidin-7-amine	Investigative	44133588	C15H14F3N5	321.3	CCC1=NN2C(=CC(=NC2=N1)C)NC3=CC=C(C=C3)C(F)(F)F	IC50 ~ 100000 nM	Poor binder
T61400	Dihydroorotate dehydrogenase	BC4M9E	2-Cyclopropyl-5-methyl-N-[4-(trifluoromethyl)phenyl]-[1,2,4]triazolo[1,5-a]pyrimidin-7-amine	Investigative	51347692	C16H14F3N5	333.31	CC1=NC2=NC(=NN2C(=C1)NC3=CC=C(C=C3)C(F)(F)F)C4CC4	IC50 ~ 100000 nM	Poor binder
T61400	Dihydroorotate dehydrogenase	BCL27P	2-Ethoxy-5-methyl-N-[4-(trifluoromethyl)phenyl]-[1,2,4]triazolo[1,5-a]pyrimidin-7-amine	Investigative	44133769	C15H14F3N5O	337.3	CCOC1=NN2C(=CC(=NC2=N1)C)NC3=CC=C(C=C3)C(F)(F)F	IC50 ~ 100000 nM	Poor binder
T61400	Dihydroorotate dehydrogenase	BCR3K4	N-(3,4-Dimethylphenyl)-5-methyl-[1,2,4]triazolo[1,5-a]pyrimidin-7-amine	Investigative	777184	C14H15N5	253.3	CC1=C(C=C(C=C1)NC2=CC(=NC3=NC=NN23)C)C	IC50 ~ 100000 nM	Poor binder
T61400	Dihydroorotate dehydrogenase	BD2FM8	N-(4-Cyclopropylphenyl)-5-methyl-[1,2,4]triazolo[1,5-a]pyrimidin-7-amine	Investigative	51347695	C15H15N5	265.31	CC1=NC2=NC=NN2C(=C1)NC3=CC=C(C=C3)C4CC4	IC50 ~ 100000 nM	Poor binder
T61400	Dihydroorotate dehydrogenase	BD4K2H	CID 53392883	Investigative	53392883	C14H14ClN5O	303.75	CCOC1=NN2C(=CC(=NC2=N1)C)NC3=CC(=CC=C3)Cl	IC50 ~ 100000 nM	Poor binder
T61400	Dihydroorotate dehydrogenase	BD8X5W	3-N-Benzyl-1-(4-chlorophenyl)-5-N-phenylpyrazole-3,5-dicarboxamide	Investigative	9824035	C24H19ClN4O2	430.9	C1=CC=C(C=C1)CNC(=O)C2=NN(C(=C2)C(=O)NC3=CC=CC=C3)C4=CC=C(C=C4)Cl	Ki = 50000 nM	Poor binder
T61400	Dihydroorotate dehydrogenase	BDC39A	2-Aminoethanol;5-[2-(4-fluoro-3-methylphenyl)ethyl]-2,4-dioxo-1H-pyrimidine-6-carboxylic acid	Investigative	134132411	C16H20FN3O5	353.35	CC1=C(C=CC(=C1)CCC2=C(NC(=O)NC2=O)C(=O)O)F.C(CO)N	Ki = 147000 nM	Poor binder
T61400	Dihydroorotate dehydrogenase	BDK2L0	Diethyl [(1h-indazol-5-ylamino)methylidene]propanedioate	Investigative	12454047	C15H17N3O4	303.31	CCOC(=O)C(=CNC1=CC2=C(C=C1)NN=C2)C(=O)OCC	IC50 = 123300 nM	Poor binder
T61400	Dihydroorotate dehydrogenase	BDP63J	5-Tert-Butyl-3-(4-trifluoromethyl-phenylamino)-1H-pyrazole-4-carbonitrile	Investigative	10828593	C15H15F3N4	308.3	CC(C)(C)C1=C(C(=NN1)NC2=CC=C(C=C2)C(F)(F)F)C#N	IC50 ~ 50000 nM	Poor binder
T61400	Dihydroorotate dehydrogenase	BE36ZW	5-Hexyl-isoxazole-4-carbothioic acid (4-dimethylamino-phenyl)-amide	Investigative	44310719	C18H25N3OS	331.5	CCCCCCC1=C(C=NO1)C(=S)NC2=CC=C(C=C2)N(C)C	IC50 ~ 50000 nM	Poor binder
T61400	Dihydroorotate dehydrogenase	BE5SK4	5-Tert-Butyl-isoxazole-4-carbothioic acid (4-trifluoromethoxy-phenyl)-amide	Investigative	44310351	C15H15F3N2O2S	344.4	CC(C)(C)C1=C(C=NO1)C(=S)NC2=CC=C(C=C2)OC(F)(F)F	IC50 ~ 50000 nM	Poor binder
T61400	Dihydroorotate dehydrogenase	BEP5C6	2-[4-(4-Acetamidophenyl)phenyl]-1H-benzimidazole-4-carboxamide	Investigative	122182314	C22H18N4O2	370.4	CC(=O)NC1=CC=C(C=C1)C2=CC=C(C=C2)C3=NC4=C(C=CC=C4N3)C(=O)N	IC50 = 56000 nM	Poor binder
T61400	Dihydroorotate dehydrogenase	BF1H0O	2-(1,1-Difluoroethyl)-5-Methyl-N-[4-(Trifluoromethyl)phenyl][1,2,4]triazolo[1,5-A]pyrimidin-7-Amine	Investigative	51349276	C15H12F5N5	357.28	CC1=NC2=NC(=NN2C(=C1)NC3=CC=C(C=C3)C(F)(F)F)C(C)(F)F	IC50 ~ 100000 nM	Poor binder
T61400	Dihydroorotate dehydrogenase	BF1WX2	5-Hydroxy-3-(4-trifluoromethyl-phenylamino)-1H-pyrazole-4-carbonitrile	Investigative	10587934	C11H7F3N4O	268.19	C1=CC(=CC=C1C(F)(F)F)NC2=C(C(=O)NN2)C#N	IC50 ~ 50000 nM	Poor binder
T61400	Dihydroorotate dehydrogenase	BF6CH8	1-(4-Chlorophenyl)-5-N-(4-piperidin-1-ylphenyl)-3-N-(pyridin-3-ylmethyl)pyrazole-3,5-dicarboxamide	Investigative	11016730	C28H27ClN6O2	515	C1CCN(CC1)C2=CC=C(C=C2)NC(=O)C3=CC(=NN3C4=CC=C(C=C4)Cl)C(=O)NCC5=CN=CC=C5	Ki ~ 50000 nM	Poor binder
T61400	Dihydroorotate dehydrogenase	BF6Z7I	2-(4-Bromophenyl)-3-hydroxy-7,8-dimethylquinoline-4-carboxylicacid	Investigative	16099913	C18H14BrNO3	372.2	CC1=C(C2=NC(=C(C(=C2C=C1)C(=O)O)O)C3=CC=C(C=C3)Br)C	IC50 = 56000 nM	Poor binder
T61400	Dihydroorotate dehydrogenase	BFBZ86	5-Hexyl-isoxazole-4-carbothioic acid (4-trifluoromethoxy-phenyl)-amide	Investigative	44310364	C17H19F3N2O2S	372.4	CCCCCCC1=C(C=NO1)C(=S)NC2=CC=C(C=C2)OC(F)(F)F	IC50 ~ 50000 nM	Poor binder
T61400	Dihydroorotate dehydrogenase	BFE62M	N-(2,3-Dihydro-1H-inden-5-yl)-5-methyl-[1,2,4]triazolo[1,5-a]pyrimidin-7-amine	Investigative	3227262	C15H15N5	265.31	CC1=NC2=NC=NN2C(=C1)NC3=CC4=C(CCC4)C=C3	IC50 ~ 100000 nM	Poor binder
T61400	Dihydroorotate dehydrogenase	BG52FX	CID 53392704	Investigative	53392704	C15H14ClF2N5	337.75	CCC(C1=NN2C(=CC(=NC2=N1)C)NC3=CC=C(C=C3)Cl)(F)F	IC50 ~ 100000 nM	Poor binder
T61400	Dihydroorotate dehydrogenase	BGC18W	Diethyl 2-(4-toluidinomethylene)malonate	Investigative	3851642	C15H19NO4	277.31	CCOC(=O)C(=CNC1=CC=C(C=C1)C)C(=O)OCC	IC50 = 145700 nM	Poor binder
T61400	Dihydroorotate dehydrogenase	BGV91I	5-Cyclohexyl-isoxazole-4-carbothioic acid (4-trifluoromethoxy-phenyl)-amide	Investigative	44310718	C17H17F3N2O2S	370.4	C1CCC(CC1)C2=C(C=NO2)C(=S)NC3=CC=C(C=C3)OC(F)(F)F	IC50 ~ 50000 nM	Poor binder
T61400	Dihydroorotate dehydrogenase	BHAN56	CID 53392619	Investigative	53392619	C15H14ClN5	299.76	CC1=NC2=NC(=NN2C(=C1)NC3=CC=C(C=C3)Cl)C4CC4	IC50 ~ 100000 nM	Poor binder
T61400	Dihydroorotate dehydrogenase	BHK56O	2-Aminoethanol;2,4-dioxo-5-[2-[3-(trifluoromethyl)phenyl]ethyl]-1H-pyrimidine-6-carboxylic acid	Investigative	134134172	C16H18F3N3O5	389.33	C1=CC(=CC(=C1)C(F)(F)F)CCC2=C(NC(=O)NC2=O)C(=O)O.C(CO)N	Ki = 142000 nM	Poor binder
T61400	Dihydroorotate dehydrogenase	BHU3M1	5-Amino-3-(4-trifluoromethyl-phenylamino)-1H-pyrazole-4-carbonitrile	Investigative	10515945	C11H8F3N5	267.21	C1=CC(=CC=C1C(F)(F)F)NC2=NNC(=C2C#N)N	IC50 ~ 50000 nM	Poor binder
T61400	Dihydroorotate dehydrogenase	BKET78	N-(3-Fluoro-4-methylphenyl)-6,7-dihydro-5H-cyclopenta[d][1,2,4]triazolo[1,5-a]pyrimidin-8-amine	Investigative	22579221	C15H14FN5	283.3	CC1=C(C=C(C=C1)NC2=C3CCCC3=NC4=NC=NN24)F	IC50 ~ 100000 nM	Poor binder
T61400	Dihydroorotate dehydrogenase	BKRM90	3-[(4-Aminophenyl)amino]-5-methyl-1H-pyrazole-4-carbonitrile	Investigative	10703799	C11H11N5	213.24	CC1=C(C(=NN1)NC2=CC=C(C=C2)N)C#N	IC50 ~ 50000 nM	Poor binder
T61400	Dihydroorotate dehydrogenase	BKW6V5	Ethyl 2-[(4-chlorophenyl)amino]-4-oxo-4,5-dihydrothiophene-3-carboxylate	Investigative	135449276	C13H12ClNO3S	297.76	CCOC(=O)C1=C(CSC1=NC2=CC=C(C=C2)Cl)O	IC50 ~ 50000 nM	Poor binder
T61400	Dihydroorotate dehydrogenase	BKYN37	CID 53392884	Investigative	53392884	C14H14ClN5O	303.75	CCOC1=NN2C(=CC(=NC2=N1)C)NC3=CC=C(C=C3)Cl	IC50 ~ 100000 nM	Poor binder
T61400	Dihydroorotate dehydrogenase	BM3E1B	5-Methyl-6-propyl-N-p-tolyl-[1,2,4]triazolo[1,5-a]pyrimidin-7-amine	Investigative	22433941	C16H19N5	281.36	CCCC1=C(N2C(=NC=N2)N=C1C)NC3=CC=C(C=C3)C	IC50 ~ 100000 nM	Poor binder
T61400	Dihydroorotate dehydrogenase	BM4DU9	2-Aminoethanol;5-[2-[6-(methoxymethoxy)naphthalen-2-yl]ethyl]-2,4-dioxo-1H-pyrimidine-6-carboxylic acid	Investigative	134142713	C21H25N3O7	431.4	COCOC1=CC2=C(C=C1)C=C(C=C2)CCC3=C(NC(=O)NC3=O)C(=O)O.C(CO)N	Ki = 139000 nM	Poor binder
T61400	Dihydroorotate dehydrogenase	BM6G8F	2-(4-Chlorophenyl)-3-hydroxy-7-methoxyquinoline-4-carboxylate	Investigative	16099900	C17H12ClNO4	329.7	COC1=CC2=C(C=C1)C(=C(C(=N2)C3=CC=C(C=C3)Cl)O)C(=O)O	IC50 = 151000 nM	Poor binder
T61400	Dihydroorotate dehydrogenase	BM71GN	2-[(3,4-Dichlorophenyl)methylsulfanyl]-5-methyl-[1,2,4]triazolo[1,5-a]pyrimidin-7-amine	Investigative	60166619	C13H11Cl2N5S	340.2	CC1=NC2=NC(=NN2C(=C1)N)SCC3=CC(=C(C=C3)Cl)Cl	IC50 ~ 100000 nM	Poor binder
T61400	Dihydroorotate dehydrogenase	BMFI92	6-Ethyl-N-(4-isopropylphenyl)-5-methyl-[1,2,4]triazolo[1,5-a]pyrimidin-7-amine	Investigative	22577320	C17H21N5	295.4	CCC1=C(N2C(=NC=N2)N=C1C)NC3=CC=C(C=C3)C(C)C	IC50 ~ 100000 nM	Poor binder
T61400	Dihydroorotate dehydrogenase	BMN8Y5	5-Furan-2-yl-3-(4-trifluoromethyl-phenylamino)-1H-pyrazole-4-carbonitrile	Investigative	10829333	C15H9F3N4O	318.25	C1=COC(=C1)C2=C(C(=NN2)NC3=CC=C(C=C3)C(F)(F)F)C#N	IC50 ~ 50000 nM	Poor binder
T61400	Dihydroorotate dehydrogenase	BMS58Y	N-[4-Bromo-3-(trifluoromethyl)phenyl]-5-methyl-[1,2,4]triazolo[1,5-a]pyrimidin-7-amine	Investigative	25263431	C13H9BrF3N5	372.14	CC1=NC2=NC=NN2C(=C1)NC3=CC(=C(C=C3)Br)C(F)(F)F	IC50 ~ 100000 nM	Poor binder
T61400	Dihydroorotate dehydrogenase	BN03TL	CID 53392620	Investigative	53392620	C15H14ClN5	299.76	CC1=NC2=NC(=NN2C(=C1)NC3=CC(=CC=C3)Cl)C4CC4	IC50 ~ 100000 nM	Poor binder
T61400	Dihydroorotate dehydrogenase	BN5SQ4	2-Ethyl-5-methyl-N-[4-(pentafluoro-$l^{6}-sulfanyl)phenyl]-[1,2,4]triazolo[1,5-a]pyrimidin-7-amine	Investigative	51347397	C14H14F5N5S	379.35	CCC1=NN2C(=CC(=NC2=N1)C)NC3=CC=C(C=C3)S(F)(F)(F)(F)F	IC50 ~ 100000 nM	Poor binder
T61400	Dihydroorotate dehydrogenase	BN90UX	5-Thiophen-2-yl-3-(4-trifluoromethyl-phenylamino)-1H-pyrazole-4-carbonitrile	Investigative	10759123	C15H9F3N4S	334.3	C1=CSC(=C1)C2=C(C(=NN2)NC3=CC=C(C=C3)C(F)(F)F)C#N	IC50 ~ 50000 nM	Poor binder
T61400	Dihydroorotate dehydrogenase	BNF9D2	5-Methyl-3-(2-trifluoromethyl-phenylamino)-1H-pyrazole-4-carbonitrile	Investigative	10587807	C12H9F3N4	266.22	CC1=C(C(=NN1)NC2=CC=CC=C2C(F)(F)F)C#N	IC50 ~ 50000 nM	Poor binder
T61400	Dihydroorotate dehydrogenase	BNT21G	5-Ethyl-N-(4-trifluoromethyl)phenyl-[1,2,4]triazolo[1,5-a]pyrimidin-7-amine	Investigative	53259245	C14H12F3N5	307.27	CCC1=NC2=NC=NN2C(=C1)NC3=CC=C(C=C3)C(F)(F)F	IC50 ~ 100000 nM	Poor binder
T61400	Dihydroorotate dehydrogenase	BPEI71	5-Methyl-2-(trifluoromethyl)-N-[4-(trifluoromethyl)phenyl]-[1,2,4]triazolo[1,5-a]pyrimidin-7-amine	Investigative	51347103	C14H9F6N5	361.24	CC1=NC2=NC(=NN2C(=C1)NC3=CC=C(C=C3)C(F)(F)F)C(F)(F)F	IC50 ~ 100000 nM	Poor binder
T61400	Dihydroorotate dehydrogenase	BPWK91	N-(5-Bromoindan-2-yl)-5-methyl-[1,2,4]triazolo[1,5-a]pyrimidin-7-amine	Investigative	51347391	C15H14BrN5	344.21	CC1=NC2=NC=NN2C(=C1)NC3CC4=C(C3)C=C(C=C4)Br	IC50 ~ 50000 nM	Poor binder
T61400	Dihydroorotate dehydrogenase	BPX64T	2-(4-Chlorophenyl)-3-hydroxy-8-trifluoromethylquinoline-4-carboxylic acid	Investigative	16099914	C17H9ClF3NO3	367.7	C1=CC2=C(C(=C(N=C2C(=C1)C(F)(F)F)C3=CC=C(C=C3)Cl)O)C(=O)O	IC50 = 136000 nM	Poor binder
T61400	Dihydroorotate dehydrogenase	BQ9Y2G	3-Carbamoyl-5-[3-(3-methylphenyl)phenyl]benzoic Acid	Investigative	10687946	C21H17NO3	331.4	CC1=CC(=CC=C1)C2=CC(=CC=C2)C3=CC(=CC(=C3)C(=O)O)C(=O)N	Ki = 50000 nM	Poor binder
T61400	Dihydroorotate dehydrogenase	BQB25W	N-(5-Fluoroindan-2-yl)-5-methyl-[1,2,4]triazolo[1,5-a]pyrimidin-7-amine	Investigative	51347247	C15H14FN5	283.3	CC1=NC2=NC=NN2C(=C1)NC3CC4=C(C3)C=C(C=C4)F	IC50 ~ 50000 nM	Poor binder
T61400	Dihydroorotate dehydrogenase	BQV67L	5-Tert-Butyl-isoxazole-4-carbothioic acid (4-cyano-phenyl)-amide	Investigative	44310365	C15H15N3OS	285.4	CC(C)(C)C1=C(C=NO1)C(=S)NC2=CC=C(C=C2)C#N	IC50 ~ 50000 nM	Poor binder
T61400	Dihydroorotate dehydrogenase	BR5A0I	8-Bromo-2-(4-chlorophenyl)-3-hydroxyquinoline-4-carboxylicacid	Investigative	16100006	C16H9BrClNO3	378.6	C1=CC2=C(C(=C(N=C2C(=C1)Br)C3=CC=C(C=C3)Cl)O)C(=O)O	IC50 = 132000 nM	Poor binder
T61400	Dihydroorotate dehydrogenase	BRB87Q	5-Cyclohexyl-isoxazole-4-carbothioic acid (4-cyano-phenyl)-amide	Investigative	44310717	C17H17N3OS	311.4	C1CCC(CC1)C2=C(C=NO2)C(=S)NC3=CC=C(C=C3)C#N	IC50 ~ 50000 nM	Poor binder
T61400	Dihydroorotate dehydrogenase	BRD50U	N-(4-Chlorophenyl)-2-(1,1-difluoroethyl)-5-methyl-[1,2,4]triazolo[1,5-a]pyrimidin-7-amine	Investigative	51347101	C14H12ClF2N5	323.73	CC1=NC2=NC(=NN2C(=C1)NC3=CC=C(C=C3)Cl)C(C)(F)F	IC50 ~ 100000 nM	Poor binder
T61400	Dihydroorotate dehydrogenase	BRH7D4	N-(3-Fluoro-4-methylphenyl)-5-methyl-[1,2,4]triazolo[1,5-a]pyrimidin-7-amine	Investigative	653193	C13H12FN5	257.269	CC1=C(C=C(C=C1)NC2=CC(=NC3=NC=NN23)C)F	IC50 ~ 100000 nM	Poor binder
T61400	Dihydroorotate dehydrogenase	BRO54K	2-Aminoethanol;5-[2-[5-(methylcarbamoyl)naphthalen-2-yl]ethyl]-2,4-dioxo-1H-pyrimidine-6-carboxylic acid	Investigative	134146963	C21H24N4O6	428.4	CNC(=O)C1=CC=CC2=C1C=CC(=C2)CCC3=C(NC(=O)NC3=O)C(=O)O.C(CO)N	Ki = 149000 nM	Poor binder
T61400	Dihydroorotate dehydrogenase	BRTD90	2-Aminoethanol;5-[2-[1-[(2-methylpropan-2-yl)oxycarbonyl]-2,3-dihydroindol-5-yl]ethyl]-2,4-dioxo-1H-pyrimidine-6-carboxylic acid	Investigative	134151955	C22H30N4O7	462.5	CC(C)(C)OC(=O)N1CCC2=C1C=CC(=C2)CCC3=C(NC(=O)NC3=O)C(=O)O.C(CO)N	Ki = 195000 nM	Poor binder
T61400	Dihydroorotate dehydrogenase	BRX9S1	2-Butan-2-yl-5-methyl-N-[4-(pentafluoro-lambda6-sulfanyl)phenyl]-[1,2,4]triazolo[1,5-a]pyrimidin-7-amine	Investigative	53392618	C16H18F5N5S	407.4	CCC(C)C1=NN2C(=CC(=NC2=N1)C)NC3=CC=C(C=C3)S(F)(F)(F)(F)F	IC50 ~ 100000 nM	Poor binder
T61400	Dihydroorotate dehydrogenase	BSDA92	N-(5-Methyl-[1,2,4]triazolo[1,5-a]pyrimidin-7-yl)-4-(trifluoromethyl)benzamide	Investigative	71460750	C14H10F3N5O	321.26	CC1=NC2=NC=NN2C(=C1)NC(=O)C3=CC=C(C=C3)C(F)(F)F	IC50 ~ 100000 nM	Poor binder
T61400	Dihydroorotate dehydrogenase	BSV2B0	5-Methyl-3-phenylamino-1H-pyrazole-4-carbonitrile	Investigative	10488180	C11H10N4	198.22	CC1=C(C(=NN1)NC2=CC=CC=C2)C#N	IC50 ~ 50000 nM	Poor binder
T61400	Dihydroorotate dehydrogenase	BSWL16	5-Methyl-N-[4-(trifluoromethoxy)phenyl]-[1,2,4]triazolo[1,5-a]pyrimidin-7-amine	Investigative	1460771	C13H10F3N5O	309.25	CC1=NC2=NC=NN2C(=C1)NC3=CC=C(C=C3)OC(F)(F)F	IC50 ~ 100000 nM	Poor binder
T61400	Dihydroorotate dehydrogenase	BT0KH2	5-Cyclopentyl-3-(4-trifluoromethyl-phenylamino)-1H-pyrazole-4-carbonitrile	Investigative	10519719	C16H15F3N4	320.31	C1CCC(C1)C2=C(C(=NN2)NC3=CC=C(C=C3)C(F)(F)F)C#N	IC50 ~ 50000 nM	Poor binder
T61400	Dihydroorotate dehydrogenase	BT3VI0	5-Methyl-3-(3-trifluoromethyl-phenylamino)-1H-pyrazole-4-carbonitrile	Investigative	10849345	C12H9F3N4	266.22	CC1=C(C(=NN1)NC2=CC=CC(=C2)C(F)(F)F)C#N	IC50 ~ 50000 nM	Poor binder
T61400	Dihydroorotate dehydrogenase	BTC69H	5-Cyclohexyl-isoxazole-4-carbothioic acid (4-trifluoromethyl-phenyl)-amide	Investigative	44310695	C17H17F3N2OS	354.4	C1CCC(CC1)C2=C(C=NO2)C(=S)NC3=CC=C(C=C3)C(F)(F)F	IC50 ~ 50000 nM	Poor binder
T61400	Dihydroorotate dehydrogenase	BTN82D	5-Methyl-N-(4-propylphenyl)-[1,2,4]triazolo[1,5-a]pyrimidin-7-amine	Investigative	32617117	C15H17N5	267.33	CCCC1=CC=C(C=C1)NC2=CC(=NC3=NC=NN23)C	IC50 ~ 100000 nM	Poor binder
T61400	Dihydroorotate dehydrogenase	BU0VL6	N-[3,5-Difluoro-4-(trifluoromethyl)phenyl]-5-methyl-[1,2,4]triazolo[1,5-a]pyrimidin-7-amine	Investigative	51347104	C13H8F5N5	329.23	CC1=NC2=NC=NN2C(=C1)NC3=CC(=C(C(=C3)F)C(F)(F)F)F	IC50 ~ 100000 nM	Poor binder
T61400	Dihydroorotate dehydrogenase	BUD5K7	5-Methyl-3-(4-trifluoromethyl-phenylamino)-1H-pyrazole-4-carboxylic acid ethyl ester	Investigative	10710291	C14H14F3N3O2	313.27	CCOC(=O)C1=C(NN=C1NC2=CC=C(C=C2)C(F)(F)F)C	IC50 ~ 50000 nM	Poor binder
T61400	Dihydroorotate dehydrogenase	BUQ6R9	2-Isopropyl-5-methyl-N-[4-(pentafluoro-$l^{6}-sulfanyl)phenyl]-[1,2,4]triazolo[1,5-a]pyrimidin-7-amine	Investigative	51347540	C15H16F5N5S	393.4	CC1=NC2=NC(=NN2C(=C1)NC3=CC=C(C=C3)S(F)(F)(F)(F)F)C(C)C	IC50 ~ 100000 nM	Poor binder
T61400	Dihydroorotate dehydrogenase	BV0O3J	1,3-Dimethyl-5-(4-trifluoromethyl-phenylamino)-1H-pyrazole-4-carbonitrile	Investigative	10492984	C13H11F3N4	280.25	CC1=NN(C(=C1C#N)NC2=CC=C(C=C2)C(F)(F)F)C	IC50 ~ 50000 nM	Poor binder
T61400	Dihydroorotate dehydrogenase	BV9RF8	N-(4-Pentafluorosulfenylphenyl)-5-methyl-[1,2,4]triazolo[1,5-a]pyrimidin-7-amine	Investigative	53257300	C12H10F5N5S	351.3	CC1=NC2=NC=NN2C(=C1)NC3=CC=C(C=C3)S(F)(F)(F)(F)F	IC50 ~ 100000 nM	Poor binder
T61400	Dihydroorotate dehydrogenase	BVA0R3	2-(4-Chlorophenyl)-3-hydroxy-5-methylquinoline-4-carboxylicacid	Investigative	16099918	C17H12ClNO3	313.7	CC1=C2C(=CC=C1)N=C(C(=C2C(=O)O)O)C3=CC=C(C=C3)Cl	IC50 = 51000 nM	Poor binder
T61400	Dihydroorotate dehydrogenase	BW3MQ5	1-(4-Chlorophenyl)-3-N-[(4-methylphenyl)methyl]-5-N-phenylpyrazole-3,5-dicarboxamide	Investigative	10895558	C25H21ClN4O2	444.9	CC1=CC=C(C=C1)CNC(=O)C2=NN(C(=C2)C(=O)NC3=CC=CC=C3)C4=CC=C(C=C4)Cl	Ki ~ 50000 nM	Poor binder
T61400	Dihydroorotate dehydrogenase	BW5RJ1	5-N-Benzyl-1-(4-methoxyphenyl)-3-N-[4-(pyrrolidine-1-carbonyl)phenyl]pyrazole-3,5-dicarboxamide	Investigative	11038663	C30H29N5O4	523.6	COC1=CC=C(C=C1)N2C(=CC(=N2)C(=O)NC3=CC=C(C=C3)C(=O)N4CCCC4)C(=O)NCC5=CC=CC=C5	Ki ~ 50000 nM	Poor binder
T61400	Dihydroorotate dehydrogenase	BW82OV	3-N-Benzyl-1-(4-chlorophenyl)-5-N-(2-methylpropyl)pyrazole-3,5-dicarboxamide	Investigative	11825758	C22H23ClN4O2	410.9	CC(C)CNC(=O)C1=CC(=NN1C2=CC=C(C=C2)Cl)C(=O)NCC3=CC=CC=C3	Ki ~ 50000 nM	Poor binder
T61400	Dihydroorotate dehydrogenase	BWC5U8	N-(3-Chlorophenyl)-5-methyl-[1,2,4]triazolo[1,5-a]pyrimidin-7-amine	Investigative	517858	C12H10ClN5	259.69	CC1=NC2=NC=NN2C(=C1)NC3=CC(=CC=C3)Cl	IC50 ~ 100000 nM	Poor binder
T61400	Dihydroorotate dehydrogenase	BWCO54	6-Ethyl-5-methyl-N-(4-(trifluoromethoxy)phenyl)-[1,2,4]triazolo[1,5-a]pyrimidin-7-amine	Investigative	46352384	C15H14F3N5O	337.3	CCC1=C(N2C(=NC=N2)N=C1C)NC3=CC=C(C=C3)OC(F)(F)F	IC50 ~ 100000 nM	Poor binder
T61400	Dihydroorotate dehydrogenase	BWX81V	CID 60166620	Investigative	60166620	C20H19N5S	361.5	CC1=NC2=NC(=NN2C(=C1)NCC3=CC=CC=C3)SCC4=CC=CC=C4	IC50 ~ 100000 nM	Poor binder
T61400	Dihydroorotate dehydrogenase	BX51HE	N,N-Dimethyl-N'-(5-methyl-[1,2,4]triazolo[1,5-a]pyrimidin-7-yl)-benzene-1,4-diamine	Investigative	741604	C14H16N6	268.32	CC1=NC2=NC=NN2C(=C1)NC3=CC=C(C=C3)N(C)C	IC50 ~ 100000 nM	Poor binder
T61400	Dihydroorotate dehydrogenase	BXB84M	3-N-Benzyl-5-N-(4-carbamoylphenyl)-1-(4-chlorophenyl)pyrazole-3,5-dicarboxamide	Investigative	11102808	C25H20ClN5O3	473.9	C1=CC=C(C=C1)CNC(=O)C2=NN(C(=C2)C(=O)NC3=CC=C(C=C3)C(=O)N)C4=CC=C(C=C4)Cl	Ki ~ 50000 nM	Poor binder
T61400	Dihydroorotate dehydrogenase	BXD98K	(2S,3S,4S)-3-(3',4'-Bis(trifluoromethyl)-[1,1'-biphenyl]-4-yl)-2-cyano-4-(hydroxymethyl)-N-propylazetidine-1-carboxamide	Investigative	121596187	C23H21F6N3O2	485.4	CCCNC(=O)N1[C@@H]([C@H]([C@H]1C#N)C2=CC=C(C=C2)C3=CC(=C(C=C3)C(F)(F)F)C(F)(F)F)CO	IC50 ~ 50000 nM	Poor binder
T61400	Dihydroorotate dehydrogenase	BXK7V2	Chembl4226738	Investigative	145967883	C23H15F3N2O2	408.4	COC(=O)C1=CC(=NC2=CC=CC=C21)C3=CC=C(C=C3)C4=C(C=CN=C4)C(F)(F)F	IC50 ~ 50000 nM	Poor binder
T61400	Dihydroorotate dehydrogenase	BY95JI	1-(4-Methoxyphenyl)-3-N-(2-methylpropyl)-5-N-[4-(pyrrolidine-1-carbonyl)phenyl]pyrazole-3,5-dicarboxamide	Investigative	11762691	C27H31N5O4	489.6	CC(C)CNC(=O)C1=NN(C(=C1)C(=O)NC2=CC=C(C=C2)C(=O)N3CCCC3)C4=CC=C(C=C4)OC	Ki ~ 50000 nM	Poor binder
T61400	Dihydroorotate dehydrogenase	BZ3O6P	2-Methyl-N-(2-naphthyl)-9H-purin-6-amine	Investigative	57825994	C16H13N5	275.31	CC1=NC2=C(C(=N1)NC3=CC4=CC=CC=C4C=C3)NC=N2	IC50 ~ 100000 nM	Poor binder
T61400	Dihydroorotate dehydrogenase	BZD30P	CID 53392705	Investigative	53392705	C15H14ClF2N5	337.75	CCC(C1=NN2C(=CC(=NC2=N1)C)NC3=CC(=CC=C3)Cl)(F)F	IC50 ~ 100000 nM	Poor binder
T61400	Dihydroorotate dehydrogenase	BZG0K5	N-(2,2-Diphenylethyl)-3,4-difluoro-2-hydroxybenzamide	Investigative	90665767	C21H17F2NO2	353.4	C1=CC=C(C=C1)C(CNC(=O)C2=C(C(=C(C=C2)F)F)O)C3=CC=CC=C3	IC50 = 130000 nM	Poor binder
T61400	Dihydroorotate dehydrogenase	D01NWQ	N-(4-bromo-2-methylphenyl)-2-naphthamide	Investigative	823850	C18H14BrNO	340.2	CC1=C(C=CC(=C1)Br)NC(=O)C2=CC3=CC=CC=C3C=C2	Ki = 50900 nM	Poor binder
T61400	Dihydroorotate dehydrogenase	D04FYN	Diethyl 2-((biphenyl-3-ylamino)methylene)malonate	Investigative	16102645	C20H21NO4	339.4	CCOC(=O)C(=CNC1=CC=CC(=C1)C2=CC=CC=C2)C(=O)OCC	IC50 = 104200 nM	Poor binder
T61400	Dihydroorotate dehydrogenase	D0C1NU	N-(3,5-dichlorophenyl)-2-methyl-3-nitrobenzamide	Investigative	799096	C14H10Cl2N2O3	325.1	CC1=C(C=CC=C1[N+](=O)[O-])C(=O)NC2=CC(=CC(=C2)Cl)Cl	Ki = 64400 nM	Poor binder