TTD_Target_ID	Target_Name	TTD_Drug_ID	Drug_Name	Drug_Highest_Status	Drug_PubchemID	Molecular_Formula	Molecular_Weight	Canonical_SMILES	Activity	Binder_Type
T61484	Chymotrypsin C	D0J2VB	Iboctadekin + rituximab	Phase 1	5478883	C34H63N5O9	685.9	C[C@@H](C(=O)N[C@@H](CC(C)C)[C@H](CC(=O)O)O)NC(=O)C[C@@H]([C@H](CC(C)C)NC(=O)[C@H](C(C)C)NC(=O)[C@H](C(C)C)NC(=O)CC(C)C)O	IC50 ~ 100000 nM	Poor binder
T61484	Chymotrypsin C	D0Y3DN	Flavonoid derivative 4	Patented	5280343	C15H10O7	302.23	C1=CC(=C(C=C1C2=C(C(=O)C3=C(C=C(C=C3O2)O)O)O)O)O	IC50 = 100000 nM	Poor binder
T61484	Chymotrypsinogen B	D0Y3DN	Flavonoid derivative 4	Patented	5280343	C15H10O7	302.23	C1=CC(=C(C=C1C2=C(C(=O)C3=C(C=C(C=C3O2)O)O)O)O)O	IC50 = 100000 nM	Poor binder
T61484	Chymotrypsin C	D0WY9H	ZD-0892	Discontinued in Phase 1	9892148	C24H32F3N3O5	499.5	CC(C)[C@@H](C(=O)C(F)(F)F)NC(=O)[C@@H]1CCCN1C(=O)[C@H](C(C)C)NC(=O)C2=CC=C(C=C2)OC	Ki = 200000 nM	Poor binder
T61484	Chymotrypsin C	D0V5XL	KRI-1314	Terminated	6918046	C38H51N5O7	689.8	CC(C)OC(=O)[C@@H]([C@H](CC1CCCCC1)NC(=O)[C@H](CC2=CN=CN2)NC(=O)[C@H](CC3=CC=CC4=CC=CC=C43)CC(=O)N5CCOCC5)O	IC50 ~ 100000 nM	Poor binder
T61484	Chymotrypsin C	B02GEN	(4S)-4-[[(2S)-2-Amino-3-carboxypropanoyl]amino]-5-[[(2S)-1-[[(2S)-1-[(2R)-2-[[(1R)-3-(4-tert-butylphenyl)-1-[(1S,2S,6R,8S)-2,9,9-trimethyl-3,5-dioxa-4-boratricyclo[6.1.1.02,6]decan-4-yl]propyl]carbamoyl]pyrrolidin-1-yl]-3-methyl-1-oxobutan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-5-oxopentanoic acid	Investigative	44338807	C47H73BN6O11	908.9	B1(O[C@@H]2C[C@@H]3C[C@H]([C@@]2(O1)C)C3(C)C)[C@H](CCC4=CC=C(C=C4)C(C)(C)C)NC(=O)[C@H]5CCCN5C(=O)[C@H](C(C)C)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(=O)O)N	IC50 ~ 60000 nM	Poor binder
T61484	Chymotrypsinogen B	B0EV4J	2-Oxo-4-phenacylsulfanyl-N-[(1R)-1-phenylethyl]azetidine-1-carboxamide	Investigative	482288	C20H20N2O3S	368.5	C[C@H](C1=CC=CC=C1)NC(=O)N2C(CC2=O)SCC(=O)C3=CC=CC=C3	IC50 ~ 75000 nM	Poor binder
T61484	Chymotrypsinogen B	B0FW9I	6-Iodomethylene-5-phenyl-tetrahydro-pyran-2-one	Investigative	13553454	C12H11IO2	314.12	C1CC(=O)O/C(=C/I)/C1C2=CC=CC=C2	Ki = 55000 nM	Poor binder
T61484	Chymotrypsin C	B0GZ1D	1-Naphthalenesulfonic acid, 3-hydroxy-4-[(1-hydroxy-2-naphthalenyl)azo]-	Investigative	19098	C20H14N2O5S	394.4	C1=CC=C2C(=C1)C=CC(=C2O)N=NC3=C(C=C(C4=CC=CC=C43)S(=O)(=O)O)O	IC50 = 90000 nM	Poor binder
T61484	Chymotrypsinogen B	B0Z8AI	N-((1S)-2-Hydroxy-1-phenylethyl)[2-oxo-4-(2-pyridylmethylthio)azetidinyl]carboxamide	Investigative	482292	C18H19N3O3S	357.4	C1C(N(C1=O)C(=O)N[C@H](CO)C2=CC=CC=C2)SCC3=CC=CC=N3	IC50 ~ 75000 nM	Poor binder
T61484	Chymotrypsin C	B13CZD	2H-Pyran-2-one, 5-phenyl-	Investigative	13615453	C11H8O2	172.18	C1=CC=C(C=C1)C2=COC(=O)C=C2	Ki = 75000 nM	Poor binder
T61484	Chymotrypsinogen B	B2C1NS	(3S)-N-[1-[[(2R)-Butan-2-yl]amino]-1,2-dioxohexan-3-yl]-2-[(2S)-2-[[(2S)-2-cyclohexyl-2-(pyrazine-2-carbonylamino)acetyl]amino]-3,3-dimethylbutanoyl]-3,3a,4,5,6,6a-hexahydro-1H-cyclopenta[c]pyrrole-3-carboxamide	Investigative	44394249	C37H57N7O6	695.9	CCCC(C(=O)C(=O)N[C@H](C)CC)NC(=O)[C@@H]1C2CCCC2CN1C(=O)[C@H](C(C)(C)C)NC(=O)[C@H](C3CCCCC3)NC(=O)C4=NC=CN=C4	Ki ~ 50000 nM	Poor binder
T61484	Chymotrypsin C	B2F5WP	[3,5-Dibutyl-2-oxo-6-(6-oxoundecan-5-yl)pyran-4-yl] acetate	Investigative	21603623	C26H42O5	434.6	CCCCCC(=O)C(CCCC)C1=C(C(=C(C(=O)O1)CCCC)OC(=O)C)CCCC	Ki = 190546.07 nM	Poor binder
T61484	Chymotrypsinogen B	B38EHD	4-[(1-Hydroxynaphthalen-2-yl)diazenyl]naphthalene-1-sulfonic acid	Investigative	136016313	C20H14N2O4S	378.4	C1=CC=C2C(=C1)C=CC(=C2O)N=NC3=CC=C(C4=CC=CC=C43)S(=O)(=O)O	IC50 = 90000 nM	Poor binder
T61484	Chymotrypsinogen B	B3P7QT	5-Chloro-2-[5-[(Z)-(3,8-dioxo-5,16-dithia-2,7-diazatetracyclo[7.7.0.02,6.010,15]hexadeca-1(9),6,10(15)-trien-4-ylidene)methyl]furan-2-yl]benzoic acid	Investigative	5876194	C24H15ClN2O5S2	511	C1CCC2=C(C1)C3=C(S2)N4C(=O)/C(=C/C5=CC=C(O5)C6=C(C=C(C=C6)Cl)C(=O)O)/SC4=NC3=O	IC50 = 72600 nM	Poor binder
T61484	Chymotrypsinogen B	B4M8LQ	4-{5-[(Z)-(5-Cyano-2-hydroxy-4-methyl-6-oxopyridin-3(6H)-ylidene)methyl]furan-2-yl}benzenesulfonamide	Investigative	2264784	C18H13N3O5S	383.4	CC\\1=C(C(=O)NC(=O)/C1=C\\C2=CC=C(O2)C3=CC=C(C=C3)S(=O)(=O)N)C#N	IC50 = 74100 nM	Poor binder
T61484	Chymotrypsinogen B	B5BL3Q	(1E,6E)-4-(1,3-Dithian-2-ylidene)-1,7-bis(furan-2-yl)hepta-1,6-diene-3,5-dione	Investigative	1269450	C19H16O4S2	372.5	C1CSC(=C(C(=O)/C=C/C2=CC=CO2)C(=O)/C=C/C3=CC=CO3)SC1	IC50 = 90300 nM	Poor binder
T61484	Chymotrypsin C	B5FHE8	2-Naphthalen-2-yl-6-p-tolyl-isonicotinic acid	Investigative	20443937	C23H17NO2	339.4	CC1=CC=C(C=C1)C2=NC(=CC(=C2)C(=O)O)C3=CC4=CC=CC=C4C=C3	IC50 = 50000 nM	Poor binder
T61484	Chymotrypsinogen B	B5G0QS	Chembl365415	Investigative	15955412	C34H51N7O6	653.8	CCC[C@@H](C(=O)C(=O)NC1CC1)NC(=O)[C@@H]2C3CCCC3CN2C(=O)[C@H](C(C)(C)C)NC(=O)[C@H](C(C)(C)C)NC(=O)C4=NC=CN=C4	Ki ~ 50000 nM	Poor binder
T61484	Chymotrypsinogen B	B5J9FW	2-(2-{2-Cyclohexyl-2-[(pyrazine-2-carbonyl)-amino]-acetylamino}-3,3-dimethyl-butyryl)-octahydro-cyclopenta[c]pyrrole-1-carboxylic acid (1-cyclopropylaminooxalyl-3,3-difluoro-propyl)-amide	Investigative	3011892	C35H49F2N7O6	701.8	CC(C)(C)[C@@H](C(=O)N1CC2CCCC2[C@H]1C(=O)NC(CC(F)F)C(=O)C(=O)NC3CC3)NC(=O)[C@H](C4CCCCC4)NC(=O)C5=NC=CN=C5	Ki ~ 50000 nM	Poor binder
T61484	Chymotrypsin C	B6CMA3	2-Chloro-benzenesulfonic acid 3-(1-carbamimidoyl-piperidin-3-ylmethoxy)-5-methyl-phenyl ester	Investigative	44287798	C20H24ClN3O4S	437.9	CC1=CC(=CC(=C1)OS(=O)(=O)C2=CC=CC=C2Cl)OCC3CCCN(C3)C(=N)N	Ki = 72000 nM	Poor binder
T61484	Chymotrypsinogen B	B6JPV8	N-((1R)-1-Phenylethyl)[2-oxo-4-(2-pyridylmethylthio)azetidinyl]carboxamide	Investigative	482287	C18H19N3O2S	341.4	C[C@H](C1=CC=CC=C1)NC(=O)N2C(CC2=O)SCC3=CC=CC=N3	IC50 ~ 75000 nM	Poor binder
T61484	Chymotrypsin C	B6RJN1	3-(4-{[(S)-1-(2-Tert-Butoxycarbonylamino-4-carboxy-butyryl)-pyrrolidine-2-carbonyl]-amino}-2,2-difluoro-3-oxo-5-phenyl-pentanoylamino)-naphthalene-1-carboxylic acid	Investigative	44382957	C37H40F2N4O10	738.7	CC(C)(C)OC(=O)NC(CCC(=O)O)C(=O)N1CCC[C@H]1C(=O)NC(CC2=CC=CC=C2)C(=O)C(C(=O)NC3=CC4=CC=CC=C4C(=C3)C(=O)O)(F)F	Ki = 92900 nM	Poor binder
T61484	Chymotrypsin C	B7NTI8	4-[2-(2,4-Difluoroanilino)-4-thiazolyl]pyrocatechol	Investigative	5190983	C15H10F2N2O2S	320.3	C1=CC(=C(C=C1C2=CSC(=N2)NC3=C(C=C(C=C3)F)F)O)O	IC50 = 100000 nM	Poor binder
T61484	Chymotrypsinogen B	B7NTI8	4-[2-(2,4-Difluoroanilino)-4-thiazolyl]pyrocatechol	Investigative	5190983	C15H10F2N2O2S	320.3	C1=CC(=C(C=C1C2=CSC(=N2)NC3=C(C=C(C=C3)F)F)O)O	IC50 = 100000 nM	Poor binder
T61484	Chymotrypsinogen B	B7WK2D	N-((1R)-1-Phenylpropyl)[2-oxo-4-(2-pyridylmethylthio)azetidinyl]carboxamide	Investigative	482290	C19H21N3O2S	355.5	CC[C@H](C1=CC=CC=C1)NC(=O)N2C(CC2=O)SCC3=CC=CC=N3	IC50 ~ 75000 nM	Poor binder
T61484	Chymotrypsinogen B	B8PY5V	(5Z)-5-[(2,4-Dihydroxyphenyl)methylidene]-2-sulfanylideneimidazolidin-4-one	Investigative	7028541	C10H8N2O3S	236.25	C1=CC(=C(C=C1O)O)/C=C\\2/C(=O)NC(=S)N2	IC50 = 143600 nM	Poor binder
T61484	Chymotrypsin C	B98TPM	2H-Pyran-2-one, 6-chloro-5-(phenylmethyl)-	Investigative	44270803	C12H9ClO2	220.65	C1=CC=C(C=C1)CC2=C(OC(=O)C=C2)Cl	Ki = 50000 nM	Poor binder
T61484	Chymotrypsin C	B9OXD2	6-Chloro-5-naphthalen-2-ylmethyl-pyran-2-one	Investigative	13615447	C16H11ClO2	270.71	C1=CC=C2C=C(C=CC2=C1)CC3=C(OC(=O)C=C3)Cl	Ki = 63000 nM	Poor binder
T61484	Chymotrypsin C	BA23PG	2-(4-(6-Bromo-1-hydroxy-2-naphthylazo)phenoxy)acetic acid	Investigative	4422179	C18H13BrN2O4	401.2	C1=CC(=CC=C1N=NC2=C(C3=C(C=C2)C=C(C=C3)Br)O)OCC(=O)O	IC50 = 80000 nM	Poor binder
T61484	Chymotrypsinogen B	BAUK64	(S)-Ethyl 1-(5-(4-phenethoxybenzyl)-1,2,4-oxadiazol-3-yl)-6-amino-1-oxohexan-2-ylcarbamate	Investigative	15984063	C26H32N4O5	480.6	CCOC(=O)N[C@@H](CCCCN)C(=O)C1=NOC(=N1)CC2=CC=C(C=C2)OCCC3=CC=CC=C3	Ki ~ 150000 nM	Poor binder
T61484	Chymotrypsin C	BB4EU2	3-[[(3R,3Ar,6aS)-2-oxo-3,3a,4,5,6,6a-hexahydrocyclopenta[b]furan-3-yl]methyl]benzenecarboximidamide;acetic acid	Investigative	44331422	C17H22N2O4	318.4	CC(=O)O.C1C[C@H]2[C@H](C1)OC(=O)[C@@H]2CC3=CC(=CC=C3)C(=N)N	IC50 ~ 100000 nM	Poor binder
T61484	Chymotrypsin C	BB67TI	(4S)-4-[[(2S)-2-Amino-3-carboxypropanoyl]amino]-5-[[(2S)-3-methyl-1-[[(2S)-3-methyl-1-oxo-1-[(2R)-2-[[(1R)-3-(4-phenoxyphenyl)-1-[(1S,2S,6R,8S)-2,9,9-trimethyl-3,5-dioxa-4-boratricyclo[6.1.1.02,6]decan-4-yl]propyl]carbamoyl]pyrrolidin-1-yl]butan-2-yl]amino]-1-oxobutan-2-yl]amino]-5-oxopentanoic acid	Investigative	44338659	C49H69BN6O12	944.9	B1(O[C@@H]2C[C@@H]3C[C@H]([C@@]2(O1)C)C3(C)C)[C@H](CCC4=CC=C(C=C4)OC5=CC=CC=C5)NC(=O)[C@H]6CCCN6C(=O)[C@H](C(C)C)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(=O)O)N	IC50 ~ 60000 nM	Poor binder
T61484	Chymotrypsinogen B	BB7OU5	N-((1R)-1-Phenylethyl)(2-oxo-4-phenylthioazetidinyl)carboxamide	Investigative	482282	C18H18N2O2S	326.4	C[C@H](C1=CC=CC=C1)NC(=O)N2C(CC2=O)SC3=CC=CC=C3	IC50 ~ 75000 nM	Poor binder
T61484	Chymotrypsin C	BB9RO4	Rose Bengal lactone	Investigative	69439	C20H4Cl4I4O5	973.7	C1=C2C(=C(C(=C1I)O)I)OC3=C(C(=C(C=C3C24C5=C(C(=C(C(=C5Cl)Cl)Cl)Cl)C(=O)O4)I)O)I	IC50 = 50000 nM	Poor binder
T61484	Chymotrypsin C	BBN1E5	3-Benzyl-6-chloro-2-pyrone	Investigative	135053	C12H9ClO2	220.65	C1=CC=C(C=C1)CC2=CC=C(OC2=O)Cl	Ki = 76000 nM	Poor binder
T61484	Chymotrypsinogen B	BC2W1E	Indirubin	Investigative	10177	C16H10N2O2	262.26	C1=CC=C2C(=C1)C(=C(N2)O)C3=NC4=CC=CC=C4C3=O	IC50 = 100000 nM	Poor binder
T61484	Chymotrypsin C	BC3TB2	2H-Pyran-2-one, 6-bromo-3-(phenylmethyl)-	Investigative	13615438	C12H9BrO2	265.1	C1=CC=C(C=C1)CC2=CC=C(OC2=O)Br	Ki = 112000 nM	Poor binder
T61484	Chymotrypsinogen B	BC9M0N	N-((1R)-1-Phenylethyl)[2-oxo-4-(3-pyridylmethylthio)azetidinyl]carboxamide	Investigative	482286	C18H19N3O2S	341.4	C[C@H](C1=CC=CC=C1)NC(=O)N2C(CC2=O)SCC3=CN=CC=C3	IC50 ~ 75000 nM	Poor binder
T61484	Chymotrypsin C	BCG56V	[Tris-(2,2-dicarboxycyclopropyl)]-Buckmins model	Investigative	44293166	C69H6O12	1026.8	C12=C3C4=C5C6=C1C7=C8C6=C9C1=C6C%10=C%11C%12=C%13C(=C9%10)C8=C8C%139C%10(C9(C(=O)O)C(=O)O)C9=C%13C8=C7C7=C2C2=C3C3=C8C%14=C%15C%16=C%17C%18=C%14C3=C4C(=C51)C%18=C6C%171C%11(C1(C(=O)O)C(=O)O)C1=C%16C3=C(C9=C4C(=C7%13)C2=C8C42C%153C2(C(=O)O)C(=O)O)C%10=C%121	IC50 = 60000 nM	Poor binder
T61484	Chymotrypsin C	BCP3L8	3-[((3E)-3-{[(E)-Amino(imino)methyl]hydrazono}propyl)oxy]-5-methylphenyl 2-(trifluoromethoxy)benzenesulfonate	Investigative	44352031	C18H19F3N4O5S	460.4	CC1=CC(=CC(=C1)OS(=O)(=O)C2=CC=CC=C2OC(F)(F)F)OCC/C=N/N=C(N)N	Ki = 88000 nM	Poor binder
T61484	Chymotrypsin C	BD3U9F	2H-Pyran-2-one, 3-(phenylmethyl)-	Investigative	13660351	C12H10O2	186.21	C1=CC=C(C=C1)CC2=CC=COC2=O	Ki = 160000 nM	Poor binder
T61484	Chymotrypsinogen B	BE6S4C	Tert-butyl 2-[4-[[4-oxo-1-[[(1R)-1-phenylethyl]carbamoyl]azetidin-2-yl]sulfanylmethyl]phenyl]acetate	Investigative	482289	C25H30N2O4S	454.6	C[C@H](C1=CC=CC=C1)NC(=O)N2C(CC2=O)SCC3=CC=C(C=C3)CC(=O)OC(C)(C)C	IC50 ~ 75000 nM	Poor binder
T61484	Chymotrypsin C	BER68J	6-Chloro-3-naphthalen-1-ylmethyl-pyran-2-one	Investigative	13615437	C16H11ClO2	270.71	C1=CC=C2C(=C1)C=CC=C2CC3=CC=C(OC3=O)Cl	Ki = 93000 nM	Poor binder
T61484	Chymotrypsin C	BEW06C	(4S)-4-[[(2S)-2-Amino-3-carboxypropanoyl]amino]-5-[[(2S)-3-methyl-1-[[(2S)-3-methyl-1-oxo-1-[(2R)-2-[[(1R)-1-[(1S,2S,6R,8S)-2,9,9-trimethyl-3,5-dioxa-4-boratricyclo[6.1.1.02,6]decan-4-yl]propyl]carbamoyl]pyrrolidin-1-yl]butan-2-yl]amino]-1-oxobutan-2-yl]amino]-5-oxopentanoic acid	Investigative	44338821	C37H61BN6O11	776.7	B1(O[C@@H]2C[C@@H]3C[C@H]([C@@]2(O1)C)C3(C)C)[C@H](CC)NC(=O)[C@H]4CCCN4C(=O)[C@H](C(C)C)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(=O)O)N	IC50 ~ 60000 nM	Poor binder
T61484	Chymotrypsin C	BF31GU	5-(4-{[(S)-1-(2-Tert-Butoxycarbonylamino-4-carboxy-butyryl)-pyrrolidine-2-carbonyl]-amino}-2,2-difluoro-3-oxo-5-phenyl-pentanoylamino)-thiophene-3-carboxylic acid	Investigative	44383483	C31H36F2N4O10S	694.7	CC(C)(C)OC(=O)NC(CCC(=O)O)C(=O)N1CCC[C@H]1C(=O)NC(CC2=CC=CC=C2)C(=O)C(C(=O)NC3=CC(=CS3)C(=O)O)(F)F	Ki ~ 100000 nM	Poor binder
T61484	Chymotrypsinogen B	BH5SG9	[2-Oxo-4-(2-pyridylmethylthio)azetidinyl]-N-[2-(phenylmethoxy)ethyl]carboxamide	Investigative	482291	C19H21N3O3S	371.5	C1C(N(C1=O)C(=O)NCCOCC2=CC=CC=C2)SCC3=CC=CC=N3	IC50 ~ 75000 nM	Poor binder
T61484	Chymotrypsin C	BI4K5L	4-[[(3R,3Ar,6aS)-2-oxo-3,3a,4,5,6,6a-hexahydrocyclopenta[b]furan-3-yl]methyl]benzenecarboximidamide;acetic acid	Investigative	44331418	C17H22N2O4	318.4	CC(=O)O.C1C[C@H]2[C@H](C1)OC(=O)[C@@H]2CC3=CC=C(C=C3)C(=N)N	IC50 = 70300 nM	Poor binder
T61484	Chymotrypsinogen B	BJ98LI	N-[(2S)-6-Amino-1-[5-[[4-[2-(3,4-dichlorophenyl)ethoxy]phenyl]methyl]-1,2,4-oxadiazol-3-yl]-1-oxohexan-2-yl]-3,4-difluorobenzamide;hydrochloride	Investigative	45263389	C30H29Cl3F2N4O4	653.9	C1=CC(=CC=C1CC2=NC(=NO2)C(=O)[C@H](CCCCN)NC(=O)C3=CC(=C(C=C3)F)F)OCCC4=CC(=C(C=C4)Cl)Cl.Cl	Ki ~ 150000 nM	Poor binder
T61484	Chymotrypsin C	BJNW78	(4S)-4-[[(2S)-2-Amino-3-carboxypropanoyl]amino]-5-[[(2S)-3-methyl-1-[[(2S)-3-methyl-1-oxo-1-[(2R)-2-[[(1R)-3-(4-propan-2-ylphenyl)-1-[(1S,2S,6R,8S)-2,9,9-trimethyl-3,5-dioxa-4-boratricyclo[6.1.1.02,6]decan-4-yl]propyl]carbamoyl]pyrrolidin-1-yl]butan-2-yl]amino]-1-oxobutan-2-yl]amino]-5-oxopentanoic acid	Investigative	44338660	C46H71BN6O11	894.9	B1(O[C@@H]2C[C@@H]3C[C@H]([C@@]2(O1)C)C3(C)C)[C@H](CCC4=CC=C(C=C4)C(C)C)NC(=O)[C@H]5CCCN5C(=O)[C@H](C(C)C)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(=O)O)N	IC50 ~ 60000 nM	Poor binder
T61484	Chymotrypsin C	BJV9D5	(4S)-4-[[(2S)-2-Amino-3-carboxypropanoyl]amino]-5-[[(2S)-1-[[(2S)-1-[(2R)-2-[[(1R)-3-(4-cyclohexylphenyl)-1-[(1S,2S,6R,8S)-2,9,9-trimethyl-3,5-dioxa-4-boratricyclo[6.1.1.02,6]decan-4-yl]propyl]carbamoyl]pyrrolidin-1-yl]-3-methyl-1-oxobutan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-5-oxopentanoic acid	Investigative	44338820	C49H75BN6O11	935	B1(O[C@@H]2C[C@@H]3C[C@H]([C@@]2(O1)C)C3(C)C)[C@H](CCC4=CC=C(C=C4)C5CCCCC5)NC(=O)[C@H]6CCCN6C(=O)[C@H](C(C)C)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(=O)O)N	IC50 ~ 60000 nM	Poor binder
T61484	Chymotrypsin C	BKAJ58	3,6-Bis((4-bromo-2-sulphophenyl)azo)-4,5-dihydroxynaphthalene-2,7-disulphonic acid	Investigative	135445689	C22H14Br2N4O14S4	846.4	C1=CC(=C(C=C1Br)S(=O)(=O)O)N=NC2=C(C3=C(C(=C(C=C3C=C2S(=O)(=O)O)S(=O)(=O)O)N=NC4=C(C=C(C=C4)Br)S(=O)(=O)O)O)O	IC50 = 110000 nM	Poor binder
T61484	Chymotrypsinogen B	BKDI19	Chembl364471	Investigative	73347119	C34H51N7O6	653.8	CCC[C@@H](C(=O)C(=O)NC1CC1)NC(=O)[C@@H]2C3CCCC3CN2C(=O)[C@H](C(C)(C)C)NC(=O)[C@H]([C@@H](C)CC)NC(=O)C4=NC=CN=C4	Ki ~ 50000 nM	Poor binder
T61484	Chymotrypsinogen B	BLI34B	2-[(2S)-2-[[(2S)-2-(3,3-Dimethylbutanoylamino)-3,3-dimethylbutanoyl]amino]-4-methylpentyl]sulfanyl-4-oxo-N-[(1S)-1-phenylpropyl]azetidine-1-carboxamide	Investigative	44282051	C31H50N4O4S	574.8	CC[C@@H](C1=CC=CC=C1)NC(=O)N2C(CC2=O)SC[C@H](CC(C)C)NC(=O)[C@H](C(C)(C)C)NC(=O)CC(C)(C)C	IC50 ~ 75000 nM	Poor binder
T61484	Chymotrypsinogen B	BO3HD9	(3S)-2-[(2S)-2-[[(2S)-2-Cyclohexyl-2-(pyrazine-2-carbonylamino)acetyl]amino]-3,3-dimethylbutanoyl]-N-[1,2-dioxo-1-[[(1R)-1-phenylethyl]amino]hexan-3-yl]-3,3a,4,5,6,6a-hexahydro-1H-cyclopenta[c]pyrrole-3-carboxamide	Investigative	44394250	C41H57N7O6	743.9	CCCC(C(=O)C(=O)N[C@H](C)C1=CC=CC=C1)NC(=O)[C@@H]2C3CCCC3CN2C(=O)[C@H](C(C)(C)C)NC(=O)[C@H](C4CCCCC4)NC(=O)C5=NC=CN=C5	Ki ~ 50000 nM	Poor binder
T61484	Chymotrypsin C	BOQ10E	3-(4-{[(S)-1-(2-Tert-Butoxycarbonylamino-3-carboxy-propionyl)-pyrrolidine-2-carbonyl]-amino}-2,2-difluoro-3-oxo-5-phenyl-pentanoylamino)-benzoic acid	Investigative	44384376	C32H36F2N4O10	674.6	CC(C)(C)OC(=O)NC(CC(=O)O)C(=O)N1CCC[C@H]1C(=O)NC(CC2=CC=CC=C2)C(=O)C(C(=O)NC3=CC=CC(=C3)C(=O)O)(F)F	Ki ~ 100000 nM	Poor binder
T61484	Chymotrypsinogen B	BOT71R	N-[(S)-alpha-[4-(2-Fluoroethyl)piperidinocarbonyl]-4-aminobenzyl]-4-[[(S)-alpha-(hydroxymethyl)phenethyl]amino]pyridine-3-sulfonamide	Investigative	10483116	C29H36FN5O4S	569.7	C1CN(CCC1CCF)C(=O)[C@H](C2=CC=C(C=C2)N)NS(=O)(=O)C3=C(C=CN=C3)N[C@@H](CC4=CC=CC=C4)CO	Ki = 115250 nM	Poor binder
T61484	Chymotrypsinogen B	BOV2E3	((S)-2,2-Dimethyl-1-{(S)-3-methyl-1-[4-oxo-1-((R)-1-phenyl-ethylcarbamoyl)-azetidin-2-yloxymethyl]-butylcarbamoyl}-propyl)-carbamic acid tert-butyl ester	Investigative	482278	C29H46N4O6	546.7	C[C@H](C1=CC=CC=C1)NC(=O)N2C(CC2=O)OC[C@H](CC(C)C)NC(=O)[C@H](C(C)(C)C)NC(=O)OC(C)(C)C	IC50 ~ 75000 nM	Poor binder
T61484	Chymotrypsinogen B	BQB9A5	2-Oxo-4-phenethylsulfanyl-N-[(1R)-1-phenylethyl]azetidine-1-carboxamide	Investigative	482284	C20H22N2O2S	354.5	C[C@H](C1=CC=CC=C1)NC(=O)N2C(CC2=O)SCCC3=CC=CC=C3	IC50 ~ 75000 nM	Poor binder
T61484	Chymotrypsin C	BQFI94	CID 14799980	Investigative	14799980	C28H37NO	403.6	C[C@]12CC[C@H]3[C@H]([C@@H]1CC[C@@H]2NCCCC4=CC=CC=C4)CCC5=C3C=CC(=C5)OC	IC50 = 200000 nM	Poor binder
T61484	Chymotrypsin C	BQY91R	2-Butyl-2-(3,5-dibutyl-4-hydroxy-6-oxopyran-2-yl)octanal	Investigative	54732424	C25H42O4	406.6	CCCCCCC(CCCC)(C=O)C1=C(C(=C(C(=O)O1)CCCC)O)CCCC	Ki = 134896.29 nM	Poor binder
T61484	Chymotrypsinogen B	BR2JP5	(3S,3As,6aR)-2-[(2S)-2-[[(2S)-2-cyclohexyl-2-(pyrazine-2-carbonylamino)acetyl]amino]-3,3-dimethylbutanoyl]-N-[1-(cyclopropylamino)-1,2-dioxohexan-3-yl]-3,3a,4,5,6,6a-hexahydro-1H-cyclopenta[c]pyrrole-3-carboxamide	Investigative	3088969	C36H53N7O6	679.8	CCCC(C(=O)C(=O)NC1CC1)NC(=O)[C@@H]2[C@H]3CCC[C@H]3CN2C(=O)[C@H](C(C)(C)C)NC(=O)[C@H](C4CCCCC4)NC(=O)C5=NC=CN=C5	Ki ~ 50000 nM	Poor binder
T61484	Chymotrypsinogen B	BR7N9G	Chembl184525	Investigative	73350210	C33H49N7O7	655.8	CCC[C@@H](C(=O)C(=O)NC1CC1)NC(=O)[C@@H]2C3CCCC3CN2C(=O)[C@H](C(C)(C)C)NC(=O)[C@H]([C@@H](C)OC)NC(=O)C4=NC=CN=C4	Ki ~ 50000 nM	Poor binder
T61484	Chymotrypsinogen B	BRT8S9	((S)-2,2-Dimethyl-1-{(S)-3-methyl-1-[4-oxo-1-((S)-1-phenyl-ethylcarbamoyl)-azetidin-2-yloxymethyl]-butylcarbamoyl}-propyl)-carbamic acid tert-butyl ester	Investigative	482279	C29H46N4O6	546.7	C[C@@H](C1=CC=CC=C1)NC(=O)N2C(CC2=O)OC[C@H](CC(C)C)NC(=O)[C@H](C(C)(C)C)NC(=O)OC(C)(C)C	IC50 ~ 75000 nM	Poor binder
T61484	Chymotrypsinogen B	BRXD64	Indigo	Investigative	10215	C16H10N2O2	262.26	C1=CC=C2C(=C1)C(=C(N2)C3=NC4=CC=CC=C4C3=O)O	IC50 = 90000 nM	Poor binder
T61484	Chymotrypsin C	BU2T4G	2-Chloro-benzenesulfonic acid 3-(5-guanidino-pentyloxy)-5-methyl-phenyl ester	Investigative	44287797	C19H24ClN3O4S	425.9	CC1=CC(=CC(=C1)OS(=O)(=O)C2=CC=CC=C2Cl)OCCCCCN=C(N)N	Ki = 80000 nM	Poor binder
T61484	Chymotrypsin C	BU9O7D	5-[(3R,3Ar,6aS)-2-oxo-3,3a,4,5,6,6a-hexahydrocyclopenta[b]furan-3-yl]pentanimidamide;acetic acid	Investigative	44331420	C14H24N2O4	284.35	CC(=O)O.C1C[C@H]2[C@H](C1)OC(=O)[C@@H]2CCCCC(=N)N	IC50 ~ 100000 nM	Poor binder
T61484	Chymotrypsinogen B	BV2GX4	(3S,3As,6aR)-N-[1-(cyclopropylamino)-1,2-dioxohexan-3-yl]-2-[(2S)-3,3-dimethyl-2-[[(2S)-3-methyl-2-(pyrazine-2-carbonylamino)butanoyl]amino]butanoyl]-3,3a,4,5,6,6a-hexahydro-1H-cyclopenta[c]pyrrole-3-carboxamide	Investigative	10461790	C33H49N7O6	639.8	CCCC(C(=O)C(=O)NC1CC1)NC(=O)[C@@H]2[C@H]3CCC[C@H]3CN2C(=O)[C@H](C(C)(C)C)NC(=O)[C@H](C(C)C)NC(=O)C4=NC=CN=C4	Ki ~ 50000 nM	Poor binder
T61484	Chymotrypsin C	BV6BW9	N'1,N'2-Bis(2-Hydroxybenzylidene)Oxalohydrazide	Investigative	135576411	C16H14N4O4	326.31	C1=CC=C(C(=C1)/C=N/NC(=O)C(=O)N/N=C/C2=CC=CC=C2O)O	IC50 = 55000 nM	Poor binder
T61484	Chymotrypsinogen B	BXE52A	2-Benzylsulfanyl-4-oxo-N-[(1R)-1-phenylethyl]azetidine-1-carboxamide	Investigative	482283	C19H20N2O2S	340.4	C[C@H](C1=CC=CC=C1)NC(=O)N2C(CC2=O)SCC3=CC=CC=C3	IC50 ~ 75000 nM	Poor binder
T61484	Chymotrypsinogen B	BY8K2X	2-[1-(3-Dimethylaminopropyl)-1H-indol-3-yl]-3-(1H-indol-3-yl)-maleimide	Investigative	5327726	C26H26N4O2	426.5	CN1C=C(C2=CC=CC=C21)C3=C(C(=O)NC3=O)C4=CN(C5=CC=CC=C54)CCCN(C)C	IC50 = 200000 nM	Poor binder
T61484	Chymotrypsinogen B	BZ20PF	N-((1R)-1-Phenylethyl)[2-oxo-4-(4-pyridylmethylthio)azetidinyl]carboxamide	Investigative	482285	C18H19N3O2S	341.4	C[C@H](C1=CC=CC=C1)NC(=O)N2C(CC2=O)SCC3=CC=NC=C3	IC50 ~ 75000 nM	Poor binder
T61484	Chymotrypsin C	BZI1U2	3,5-Dibutyl-4-hydroxy-6-(1-oxo-1-phenylhexan-2-yl)pyran-2-one	Investigative	54707146	C25H34O4	398.5	CCCCC1=C(C(=C(OC1=O)C(CCCC)C(=O)C2=CC=CC=C2)CCCC)O	Ki = 79432.82 nM	Poor binder
T61484	Chymotrypsinogen B	D0GD8Y	U0126	Investigative	3006531	C18H16N6S2	380.5	C1=CC=C(C(=C1)N)S/C(=C(/C(=C(/SC2=CC=CC=C2N)\\N)/C#N)\\C#N)/N	IC50 = 120000 nM	Poor binder