TTD_Target_ID	Target_Name	TTD_Drug_ID	Drug_Name	Drug_Highest_Status	Drug_PubchemID	Molecular_Formula	Molecular_Weight	Canonical_SMILES	Activity	Binder_Type
T62184	GABA transporter GAT-1	B0ID7G	1-{2-[Tris-(4-fluoro-phenyl)-methoxy]-ethyl}-piperidine-3-carboxylic acid	Investigative	10050339	C27H26F3NO3	469.5	C1CC(CN(C1)CCOC(C2=CC=C(C=C2)F)(C3=CC=C(C=C3)F)C4=CC=C(C=C4)F)C(=O)O	IC50 = 58000 nM	Poor binder
T62184	GABA transporter GAT-1	B1GDX4	2,4-Dichloro-N-[1-[(4-iodophenyl)methyl]piperidin-4-yl]benzamide	Investigative	137639241	C19H19Cl2IN2O	489.2	C1CN(CCC1NC(=O)C2=C(C=C(C=C2)Cl)Cl)CC3=CC=C(C=C3)I	IC50 ~ 100000 nM	Poor binder
T62184	GABA transporter GAT-1	B2OQ0Z	2,4-Dichloro-N-[1-[(2-nitrophenyl)methyl]piperidin-4-yl]benzamide	Investigative	137657292	C19H19Cl2N3O3	408.3	C1CN(CCC1NC(=O)C2=C(C=C(C=C2)Cl)Cl)CC3=CC=CC=C3[N+](=O)[O-]	IC50 ~ 100000 nM	Poor binder
T62184	GABA transporter GAT-1	B36YMB	1-{2-[Bis-(4-chloro-phenyl)-(4-methoxy-phenyl)-methoxy]-ethyl}-piperidine-3-carboxylic acid	Investigative	10481573	C28H29Cl2NO4	514.4	COC1=CC=C(C=C1)C(C2=CC=C(C=C2)Cl)(C3=CC=C(C=C3)Cl)OCCN4CCCC(C4)C(=O)O	IC50 = 122000 nM	Poor binder
T62184	GABA transporter GAT-1	B3T7ZJ	1-{2-[(4-Methoxy-phenyl)-di-p-tolyl-methoxy]-ethyl}-piperidine-3-carboxylic acid	Investigative	10412575	C30H35NO4	473.6	CC1=CC=C(C=C1)C(C2=CC=C(C=C2)C)(C3=CC=C(C=C3)OC)OCCN4CCCC(C4)C(=O)O	IC50 = 142000 nM	Poor binder
T62184	GABA transporter GAT-1	B4E2FN	1-{2-[(4-Methoxy-3-trifluoromethyl-phenyl)-phenyl-(3-trifluoromethyl-phenyl)-methoxy]-ethyl}-piperidine-3-carboxylic acid	Investigative	10031163	C30H29F6NO4	581.5	COC1=C(C=C(C=C1)C(C2=CC=CC=C2)(C3=CC(=CC=C3)C(F)(F)F)OCCN4CCCC(C4)C(=O)O)C(F)(F)F	IC50 = 73000 nM	Poor binder
T62184	GABA transporter GAT-1	B5JF9L	(1s,2s,5r)-5-Aminobicyclo[3.1.0]hexane-2-carboxylic acid	Investigative	118711599	C7H11NO2	141.17	C1C[C@]2(C[C@H]2[C@H]1C(=O)O)N	IC50 ~ 100000 nM	Poor binder
T62184	GABA transporter GAT-1	B5JUH7	2,4-Dichloro-N-[1-(naphthalen-2-ylmethyl)piperidin-4-yl]benzamide	Investigative	137638838	C23H22Cl2N2O	413.3	C1CN(CCC1NC(=O)C2=C(C=C(C=C2)Cl)Cl)CC3=CC4=CC=CC=C4C=C3	IC50 ~ 50000 nM	Poor binder
T62184	GABA transporter GAT-1	B5VY1Q	2,4-Dichloro-N-[1-[(2-cyanophenyl)methyl]piperidin-4-yl]benzamide	Investigative	137654858	C20H19Cl2N3O	388.3	C1CN(CCC1NC(=O)C2=C(C=C(C=C2)Cl)Cl)CC3=CC=CC=C3C#N	IC50 ~ 50000 nM	Poor binder
T62184	GABA transporter GAT-1	B67NTR	N-(1-Benzyl-4-piperidinyl)-1,3-benzodioxole-5-carboxamide	Investigative	9884272	C20H22N2O3	338.4	C1CN(CCC1NC(=O)C2=CC3=C(C=C2)OCO3)CC4=CC=CC=C4	Ki ~ 100000 nM	Poor binder
T62184	GABA transporter GAT-1	B6OT7V	1-[4,4-Bis(3-methylthiophen-2-yl)but-3-enyl]piperidine-4-carboxylic acid;hydrochloride	Investigative	45263296	C20H26ClNO2S2	412	CC1=C(SC=C1)C(=CCCN2CCC(CC2)C(=O)O)C3=C(C=CS3)C.Cl	IC50 ~ 100000 nM	Poor binder
T62184	GABA transporter GAT-1	B6XF0Q	2,4-Dichloro-N-[1-[(E)-3-phenylprop-2-enyl]piperidin-4-yl]benzamide	Investigative	137638836	C21H22Cl2N2O	389.3	C1CN(CCC1NC(=O)C2=C(C=C(C=C2)Cl)Cl)C/C=C/C3=CC=CC=C3	IC50 ~ 100000 nM	Poor binder
T62184	GABA transporter GAT-1	B89XQC	Methyl 4-[[4-[(2,4-dichlorobenzoyl)amino]piperidin-1-yl]methyl]benzoate	Investigative	137642163	C21H22Cl2N2O3	421.3	COC(=O)C1=CC=C(C=C1)CN2CCC(CC2)NC(=O)C3=C(C=C(C=C3)Cl)Cl	IC50 ~ 100000 nM	Poor binder
T62184	GABA transporter GAT-1	BA3GC5	(3R)-1-[4,4-Bis[3-(naphthalen-1-yloxymethyl)thiophen-2-yl]but-3-enyl]piperidine-3-carboxylic acid;hydrochloride	Investigative	45265752	C40H38ClNO4S2	696.3	C1C[C@H](CN(C1)CCC=C(C2=C(C=CS2)COC3=CC=CC4=CC=CC=C43)C5=C(C=CS5)COC6=CC=CC7=CC=CC=C76)C(=O)O.Cl	IC50 = 66300 nM	Poor binder
T62184	GABA transporter GAT-1	BBFR86	1-{2-[Tris-(4-methoxy-phenyl)-methylsulfanyl]-ethyl}-piperidine-3-carboxylic acid	Investigative	10075407	C30H35NO5S	521.7	COC1=CC=C(C=C1)C(C2=CC=C(C=C2)OC)(C3=CC=C(C=C3)OC)SCCN4CCCC(C4)C(=O)O	IC50 = 78000 nM	Poor binder
T62184	GABA transporter GAT-1	BBML08	1-[4,4-Bis[3-(naphthalen-1-yloxymethyl)thiophen-2-yl]but-3-enyl]piperidine-4-carboxylic acid;hydrochloride	Investigative	45263313	C40H38ClNO4S2	696.3	C1CN(CCC1C(=O)O)CCC=C(C2=C(C=CS2)COC3=CC=CC4=CC=CC=C43)C5=C(C=CS5)COC6=CC=CC7=CC=CC=C76.Cl	IC50 ~ 100000 nM	Poor binder
T62184	GABA transporter GAT-1	BGL58X	2,4-Dichloro-N-[1-[(4-cyanophenyl)methyl]piperidin-4-yl]benzamide	Investigative	137658990	C20H19Cl2N3O	388.3	C1CN(CCC1NC(=O)C2=C(C=C(C=C2)Cl)Cl)CC3=CC=C(C=C3)C#N	IC50 ~ 50000 nM	Poor binder
T62184	GABA transporter GAT-1	BI4YL8	N-(1-Benzylpiperidin-4-yl)-2,4-dichlorobenzamide	Investigative	1069892	C19H20Cl2N2O	363.3	C1CN(CCC1NC(=O)C2=C(C=C(C=C2)Cl)Cl)CC3=CC=CC=C3	Ki ~ 100000 nM	Poor binder
T62184	GABA transporter GAT-1	BJ9W7E	1-{3-[Tris-(4-methoxy-phenyl)-methoxy]-propyl}-piperidine-3-carboxylic acid	Investigative	10052359	C31H37NO6	519.6	COC1=CC=C(C=C1)C(C2=CC=C(C=C2)OC)(C3=CC=C(C=C3)OC)OCCCN4CCCC(C4)C(=O)O	IC50 = 121000 nM	Poor binder
T62184	GABA transporter GAT-1	BJHW74	2,4-Dichloro-N-(1-phenacylpiperidin-4-yl)benzamide	Investigative	137638617	C20H20Cl2N2O2	391.3	C1CN(CCC1NC(=O)C2=C(C=C(C=C2)Cl)Cl)CC(=O)C3=CC=CC=C3	IC50 ~ 100000 nM	Poor binder
T62184	GABA transporter GAT-1	BKN67T	1-[4,4-Bis[3-(naphthalen-1-yloxymethyl)thiophen-2-yl]but-3-enyl]piperidine-2-carboxylic acid;hydrochloride	Investigative	45263315	C40H38ClNO4S2	696.3	C1CCN(C(C1)C(=O)O)CCC=C(C2=C(C=CS2)COC3=CC=CC4=CC=CC=C43)C5=C(C=CS5)COC6=CC=CC7=CC=CC=C76.Cl	IC50 ~ 100000 nM	Poor binder
T62184	GABA transporter GAT-1	BM4K7U	2-[(1S,2R)-2-Aminocyclopropyl]acetic acid;hydrochloride	Investigative	71769499	C5H10ClNO2	151.59	C1[C@H]([C@@H]1N)CC(=O)O.Cl	IC50 ~ 100000 nM	Poor binder
T62184	GABA transporter GAT-1	BO0UY4	1-[2-[9-(4-Methoxyphenyl)fluoren-9-yl]oxyethyl]piperidine-3-carboxylic Acid	Investigative	10072112	C28H29NO4	443.5	COC1=CC=C(C=C1)C2(C3=CC=CC=C3C4=CC=CC=C42)OCCN5CCCC(C5)C(=O)O	IC50 = 132000 nM	Poor binder
T62184	GABA transporter GAT-1	BPA2B9	2,4-Dichloro-N-[1-(quinolin-2-ylmethyl)piperidin-4-yl]benzamide	Investigative	137659917	C22H21Cl2N3O	414.3	C1CN(CCC1NC(=O)C2=C(C=C(C=C2)Cl)Cl)CC3=NC4=CC=CC=C4C=C3	IC50 ~ 50000 nM	Poor binder
T62184	GABA transporter GAT-1	BQL41T	1-[4,4-Bis[3-(propan-2-yloxymethyl)thiophen-2-yl]but-3-enyl]piperidine-4-carboxylic acid;hydrochloride	Investigative	45265824	C26H38ClNO4S2	528.2	CC(C)OCC1=C(SC=C1)C(=CCCN2CCC(CC2)C(=O)O)C3=C(C=CS3)COC(C)C.Cl	IC50 ~ 100000 nM	Poor binder
T62184	GABA transporter GAT-1	BQN0U5	1-[4,4-Bis[3-(propan-2-yloxymethyl)thiophen-2-yl]but-3-enyl]piperidine-2-carboxylic acid;hydrochloride	Investigative	45263318	C26H38ClNO4S2	528.2	CC(C)OCC1=C(SC=C1)C(=CCCN2CCCCC2C(=O)O)C3=C(C=CS3)COC(C)C.Cl	IC50 ~ 100000 nM	Poor binder
T62184	GABA transporter GAT-1	BS13ZC	1-[4,4-Bis[3-(methoxymethyl)thiophen-2-yl]but-3-enyl]piperidine-4-carboxylic acid;hydrochloride	Investigative	45263312	C22H30ClNO4S2	472.1	COCC1=C(SC=C1)C(=CCCN2CCC(CC2)C(=O)O)C3=C(C=CS3)COC.Cl	IC50 ~ 100000 nM	Poor binder
T62184	GABA transporter GAT-1	BS65TV	(1S,2S)-2-Aminocyclopropane-1-acetic acid	Investigative	55285850	C5H9NO2	115.13	C1[C@H]([C@H]1N)CC(=O)O	IC50 ~ 100000 nM	Poor binder
T62184	GABA transporter GAT-1	BXG3Y0	2,4-Dichloro-N-[1-[(4-nitrophenyl)methyl]piperidin-4-yl]benzamide	Investigative	137638595	C19H19Cl2N3O3	408.3	C1CN(CCC1NC(=O)C2=C(C=C(C=C2)Cl)Cl)CC3=CC=C(C=C3)[N+](=O)[O-]	IC50 ~ 100000 nM	Poor binder
T62184	GABA transporter GAT-1	D0H7WK	SNAP-5114	Investigative	10458835	C30H35NO6	505.6	COC1=CC=C(C=C1)C(C2=CC=C(C=C2)OC)(C3=CC=C(C=C3)OC)OCCN4CCC[C@@H](C4)C(=O)O	IC50 ~ 100000 nM	Poor binder
T62184	GABA transporter GAT-1	D0V5OY	N-(1-benzylpiperidine-4-yl)-2-naphthamide	Investigative	16725912	C23H24N2O	344.4	C1CN(CCC1NC(=O)C2=CC3=CC=CC=C3C=C2)CC4=CC=CC=C4	Ki ~ 100000 nM	Poor binder