TTD_Target_ID	Target_Name	TTD_Drug_ID	Drug_Name	Drug_Highest_Status	Drug_PubchemID	Molecular_Formula	Molecular_Weight	Canonical_SMILES	Activity	Binder_Type
T62431	Tyrosine-protein kinase SYK	B0WV4G	p38 MAP Kinase Inhibitor IX	Investigative	16730109	C22H17N7O2	411.4	CC1=C(C=C(C=C1)C(=O)NC2=NOC=C2)NC3=C4C=NN(C4=NC=N3)C5=CC=CC=C5	IC50 ~ 50000 nM	Poor binder
T62431	Tyrosine-protein kinase SYK	B1ZK8C	(4E)-4-{[5-(2-Chlorophenyl)furan-2-yl]methylidene}-1-phenylpyrazolidine-3,5-dione	Investigative	2241431	C20H13ClN2O3	364.8	C1=CC=C(C=C1)N2C(=O)/C(=C/C3=CC=C(O3)C4=CC=CC=C4Cl)/C(=O)N2	IC50 = 57000 nM	Poor binder
T62431	Tyrosine-protein kinase SYK	B2WPO5	2-[4-(4-{2-[(5-Carboxy-pentyl)-(5-methyl-hexyl)-sulfamoyl]-vinyl}-phenylcarbamoyl)-cyclohex-1-enyl]-malonic acid	Investigative	10995725	C31H44N2O9S	620.8	CC(C)CCCCN(CCCCCC(=O)O)S(=O)(=O)/C=C/C1=CC=C(C=C1)NC(=O)C2CCC(=CC2)C(C(=O)O)C(=O)O	IC50 = 71000 nM	Poor binder
T62431	Tyrosine-protein kinase SYK	B5IC7N	(4R)-4-[(1S)-1-[(7-Phenyl-1,6-naphthyridin-5-yl)oxy]ethyl]pyrrolidin-2-one	Investigative	58071971	C20H19N3O2	333.4	C[C@@H]([C@@H]1CC(=O)NC1)OC2=C3C=CC=NC3=CC(=N2)C4=CC=CC=C4	IC50 ~ 100000 nM	Poor binder
T62431	Tyrosine-protein kinase SYK	B5MV1N	3-(2,5-Dihydroxy-benzylamino)-N-phenethyl-benzamide	Investigative	10044189	C22H22N2O3	362.4	C1=CC=C(C=C1)CCNC(=O)C2=CC(=CC=C2)NCC3=C(C=CC(=C3)O)O	IC50 ~ 100000 nM	Poor binder
T62431	Tyrosine-protein kinase SYK	B5WQR4	(S)-4-{(S)-2-[(S)-2-Acetylamino-3-(4-phosphonooxy-phenyl)-propionylamino]-4-carboxy-butyrylamino}-4-((1S,2S)-1-carbamoyl-2-methyl-butylcarbamoyl)-butyric acid	Investigative	44315963	C27H40N5O13P	673.6	CC[C@H](C)[C@@H](C(=O)N)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC1=CC=C(C=C1)OP(=O)(O)O)NC(=O)C	IC50 = 171000 nM	Poor binder
T62431	Tyrosine-protein kinase SYK	B74GBS	6-(2-Aminoethoxy)-4-(5,6-dimethylpyridin-2-ylamino)pyridazine-3-carboxamide	Investigative	73777169	C14H18N6O2	302.33	CC1=C(N=C(C=C1)NC2=CC(=NN=C2C(=O)N)OCCN)C	IC50 ~ 50118.72 nM	Poor binder
T62431	Tyrosine-protein kinase SYK	B7I6VY	4-Chloro-3-(pyridin-2-ylmethoxy)aniline	Investigative	64008775	C12H11ClN2O	234.68	C1=CC=NC(=C1)COC2=C(C=CC(=C2)N)Cl	IC50 = 50118.72 nM	Poor binder
T62431	Tyrosine-protein kinase SYK	B93ILO	9H-Imidazo(4,5-H)isoquinolin-9-one, 2-((2,6-dichlorophenyl)amino)-1,8-dihydro-6,7-dimethyl-	Investigative	10248747	C18H14Cl2N4O	373.2	CC1=C(NC(=O)C2=C1C=CC3=C2N=C(N3)NC4=C(C=CC=C4Cl)Cl)C	IC50 ~ 100000 nM	Poor binder
T62431	Tyrosine-protein kinase SYK	B9A7KF	N-Tert-butyl-2-(6-chloro-1-methylindazol-3-yl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxamide	Investigative	71279444	C19H19ClN6O	382.8	CC(C)(C)NC(=O)C1=CNC2=NC=C(N=C12)C3=NN(C4=C3C=CC(=C4)Cl)C	IC50 ~ 50000 nM	Poor binder
T62431	Tyrosine-protein kinase SYK	B9OES1	1-(3-(8-(Pyridin-4-ylmethylamino)imidazo[1,2-a]pyrazin-6-yl)phenyl)-3-(3-(trifluoromethyl)phenyl)urea	Investigative	11755812	C26H20F3N7O	503.5	C1=CC(=CC(=C1)NC(=O)NC2=CC=CC(=C2)C(F)(F)F)C3=CN4C=CN=C4C(=N3)NCC5=CC=NC=C5	IC50 = 50000 nM	Poor binder
T62431	Tyrosine-protein kinase SYK	BATN08	N-Dodecyl-5-(2,5-dihydroxybenzylamino)-2-hydroxybenzamide	Investigative	10343317	C26H38N2O4	442.6	CCCCCCCCCCCCNC(=O)C1=C(C=CC(=C1)NCC2=C(C=CC(=C2)O)O)O	IC50 = 50000 nM	Poor binder
T62431	Tyrosine-protein kinase SYK	BD7SX4	5-(2,5-Dihydroxy-benzylamino)-2-hydroxy-N-[2-(4-methoxy-phenyl)-ethyl]-benzamide	Investigative	10716388	C23H24N2O5	408.4	COC1=CC=C(C=C1)CCNC(=O)C2=C(C=CC(=C2)NCC3=C(C=CC(=C3)O)O)O	IC50 = 50000 nM	Poor binder
T62431	Tyrosine-protein kinase SYK	BEZQ59	(4S)-4-[[(2S)-2-[[2-[[4-[3-[[2-[[(2S)-2-[[2-[[(2S,3R)-2-[[(2S)-2-Acetamido-3-(4-phosphonooxyphenyl)propanoyl]amino]-3-hydroxybutanoyl]amino]acetyl]amino]-4-methylpentanoyl]amino]acetyl]amino]prop-1-ynyl]benzoyl]amino]acetyl]amino]-3-(4-phosphonooxyphenyl)propanoyl]amino]-5-[[(2S,3R)-1-[[(2S)-1-amino-4-methyl-1-oxopentan-2-yl]amino]-3-hydroxy-1-oxobutan-2-yl]amino]-5-oxopentanoic acid	Investigative	56675134	C61H84N12O24P2	1431.3	C[C@H]([C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC1=CC=C(C=C1)OP(=O)(O)O)NC(=O)CNC(=O)C2=CC=C(C=C2)C#CCNC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CC3=CC=C(C=C3)OP(=O)(O)O)NC(=O)C)O	IC50 = 62000 nM	Poor binder
T62431	Tyrosine-protein kinase SYK	BFW63Z	6-Fluoro-2-isopropyl-4-(5-methyl-1H-pyrazol-3-ylamino)phthalazin-1(2H)-one	Investigative	11565679	C15H16FN5O	301.32	CC1=CC(=NN1)NC2=NN(C(=O)C3=C2C=C(C=C3)F)C(C)C	IC50 = 87500 nM	Poor binder
T62431	Tyrosine-protein kinase SYK	BK2GQ1	N-Benzyl-N-methyl-4-(phenylsulfamoyl)benzamide	Investigative	27666048	C21H20N2O3S	380.5	CN(CC1=CC=CC=C1)C(=O)C2=CC=C(C=C2)S(=O)(=O)NC3=CC=CC=C3	IC50 ~ 100000 nM	Poor binder
T62431	Tyrosine-protein kinase SYK	BN3Y0E	3-[[5-Cyano-6-(cyclopentylamino)pyrimidin-4-yl]amino]-4-methyl-N-(1,2-oxazol-3-yl)benzamide	Investigative	11235063	C21H21N7O2	403.4	CC1=C(C=C(C=C1)C(=O)NC2=NOC=C2)NC3=C(C(=NC=N3)NC4CCCC4)C#N	IC50 ~ 50000 nM	Poor binder
T62431	Tyrosine-protein kinase SYK	BQX9A6	N-Cyclopropyl-2,4-difluoro-5-((2-(pyridin-2-ylamino)thiazol-5-yl)methylamino)benzamide	Investigative	11632737	C19H17F2N5OS	401.4	C1CC1NC(=O)C2=CC(=C(C=C2F)F)NCC3=CN=C(S3)NC4=CC=CC=N4	IC50 ~ 50000 nM	Poor binder
T62431	Tyrosine-protein kinase SYK	BRL56D	5-Amino-1-(2-fluorophenyl)-N-(5-(isoxazol-3-ylcarbamoyl)-2-methylphenyl)-1H-pyrazole-4-carboxamide	Investigative	49838879	C21H17FN6O3	420.4	CC1=C(C=C(C=C1)C(=O)NC2=NOC=C2)NC(=O)C3=C(N(N=C3)C4=CC=CC=C4F)N	IC50 ~ 50000 nM	Poor binder
T62431	Tyrosine-protein kinase SYK	BS51CB	1-(2-Chlorobenzyl)-3-(5-oxo-2-thioxotetrahydro-4H-imidazol-4-yliden)-1H-indol-2-one	Investigative	135548971	C18H12ClN3O2S	369.8	C1=CC=C(C(=C1)CN2C3=CC=CC=C3C(=C2O)C4=NC(=S)NC4=O)Cl	IC50 = 168000 nM	Poor binder
T62431	Tyrosine-protein kinase SYK	BUC3S5	N-(2-Methoxy-4-morpholinophenyl)-N'-cyclohexyl-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine	Investigative	121320416	C23H30N6O2	422.5	COC1=C(C=CC(=C1)N2CCOCC2)NC3=NC4=C(C=CN4)C(=N3)NC5CCCCC5	IC50 = 153000 nM	Poor binder
T62431	Tyrosine-protein kinase SYK	BUWR06	Chembl4283270	Investigative	145982265	C21H19NO3	333.4	CC(=O)C1=CC(=C(C=C1)OCC2=CC=CC=N2)C3=CC=C(C=C3)OC	IC50 ~ 50118.72 nM	Poor binder
T62431	Tyrosine-protein kinase SYK	BVI90B	Chembl4276946	Investigative	134611886	C12H11Cl2N3O	284.14	CC1=NN(C(=C1C2=CC(=C(C=C2)Cl)Cl)N)C(=O)C	IC50 ~ 100000 nM	Poor binder
T62431	Tyrosine-protein kinase SYK	BVK1Y3	7-(3,4-Dimethoxyphenyl)-3-methyl-5-[[(2R)-3,3,3-trifluoro-2-hydroxypropyl]amino]pyrido[4,3-d]pyrimidin-4-one	Investigative	58093197	C19H19F3N4O4	424.4	CN1C=NC2=CC(=NC(=C2C1=O)NC[C@H](C(F)(F)F)O)C3=CC(=C(C=C3)OC)OC	IC50 ~ 50000 nM	Poor binder
T62431	Tyrosine-protein kinase SYK	BX5DY4	2-[4-(4-{2-[(5-Carboxy-pentyl)-(5-methyl-hexyl)-sulfamoyl]-vinyl}-phenylcarbamoyl)-cyclohexyl]-malonic acid	Investigative	10941165	C31H46N2O9S	622.8	CC(C)CCCCN(CCCCCC(=O)O)S(=O)(=O)/C=C/C1=CC=C(C=C1)NC(=O)C2CCC(CC2)C(C(=O)O)C(=O)O	IC50 = 63000 nM	Poor binder
T62431	Tyrosine-protein kinase SYK	D04PEI	BMS-509744	Investigative	11467730	C32H41N5O4S2	623.8	CC1=CC(=C(C=C1SC2=CN=C(S2)NC(=O)C3=CC=C(C=C3)CNC(C)C(C)(C)C)C(=O)N4CCN(CC4)C(=O)C)OC	IC50 ~ 50000 nM	Poor binder
T62431	Tyrosine-protein kinase SYK	D0O9UR	2-methoxy-4-(2-nitrovinyl)phenol	Investigative	638439	C9H9NO4	195.17	COC1=C(C=CC(=C1)/C=C/[N+](=O)[O-])O	IC50 = 76000 nM	Poor binder
T62431	Tyrosine-protein kinase SYK	D0T3PW	Myricetin	Investigative	5281672	C15H10O8	318.23	C1=C(C=C(C(=C1O)O)O)C2=C(C(=O)C3=C(C=C(C=C3O2)O)O)O	EC50 = 54000 nM	Poor binder