TTD_Target_ID	Target_Name	TTD_Drug_ID	Drug_Name	Drug_Highest_Status	Drug_PubchemID	Molecular_Formula	Molecular_Weight	Canonical_SMILES	Activity	Binder_Type
T63967	Neuronal acetylcholine receptor alpha-4/beta-2	D0K0KH	Tropisetron	Approved	656665	C17H20N2O2	284.35	CN1[C@@H]2CC[C@H]1CC(C2)OC(=O)C3=CNC4=CC=CC=C43	Ki = 55000 nM	Poor binder
T63967	Neuronal acetylcholine receptor alpha-4/beta-2	D0K7WK	Ondansetron	Approved	4595	C18H19N3O	293.4	CC1=NC=CN1CC2CCC3=C(C2=O)C4=CC=CC=C4N3C	IC50 = 66000 nM	Poor binder
T63967	Neuronal acetylcholine receptor alpha-4/beta-2	D0Q9HF	Acetylcholine	Approved	187	C7H16NO2+	146.21	CC(=O)OCC[N+](C)(C)C	EC50 = 70000 nM	Poor binder
T63967	Neuronal acetylcholine receptor alpha-4/beta-2	B0EI1H	(1R,4R)-2-[5-Hydroxy-3-pyridinyl]-2,5-diazabicyclo[2.2.1]-heptane	Investigative	10198017	C10H13N3O	191.23	C1C2CNC1CN2C3=CC(=CN=C3)O	EC50 ~ 100000 nM	Poor binder
T63967	Neuronal acetylcholine receptor alpha-4/beta-2	B0PD5Z	2-[4-(4-Fluorophenyl)sulfonylpiperazin-1-yl]-N-(1H-pyrazol-5-yl)acetamide	Investigative	56926498	C15H18FN5O3S	367.4	C1CN(CCN1CC(=O)NC2=CC=NN2)S(=O)(=O)C3=CC=C(C=C3)F	IC50 ~ 100000 nM	Poor binder
T63967	Neuronal acetylcholine receptor alpha-4/beta-2	B0PKX8	(3R)-N-(6-Methylpyrimidin-4-yl)spiro[1-azabicyclo[2.2.2]octane-3,5'-4H-1,3-oxazole]-2'-amine	Investigative	137649484	C14H19N5O	273.33	CC1=CC(=NC=N1)NC2=NC[C@]3(O2)CN4CCC3CC4	EC50 ~ 100000 nM	Poor binder
T63967	Neuronal acetylcholine receptor alpha-4/beta-2	B14CFB	N-(1H-Pyrazol-5-yl)-2-(4-pyridin-3-ylsulfonylpiperazin-1-yl)acetamide	Investigative	56926723	C14H18N6O3S	350.4	C1CN(CCN1CC(=O)NC2=CC=NN2)S(=O)(=O)C3=CN=CC=C3	IC50 = 83000 nM	Poor binder
T63967	Neuronal acetylcholine receptor alpha-4/beta-2	B1H0ZR	N-(6-Chloropyridin-2-yl)-4-propoxybenzamide	Investigative	71727772	C15H15ClN2O2	290.74	CCCOC1=CC=C(C=C1)C(=O)NC2=NC(=CC=C2)Cl	IC50 ~ 100000 nM	Poor binder
T63967	Neuronal acetylcholine receptor alpha-4/beta-2	B1TZJ3	Dianicline	Investigative	10176764	C13H16N2O	216.28	C1CN2CC[C@@]3(C2)[C@H]1OC4=C(C3)N=CC=C4	EC50 ~ 100000 nM	Poor binder
T63967	Neuronal acetylcholine receptor alpha-4/beta-2	B20HDJ	2-(6-Chloropyridin-3-yl)-2,7-diazaspiro[4.4]nonane	Investigative	22291236	C12H16ClN3	237.73	C1CNCC12CCN(C2)C3=CN=C(C=C3)Cl	EC50 ~ 100000 nM	Poor binder
T63967	Neuronal acetylcholine receptor alpha-4/beta-2	B20WLE	N-[6-(3-Fluoroanilino)pyridin-2-yl]-4-propoxybenzamide	Investigative	71727900	C21H20FN3O2	365.4	CCCOC1=CC=C(C=C1)C(=O)NC2=CC=CC(=N2)NC3=CC(=CC=C3)F	IC50 ~ 100000 nM	Poor binder
T63967	Neuronal acetylcholine receptor alpha-4/beta-2	B2I6CX	2-(2-Methyl-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrol-5-yl)xanthen-9-one	Investigative	11461365	C20H20N2O2	320.4	CN1CC2CN(CC2C1)C3=CC4=C(C=C3)OC5=CC=CC=C5C4=O	EC50 ~ 100000 nM	Poor binder
T63967	Neuronal acetylcholine receptor alpha-4/beta-2	B2MHT9	N-(6-Anilinopyridin-2-yl)-4-propoxybenzamide	Investigative	71727898	C21H21N3O2	347.4	CCCOC1=CC=C(C=C1)C(=O)NC2=CC=CC(=N2)NC3=CC=CC=C3	IC50 ~ 100000 nM	Poor binder
T63967	Neuronal acetylcholine receptor alpha-4/beta-2	B2P6QG	(1S,2R,4S)-N-(Isoquinolin-3-yl)-4'H-4-azaspiro[bicyclo[2.2.2]octane-2,5'-oxazol]-2'-amine	Investigative	44247585	C18H20N4O	308.4	C1CN2CCC1[C@@]3(C2)CN=C(O3)NC4=CC5=CC=CC=C5C=N4	EC50 ~ 100000 nM	Poor binder
T63967	Neuronal acetylcholine receptor alpha-4/beta-2	B2VB8U	(3R)-N-(5-Methylpyrazin-2-yl)spiro[1-azabicyclo[2.2.2]octane-3,5'-4H-1,3-oxazole]-2'-amine	Investigative	58081856	C14H19N5O	273.33	CC1=CN=C(C=N1)NC2=NC[C@]3(O2)CN4CCC3CC4	EC50 ~ 100000 nM	Poor binder
T63967	Neuronal acetylcholine receptor alpha-4/beta-2	B34HMC	5-(3,7-Diazabicyclo[3.3.1]nonane-3-carbonyl)furan-3-carbonitrile	Investigative	68024620	C13H15N3O2	245.28	C1C2CNCC1CN(C2)C(=O)C3=CC(=CO3)C#N	EC50 = 110000 nM	Poor binder
T63967	Neuronal acetylcholine receptor alpha-4/beta-2	B38UAB	4-[[2-[4-(2-Fluorophenyl)sulfonylpiperazin-1-yl]acetyl]amino]benzoic acid	Investigative	56926617	C19H20FN3O5S	421.4	C1CN(CCN1CC(=O)NC2=CC=C(C=C2)C(=O)O)S(=O)(=O)C3=CC=CC=C3F	IC50 ~ 100000 nM	Poor binder
T63967	Neuronal acetylcholine receptor alpha-4/beta-2	B3AGF6	(3R)-N-(5-Methoxypyrazin-2-yl)spiro[1-azabicyclo[2.2.2]octane-3,5'-4H-1,3-oxazole]-2'-amine	Investigative	137660090	C14H19N5O2	289.33	COC1=NC=C(N=C1)NC2=NC[C@]3(O2)CN4CCC3CC4	EC50 ~ 100000 nM	Poor binder
T63967	Neuronal acetylcholine receptor alpha-4/beta-2	B3NGV4	(3Ar,6aS)-5-(6-phenylpyridazin-3-yl)-2,3,3a,4,6,6a-hexahydro-1H-pyrrolo[3,4-c]pyrrole;2,2,2-trifluoroacetic acid	Investigative	44592633	C18H19F3N4O2	380.4	C1[C@@H]2CN(C[C@@H]2CN1)C3=NN=C(C=C3)C4=CC=CC=C4.C(=O)(C(F)(F)F)O	EC50 ~ 100000 nM	Poor binder
T63967	Neuronal acetylcholine receptor alpha-4/beta-2	B46SDE	(3R)-N-(6-Propan-2-ylpyrimidin-4-yl)spiro[1-azabicyclo[2.2.2]octane-3,5'-4H-1,3-oxazole]-2'-amine	Investigative	137633214	C16H23N5O	301.39	CC(C)C1=CC(=NC=N1)NC2=NC[C@]3(O2)CN4CCC3CC4	EC50 ~ 100000 nM	Poor binder
T63967	Neuronal acetylcholine receptor alpha-4/beta-2	B4CT7F	2-(6-Bromo-2-propyl-1H-indol-3-yl)-N-methylethanamine	Investigative	56594105	C14H19BrN2	295.22	CCCC1=C(C2=C(N1)C=C(C=C2)Br)CCNC	EC50 = 72443.6 nM	Poor binder
T63967	Neuronal acetylcholine receptor alpha-4/beta-2	B4EF2W	3,7-Diazabicyclo[3.3.1]nonan-3-yl(phenyl)methanone	Investigative	18177037	C14H18N2O	230.31	C1C2CNCC1CN(C2)C(=O)C3=CC=CC=C3	EC50 = 100000 nM	Poor binder
T63967	Neuronal acetylcholine receptor alpha-4/beta-2	B52KGQ	1-Ethyl-4-phenylthiomorpholin-1-ium;trifluoromethanesulfonate	Investigative	137637992	C13H18F3NO3S2	357.4	CC[S+]1CCN(CC1)C2=CC=CC=C2.C(F)(F)(F)S(=O)(=O)[O-]	IC50 = 51000 nM	Poor binder
T63967	Neuronal acetylcholine receptor alpha-4/beta-2	B5D3EM	3-(Dimethylamino)butyl 3-methylazetidine-1-carboxylate;oxalic acid	Investigative	49859909	C13H24N2O6	304.34	CC1CN(C1)C(=O)OCCC(C)N(C)C.C(=O)(C(=O)O)O	EC50 = 85000 nM	Poor binder
T63967	Neuronal acetylcholine receptor alpha-4/beta-2	B5FQV1	CID 52920236	Investigative	52920236	C19H21N5O	335.4	C1CN2CCC1[C@@]3(C2)CN=C(O3)NC4=NC=NC(=C4)C5=CC=CC=C5	EC50 ~ 100000 nM	Poor binder
T63967	Neuronal acetylcholine receptor alpha-4/beta-2	B5LWF2	1-Isopropylpiperidin-4-one oxime	Investigative	7172378	C8H16N2O	156.23	CC(C)N1CCC(=NO)CC1	Ki ~ 100000 nM	Poor binder
T63967	Neuronal acetylcholine receptor alpha-4/beta-2	B67SLP	(2E)-1-[(4-Azidopyridin-3-yl)methyl]-N-nitro-1,3-dihydro-2H-imidazol-2-imine	Investigative	11086486	C9H8N8O2	260.209	C1=CN=CC(=C1N=[N+]=[N-])CN2C=CN=C2N[N+](=O)[O-]	Ki = 95800 nM	Poor binder
T63967	Neuronal acetylcholine receptor alpha-4/beta-2	B6DLS9	7-(6-Chloropyridin-3-yl)-1,7-diazaspiro[4.4]nonane	Investigative	11715647	C12H16ClN3	237.73	C1CC2(CCN(C2)C3=CN=C(C=C3)Cl)NC1	EC50 ~ 100000 nM	Poor binder
T63967	Neuronal acetylcholine receptor alpha-4/beta-2	B6L4QY	N-Pyrimidin-4-ylspiro[1-azabicyclo[2.2.2]octane-3,5'-4H-1,3-oxazole]-2'-amine	Investigative	137635141	C13H17N5O	259.31	C1CN2CCC1C3(C2)CN=C(O3)NC4=NC=NC=C4	EC50 ~ 100000 nM	Poor binder
T63967	Neuronal acetylcholine receptor alpha-4/beta-2	B6SQ3H	Phantasmidine	Investigative	45379093	C11H11ClN2O	222.67	C1C[C@]23[C@H]1NC[C@H]2C4=C(O3)N=C(C=C4)Cl	EC50 = 56000 nM	Poor binder
T63967	Neuronal acetylcholine receptor alpha-4/beta-2	B7K9GP	Polygodial	Investigative	72503	C15H22O2	234.33	C[C@]12CCCC([C@@H]1CC=C([C@@H]2C=O)C=O)(C)C	IC50 = 62500 nM	Poor binder
T63967	Neuronal acetylcholine receptor alpha-4/beta-2	B7Y1GK	2-Pyridin-3-yl-2,7-diazaspiro[4.4]nonane	Investigative	10262309	C12H17N3	203.28	C1CNCC12CCN(C2)C3=CN=CC=C3	EC50 ~ 100000 nM	Poor binder
T63967	Neuronal acetylcholine receptor alpha-4/beta-2	B82AGI	4-Chlorobenzoic acid [(2S)-1-methylpyrrolidine-2-yl]methyl ester	Investigative	73348844	C13H16ClNO2	253.72	CN1CCC[C@H]1COC(=O)C2=CC=C(C=C2)Cl	IC50 = 95000 nM	Poor binder
T63967	Neuronal acetylcholine receptor alpha-4/beta-2	B9VEY0	(3R)-N-(4-Propan-2-ylpyrimidin-2-yl)spiro[1-azabicyclo[2.2.2]octane-3,5'-4H-1,3-oxazole]-2'-amine	Investigative	137655697	C16H23N5O	301.39	CC(C)C1=NC(=NC=C1)NC2=NC[C@]3(O2)CN4CCC3CC4	EC50 ~ 100000 nM	Poor binder
T63967	Neuronal acetylcholine receptor alpha-4/beta-2	BA0O3M	N-[6-(Pentylamino)pyridin-2-yl]-4-propoxybenzamide	Investigative	71727896	C20H27N3O2	341.4	CCCCCNC1=NC(=CC=C1)NC(=O)C2=CC=C(C=C2)OCCC	IC50 ~ 100000 nM	Poor binder
T63967	Neuronal acetylcholine receptor alpha-4/beta-2	BA35PX	(R)-N-(5-Chloropyrazin-2-yl)-4H-1'-azaspiro[oxazole-5,3'-bicyclo[2.2.2]octan]-2-amine	Investigative	52920234	C13H16ClN5O	293.75	C1CN2CCC1[C@@]3(C2)CN=C(O3)NC4=CN=C(C=N4)Cl	EC50 ~ 100000 nM	Poor binder
T63967	Neuronal acetylcholine receptor alpha-4/beta-2	BB7Y1T	(R)-N-(6-Methoxypyrimidin-4-yl)-4H-1'-azaspiro[oxazole-5,3'-bicyclo[2.2.2]octan]-2-amine	Investigative	52920232	C14H19N5O2	289.33	COC1=NC=NC(=C1)NC2=NC[C@]3(O2)CN4CCC3CC4	EC50 ~ 100000 nM	Poor binder
T63967	Neuronal acetylcholine receptor alpha-4/beta-2	BBLE37	Varenicline	Investigative	170361	C13H13N3	211.26	C1C2CNCC1C3=CC4=NC=CN=C4C=C23	IC50 = 50000 nM	Poor binder
T63967	Neuronal acetylcholine receptor alpha-4/beta-2	BBO7Z1	(3R)-N-(6-Chloropyrimidin-4-yl)spiro[1-azabicyclo[2.2.2]octane-3,5'-4H-1,3-oxazole]-2'-amine	Investigative	137660174	C13H16ClN5O	293.75	C1CN2CCC1[C@@]3(C2)CN=C(O3)NC4=CC(=NC=N4)Cl	EC50 ~ 100000 nM	Poor binder
T63967	Neuronal acetylcholine receptor alpha-4/beta-2	BBV1E8	N-(6-Bromopyridin-2-yl)-4-prop-2-enoxybenzamide	Investigative	47461992	C15H13BrN2O2	333.18	C=CCOC1=CC=C(C=C1)C(=O)NC2=NC(=CC=C2)Br	IC50 = 70100 nM	Poor binder
T63967	Neuronal acetylcholine receptor alpha-4/beta-2	BC06YI	3-(Cyclobutylmethoxy)-5-(2-phenylethynyl)pyridine	Investigative	72712462	C18H17NO	263.3	C1CC(C1)COC2=CN=CC(=C2)C#CC3=CC=CC=C3	Ki ~ 100000 nM	Poor binder
T63967	Neuronal acetylcholine receptor alpha-4/beta-2	BCK4E8	(3R)-N-Pyrimidin-5-ylspiro[1-azabicyclo[2.2.2]octane-3,5'-4H-1,3-oxazole]-2'-amine	Investigative	137654434	C13H17N5O	259.31	C1CN2CCC1[C@@]3(C2)CN=C(O3)NC4=CN=CN=C4	EC50 ~ 100000 nM	Poor binder
T63967	Neuronal acetylcholine receptor alpha-4/beta-2	BDOT63	2-[5-[[(2S)-Pyrrolidin-2-yl]methoxy]pyridin-3-yl]-1,3-dihydroisoindole;hydrochloride	Investigative	52948803	C18H22ClN3O	331.8	C1C[C@H](NC1)COC2=CN=CC(=C2)N3CC4=CC=CC=C4C3.Cl	IC50 ~ 100000 nM	Poor binder
T63967	Neuronal acetylcholine receptor alpha-4/beta-2	BDTG17	(3R)-N-(5-Phenylpyrazin-2-yl)spiro[1-azabicyclo[2.2.2]octane-3,5'-4H-1,3-oxazole]-2'-amine	Investigative	137654242	C19H21N5O	335.4	C1CN2CCC1[C@@]3(C2)CN=C(O3)NC4=NC=C(N=C4)C5=CC=CC=C5	EC50 ~ 100000 nM	Poor binder
T63967	Neuronal acetylcholine receptor alpha-4/beta-2	BE5Z9R	(4-Chlorofuran-2-yl)-(3,7-diazabicyclo[3.3.1]nonan-3-yl)methanone	Investigative	59268918	C12H15ClN2O2	254.71	C1C2CNCC1CN(C2)C(=O)C3=CC(=CO3)Cl	EC50 = 100000 nM	Poor binder
T63967	Neuronal acetylcholine receptor alpha-4/beta-2	BEI4K8	N-[6-(4-Chloroanilino)pyridin-2-yl]-4-propoxybenzamide	Investigative	71728020	C21H20ClN3O2	381.9	CCCOC1=CC=C(C=C1)C(=O)NC2=CC=CC(=N2)NC3=CC=C(C=C3)Cl	IC50 ~ 100000 nM	Poor binder
T63967	Neuronal acetylcholine receptor alpha-4/beta-2	BET93F	2-[4-(2-Fluorophenyl)sulfonylpiperazin-1-yl]-N-(1H-pyrazol-5-yl)acetamide	Investigative	56926722	C15H18FN5O3S	367.4	C1CN(CCN1CC(=O)NC2=CC=NN2)S(=O)(=O)C3=CC=CC=C3F	IC50 ~ 100000 nM	Poor binder
T63967	Neuronal acetylcholine receptor alpha-4/beta-2	BETD61	(3R)-N-(5-Methoxypyrimidin-2-yl)spiro[1-azabicyclo[2.2.2]octane-3,5'-4H-1,3-oxazole]-2'-amine	Investigative	137644928	C14H19N5O2	289.33	COC1=CN=C(N=C1)NC2=NC[C@]3(O2)CN4CCC3CC4	EC50 ~ 100000 nM	Poor binder
T63967	Neuronal acetylcholine receptor alpha-4/beta-2	BEU60O	N-[6-(Butylamino)pyridin-2-yl]-4-propoxybenzamide	Investigative	71727895	C19H25N3O2	327.4	CCCCNC1=NC(=CC=C1)NC(=O)C2=CC=C(C=C2)OCCC	IC50 = 54100 nM	Poor binder
T63967	Neuronal acetylcholine receptor alpha-4/beta-2	BF37WA	5-[[(2S)-1-Methylpyrrolidin-2-yl]methoxy]pyridin-3-ol	Investigative	122185338	C11H16N2O2	208.26	CN1CCC[C@H]1COC2=CN=CC(=C2)O	EC50 = 73000 nM	Poor binder
T63967	Neuronal acetylcholine receptor alpha-4/beta-2	BFH0C8	(3-Chlorofuran-2-yl)-(3,7-diazabicyclo[3.3.1]nonan-3-yl)methanone	Investigative	24945300	C12H15ClN2O2	254.71	C1C2CNCC1CN(C2)C(=O)C3=C(C=CO3)Cl	EC50 = 76000 nM	Poor binder
T63967	Neuronal acetylcholine receptor alpha-4/beta-2	BFZ9H2	3-Phenyl-5-(1-(piperidin-4-yl)-1H-pyrazol-4-yl)isoxazole	Investigative	44580284	C17H18N4O	294.35	C1CNCCC1N2C=C(C=N2)C3=CC(=NO3)C4=CC=CC=C4	EC50 = 100000 nM	Poor binder
T63967	Neuronal acetylcholine receptor alpha-4/beta-2	BG18OB	(3R)-N-(1,7-Naphthyridin-6-yl)spiro[1-azabicyclo[2.2.2]octane-3,5'-4H-1,3-oxazole]-2'-amine	Investigative	137659736	C17H19N5O	309.4	C1CN2CCC1[C@@]3(C2)CN=C(O3)NC4=NC=C5C(=C4)C=CC=N5	EC50 ~ 100000 nM	Poor binder
T63967	Neuronal acetylcholine receptor alpha-4/beta-2	BGH80W	3,5,5-Trimethyl-2-(pyridin-3-yl)morpholin-2-ol	Investigative	49799236	C12H18N2O2	222.28	CC1C(OCC(N1)(C)C)(C2=CN=CC=C2)O	IC50 ~ 100000 nM	Poor binder
T63967	Neuronal acetylcholine receptor alpha-4/beta-2	BGR3E1	N-(4-Methoxyphenyl)-2-(4-pyridin-3-ylsulfonylpiperazin-1-yl)acetamide	Investigative	39010244	C18H22N4O4S	390.5	COC1=CC=C(C=C1)NC(=O)CN2CCN(CC2)S(=O)(=O)C3=CN=CC=C3	IC50 ~ 100000 nM	Poor binder
T63967	Neuronal acetylcholine receptor alpha-4/beta-2	BH5UI3	Trimethyl-[[1-[(1-methylpyridin-1-ium-3-yl)methyl]indol-3-yl]methyl]azanium;diiodide	Investigative	76325731	C19H25I2N3	549.2	C[N+]1=CC=CC(=C1)CN2C=C(C3=CC=CC=C32)C[N+](C)(C)C.[I-].[I-]	IC50 ~ 100000 nM	Poor binder
T63967	Neuronal acetylcholine receptor alpha-4/beta-2	BH6IB2	N-(6-Chloropyridin-2-yl)-4-prop-2-enoxybenzamide	Investigative	71727769	C15H13ClN2O2	288.73	C=CCOC1=CC=C(C=C1)C(=O)NC2=NC(=CC=C2)Cl	IC50 ~ 100000 nM	Poor binder
T63967	Neuronal acetylcholine receptor alpha-4/beta-2	BH9B6C	(3R)-N-Pyrazin-2-ylspiro[1-azabicyclo[2.2.2]octane-3,5'-4H-1,3-oxazole]-2'-amine	Investigative	137657023	C13H17N5O	259.31	C1CN2CCC1[C@@]3(C2)CN=C(O3)NC4=NC=CN=C4	EC50 ~ 100000 nM	Poor binder
T63967	Neuronal acetylcholine receptor alpha-4/beta-2	BJ5VE7	(3R)-N-(5-Methylpyrimidin-2-yl)spiro[1-azabicyclo[2.2.2]octane-3,5'-4H-1,3-oxazole]-2'-amine	Investigative	137635902	C14H19N5O	273.33	CC1=CN=C(N=C1)NC2=NC[C@]3(O2)CN4CCC3CC4	EC50 ~ 100000 nM	Poor binder
T63967	Neuronal acetylcholine receptor alpha-4/beta-2	BK53FO	CID 58088118	Investigative	58088118	C14H18N4O	258.32	C1CN2CCC1[C@@]3(C2)CN=C(O3)NC4=CC=CC=N4	EC50 ~ 100000 nM	Poor binder
T63967	Neuronal acetylcholine receptor alpha-4/beta-2	BL9B3C	(3R)-N-(4-Methylpyrimidin-2-yl)spiro[1-azabicyclo[2.2.2]octane-3,5'-4H-1,3-oxazole]-2'-amine	Investigative	137647317	C14H19N5O	273.33	CC1=NC(=NC=C1)NC2=NC[C@]3(O2)CN4CCC3CC4	EC50 ~ 100000 nM	Poor binder
T63967	Neuronal acetylcholine receptor alpha-4/beta-2	BLP30N	3-(1,4-Diazabicyclo[3.2.2]nonane-4-yl)dibenzothiophene 5,5-dioxide	Investigative	57334716	C19H20N2O2S	340.4	C1CN2CCC1N(CC2)C3=CC4=C(C=C3)C5=CC=CC=C5S4(=O)=O	EC50 ~ 100000 nM	Poor binder
T63967	Neuronal acetylcholine receptor alpha-4/beta-2	BML9B7	(R)-N-(5-m-Tolylpyrimidin-2-yl)-4H-1'-azaspiro[oxazole-5,3'-bicyclo[2.2.2]octan]-2-amine	Investigative	58081870	C20H23N5O	349.4	CC1=CC(=CC=C1)C2=CN=C(N=C2)NC3=NC[C@]4(O3)CN5CCC4CC5	EC50 ~ 100000 nM	Poor binder
T63967	Neuronal acetylcholine receptor alpha-4/beta-2	BMOH90	(3Ar,6aS)-5-(5-phenylpyridin-3-yl)-2,3,3a,4,6,6a-hexahydro-1H-pyrrolo[3,4-c]pyrrole;2,2,2-trifluoroacetic acid	Investigative	44592539	C19H20F3N3O2	379.4	C1[C@@H]2CN(C[C@@H]2CN1)C3=CN=CC(=C3)C4=CC=CC=C4.C(=O)(C(F)(F)F)O	EC50 ~ 100000 nM	Poor binder
T63967	Neuronal acetylcholine receptor alpha-4/beta-2	BMU41A	1-[3-(Dimethylamino)propyl]-2-oxo-4-phenylquinoline-3-carbonitrile	Investigative	23332842	C21H21N3O	331.4	CN(C)CCCN1C2=CC=CC=C2C(=C(C1=O)C#N)C3=CC=CC=C3	EC50 ~ 100000 nM	Poor binder
T63967	Neuronal acetylcholine receptor alpha-4/beta-2	BMX5B2	N-[6-(Hexylamino)pyridin-2-yl]-4-propoxybenzamide	Investigative	71727897	C21H29N3O2	355.5	CCCCCCNC1=NC(=CC=C1)NC(=O)C2=CC=C(C=C2)OCCC	IC50 ~ 100000 nM	Poor binder
T63967	Neuronal acetylcholine receptor alpha-4/beta-2	BN07RM	3-(3-(Dimethylamino)butyl)-1,1-dimethylurea	Investigative	44570098	C9H21N3O	187.28	CC(CCNC(=O)N(C)C)N(C)C	Ki = 100000 nM	Poor binder
T63967	Neuronal acetylcholine receptor alpha-4/beta-2	BN7D6E	(3R)-N-(4-Methoxypyrimidin-2-yl)spiro[1-azabicyclo[2.2.2]octane-3,5'-4H-1,3-oxazole]-2'-amine	Investigative	137649905	C14H19N5O2	289.33	COC1=NC(=NC=C1)NC2=NC[C@]3(O2)CN4CCC3CC4	EC50 ~ 100000 nM	Poor binder
T63967	Neuronal acetylcholine receptor alpha-4/beta-2	BNS60U	(3R)-N-(6-Methylpyrazin-2-yl)spiro[1-azabicyclo[2.2.2]octane-3,5'-4H-1,3-oxazole]-2'-amine	Investigative	137645815	C14H19N5O	273.33	CC1=CN=CC(=N1)NC2=NC[C@]3(O2)CN4CCC3CC4	EC50 ~ 100000 nM	Poor binder
T63967	Neuronal acetylcholine receptor alpha-4/beta-2	BO5A9Q	Desformylflustrabromine	Investigative	637026	C16H21BrN2	321.25	CC(C)(C=C)C1=C(C2=C(N1)C=C(C=C2)Br)CCNC	IC50 = 150000 nM	Poor binder
T63967	Neuronal acetylcholine receptor alpha-4/beta-2	BPF83H	2,3,3a,4,6,6a-Hexahydro-1H-pyrrolo[3,4-c]pyrrol-5-yl-(4-phenoxyphenyl)methanone	Investigative	71451944	C19H20N2O2	308.4	C1C2CN(CC2CN1)C(=O)C3=CC=C(C=C3)OC4=CC=CC=C4	EC50 = 51000 nM	Poor binder
T63967	Neuronal acetylcholine receptor alpha-4/beta-2	BPV89L	1-[5-[[(2S)-Pyrrolidin-2-yl]methoxy]pyridin-3-yl]piperazine;hydrochloride	Investigative	52945135	C14H23ClN4O	298.81	C1C[C@H](NC1)COC2=CN=CC(=C2)N3CCNCC3.Cl	IC50 ~ 100000 nM	Poor binder
T63967	Neuronal acetylcholine receptor alpha-4/beta-2	BQ2FC1	(3R)-N-(4-Phenylpyrimidin-2-yl)spiro[1-azabicyclo[2.2.2]octane-3,5'-4H-1,3-oxazole]-2'-amine	Investigative	137660214	C19H21N5O	335.4	C1CN2CCC1[C@@]3(C2)CN=C(O3)NC4=NC=CC(=N4)C5=CC=CC=C5	EC50 ~ 100000 nM	Poor binder
T63967	Neuronal acetylcholine receptor alpha-4/beta-2	BQ8FG7	[1-[(3-Hydroxyphenyl)methyl]indol-3-yl]methyl-trimethylazanium;iodide	Investigative	76322102	C19H23IN2O	422.3	C[N+](C)(C)CC1=CN(C2=CC=CC=C21)CC3=CC(=CC=C3)O.[I-]	Ki = 112000 nM	Poor binder
T63967	Neuronal acetylcholine receptor alpha-4/beta-2	BR7EK6	N-[6-(4-Fluoroanilino)pyridin-2-yl]-4-propoxybenzamide	Investigative	71727901	C21H20FN3O2	365.4	CCCOC1=CC=C(C=C1)C(=O)NC2=CC=CC(=N2)NC3=CC=C(C=C3)F	IC50 ~ 100000 nM	Poor binder
T63967	Neuronal acetylcholine receptor alpha-4/beta-2	BRF3D5	CID 58088056	Investigative	58088056	C17H19N5O	309.4	C1CN2CCC1[C@@]3(C2)CN=C(O3)NC4=NC5=CC=CC=C5C=N4	EC50 ~ 100000 nM	Poor binder
T63967	Neuronal acetylcholine receptor alpha-4/beta-2	BRM3E9	3-[[(2S)-Azetidin-2-yl]methoxy]-5-hex-1-ynyl-2-(trifluoromethyl)pyridine	Investigative	71584827	C16H19F3N2O	312.33	CCCCC#CC1=CC(=C(N=C1)C(F)(F)F)OC[C@@H]2CCN2	Ki ~ 100000 nM	Poor binder
T63967	Neuronal acetylcholine receptor alpha-4/beta-2	BS2WB7	N-[6-(4-Methoxyanilino)pyridin-2-yl]-4-propoxybenzamide	Investigative	71728021	C22H23N3O3	377.4	CCCOC1=CC=C(C=C1)C(=O)NC2=CC=CC(=N2)NC3=CC=C(C=C3)OC	IC50 ~ 100000 nM	Poor binder
T63967	Neuronal acetylcholine receptor alpha-4/beta-2	BS6VY1	(3R)-N-(3-Methylpyrazin-2-yl)spiro[1-azabicyclo[2.2.2]octane-3,5'-4H-1,3-oxazole]-2'-amine	Investigative	137644763	C14H19N5O	273.33	CC1=NC=CN=C1NC2=NC[C@]3(O2)CN4CCC3CC4	EC50 ~ 100000 nM	Poor binder
T63967	Neuronal acetylcholine receptor alpha-4/beta-2	BT7PS4	(3R)-N-Pyrimidin-2-ylspiro[1-azabicyclo[2.2.2]octane-3,5'-4H-1,3-oxazole]-2'-amine	Investigative	137659815	C13H17N5O	259.31	C1CN2CCC1[C@@]3(C2)CN=C(O3)NC4=NC=CC=N4	EC50 ~ 100000 nM	Poor binder
T63967	Neuronal acetylcholine receptor alpha-4/beta-2	BTW79U	N-(6-Bromopyridin-2-yl)-4-propoxybenzamide	Investigative	71727771	C15H15BrN2O2	335.2	CCCOC1=CC=C(C=C1)C(=O)NC2=NC(=CC=C2)Br	IC50 = 80700 nM	Poor binder
T63967	Neuronal acetylcholine receptor alpha-4/beta-2	BV0E5X	N-(6-Piperidin-1-ylpyridin-2-yl)-4-propoxybenzamide	Investigative	71728023	C20H25N3O2	339.4	CCCOC1=CC=C(C=C1)C(=O)NC2=NC(=CC=C2)N3CCCCC3	IC50 ~ 100000 nM	Poor binder
T63967	Neuronal acetylcholine receptor alpha-4/beta-2	BV2UL1	3,5,5-Trimethyl-2-(pyridin-2-yl)morpholin-2-ol	Investigative	49799237	C12H18N2O2	222.28	CC1C(OCC(N1)(C)C)(C2=CC=CC=N2)O	IC50 ~ 100000 nM	Poor binder
T63967	Neuronal acetylcholine receptor alpha-4/beta-2	BW94OH	2-(2,3,3a,4,6,6a-Hexahydro-1H-pyrrolo[3,4-c]pyrrole-5-carbonyl)furan-3-carbonitrile	Investigative	68024616	C12H13N3O2	231.25	C1C2CN(CC2CN1)C(=O)C3=C(C=CO3)C#N	EC50 = 100000 nM	Poor binder
T63967	Neuronal acetylcholine receptor alpha-4/beta-2	BX6KB4	5'-Phenylspiro[1-azabicyclo[2.2.2]octane-3,2'-3H-furo[2,3-b]pyridine]	Investigative	10085732	C19H20N2O	292.4	C1CN2CCC1C3(C2)CC4=C(O3)N=CC(=C4)C5=CC=CC=C5	EC50 ~ 100000 nM	Poor binder
T63967	Neuronal acetylcholine receptor alpha-4/beta-2	BY7JG4	N-Pyrazin-2-ylspiro[1-azabicyclo[2.2.2]octane-3,5'-4H-1,3-oxazole]-2'-amine	Investigative	137643408	C13H17N5O	259.31	C1CN2CCC1C3(C2)CN=C(O3)NC4=NC=CN=C4	EC50 ~ 100000 nM	Poor binder
T63967	Neuronal acetylcholine receptor alpha-4/beta-2	BY8V5O	N-[6-(2-Fluoroanilino)pyridin-2-yl]-4-propoxybenzamide	Investigative	71727899	C21H20FN3O2	365.4	CCCOC1=CC=C(C=C1)C(=O)NC2=CC=CC(=N2)NC3=CC=CC=C3F	IC50 ~ 100000 nM	Poor binder
T63967	Neuronal acetylcholine receptor alpha-4/beta-2	BZ3HW7	N-[6-(Benzylamino)pyridin-2-yl]-4-propoxybenzamide	Investigative	71728022	C22H23N3O2	361.4	CCCOC1=CC=C(C=C1)C(=O)NC2=CC=CC(=N2)NCC3=CC=CC=C3	IC50 ~ 100000 nM	Poor binder
T63967	Neuronal acetylcholine receptor alpha-4/beta-2	BZA25R	A-582941 Free base	Investigative	44190553	C17H20N4	280.37	CN1C[C@@H]2CN(C[C@@H]2C1)C3=NN=C(C=C3)C4=CC=CC=C4	Ki ~ 100000 nM	Poor binder
T63967	Neuronal acetylcholine receptor alpha-4/beta-2	BZUD98	3,7-Diazabicyclo[3.3.1]nonan-3-yl-[(1R,2S)-2-methylcyclopropyl]methanone	Investigative	73347561	C12H20N2O	208.3	C[C@H]1C[C@H]1C(=O)N2CC3CC(C2)CNC3	EC50 = 100000 nM	Poor binder
T63967	Neuronal acetylcholine receptor alpha-4/beta-2	D03JPN	A-582941	Investigative	11173546	C17H20N4	280.37	CN1CC2CN(CC2C1)C3=NN=C(C=C3)C4=CC=CC=C4	Ki ~ 100000 nM	Poor binder
T63967	Neuronal acetylcholine receptor alpha-4/beta-2	D06FLU	3,8-dibromoboldine	Investigative	10480509	C19H19Br2NO4	485.2	CN1CCC2=C3[C@@H]1CC4=C(C(=C(C=C4C3=C(C(=C2Br)O)OC)OC)O)Br	IC50 = 101000 nM	Poor binder
T63967	Neuronal acetylcholine receptor alpha-4/beta-2	D09BSE	3-bromoboldine	Investigative	10409038	C19H20BrNO4	406.3	CN1CCC2=C3[C@@H]1CC4=CC(=C(C=C4C3=C(C(=C2Br)O)OC)OC)O	IC50 = 99000 nM	Poor binder