TTD_Target_ID	Target_Name	TTD_Drug_ID	Drug_Name	Drug_Highest_Status	Drug_PubchemID	Molecular_Formula	Molecular_Weight	Canonical_SMILES	Activity	Binder_Type
T65889	Pyruvate kinase M2	B17ZVL	6-Nitro-[3,3'-ethylenebis(1H-indole)]	Investigative	91827688	C18H15N3O2	305.3	C1=CC=C2C(=C1)C(=CN2)CCC3=CNC4=C3C=CC(=C4)[N+](=O)[O-]	IC50 = 54600 nM	Poor binder
T65889	Pyruvate kinase M2	B7UG4N	2-(1H-1,2,4-Triazol-3-yl)-3a,4,7,7a-tetrahydro-1H-4,7-methanoisoindole-1,3-dione	Investigative	3245674	C11H10N4O2	230.22	C1C2C=CC1C3C2C(=O)N(C3=O)C4=NC=NN4	IC50 = 90000 nM	Poor binder
T65889	Pyruvate kinase M2	B9CAN1	8-Methyl-2-[1-(propan-2-ylamino)ethenyl]thieno[3,2-c]chromen-4-one	Investigative	91667626	C17H17NO2S	299.4	CC1=CC2=C(C=C1)OC(=O)C3=C2SC(=C3)C(=C)NC(C)C	IC50 = 70000 nM	Poor binder
T65889	Pyruvate kinase M2	BD32BG	2-Chloro-5-(2,5-dimethyl-pyrrol-1-yl)-benzoic acid	Investigative	776842	C13H12ClNO2	249.69	CC1=CC=C(N1C2=CC(=C(C=C2)Cl)C(=O)O)C	IC50 ~ 100000 nM	Poor binder
T65889	Pyruvate kinase M2	BGIX79	5-(2,5-Dimethyl-pyrrol-1-yl)-2-hydroxy-benzoic acid	Investigative	776870	C13H13NO3	231.25	CC1=CC=C(N1C2=CC(=C(C=C2)O)C(=O)O)C	IC50 = 100000 nM	Poor binder
T65889	Pyruvate kinase M2	BKA8Y2	1-[4-(2,5-Dimethylpyrrol-1-yl)phenyl]sulfanylpropan-2-one	Investigative	91667624	C15H17NOS	259.399	CC1=CC=C(N1C2=CC=C(C=C2)SCC(=O)C)C	IC50 = 90000 nM	Poor binder
T65889	Pyruvate kinase M2	D00LMG	SCUTELLAREIN	Investigative	5281697	C15H10O6	286.24	C1=CC(=CC=C1C2=CC(=O)C3=C(O2)C=C(C(=C3O)O)O)O	IC50 = 100000 nM	Poor binder