TTD_Target_ID	Target_Name	TTD_Drug_ID	Drug_Name	Drug_Highest_Status	Drug_PubchemID	Molecular_Formula	Molecular_Weight	Canonical_SMILES	Activity	Binder_Type
T66237	Vasopressin V2 receptor	D08ORO	OPC-21268	Discontinued in Phase 2	114904	C26H31N3O4	449.5	CC(=O)NCCCOC1=CC=C(C=C1)C(=O)N2CCC(CC2)N3C(=O)CCC4=CC=CC=C43	Ki ~ 81000 nM	Poor binder
T66237	Vasopressin V2 receptor	B1OY2B	Vasopressin antagonist 1867	Investigative	11677610	C28H36N4O4	492.6	CC(C)NC(=O)CN1C(=NC2=C(C1=O)C=C(C=C2)OCCCN3CCCCC3)C4=CC(=CC=C4)OC	IC50 ~ 100000 nM	Poor binder
T66237	Vasopressin V2 receptor	B8UKC7	Tetra-iodophenolphthalein	Investigative	71720517	C20H10I4O4	821.9	C1=CC=C2C(=C1)C(=O)OC2(C3=CC(=C(C(=C3)I)O)I)C4=C(C=C(C=C4I)O)I	IC50 = 50118.72 nM	Poor binder
T66237	Vasopressin V2 receptor	BE8I7P	Dilithium;2-(3-amino-6-imino-5-sulfo-4-sulfonatoxanthen-9-yl)-5-[[(5S)-5-[[(2S)-1-[(4R,7S,10S,13S,16S)-7-(2-amino-2-oxoethyl)-13-benzyl-16-[(4-hydroxyphenyl)methyl]-10-(2-methylpropyl)-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentazacycloicosane-4-carbonyl]pyrrolidine-2-carbonyl]amino]-6-(carboxymethylamino)-6-oxohexyl]carbamoyl]benzoate	Investigative	118705579	C68H76Li2N12O22S4	1555.6	[Li+].[Li+].CC(C)C[C@H]1C(=O)N[C@H](C(=O)N[C@@H](CSSCCC(=O)N[C@H](C(=O)N[C@H](C(=O)N1)CC2=CC=CC=C2)CC3=CC=C(C=C3)O)C(=O)N4CCC[C@H]4C(=O)N[C@@H](CCCCNC(=O)C5=CC(=C(C=C5)C6=C7C=CC(=N)C(=C7OC8=C6C=CC(=C8S(=O)(=O)[O-])N)S(=O)(=O)O)C(=O)[O-])C(=O)NCC(=O)O)CC(=O)N	Ki ~ 100000 nM	Poor binder
T66237	Vasopressin V2 receptor	BFQ32P	2-(2-(3-Chlorophenyl)-4-oxo-6-(3-(piperidin-1-yl)propoxy)quinazolin-3(4H)-yl)-N-isopropylacetamide	Investigative	11854507	C27H33ClN4O3	497	CC(C)NC(=O)CN1C(=NC2=C(C1=O)C=C(C=C2)OCCCN3CCCCC3)C4=CC(=CC=C4)Cl	IC50 ~ 100000 nM	Poor binder
T66237	Vasopressin V2 receptor	BGSU98	CID 11569672	Investigative	11569672	C30H40N4O3	504.7	CC(C)C[C@@H]1C(=O)N[C@@H](C(=O)N1[C@H](C2=CC=C(C=C2)N(C)C)C(=O)NC(C)C)C3CC4=CC=CC=C4C3	Ki ~ 79432.82 nM	Poor binder
T66237	Vasopressin V2 receptor	BLI4R6	N-(Cyclopropylmethyl)-2-[6-(3-morpholin-4-ylpropoxy)-4-oxo-2-phenylquinazolin-3-yl]acetamide	Investigative	46934434	C27H32N4O4	476.6	C1CC1CNC(=O)CN2C(=NC3=C(C2=O)C=C(C=C3)OCCCN4CCOCC4)C5=CC=CC=C5	IC50 ~ 100000 nM	Poor binder
T66237	Vasopressin V2 receptor	BS6PH2	Dilithium;3-amino-9-[4-[[(5S)-5-[[(2S)-1-[(4R,7S,10S,13S,16S)-7-(2-amino-2-oxoethyl)-13-benzyl-19-hydroxy-16-[(4-hydroxyphenyl)methyl]-10-(2-methylpropyl)-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentazacycloicosane-4-carbonyl]pyrrolidine-2-carbonyl]amino]-6-(carboxymethylamino)-6-oxohexyl]carbamoyl]-2-carboxyphenyl]-6-iminoxanthene-4,5-disulfonate	Investigative	118705580	C68H76Li2N12O23S4	1571.6	[Li+].[Li+].CC(C)C[C@H]1C(=O)N[C@H](C(=O)N[C@@H](CSSCC(C(=O)N[C@H](C(=O)N[C@H](C(=O)N1)CC2=CC=CC=C2)CC3=CC=C(C=C3)O)O)C(=O)N4CCC[C@H]4C(=O)N[C@@H](CCCCNC(=O)C5=CC(=C(C=C5)C6=C7C=CC(=N)C(=C7OC8=C6C=CC(=C8S(=O)(=O)[O-])N)S(=O)(=O)[O-])C(=O)O)C(=O)NCC(=O)O)CC(=O)N	Ki ~ 100000 nM	Poor binder