TTD_Target_ID	Target_Name	TTD_Drug_ID	Drug_Name	Drug_Highest_Status	Drug_PubchemID	Molecular_Formula	Molecular_Weight	Canonical_SMILES	Activity	Binder_Type
T68163	Tyrosine-protein kinase Lyn	D0M9QZ	ABT-869	Phase 3	11485656	C21H18FN5O	375.4	CC1=CC(=C(C=C1)F)NC(=O)NC2=CC=C(C=C2)C3=C4C(=CC=C3)NN=C4N	IC50 ~ 50000 nM	Poor binder
T68163	Tyrosine-protein kinase Lyn	B0WLH8	N-(7-Methoxyquinolin-6-yl)thieno[3,2-d]pyrimidine-7-carboxamide	Investigative	58056356	C17H12N4O2S	336.4	COC1=C(C=C2C=CC=NC2=C1)NC(=O)C3=CSC4=CN=CN=C43	IC50 ~ 50000 nM	Poor binder
T68163	Tyrosine-protein kinase Lyn	B3T9QN	Methyl 4-(6-(4-(methoxycarbonylamino)phenyl)-4-morpholino-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidine-1-carboxylate	Investigative	44219749	C24H29N7O5	495.5	COC(=O)NC1=CC=C(C=C1)C2=NC3=C(C=NN3C4CCN(CC4)C(=O)OC)C(=N2)N5CCOCC5	IC50 ~ 50000 nM	Poor binder
T68163	Tyrosine-protein kinase Lyn	B43WPI	3-[(E)-2-(4-Chlorophenyl)ethenyl]-N-[(2R)-2,3-dihydroxypropyl]-4-methoxybenzamide	Investigative	57325478	C19H20ClNO4	361.8	COC1=C(C=C(C=C1)C(=O)NC[C@H](CO)O)/C=C/C2=CC=C(C=C2)Cl	IC50 ~ 50000 nM	Poor binder
T68163	Tyrosine-protein kinase Lyn	B4G2QZ	Methyl 4-(6-(4-aminophenyl)-4-morpholino-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidine-1-carboxylate	Investigative	44605035	C22H27N7O3	437.5	COC(=O)N1CCC(CC1)N2C3=C(C=N2)C(=NC(=N3)C4=CC=C(C=C4)N)N5CCOCC5	IC50 ~ 50000 nM	Poor binder
T68163	Tyrosine-protein kinase Lyn	B58TMC	[6-Chloro-4-methyl-3-[[3-(methylsulfamoylamino)phenyl]methyl]-2-oxochromen-7-yl] N,N-dimethylcarbamate	Investigative	24753787	C21H22ClN3O6S	479.9	CC1=C(C(=O)OC2=CC(=C(C=C12)Cl)OC(=O)N(C)C)CC3=CC(=CC=C3)NS(=O)(=O)NC	IC50 ~ 50000 nM	Poor binder
T68163	Tyrosine-protein kinase Lyn	B5ON0T	6-(1,9-Diazaspiro[5.5]undecan-9-Yl)-9h-Purine	Investigative	70789254	C14H20N6	272.35	C1CCNC2(C1)CCN(CC2)C3=NC=NC4=C3NC=N4	IC50 = 178000 nM	Poor binder
T68163	Tyrosine-protein kinase Lyn	B5QLX1	(E)-N-(4-Chloroimidazo[1,5-a]quinoxalin-8-yl)-4-(dimethylamino)-N-methylbut-2-enamide	Investigative	57401723	C17H18ClN5O	343.8	CN(C)C/C=C/C(=O)N(C)C1=CC2=C(C=C1)N=C(C3=CN=CN23)Cl	IC50 ~ 50000 nM	Poor binder
T68163	Tyrosine-protein kinase Lyn	B7N1WR	3-[(E)-2-(4-Chlorophenyl)ethenyl]-N-[(2S)-2,3-dihydroxypropyl]-4-methoxybenzamide	Investigative	57325479	C19H20ClNO4	361.8	COC1=C(C=C(C=C1)C(=O)NC[C@@H](CO)O)/C=C/C2=CC=C(C=C2)Cl	IC50 ~ 50000 nM	Poor binder
T68163	Tyrosine-protein kinase Lyn	BDAR08	3-[4-(3-Amino-7-methoxy-1,2-benzoxazol-4-yl)phenyl]-1-(3-chlorophenyl)urea	Investigative	11429729	C21H17ClN4O3	408.8	COC1=C2C(=C(C=C1)C3=CC=C(C=C3)NC(=O)NC4=CC(=CC=C4)Cl)C(=NO2)N	IC50 ~ 50000 nM	Poor binder
T68163	Tyrosine-protein kinase Lyn	BF5M6P	2-(2-Methoxy-ethoxy)-N-{3-[5-(3-phenoxy-prop-1-ynyl)-thiophen-3-yl]-2,4-dihydro-indeno[1,2-c]pyrazol-5-yl}-acetamide	Investigative	44440256	C28H25N3O4S	499.6	COCCOCC(=O)NC1=CC=CC2=C1CC3=C2NN=C3C4=CSC(=C4)C#CCOC5=CC=CC=C5	IC50 ~ 50000 nM	Poor binder
T68163	Tyrosine-protein kinase Lyn	BKQ0H4	2-(4-Methyl-piperazin-1-yl)-N-{3-[5-(3-phenoxy-prop-1-ynyl)-thiophen-3-yl]-2,4-dihydro-indeno[1,2-c]pyrazol-5-yl}-acetamide	Investigative	16747696	C30H29N5O2S	523.6	CN1CCN(CC1)CC(=O)NC2=CC=CC3=C2CC4=C3NN=C4C5=CSC(=C5)C#CCOC6=CC=CC=C6	IC50 ~ 50000 nM	Poor binder
T68163	Tyrosine-protein kinase Lyn	BMP0C7	Tert-Butyl 4-(6-(4-aminophenyl)-4-morpholino-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidine-1-carboxylate	Investigative	44605037	C25H33N7O3	479.6	CC(C)(C)OC(=O)N1CCC(CC1)N2C3=C(C=N2)C(=NC(=N3)C4=CC=C(C=C4)N)N5CCOCC5	IC50 ~ 50000 nM	Poor binder
T68163	Tyrosine-protein kinase Lyn	BMTS94	6-Methyl-4-(4-methyl-1H-indol-5-ylamino)-5-(3-(4-methylpiperazin-1-ylsulfonyl)styryl)nicotinonitrile	Investigative	45375866	C29H30N6O2S	526.7	CC1=C(C=CC2=C1C=CN2)NC3=C(C(=NC=C3C#N)C)/C=C/C4=CC(=CC=C4)S(=O)(=O)N5CCN(CC5)C	IC50 ~ 50000 nM	Poor binder
T68163	Tyrosine-protein kinase Lyn	BT2MA5	3-[4-(3-Amino-7-methoxy-1,2-benzoxazol-4-yl)phenyl]-1-[3-(trifluoromethyl)phenyl]urea	Investigative	11374110	C22H17F3N4O3	442.4	COC1=C2C(=C(C=C1)C3=CC=C(C=C3)NC(=O)NC4=CC=CC(=C4)C(F)(F)F)C(=NO2)N	IC50 ~ 50000 nM	Poor binder
T68163	Tyrosine-protein kinase Lyn	BUMJ54	4-(1H-Indole-4-ylamino)-5-[3-[2-(4-methylpiperazino)ethoxy]phenyl]pyridine-3-carbonitrile	Investigative	24865437	C27H28N6O	452.6	CN1CCN(CC1)CCOC2=CC=CC(=C2)C3=C(C(=CN=C3)C#N)NC4=CC=CC5=C4C=CN5	IC50 ~ 100000 nM	Poor binder
T68163	Tyrosine-protein kinase Lyn	BYHM49	Ethyl 3-oxo-3-[[3-[5-(3-phenoxyprop-1-ynyl)thiophen-3-yl]-1,4-dihydroindeno[1,2-c]pyrazol-5-yl]amino]propanoate	Investigative	44440261	C28H23N3O4S	497.6	CCOC(=O)CC(=O)NC1=CC=CC2=C1CC3=C2NN=C3C4=CSC(=C4)C#CCOC5=CC=CC=C5	IC50 ~ 50000 nM	Poor binder
T68163	Tyrosine-protein kinase Lyn	BYJ2X1	3-[4-(3-Amino-7-methoxy-1,2-benzoxazol-4-yl)phenyl]-1-(2-fluoro-5-methylphenyl)urea	Investigative	11429654	C22H19FN4O3	406.4	CC1=CC(=C(C=C1)F)NC(=O)NC2=CC=C(C=C2)C3=C4C(=C(C=C3)OC)ON=C4N	IC50 ~ 50000 nM	Poor binder