TTD_Target_ID	Target_Name	TTD_Drug_ID	Drug_Name	Drug_Highest_Status	Drug_PubchemID	Molecular_Formula	Molecular_Weight	Canonical_SMILES	Activity	Binder_Type
T68290	Cathepsin S	D0V3YT	BOCEPREVIR	Approved	10324367	C27H45N5O5	519.7	CC1([C@@H]2[C@H]1[C@H](N(C2)C(=O)[C@H](C(C)(C)C)NC(=O)NC(C)(C)C)C(=O)NC(CC3CCC3)C(=O)C(=O)N)C	IC50 ~ 100000 nM	Poor binder
T68290	Cathepsin S	D0X9CH	Telaprevir	Approved	3010818	C36H53N7O6	679.8	CCC[C@@H](C(=O)C(=O)NC1CC1)NC(=O)[C@@H]2[C@H]3CCC[C@H]3CN2C(=O)[C@H](C(C)(C)C)NC(=O)[C@H](C4CCCCC4)NC(=O)C5=NC=CN=C5	IC50 ~ 100000 nM	Poor binder
T68290	Cathepsin S	D01LNG	Balicatib	Discontinued in Phase 2	10201696	C23H33N5O2	411.5	CCCN1CCN(CC1)C2=CC=C(C=C2)C(=O)NC3(CCCCC3)C(=O)NCC#N	Ki = 65000 nM	Poor binder
T68290	Cathepsin S	B0AL7B	(2S)-N-[(2S)-1-Amino-1-oxo-3-phenylpropan-2-yl]-4-methyl-2-[[(1S)-2,2,2-trifluoro-1-[4-(4-methylsulfonylphenyl)phenyl]ethyl]amino]pentanamide	Investigative	16661682	C30H34F3N3O4S	589.7	CC(C)C[C@@H](C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N)N[C@@H](C2=CC=C(C=C2)C3=CC=C(C=C3)S(=O)(=O)C)C(F)(F)F	IC50 = 66656 nM	Poor binder
T68290	Cathepsin S	B0C5ED	Benzyl N-[(2S)-1-[[(2S)-1,6-diamino-1-oxohexan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]carbamate	Investigative	73348851	C23H30N4O4	426.5	C1=CC=C(C=C1)C[C@@H](C(=O)N[C@@H](CCCCN)C(=O)N)NC(=O)OCC2=CC=CC=C2	Ki = 56000 nM	Poor binder
T68290	Cathepsin S	B0LA8M	(2S)-2-[[2-(3,5-Dichlorophenyl)acetyl]amino]-3,3-dimethyl-N-[2-[[(E)-3-methylsulfonylprop-2-enyl]amino]-2-oxoethyl]butanamide	Investigative	118720237	C20H27Cl2N3O5S	492.4	CC(C)(C)[C@@H](C(=O)NCC(=O)NC/C=C/S(=O)(=O)C)NC(=O)CC1=CC(=CC(=C1)Cl)Cl	IC50 ~ 100000 nM	Poor binder
T68290	Cathepsin S	B0QM8N	(2S)-N-[(1S)-3-Amino-1-cyano-3-oxopropyl]-1-[4-(4-tert-butylphenyl)phenyl]sulfonylpyrrolidine-2-carboxamide	Investigative	127037715	C25H30N4O4S	482.6	CC(C)(C)C1=CC=C(C=C1)C2=CC=C(C=C2)S(=O)(=O)N3CCC[C@H]3C(=O)N[C@@H](CC(=O)N)C#N	IC50 ~ 50000 nM	Poor binder
T68290	Cathepsin S	B0RVC8	(1R,2R)-N-[(1R)-1-Cyanoethyl]-2-(8-fluoro-1,3,4,5-tetrahydropyrido[4,3-b]indole-2-carbonyl)cyclohexane-1-carboxamide	Investigative	60195904	C22H25FN4O2	396.5	C[C@H](C#N)NC(=O)[C@@H]1CCCC[C@H]1C(=O)N2CCC3=C(C2)C4=C(N3)C=CC(=C4)F	IC50 ~ 100000 nM	Poor binder
T68290	Cathepsin S	B1JTN5	(1R,2R)-N-[(1S)-1-Cyanoethyl]-2-(8-fluoro-1,3,4,5-tetrahydropyrido[4,3-b]indole-2-carbonyl)cyclohexane-1-carboxamide	Investigative	60195905	C22H25FN4O2	396.5	C[C@@H](C#N)NC(=O)[C@@H]1CCCC[C@H]1C(=O)N2CCC3=C(C2)C4=C(N3)C=CC(=C4)F	IC50 ~ 70000 nM	Poor binder
T68290	Cathepsin S	B1KJN5	(1r)-1-{[5-(4-Fluorophenyl)-1,3,4-oxadiazol-2-yl]methyl}-2,2-dimethylpropyl(1S)-1-[oxo(1h-pyrazol-5-ylamino)acetyl]pentylcarbamate	Investigative	10186046	C25H31FN6O5	514.5	CCCC[C@@H](C(=O)C(=O)NC1=CC=NN1)NC(=O)O[C@H](CC2=NN=C(O2)C3=CC=C(C=C3)F)C(C)(C)C	IC50 = 110000 nM	Poor binder
T68290	Cathepsin S	B1P9BU	N-[1-(Cyanomethylcarbamoyl)cyclohexyl]-4-(4-methylpiperazine-1-carbonyl)benzamide	Investigative	11517167	C22H29N5O3	411.5	CN1CCN(CC1)C(=O)C2=CC=C(C=C2)C(=O)NC3(CCCCC3)C(=O)NCC#N	Ki = 110000 nM	Poor binder
T68290	Cathepsin S	B20ZUP	5-((2,3-Dimethylphenoxy)methyl)-3-methyloxazolidin-2-one	Investigative	44426056	C13H17NO3	235.28	CC1=C(C(=CC=C1)OCC2CN(C(=O)O2)C)C	IC50 ~ 100000 nM	Poor binder
T68290	Cathepsin S	B2GLO1	2-[(2S)-2-[[(2S)-2-Cyclohexyl-2-(pyrazine-2-carbonylamino)acetyl]amino]-3,3-dimethylbutanoyl]-N-[1-(cyclopropylamino)-1,2-dioxohexan-3-yl]-2-azaspiro[3.5]nonane-3-carboxamide	Investigative	73348056	C37H55N7O6	693.9	CCCC(C(=O)C(=O)NC1CC1)NC(=O)C2C3(CCCCC3)CN2C(=O)[C@H](C(C)(C)C)NC(=O)[C@H](C4CCCCC4)NC(=O)C5=NC=CN=C5	IC50 ~ 100000 nM	Poor binder
T68290	Cathepsin S	B2VAN9	(3R,4R)-4-(2,3-Dimethylphenoxy)piperidin-3-ol	Investigative	13186896	C13H19NO2	221.29	CC1=C(C(=CC=C1)O[C@@H]2CCNC[C@H]2O)C	IC50 ~ 100000 nM	Poor binder
T68290	Cathepsin S	B4VL8N	3-[2-(3,5-Dichlorophenyl)-2-methylpropanoyl]-4-methoxy-N-[2-[[(E)-3-methylsulfonylprop-2-enyl]amino]-2-oxoethyl]benzamide	Investigative	118720236	C24H26Cl2N2O6S	541.4	CC(C)(C1=CC(=CC(=C1)Cl)Cl)C(=O)C2=C(C=CC(=C2)C(=O)NCC(=O)NC/C=C/S(=O)(=O)C)OC	IC50 ~ 100000 nM	Poor binder
T68290	Cathepsin S	B5I6RB	(2R)-2-Amino-N-[(1S,2S)-1-cyano-2-phenylcyclopropyl]-3-thiophen-2-ylpropanamide;2,2,2-trifluoroacetic acid	Investigative	49797572	C19H18F3N3O3S	425.4	C1[C@H]([C@@]1(C#N)NC(=O)[C@@H](CC2=CC=CS2)N)C3=CC=CC=C3.C(=O)(C(F)(F)F)O	IC50 ~ 50000 nM	Poor binder
T68290	Cathepsin S	B5T0WC	N-[2-(Cyanomethylamino)-2-oxoethyl]-3-[2-(3,5-dichlorophenyl)-2-methylpropanoyl]-4-[2-(dimethylamino)ethoxy]benzamide	Investigative	118720233	C25H28Cl2N4O4	519.4	CC(C)(C1=CC(=CC(=C1)Cl)Cl)C(=O)C2=C(C=CC(=C2)C(=O)NCC(=O)NCC#N)OCCN(C)C	IC50 ~ 100000 nM	Poor binder
T68290	Cathepsin S	B69UDS	Tert-butyl (2S)-2-[(cyanomethyl)carbamoyl]pyrrolidine-1-carboxylate	Investigative	11514361	C12H19N3O3	253.3	CC(C)(C)OC(=O)N1CCC[C@H]1C(=O)NCC#N	Ki ~ 100000 nM	Poor binder
T68290	Cathepsin S	B6K3XT	N-[(2S)-1-[[(1S)-1-Cyano-3-phenylpropyl]amino]-2,4-dimethyl-1-oxopentan-2-yl]morpholine-4-carboxamide	Investigative	11732127	C22H32N4O3	400.5	CC(C)C[C@@](C)(C(=O)N[C@@H](CCC1=CC=CC=C1)C#N)NC(=O)N2CCOCC2	IC50 = 76000 nM	Poor binder
T68290	Cathepsin S	B6K9SO	Ac-hPhe-Leu-(D)-Ala-LeuVSMe	Investigative	11613973	C29H46N4O6S	578.8	C[C@H](C(=O)N[C@@H](CC(C)C)/C=C/S(=O)(=O)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC1=CC=CC=C1)NC(=O)C	IC50 = 77000 nM	Poor binder
T68290	Cathepsin S	B6M4IT	(2E)-2-[(E)-1-Phenoxypropan-2-ylidenehydrazinylidene]-3-phenyl-1,3-thiazolidin-4-one	Investigative	71452029	C18H17N3O2S	339.4	C/C(=N\\N=C\\1/N(C(=O)CS1)C2=CC=CC=C2)/COC3=CC=CC=C3	IC50 ~ 100000 nM	Poor binder
T68290	Cathepsin S	B6Y8LN	(S)-Tert-Butyl (1-oxo-3-phenyl-1-(prop-2-yn-1-ylamino)propan-2-yl)carbamate	Investigative	11673861	C17H22N2O3	302.37	CC(C)(C)OC(=O)N[C@@H](CC1=CC=CC=C1)C(=O)NCC#C	Ki ~ 100000 nM	Poor binder
T68290	Cathepsin S	B81UVG	Succinamide peptidomimetic, 7	Investigative	23648362	C23H34FN3O3	419.5	C1CCC(CC1)C[C@@H](CC(=O)NCCNC2=CC=C(C=C2)F)C(=O)N3CCOCC3	Ki ~ 100000 nM	Poor binder
T68290	Cathepsin S	B8CV9U	Dipeptide-derived nitrile, 40	Investigative	11603305	C22H25N3O3	379.5	CC(C)(C)OC(=O)N[C@@H](CC1=CC=CC=C1C2=CC=CC=C2)C(=O)NCC#N	Ki ~ 100000 nM	Poor binder
T68290	Cathepsin S	B9OH0B	Phenylalanine derivative, 37	Investigative	11616689	C17H23N3O3	317.4	CC(C)(C)OC(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N(C)CC#N	Ki ~ 100000 nM	Poor binder
T68290	Cathepsin S	BAE10O	(2S)-2-(3,5-Dichlorophenyl)-N-[(3S)-1-[2-[[(E)-3-methylsulfonylprop-2-enyl]amino]-2-oxoethyl]-2-oxopyrrolidin-3-yl]butanamide	Investigative	118720239	C20H25Cl2N3O5S	490.4	CC[C@@H](C1=CC(=CC(=C1)Cl)Cl)C(=O)N[C@H]2CCN(C2=O)CC(=O)NC/C=C/S(=O)(=O)C	IC50 ~ 100000 nM	Poor binder
T68290	Cathepsin S	BB24YL	Phenylalanine derived allylamide, 55	Investigative	14308232	C17H24N2O3	304.4	CC(C)(C)OC(=O)N[C@@H](CC1=CC=CC=C1)C(=O)NCC=C	Ki ~ 100000 nM	Poor binder
T68290	Cathepsin S	BC2HK1	Tert-butyl N-[(2S)-1-oxo-1-(5-propan-2-yl-1,3,4-oxadiazol-2-yl)pentan-2-yl]carbamate	Investigative	44412340	C15H25N3O4	311.38	CCC[C@@H](C(=O)C1=NN=C(O1)C(C)C)NC(=O)OC(C)(C)C	Ki = 130000 nM	Poor binder
T68290	Cathepsin S	BDC9Z8	2-((2S,3S)-2-Acetoxy-4-oxo-azetidin-3-ylcarbamoyl)-pyrrolidine-1-carboxylic acid benzyl ester	Investigative	44304591	C18H21N3O6	375.4	CC(=O)O[C@H]1[C@@H](C(=O)N1)NC(=O)C2CCCN2C(=O)OCC3=CC=CC=C3	Ki ~ 150000 nM	Poor binder
T68290	Cathepsin S	BE0MT1	(1R,2R)-N-[(1S)-1-Cyano-2,2-dimethylpropyl]-2-(8-fluoro-1,3,4,5-tetrahydropyrido[4,3-b]indole-2-carbonyl)cyclohexane-1-carboxamide	Investigative	60195906	C25H31FN4O2	438.5	CC(C)(C)[C@@H](C#N)NC(=O)[C@@H]1CCCC[C@H]1C(=O)N2CCC3=C(C2)C4=C(N3)C=CC(=C4)F	IC50 ~ 100000 nM	Poor binder
T68290	Cathepsin S	BE6I2L	Benzyl 1-((cyanomethyl)carbamoyl)cyclopropylcarbamate	Investigative	11680631	C14H15N3O3	273.29	C1CC1(C(=O)NCC#N)NC(=O)OCC2=CC=CC=C2	Ki ~ 150000 nM	Poor binder
T68290	Cathepsin S	BER0H1	(1R,2R)-N-(1-Cyanocyclopropyl)-2-[4-(6-methylsulfonyl-1,3-benzothiazol-2-yl)piperazine-1-carbonyl]cyclohexane-1-carboxamide	Investigative	70276990	C24H29N5O4S2	515.7	CS(=O)(=O)C1=CC2=C(C=C1)N=C(S2)N3CCN(CC3)C(=O)[C@@H]4CCCC[C@H]4C(=O)NC5(CC5)C#N	IC50 ~ 100000 nM	Poor binder
T68290	Cathepsin S	BF9C4I	(3S,4R)-4-(2,3-Dimethylphenoxy)piperidin-3-ol	Investigative	6917747	C13H19NO2	221.29	CC1=C(C(=CC=C1)O[C@@H]2CCNC[C@@H]2O)C	IC50 ~ 100000 nM	Poor binder
T68290	Cathepsin S	BFXT28	N-[2-(Cyanomethylamino)-2-oxoethyl]-3-[2-(3,5-dichlorophenyl)-2-methylpropanoyl]-4-methoxybenzamide	Investigative	118720232	C22H21Cl2N3O4	462.3	CC(C)(C1=CC(=CC(=C1)Cl)Cl)C(=O)C2=C(C=CC(=C2)C(=O)NCC(=O)NCC#N)OC	IC50 ~ 100000 nM	Poor binder
T68290	Cathepsin S	BG3O2I	N-[1-(Cyanomethylcarbamoyl)cyclohexyl]-4-(2-piperidin-4-yloxy-1,3-thiazol-4-yl)benzamide	Investigative	11605163	C24H29N5O3S	467.6	C1CCC(CC1)(C(=O)NCC#N)NC(=O)C2=CC=C(C=C2)C3=CSC(=N3)OC4CCNCC4	Ki = 68000 nM	Poor binder
T68290	Cathepsin S	BG9A4X	Benzyl N-[(2S)-1-(cyanomethylamino)-3,3-dimethyl-1-oxobutan-2-yl]carbamate	Investigative	11695166	C16H21N3O3	303.36	CC(C)(C)[C@@H](C(=O)NCC#N)NC(=O)OCC1=CC=CC=C1	Ki ~ 150000 nM	Poor binder
T68290	Cathepsin S	BIR0W4	(2E)-2-[(E)-1-Phenoxypropan-2-ylidenehydrazinylidene]-3-phenyl-5-propan-2-yl-1,3-thiazolidin-4-one	Investigative	71455561	C21H23N3O2S	381.5	CC(C)C1C(=O)N(/C(=N\\N=C(/C)\\COC2=CC=CC=C2)/S1)C3=CC=CC=C3	IC50 ~ 100000 nM	Poor binder
T68290	Cathepsin S	BJ4IA0	Succinamide peptidomimetic, 5	Investigative	23648361	C23H34FN3O3	419.5	C1CCC(CC1)C[C@@H](CC(=O)N2CCOCC2)C(=O)NCCNC3=CC=C(C=C3)F	Ki ~ 100000 nM	Poor binder
T68290	Cathepsin S	BLF0C6	N-[1-(Cyanomethylcarbamoyl)cyclohexyl]-4-(4-methylpiperazin-1-yl)sulfonylbenzamide	Investigative	11561418	C21H29N5O4S	447.6	CN1CCN(CC1)S(=O)(=O)C2=CC=C(C=C2)C(=O)NC3(CCCCC3)C(=O)NCC#N	Ki = 102000 nM	Poor binder
T68290	Cathepsin S	BM78SE	Benzyl 1-((cyanomethyl)carbamoyl)cyclopentylcarbamate	Investigative	11507712	C16H19N3O3	301.34	C1CCC(C1)(C(=O)NCC#N)NC(=O)OCC2=CC=CC=C2	Ki ~ 150000 nM	Poor binder
T68290	Cathepsin S	BMB1L4	(2S)-N-[(2S)-1-Amino-4-methylsulfanyl-1-oxobutan-2-yl]-4-methyl-2-[[(1S)-2,2,2-trifluoro-1-[4-(4-methylsulfonylphenyl)phenyl]ethyl]amino]pentanamide	Investigative	16661526	C26H34F3N3O4S2	573.7	CC(C)C[C@@H](C(=O)N[C@@H](CCSC)C(=O)N)N[C@@H](C1=CC=C(C=C1)C2=CC=C(C=C2)S(=O)(=O)C)C(F)(F)F	IC50 = 76938 nM	Poor binder
T68290	Cathepsin S	BNET60	Succinamide peptidomimetic, 38	Investigative	23648368	C27H31F6N3O4	575.5	CC(C)[C@@H](CNC1=CC=C(C=C1)OC(F)(F)F)NC(=O)[C@@H](CC(=O)N2CCOCC2)C3=CC=CC=C3C(F)(F)F	Ki ~ 100000 nM	Poor binder
T68290	Cathepsin S	BO2L1V	N-[(2S)-1-[[(1S)-1-Cyano-2,2-dimethylpropyl]amino]-4-methyl-1-oxopentan-2-yl]morpholine-4-carboxamide	Investigative	10860703	C17H30N4O3	338.4	CC(C)C[C@@H](C(=O)N[C@H](C#N)C(C)(C)C)NC(=O)N1CCOCC1	IC50 = 107000 nM	Poor binder
T68290	Cathepsin S	BOCP70	(2S)-2-[[(2S)-2-(3,5-Dichlorophenyl)-2-(ethylamino)acetyl]amino]-3,3-dimethyl-N-[2-[[(E)-3-methylsulfonylprop-2-enyl]amino]-2-oxoethyl]butanamide	Investigative	118720238	C22H32Cl2N4O5S	535.5	CCN[C@@H](C1=CC(=CC(=C1)Cl)Cl)C(=O)N[C@H](C(=O)NCC(=O)NC/C=C/S(=O)(=O)C)C(C)(C)C	IC50 ~ 100000 nM	Poor binder
T68290	Cathepsin S	BOZ8N7	(2E)-5-Ethyl-2-[(E)-1-phenoxypropan-2-ylidenehydrazinylidene]-3-phenyl-1,3-thiazolidin-4-one	Investigative	71452030	C20H21N3O2S	367.5	CCC1C(=O)N(/C(=N\\N=C(/C)\\COC2=CC=CC=C2)/S1)C3=CC=CC=C3	IC50 ~ 100000 nM	Poor binder
T68290	Cathepsin S	BP1FH9	[1-((3S,4R)-2-Oxo-4-phenoxy-azetidin-3-ylcarbamoyl)-cyclohexyl]-carbamic acid benzyl ester	Investigative	44304861	C24H27N3O5	437.5	C1CCC(CC1)(C(=O)N[C@H]2[C@H](NC2=O)OC3=CC=CC=C3)NC(=O)OCC4=CC=CC=C4	Ki = 53000 nM	Poor binder
T68290	Cathepsin S	BP36GN	Arylaminoethyl amide, 5q	Investigative	23648327	C23H26N4O3S	438.5	CC1=CC(=CC=C1)C(=O)N[C@@H](CC2=CN=CS2)C(=O)NCCNC3=CC=C(C=C3)OC	Ki ~ 65000 nM	Poor binder
T68290	Cathepsin S	BT5V2L	Phenylalanine derivative, 48	Investigative	11652420	C15H20N4O3	304.34	CC(C)(C)OC(=O)NN(CC1=CC=CC=C1)C(=O)NCC#N	Ki ~ 50000 nM	Poor binder
T68290	Cathepsin S	BTV6Z2	Morpholine-4-carboxylic acid [1-(1-cyano-3-phenyl-propylcarbamoyl)-ethyl]-amide	Investigative	11013354	C18H24N4O3	344.4	C[C@@H](C(=O)N[C@@H](CCC1=CC=CC=C1)C#N)NC(=O)N2CCOCC2	IC50 = 134000 nM	Poor binder
T68290	Cathepsin S	BU56EW	Ac-Glu(OtBu)-Ala-LeuVSMe	Investigative	11583999	C22H39N3O7S	489.6	C[C@@H](C(=O)N[C@@H](CC(C)C)/C=C/S(=O)(=O)C)NC(=O)[C@H](CCC(=O)OC(C)(C)C)NC(=O)C	IC50 = 170000 nM	Poor binder
T68290	Cathepsin S	BUG9I7	Aryl-morpholino-containing analogue, 13	Investigative	11501571	C20H26N4O3	370.4	C1CCC(CC1)(C(=O)NCC#N)NC(=O)C2=CC=C(C=C2)N3CCOCC3	IC50 = 52000 nM	Poor binder
T68290	Cathepsin S	BV5MK3	(2S)-N-[(1S)-3-Amino-1-cyano-3-oxopropyl]-1-(4-phenylphenyl)sulfonylpyrrolidine-2-carboxamide	Investigative	127042341	C21H22N4O4S	426.5	C1C[C@H](N(C1)S(=O)(=O)C2=CC=C(C=C2)C3=CC=CC=C3)C(=O)N[C@@H](CC(=O)N)C#N	IC50 ~ 50000 nM	Poor binder
T68290	Cathepsin S	BVP1Q6	(3S)-1-Diazo-3-[(aminoacetyl)amino]-4-(4-iodophenyl)-2-butanone	Investigative	102323332	C12H13IN4O2	372.16	C1=CC(=CC=C1C[C@@H](C(=O)C=[N+]=[N-])NC(=O)CN)I	IC50 ~ 50000 nM	Poor binder
T68290	Cathepsin S	BVR6L2	Ptosyl-NeopentylAsn-Ser-LeuVSMe	Investigative	11599767	C27H44N4O8S2	616.8	CC1=CC=C(C=C1)S(=O)(=O)N[C@@H](CC(=O)NCC(C)(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)/C=C/S(=O)(=O)C	IC50 ~ 150000 nM	Poor binder
T68290	Cathepsin S	BW4DQ9	(2S)-N-[(1S)-3-Amino-1-cyano-3-oxopropyl]-1-[4-(4-methoxyphenyl)phenyl]sulfonylpyrrolidine-2-carboxamide	Investigative	127042051	C22H24N4O5S	456.5	COC1=CC=C(C=C1)C2=CC=C(C=C2)S(=O)(=O)N3CCC[C@H]3C(=O)N[C@@H](CC(=O)N)C#N	IC50 ~ 50000 nM	Poor binder
T68290	Cathepsin S	BY0MR7	Morpholine-4-carboxylic acid (3-methyl-1-prop-2-ynylcarbamoyl-butyl)-amide	Investigative	10858935	C14H23N3O3	281.35	CC(C)C[C@@H](C(=O)NCC#C)NC(=O)N1CCOCC1	IC50 = 97000 nM	Poor binder
T68290	Cathepsin S	BZ24RN	(1R,21S,24S)-21-Tert-butyl-N-[(1R,2S)-1-(cyclopropylsulfonylcarbamoyl)-2-ethenylcyclopropyl]-16,16-dimethyl-3,19,22-trioxo-2,18-dioxa-4,20,23-triazatetracyclo[21.2.1.14,7.06,11]heptacosa-6(11),7,9-triene-24-carboxamide	Investigative	46228924	C38H53N5O9S	755.9	CC1(CCCCC2=C3CN(CC3=CC=C2)C(=O)O[C@@H]4C[C@H](N(C4)C(=O)[C@@H](NC(=O)OC1)C(C)(C)C)C(=O)N[C@@]5(C[C@H]5C=C)C(=O)NS(=O)(=O)C6CC6)C	IC50 = 78000 nM	Poor binder
T68290	Cathepsin S	D0A5WN	PTosyl-Glu(OtBu)-Ala-LeuVSMe	Investigative	11621347	C27H43N3O8S2	601.8	CC1=CC=C(C=C1)S(=O)(=O)N[C@@H](CCC(=O)OC(C)(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)/C=C/S(=O)(=O)C	IC50 = 67000 nM	Poor binder