TTD_Target_ID	Target_Name	TTD_Drug_ID	Drug_Name	Drug_Highest_Status	Drug_PubchemID	Molecular_Formula	Molecular_Weight	Canonical_SMILES	Activity	Binder_Type
T68698	Adenosylhomocysteinase	B0GZ7H	2-[5-Chloro-2-(4-chlorophenoxy)-N-[2-[2,3-dihydro-1H-inden-2-yl(methyl)amino]-2-oxoethyl]anilino]-N-methyl-N-(2-pyrrolidin-1-ylethyl)acetamide	Investigative	122183897	C33H38Cl2N4O3	609.6	CN(CCN1CCCC1)C(=O)CN(CC(=O)N(C)C2CC3=CC=CC=C3C2)C4=C(C=CC(=C4)Cl)OC5=CC=C(C=C5)Cl	IC50 ~ 100000 nM	Poor binder
T68698	Adenosylhomocysteinase	B0HY8S	(1S,2R,5S)-5-(6-Amino-purin-9-yl)-4-fluoro-3-mercaptomethyl-cyclopent-3-ene-1,2-diol	Investigative	44396175	C11H12FN5O2S	297.31	C1=NC(=C2C(=N1)N(C=N2)[C@H]3[C@@H]([C@@H](C(=C3F)CS)O)O)N	IC50 = 97270 nM	Poor binder
T68698	Adenosylhomocysteinase	B14WNX	(1S,2R,5S)-5-(6-Amino-purin-9-yl)-3-azidomethyl-4-fluoro-cyclopent-3-ene-1,2-diol	Investigative	44396071	C11H11FN8O2	306.26	C1=NC(=C2C(=N1)N(C=N2)[C@H]3[C@@H]([C@@H](C(=C3F)CN=[N+]=[N-])O)O)N	IC50 ~ 100000 nM	Poor binder
T68698	Adenosylhomocysteinase	B16YKM	7-[(1R,4R,5S)-4,5-Dihydroxy-3-(hydroxymethyl)cyclopent-2-en-1-yl]-3H-pyrrolo[2,3-d]pyrimidin-4-one	Investigative	137090971	C12H13N3O4	263.25	C1=CN(C2=C1C(=O)NC=N2)[C@@H]3C=C([C@H]([C@H]3O)O)CO	IC50 ~ 100000 nM	Poor binder
T68698	Adenosylhomocysteinase	B2Q8OD	7-[(1S,4R,5S)-2-Fluoro-4,5-dihydroxy-3-(hydroxymethyl)cyclopent-2-en-1-yl]-3H-pyrrolo[2,3-d]pyrimidin-4-one	Investigative	137090972	C12H12FN3O4	281.24	C1=CN(C2=C1C(=O)NC=N2)[C@H]3[C@@H]([C@@H](C(=C3F)CO)O)O	IC50 ~ 100000 nM	Poor binder
T68698	Adenosylhomocysteinase	B31ELH	2-[5-Chloro-2-(4-chlorophenoxy)-N-(2-oxo-3-piperidin-4-ylbutyl)anilino]-N-(2-pyrrolidin-1-ylethyl)acetamide	Investigative	122183896	C29H38Cl2N4O3	561.5	CC(C1CCNCC1)C(=O)CN(CC(=O)NCCN2CCCC2)C3=C(C=CC(=C3)Cl)OC4=CC=C(C=C4)Cl	IC50 ~ 100000 nM	Poor binder
T68698	Adenosylhomocysteinase	B32ZCF	(1S,2R,5R)-5-(4-Aminopyrrolo[2,3-d]pyrimidin-7-yl)-3-(hydroxymethyl)cyclopent-3-ene-1,2-diol	Investigative	11615884	C12H14N4O3	262.26	C1=CN(C2=NC=NC(=C21)N)[C@@H]3C=C([C@H]([C@H]3O)O)CO	IC50 ~ 100000 nM	Poor binder
T68698	Adenosylhomocysteinase	B37XCJ	(1S,2R,5R)-5-(4-Aminopyrrolo[2,3-d]pyrimidin-7-yl)-3-(2-hydroxyethyl)cyclopent-3-ene-1,2-diol	Investigative	122178506	C13H16N4O3	276.29	C1=CN(C2=NC=NC(=C21)N)[C@@H]3C=C([C@H]([C@H]3O)O)CCO	IC50 ~ 100000 nM	Poor binder
T68698	Adenosylhomocysteinase	B4OB2U	(3R,4S,5S)-2-(6-Aminopurin-9-yl)-5-[(2S)-thiiran-2-yl]oxolane-3,4-diol	Investigative	46877212	C11H13N5O3S	295.32	C1[C@@H](S1)[C@@H]2[C@H]([C@H](C(O2)N3C=NC4=C(N=CN=C43)N)O)O	Ki = 50000 nM	Poor binder
T68698	Adenosylhomocysteinase	B4ZRX6	2-[5-Chloro-2-(4-chlorophenoxy)-N-[2-(1,3-dihydroisoindol-2-yl)-2-oxoethyl]anilino]-N-(2-pyrrolidin-1-ylethyl)acetamide	Investigative	118710211	C30H32Cl2N4O3	567.5	C1CCN(C1)CCNC(=O)CN(CC(=O)N2CC3=CC=CC=C3C2)C4=C(C=CC(=C4)Cl)OC5=CC=C(C=C5)Cl	IC50 ~ 100000 nM	Poor binder
T68698	Adenosylhomocysteinase	B52XON	[(2S,3S,4R)-5-(6-Aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl thiocyanate	Investigative	46874106	C11H12N6O3S	308.32	C1=NC(=C2C(=N1)N(C=N2)C3[C@@H]([C@@H]([C@H](O3)CSC#N)O)O)N	Ki = 67000 nM	Poor binder
T68698	Adenosylhomocysteinase	B5CW0N	(1s,2r,5s)-5-(6-Amino-9h-purin-9-yl)-4-fluoro-3-(fluoromethyl)cyclopent-3-ene-1,2-diol	Investigative	44396095	C11H11F2N5O2	283.23	C1=NC(=C2C(=N1)N(C=N2)[C@H]3[C@@H]([C@@H](C(=C3F)CF)O)O)N	IC50 ~ 100000 nM	Poor binder
T68698	Adenosylhomocysteinase	B5G9OF	(1R,2S,3R,5S)-3-(6-Aminopurin-9-yl)-5-azidocyclopentane-1,2-diol	Investigative	490432	C10H12N8O2	276.26	C1[C@@H]([C@H]([C@H]([C@@H]1N2C=NC3=C(N=CN=C32)N)O)O)N=[N+]=[N-]	IC50 = 123000 nM	Poor binder
T68698	Adenosylhomocysteinase	B6JOQ3	5'-Amino-5'-deoxyadenosine	Investigative	9816781	C10H14N6O3	266.26	C1=NC(=C2C(=N1)N(C=N2)[C@H]3[C@@H]([C@@H]([C@H](O3)CN)O)O)N	IC50 = 75020 nM	Poor binder
T68698	Adenosylhomocysteinase	B7DSN6	1-beta-d-Arabinofuranosyl-1H-imidazo[4,5-c]pyridin-4-amine	Investigative	12769724	C11H14N4O4	266.25	C1=CN=C(C2=C1N(C=N2)[C@H]3[C@H]([C@@H]([C@H](O3)CO)O)O)N	IC50 = 100000 nM	Poor binder
T68698	Adenosylhomocysteinase	B7TOZ9	2-[5-Chloro-2-(4-chlorophenoxy)-N-[2-[methyl(piperidin-4-yl)amino]-2-oxoethyl]anilino]-N-(2-pyrrolidin-1-ylethyl)acetamide	Investigative	118710217	C28H37Cl2N5O3	562.5	CN(C1CCNCC1)C(=O)CN(CC(=O)NCCN2CCCC2)C3=C(C=CC(=C3)Cl)OC4=CC=C(C=C4)Cl	IC50 ~ 100000 nM	Poor binder
T68698	Adenosylhomocysteinase	B8N0BV	5-(6-Aminopurin-9-yl)-4-bromo-3-hydroxymethyl-cyclopent-3-ene-1,2-diol	Investigative	51003093	C11H12BrN5O3	342.15	C1=NC(=C2C(=N1)N(C=N2)[C@H]3[C@@H]([C@@H](C(=C3Br)CO)O)O)N	IC50 = 60170 nM	Poor binder
T68698	Adenosylhomocysteinase	B8X0WQ	2-Fluoronoraristeromycin	Investigative	9993207	C10H12FN5O3	269.23	C1[C@H]([C@@H]([C@@H]([C@H]1O)O)O)N2C=NC3=C(N=C(N=C32)F)N	IC50 = 63000 nM	Poor binder
T68698	Adenosylhomocysteinase	BC02JQ	(1S,2R,3S,5R)-3-Amino-5-(6-aminopurin-9-yl)cyclopentane-1,2-diol	Investigative	490433	C10H14N6O2	250.26	C1[C@@H]([C@H]([C@H]([C@@H]1N2C=NC3=C(N=CN=C32)N)O)O)N	IC50 = 76000 nM	Poor binder
T68698	Adenosylhomocysteinase	BC1AB5	(1S,2R,5R)-3-(Hydroxymethyl)-5-[4-(methylamino)pyrrolo[2,3-d]pyrimidin-7-yl]cyclopent-3-ene-1,2-diol	Investigative	122178501	C13H16N4O3	276.29	CNC1=C2C=CN(C2=NC=N1)[C@@H]3C=C([C@H]([C@H]3O)O)CO	IC50 ~ 100000 nM	Poor binder
T68698	Adenosylhomocysteinase	BCHG59	(3R,4S,5R)-2-(6-Aminopurin-9-yl)-5-[(E)-4-iodobut-1-en-3-ynyl]oxolane-3,4-diol	Investigative	46877337	C13H12IN5O3	413.17	C1=NC(=C2C(=N1)N(C=N2)C3[C@@H]([C@@H]([C@H](O3)/C=C/C#CI)O)O)N	Ki = 118500 nM	Poor binder
T68698	Adenosylhomocysteinase	BJ48HX	3-(6-Amino-purin-9-yl)-5-phenyl-cyclopentane-1,2-diol	Investigative	501520	C16H17N5O2	311.34	C1[C@@H]([C@H]([C@H]([C@@H]1N2C=NC3=C(N=CN=C32)N)O)O)C4=CC=CC=C4	Ki = 67600 nM	Poor binder
T68698	Adenosylhomocysteinase	BK52LI	3-(4-Amino-pyrrolo[2,3-d]pyrimidin-7-yl)-cyclopentane-1,2-diol	Investigative	44373339	C11H14N4O2	234.25	C1CC(C(C1N2C=CC3=C(N=CN=C32)N)O)O	IC50 ~ 100000 nM	Poor binder
T68698	Adenosylhomocysteinase	BLC84M	(1S,2R,5S)-5-(4-Aminopyrrolo[2,3-d]pyrimidin-7-yl)-4-fluoro-3-(hydroxymethyl)cyclopent-3-ene-1,2-diol	Investigative	122178503	C12H13FN4O3	280.25	C1=CN(C2=NC=NC(=C21)N)[C@H]3[C@@H]([C@@H](C(=C3F)CO)O)O	IC50 ~ 100000 nM	Poor binder
T68698	Adenosylhomocysteinase	BM12XI	2-Fluoroethyl 2-[(2R,3S,4R)-5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]acetate	Investigative	46877209	C13H16FN5O5	341.3	C1=NC(=C2C(=N1)N(C=N2)C3[C@@H]([C@@H]([C@H](O3)CC(=O)OCCF)O)O)N	Ki = 75000 nM	Poor binder
T68698	Adenosylhomocysteinase	BM8XZ5	(1S,2R,5S)-4-Fluoro-3-(hydroxymethyl)-5-[4-(methylamino)pyrrolo[2,3-d]pyrimidin-7-yl]cyclopent-3-ene-1,2-diol	Investigative	122178504	C13H15FN4O3	294.28	CNC1=C2C=CN(C2=NC=N1)[C@H]3[C@@H]([C@@H](C(=C3F)CO)O)O	IC50 ~ 100000 nM	Poor binder
T68698	Adenosylhomocysteinase	BP3Q2J	(3R,4S,5S)-2-(6-Aminopurin-9-yl)-5-[(2R)-thiiran-2-yl]oxolane-3,4-diol	Investigative	46877302	C11H13N5O3S	295.32	C1[C@H](S1)[C@@H]2[C@H]([C@H](C(O2)N3C=NC4=C(N=CN=C43)N)O)O	Ki = 105000 nM	Poor binder
T68698	Adenosylhomocysteinase	BPZ07C	3alpha-(6-Amino-9H-purine-9-yl)-5beta-azidocyclopentane-1beta,2beta-diol	Investigative	44450578	C10H12N8O2	276.26	C1[C@H]([C@H]([C@H]([C@@H]1N2C=NC3=C(N=CN=C32)N)O)O)N=[N+]=[N-]	IC50 = 163000 nM	Poor binder
T68698	Adenosylhomocysteinase	BXE27B	(1R,2S,3R,5R)-3-(2,6-Diaminopurin-9-yl)-5-(hydroxymethyl)cyclopentane-1,2-diol	Investigative	6474190	C11H16N6O3	280.28	C1[C@@H]([C@H]([C@H]([C@@H]1N2C=NC3=C(N=C(N=C32)N)N)O)O)CO	IC50 = 90700 nM	Poor binder
T68698	Adenosylhomocysteinase	BZ6IS4	(3S,4R,5R)-2-(6-Aminopurin-9-yl)-5-[[[(2S,3S,4R)-5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyldisulfanyl]methyl]oxolane-3,4-diol	Investigative	46877338	C20H24N10O6S2	564.6	C1=NC(=C2C(=N1)N(C=N2)C3[C@@H]([C@@H]([C@H](O3)CSSC[C@H]4[C@@H]([C@@H](C(O4)N5C=NC6=C(N=CN=C65)N)O)O)O)O)N	Ki = 96000 nM	Poor binder