TTD_Target_ID	Target_Name	TTD_Drug_ID	Drug_Name	Drug_Highest_Status	Drug_PubchemID	Molecular_Formula	Molecular_Weight	Canonical_SMILES	Activity	Binder_Type
T69563	Oxalosuccinate decarboxylase	D07GRH	Ciclopirox	Approved	2749	C12H17NO2	207.27	CC1=CC(=O)N(C(=C1)C2CCCCC2)O	Ki ~ 50000 nM	Poor binder
T69563	Oxalosuccinate decarboxylase	B10YSM	(5E)-3-Methyl-5-(pyridin-4-ylmethylidene)-2-sulfanylideneimidazolidin-4-one	Investigative	19287893	C10H9N3OS	219.27	CN1C(=O)/C(=C\\C2=CC=NC=C2)/NC1=S	Ki ~ 50000 nM	Poor binder
T69563	Oxalosuccinate decarboxylase	B15XTO	NS(=O)(=O)c1ccc(Cc2c(nn(-c3nc(cs3)C(O)=O)c2-c2cccnc2)-c2ccccc2)cc1	Investigative	121461818	C25H19N5O4S2	517.6	C1=CC=C(C=C1)C2=NN(C(=C2CC3=CC=C(C=C3)S(=O)(=O)N)C4=CN=CC=C4)C5=NC(=CS5)C(=O)O	IC50 ~ 57000 nM	Poor binder
T69563	Oxalosuccinate decarboxylase	B17LUB	4-[(1R)-1-Hydroxyethyl]-3-[2-[1-(5-pyridin-3-yl-1,3,4-oxadiazol-2-yl)ethylamino]pyrimidin-4-yl]-1,3-oxazolidin-2-one	Investigative	131635557	C18H19N7O4	397.4	C[C@H](C1COC(=O)N1C2=NC(=NC=C2)NC(C)C3=NN=C(O3)C4=CN=CC=C4)O	IC50 ~ 50000 nM	Poor binder
T69563	Oxalosuccinate decarboxylase	B1T7GN	Chembl4280797	Investigative	145980147	C13H12O3	216.23	CC1=CC(=O)C(=C(O1)CC2=CC=CC=C2)O	IC50 ~ 50000 nM	Poor binder
T69563	Oxalosuccinate decarboxylase	B20TEQ	6-Phenyl-4-methyl-1-hydroxypyridin-2(1H)-one	Investigative	13590965	C12H11NO2	201.22	CC1=CC(=O)N(C(=C1)C2=CC=CC=C2)O	Ki ~ 50000 nM	Poor binder
T69563	Oxalosuccinate decarboxylase	B2DMS8	2-[3-Phenyl-4-[(4-sulfamoylphenyl)methyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid	Investigative	121457701	C20H16N4O4S2	440.5	C1=CC=C(C=C1)C2=NN(C=C2CC3=CC=C(C=C3)S(=O)(=O)N)C4=NC(=CS4)C(=O)O	IC50 ~ 57000 nM	Poor binder
T69563	Oxalosuccinate decarboxylase	B2OD7R	(S)-4-Isopropyl-3-(2-((S)-1-(piperidin-4-yl)ethylamino)pyrimidin-4-yl)oxazolidin-2-one	Investigative	86730270	C17H27N5O2	333.4	C[C@@H](C1CCNCC1)NC2=NC=CC(=N2)N3[C@H](COC3=O)C(C)C	IC50 ~ 50000 nM	Poor binder
T69563	Oxalosuccinate decarboxylase	B2TQS7	N-Cyclohexyl-2-(N-(3-fluorophenyl)-2-(2-methyl-1H-imidazol-1-yl)acetamido)-2-o-tolylacetamide	Investigative	56645356	C27H31FN4O2	462.6	CC1=CC=CC=C1C(C(=O)NC2CCCCC2)N(C3=CC(=CC=C3)F)C(=O)CN4C=CN=C4C	IC50 ~ 100000 nM	Poor binder
T69563	Oxalosuccinate decarboxylase	B3DPN5	3-[2-(1-Adamantylmethylamino)pyrimidin-4-yl]-1,3-oxazolidin-2-one	Investigative	89490062	C18H24N4O2	328.4	C1COC(=O)N1C2=NC(=NC=C2)NCC34CC5CC(C3)CC(C5)C4	IC50 ~ 50000 nM	Poor binder
T69563	Oxalosuccinate decarboxylase	B3JA4D	(5E)-5-[(2-Bromopyridin-4-yl)methylidene]-2-sulfanylideneimidazolidin-4-one	Investigative	122186468	C9H6BrN3OS	284.13	C1=CN=C(C=C1/C=C/2\\C(=O)NC(=S)N2)Br	Ki ~ 50000 nM	Poor binder
T69563	Oxalosuccinate decarboxylase	B3YEW2	Chembl4293250	Investigative	145987904	C20H18O4	322.4	CC1=CC(=O)C(=C(O1)CC2=CC=C(C=C2)OCC3=CC=CC=C3)O	IC50 ~ 50000 nM	Poor binder
T69563	Oxalosuccinate decarboxylase	B4F7LT	1-Hydroxy-6-(1-phenylethyl)pyridin-2-one	Investigative	118717066	C13H13NO2	215.25	CC(C1=CC=CC=C1)C2=CC=CC(=O)N2O	Ki ~ 50000 nM	Poor binder
T69563	Oxalosuccinate decarboxylase	B4S6DU	N-Cyclohexyl-2-(3-fluoro-N-(2-indol-1-ylacetyl)anilino)-2-(2-methylphenyl)acetamide	Investigative	68056593	C31H32FN3O2	497.6	CC1=CC=CC=C1C(C(=O)NC2CCCCC2)N(C3=CC(=CC=C3)F)C(=O)CN4C=CC5=CC=CC=C54	IC50 ~ 100000 nM	Poor binder
T69563	Oxalosuccinate decarboxylase	B4V9YH	(4S)-3-[5-Chloro-2-[[(1S)-1-naphthalen-2-ylethyl]amino]pyrimidin-4-yl]-4-propan-2-yl-1,3-oxazolidin-2-one	Investigative	89490069	C22H23ClN4O2	410.9	C[C@@H](C1=CC2=CC=CC=C2C=C1)NC3=NC=C(C(=N3)N4[C@H](COC4=O)C(C)C)Cl	IC50 ~ 50000 nM	Poor binder
T69563	Oxalosuccinate decarboxylase	B4Y9NM	2-[(4E)-4-[(6-Methoxypyridin-3-yl)methylidene]-5-oxo-2-sulfanylideneimidazolidin-1-yl]acetic acid	Investigative	122186456	C12H11N3O4S	293.3	COC1=NC=C(C=C1)/C=C/2\\C(=O)N(C(=S)N2)CC(=O)O	Ki ~ 50000 nM	Poor binder
T69563	Oxalosuccinate decarboxylase	B57NMR	5-[(E)-(2-Amino-5-oxo-1H-imidazol-4-ylidene)methyl]-1H-pyridin-2-one	Investigative	136110950	C9H8N4O2	204.19	C1=CC(=O)NC=C1/C=C/2\\C(=O)NC(=N2)N	Ki ~ 50000 nM	Poor binder
T69563	Oxalosuccinate decarboxylase	B5F8XD	(S)-3-{2-[(S)-1-(1-Cyclobutyl-piperidin-4-yl)-ethylamino]-pyrimidin-4-yl}-4-isopropyl-oxazolidin-2-one	Investigative	86730273	C21H33N5O2	387.5	C[C@@H](C1CCN(CC1)C2CCC2)NC3=NC=CC(=N3)N4[C@H](COC4=O)C(C)C	IC50 ~ 50000 nM	Poor binder
T69563	Oxalosuccinate decarboxylase	B5I6XQ	NS(=O)(=O)c1ccc(Nc2cn(nc2-c2cccc(c2)-c2ccccc2)-c2nc(cs2)C(O)=O)cc1	Investigative	121461757	C25H19N5O4S2	517.6	C1=CC=C(C=C1)C2=CC(=CC=C2)C3=NN(C=C3NC4=CC=C(C=C4)S(=O)(=O)N)C5=NC(=CS5)C(=O)O	IC50 ~ 57000 nM	Poor binder
T69563	Oxalosuccinate decarboxylase	B5M3AL	2-(3-Fluoro-N-(2-thiophen-2-ylacetyl)anilino)-2-(2-methylphenyl)-N-piperidin-4-ylacetamide	Investigative	71461016	C26H28FN3O2S	465.6	CC1=CC=CC=C1C(C(=O)NC2CCNCC2)N(C3=CC(=CC=C3)F)C(=O)CC4=CC=CS4	IC50 = 53100 nM	Poor binder
T69563	Oxalosuccinate decarboxylase	B5NL0A	(4S)-3-[2-[1-(Furan-2-yl)ethylamino]pyrimidin-4-yl]-4-propan-2-yl-1,3-oxazolidin-2-one	Investigative	89489925	C16H20N4O3	316.35	CC(C)[C@H]1COC(=O)N1C2=NC(=NC=C2)NC(C)C3=CC=CO3	IC50 ~ 50000 nM	Poor binder
T69563	Oxalosuccinate decarboxylase	B5QVX7	3-[2-[1-[5-(2-Fluorophenyl)-1,3,4-oxadiazol-2-yl]ethylamino]pyrimidin-4-yl]-4-[(1R)-1-hydroxyethyl]-1,3-oxazolidin-2-one	Investigative	131635553	C19H19FN6O4	414.4	C[C@H](C1COC(=O)N1C2=NC(=NC=C2)NC(C)C3=NN=C(O3)C4=CC=CC=C4F)O	IC50 ~ 50000 nM	Poor binder
T69563	Oxalosuccinate decarboxylase	B5TX9F	5-[(E)-(2-Methylsulfanyl-5-oxo-1H-imidazol-4-ylidene)methyl]-1H-pyridin-2-one	Investigative	136110951	C10H9N3O2S	235.26	CSC1=N/C(=C/C2=CNC(=O)C=C2)/C(=O)N1	Ki ~ 50000 nM	Poor binder
T69563	Oxalosuccinate decarboxylase	B62CKN	4,5-Dihydroxy-2-benzylpyrimidine	Investigative	44541208	C11H10N2O2	202.21	C1=CC=C(C=C1)CC2=NC=C(C(=O)N2)O	Ki ~ 50000 nM	Poor binder
T69563	Oxalosuccinate decarboxylase	B6I1WZ	Nc1c(Cc2ccc(cc2)S(N)(=O)=O)c(nn1-c1nc(cs1)C(O)=O)-c1cccc(c1)-c1ccccc1	Investigative	121461721	C26H21N5O4S2	531.6	C1=CC=C(C=C1)C2=CC(=CC=C2)C3=NN(C(=C3CC4=CC=C(C=C4)S(=O)(=O)N)N)C5=NC(=CS5)C(=O)O	IC50 ~ 57000 nM	Poor binder
T69563	Oxalosuccinate decarboxylase	B6LF7A	2-[5-[3-(2-Fluorophenyl)phenyl]-3-oxo-4-[(4-sulfamoylphenyl)methyl]-1H-pyrazol-2-yl]-1,3-thiazole-4-carboxylic acid	Investigative	121461708	C26H19FN4O5S2	550.6	C1=CC=C(C(=C1)C2=CC(=CC=C2)C3=C(C(=O)N(N3)C4=NC(=CS4)C(=O)O)CC5=CC=C(C=C5)S(=O)(=O)N)F	IC50 ~ 57000 nM	Poor binder
T69563	Oxalosuccinate decarboxylase	B6Q4MU	2-Thioxo-5-(2-methoxypyridine-5-ylmethylene)thiazolidine-4-one	Investigative	122186471	C10H8N2O2S2	252.3	COC1=NC=C(C=C1)/C=C/2\\C(=O)NC(=S)S2	Ki ~ 50000 nM	Poor binder
T69563	Oxalosuccinate decarboxylase	B7CWJ2	(5E)-5-(3,4-Dimethoxybenzylidene)-2-mercapto-3-phenyl-3,5-dihydro-4H-imidazol-4-one	Investigative	5760176	C18H16N2O3S	340.4	COC1=C(C=C(C=C1)/C=C/2\\C(=O)N(C(=S)N2)C3=CC=CC=C3)OC	Ki ~ 50000 nM	Poor binder
T69563	Oxalosuccinate decarboxylase	B7X6IC	(4S)-4-Propan-2-yl-3-[2-[[(1R)-1-(3-propyl-1,2,4-oxadiazol-5-yl)ethyl]amino]pyrimidin-4-yl]-1,3-oxazolidin-2-one	Investigative	91824843	C17H24N6O3	360.4	CCCC1=NOC(=N1)[C@@H](C)NC2=NC=CC(=N2)N3[C@H](COC3=O)C(C)C	IC50 ~ 50000 nM	Poor binder
T69563	Oxalosuccinate decarboxylase	B80SGC	(4S)-3-[2-[1-(4-Ethyl-1,2,4-triazol-3-yl)ethylamino]pyrimidin-4-yl]-4-propan-2-yl-1,3-oxazolidin-2-one	Investigative	89489835	C16H23N7O2	345.4	CCN1C=NN=C1C(C)NC2=NC=CC(=N2)N3[C@H](COC3=O)C(C)C	IC50 ~ 50000 nM	Poor binder
T69563	Oxalosuccinate decarboxylase	B86UQD	6-Benzyl-1-hydroxy-4-propan-2-ylpyridin-2-one	Investigative	71816678	C15H17NO2	243.3	CC(C)C1=CC(=O)N(C(=C1)CC2=CC=CC=C2)O	Ki ~ 50000 nM	Poor binder
T69563	Oxalosuccinate decarboxylase	B8D2CM	2-[(4E)-5-Oxo-4-[(6-oxo-1H-pyridin-3-yl)methylidene]-2-sulfanylideneimidazolidin-1-yl]acetic acid	Investigative	122186457	C11H9N3O4S	279.27	C1=CC(=O)NC=C1/C=C/2\\C(=O)N(C(=S)N2)CC(=O)O	Ki ~ 50000 nM	Poor binder
T69563	Oxalosuccinate decarboxylase	B8GB3I	1-Hydroxy-5-phenylpyridin-2-one	Investigative	44543378	C11H9NO2	187.19	C1=CC=C(C=C1)C2=CN(C(=O)C=C2)O	Ki = 50000 nM	Poor binder
T69563	Oxalosuccinate decarboxylase	B8MIO9	(5E)-3-Benzyl-5-(pyridin-3-ylmethylidene)-2-sulfanylideneimidazolidin-4-one	Investigative	122186447	C16H13N3OS	295.4	C1=CC=C(C=C1)CN2C(=O)/C(=C\\C3=CN=CC=C3)/NC2=S	Ki ~ 50000 nM	Poor binder
T69563	Oxalosuccinate decarboxylase	B98DQM	Metipirox	Investigative	3047730	C7H9NO2	139.15	CC1=CC(=O)N(C(=C1)C)O	Ki ~ 50000 nM	Poor binder
T69563	Oxalosuccinate decarboxylase	B9F5TY	(4S)-4-Propan-2-yl-3-[2-[[(1S)-1-(2H-tetrazol-5-yl)ethyl]amino]pyrimidin-4-yl]-1,3-oxazolidin-2-one	Investigative	89489939	C13H18N8O2	318.33	C[C@@H](C1=NNN=N1)NC2=NC=CC(=N2)N3[C@H](COC3=O)C(C)C	IC50 ~ 50000 nM	Poor binder
T69563	Oxalosuccinate decarboxylase	B9UG8X	1-Hydroxy-3-benzylimidazol-2-one	Investigative	44541206	C10H10N2O2	190.2	C1=CC=C(C=C1)CN2C=CN(C2=O)O	Ki ~ 50000 nM	Poor binder
T69563	Oxalosuccinate decarboxylase	B9UTQ5	(4S)-3-[2-[1-(1-Benzyltriazol-4-yl)ethylamino]pyrimidin-4-yl]-4-propan-2-yl-1,3-oxazolidin-2-one	Investigative	89489934	C21H25N7O2	407.5	CC(C)[C@H]1COC(=O)N1C2=NC(=NC=C2)NC(C)C3=CN(N=N3)CC4=CC=CC=C4	IC50 ~ 50000 nM	Poor binder
T69563	Oxalosuccinate decarboxylase	BBF7G0	(4S)-3-[2-[1-(1-Ethylpyrazol-3-yl)ethylamino]pyrimidin-4-yl]-4-propan-2-yl-1,3-oxazolidin-2-one	Investigative	89489821	C17H24N6O2	344.4	CCN1C=CC(=N1)C(C)NC2=NC=CC(=N2)N3[C@H](COC3=O)C(C)C	IC50 ~ 50000 nM	Poor binder
T69563	Oxalosuccinate decarboxylase	BBT5V8	(4R)-4-Benzyl-3-[2-(cyclopropylamino)pyrimidin-4-yl]-1,3-oxazolidin-2-one	Investigative	89490037	C17H18N4O2	310.35	C1CC1NC2=NC=CC(=N2)N3[C@@H](COC3=O)CC4=CC=CC=C4	IC50 ~ 50000 nM	Poor binder
T69563	Oxalosuccinate decarboxylase	BCG92I	2-[5-(3-Bromophenyl)-3-oxo-4-[(4-sulfamoylphenyl)methyl]-1H-pyrazol-2-yl]-1,3-thiazole-4-carboxylic acid	Investigative	121461774	C20H15BrN4O5S2	535.4	C1=CC(=CC(=C1)Br)C2=C(C(=O)N(N2)C3=NC(=CS3)C(=O)O)CC4=CC=C(C=C4)S(=O)(=O)N	IC50 ~ 57000 nM	Poor binder
T69563	Oxalosuccinate decarboxylase	BDSG85	Chembl4279183	Investigative	145981660	C22H22O7	398.4	CCCOC1=CC=C(C=C1)C(C2=C(C(=O)C=C(O2)C)O)C3=C(C(=O)C=C(O3)C)O	IC50 ~ 50000 nM	Poor binder
T69563	Oxalosuccinate decarboxylase	BE0T7Z	5-Benzyl-1-hydroxy-2H-pyridin-2-ol	Investigative	73354948	C12H13NO2	203.24	C1=CC=C(C=C1)CC2=CN(C(C=C2)O)O	Ki ~ 50000 nM	Poor binder
T69563	Oxalosuccinate decarboxylase	BE0W2O	3-[2-[1-(5-Benzyl-1,2,4-oxadiazol-3-yl)ethylamino]-5-fluoropyrimidin-4-yl]-4-[(1R)-1-hydroxyethyl]-1,3-oxazolidin-2-one	Investigative	131635559	C20H21FN6O4	428.4	C[C@H](C1COC(=O)N1C2=NC(=NC=C2F)NC(C)C3=NOC(=N3)CC4=CC=CC=C4)O	IC50 ~ 50000 nM	Poor binder
T69563	Oxalosuccinate decarboxylase	BE9U0F	(4S)-3-[2-[1-(3-Methyl-1,2,4-oxadiazol-5-yl)ethylamino]pyrimidin-4-yl]-4-propan-2-yl-1,3-oxazolidin-2-one	Investigative	89489837	C15H20N6O3	332.36	CC1=NOC(=N1)C(C)NC2=NC=CC(=N2)N3[C@H](COC3=O)C(C)C	IC50 ~ 50000 nM	Poor binder
T69563	Oxalosuccinate decarboxylase	BEQ79P	4-[(1R)-1-Hydroxyethyl]-3-[2-[1-[3-(2-phenoxyethyl)-1,2,4-oxadiazol-5-yl]ethylamino]pyrimidin-4-yl]-1,3-oxazolidin-2-one	Investigative	131635550	C21H24N6O5	440.5	C[C@H](C1COC(=O)N1C2=NC(=NC=C2)NC(C)C3=NC(=NO3)CCOC4=CC=CC=C4)O	IC50 ~ 50000 nM	Poor binder
T69563	Oxalosuccinate decarboxylase	BERI78	3-[2-(Cyclopentylamino)pyrimidin-4-yl]-1,3-oxazolidin-2-one	Investigative	89489960	C12H16N4O2	248.28	C1CCC(C1)NC2=NC=CC(=N2)N3CCOC3=O	IC50 ~ 50000 nM	Poor binder
T69563	Oxalosuccinate decarboxylase	BF0XA1	Streptpyrone A	Investigative	21520193	C13H12O2	200.23	CC1=CC(=O)OC(=C1)CC2=CC=CC=C2	Ki ~ 50000 nM	Poor binder
T69563	Oxalosuccinate decarboxylase	BFE07W	6-Benzyl-1-Hydroxy-4-Methylpyridin-2(1h)-One	Investigative	13590964	C13H13NO2	215.25	CC1=CC(=O)N(C(=C1)CC2=CC=CC=C2)O	Ki ~ 50000 nM	Poor binder
T69563	Oxalosuccinate decarboxylase	BFG27Y	N-Cyclohexyl-2-[3-fluoro-N-(2-thiophen-2-ylethyl)anilino]-2-(2-methylphenyl)acetamide	Investigative	71453860	C27H31FN2OS	450.6	CC1=CC=CC=C1C(C(=O)NC2CCCCC2)N(CCC3=CC=CS3)C4=CC(=CC=C4)F	IC50 ~ 100000 nM	Poor binder
T69563	Oxalosuccinate decarboxylase	BFL8J7	Chembl4282653	Investigative	145981803	C14H11F3O3	284.23	CC1=CC(=O)C(=C(O1)CC2=CC=C(C=C2)C(F)(F)F)O	IC50 ~ 50000 nM	Poor binder
T69563	Oxalosuccinate decarboxylase	BFO3N1	C1=CC(=O)N(O)C(C=2C=CC=CC=2)=C1	Investigative	117603922	C11H9NO2	187.19	C1=CC=C(C=C1)C2=CC=CC(=O)N2O	Ki ~ 50000 nM	Poor binder
T69563	Oxalosuccinate decarboxylase	BFS26B	Chembl4289867	Investigative	145987773	C22H20O7	396.4	CC1=CC(=O)C(=C(O1)C(C2=CC=C(C=C2)OCC=C)C3=C(C(=O)C=C(O3)C)O)O	IC50 ~ 50000 nM	Poor binder
T69563	Oxalosuccinate decarboxylase	BGAU96	N-Benzyl-1-hydroxy-6-oxopyridine-3-carboxamide	Investigative	118717064	C13H12N2O3	244.25	C1=CC=C(C=C1)CNC(=O)C2=CN(C(=O)C=C2)O	Ki ~ 50000 nM	Poor binder
T69563	Oxalosuccinate decarboxylase	BH56RL	NS(=O)(=O)c1ccc(Cc2cn(nc2-c2ccc(F)c(F)c2)-c2nc(cs2)C(O)=O)cc1	Investigative	121461723	C20H14F2N4O4S2	476.5	C1=CC(=CC=C1CC2=CN(N=C2C3=CC(=C(C=C3)F)F)C4=NC(=CS4)C(=O)O)S(=O)(=O)N	IC50 ~ 57000 nM	Poor binder
T69563	Oxalosuccinate decarboxylase	BI9MD2	(R)-3-((2-Chlorophenyl)thio)-4-hydroxy-6-(4-morpholinophenyl)-6-(thiophen-3-yl)-5,6-dihydropyridin-2(1H)-one	Investigative	121225870	C25H23ClN2O3S2	499	C1COCCN1C2=CC=C(C=C2)[C@]3(CC(=C(C(=O)N3)SC4=CC=CC=C4Cl)O)C5=CSC=C5	IC50 ~ 57000 nM	Poor binder
T69563	Oxalosuccinate decarboxylase	BIG25F	(5E)-5-[(6-Oxo-1H-pyridin-3-yl)methylidene]imidazolidine-2,4-dione	Investigative	122186474	C9H7N3O3	205.17	C1=CC(=O)NC=C1/C=C/2\\C(=O)NC(=O)N2	Ki ~ 50000 nM	Poor binder
T69563	Oxalosuccinate decarboxylase	BJ4QE5	1-Hydroxy-5-(3-phenylpropyl)pyridin-2-one	Investigative	118717061	C14H15NO2	229.27	C1=CC=C(C=C1)CCCC2=CN(C(=O)C=C2)O	Ki ~ 50000 nM	Poor binder
T69563	Oxalosuccinate decarboxylase	BJ69IG	2-{3-(3,4-Difluorophenyl)-5-hydroxy-4-[(4-sulfamoylphenyl)methyl]-1H-pyrazol-1-yl}-1,3-thiazole-4-carboxylic acid	Investigative	121457603	C20H14F2N4O5S2	492.5	C1=CC(=CC=C1CC2=C(NN(C2=O)C3=NC(=CS3)C(=O)O)C4=CC(=C(C=C4)F)F)S(=O)(=O)N	IC50 ~ 57000 nM	Poor binder
T69563	Oxalosuccinate decarboxylase	BJC38B	Chembl4291032	Investigative	145988250	C13H11ClO3	250.68	CC1=CC(=O)C(=C(O1)CC2=CC=C(C=C2)Cl)O	IC50 ~ 50000 nM	Poor binder
T69563	Oxalosuccinate decarboxylase	BJE9R0	1,4-Dihydroxy-6-benzyl-2(1H)-pyridone	Investigative	101884792	C12H11NO3	217.22	C1=CC=C(C=C1)CC2=CC(=CC(=O)N2O)O	Ki ~ 50000 nM	Poor binder
T69563	Oxalosuccinate decarboxylase	BJY50O	1-Hydroxy-5-(2-phenylethyl)pyridin-2-one	Investigative	118717060	C13H13NO2	215.25	C1=CC=C(C=C1)CCC2=CN(C(=O)C=C2)O	Ki ~ 50000 nM	Poor binder
T69563	Oxalosuccinate decarboxylase	BK3WE1	(4R,5S)-4-Methyl-5-phenyl-3-[2-[[(1S)-1-phenylethyl]amino]pyrimidin-4-yl]-1,3-oxazolidin-2-one	Investigative	89489954	C22H22N4O2	374.4	C[C@@H]1[C@@H](OC(=O)N1C2=NC(=NC=C2)N[C@@H](C)C3=CC=CC=C3)C4=CC=CC=C4	IC50 ~ 50000 nM	Poor binder
T69563	Oxalosuccinate decarboxylase	BK5U1G	3-[2-(1-Phenylethylamino)pyrimidin-4-yl]-1,3-oxazolidin-2-one	Investigative	89490054	C15H16N4O2	284.31	CC(C1=CC=CC=C1)NC2=NC=CC(=N2)N3CCOC3=O	IC50 ~ 50000 nM	Poor binder
T69563	Oxalosuccinate decarboxylase	BKN37U	6-Benzyl-1-hydroxypyridin-2(1H)-one	Investigative	71816677	C12H11NO2	201.22	C1=CC=C(C=C1)CC2=CC=CC(=O)N2O	Ki ~ 50000 nM	Poor binder
T69563	Oxalosuccinate decarboxylase	BKP75E	Chembl4280398	Investigative	145981016	C13H11FO3	234.22	CC1=CC(=O)C(=C(O1)CC2=CC=C(C=C2)F)O	IC50 ~ 50000 nM	Poor binder
T69563	Oxalosuccinate decarboxylase	BL38PY	(S)-4-Isopropyl-3-{2-[(S)-1-(1-isopropyl-piperidin-4-yl)-ethylamino]-pyrimidin-4-yl}-oxazolidin-2-one	Investigative	86730274	C20H33N5O2	375.5	C[C@@H](C1CCN(CC1)C(C)C)NC2=NC=CC(=N2)N3[C@H](COC3=O)C(C)C	IC50 ~ 50000 nM	Poor binder
T69563	Oxalosuccinate decarboxylase	BL4CF2	(4R)-4-Benzyl-3-[2-(cyclopentylamino)pyrimidin-4-yl]-1,3-oxazolidin-2-one	Investigative	89489951	C19H22N4O2	338.4	C1CCC(C1)NC2=NC=CC(=N2)N3[C@@H](COC3=O)CC4=CC=CC=C4	IC50 ~ 50000 nM	Poor binder
T69563	Oxalosuccinate decarboxylase	BLT1J6	(4S)-3-[2-[[(2S)-1-Hydroxypropan-2-yl]amino]pyrimidin-4-yl]-5,5-dimethyl-4-phenyl-1,3-oxazolidin-2-one	Investigative	89489742	C18H22N4O3	342.4	C[C@@H](CO)NC1=NC=CC(=N1)N2[C@H](C(OC2=O)(C)C)C3=CC=CC=C3	IC50 ~ 50000 nM	Poor binder
T69563	Oxalosuccinate decarboxylase	BLT7J3	NS(=O)(=O)c1ccc(Cc2c(nn(-c3nc(cs3)C(O)=O)c2C2CC2)-c2ccccc2)cc1	Investigative	121461743	C23H20N4O4S2	480.6	C1CC1C2=C(C(=NN2C3=NC(=CS3)C(=O)O)C4=CC=CC=C4)CC5=CC=C(C=C5)S(=O)(=O)N	IC50 ~ 57000 nM	Poor binder
T69563	Oxalosuccinate decarboxylase	BMYX59	4-[(1R)-1-Hydroxyethyl]-3-[2-[1-[5-(3-methylphenyl)-1,3,4-oxadiazol-2-yl]ethylamino]pyrimidin-4-yl]-1,3-oxazolidin-2-one	Investigative	131635554	C20H22N6O4	410.4	CC1=CC(=CC=C1)C2=NN=C(O2)C(C)NC3=NC=CC(=N3)N4C(COC4=O)[C@@H](C)O	IC50 ~ 50000 nM	Poor binder
T69563	Oxalosuccinate decarboxylase	BN0TS7	NS(=O)(=O)c1ccc(Nc2cn(nc2-c2ccccc2)-c2nc(cs2)C(O)=O)cc1	Investigative	121457762	C19H15N5O4S2	441.5	C1=CC=C(C=C1)C2=NN(C=C2NC3=CC=C(C=C3)S(=O)(=O)N)C4=NC(=CS4)C(=O)O	IC50 ~ 57000 nM	Poor binder
T69563	Oxalosuccinate decarboxylase	BN26IE	3-[(1-Hydroxy-4-methyl-6-oxopyridin-2-yl)methyl]benzoic acid	Investigative	118717081	C14H13NO4	259.26	CC1=CC(=O)N(C(=C1)CC2=CC(=CC=C2)C(=O)O)O	Ki ~ 50000 nM	Poor binder
T69563	Oxalosuccinate decarboxylase	BN8I0C	(4S)-4-Propan-2-yl-3-[2-[1-[1-(pyridine-4-carbonyl)piperidin-4-yl]ethylamino]pyrimidin-4-yl]-1,3-oxazolidin-2-one	Investigative	89489793	C23H30N6O3	438.5	CC(C)[C@H]1COC(=O)N1C2=NC(=NC=C2)NC(C)C3CCN(CC3)C(=O)C4=CC=NC=C4	IC50 ~ 50000 nM	Poor binder
T69563	Oxalosuccinate decarboxylase	BNAD38	Chembl4294325	Investigative	145994156	C26H21NO9	491.4	CC1=CC(=O)C(=C(O1)C(C2=CC=C(C=C2)OCC3=CC=C(C=C3)[N+](=O)[O-])C4=C(C(=O)C=C(O4)C)O)O	IC50 ~ 50000 nM	Poor binder
T69563	Oxalosuccinate decarboxylase	BO9IL7	(4S)-4-Propan-2-yl-3-[2-[1-[1-(pyridine-3-carbonyl)piperidin-4-yl]ethylamino]pyrimidin-4-yl]-1,3-oxazolidin-2-one	Investigative	89490174	C23H30N6O3	438.5	CC(C)[C@H]1COC(=O)N1C2=NC(=NC=C2)NC(C)C3CCN(CC3)C(=O)C4=CN=CC=C4	IC50 ~ 50000 nM	Poor binder
T69563	Oxalosuccinate decarboxylase	BOP32J	3-[2-[1-(5-Benzyl-1,2,4-oxadiazol-3-yl)ethylamino]pyrimidin-4-yl]-4-[(1R)-1-hydroxyethyl]-1,3-oxazolidin-2-one	Investigative	131635558	C20H22N6O4	410.4	C[C@H](C1COC(=O)N1C2=NC(=NC=C2)NC(C)C3=NOC(=N3)CC4=CC=CC=C4)O	IC50 ~ 50000 nM	Poor binder
T69563	Oxalosuccinate decarboxylase	BQU9N0	(4S,5R)-4-Methyl-5-phenyl-3-[2-[[(1R)-1-phenylethyl]amino]pyrimidin-4-yl]-1,3-oxazolidin-2-one	Investigative	89489962	C22H22N4O2	374.4	C[C@H]1[C@H](OC(=O)N1C2=NC(=NC=C2)N[C@H](C)C3=CC=CC=C3)C4=CC=CC=C4	IC50 ~ 50000 nM	Poor binder
T69563	Oxalosuccinate decarboxylase	BRJE86	(4S)-4-Benzhydryl-3-[2-[[(1R)-1-phenylethyl]amino]pyrimidin-4-yl]-1,3-oxazolidin-2-one	Investigative	89489957	C28H26N4O2	450.5	C[C@H](C1=CC=CC=C1)NC2=NC=CC(=N2)N3[C@H](COC3=O)C(C4=CC=CC=C4)C5=CC=CC=C5	IC50 ~ 50000 nM	Poor binder
T69563	Oxalosuccinate decarboxylase	BS2A6P	(4R)-4-Benzyl-3-[2-(cycloheptylamino)pyrimidin-4-yl]-1,3-oxazolidin-2-one	Investigative	89490042	C21H26N4O2	366.5	C1CCCC(CC1)NC2=NC=CC(=N2)N3[C@@H](COC3=O)CC4=CC=CC=C4	IC50 ~ 50000 nM	Poor binder
T69563	Oxalosuccinate decarboxylase	BS2DQ5	{4-[4-({3-[(2-Methyl-1,3-benzothiazol-6-YL)amino]-3-oxopropyl}amino)-4-oxobutyl]benzyl}propanedioic acid	Investigative	56844254	C25H27N3O6S	497.6	CC1=NC2=C(S1)C=C(C=C2)NC(=O)CCNC(=O)CCCC3=CC=C(C=C3)CC(C(=O)O)C(=O)O	IC50 ~ 57000 nM	Poor binder
T69563	Oxalosuccinate decarboxylase	BS39UM	(5E)-3-Benzyl-5-[(6-methoxypyridin-3-yl)methylidene]-2-sulfanylideneimidazolidin-4-one	Investigative	122186448	C17H15N3O2S	325.4	COC1=NC=C(C=C1)/C=C/2\\C(=O)N(C(=S)N2)CC3=CC=CC=C3	Ki ~ 50000 nM	Poor binder
T69563	Oxalosuccinate decarboxylase	BS6AG5	(4S,5R)-4,5-Diphenyl-3-[2-[[(1R)-1-phenylethyl]amino]pyrimidin-4-yl]-1,3-oxazolidin-2-one	Investigative	89490151	C27H24N4O2	436.5	C[C@H](C1=CC=CC=C1)NC2=NC=CC(=N2)N3[C@H]([C@H](OC3=O)C4=CC=CC=C4)C5=CC=CC=C5	IC50 ~ 50000 nM	Poor binder
T69563	Oxalosuccinate decarboxylase	BS6D2Q	N-Cyclohexyl-2-(3-fluoro-N-[2-(2-methylbenzimidazol-1-yl)acetyl]anilino)-2-(2-methylphenyl)acetamide	Investigative	56645357	C31H33FN4O2	512.6	CC1=CC=CC=C1C(C(=O)NC2CCCCC2)N(C3=CC(=CC=C3)F)C(=O)CN4C(=NC5=CC=CC=C54)C	IC50 ~ 100000 nM	Poor binder
T69563	Oxalosuccinate decarboxylase	BS6M3T	(4S)-4-Isopropyl-3-(2-(2,2,2-trifluoro-1-phenylethylamino)pyrimidin-4-yl)oxazolidin-2-one	Investigative	86730216	C18H19F3N4O2	380.4	CC(C)[C@H]1COC(=O)N1C2=NC(=NC=C2)NC(C3=CC=CC=C3)C(F)(F)F	IC50 ~ 50000 nM	Poor binder
T69563	Oxalosuccinate decarboxylase	BSNW47	(5E)-5-[(3,4-Dimethoxyphenyl)methylidene]-3-[(4-methoxyphenyl)methyl]-2-sulfanylideneimidazolidin-4-one	Investigative	122186445	C20H20N2O4S	384.5	COC1=CC=C(C=C1)CN2C(=O)/C(=C\\C3=CC(=C(C=C3)OC)OC)/NC2=S	Ki ~ 50000 nM	Poor binder
T69563	Oxalosuccinate decarboxylase	BTCJ80	(4S)-4-Propan-2-yl-3-[2-[1-(3-pyridin-2-yl-1,2,4-oxadiazol-5-yl)ethylamino]pyrimidin-4-yl]-1,3-oxazolidin-2-one	Investigative	89489836	C19H21N7O3	395.4	CC(C)[C@H]1COC(=O)N1C2=NC(=NC=C2)NC(C)C3=NC(=NO3)C4=CC=CC=N4	IC50 ~ 50000 nM	Poor binder
T69563	Oxalosuccinate decarboxylase	BUI13D	(5E)-3-Benzyl-5-[(3,4-dimethoxyphenyl)methylidene]-2-sulfanylideneimidazolidin-4-one	Investigative	122186444	C19H18N2O3S	354.4	COC1=C(C=C(C=C1)/C=C/2\\C(=O)N(C(=S)N2)CC3=CC=CC=C3)OC	Ki ~ 50000 nM	Poor binder
T69563	Oxalosuccinate decarboxylase	BUK20V	(5E)-5-[(6-Methoxypyridin-3-yl)methylidene]imidazolidine-2,4-dione	Investigative	122186473	C10H9N3O3	219.2	COC1=NC=C(C=C1)/C=C/2\\C(=O)NC(=O)N2	Ki ~ 50000 nM	Poor binder
T69563	Oxalosuccinate decarboxylase	BUR08L	NS(=O)(=O)c1ccc(Cc2c(nn(-c3nc(cs3)C(O)=O)c2-c2ccncc2)-c2ccccc2)cc1	Investigative	121461684	C25H19N5O4S2	517.6	C1=CC=C(C=C1)C2=NN(C(=C2CC3=CC=C(C=C3)S(=O)(=O)N)C4=CC=NC=C4)C5=NC(=CS5)C(=O)O	IC50 ~ 57000 nM	Poor binder
T69563	Oxalosuccinate decarboxylase	BV0DX9	N,1-Dihydroxy-6-oxopyridine-3-carboxamide	Investigative	118717063	C6H6N2O4	170.12	C1=CC(=O)N(C=C1C(=O)NO)O	Ki ~ 50000 nM	Poor binder
T69563	Oxalosuccinate decarboxylase	BVLW58	N,1-Dihydroxy-6-oxopyridine-2-carboxamide	Investigative	118717069	C6H6N2O4	170.12	C1=CC(=O)N(C(=C1)C(=O)NO)O	Ki ~ 50000 nM	Poor binder
T69563	Oxalosuccinate decarboxylase	BVU2I9	Methyl 11-(1H-indol-3-yl)-3-methyl-1-oxo-2,3,4,5,10,11-hexahydro-1H-dibenzo[b,e][1,4]diazepine-2-carboxylate	Investigative	2942796	C24H23N3O3	401.5	CC1CC2=C(C(NC3=CC=CC=C3N2)C4=CNC5=CC=CC=C54)C(=O)C1C(=O)OC	IC50 = 50000 nM	Poor binder
T69563	Oxalosuccinate decarboxylase	BW82BV	(4S)-3-[2-[1-(2-Ethyl-1,2,4-triazol-3-yl)ethylamino]pyrimidin-4-yl]-4-propan-2-yl-1,3-oxazolidin-2-one	Investigative	89489831	C16H23N7O2	345.4	CCN1C(=NC=N1)C(C)NC2=NC=CC(=N2)N3[C@H](COC3=O)C(C)C	IC50 ~ 50000 nM	Poor binder
T69563	Oxalosuccinate decarboxylase	BW8L2J	3-[[3-[(Cyclopropylamino)sulfonyl]-7-(2,4-dimethoxy-5-pyrimidinyl)-4-quinolinyl]amino]-5-(3,5-difluo	Investigative	71533725	C31H25F2N5O7S	649.6	COC1=NC(=NC=C1C2=CC3=NC=C(C(=C3C=C2)NC4=CC(=CC(=C4)C(=O)O)OC5=CC(=CC(=C5)F)F)S(=O)(=O)NC6CC6)OC	IC50 ~ 57000 nM	Poor binder
T69563	Oxalosuccinate decarboxylase	BXM68C	(4S)-3-[2-[1-(5-Methyl-1,3,4-oxadiazol-2-yl)ethylamino]pyrimidin-4-yl]-4-propan-2-yl-1,3-oxazolidin-2-one	Investigative	89489833	C15H20N6O3	332.36	CC1=NN=C(O1)C(C)NC2=NC=CC(=N2)N3[C@H](COC3=O)C(C)C	IC50 ~ 50000 nM	Poor binder
T69563	Oxalosuccinate decarboxylase	BXQ8B5	3-[(E)-(1-Methyl-5-oxo-2-sulfanylideneimidazolidin-4-ylidene)methyl]-1H-pyridin-2-one	Investigative	122186463	C10H9N3O2S	235.26	CN1C(=O)/C(=C\\C2=CC=CNC2=O)/NC1=S	Ki ~ 50000 nM	Poor binder
T69563	Oxalosuccinate decarboxylase	BXRV81	6-Benzyl-4-methylpyran-2-thione	Investigative	118717094	C13H12OS	216.3	CC1=CC(=S)OC(=C1)CC2=CC=CC=C2	Ki ~ 50000 nM	Poor binder
T69563	Oxalosuccinate decarboxylase	BY1B3X	(4S)-3-[2-[1-(4-Methyl-1,2,4-triazol-3-yl)ethylamino]pyrimidin-4-yl]-4-propan-2-yl-1,3-oxazolidin-2-one	Investigative	90347623	C15H21N7O2	331.37	CC(C)[C@H]1COC(=O)N1C2=NC(=NC=C2)NC(C)C3=NN=CN3C	IC50 ~ 50000 nM	Poor binder
T69563	Oxalosuccinate decarboxylase	BY3ZN1	(4R)-4-(2-Methylpropyl)-3-[2-[[(1R)-1-phenylethyl]amino]pyrimidin-4-yl]-1,3-oxazolidin-2-one	Investigative	89490156	C19H24N4O2	340.4	C[C@H](C1=CC=CC=C1)NC2=NC=CC(=N2)N3[C@@H](COC3=O)CC(C)C	IC50 ~ 50000 nM	Poor binder
T69563	Oxalosuccinate decarboxylase	BY64DZ	N-(1-Hydroxy-6-oxopyridin-3-yl)-2-phenylacetamide	Investigative	118717065	C13H12N2O3	244.25	C1=CC=C(C=C1)CC(=O)NC2=CN(C(=O)C=C2)O	Ki ~ 50000 nM	Poor binder
T69563	Oxalosuccinate decarboxylase	BZ2A7S	Chembl4286444	Investigative	145992655	C27H24O6	444.5	CC1=CC(=O)C(=C(O1)C(C2=CC=C(C=C2)CCC3=CC=CC=C3)C4=C(C(=O)C=C(O4)C)O)O	IC50 ~ 50000 nM	Poor binder
T69563	Oxalosuccinate decarboxylase	BZ73IS	(4S)-3-[2-[1-(2-Ethylpyrazol-3-yl)ethylamino]pyrimidin-4-yl]-4-propan-2-yl-1,3-oxazolidin-2-one	Investigative	90347644	C17H24N6O2	344.4	CCN1C(=CC=N1)C(C)NC2=NC=CC(=N2)N3[C@H](COC3=O)C(C)C	IC50 ~ 50000 nM	Poor binder
T69563	Oxalosuccinate decarboxylase	BZF8H1	N-[2-(Cyclohexylamino)-1-(2-methylphenyl)ethyl]-N-(3-fluorophenyl)-2-thiophen-2-ylacetamide	Investigative	71462747	C27H31FN2OS	450.6	CC1=CC=CC=C1C(CNC2CCCCC2)N(C3=CC(=CC=C3)F)C(=O)CC4=CC=CS4	IC50 ~ 100000 nM	Poor binder
T69563	Oxalosuccinate decarboxylase	BZF9D0	(4S)-3-[2-[1-[4-(4-Methylpiperazin-1-yl)phenyl]ethylamino]pyrimidin-4-yl]-4-propan-2-yl-1,3-oxazolidin-2-one	Investigative	90347571	C23H32N6O2	424.5	CC(C)[C@H]1COC(=O)N1C2=NC(=NC=C2)NC(C)C3=CC=C(C=C3)N4CCN(CC4)C	IC50 ~ 50000 nM	Poor binder
T69563	Oxalosuccinate decarboxylase	BZK10F	(4R)-3-[2-[1-[4-(4-Bromophenyl)-1,3-thiazol-2-yl]ethylamino]-5-fluoropyrimidin-4-yl]-4-[(1R)-1-hydroxyethyl]-1,3-oxazolidin-2-one	Investigative	90451968	C20H19BrFN5O3S	508.4	C[C@H]([C@H]1COC(=O)N1C2=NC(=NC=C2F)NC(C)C3=NC(=CS3)C4=CC=C(C=C4)Br)O	IC50 ~ 50000 nM	Poor binder