TTD_Target_ID Target_Name TTD_Drug_ID Drug_Name Drug_Highest_Status Drug_PubchemID Molecular_Formula Molecular_Weight Canonical_SMILES Activity Binder_Type T69991 Wee1-like protein kinase B0T4NG 9-Hydroxy-4-phenyl-1H-furo[3,4-c]carbazole-1,3-(6H)-dione Investigative 11844481 C20H11NO4 329.3 C1=CC=C(C=C1)C2=CC3=C(C4=C(N3)C=CC(=C4)O)C5=C2C(=O)OC5=O IC50 ~ 50000 nM Poor binder T69991 Wee1-like protein kinase B36XQY 9-Hydroxy-2,6-dimethyl-4-phenylpyrrolo[3,4-c]carbazole-1,3-dione Investigative 11842996 C22H16N2O3 356.4 CN1C2=C(C=C(C=C2)O)C3=C1C=C(C4=C3C(=O)N(C4=O)C)C5=CC=CC=C5 IC50 ~ 50000 nM Poor binder T69991 Wee1-like protein kinase B4I1MG 8-Methyl-2-phenylamino-6-(2,3,6-trichloro-phenyl)-8H-pyrido[2,3-d]pyrimidin-7-one Investigative 44390925 C20H13Cl3N4O 431.7 CN1C2=NC(=NC=C2C=C(C1=O)C3=C(C=CC(=C3Cl)Cl)Cl)NC4=CC=CC=C4 IC50 ~ 50000 nM Poor binder T69991 Wee1-like protein kinase B51NMB 4-(Biphenyl-4-yl)-9-hydroxypyrrolo[3,4-c]carbazole-1,3(2H,6H)-dione Investigative 21980368 C26H16N2O3 404.4 C1=CC=C(C=C1)C2=CC=C(C=C2)C3=CC4=C(C5=C(N4)C=CC(=C5)O)C6=C3C(=O)NC6=O IC50 = 50118.72 nM Poor binder T69991 Wee1-like protein kinase B5HX6Y 6-(2,6-Dichloro-3-methyl-phenyl)-8-methyl-2-phenylamino-8H-pyrido[2,3-d]pyrimidin-7-one Investigative 44390942 C21H16Cl2N4O 411.3 CC1=C(C(=C(C=C1)Cl)C2=CC3=CN=C(N=C3N(C2=O)C)NC4=CC=CC=C4)Cl IC50 = 50000 nM Poor binder T69991 Wee1-like protein kinase B9U5OH 6-(2,6-Dichloro-3-methoxy-phenyl)-8-methyl-2-phenylamino-8H-pyrido[2,3-d]pyrimidin-7-one Investigative 44390958 C21H16Cl2N4O2 427.3 CN1C2=NC(=NC=C2C=C(C1=O)C3=C(C=CC(=C3Cl)OC)Cl)NC4=CC=CC=C4 IC50 ~ 50000 nM Poor binder T69991 Wee1-like protein kinase BB3CK6 6-(2,6-Dichloro-3,5-dimethoxy-phenyl)-8-methyl-2-phenylamino-8H-pyrido[2,3-d]pyrimidin-7-one Investigative 44390890 C22H18Cl2N4O3 457.3 CN1C2=NC(=NC=C2C=C(C1=O)C3=C(C(=CC(=C3Cl)OC)OC)Cl)NC4=CC=CC=C4 IC50 ~ 50000 nM Poor binder T69991 Wee1-like protein kinase BCM7U2 6-(2,6-Dichloro-4-methoxy-phenyl)-8-methyl-2-phenylamino-8H-pyrido[2,3-d]pyrimidin-7-one Investigative 44390982 C21H16Cl2N4O2 427.3 CN1C2=NC(=NC=C2C=C(C1=O)C3=C(C=C(C=C3Cl)OC)Cl)NC4=CC=CC=C4 IC50 ~ 50000 nM Poor binder T69991 Wee1-like protein kinase BEJ3K7 10-Hydroxy-4-phenylpyrrolo[3,4-c]carbazole-1,3(2H,6H)-dione Investigative 11842835 C20H12N2O3 328.3 C1=CC=C(C=C1)C2=CC3=C(C4=C(N3)C=CC=C4O)C5=C2C(=O)NC5=O IC50 ~ 50000 nM Poor binder T69991 Wee1-like protein kinase BENB07 5,8-Dimethyl-6-phenyl-2-phenylamino-8H-pyrido[2,3-d]pyrimidin-7-one Investigative 44390494 C21H18N4O 342.4 CC1=C(C(=O)N(C2=NC(=NC=C12)NC3=CC=CC=C3)C)C4=CC=CC=C4 IC50 ~ 50000 nM Poor binder T69991 Wee1-like protein kinase BJL3G6 6-(2-Chloro-6-trifluoromethyl-phenyl)-8-methyl-2-phenylamino-8H-pyrido[2,3-d]pyrimidin-7-one Investigative 44390956 C21H14ClF3N4O 430.8 CN1C2=NC(=NC=C2C=C(C1=O)C3=C(C=CC=C3Cl)C(F)(F)F)NC4=CC=CC=C4 IC50 ~ 50000 nM Poor binder T69991 Wee1-like protein kinase BK38EF 1,9-Dihydroxy-4-phenyl-1,6-dihydropyrrolo[3,4-c]carbazol-3(2H)-one Investigative 11842994 C20H14N2O3 330.3 C1=CC=C(C=C1)C2=CC3=C(C4=C(N3)C=CC(=C4)O)C5=C2C(=O)NC5O IC50 ~ 50000 nM Poor binder T69991 Wee1-like protein kinase BKLZ74 9-Hydroxy-4-[4-(trifluoromethyl)phenyl]pyrrolo[3,4-c]carbazole-1,3(2H,6H)-dione Investigative 11844754 C21H11F3N2O3 396.3 C1=CC(=CC=C1C2=CC3=C(C4=C(N3)C=CC(=C4)O)C5=C2C(=O)NC5=O)C(F)(F)F IC50 ~ 50000 nM Poor binder T69991 Wee1-like protein kinase BM04CK 6-(4-Methoxy-2,6-dimethyl-phenyl)-8-methyl-2-phenylamino-8H-pyrido[2,3-d]pyrimidin-7-one Investigative 44390861 C23H22N4O2 386.4 CC1=CC(=CC(=C1C2=CC3=CN=C(N=C3N(C2=O)C)NC4=CC=CC=C4)C)OC IC50 ~ 50000 nM Poor binder T69991 Wee1-like protein kinase BQX3F8 2-Amino-7-methyl-4-[(4-methylphenyl)methylamino]-9H-pyrimido[4,5-b]indol-6-ol Investigative 137659496 C19H19N5O 333.4 CC1=CC=C(C=C1)CNC2=NC(=NC3=C2C4=C(N3)C=C(C(=C4)O)C)N IC50 ~ 100000 nM Poor binder T69991 Wee1-like protein kinase BRO0Z3 N-[2,4-Dichloro-3-(8-methyl-7-oxo-2-phenylamino-7,8-dihydro-pyrido[2,3-d]pyrimidin-6-yl)-phenyl]-acetamide Investigative 44390929 C22H17Cl2N5O2 454.3 CC(=O)NC1=C(C(=C(C=C1)Cl)C2=CC3=CN=C(N=C3N(C2=O)C)NC4=CC=CC=C4)Cl IC50 ~ 50000 nM Poor binder T69991 Wee1-like protein kinase BSAZ84 6-(2,6-Dimethoxy-phenyl)-8-methyl-2-phenylamino-8H-pyrido[2,3-d]pyrimidin-7-one Investigative 44390924 C22H20N4O3 388.4 CN1C2=NC(=NC=C2C=C(C1=O)C3=C(C=CC=C3OC)OC)NC4=CC=CC=C4 IC50 ~ 50000 nM Poor binder T69991 Wee1-like protein kinase BUYW10 9-Hydroxy-4-[3-(trifluoromethyl)phenyl]pyrrolo[3,4-c]carbazole-1,3(2H,6H)-dione Investigative 11844614 C21H11F3N2O3 396.3 C1=CC(=CC(=C1)C(F)(F)F)C2=CC3=C(C4=C(N3)C=CC(=C4)O)C5=C2C(=O)NC5=O IC50 ~ 50000 nM Poor binder