TTD_Target_ID Target_Name TTD_Drug_ID Drug_Name Drug_Highest_Status Drug_PubchemID Molecular_Formula Molecular_Weight Canonical_SMILES Activity Binder_Type T71192 Leukotriene CysLT1 receptor B1KU8T 4,6-Dichloro-3-[(E)-3-(4-cyanobutoxy)-3-oxoprop-1-enyl]-1H-indole-2-carboxylic acid Investigative 127045343 C17H14Cl2N2O4 381.2 C1=C(C=C(C2=C1NC(=C2/C=C/C(=O)OCCCCC#N)C(=O)O)Cl)Cl IC50 ~ 100000 nM Poor binder T71192 Leukotriene CysLT1 receptor B1YJL7 4,6-Dichloro-3-[(E)-3-oxo-3-phenoxyprop-1-enyl]-1H-indole-2-carboxylic acid Investigative 127043253 C18H11Cl2NO4 376.2 C1=CC=C(C=C1)OC(=O)/C=C/C2=C(NC3=C2C(=CC(=C3)Cl)Cl)C(=O)O IC50 ~ 100000 nM Poor binder T71192 Leukotriene CysLT1 receptor B2M4ZE 4,6-Dichloro-3-[(E)-3-cyclohexyloxy-3-oxoprop-1-enyl]-1H-indole-2-carboxylic acid Investigative 127043410 C18H17Cl2NO4 382.2 C1CCC(CC1)OC(=O)/C=C/C2=C(NC3=C2C(=CC(=C3)Cl)Cl)C(=O)O IC50 ~ 100000 nM Poor binder T71192 Leukotriene CysLT1 receptor B5QNI1 4,6-Dichloro-3-[(E)-3-(cyclohexylmethoxy)-3-oxoprop-1-enyl]-1H-indole-2-carboxylic acid Investigative 127045334 C19H19Cl2NO4 396.3 C1CCC(CC1)COC(=O)/C=C/C2=C(NC3=C2C(=CC(=C3)Cl)Cl)C(=O)O IC50 ~ 100000 nM Poor binder T71192 Leukotriene CysLT1 receptor B6KUA2 4-Oxo-2-(4-phenoxyphenyl)-4H-chromene-8-carboxylic acid Investigative 49863641 C22H14O5 358.3 C1=CC=C(C=C1)OC2=CC=C(C=C2)C3=CC(=O)C4=C(O3)C(=CC=C4)C(=O)O IC50 = 55000 nM Poor binder T71192 Leukotriene CysLT1 receptor B7JU2N 4,6-Dichloro-3-[(E)-3-oxo-3-pentoxyprop-1-enyl]-1H-indole-2-carboxylic acid Investigative 127043411 C17H17Cl2NO4 370.2 CCCCCOC(=O)/C=C/C1=C(NC2=C1C(=CC(=C2)Cl)Cl)C(=O)O IC50 ~ 100000 nM Poor binder T71192 Leukotriene CysLT1 receptor B84FEX 4,6-Dichloro-3-[(E)-3-oxo-3-(3-phenylpropoxy)prop-1-enyl]-1H-indole-2-carboxylic acid Investigative 127043408 C21H17Cl2NO4 418.3 C1=CC=C(C=C1)CCCOC(=O)/C=C/C2=C(NC3=C2C(=CC(=C3)Cl)Cl)C(=O)O IC50 ~ 100000 nM Poor binder T71192 Leukotriene CysLT1 receptor BM5Q1T 4,6-Dichloro-3-[(E)-3-(4-methylpentoxy)-3-oxoprop-1-enyl]-1H-indole-2-carboxylic acid Investigative 127044872 C18H19Cl2NO4 384.2 CC(C)CCCOC(=O)/C=C/C1=C(NC2=C1C(=CC(=C2)Cl)Cl)C(=O)O IC50 ~ 100000 nM Poor binder T71192 Leukotriene CysLT1 receptor BMI51N 4,6-Dichloro-3-[(E)-3-oxo-3-phenylmethoxyprop-1-enyl]-1H-indole-2-carboxylic acid Investigative 127043406 C19H13Cl2NO4 390.2 C1=CC=C(C=C1)COC(=O)/C=C/C2=C(NC3=C2C(=CC(=C3)Cl)Cl)C(=O)O IC50 ~ 100000 nM Poor binder T71192 Leukotriene CysLT1 receptor BW4CJ9 4,6-Dichloro-3-[(E)-3-oxo-3-(4-phenylbutoxy)prop-1-enyl]-1H-indole-2-carboxylic acid Investigative 127043409 C22H19Cl2NO4 432.3 C1=CC=C(C=C1)CCCCOC(=O)/C=C/C2=C(NC3=C2C(=CC(=C3)Cl)Cl)C(=O)O IC50 ~ 100000 nM Poor binder T71192 Leukotriene CysLT1 receptor BYJC43 4,6-Dichloro-3-[(E)-3-oxo-3-(2-phenylethoxy)prop-1-enyl]-1H-indole-2-carboxylic acid Investigative 127043407 C20H15Cl2NO4 404.2 C1=CC=C(C=C1)CCOC(=O)/C=C/C2=C(NC3=C2C(=CC(=C3)Cl)Cl)C(=O)O IC50 ~ 100000 nM Poor binder