TTD_Target_ID	Target_Name	TTD_Drug_ID	Drug_Name	Drug_Highest_Status	Drug_PubchemID	Molecular_Formula	Molecular_Weight	Canonical_SMILES	Activity	Binder_Type
T73475	Matrix metalloproteinase-7	D0G1LL	1607004-34-1	Patented	74221072	C20H22F3N3O3	409.4	C1CC1[C@H](CC2=CC=C(C=C2)C(F)(F)F)C(=O)NC[C@@]3(C(=O)NC(=O)N3)C4CC4	IC50 ~ 100000 nM	Poor binder
T73475	Matrix metalloproteinase-7	D0N6ZA	US9206139, 4	Patented	74221131	C20H24F3N3O3	411.4	CC(C)[C@H](CC1=CC=C(C=C1)C(F)(F)F)C(=O)NC[C@@]2(C(=O)NC(=O)N2)C3CC3	IC50 ~ 100000 nM	Poor binder
T73475	Matrix metalloproteinase-7	D0UM5R	US9206139, 5	Patented	74221070	C19H22F3N3O3	397.4	CC(C)(CC1=CC=C(C=C1)C(F)(F)F)C(=O)NC[C@@]2(C(=O)NC(=O)N2)C3CC3	IC50 ~ 100000 nM	Poor binder
T73475	Matrix metalloproteinase-7	B01CEJ	(1R,2S)-1-({3-Fluoro-4-[(2-phenylquinolin-4-yl)methoxy]phenyl}methyl)-2-N-hydroxycyclopropane-1,2-dicarboxamide	Investigative	25138228	C28H24FN3O4	485.5	C1[C@@H]([C@@]1(CC2=CC(=C(C=C2)OCC3=CC(=NC4=CC=CC=C43)C5=CC=CC=C5)F)C(=O)N)C(=O)NO	Ki = 128000 nM	Poor binder
T73475	Matrix metalloproteinase-7	B09XSF	Hydroxamate deriv., 78	Investigative	24799779	C23H23N3O4	405.4	CC1=NC2=CC=CC=C2C(=C1)COC3=CC=C(C=C3)C[C@@]4(C[C@@H]4C(=O)NO)C(=O)N	Ki = 110000 nM	Poor binder
T73475	Matrix metalloproteinase-7	B12CRJ	N-[(2S)-1-(Dimethylamino)-3,3-dimethyl-1-oxobutan-2-yl]-2-[[formyl(hydroxy)amino]methyl]hexanamide	Investigative	22096205	C16H31N3O4	329.43	CCCCC(CN(C=O)O)C(=O)N[C@H](C(=O)N(C)C)C(C)(C)C	IC50 ~ 100000 nM	Poor binder
T73475	Matrix metalloproteinase-7	B1BUA7	2-Thioxo-5-hexyl-5-(4-biphenylyl)hexahydropyrimidine-4,6-dione	Investigative	44384941	C22H24N2O2S	380.5	CCCCCCC1(C(=O)NC(=S)NC1=O)C2=CC=C(C=C2)C3=CC=CC=C3	IC50 ~ 50000 nM	Poor binder
T73475	Matrix metalloproteinase-7	B1ZWH9	(2R)-N-[[(4R)-4-Cyclopropyl-2,5-dioxo-imidazolidin-4-yl]methyl]-2-[[4-(trifluoromethyl)phenyl]methyl]butanamide	Investigative	73603957	C19H22F3N3O3	397.4	CC[C@H](CC1=CC=C(C=C1)C(F)(F)F)C(=O)NC[C@@]2(C(=O)NC(=O)N2)C3CC3	IC50 ~ 100000 nM	Poor binder
T73475	Matrix metalloproteinase-7	B3I0TD	5-Benzyloxymethyl-5-(4-phenoxy-phenyl)-pyrimidine-2,4,6-trione	Investigative	9823182	C24H20N2O5	416.4	C1=CC=C(C=C1)COCC2(C(=O)NC(=O)NC2=O)C3=CC=C(C=C3)OC4=CC=CC=C4	IC50 ~ 50000 nM	Poor binder
T73475	Matrix metalloproteinase-7	B41WTH	5-Hexyl-5-(4-phenoxyphenyl)hexahydropyrimidine-2,4,6-trione	Investigative	9886177	C22H24N2O4	380.4	CCCCCCC1(C(=O)NC(=O)NC1=O)C2=CC=C(C=C2)OC3=CC=CC=C3	IC50 ~ 50000 nM	Poor binder
T73475	Matrix metalloproteinase-7	B4M7LO	4-(Thiiran-2-ylmethylsulfonyl)phenyl propane-2-sulfonate	Investigative	53323418	C13H18O5S3	350.5	CC(C)CS(=O)(=O)OC1=CC=C(C=C1)S(=O)(=O)CC2CS2	Ki = 120000 nM	Poor binder
T73475	Matrix metalloproteinase-7	B4VDK7	Epicatechin 3-O-(4-O-methylgallate)	Investigative	467297	C23H20O10	456.4	COC1=C(C=C(C=C1O)C(=O)O[C@@H]2CC3=C(C=C(C=C3O[C@@H]2C4=CC(=C(C=C4)O)O)O)O)O	IC50 ~ 100000 nM	Poor binder
T73475	Matrix metalloproteinase-7	B4ZP8S	1-[[2-(4-Chlorophenoxy)acetyl]amino]-3-(4-cyclohexylbutyl)thiourea	Investigative	73349535	C19H28ClN3O2S	398	C1CCC(CC1)CCCCNC(=S)NNC(=O)COC2=CC=C(C=C2)Cl	IC50 ~ 100000 nM	Poor binder
T73475	Matrix metalloproteinase-7	B65KHL	(2R)-N-[[(4R)-4-Cyclopropyl-2,5-dioxoimidazolidin-4-yl]methyl]-2-methyl-3-[4-(trifluoromethyl)phenyl]propanamide	Investigative	74221194	C18H20F3N3O3	383.4	C[C@H](CC1=CC=C(C=C1)C(F)(F)F)C(=O)NC[C@@]2(C(=O)NC(=O)N2)C3CC3	IC50 ~ 100000 nM	Poor binder
T73475	Matrix metalloproteinase-7	B6C3IU	Biphenylsulfonamide carboxylate, 9	Investigative	24901479	C17H19NO4S	333.4	CC(C)[C@@H](C(=O)O)NS(=O)(=O)C1=CC=C(C=C1)C2=CC=CC=C2	IC50 = 71000 nM	Poor binder
T73475	Matrix metalloproteinase-7	B6C9GT	2-[(4-Phenoxyphenyl)sulfonylmethyl]thiirane	Investigative	9883002	C15H14O3S2	306.4	C1C(S1)CS(=O)(=O)C2=CC=C(C=C2)OC3=CC=CC=C3	Ki = 96000 nM	Poor binder
T73475	Matrix metalloproteinase-7	B6O4DQ	(E)-N-Hydroxy-3-[4-(trifluoromethyl)phenyl]acrylamide	Investigative	53374826	C10H8F3NO2	231.17	C1=CC(=CC=C1/C=C/C(=O)NO)C(F)(F)F	IC50 ~ 100000 nM	Poor binder
T73475	Matrix metalloproteinase-7	B75TPB	5-(2-Hydroxyethyl)-5-(4-phenoxyphenyl)hexahydropyrimidine-2,4,6-trione	Investigative	9862764	C18H16N2O5	340.3	C1=CC=C(C=C1)OC2=CC=C(C=C2)C3(C(=O)NC(=O)NC3=O)CCO	IC50 ~ 50000 nM	Poor binder
T73475	Matrix metalloproteinase-7	B76AGQ	4''-Methylepigallocatechin gallate	Investigative	401129	C23H20O11	472.4	COC1=C(C=C(C=C1O)C(=O)O[C@@H]2CC3=C(C=C(C=C3O[C@@H]2C4=CC(=C(C(=C4)O)O)O)O)O)O	IC50 = 72000 nM	Poor binder
T73475	Matrix metalloproteinase-7	B76AON	4-Phenoxy-N-[(1S,2R)-2-sulfanylcyclopentyl]benzenesulfonamide	Investigative	71682767	C17H19NO3S2	349.5	C1C[C@@H]([C@@H](C1)S)NS(=O)(=O)C2=CC=C(C=C2)OC3=CC=CC=C3	Ki ~ 100000 nM	Poor binder
T73475	Matrix metalloproteinase-7	B8ZWO6	(2R,3R)-4-(2-(3-Chlorophenyl)pyrrolidin-1-yl)-2,3-dihydroxy-4-oxo-N-(2-(thiophen-2-yl)ethyl)butanamide	Investigative	11697504	C20H23ClN2O4S	422.9	C1CC(N(C1)C(=O)[C@@H]([C@H](C(=O)NCCC2=CC=CS2)O)O)C3=CC(=CC=C3)Cl	Ki ~ 50000 nM	Poor binder
T73475	Matrix metalloproteinase-7	BBX76W	alpha-Arylsulfonylamino hydroxamate 3S	Investigative	10741133	C17H19BrN2O4S	427.3	CC(C)[C@@H](C(=O)NO)NS(=O)(=O)C1=CC=C(C=C1)C2=CC=C(C=C2)Br	IC50 = 78000 nM	Poor binder
T73475	Matrix metalloproteinase-7	BC6KT9	(4S)-5-[[(2S)-1-Amino-3-carboxy-1-oxopropan-2-yl]amino]-5-oxo-4-[3-[4-(4-phenylthiophen-2-yl)phenyl]propanoylamino]pentanoic acid	Investigative	69922083	C28H29N3O7S	551.6	C1=CC=C(C=C1)C2=CSC(=C2)C3=CC=C(C=C3)CCC(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N	Ki ~ 100000 nM	Poor binder
T73475	Matrix metalloproteinase-7	BGM15D	(2R,3S)-2-(3,4-Dihydroxyphenyl)-5,7-dihydroxychroman-3-yl 3,4-dihydroxy-5-methoxybenzoate	Investigative	42623564	C23H20O10	456.4	COC1=CC(=CC(=C1O)O)C(=O)O[C@H]2CC3=C(C=C(C=C3O[C@@H]2C4=CC(=C(C=C4)O)O)O)O	IC50 ~ 100000 nM	Poor binder
T73475	Matrix metalloproteinase-7	BGN20Z	(S)-3-Methyl-2-(8-(thiazol-2-yl)dibenzo[b,d]furan-3-sulfonamido)butanoic acid	Investigative	56835063	C20H18N2O5S2	430.5	CC(C)[C@@H](C(=O)O)NS(=O)(=O)C1=CC2=C(C=C1)C3=C(O2)C=CC(=C3)C4=NC=CS4	IC50 = 57700 nM	Poor binder
T73475	Matrix metalloproteinase-7	BHKF38	Epicatechin 3-O-(3-O-methylgallate)	Investigative	467296	C23H20O10	456.4	COC1=CC(=CC(=C1O)O)C(=O)O[C@@H]2CC3=C(C=C(C=C3O[C@@H]2C4=CC(=C(C=C4)O)O)O)O	IC50 ~ 100000 nM	Poor binder
T73475	Matrix metalloproteinase-7	BHL76P	(2R,3S)-2-(3,4-Dihydroxyphenyl)-5,7-dihydroxychroman-3-yl 3,5-dihydroxy-4-methoxybenzoate	Investigative	42623563	C23H20O10	456.4	COC1=C(C=C(C=C1O)C(=O)O[C@H]2CC3=C(C=C(C=C3O[C@@H]2C4=CC(=C(C=C4)O)O)O)O)O	IC50 ~ 100000 nM	Poor binder
T73475	Matrix metalloproteinase-7	BI3S2D	2-(3''-Bromo-biphenyl-4-sulfonylamino)-3-methyl-butyric acid	Investigative	10692994	C17H18BrNO4S	412.3	CC(C)[C@@H](C(=O)O)NS(=O)(=O)C1=CC=C(C=C1)C2=CC(=CC=C2)Br	IC50 = 100000 nM	Poor binder
T73475	Matrix metalloproteinase-7	BIFP05	2-Amino-5-(4-((thiiran-2-ylmethyl)sulfonyl)phenoxy)phenol	Investigative	54757202	C15H15NO4S2	337.4	C1C(S1)CS(=O)(=O)C2=CC=C(C=C2)OC3=CC(=C(C=C3)N)O	Ki = 116000 nM	Poor binder
T73475	Matrix metalloproteinase-7	BJ0K8P	(2S)-2-[[4-(4-Bromophenyl)phenyl]sulfonylamino]-3-phenylpropanoic acid	Investigative	10551910	C21H18BrNO4S	460.3	C1=CC=C(C=C1)C[C@@H](C(=O)O)NS(=O)(=O)C2=CC=C(C=C2)C3=CC=C(C=C3)Br	IC50 = 100000 nM	Poor binder
T73475	Matrix metalloproteinase-7	BJV8M0	((R)-1-{4-[2-(4-Methoxy-phenyl)-ethyl]-benzenesulfonylamino}-2-methyl-propyl)-phosphonic acid	Investigative	44422749	C19H26NO6PS	427.5	CC(C)[C@H](NS(=O)(=O)C1=CC=C(C=C1)CCC2=CC=C(C=C2)OC)P(=O)(O)O	IC50 = 130000 nM	Poor binder
T73475	Matrix metalloproteinase-7	BN7RG4	1,5-Dimethyl-5-(4-phenoxyphenyl)hexahydropyrimidine-2,4,6-trione	Investigative	44384994	C18H16N2O4	324.3	CC1(C(=O)NC(=O)N(C1=O)C)C2=CC=C(C=C2)OC3=CC=CC=C3	IC50 ~ 50000 nM	Poor binder
T73475	Matrix metalloproteinase-7	BR0S8L	5-Methyl-5-(4-phenoxy-phenyl)-pyrimidine-2,4,6-trione	Investigative	1836	C17H14N2O4	310.3	CC1(C(=O)NC(=O)NC1=O)C2=CC=C(C=C2)OC3=CC=CC=C3	IC50 ~ 50000 nM	Poor binder
T73475	Matrix metalloproteinase-7	BRD5Z7	(2r,3r)-4-[4-(2-Chlorophenyl)piperazin-1-Yl]-2,3-Dihydroxy-4-Oxo-N-(2-Thiophen-2-Ylethyl)butanamide	Investigative	11640694	C20H24ClN3O4S	437.9	C1CN(CCN1C2=CC=CC=C2Cl)C(=O)[C@@H]([C@H](C(=O)NCCC3=CC=CS3)O)O	Ki ~ 60000 nM	Poor binder
T73475	Matrix metalloproteinase-7	BS1DV9	N-[(1S,2S)-2-Sulfanylcyclopentyl]benzenesulfonamide	Investigative	71682913	C11H15NO2S2	257.399	C1C[C@@H]([C@H](C1)S)NS(=O)(=O)C2=CC=CC=C2	Ki ~ 50000 nM	Poor binder
T73475	Matrix metalloproteinase-7	BS6RN3	[(R)-2-Methyl-1-(4-phenethyl-benzenesulfonylamino)-propyl]-phosphonic acid	Investigative	44422744	C18H24NO5PS	397.4	CC(C)[C@H](NS(=O)(=O)C1=CC=C(C=C1)CCC2=CC=CC=C2)P(=O)(O)O	IC50 = 50000 nM	Poor binder
T73475	Matrix metalloproteinase-7	BT16SP	Benzyl 6-Benzyl-5,7-Dioxo-6,7-Dihydro-5h-[1,3]thiazolo[3,2-C]pyrimidine-2-Carboxylate	Investigative	9896504	C21H16N2O4S	392.4	C1=CC=C(C=C1)CN2C(=O)C=C3N(C2=O)C=C(S3)C(=O)OCC4=CC=CC=C4	IC50 ~ 100000 nM	Poor binder
T73475	Matrix metalloproteinase-7	BU72GZ	N-[(3S,4S)-1-(6-Aminohexanoyl)-4-hydroxypyrrolidin-3-yl]-4-phenoxybenzenesulfonamide;hydrochloride	Investigative	71680867	C22H30ClN3O5S	484	C1[C@@H]([C@H](CN1C(=O)CCCCCN)O)NS(=O)(=O)C2=CC=C(C=C2)OC3=CC=CC=C3.Cl	Ki ~ 100000 nM	Poor binder
T73475	Matrix metalloproteinase-7	BU97NY	(2R,3R)-N-(Benzofuran-2-ylmethyl)-2,3-dihydroxy-4-oxo-4-(2-phenylpyrrolidin-1-yl)butanamide	Investigative	11517085	C23H24N2O5	408.4	C1CC(N(C1)C(=O)[C@@H]([C@H](C(=O)NCC2=CC3=CC=CC=C3O2)O)O)C4=CC=CC=C4	Ki ~ 50000 nM	Poor binder
T73475	Matrix metalloproteinase-7	BVL83B	N-(2beta-Mercaptocyclopentane-1alpha-yl)-4-phenoxybenzenesulfonamide	Investigative	71682915	C17H19NO3S2	349.5	C1C[C@@H]([C@H](C1)S)NS(=O)(=O)C2=CC=C(C=C2)OC3=CC=CC=C3	Ki ~ 100000 nM	Poor binder
T73475	Matrix metalloproteinase-7	BVQM95	5-Methyl-5-(4-octyloxy-benzyl)-pyrimidine-2,4,6-trione	Investigative	44384940	C20H28N2O4	360.4	CCCCCCCCOC1=CC=C(C=C1)CC2(C(=O)NC(=O)NC2=O)C	IC50 ~ 50000 nM	Poor binder
T73475	Matrix metalloproteinase-7	BWMA52	(2S)-2-Amino-5-(diaminomethylideneamino)-N-[4-[4-(thiiran-2-ylmethylsulfonyl)phenoxy]phenyl]pentanamide	Investigative	54669766	C21H27N5O4S2	477.6	C1C(S1)CS(=O)(=O)C2=CC=C(C=C2)OC3=CC=C(C=C3)NC(=O)[C@H](CCCN=C(N)N)N	Ki = 160000 nM	Poor binder
T73475	Matrix metalloproteinase-7	BZRO48	2-[[4-(4-Bromophenyl)phenyl]sulfonylamino]acetic Acid	Investigative	10832925	C14H12BrNO4S	370.22	C1=CC(=CC=C1C2=CC=C(C=C2)Br)S(=O)(=O)NCC(=O)O	IC50 = 77000 nM	Poor binder
T73475	Matrix metalloproteinase-7	D04GOO	N1,N3-bis(3-methoxybenzyl)isophthalamide	Investigative	10111838	C24H24N2O4	404.5	COC1=CC=CC(=C1)CNC(=O)C2=CC(=CC=C2)C(=O)NCC3=CC(=CC=C3)OC	IC50 ~ 100000 nM	Poor binder
T73475	Matrix metalloproteinase-7	D07LTB	5-(4-Phenoxy-phenyl)-pyrimidine-2,4,6-trione	Investigative	11673778	C16H12N2O4	296.28	C1=CC=C(C=C1)OC2=CC=C(C=C2)C3C(=O)NC(=O)NC3=O	IC50 ~ 50000 nM	Poor binder
T73475	Matrix metalloproteinase-7	D09GIL	5-Methyl-5-phenyl-pyrimidine-2,4,6-trione	Investigative	66160	C11H10N2O3	218.21	CC1(C(=O)NC(=O)NC1=O)C2=CC=CC=C2	IC50 ~ 50000 nM	Poor binder
T73475	Matrix metalloproteinase-7	D0B0UI	Methotrexate gamma-hydroxamic acid	Investigative	44428664	C20H23N9O5	469.5	CN(CC1=CN=C2C(=N1)C(=NC(=N2)N)N)C3=CC=C(C=C3)C(=O)N[C@@H](CCC(=O)NO)C(=O)O	IC50 = 100000 nM	Poor binder
T73475	Matrix metalloproteinase-7	D0G3YZ	(+/-)5-(biphenyl-4-yl)-3-hydroxypentanoic acid	Investigative	11391583	C17H18O3	270.32	C1=CC=C(C=C1)C2=CC=C(C=C2)CCC(CC(=O)O)O	IC50 ~ 98000 nM	Poor binder
T73475	Matrix metalloproteinase-7	D0K4TI	5-Hexyl-5-phenyl-pyrimidine-2,4,6-trione	Investigative	49292	C16H20N2O3	288.34	CCCCCCC1(C(=O)NC(=O)NC1=O)C2=CC=CC=C2	IC50 ~ 50000 nM	Poor binder
T73475	Matrix metalloproteinase-7	D0N8YA	Bb-3497	Investigative	159596	C16H31N3O4	329.43	CCCC[C@H](CN(C=O)O)C(=O)N[C@H](C(=O)N(C)C)C(C)(C)C	IC50 ~ 100000 nM	Poor binder
T73475	Matrix metalloproteinase-7	D0Q4TA	ARP100	Investigative	10044321	C17H20N2O5S	364.4	CC(C)ON(CC(=O)NO)S(=O)(=O)C1=CC=C(C=C1)C2=CC=CC=C2	IC50 ~ 50000 nM	Poor binder
T73475	Matrix metalloproteinase-7	D0Q9LC	5-Biphenyl-4-yl-5-hexyl-pyrimidine-2,4,6-trione	Investigative	44385624	C22H24N2O3	364.4	CCCCCCC1(C(=O)NC(=O)NC1=O)C2=CC=C(C=C2)C3=CC=CC=C3	IC50 ~ 50000 nM	Poor binder
T73475	Matrix metalloproteinase-7	D0Y7NV	5-Biphenyl-4-yl-5-ethyl-pyrimidine-2,4,6-trione	Investigative	2220392	C18H16N2O3	308.3	CCC1(C(=O)NC(=O)NC1=O)C2=CC=C(C=C2)C3=CC=CC=C3	IC50 ~ 50000 nM	Poor binder