TTD_Target_ID Target_Name TTD_Drug_ID Drug_Name Drug_Highest_Status Drug_PubchemID Molecular_Formula Molecular_Weight Canonical_SMILES Activity Binder_Type T73694 Tyrosine-protein kinase BRK B0WLH8 N-(7-Methoxyquinolin-6-yl)thieno[3,2-d]pyrimidine-7-carboxamide Investigative 58056356 C17H12N4O2S 336.4 COC1=C(C=C2C=CC=NC2=C1)NC(=O)C3=CSC4=CN=CN=C43 IC50 ~ 50000 nM Poor binder T73694 Tyrosine-protein kinase BRK B43WPI 3-[(E)-2-(4-Chlorophenyl)ethenyl]-N-[(2R)-2,3-dihydroxypropyl]-4-methoxybenzamide Investigative 57325478 C19H20ClNO4 361.8 COC1=C(C=C(C=C1)C(=O)NC[C@H](CO)O)/C=C/C2=CC=C(C=C2)Cl IC50 ~ 50000 nM Poor binder T73694 Tyrosine-protein kinase BRK B4XPQ6 5-[(2-Hydroxy-5-iodo-3-methoxyphenyl)methylideneamino]-1,3-dihydrobenzimidazol-2-one Investigative 136044162 C15H12IN3O3 409.18 COC1=CC(=CC(=C1O)C=NC2=CC3=C(C=C2)NC(=O)N3)I IC50 = 58100 nM Poor binder T73694 Tyrosine-protein kinase BRK B58TMC [6-Chloro-4-methyl-3-[[3-(methylsulfamoylamino)phenyl]methyl]-2-oxochromen-7-yl] N,N-dimethylcarbamate Investigative 24753787 C21H22ClN3O6S 479.9 CC1=C(C(=O)OC2=CC(=C(C=C12)Cl)OC(=O)N(C)C)CC3=CC(=CC=C3)NS(=O)(=O)NC IC50 ~ 50000 nM Poor binder T73694 Tyrosine-protein kinase BRK B7BJ1F 5-{[(5-Bromo-2-hydroxyphenyl)methylidene]amino}-2,3-dihydro-1H-1,3-benzodiazol-2-one Investigative 2351464 C14H10BrN3O2 332.15 C1=CC2=C(C=C1N=CC3=C(C=CC(=C3)Br)O)NC(=O)N2 IC50 ~ 100000 nM Poor binder T73694 Tyrosine-protein kinase BRK B7N1WR 3-[(E)-2-(4-Chlorophenyl)ethenyl]-N-[(2S)-2,3-dihydroxypropyl]-4-methoxybenzamide Investigative 57325479 C19H20ClNO4 361.8 COC1=C(C=C(C=C1)C(=O)NC[C@@H](CO)O)/C=C/C2=CC=C(C=C2)Cl IC50 ~ 50000 nM Poor binder T73694 Tyrosine-protein kinase BRK B7ZDB8 (R)-6-(1-(2,6-Dichloro-3-fluorophenyl)ethoxy)quinoline Investigative 46232443 C17H12Cl2FNO 336.2 C[C@H](C1=C(C=CC(=C1Cl)F)Cl)OC2=CC3=C(C=C2)N=CC=C3 IC50 ~ 50000 nM Poor binder T73694 Tyrosine-protein kinase BRK BE5YT4 5-[(5-Chloro-3-ethoxy-2-hydroxyphenyl)methylideneamino]-1,3-dihydrobenzimidazol-2-one Investigative 136044171 C16H14ClN3O3 331.75 CCOC1=CC(=CC(=C1O)C=NC2=CC3=C(C=C2)NC(=O)N3)Cl IC50 = 51250 nM Poor binder T73694 Tyrosine-protein kinase BRK BEJ8D5 Tyrphostin AG 808 Investigative 5329275 C18H12N2O3 304.3 C1=CC=C2C(=C1)C(=CN2)/C=C(\\C#N)/C(=O)C3=CC(=C(C=C3)O)O IC50 = 53240 nM Poor binder T73694 Tyrosine-protein kinase BRK BPV4H6 2-(6-((R)-1-(2,6-Dichloro-3-fluorophenyl)ethoxy)quinolin-3-yl)cyclopropanecarboxamide Investigative 46232556 C21H17Cl2FN2O2 419.3 C[C@H](C1=C(C=CC(=C1Cl)F)Cl)OC2=CC3=CC(=CN=C3C=C2)C4CC4C(=O)N IC50 ~ 50000 nM Poor binder T73694 Tyrosine-protein kinase BRK BQG2W3 5-[(5-Chloro-2-hydroxy-3-methoxyphenyl)methylideneamino]-1,3-dihydrobenzimidazol-2-one Investigative 135406083 C15H12ClN3O3 317.72 COC1=CC(=CC(=C1O)C=NC2=CC3=C(C=C2)NC(=O)N3)Cl IC50 = 74040 nM Poor binder