TTD_Target_ID	Target_Name	TTD_Drug_ID	Drug_Name	Drug_Highest_Status	Drug_PubchemID	Molecular_Formula	Molecular_Weight	Canonical_SMILES	Activity	Binder_Type
T77548	Metabotropic glutamate receptor 8	D0D4OW	PMID25435285-Compound-15	Patented	57338826	C15H15Cl2NO6	376.2	C1=CC(=C(C=C1CO[C@@H]2[C@H]([C@H]3[C@@H]([C@H]3[C@@]2(C(=O)O)N)C(=O)O)O)Cl)Cl	EC50 ~ 50000 nM	Poor binder
T77548	Metabotropic glutamate receptor 8	B1RS0P	(2S)-2-Amino-4-[hydroxy-[hydroxy-(4-hydroxy-3-nitrophenyl)methyl]phosphoryl]butanoic acid	Investigative	46918015	C11H15N2O8P	334.22	C1=CC(=C(C=C1C(O)P(=O)(CC[C@@H](C(=O)O)N)O)[N+](=O)[O-])O	EC50 = 73000 nM	Poor binder
T77548	Metabotropic glutamate receptor 8	B1ST5P	(2S)-2-Amino-4-[hydroxy-[hydroxy-(4-methylsulfonylphenyl)methyl]phosphoryl]butanoic acid	Investigative	24780092	C12H18NO7PS	351.31	CS(=O)(=O)C1=CC=C(C=C1)C(O)P(=O)(CC[C@@H](C(=O)O)N)O	EC50 ~ 100000 nM	Poor binder
T77548	Metabotropic glutamate receptor 8	B20YKD	4-[[[(3S)-3-Amino-3-carboxypropyl]-hydroxyphosphoryl]-hydroxymethyl]benzoic acid	Investigative	24780088	C12H16NO7P	317.23	C1=CC(=CC=C1C(O)P(=O)(CC[C@@H](C(=O)O)N)O)C(=O)O	EC50 = 141000 nM	Poor binder
T77548	Metabotropic glutamate receptor 8	B9H5SN	(2S)-2-Amino-4-[hydroxy-[hydroxy-(4-morpholin-4-yl-3-nitrophenyl)methyl]phosphoryl]butanoic acid	Investigative	57765549	C15H22N3O8P	403.32	C1COCCN1C2=C(C=C(C=C2)C(O)P(=O)(CC[C@@H](C(=O)O)N)O)[N+](=O)[O-]	EC50 ~ 100000 nM	Poor binder
T77548	Metabotropic glutamate receptor 8	BF0J1K	(2S)-2-Amino-4-[hydroxy-[hydroxy-(2-oxo-1H-pyridin-4-yl)methyl]phosphoryl]butanoic acid	Investigative	137651881	C10H15N2O6P	290.21	C1=CNC(=O)C=C1C(O)P(=O)(CC[C@@H](C(=O)O)N)O	EC50 = 81000 nM	Poor binder
T77548	Metabotropic glutamate receptor 8	BGBD73	3-[[[(3S)-3-Amino-3-carboxypropyl]-hydroxyphosphoryl]-hydroxymethyl]benzoic acid	Investigative	24779948	C12H16NO7P	317.23	C1=CC(=CC(=C1)C(=O)O)C(O)P(=O)(CC[C@@H](C(=O)O)N)O	EC50 = 125000 nM	Poor binder
T77548	Metabotropic glutamate receptor 8	BGP8O9	(+)-(1R,2R,4S,5S,6S)-4-Amino-2-thiabicyclo[3.1.0]hexane-4,6-dicarboxylic acid 2-oxide	Investigative	10353365	C7H9NO5S	219.22	C1[C@]([C@@H]2[C@H]([C@@H]2S1=O)C(=O)O)(C(=O)O)N	EC50 ~ 100000 nM	Poor binder
T77548	Metabotropic glutamate receptor 8	BXCW27	(2S)-2-Amino-4-[hydroxy-[hydroxy-(4-methoxyphenyl)methyl]phosphoryl]butanoic acid	Investigative	137644345	C12H18NO6P	303.25	COC1=CC=C(C=C1)C(O)P(=O)(CC[C@@H](C(=O)O)N)O	EC50 = 61000 nM	Poor binder
T77548	Metabotropic glutamate receptor 8	D01EVA	CPCCOEt	Investigative	6278000	C13H13NO4	247.25	CCOC(=O)C12CC1/C(=N\\O)/C3=CC=CC=C3O2	Ki ~ 100000 nM	Poor binder
T77548	Metabotropic glutamate receptor 8	D05TFE	SIB-1757	Investigative	5218788	C12H11N3O	213.23	.	Ki ~ 100000 nM	Poor binder
T77548	Metabotropic glutamate receptor 8	D0EK6P	(2R,4R)-4-aminopyrrolidine-2,4-dicarboxylate	Investigative	5310984	C6H10N2O4	174.15	C1[C@@H](NC[C@]1(C(=O)O)N)C(=O)O	Ki ~ 100000 nM	Poor binder
T77548	Metabotropic glutamate receptor 8	D0IO8J	2-methyl-6-(phenylethynyl)pyridine	Investigative	3025961	C14H11N	193.24	CC1=NC(=CC=C1)C#CC2=CC=CC=C2	Ki ~ 100000 nM	Poor binder
T77548	Metabotropic glutamate receptor 8	D0Q6VH	SIB-1893	Investigative	5311432	C14H13N	195.26	CC1=NC(=CC=C1)/C=C/C2=CC=CC=C2	Ki ~ 100000 nM	Poor binder