TTD_Target_ID Target_Name TTD_Drug_ID Drug_Name Drug_Highest_Status Drug_PubchemID Molecular_Formula Molecular_Weight Canonical_SMILES Activity Binder_Type T77613 Phosphodiesterase 1B D0SH7F BC11-28 Patented 3257208 C25H19FN4 394.4 CC1=CC=CC=C1NC2=C3C(=CN(C3=NC=N2)C4=CC=C(C=C4)F)C5=CC=CC=C5 IC50 ~ 100000 nM Poor binder T77613 Phosphodiesterase 1B D0Z7YQ AC1M1SP5 Patented 2155273 C16H18N2O2S2 334.5 CCCSC1=NC2=C(C(=O)N1C3=CC=CC=C3OC)SCC2 IC50 ~ 100000 nM Poor binder T77613 Phosphodiesterase 1B B97HAY 6-(3,4-Dimethoxyphenyl)-3-(2-methoxyphenyl)-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine Investigative 662965 C19H18N4O3S 382.4 COC1=C(C=C(C=C1)C2=NN3C(=NN=C3SC2)C4=CC=CC=C4OC)OC IC50 ~ 50000 nM Poor binder T77613 Phosphodiesterase 1B B9V3TH N,N-Diethyl-3-methyl-1-(2-methylphenyl)-6-(thiophen-2-yl)-1H-pyrazolo[3,4-b]pyridine-4-carboxamide Investigative 2409032 C23H24N4OS 404.5 CCN(CC)C(=O)C1=CC(=NC2=C1C(=NN2C3=CC=CC=C3C)C)C4=CC=CS4 IC50 ~ 100000 nM Poor binder T77613 Phosphodiesterase 1B BO3YQ5 2-(Butylthio)-3-phenyl-6,7-dihydrothieno[3,2-d]pyrimidin-4(3H)-one Investigative 2155145 C16H18N2OS2 318.5 CCCCSC1=NC2=C(C(=O)N1C3=CC=CC=C3)SCC2 IC50 = 90000 nM Poor binder T77613 Phosphodiesterase 1B BR5L8O 2-(Propylthio)-3-(p-tolyl)-6,7-dihydrothieno[3,2-d]pyrimidin-4(3H)-one Investigative 2052838 C16H18N2OS2 318.5 CCCSC1=NC2=C(C(=O)N1C3=CC=C(C=C3)C)SCC2 IC50 ~ 100000 nM Poor binder