TTD_Target_ID	Target_Name	TTD_Drug_ID	Drug_Name	Drug_Highest_Status	Drug_PubchemID	Molecular_Formula	Molecular_Weight	Canonical_SMILES	Activity	Binder_Type
T79961	Muscarinic acetylcholine receptor M5	D0U7BW	Carbachol	Approved	2551	C6H15N2O2+	147.2	C[N+](C)(C)CCOC(=O)N	Ki = 69183.1 nM	Poor binder
T79961	Muscarinic acetylcholine receptor M5	D07EFM	Arecoline	Phase 1	2230	C8H13NO2	155.19	CN1CCC=C(C1)C(=O)OC	Ki = 56000 nM	Poor binder
T79961	Muscarinic acetylcholine receptor M5	B01URL	N-Cyclohexyl-2-(4-propanoylpiperazin-1-yl)acetamide	Investigative	49853778	C15H27N3O2	281.39	CCC(=O)N1CCN(CC1)CC(=O)NC2CCCCC2	IC50 ~ 100000 nM	Poor binder
T79961	Muscarinic acetylcholine receptor M5	B0UJY6	N-[2-(Dimethylamino)ethyl]-N-methyl-1-(3-pyridinylmethylene)-1H-indene-3-carboxamide	Investigative	44274432	C21H23N3O	333.4	CN(C)CCN(C)C(=O)C1=C/C(=C\\C2=CN=CC=C2)/C3=CC=CC=C31	Ki = 53703.18 nM	Poor binder
T79961	Muscarinic acetylcholine receptor M5	B1ELB7	Pyrrolidine, 2-(2-furanyl)-1-methyl-, (2R)-	Investigative	24894515	C9H13NO	151.21	CN1CCC[C@@H]1C2=CC=CO2	Ki = 75857.76 nM	Poor binder
T79961	Muscarinic acetylcholine receptor M5	B1Z0TB	N,N,N-Trimethyl-alpha-(2-oxooxazolidine-5beta-yl)methaneaminium	Investigative	73349591	C7H15N2O2+	159.21	C[N+](C)(C)C[C@@H]1CNC(=O)O1	Ki ~ 100000 nM	Poor binder
T79961	Muscarinic acetylcholine receptor M5	B24RXD	3-Methoxy-4-[2-[2-[2-[2-[[4-(1-methyl-3,6-dihydro-2H-pyridin-5-yl)-1,2,5-thiadiazol-3-yl]oxy]ethoxy]ethoxy]ethoxy]ethoxy]-1,2,5-thiadiazole;hydrochloride	Investigative	10142923	C19H30ClN5O6S2	524.1	CN1CCC=C(C1)C2=NSN=C2OCCOCCOCCOCCOC3=NSN=C3OC.Cl	EC50 = 199526.23 nM	Poor binder
T79961	Muscarinic acetylcholine receptor M5	B27QAO	6-Fluoro-3-[1-[1-[[2-(trifluoromethyl)phenyl]methyl]piperidin-4-yl]piperidin-4-yl]-1H-benzimidazol-2-one	Investigative	44579457	C25H28F4N4O	476.5	C1CN(CCC1N2CCC(CC2)N3C4=C(C=C(C=C4)F)NC3=O)CC5=CC=CC=C5C(F)(F)F	EC50 ~ 50000 nM	Poor binder
T79961	Muscarinic acetylcholine receptor M5	B2DOR6	6,7,8,9-Tetrahydro-[1,2,5]thiadiazolo[3,4-h]isoquinoline	Investigative	14660293	C9H9N3S	191.26	C1CNCC2=C1C=CC3=NSN=C23	IC50 = 100000 nM	Poor binder
T79961	Muscarinic acetylcholine receptor M5	B2V7EP	2-[[4-[4-(2-Oxo-3H-benzimidazol-1-yl)piperidin-1-yl]piperidin-1-yl]methyl]benzonitrile	Investigative	44578978	C25H29N5O	415.5	C1CN(CCC1N2CCC(CC2)N3C4=CC=CC=C4NC3=O)CC5=CC=CC=C5C#N	EC50 ~ 50000 nM	Poor binder
T79961	Muscarinic acetylcholine receptor M5	B3K8HA	Pyrrolidine, 2-(2-furanyl)-1-methyl-, (2S)-	Investigative	24894514	C9H13NO	151.21	CN1CCC[C@H]1C2=CC=CO2	Ki = 63095.73 nM	Poor binder
T79961	Muscarinic acetylcholine receptor M5	B3OJ9Q	Ethyl 1-[2-(4-methoxyphenyl)ethyl]-4-phenyl-3,6-dihydro-2H-pyridine-5-carboxylate	Investigative	71574179	C23H27NO3	365.5	CCOC(=O)C1=C(CCN(C1)CCC2=CC=C(C=C2)OC)C3=CC=CC=C3	Ki ~ 100000 nM	Poor binder
T79961	Muscarinic acetylcholine receptor M5	B40KXW	Trimethyl-[[(2R,3R)-3-methyl-1,4-dioxan-2-yl]methyl]azanium;iodide	Investigative	118706052	C9H20INO2	301.17	C[C@@H]1[C@H](OCCO1)C[N+](C)(C)C.[I-]	Ki ~ 100000 nM	Poor binder
T79961	Muscarinic acetylcholine receptor M5	B40WHA	(4R)-4-[(2S)-1-Methylpyrrolidin-2-yl]-1,3-oxazolidin-2-one	Investigative	72545091	C8H14N2O2	170.21	CN1CCC[C@H]1[C@@H]2COC(=O)N2	Ki ~ 100000 nM	Poor binder
T79961	Muscarinic acetylcholine receptor M5	B4BM5X	N-Pentan-3-yl-2-(4-propanoylpiperazin-1-yl)acetamide	Investigative	49853777	C14H27N3O2	269.38	CCC(CC)NC(=O)CN1CCN(CC1)C(=O)CC	IC50 ~ 100000 nM	Poor binder
T79961	Muscarinic acetylcholine receptor M5	B4L6GV	(2R)-1,1-Dimethyl-2-[(2S,4R)-2-methyl-1,3-dioxolan-4-yl]pyrrolidin-1-ium	Investigative	11819782	C10H20NO2+	186.27	C[C@H]1OC[C@H](O1)[C@H]2CCC[N+]2(C)C	Ki = 52480.75 nM	Poor binder
T79961	Muscarinic acetylcholine receptor M5	B4SWH0	6-Chloro-3-[1-[1-[[2-(trifluoromethyl)phenyl]methyl]piperidin-4-yl]piperidin-4-yl]-1H-benzimidazol-2-one	Investigative	44578928	C25H28ClF3N4O	493	C1CN(CCC1N2CCC(CC2)N3C4=C(C=C(C=C4)Cl)NC3=O)CC5=CC=CC=C5C(F)(F)F	EC50 ~ 50000 nM	Poor binder
T79961	Muscarinic acetylcholine receptor M5	B4YCF2	[(2S)-1-(4-Methoxyphenyl)propan-2-yl] 1-ethyl-4-phenyl-3,6-dihydro-2H-pyridine-5-carboxylate	Investigative	71575028	C24H29NO3	379.5	CCN1CCC(=C(C1)C(=O)O[C@@H](C)CC2=CC=C(C=C2)OC)C3=CC=CC=C3	Ki ~ 100000 nM	Poor binder
T79961	Muscarinic acetylcholine receptor M5	B50PAD	3-[1-(1-Benzylpiperidin-4-yl)piperidin-4-yl]-6-chloro-1H-benzimidazol-2-one	Investigative	44579417	C24H29ClN4O	425	C1CN(CCC1N2CCC(CC2)N3C4=C(C=C(C=C4)Cl)NC3=O)CC5=CC=CC=C5	EC50 ~ 50000 nM	Poor binder
T79961	Muscarinic acetylcholine receptor M5	B57EKA	7-Fluoro-3-[1-[1-[(2-methylphenyl)methyl]piperidin-4-yl]piperidin-4-yl]-1H-benzimidazol-2-one	Investigative	44579418	C25H31FN4O	422.5	CC1=CC=CC=C1CN2CCC(CC2)N3CCC(CC3)N4C5=C(C(=CC=C5)F)NC4=O	EC50 ~ 50000 nM	Poor binder
T79961	Muscarinic acetylcholine receptor M5	B57PVF	7-Fluoro-3-[1-[1-[[2-(trifluoromethyl)phenyl]methyl]piperidin-4-yl]piperidin-4-yl]-1H-benzimidazol-2-one	Investigative	44579419	C25H28F4N4O	476.5	C1CN(CCC1N2CCC(CC2)N3C4=C(C(=CC=C4)F)NC3=O)CC5=CC=CC=C5C(F)(F)F	EC50 ~ 50000 nM	Poor binder
T79961	Muscarinic acetylcholine receptor M5	B5BZO0	2-(4-Methoxyphenyl)ethyl 1-[(4-methoxyphenyl)methyl]-4-phenyl-3,6-dihydro-2H-pyridine-5-carboxylate	Investigative	71575336	C29H31NO4	457.6	COC1=CC=C(C=C1)CCOC(=O)C2=C(CCN(C2)CC3=CC=C(C=C3)OC)C4=CC=CC=C4	Ki ~ 100000 nM	Poor binder
T79961	Muscarinic acetylcholine receptor M5	B5ER0C	(5S)-5-[(Dimethylamino)methyl]-3-methyl-1,3-oxazolidin-2-one	Investigative	58653718	C7H14N2O2	158.2	CN1C[C@@H](OC1=O)CN(C)C	Ki ~ 100000 nM	Poor binder
T79961	Muscarinic acetylcholine receptor M5	B5HRN9	Trimethyl-[(6-methyl-1,4-dioxan-2-yl)methyl]azanium;iodide	Investigative	44422691	C9H20INO2	301.17	CC1COCC(O1)C[N+](C)(C)C.[I-]	Ki = 67608.3 nM	Poor binder
T79961	Muscarinic acetylcholine receptor M5	B5J4WP	N,N,N-Trimethyl-alpha-(2-oxooxazolidine-5alpha-yl)methaneaminium	Investigative	73349592	C7H15N2O2+	159.21	C[N+](C)(C)C[C@H]1CNC(=O)O1	Ki ~ 100000 nM	Poor binder
T79961	Muscarinic acetylcholine receptor M5	B5ONL2	Trimethyl-[[(5S)-3-methyl-2-oxo-1,3-oxazolidin-5-yl]methyl]azanium	Investigative	72545329	C8H17N2O2+	173.23	CN1C[C@H](OC1=O)C[N+](C)(C)C	Ki ~ 100000 nM	Poor binder
T79961	Muscarinic acetylcholine receptor M5	B5V6JQ	2-(2,3-Dihydro-1-benzofuran-5-yl)ethyl 1-butyl-4-phenyl-3,6-dihydro-2H-pyridine-5-carboxylate	Investigative	71575449	C26H31NO3	405.5	CCCCN1CCC(=C(C1)C(=O)OCCC2=CC3=C(C=C2)OCC3)C4=CC=CC=C4	Ki ~ 100000 nM	Poor binder
T79961	Muscarinic acetylcholine receptor M5	B68VPY	3-[1-[1-[(2-Chlorophenyl)methyl]piperidin-4-yl]piperidin-4-yl]-1H-benzimidazol-2-one	Investigative	10251795	C24H29ClN4O	425	C1CN(CCC1N2CCC(CC2)N3C4=CC=CC=C4NC3=O)CC5=CC=CC=C5Cl	EC50 ~ 50000 nM	Poor binder
T79961	Muscarinic acetylcholine receptor M5	B6IUM0	3-[1-[1-[(2-Nitrophenyl)methyl]piperidin-4-yl]piperidin-4-yl]-1H-benzimidazol-2-one	Investigative	44578976	C24H29N5O3	435.5	C1CN(CCC1N2CCC(CC2)N3C4=CC=CC=C4NC3=O)CC5=CC=CC=C5[N+](=O)[O-]	EC50 ~ 50000 nM	Poor binder
T79961	Muscarinic acetylcholine receptor M5	B7GRA8	2-(3,4,5-Trimethoxyphenyl)ethyl 1-ethyl-4-phenyl-3,6-dihydro-2H-pyridine-5-carboxylate	Investigative	71575221	C25H31NO5	425.5	CCN1CCC(=C(C1)C(=O)OCCC2=CC(=C(C(=C2)OC)OC)OC)C3=CC=CC=C3	Ki ~ 100000 nM	Poor binder
T79961	Muscarinic acetylcholine receptor M5	B8ACZ5	(5R)-5-[(Dimethylamino)methyl]-3-methyl-1,3-oxazolidin-2-one	Investigative	72545094	C7H14N2O2	158.2	CN1C[C@H](OC1=O)CN(C)C	Ki ~ 100000 nM	Poor binder
T79961	Muscarinic acetylcholine receptor M5	B8CRU7	(5S,2''S)-5-(1-Methyl-2-pyrrolidinyl)oxazolidinone	Investigative	44571572	C8H14N2O2	170.21	CN1CCC[C@H]1[C@@H]2CNC(=O)O2	Ki ~ 100000 nM	Poor binder
T79961	Muscarinic acetylcholine receptor M5	B8FM1A	Trimethyl-[[(2R)-2-methyl-1,4-dioxan-2-yl]methyl]azanium;iodide	Investigative	118706050	C9H20INO2	301.17	C[C@]1(COCCO1)C[N+](C)(C)C.[I-]	Ki ~ 100000 nM	Poor binder
T79961	Muscarinic acetylcholine receptor M5	B8GY1Q	[(2R,5S,6R)-5,6-Dimethyl-1,4-dioxan-2-yl]methyl-trimethylazanium;iodide	Investigative	46227416	C10H22INO2	315.19	C[C@H]1[C@H](O[C@@H](CO1)C[N+](C)(C)C)C.[I-]	Ki ~ 100000 nM	Poor binder
T79961	Muscarinic acetylcholine receptor M5	B8YUV4	N-[2-(Dimethylamino)ethyl]-N-methyl-1-(2-pyridinylmethylene)-1H-indene-3-carboxamide	Investigative	44274417	C21H23N3O	333.4	CN(C)CCN(C)C(=O)C1=C/C(=C\\C2=CC=CC=N2)/C3=CC=CC=C31	Ki = 52480.75 nM	Poor binder
T79961	Muscarinic acetylcholine receptor M5	B95YCK	2-(3,4-Dimethoxyphenyl)ethyl 4-(3-methoxyphenyl)-1-methyl-3,6-dihydro-2H-pyridine-5-carboxylate	Investigative	71574176	C24H29NO5	411.5	CN1CCC(=C(C1)C(=O)OCCC2=CC(=C(C=C2)OC)OC)C3=CC(=CC=C3)OC	Ki ~ 100000 nM	Poor binder
T79961	Muscarinic acetylcholine receptor M5	B9LTS0	Pyrrolidine, 2-(5-methyl-2-furanyl)-, (2S)-	Investigative	7141654	C9H13NO	151.21	CC1=CC=C(O1)[C@@H]2CCCN2	Ki = 138038.43 nM	Poor binder
T79961	Muscarinic acetylcholine receptor M5	B9M3LY	6-Chloro-3-[1-[1-[(2-methylphenyl)methyl]piperidin-4-yl]piperidin-4-yl]-1H-benzimidazol-2-one	Investigative	44579375	C25H31ClN4O	439	CC1=CC=CC=C1CN2CCC(CC2)N3CCC(CC3)N4C5=C(C=C(C=C5)Cl)NC4=O	EC50 ~ 50000 nM	Poor binder
T79961	Muscarinic acetylcholine receptor M5	BB30RM	Esaprazole	Investigative	68835	C12H23N3O	225.33	C1CCC(CC1)NC(=O)CN2CCNCC2	IC50 = 71000 nM	Poor binder
T79961	Muscarinic acetylcholine receptor M5	BB9YX3	N-Isopropyl-1-piperazineacetamide	Investigative	100826	C9H19N3O	185.27	CC(C)NC(=O)CN1CCNCC1	IC50 = 63000 nM	Poor binder
T79961	Muscarinic acetylcholine receptor M5	BC3X5D	N-[2-(Dimethylamino)ethyl]-1-(4-pyridinylmethylene)-1H-indene-3-carboxamide	Investigative	44274433	C20H21N3O	319.4	CN(C)CCNC(=O)C1=C/C(=C\\C2=CC=NC=C2)/C3=CC=CC=C31	Ki = 53703.18 nM	Poor binder
T79961	Muscarinic acetylcholine receptor M5	BC5Y0W	(S)-5beta-[(Dimethylamino)methyl]oxazolidine-2-one	Investigative	73351145	C6H12N2O2	144.17	CN(C)C[C@@H]1CNC(=O)O1	Ki ~ 100000 nM	Poor binder
T79961	Muscarinic acetylcholine receptor M5	BCAJ53	1,1-Diphenyl-4-(4-phenylpiperazin-1-yl)butan-1-ol;hydrochloride	Investigative	49797392	C26H31ClN2O	423	C1CN(CCN1CCCC(C2=CC=CC=C2)(C3=CC=CC=C3)O)C4=CC=CC=C4.Cl	Ki = 123026.88 nM	Poor binder
T79961	Muscarinic acetylcholine receptor M5	BCJ98E	Trimethyl-[[(2R,5R)-5-methyl-1,4-dioxan-2-yl]methyl]azanium;iodide	Investigative	46227554	C9H20INO2	301.17	C[C@@H]1CO[C@@H](CO1)C[N+](C)(C)C.[I-]	Ki = 93325.43 nM	Poor binder
T79961	Muscarinic acetylcholine receptor M5	BDA42Y	2,3-Dihydro-1-benzofuran-5-ylmethyl 1-methyl-4-phenyl-3,6-dihydro-2H-pyridine-5-carboxylate	Investigative	71575451	C22H23NO3	349.4	CN1CCC(=C(C1)C(=O)OCC2=CC3=C(C=C2)OCC3)C4=CC=CC=C4	Ki ~ 100000 nM	Poor binder
T79961	Muscarinic acetylcholine receptor M5	BDPT63	[(2S)-1-Methylpyrrolidin-2-yl]methyl carbamate	Investigative	72545089	C7H14N2O2	158.2	CN1CCC[C@H]1COC(=O)N	Ki ~ 100000 nM	Poor binder
T79961	Muscarinic acetylcholine receptor M5	BE2OY8	5-Fluoro-3-[1-[1-[[2-(trifluoromethyl)phenyl]methyl]piperidin-4-yl]piperidin-4-yl]-1H-benzimidazol-2-one	Investigative	44579458	C25H28F4N4O	476.5	C1CN(CCC1N2CCC(CC2)N3C4=C(C=CC(=C4)F)NC3=O)CC5=CC=CC=C5C(F)(F)F	EC50 ~ 50000 nM	Poor binder
T79961	Muscarinic acetylcholine receptor M5	BF67LJ	N-[2-(Dimethylamino)ethyl]-3-(pyridin-3-ylmethyl)-1H-indene-2-carboxamide	Investigative	11759058	C20H23N3O	321.4	CN(C)CCNC(=O)C1=C(C2=CC=CC=C2C1)CC3=CN=CC=C3	Ki = 66069.34 nM	Poor binder
T79961	Muscarinic acetylcholine receptor M5	BG3P0I	2-[[4-[4-(5-Chloro-2-oxo-3H-benzimidazol-1-yl)piperidin-1-yl]piperidin-1-yl]methyl]benzonitrile	Investigative	44579416	C25H28ClN5O	450	C1CN(CCC1N2CCC(CC2)N3C4=C(C=C(C=C4)Cl)NC3=O)CC5=CC=CC=C5C#N	EC50 ~ 50000 nM	Poor binder
T79961	Muscarinic acetylcholine receptor M5	BG5E7Y	1,4-Dimethyl-3-(4-methylthio-1,2,5-thiadiazol-3-yl)-1,2,5,6-tetrahydropyridine	Investigative	10354348	C10H15N3S2	241.4	CC1=C(CN(CC1)C)C2=NSN=C2SC	IC50 = 100000 nM	Poor binder
T79961	Muscarinic acetylcholine receptor M5	BGAU76	2-(3,4-Dimethoxyphenyl)ethyl 4-(2-fluorophenyl)-1-methyl-3,6-dihydro-2H-pyridine-5-carboxylate	Investigative	71574175	C23H26FNO4	399.5	CN1CCC(=C(C1)C(=O)OCCC2=CC(=C(C=C2)OC)OC)C3=CC=CC=C3F	Ki ~ 100000 nM	Poor binder
T79961	Muscarinic acetylcholine receptor M5	BGH14T	Ethyl 1-[2-(2,3-dihydro-1-benzofuran-5-yl)ethyl]-4-phenyl-3,6-dihydro-2H-pyridine-5-carboxylate	Investigative	71574180	C24H27NO3	377.5	CCOC(=O)C1=C(CCN(C1)CCC2=CC3=C(C=C2)OCC3)C4=CC=CC=C4	Ki ~ 100000 nM	Poor binder
T79961	Muscarinic acetylcholine receptor M5	BGM1F0	2-[(8Ar)-3,4,6,7,8,8a-hexahydro-1H-pyrrolo[1,2-a]pyrazin-2-yl]-N-cyclohexylacetamide	Investigative	49853883	C15H27N3O	265.39	C1CCC(CC1)NC(=O)CN2CCN3CCC[C@@H]3C2	IC50 = 74000 nM	Poor binder
T79961	Muscarinic acetylcholine receptor M5	BHS92K	(2S,3R,5S)-5-[(2S)-1,1-Dimethylpyrrolidin-1-ium-2-yl]-2-methyl-1,3-oxathiolane 3-oxide;iodide	Investigative	11530306	C10H20INO2S	345.24	C[C@H]1O[C@H](C[S@]1=O)[C@@H]2CCC[N+]2(C)C.[I-]	Ki = 57543.99 nM	Poor binder
T79961	Muscarinic acetylcholine receptor M5	BI6DN8	5-Fluoro-3-[1-[1-[(2-methylphenyl)methyl]piperidin-4-yl]piperidin-4-yl]-1H-benzimidazol-2-one	Investigative	25110765	C25H31FN4O	422.5	CC1=CC=CC=C1CN2CCC(CC2)N3CCC(CC3)N4C5=C(C=CC(=C5)F)NC4=O	EC50 ~ 50000 nM	Poor binder
T79961	Muscarinic acetylcholine receptor M5	BI85JF	[(2R,6R)-6-Ethyl-1,4-dioxan-2-yl]methyl-trimethylazanium;iodide	Investigative	57326141	C10H22INO2	315.19	CC[C@@H]1COC[C@H](O1)C[N+](C)(C)C.[I-]	Ki ~ 100000 nM	Poor binder
T79961	Muscarinic acetylcholine receptor M5	BID3M1	2-(2,3-Dihydro-1-benzofuran-5-yl)ethyl 4-(3-fluorophenyl)-1-methyl-3,6-dihydro-2H-pyridine-5-carboxylate	Investigative	71575651	C23H24FNO3	381.4	CN1CCC(=C(C1)C(=O)OCCC2=CC3=C(C=C2)OCC3)C4=CC(=CC=C4)F	Ki ~ 100000 nM	Poor binder
T79961	Muscarinic acetylcholine receptor M5	BIO5L9	N-Cyclohexyl-2-(4-cyclopentylpiperazin-1-yl)-2-methylpropanamide	Investigative	49853987	C19H35N3O	321.5	CC(C)(C(=O)NC1CCCCC1)N2CCN(CC2)C3CCCC3	IC50 ~ 100000 nM	Poor binder
T79961	Muscarinic acetylcholine receptor M5	BJDS46	2-(2,4,6-Trimethylphenyl)ethyl 1-ethyl-4-phenyl-3,6-dihydro-2H-pyridine-5-carboxylate	Investigative	71575222	C25H31NO2	377.5	CCN1CCC(=C(C1)C(=O)OCCC2=C(C=C(C=C2C)C)C)C3=CC=CC=C3	Ki ~ 100000 nM	Poor binder
T79961	Muscarinic acetylcholine receptor M5	BJEV61	Trimethyl-[[(2R)-5,5,6,6-tetramethyl-1,4-dioxan-2-yl]methyl]azanium;iodide	Investigative	46227486	C12H26INO2	343.24	CC1(C(O[C@@H](CO1)C[N+](C)(C)C)(C)C)C.[I-]	Ki = 66069.34 nM	Poor binder
T79961	Muscarinic acetylcholine receptor M5	BK4Q9G	2-(3,4-Dimethoxyphenyl)ethyl 4-(2-methoxyphenyl)-1-methyl-3,6-dihydro-2H-pyridine-5-carboxylate	Investigative	71574177	C24H29NO5	411.5	CN1CCC(=C(C1)C(=O)OCCC2=CC(=C(C=C2)OC)OC)C3=CC=CC=C3OC	Ki ~ 100000 nM	Poor binder
T79961	Muscarinic acetylcholine receptor M5	BKR16E	Trimethyl-[[(2R,6R)-6-methyl-1,4-dioxan-2-yl]methyl]azanium;iodide	Investigative	44446840	C9H20INO2	301.17	C[C@@H]1COC[C@H](O1)C[N+](C)(C)C.[I-]	Ki = 67608.3 nM	Poor binder
T79961	Muscarinic acetylcholine receptor M5	BL86PX	[(2R,5R,6S)-5,6-Dimethyl-1,4-dioxan-2-yl]methyl-trimethylazanium;iodide	Investigative	46227454	C10H22INO2	315.19	C[C@@H]1[C@@H](O[C@@H](CO1)C[N+](C)(C)C)C.[I-]	Ki = 97723.72 nM	Poor binder
T79961	Muscarinic acetylcholine receptor M5	BM5FV4	2-(4-Cyclohexylpiperazin-1-yl)-2-methyl-N-propan-2-ylpropanamide	Investigative	49853885	C17H33N3O	295.5	CC(C)NC(=O)C(C)(C)N1CCN(CC1)C2CCCCC2	IC50 ~ 100000 nM	Poor binder
T79961	Muscarinic acetylcholine receptor M5	BMVB24	Ethyl 1-[1-(2,6-dimethylbenzoyl)piperidin-4-yl]-4-phenyl-3,6-dihydro-2H-pyridine-5-carboxylate	Investigative	71574269	C28H34N2O3	446.6	CCOC(=O)C1=C(CCN(C1)C2CCN(CC2)C(=O)C3=C(C=CC=C3C)C)C4=CC=CC=C4	Ki ~ 100000 nM	Poor binder
T79961	Muscarinic acetylcholine receptor M5	BNL89F	Trimethyl-[[(2R,6R)-5,5,6-trimethyl-1,4-dioxan-2-yl]methyl]azanium;iodide	Investigative	46227480	C11H24INO2	329.22	C[C@@H]1C(OC[C@H](O1)C[N+](C)(C)C)(C)C.[I-]	Ki = 83176.38 nM	Poor binder
T79961	Muscarinic acetylcholine receptor M5	BNT2J0	Ethyl 1-[2-(1,3-benzodioxol-5-yl)ethyl]-4-phenyl-3,6-dihydro-2H-pyridine-5-carboxylate	Investigative	71574268	C23H25NO4	379.4	CCOC(=O)C1=C(CCN(C1)CCC2=CC3=C(C=C2)OCO3)C4=CC=CC=C4	Ki ~ 100000 nM	Poor binder
T79961	Muscarinic acetylcholine receptor M5	BO3YC0	6-Chloro-3-[1-[1-[(2-chlorophenyl)methyl]piperidin-4-yl]piperidin-4-yl]-1H-benzimidazol-2-one	Investigative	44578975	C24H28Cl2N4O	459.4	C1CN(CCC1N2CCC(CC2)N3C4=C(C=C(C=C4)Cl)NC3=O)CC5=CC=CC=C5Cl	EC50 ~ 50000 nM	Poor binder
T79961	Muscarinic acetylcholine receptor M5	BO61QD	Trimethyl-[[(2R,5S)-5-methyl-1,4-dioxan-2-yl]methyl]azanium;iodide	Investigative	46227410	C9H20INO2	301.17	C[C@H]1CO[C@@H](CO1)C[N+](C)(C)C.[I-]	Ki = 63095.73 nM	Poor binder
T79961	Muscarinic acetylcholine receptor M5	BPJR69	Ethyl 1-[1-(4-methylphenyl)sulfonylpiperidin-4-yl]-4-phenyl-3,6-dihydro-2H-pyridine-5-carboxylate	Investigative	71574271	C26H32N2O4S	468.6	CCOC(=O)C1=C(CCN(C1)C2CCN(CC2)S(=O)(=O)C3=CC=C(C=C3)C)C4=CC=CC=C4	Ki ~ 100000 nM	Poor binder
T79961	Muscarinic acetylcholine receptor M5	BS1D3A	2-(4-Methoxyphenyl)ethyl 1-butyl-4-phenyl-3,6-dihydro-2H-pyridine-5-carboxylate	Investigative	71575339	C25H31NO3	393.5	CCCCN1CCC(=C(C1)C(=O)OCCC2=CC=C(C=C2)OC)C3=CC=CC=C3	Ki ~ 100000 nM	Poor binder
T79961	Muscarinic acetylcholine receptor M5	BS9AF4	Trimethyl-[[(2R,6S)-5,5,6-trimethyl-1,4-dioxan-2-yl]methyl]azanium;iodide	Investigative	46227460	C11H24INO2	329.22	C[C@H]1C(OC[C@H](O1)C[N+](C)(C)C)(C)C.[I-]	Ki = 52480.75 nM	Poor binder
T79961	Muscarinic acetylcholine receptor M5	BSZ0N4	2-(2,3-Dihydro-1-benzofuran-5-yl)ethyl 2-(1-methyl-3,6-dihydro-2H-pyridin-4-yl)benzoate	Investigative	71574367	C23H25NO3	363.4	CN1CCC(=CC1)C2=CC=CC=C2C(=O)OCCC3=CC4=C(C=C3)OCC4	Ki ~ 100000 nM	Poor binder
T79961	Muscarinic acetylcholine receptor M5	BT17YZ	2-(2,3-Dihydro-1-benzofuran-5-yl)ethyl 4-phenyl-1-propyl-3,6-dihydro-2H-pyridine-5-carboxylate	Investigative	71575448	C25H29NO3	391.5	CCCN1CCC(=C(C1)C(=O)OCCC2=CC3=C(C=C2)OCC3)C4=CC=CC=C4	Ki ~ 100000 nM	Poor binder
T79961	Muscarinic acetylcholine receptor M5	BT83FB	(2-Methoxy-2-phenylethyl) 1-methyl-4-phenyl-3,6-dihydro-2H-pyridine-5-carboxylate	Investigative	71575554	C22H25NO3	351.4	CN1CCC(=C(C1)C(=O)OCC(C2=CC=CC=C2)OC)C3=CC=CC=C3	Ki ~ 100000 nM	Poor binder
T79961	Muscarinic acetylcholine receptor M5	BTF8M9	(5R,2''S)-5-(1-Methyl-2-pyrrolidinyl)oxazolidinone	Investigative	44419370	C8H14N2O2	170.21	CN1CCC[C@H]1[C@H]2CNC(=O)O2	Ki ~ 100000 nM	Poor binder
T79961	Muscarinic acetylcholine receptor M5	BTH09U	Trimethyl-[[(2R,3S)-3-methyl-1,4-dioxan-2-yl]methyl]azanium;iodide	Investigative	118723724	C9H20INO2	301.17	C[C@H]1[C@H](OCCO1)C[N+](C)(C)C.[I-]	Ki ~ 100000 nM	Poor binder
T79961	Muscarinic acetylcholine receptor M5	BTHE57	Trimethyl-[[(5R)-3-methyl-2-oxo-1,3-oxazolidin-5-yl]methyl]azanium	Investigative	72545096	C8H17N2O2+	173.23	CN1C[C@@H](OC1=O)C[N+](C)(C)C	Ki ~ 100000 nM	Poor binder
T79961	Muscarinic acetylcholine receptor M5	BTZ9Y2	6-Fluoro-3-[1-[1-[(2-methylphenyl)methyl]piperidin-4-yl]piperidin-4-yl]-1H-benzimidazol-2-one	Investigative	25110764	C25H31FN4O	422.5	CC1=CC=CC=C1CN2CCC(CC2)N3CCC(CC3)N4C5=C(C=C(C=C5)F)NC4=O	EC50 ~ 50000 nM	Poor binder
T79961	Muscarinic acetylcholine receptor M5	BU4GJ8	N-[2-(Dimethylamino)ethyl]-1-(2-pyridinylmethylene)-1H-indene-3-carboxamide	Investigative	44274317	C20H21N3O	319.4	CN(C)CCNC(=O)C1=C/C(=C\\C2=CC=CC=N2)/C3=CC=CC=C31	Ki = 54954.09 nM	Poor binder
T79961	Muscarinic acetylcholine receptor M5	BU4J8L	Tbpb	Investigative	10092649	C25H32N4O	404.5	CC1=CC=CC=C1CN2CCC(CC2)N3CCC(CC3)N4C5=CC=CC=C5NC4=O	EC50 ~ 50000 nM	Poor binder
T79961	Muscarinic acetylcholine receptor M5	BUQ86I	N-[2-(Dimethylamino)ethyl]-1-(3-pyridinylmethylene)-1H-indene-3-carboxamide	Investigative	44274400	C20H21N3O	319.4	CN(C)CCNC(=O)C1=C/C(=C\\C2=CN=CC=C2)/C3=CC=CC=C31	Ki = 66069.34 nM	Poor binder
T79961	Muscarinic acetylcholine receptor M5	BV0B7Z	Ethyl 4-phenyl-1-(2-phenylethyl)-3,6-dihydro-2H-pyridine-5-carboxylate	Investigative	71574178	C22H25NO2	335.4	CCOC(=O)C1=C(CCN(C1)CCC2=CC=CC=C2)C3=CC=CC=C3	Ki ~ 100000 nM	Poor binder
T79961	Muscarinic acetylcholine receptor M5	BW3N6H	2-(4-Methoxyphenyl)ethyl 4-phenyl-1-propyl-3,6-dihydro-2H-pyridine-5-carboxylate	Investigative	71575338	C24H29NO3	379.5	CCCN1CCC(=C(C1)C(=O)OCCC2=CC=C(C=C2)OC)C3=CC=CC=C3	Ki ~ 100000 nM	Poor binder
T79961	Muscarinic acetylcholine receptor M5	BWB3G2	(4-Methylpiperazin-1-yl)-[(3E)-3-(pyridin-4-ylmethylidene)inden-1-yl]methanone	Investigative	44274477	C21H21N3O	331.4	CN1CCN(CC1)C(=O)C2=C/C(=C\\C3=CC=NC=C3)/C4=CC=CC=C42	Ki = 54954.09 nM	Poor binder
T79961	Muscarinic acetylcholine receptor M5	BWBH45	[(2S)-1,1-Dimethylpyrrolidin-1-ium-2-yl]methyl carbamate	Investigative	72545098	C8H17N2O2+	173.23	C[N+]1(CCC[C@H]1COC(=O)N)C	Ki ~ 100000 nM	Poor binder
T79961	Muscarinic acetylcholine receptor M5	BWF9Y6	[(2R)-5,5-Dimethyl-1,4-dioxan-2-yl]methyl-trimethylazanium;iodide	Investigative	46227458	C10H22INO2	315.19	CC1(CO[C@@H](CO1)C[N+](C)(C)C)C.[I-]	Ki ~ 100000 nM	Poor binder
T79961	Muscarinic acetylcholine receptor M5	BYC1I9	3-[1-[1-[[2-(Trifluoromethyl)phenyl]methyl]piperidin-4-yl]piperidin-4-yl]-1H-benzimidazol-2-one	Investigative	10027177	C25H29F3N4O	458.5	C1CN(CCC1N2CCC(CC2)N3C4=CC=CC=C4NC3=O)CC5=CC=CC=C5C(F)(F)F	EC50 ~ 50000 nM	Poor binder
T79961	Muscarinic acetylcholine receptor M5	BYF2O7	(2R,5R)-5-[(2S)-1,1-Dimethylpyrrolidin-1-ium-2-yl]-2-methyl-1,3-oxathiolane 3-oxide	Investigative	45266386	C10H20NO2S+	218.34	C[C@@H]1O[C@@H](CS1=O)[C@@H]2CCC[N+]2(C)C	Ki = 57543.99 nM	Poor binder
T79961	Muscarinic acetylcholine receptor M5	BYJ7E6	2-(4-Methylsulfonylphenyl)ethyl 1-ethyl-4-phenyl-3,6-dihydro-2H-pyridine-5-carboxylate	Investigative	71575121	C23H27NO4S	413.5	CCN1CCC(=C(C1)C(=O)OCCC2=CC=C(C=C2)S(=O)(=O)C)C3=CC=CC=C3	Ki ~ 100000 nM	Poor binder
T79961	Muscarinic acetylcholine receptor M5	BYTO08	N-Cyclohexyl-2-(4-cyclopentylpiperazin-1-yl)acetamide	Investigative	49853881	C17H31N3O	293.4	C1CCC(CC1)NC(=O)CN2CCN(CC2)C3CCCC3	IC50 ~ 100000 nM	Poor binder
T79961	Muscarinic acetylcholine receptor M5	BYX70W	N-Cyclohexyl-2-(4-methyl-1,4-diazepan-1-yl)acetamide	Investigative	49855131	C14H27N3O	253.38	CN1CCCN(CC1)CC(=O)NC2CCCCC2	IC50 ~ 100000 nM	Poor binder
T79961	Muscarinic acetylcholine receptor M5	BYXU78	(R)-5alpha-[(Dimethylamino)methyl]oxazolidine-2-one	Investigative	57558000	C6H12N2O2	144.17	CN(C)C[C@H]1CNC(=O)O1	Ki ~ 100000 nM	Poor binder
T79961	Muscarinic acetylcholine receptor M5	BZ27OF	Ethyl 1-[1-(2,6-dichlorobenzoyl)piperidin-4-yl]-4-phenyl-3,6-dihydro-2H-pyridine-5-carboxylate	Investigative	71717914	C26H28Cl2N2O3	487.4	CCOC(=O)C1=C(CCN(C1)C2CCN(CC2)C(=O)C3=C(C=CC=C3Cl)Cl)C4=CC=CC=C4	Ki ~ 100000 nM	Poor binder
T79961	Muscarinic acetylcholine receptor M5	BZ3UC8	6-Chloro-3-[1-[1-[(2-nitrophenyl)methyl]piperidin-4-yl]piperidin-4-yl]-1H-benzimidazol-2-one	Investigative	44578977	C24H28ClN5O3	470	C1CN(CCC1N2CCC(CC2)N3C4=C(C=C(C=C4)Cl)NC3=O)CC5=CC=CC=C5[N+](=O)[O-]	EC50 ~ 50000 nM	Poor binder
T79961	Muscarinic acetylcholine receptor M5	BZ4I0N	(4S)-4-[(2S)-1-Methylpyrrolidin-2-yl]-1,3-oxazolidin-2-one	Investigative	72545326	C8H14N2O2	170.21	CN1CCC[C@H]1[C@H]2COC(=O)N2	Ki ~ 100000 nM	Poor binder
T79961	Muscarinic acetylcholine receptor M5	BZP0V3	[(2R,5R,6R)-5,6-Dimethyl-1,4-dioxan-2-yl]methyl-trimethylazanium;iodide	Investigative	46227414	C10H22INO2	315.19	C[C@@H]1[C@H](O[C@@H](CO1)C[N+](C)(C)C)C.[I-]	Ki ~ 100000 nM	Poor binder